Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 7.48563104 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.48563104 |
3 | L-phenylalanine metabolic process (GO:0006558) | 7.21195224 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.21195224 |
5 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.73451576 |
6 | aromatic amino acid family catabolic process (GO:0009074) | 6.65493562 |
7 | intestinal cholesterol absorption (GO:0030299) | 6.19126601 |
8 | negative regulation of fibrinolysis (GO:0051918) | 6.10718991 |
9 | glyoxylate metabolic process (GO:0046487) | 6.04505861 |
10 | tryptophan catabolic process (GO:0006569) | 5.93102012 |
11 | indole-containing compound catabolic process (GO:0042436) | 5.93102012 |
12 | indolalkylamine catabolic process (GO:0046218) | 5.93102012 |
13 | kynurenine metabolic process (GO:0070189) | 5.85881498 |
14 | regulation of fibrinolysis (GO:0051917) | 5.83834399 |
15 | bile acid biosynthetic process (GO:0006699) | 5.75294755 |
16 | urea cycle (GO:0000050) | 5.63777092 |
17 | urea metabolic process (GO:0019627) | 5.63777092 |
18 | * high-density lipoprotein particle remodeling (GO:0034375) | 5.61058097 |
19 | tryptophan metabolic process (GO:0006568) | 5.60955765 |
20 | protein carboxylation (GO:0018214) | 5.46889255 |
21 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.46889255 |
22 | sulfur amino acid catabolic process (GO:0000098) | 5.43228268 |
23 | cysteine metabolic process (GO:0006534) | 5.37637191 |
24 | * protein-lipid complex subunit organization (GO:0071825) | 5.37616689 |
25 | regulation of protein activation cascade (GO:2000257) | 5.36348571 |
26 | regulation of cholesterol esterification (GO:0010872) | 5.33668661 |
27 | alpha-linolenic acid metabolic process (GO:0036109) | 5.27592991 |
28 | complement activation, alternative pathway (GO:0006957) | 5.21181585 |
29 | serine family amino acid catabolic process (GO:0009071) | 5.19504721 |
30 | nitrogen cycle metabolic process (GO:0071941) | 5.17937451 |
31 | regulation of apoptotic cell clearance (GO:2000425) | 5.11999925 |
32 | regulation of triglyceride catabolic process (GO:0010896) | 5.06166705 |
33 | * reverse cholesterol transport (GO:0043691) | 5.01815074 |
34 | phospholipid efflux (GO:0033700) | 4.99203615 |
35 | regulation of complement activation (GO:0030449) | 4.96301785 |
36 | bile acid metabolic process (GO:0008206) | 4.90998989 |
37 | * protein-lipid complex remodeling (GO:0034368) | 4.89754202 |
38 | * macromolecular complex remodeling (GO:0034367) | 4.89754202 |
39 | * plasma lipoprotein particle remodeling (GO:0034369) | 4.89754202 |
40 | aromatic amino acid family metabolic process (GO:0009072) | 4.86508655 |
41 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.80005017 |
42 | acylglycerol homeostasis (GO:0055090) | 4.77710768 |
43 | triglyceride homeostasis (GO:0070328) | 4.77710768 |
44 | tyrosine metabolic process (GO:0006570) | 4.74252484 |
45 | homocysteine metabolic process (GO:0050667) | 4.74243614 |
46 | proline metabolic process (GO:0006560) | 4.69827618 |
47 | negative regulation of sterol transport (GO:0032372) | 4.67904014 |
48 | negative regulation of cholesterol transport (GO:0032375) | 4.67904014 |
49 | lysine metabolic process (GO:0006553) | 4.63803673 |
50 | lysine catabolic process (GO:0006554) | 4.63803673 |
51 | amino-acid betaine metabolic process (GO:0006577) | 4.61820863 |
52 | alpha-amino acid catabolic process (GO:1901606) | 4.60060755 |
53 | cellular ketone body metabolic process (GO:0046950) | 4.52825063 |
54 | glycine metabolic process (GO:0006544) | 4.49314246 |
55 | * plasma lipoprotein particle clearance (GO:0034381) | 4.46482297 |
56 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 4.42819875 |
57 | epoxygenase P450 pathway (GO:0019373) | 4.41087378 |
58 | negative regulation of hemostasis (GO:1900047) | 4.38806441 |
59 | negative regulation of blood coagulation (GO:0030195) | 4.38806441 |
60 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 4.38415133 |
61 | positive regulation of hemostasis (GO:1900048) | 4.37937029 |
62 | positive regulation of blood coagulation (GO:0030194) | 4.37937029 |
63 | regulation of humoral immune response (GO:0002920) | 4.29287538 |
64 | serine family amino acid metabolic process (GO:0009069) | 4.27515895 |
65 | cellular amino acid catabolic process (GO:0009063) | 4.25608318 |
66 | fibrinolysis (GO:0042730) | 4.25468986 |
67 | * cholesterol efflux (GO:0033344) | 4.25185293 |
68 | glutamate metabolic process (GO:0006536) | 4.23860878 |
69 | indolalkylamine metabolic process (GO:0006586) | 4.20723226 |
70 | imidazole-containing compound metabolic process (GO:0052803) | 4.19863058 |
71 | serine family amino acid biosynthetic process (GO:0009070) | 4.19201146 |
72 | blood coagulation, intrinsic pathway (GO:0007597) | 4.16378717 |
73 | bile acid and bile salt transport (GO:0015721) | 4.15707594 |
74 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.13354529 |
75 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.13354529 |
76 | low-density lipoprotein particle remodeling (GO:0034374) | 4.12943568 |
77 | cellular modified amino acid catabolic process (GO:0042219) | 4.12237027 |
78 | coenzyme catabolic process (GO:0009109) | 4.12015438 |
79 | cellular biogenic amine catabolic process (GO:0042402) | 4.11578150 |
80 | amine catabolic process (GO:0009310) | 4.11578150 |
81 | arginine metabolic process (GO:0006525) | 4.09529731 |
82 | aldehyde catabolic process (GO:0046185) | 4.08354584 |
83 | benzene-containing compound metabolic process (GO:0042537) | 4.03203950 |
84 | negative regulation of coagulation (GO:0050819) | 4.02566632 |
85 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.01052222 |
86 | * plasma lipoprotein particle assembly (GO:0034377) | 3.98959260 |
87 | positive regulation of coagulation (GO:0050820) | 3.98435801 |
88 | intestinal absorption (GO:0050892) | 3.97536790 |
89 | diacylglycerol metabolic process (GO:0046339) | 3.97529838 |
90 | drug catabolic process (GO:0042737) | 3.95795575 |
91 | * cholesterol transport (GO:0030301) | 3.95438450 |
92 | * sterol transport (GO:0015918) | 3.95438450 |
93 | cellular glucuronidation (GO:0052695) | 3.95006918 |
94 | phospholipid homeostasis (GO:0055091) | 3.92014526 |
95 | ketone body metabolic process (GO:1902224) | 3.91779112 |
96 | negative regulation of lipase activity (GO:0060192) | 3.87765446 |
97 | positive regulation of lipid catabolic process (GO:0050996) | 3.87294259 |
98 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.85131985 |
99 | ethanol oxidation (GO:0006069) | 3.82438948 |
100 | negative regulation of wound healing (GO:0061045) | 3.80137876 |
101 | regulation of plasminogen activation (GO:0010755) | 3.79956285 |
102 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.79139419 |
103 | cofactor catabolic process (GO:0051187) | 3.78916993 |
104 | * cholesterol homeostasis (GO:0042632) | 3.78248156 |
105 | ethanol metabolic process (GO:0006067) | 3.77355485 |
106 | regulation of cholesterol homeostasis (GO:2000188) | 3.76285397 |
107 | positive regulation of steroid metabolic process (GO:0045940) | 3.75724548 |
108 | protein activation cascade (GO:0072376) | 3.75620079 |
109 | * plasma lipoprotein particle organization (GO:0071827) | 3.73124422 |
110 | organic acid catabolic process (GO:0016054) | 3.72013912 |
111 | carboxylic acid catabolic process (GO:0046395) | 3.72013912 |
112 | * sterol homeostasis (GO:0055092) | 3.71989225 |
113 | omega-hydroxylase P450 pathway (GO:0097267) | 3.71309295 |
114 | exogenous drug catabolic process (GO:0042738) | 3.71299252 |
115 | heme transport (GO:0015886) | 3.69949578 |
116 | negative regulation of complement activation (GO:0045916) | 3.69711397 |
117 | acute-phase response (GO:0006953) | 3.66981087 |
118 | regulation of cholesterol biosynthetic process (GO:0045540) | 3.65849529 |
119 | short-chain fatty acid metabolic process (GO:0046459) | 3.64908415 |
120 | complement activation, classical pathway (GO:0006958) | 3.64080915 |
121 | negative regulation of protein activation cascade (GO:2000258) | 3.63880684 |
122 | complement activation (GO:0006956) | 3.62965870 |
123 | cytolysis (GO:0019835) | 3.58766433 |
124 | peptidyl-glutamic acid modification (GO:0018200) | 3.57674842 |
125 | * protein-lipid complex assembly (GO:0065005) | 3.55511209 |
126 | NAD biosynthetic process (GO:0009435) | 3.54377011 |
127 | * lipoprotein metabolic process (GO:0042157) | 3.54127915 |
128 | regulation of bile acid biosynthetic process (GO:0070857) | 3.53665243 |
129 | acetyl-CoA metabolic process (GO:0006084) | 3.52904889 |
130 | proline biosynthetic process (GO:0006561) | 3.40635395 |
131 | acute inflammatory response (GO:0002526) | 3.40180030 |
132 | acylglycerol catabolic process (GO:0046464) | 3.36791942 |
133 | neutral lipid catabolic process (GO:0046461) | 3.36791942 |
134 | positive regulation of extracellular matrix organization (GO:1903055) | 3.36556830 |
135 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.32227588 |
136 | * lipid homeostasis (GO:0055088) | 3.29001676 |
137 | regulation of lipoprotein particle clearance (GO:0010984) | 3.28250167 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.39507685 |
2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.21720457 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.97504057 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.47039238 |
5 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.28781148 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.23050190 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.98198855 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 4.10868952 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.92579557 |
10 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.60425451 |
11 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.24075991 |
12 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.13733684 |
13 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.05912708 |
14 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 12.2195779 |
15 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.98134144 |
16 | GATA1_22025678_ChIP-Seq_K562_Human | 1.64354982 |
17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.60051195 |
18 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.59993766 |
19 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.47863527 |
20 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.43205797 |
21 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.42581389 |
22 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.37588305 |
23 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.31469325 |
24 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.26810948 |
25 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.23144667 |
26 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22825878 |
27 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.19555518 |
28 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.16385870 |
29 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.09732353 |
30 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.01676483 |
31 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.00446214 |
32 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.99982191 |
33 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.93777414 |
34 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.91761033 |
35 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.90567491 |
36 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.90387951 |
37 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.86503227 |
38 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.85801928 |
39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.84118291 |
40 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.83355130 |
41 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.82445154 |
42 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82165631 |
43 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.81532040 |
44 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.79739157 |
45 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.79430411 |
46 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.78157586 |
47 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.77406493 |
48 | * POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.75217525 |
49 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.74796053 |
50 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.74339112 |
51 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.73205716 |
52 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.71634136 |
53 | * RAC3_21632823_ChIP-Seq_H3396_Human | 0.71396744 |
54 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.70956000 |
55 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.70754367 |
56 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.68453932 |
57 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.67444572 |
58 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.66533928 |
59 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.66394742 |
60 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.65983936 |
61 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.65975714 |
62 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.65944739 |
63 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.65557393 |
64 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.65202094 |
65 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.65183117 |
66 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.65050569 |
67 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.63593708 |
68 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.61295977 |
69 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.61132638 |
70 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.61060309 |
71 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.60516957 |
72 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.60246008 |
73 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.60017780 |
74 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.59574051 |
75 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.59226070 |
76 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.58776453 |
77 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.58027702 |
78 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.57899834 |
79 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.57796184 |
80 | GATA1_19941826_ChIP-Seq_K562_Human | 0.57126321 |
81 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.56899131 |
82 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.56775341 |
83 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.55937868 |
84 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.55286641 |
85 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.55104188 |
86 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.55056294 |
87 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.54436502 |
88 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.53933942 |
89 | AR_20517297_ChIP-Seq_VCAP_Human | 0.53811999 |
90 | P68_20966046_ChIP-Seq_HELA_Human | 0.53558999 |
91 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.53338358 |
92 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.50907536 |
93 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.50907536 |
94 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.50777894 |
95 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.50129603 |
96 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.50046131 |
97 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.49862110 |
98 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.48939870 |
99 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.48853187 |
100 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.48384186 |
101 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.48228133 |
102 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.48124568 |
103 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.48042806 |
104 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.47981657 |
105 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.47776721 |
106 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.47520286 |
107 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.47280643 |
108 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.47246771 |
109 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.46597893 |
110 | GATA2_19941826_ChIP-Seq_K562_Human | 0.45875867 |
111 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.44857714 |
112 | CBP_21632823_ChIP-Seq_H3396_Human | 0.44528182 |
113 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.43658715 |
114 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 0.43528891 |
115 | * P53_21459846_ChIP-Seq_SAOS-2_Human | 0.43459069 |
116 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.42789447 |
117 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.42507866 |
118 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.42161685 |
119 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.40189666 |
120 | * PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.40048828 |
121 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.40023035 |
122 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.39414918 |
123 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.38743877 |
124 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.38648940 |
125 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.38164552 |
126 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.38033584 |
127 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.37622445 |
128 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.37378677 |
129 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.37236454 |
130 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.37076106 |
131 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.36878774 |
132 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.36606042 |
133 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.35839605 |
134 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.35411117 |
135 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.35363819 |
136 | SOX3_22085726_ChIP-Seq_MUSCLE_Mouse | 0.34666827 |
137 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.34316720 |
138 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.34296668 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 8.12964286 |
2 | MP0005360_urolithiasis | 7.65040418 |
3 | MP0005085_abnormal_gallbladder_physiolo | 6.28412110 |
4 | MP0005365_abnormal_bile_salt | 6.12105492 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.95663744 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.15031390 |
7 | MP0003252_abnormal_bile_duct | 3.76508869 |
8 | * MP0010329_abnormal_lipoprotein_level | 3.54016643 |
9 | MP0009840_abnormal_foam_cell | 3.53858789 |
10 | MP0003122_maternal_imprinting | 3.45455388 |
11 | MP0005083_abnormal_biliary_tract | 3.06657928 |
12 | MP0005332_abnormal_amino_acid | 2.87088383 |
13 | MP0003195_calcinosis | 2.84428119 |
14 | MP0003191_abnormal_cellular_cholesterol | 2.70716462 |
15 | MP0001666_abnormal_nutrient_absorption | 2.56829580 |
16 | MP0004019_abnormal_vitamin_homeostasis | 2.34615453 |
17 | MP0000609_abnormal_liver_physiology | 2.18455243 |
18 | * MP0002118_abnormal_lipid_homeostasis | 2.05878836 |
19 | MP0002138_abnormal_hepatobiliary_system | 2.04177419 |
20 | MP0003868_abnormal_feces_composition | 1.84679282 |
21 | MP0005319_abnormal_enzyme/_coenzyme | 1.82713606 |
22 | MP0000566_synostosis | 1.82186583 |
23 | MP0003123_paternal_imprinting | 1.81157422 |
24 | MP0001764_abnormal_homeostasis | 1.78053270 |
25 | MP0003172_abnormal_lysosome_physiology | 1.69502314 |
26 | MP0009697_abnormal_copulation | 1.63365861 |
27 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.59010156 |
28 | MP0002089_abnormal_postnatal_growth/wei | 1.58479242 |
29 | MP0003011_delayed_dark_adaptation | 1.57557944 |
30 | MP0003656_abnormal_erythrocyte_physiolo | 1.57316545 |
31 | MP0005451_abnormal_body_composition | 1.48380131 |
32 | MP0001915_intracranial_hemorrhage | 1.38977324 |
33 | MP0009643_abnormal_urine_homeostasis | 1.36682124 |
34 | MP0003186_abnormal_redox_activity | 1.34750135 |
35 | MP0000598_abnormal_liver_morphology | 1.22370626 |
36 | MP0000604_amyloidosis | 1.17707265 |
37 | MP0003705_abnormal_hypodermis_morpholog | 1.13742531 |
38 | MP0010368_abnormal_lymphatic_system | 1.08898168 |
39 | MP0005636_abnormal_mineral_homeostasis | 1.08720030 |
40 | MP0002254_reproductive_system_inflammat | 1.05553631 |
41 | MP0005647_abnormal_sex_gland | 1.05246653 |
42 | MP0009764_decreased_sensitivity_to | 1.02794886 |
43 | MP0009763_increased_sensitivity_to | 1.01793800 |
44 | MP0003121_genomic_imprinting | 0.95279837 |
45 | MP0008469_abnormal_protein_level | 0.91727877 |
46 | MP0005408_hypopigmentation | 0.90860016 |
47 | * MP0009642_abnormal_blood_homeostasis | 0.89678556 |
48 | MP0006036_abnormal_mitochondrial_physio | 0.86653368 |
49 | MP0005084_abnormal_gallbladder_morpholo | 0.86475311 |
50 | MP0005376_homeostasis/metabolism_phenot | 0.84918242 |
51 | MP0003567_abnormal_fetal_cardiomyocyte | 0.82126870 |
52 | MP0006292_abnormal_olfactory_placode | 0.79151703 |
53 | MP0002078_abnormal_glucose_homeostasis | 0.78212193 |
54 | MP0009765_abnormal_xenobiotic_induced | 0.77170744 |
55 | MP0006054_spinal_hemorrhage | 0.75803865 |
56 | MP0005220_abnormal_exocrine_pancreas | 0.74108871 |
57 | MP0002876_abnormal_thyroid_physiology | 0.73435714 |
58 | MP0009053_abnormal_anal_canal | 0.73271644 |
59 | MP0005377_hearing/vestibular/ear_phenot | 0.72889586 |
60 | MP0003878_abnormal_ear_physiology | 0.72889586 |
61 | MP0005670_abnormal_white_adipose | 0.72758561 |
62 | MP0001756_abnormal_urination | 0.70549675 |
63 | MP0003315_abnormal_perineum_morphology | 0.67186230 |
64 | MP0002971_abnormal_brown_adipose | 0.66897099 |
65 | MP0001661_extended_life_span | 0.66279081 |
66 | MP0002938_white_spotting | 0.65517815 |
67 | MP0002282_abnormal_trachea_morphology | 0.65272869 |
68 | MP0005535_abnormal_body_temperature | 0.64596042 |
69 | MP0000639_abnormal_adrenal_gland | 0.64380981 |
70 | MP0003329_amyloid_beta_deposits | 0.63962712 |
71 | MP0005266_abnormal_metabolism | 0.63635463 |
72 | MP0005464_abnormal_platelet_physiology | 0.63148715 |
73 | MP0005334_abnormal_fat_pad | 0.62857710 |
74 | MP0009384_cardiac_valve_regurgitation | 0.62159413 |
75 | MP0003690_abnormal_glial_cell | 0.62083740 |
76 | MP0004130_abnormal_muscle_cell | 0.61250706 |
77 | MP0004272_abnormal_basement_membrane | 0.59069279 |
78 | MP0003879_abnormal_hair_cell | 0.57393772 |
79 | MP0003950_abnormal_plasma_membrane | 0.56231965 |
80 | MP0003718_maternal_effect | 0.56200343 |
81 | MP0005257_abnormal_intraocular_pressure | 0.55663329 |
82 | MP0005410_abnormal_fertilization | 0.55478336 |
83 | MP0002136_abnormal_kidney_physiology | 0.54700578 |
84 | MP0003943_abnormal_hepatobiliary_system | 0.53945388 |
85 | MP0005395_other_phenotype | 0.53911651 |
86 | MP0006035_abnormal_mitochondrial_morpho | 0.53843641 |
87 | MP0005448_abnormal_energy_balance | 0.51999214 |
88 | MP0005409_darkened_coat_color | 0.49668095 |
89 | MP0001324_abnormal_eye_pigmentation | 0.48800886 |
90 | MP0002933_joint_inflammation | 0.48333127 |
91 | MP0002909_abnormal_adrenal_gland | 0.47043977 |
92 | MP0003638_abnormal_response/metabolism_ | 0.46708730 |
93 | MP0008873_increased_physiological_sensi | 0.44685263 |
94 | MP0005646_abnormal_pituitary_gland | 0.44420692 |
95 | MP0003115_abnormal_respiratory_system | 0.43789782 |
96 | MP0001270_distended_abdomen | 0.43653427 |
97 | MP0009672_abnormal_birth_weight | 0.43610287 |
98 | MP0004883_abnormal_blood_vessel | 0.42889297 |
99 | MP0002160_abnormal_reproductive_system | 0.42859295 |
100 | MP0003075_altered_response_to | 0.42604921 |
101 | MP0000371_diluted_coat_color | 0.41801906 |
102 | MP0001529_abnormal_vocalization | 0.40960486 |
103 | MP0005379_endocrine/exocrine_gland_phen | 0.40915639 |
104 | MP0003436_decreased_susceptibility_to | 0.40767751 |
105 | MP0008872_abnormal_physiological_respon | 0.40593773 |
106 | MP0003183_abnormal_peptide_metabolism | 0.40552287 |
107 | MP0003953_abnormal_hormone_level | 0.40432752 |
108 | MP0002928_abnormal_bile_duct | 0.40213729 |
109 | MP0008874_decreased_physiological_sensi | 0.40207907 |
110 | MP0002822_catalepsy | 0.39283182 |
111 | MP0002249_abnormal_larynx_morphology | 0.39070226 |
112 | MP0004147_increased_porphyrin_level | 0.38592884 |
113 | MP0005076_abnormal_cell_differentiation | 0.38198629 |
114 | MP0009780_abnormal_chondrocyte_physiolo | 0.38147917 |
115 | MP0004264_abnormal_extraembryonic_tissu | 0.37698510 |
116 | MP0005666_abnormal_adipose_tissue | 0.37011285 |
117 | MP0005166_decreased_susceptibility_to | 0.36414308 |
118 | MP0002796_impaired_skin_barrier | 0.36116882 |
119 | MP0003724_increased_susceptibility_to | 0.35954017 |
120 | MP0003699_abnormal_female_reproductive | 0.35685346 |
121 | MP0004782_abnormal_surfactant_physiolog | 0.35321205 |
122 | MP0002837_dystrophic_cardiac_calcinosis | 0.35145865 |
123 | MP0001243_abnormal_dermal_layer | 0.34015620 |
124 | MP0000249_abnormal_blood_vessel | 0.33737114 |
125 | MP0002132_abnormal_respiratory_system | 0.32879862 |
126 | MP0005058_abnormal_lysosome_morphology | 0.32874051 |
127 | MP0005164_abnormal_response_to | 0.31856533 |
128 | MP0009115_abnormal_fat_cell | 0.31378232 |
129 | MP0000230_abnormal_systemic_arterial | 0.31322876 |
130 | MP0001845_abnormal_inflammatory_respons | 0.30206305 |
131 | MP0005248_abnormal_Harderian_gland | 0.29260919 |
132 | MP0002168_other_aberrant_phenotype | 0.28693524 |
133 | MP0002135_abnormal_kidney_morphology | 0.28107418 |
134 | MP0002970_abnormal_white_adipose | 0.27508275 |
135 | MP0000579_abnormal_nail_morphology | 0.26976076 |
136 | MP0005167_abnormal_blood-brain_barrier | 0.26611126 |
137 | MP0001881_abnormal_mammary_gland | 0.26134934 |
138 | MP0006082_CNS_inflammation | 0.25511575 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Deep venous thrombosis (HP:0002625) | 7.52159943 |
2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.27106318 |
3 | Intrahepatic cholestasis (HP:0001406) | 7.02706683 |
4 | Prolonged partial thromboplastin time (HP:0003645) | 6.65400678 |
5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.46309409 |
6 | Xanthomatosis (HP:0000991) | 6.35599076 |
7 | Hypobetalipoproteinemia (HP:0003563) | 6.23615199 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.38714972 |
9 | Complement deficiency (HP:0004431) | 5.14450063 |
10 | Joint hemorrhage (HP:0005261) | 5.05647535 |
11 | Hypolipoproteinemia (HP:0010981) | 4.92534307 |
12 | Hyperammonemia (HP:0001987) | 4.62274014 |
13 | Abnormality of the common coagulation pathway (HP:0010990) | 4.61434595 |
14 | Hypoalphalipoproteinemia (HP:0003233) | 4.47878036 |
15 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.45916974 |
16 | Hyperglycinemia (HP:0002154) | 4.36268175 |
17 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.26270162 |
18 | Ketosis (HP:0001946) | 4.24406046 |
19 | Epidermoid cyst (HP:0200040) | 4.24215539 |
20 | Abnormality of methionine metabolism (HP:0010901) | 4.24167127 |
21 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.24145829 |
22 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.16031987 |
23 | Hyperglycinuria (HP:0003108) | 4.03308439 |
24 | Abnormality of glycine metabolism (HP:0010895) | 3.98416758 |
25 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.98416758 |
26 | Hypoglycemic coma (HP:0001325) | 3.92927122 |
27 | Fat malabsorption (HP:0002630) | 3.92242874 |
28 | Abnormality of the intrinsic pathway (HP:0010989) | 3.85426474 |
29 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.84040121 |
30 | Abnormality of complement system (HP:0005339) | 3.75781616 |
31 | Hypercholesterolemia (HP:0003124) | 3.52468423 |
32 | Hyperbilirubinemia (HP:0002904) | 3.40810034 |
33 | Conjugated hyperbilirubinemia (HP:0002908) | 3.39944923 |
34 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.35382621 |
35 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.26905727 |
36 | Spontaneous abortion (HP:0005268) | 3.26114237 |
37 | Hypochromic microcytic anemia (HP:0004840) | 3.16324315 |
38 | Hepatocellular carcinoma (HP:0001402) | 3.11025803 |
39 | Purpura (HP:0000979) | 3.09879674 |
40 | Abnormality of nucleobase metabolism (HP:0010932) | 3.09007181 |
41 | Abnormality of serum amino acid levels (HP:0003112) | 3.06830743 |
42 | Delayed CNS myelination (HP:0002188) | 2.99510340 |
43 | Ketoacidosis (HP:0001993) | 2.94074991 |
44 | Steatorrhea (HP:0002570) | 2.89573707 |
45 | Acanthocytosis (HP:0001927) | 2.82774627 |
46 | Metabolic acidosis (HP:0001942) | 2.81275903 |
47 | Myocardial infarction (HP:0001658) | 2.76004168 |
48 | Nephritis (HP:0000123) | 2.74258198 |
49 | Abnormality of purine metabolism (HP:0004352) | 2.71490711 |
50 | Systemic lupus erythematosus (HP:0002725) | 2.69364239 |
51 | Gout (HP:0001997) | 2.69070666 |
52 | Lethargy (HP:0001254) | 2.63629671 |
53 | Dicarboxylic aciduria (HP:0003215) | 2.62982226 |
54 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.62982226 |
55 | Abnormality of carpal bone ossification (HP:0006257) | 2.60552638 |
56 | Skin nodule (HP:0200036) | 2.60097184 |
57 | Broad alveolar ridges (HP:0000187) | 2.57755493 |
58 | Amyloidosis (HP:0011034) | 2.57485590 |
59 | Small epiphyses (HP:0010585) | 2.53488028 |
60 | Abnormal tarsal ossification (HP:0008369) | 2.52583928 |
61 | Vascular calcification (HP:0004934) | 2.52486473 |
62 | Abnormal gallbladder morphology (HP:0012437) | 2.50741394 |
63 | Glomerulonephritis (HP:0000099) | 2.49962351 |
64 | Increased serum pyruvate (HP:0003542) | 2.48344470 |
65 | Hypoglycemic seizures (HP:0002173) | 2.48323297 |
66 | Cerebral edema (HP:0002181) | 2.47897634 |
67 | Cholelithiasis (HP:0001081) | 2.46713995 |
68 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.44360320 |
69 | Spastic diplegia (HP:0001264) | 2.42525883 |
70 | Gingival bleeding (HP:0000225) | 2.39319568 |
71 | Irritability (HP:0000737) | 2.37477686 |
72 | Abnormal gallbladder physiology (HP:0012438) | 2.35052146 |
73 | Cholecystitis (HP:0001082) | 2.35052146 |
74 | Neonatal onset (HP:0003623) | 2.34177827 |
75 | Osteomalacia (HP:0002749) | 2.33361217 |
76 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.30502043 |
77 | Poikilocytosis (HP:0004447) | 2.30192354 |
78 | Mitral stenosis (HP:0001718) | 2.26807441 |
79 | Thrombophlebitis (HP:0004418) | 2.25472401 |
80 | Menorrhagia (HP:0000132) | 2.24275083 |
81 | Cardiovascular calcification (HP:0011915) | 2.23314826 |
82 | Enlarged kidneys (HP:0000105) | 2.22500743 |
83 | Vaginal fistula (HP:0004320) | 2.21783230 |
84 | Abnormality of glycolysis (HP:0004366) | 2.21436216 |
85 | Esophageal varix (HP:0002040) | 2.20242761 |
86 | Malnutrition (HP:0004395) | 2.20079398 |
87 | Pancreatitis (HP:0001733) | 2.17853558 |
88 | Generalized aminoaciduria (HP:0002909) | 2.17585029 |
89 | Facial shape deformation (HP:0011334) | 2.17485483 |
90 | Potter facies (HP:0002009) | 2.17485483 |
91 | Pulmonary embolism (HP:0002204) | 2.15547798 |
92 | Arthropathy (HP:0003040) | 2.13315975 |
93 | Vomiting (HP:0002013) | 2.13003032 |
94 | Sensorimotor neuropathy (HP:0007141) | 2.07504502 |
95 | Brushfield spots (HP:0001088) | 2.06108246 |
96 | Abnormality of the gallbladder (HP:0005264) | 2.03721419 |
97 | Hepatoblastoma (HP:0002884) | 2.02969535 |
98 | Late onset (HP:0003584) | 2.01968167 |
99 | Abnormality of iron homeostasis (HP:0011031) | 2.00648802 |
100 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.00215632 |
101 | Rickets (HP:0002748) | 1.99240826 |
102 | Hemorrhage of the eye (HP:0011885) | 1.99153565 |
103 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.98991781 |
104 | Opisthotonus (HP:0002179) | 1.93710158 |
105 | Confusion (HP:0001289) | 1.93247266 |
106 | Alkalosis (HP:0001948) | 1.91705918 |
107 | Abnormality of the nasal septum (HP:0000419) | 1.91625701 |
108 | Abnormality of proline metabolism (HP:0010907) | 1.91008081 |
109 | Hydroxyprolinuria (HP:0003080) | 1.91008081 |
110 | Broad palm (HP:0001169) | 1.90533005 |
111 | Flat acetabular roof (HP:0003180) | 1.90140485 |
112 | Abnormal hand bone ossification (HP:0010660) | 1.89921010 |
113 | Proximal tubulopathy (HP:0000114) | 1.88929425 |
114 | Abnormal cartilage morphology (HP:0002763) | 1.88830534 |
115 | Pigmentary retinal degeneration (HP:0001146) | 1.87567883 |
116 | Epistaxis (HP:0000421) | 1.87301909 |
117 | Hypophosphatemic rickets (HP:0004912) | 1.86881442 |
118 | Abnormality of the lumbar spine (HP:0100712) | 1.85054417 |
119 | Reticulocytosis (HP:0001923) | 1.83931996 |
120 | Abnormal ossification of hand bones (HP:0005921) | 1.83055448 |
121 | Diastasis recti (HP:0001540) | 1.82824489 |
122 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.81315828 |
123 | Increased purine levels (HP:0004368) | 1.80324580 |
124 | Hyperuricemia (HP:0002149) | 1.80324580 |
125 | Widely patent fontanelles and sutures (HP:0004492) | 1.79789264 |
126 | Elevated hepatic transaminases (HP:0002910) | 1.79264595 |
127 | Abnormality of the Achilles tendon (HP:0005109) | 1.75365543 |
128 | Increased serum ferritin (HP:0003281) | 1.75107192 |
129 | Alacrima (HP:0000522) | 1.67768878 |
130 | Epiphyseal dysplasia (HP:0002656) | 1.67586400 |
131 | Joint swelling (HP:0001386) | 1.67369491 |
132 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.66868827 |
133 | Bifid scrotum (HP:0000048) | 1.66867441 |
134 | Gangrene (HP:0100758) | 1.66786089 |
135 | Neoplasm of the liver (HP:0002896) | 1.61770672 |
136 | Asymmetry of the thorax (HP:0001555) | 1.60595503 |
137 | Abnormal delivery (HP:0001787) | 1.57281396 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 7.64422679 |
2 | FGFR4 | 4.66308351 |
3 | ERN1 | 4.32402199 |
4 | SIK1 | 4.22836230 |
5 | WNK4 | 4.07444764 |
6 | TAOK3 | 2.85723038 |
7 | INSRR | 2.85569918 |
8 | ERBB4 | 2.80130937 |
9 | TYRO3 | 2.52826154 |
10 | CDK12 | 2.46433438 |
11 | PIK3CA | 2.27371329 |
12 | PKN2 | 2.23662044 |
13 | MST1R | 2.20133652 |
14 | MAP2K4 | 2.18385029 |
15 | FGFR1 | 2.13258504 |
16 | MAPK11 | 2.09669897 |
17 | TRIB3 | 1.95056656 |
18 | FLT3 | 1.92325987 |
19 | TYK2 | 1.79220138 |
20 | DAPK2 | 1.67792551 |
21 | PIK3CG | 1.66047618 |
22 | SIK2 | 1.62055370 |
23 | AKT3 | 1.59845661 |
24 | PTK6 | 1.54225605 |
25 | PDGFRA | 1.54123005 |
26 | ABL2 | 1.53686285 |
27 | KDR | 1.51413269 |
28 | LATS1 | 1.50005859 |
29 | NEK9 | 1.42297260 |
30 | GRK6 | 1.39923474 |
31 | WNK1 | 1.38692397 |
32 | PDK2 | 1.38142408 |
33 | BRSK2 | 1.36263727 |
34 | JAK2 | 1.24731745 |
35 | MAP2K3 | 1.21556084 |
36 | PINK1 | 1.16594576 |
37 | CDK7 | 1.14213734 |
38 | MAP3K11 | 1.09683183 |
39 | PRKAA2 | 1.09655956 |
40 | MAP3K10 | 1.08706111 |
41 | FRK | 1.06154680 |
42 | FGFR2 | 1.05077455 |
43 | ERBB2 | 1.04417630 |
44 | MAP3K3 | 1.04413409 |
45 | MAP3K2 | 1.02084443 |
46 | STK38L | 1.00702921 |
47 | MAP3K7 | 1.00391902 |
48 | MET | 0.97463825 |
49 | NEK2 | 0.97239246 |
50 | TBK1 | 0.96509535 |
51 | DDR2 | 0.95840574 |
52 | BRSK1 | 0.95774071 |
53 | MATK | 0.95170864 |
54 | EEF2K | 0.95151406 |
55 | MAPK4 | 0.93897241 |
56 | RPS6KB1 | 0.91995077 |
57 | TIE1 | 0.90532575 |
58 | EPHB1 | 0.90399564 |
59 | JAK1 | 0.87970346 |
60 | PRKCZ | 0.85915806 |
61 | FGR | 0.85329060 |
62 | MAPK12 | 0.81536229 |
63 | PRKACG | 0.80506667 |
64 | NTRK3 | 0.79815984 |
65 | CSNK1E | 0.77599561 |
66 | CDK6 | 0.76759253 |
67 | DYRK1B | 0.76492418 |
68 | MAP3K14 | 0.71919628 |
69 | EPHA3 | 0.70673751 |
70 | PTK2 | 0.70005088 |
71 | SGK1 | 0.69077767 |
72 | GSK3A | 0.69014759 |
73 | TGFBR2 | 0.68869971 |
74 | CAMK2G | 0.67997973 |
75 | PRKAA1 | 0.65794406 |
76 | MAPK15 | 0.65376336 |
77 | TAOK2 | 0.62496640 |
78 | CSK | 0.62321130 |
79 | CDK8 | 0.61544332 |
80 | MAP2K6 | 0.61421330 |
81 | CSNK2A2 | 0.58649800 |
82 | NLK | 0.57364352 |
83 | RIPK1 | 0.56653503 |
84 | PBK | 0.54968279 |
85 | SGK3 | 0.54419754 |
86 | MUSK | 0.54148719 |
87 | PDPK1 | 0.54075039 |
88 | CSNK2A1 | 0.52660152 |
89 | MAPKAPK3 | 0.51687170 |
90 | IRAK3 | 0.51501106 |
91 | CDK4 | 0.50747620 |
92 | CSF1R | 0.50153962 |
93 | GRK1 | 0.48592192 |
94 | MAP2K1 | 0.46529330 |
95 | CSNK1D | 0.46029090 |
96 | NME1 | 0.45446918 |
97 | MAPK7 | 0.45318285 |
98 | BCR | 0.45048945 |
99 | IKBKE | 0.44376723 |
100 | PRKCQ | 0.44319551 |
101 | WNK3 | 0.44172361 |
102 | EIF2AK3 | 0.44086641 |
103 | PRKCG | 0.43068802 |
104 | MAP3K5 | 0.42791583 |
105 | CAMK1D | 0.41855661 |
106 | CSNK1G1 | 0.41118668 |
107 | NEK1 | 0.39473934 |
108 | FGFR3 | 0.37869385 |
109 | IGF1R | 0.37363988 |
110 | MTOR | 0.36720071 |
111 | SMG1 | 0.36397794 |
112 | EIF2AK1 | 0.36013171 |
113 | SRC | 0.35929456 |
114 | SGK2 | 0.35468732 |
115 | PRKG1 | 0.35110902 |
116 | EPHA4 | 0.34978780 |
117 | SGK494 | 0.34730880 |
118 | SGK223 | 0.34730880 |
119 | RPS6KA3 | 0.34508731 |
120 | PDK1 | 0.33280619 |
121 | TRPM7 | 0.32731233 |
122 | STK16 | 0.32456731 |
123 | MAP3K6 | 0.32425341 |
124 | CDC42BPA | 0.32377904 |
125 | EGFR | 0.32194539 |
126 | STK39 | 0.31761406 |
127 | MAPK3 | 0.31310784 |
128 | KSR2 | 0.31063242 |
129 | LATS2 | 0.31053934 |
130 | RET | 0.30837628 |
131 | PKN1 | 0.30543289 |
132 | MAP3K1 | 0.29914759 |
133 | EPHA2 | 0.29184057 |
134 | MAP2K2 | 0.27821097 |
135 | TTK | 0.27735048 |
136 | CAMK4 | 0.27638810 |
137 | ICK | 0.27522629 |
138 | PRKCA | 0.26168707 |
139 | MAP3K13 | 0.25137225 |
140 | ITK | 0.24430886 |
141 | CDK1 | 0.24245906 |
142 | PRKCB | 0.24144427 |
143 | PAK3 | 0.24014722 |
144 | PRKACA | 0.22401153 |
145 | MAP4K1 | 0.21804296 |
146 | PDK3 | 0.20679037 |
147 | PDK4 | 0.20679037 |
148 | PRKACB | 0.20381511 |
149 | CSNK1G3 | 0.18728025 |
150 | BMX | 0.18685262 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.39605265 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.65492564 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.40595780 |
4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.27130450 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.10753422 |
6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.88773611 |
7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.73591257 |
8 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.66482778 |
9 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.63665139 |
10 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.59990744 |
11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.48736110 |
12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.37865620 |
13 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.18335759 |
14 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.16753884 |
15 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.06917120 |
16 | Peroxisome_Homo sapiens_hsa04146 | 2.05979248 |
17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.92384777 |
18 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.89315517 |
19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.87146015 |
20 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.85692874 |
21 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.85223561 |
22 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.80804192 |
23 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.79586641 |
24 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.78500974 |
25 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.74977237 |
26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.72442442 |
27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.69607026 |
28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.66900708 |
29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.61972528 |
30 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.60451672 |
31 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.60345966 |
32 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.59057109 |
33 | Retinol metabolism_Homo sapiens_hsa00830 | 1.57428660 |
34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.56151291 |
35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.50389788 |
36 | Bile secretion_Homo sapiens_hsa04976 | 1.43077421 |
37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.39995579 |
38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.38752430 |
39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.37025176 |
40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.37018238 |
41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.33988293 |
42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.30923711 |
43 | Other glycan degradation_Homo sapiens_hsa00511 | 1.28703125 |
44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.27460419 |
45 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.25928717 |
46 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.25597472 |
47 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.22374208 |
48 | Carbon metabolism_Homo sapiens_hsa01200 | 1.18317958 |
49 | ABC transporters_Homo sapiens_hsa02010 | 1.12926338 |
50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.10861319 |
51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.10057611 |
52 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.09774055 |
53 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.03757353 |
54 | Sulfur relay system_Homo sapiens_hsa04122 | 1.02523682 |
55 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.02479450 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.02443239 |
57 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.99949375 |
58 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.87755975 |
59 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.86356819 |
60 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.83528961 |
61 | Lysine degradation_Homo sapiens_hsa00310 | 0.80922251 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.73606636 |
63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.72977385 |
64 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.66381533 |
65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.64712747 |
66 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.57150947 |
67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53283061 |
68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48086914 |
69 | Pertussis_Homo sapiens_hsa05133 | 0.45928984 |
70 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.45246774 |
71 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37045896 |
72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.31531889 |
73 | Prion diseases_Homo sapiens_hsa05020 | 0.31221772 |
74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.29565533 |
75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.27755916 |
76 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.26216572 |
77 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.24356480 |
78 | Insulin resistance_Homo sapiens_hsa04931 | 0.20646510 |
79 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.20553495 |
80 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.19694572 |
81 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.18371052 |
82 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.15893993 |
83 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.08003645 |
84 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.00996656 |
85 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.00486930 |
86 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.00252986 |
87 | Mineral absorption_Homo sapiens_hsa04978 | -0.2590277 |
88 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.2582568 |
89 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.2289231 |
90 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.2281948 |
91 | Bladder cancer_Homo sapiens_hsa05219 | -0.2230290 |
92 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1867600 |
93 | Hepatitis C_Homo sapiens_hsa05160 | -0.1808432 |
94 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1755721 |
95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1741546 |
96 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1713147 |
97 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | -0.1554076 |
98 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1492153 |
99 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1464549 |
100 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1400831 |
101 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1392725 |
102 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | -0.1353987 |
103 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | -0.1308535 |
104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1296005 |
105 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1272999 |
106 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1236253 |
107 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0867826 |
108 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.0721437 |
109 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0258390 |