APOM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.48563104
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.48563104
3L-phenylalanine metabolic process (GO:0006558)7.21195224
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21195224
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.73451576
6aromatic amino acid family catabolic process (GO:0009074)6.65493562
7intestinal cholesterol absorption (GO:0030299)6.19126601
8negative regulation of fibrinolysis (GO:0051918)6.10718991
9glyoxylate metabolic process (GO:0046487)6.04505861
10tryptophan catabolic process (GO:0006569)5.93102012
11indole-containing compound catabolic process (GO:0042436)5.93102012
12indolalkylamine catabolic process (GO:0046218)5.93102012
13kynurenine metabolic process (GO:0070189)5.85881498
14regulation of fibrinolysis (GO:0051917)5.83834399
15bile acid biosynthetic process (GO:0006699)5.75294755
16urea cycle (GO:0000050)5.63777092
17urea metabolic process (GO:0019627)5.63777092
18* high-density lipoprotein particle remodeling (GO:0034375)5.61058097
19tryptophan metabolic process (GO:0006568)5.60955765
20protein carboxylation (GO:0018214)5.46889255
21peptidyl-glutamic acid carboxylation (GO:0017187)5.46889255
22sulfur amino acid catabolic process (GO:0000098)5.43228268
23cysteine metabolic process (GO:0006534)5.37637191
24* protein-lipid complex subunit organization (GO:0071825)5.37616689
25regulation of protein activation cascade (GO:2000257)5.36348571
26regulation of cholesterol esterification (GO:0010872)5.33668661
27alpha-linolenic acid metabolic process (GO:0036109)5.27592991
28complement activation, alternative pathway (GO:0006957)5.21181585
29serine family amino acid catabolic process (GO:0009071)5.19504721
30nitrogen cycle metabolic process (GO:0071941)5.17937451
31regulation of apoptotic cell clearance (GO:2000425)5.11999925
32regulation of triglyceride catabolic process (GO:0010896)5.06166705
33* reverse cholesterol transport (GO:0043691)5.01815074
34phospholipid efflux (GO:0033700)4.99203615
35regulation of complement activation (GO:0030449)4.96301785
36bile acid metabolic process (GO:0008206)4.90998989
37* protein-lipid complex remodeling (GO:0034368)4.89754202
38* macromolecular complex remodeling (GO:0034367)4.89754202
39* plasma lipoprotein particle remodeling (GO:0034369)4.89754202
40aromatic amino acid family metabolic process (GO:0009072)4.86508655
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80005017
42acylglycerol homeostasis (GO:0055090)4.77710768
43triglyceride homeostasis (GO:0070328)4.77710768
44tyrosine metabolic process (GO:0006570)4.74252484
45homocysteine metabolic process (GO:0050667)4.74243614
46proline metabolic process (GO:0006560)4.69827618
47negative regulation of sterol transport (GO:0032372)4.67904014
48negative regulation of cholesterol transport (GO:0032375)4.67904014
49lysine metabolic process (GO:0006553)4.63803673
50lysine catabolic process (GO:0006554)4.63803673
51amino-acid betaine metabolic process (GO:0006577)4.61820863
52alpha-amino acid catabolic process (GO:1901606)4.60060755
53cellular ketone body metabolic process (GO:0046950)4.52825063
54glycine metabolic process (GO:0006544)4.49314246
55* plasma lipoprotein particle clearance (GO:0034381)4.46482297
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.42819875
57epoxygenase P450 pathway (GO:0019373)4.41087378
58negative regulation of hemostasis (GO:1900047)4.38806441
59negative regulation of blood coagulation (GO:0030195)4.38806441
60positive regulation of fatty acid biosynthetic process (GO:0045723)4.38415133
61positive regulation of hemostasis (GO:1900048)4.37937029
62positive regulation of blood coagulation (GO:0030194)4.37937029
63regulation of humoral immune response (GO:0002920)4.29287538
64serine family amino acid metabolic process (GO:0009069)4.27515895
65cellular amino acid catabolic process (GO:0009063)4.25608318
66fibrinolysis (GO:0042730)4.25468986
67* cholesterol efflux (GO:0033344)4.25185293
68glutamate metabolic process (GO:0006536)4.23860878
69indolalkylamine metabolic process (GO:0006586)4.20723226
70imidazole-containing compound metabolic process (GO:0052803)4.19863058
71serine family amino acid biosynthetic process (GO:0009070)4.19201146
72blood coagulation, intrinsic pathway (GO:0007597)4.16378717
73bile acid and bile salt transport (GO:0015721)4.15707594
74positive regulation of lipoprotein lipase activity (GO:0051006)4.13354529
75positive regulation of triglyceride lipase activity (GO:0061365)4.13354529
76low-density lipoprotein particle remodeling (GO:0034374)4.12943568
77cellular modified amino acid catabolic process (GO:0042219)4.12237027
78coenzyme catabolic process (GO:0009109)4.12015438
79cellular biogenic amine catabolic process (GO:0042402)4.11578150
80amine catabolic process (GO:0009310)4.11578150
81arginine metabolic process (GO:0006525)4.09529731
82aldehyde catabolic process (GO:0046185)4.08354584
83benzene-containing compound metabolic process (GO:0042537)4.03203950
84negative regulation of coagulation (GO:0050819)4.02566632
85dicarboxylic acid biosynthetic process (GO:0043650)4.01052222
86* plasma lipoprotein particle assembly (GO:0034377)3.98959260
87positive regulation of coagulation (GO:0050820)3.98435801
88intestinal absorption (GO:0050892)3.97536790
89diacylglycerol metabolic process (GO:0046339)3.97529838
90drug catabolic process (GO:0042737)3.95795575
91* cholesterol transport (GO:0030301)3.95438450
92* sterol transport (GO:0015918)3.95438450
93cellular glucuronidation (GO:0052695)3.95006918
94phospholipid homeostasis (GO:0055091)3.92014526
95ketone body metabolic process (GO:1902224)3.91779112
96negative regulation of lipase activity (GO:0060192)3.87765446
97positive regulation of lipid catabolic process (GO:0050996)3.87294259
98very-low-density lipoprotein particle assembly (GO:0034379)3.85131985
99ethanol oxidation (GO:0006069)3.82438948
100negative regulation of wound healing (GO:0061045)3.80137876
101regulation of plasminogen activation (GO:0010755)3.79956285
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79139419
103cofactor catabolic process (GO:0051187)3.78916993
104* cholesterol homeostasis (GO:0042632)3.78248156
105ethanol metabolic process (GO:0006067)3.77355485
106regulation of cholesterol homeostasis (GO:2000188)3.76285397
107positive regulation of steroid metabolic process (GO:0045940)3.75724548
108protein activation cascade (GO:0072376)3.75620079
109* plasma lipoprotein particle organization (GO:0071827)3.73124422
110organic acid catabolic process (GO:0016054)3.72013912
111carboxylic acid catabolic process (GO:0046395)3.72013912
112* sterol homeostasis (GO:0055092)3.71989225
113omega-hydroxylase P450 pathway (GO:0097267)3.71309295
114exogenous drug catabolic process (GO:0042738)3.71299252
115heme transport (GO:0015886)3.69949578
116negative regulation of complement activation (GO:0045916)3.69711397
117acute-phase response (GO:0006953)3.66981087
118regulation of cholesterol biosynthetic process (GO:0045540)3.65849529
119short-chain fatty acid metabolic process (GO:0046459)3.64908415
120complement activation, classical pathway (GO:0006958)3.64080915
121negative regulation of protein activation cascade (GO:2000258)3.63880684
122complement activation (GO:0006956)3.62965870
123cytolysis (GO:0019835)3.58766433
124peptidyl-glutamic acid modification (GO:0018200)3.57674842
125* protein-lipid complex assembly (GO:0065005)3.55511209
126NAD biosynthetic process (GO:0009435)3.54377011
127* lipoprotein metabolic process (GO:0042157)3.54127915
128regulation of bile acid biosynthetic process (GO:0070857)3.53665243
129acetyl-CoA metabolic process (GO:0006084)3.52904889
130proline biosynthetic process (GO:0006561)3.40635395
131acute inflammatory response (GO:0002526)3.40180030
132acylglycerol catabolic process (GO:0046464)3.36791942
133neutral lipid catabolic process (GO:0046461)3.36791942
134positive regulation of extracellular matrix organization (GO:1903055)3.36556830
135glutamine family amino acid biosynthetic process (GO:0009084)3.32227588
136* lipid homeostasis (GO:0055088)3.29001676
137regulation of lipoprotein particle clearance (GO:0010984)3.28250167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.39507685
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21720457
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.97504057
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47039238
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.28781148
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23050190
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98198855
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10868952
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92579557
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60425451
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24075991
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13733684
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05912708
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.2195779
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98134144
16GATA1_22025678_ChIP-Seq_K562_Human1.64354982
17CLOCK_20551151_ChIP-Seq_293T_Human1.60051195
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.59993766
19HTT_18923047_ChIP-ChIP_STHdh_Human1.47863527
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.43205797
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42581389
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37588305
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.31469325
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26810948
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23144667
26AR_21909140_ChIP-Seq_LNCAP_Human1.22825878
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19555518
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16385870
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09732353
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01676483
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00446214
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99982191
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93777414
34ZNF263_19887448_ChIP-Seq_K562_Human0.91761033
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90567491
36SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90387951
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86503227
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85801928
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84118291
40SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83355130
41GATA4_25053715_ChIP-Seq_YYC3_Human0.82445154
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82165631
43SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81532040
44RARA_24833708_ChIP-Seq_LIVER_Mouse0.79739157
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.79430411
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78157586
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77406493
48* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75217525
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74796053
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74339112
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73205716
52SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71634136
53* RAC3_21632823_ChIP-Seq_H3396_Human0.71396744
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70956000
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70754367
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68453932
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67444572
58ELF1_20517297_ChIP-Seq_JURKAT_Human0.66533928
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66394742
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65983936
61RARB_24833708_ChIP-Seq_LIVER_Mouse0.65975714
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65944739
63NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65557393
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65202094
65STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65183117
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.65050569
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63593708
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.61295977
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.61132638
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61060309
71SOX11_22085726_ChIP-Seq_ESNs_Mouse0.60516957
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60246008
73NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.60017780
74LXR_22292898_ChIP-Seq_THP-1_Human0.59574051
75SOX17_20123909_ChIP-Seq_XEN_Mouse0.59226070
76CSB_26484114_Chip-Seq_FIBROBLAST_Human0.58776453
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58027702
78SOX2_20726797_ChIP-Seq_SW620_Human0.57899834
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57796184
80GATA1_19941826_ChIP-Seq_K562_Human0.57126321
81E2F1_20622854_ChIP-Seq_HELA_Human0.56899131
82SOX2_22085726_ChIP-Seq_NPCs_Mouse0.56775341
83EGR1_19032775_ChIP-ChIP_M12_Human0.55937868
84* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55286641
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55104188
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.55056294
87SOX2_21211035_ChIP-Seq_LN229_Human0.54436502
88* CEBPB_22108803_ChIP-Seq_LS180_Human0.53933942
89AR_20517297_ChIP-Seq_VCAP_Human0.53811999
90P68_20966046_ChIP-Seq_HELA_Human0.53558999
91MYC_19915707_ChIP-ChIP_AK7_Human0.53338358
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50907536
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50907536
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.50777894
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50129603
96SMC4_20622854_ChIP-Seq_HELA_Human0.50046131
97SMAD1_18555785_Chip-Seq_ESCs_Mouse0.49862110
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.48939870
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48853187
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.48384186
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48228133
102MYC_19829295_ChIP-Seq_ESCs_Human0.48124568
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48042806
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47981657
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.47776721
106SPI1_20517297_ChIP-Seq_HL60_Human0.47520286
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.47280643
108JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.47246771
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.46597893
110GATA2_19941826_ChIP-Seq_K562_Human0.45875867
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.44857714
112CBP_21632823_ChIP-Seq_H3396_Human0.44528182
113GATA6_25053715_ChIP-Seq_YYC3_Human0.43658715
114* TAF2_19829295_ChIP-Seq_ESCs_Human0.43528891
115* P53_21459846_ChIP-Seq_SAOS-2_Human0.43459069
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.42789447
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42507866
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42161685
119STAT1_17558387_ChIP-Seq_HELA_Human0.40189666
120* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40048828
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40023035
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.39414918
123STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38743877
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.38648940
125SPI1_26923725_Chip-Seq_HPCs_Mouse0.38164552
126BCOR_27268052_Chip-Seq_Bcells_Human0.38033584
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37622445
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.37378677
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.37236454
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37076106
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.36878774
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36606042
133ERG_20517297_ChIP-Seq_VCAP_Human0.35839605
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.35411117
135OCT4_20526341_ChIP-Seq_ESCs_Human0.35363819
136SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34666827
137FOXH1_21741376_ChIP-Seq_EPCs_Human0.34316720
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.34296668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12964286
2MP0005360_urolithiasis7.65040418
3MP0005085_abnormal_gallbladder_physiolo6.28412110
4MP0005365_abnormal_bile_salt6.12105492
5MP0008875_abnormal_xenobiotic_pharmacok4.95663744
6MP0003806_abnormal_nucleotide_metabolis4.15031390
7MP0003252_abnormal_bile_duct3.76508869
8* MP0010329_abnormal_lipoprotein_level3.54016643
9MP0009840_abnormal_foam_cell3.53858789
10MP0003122_maternal_imprinting3.45455388
11MP0005083_abnormal_biliary_tract3.06657928
12MP0005332_abnormal_amino_acid2.87088383
13MP0003195_calcinosis2.84428119
14MP0003191_abnormal_cellular_cholesterol2.70716462
15MP0001666_abnormal_nutrient_absorption2.56829580
16MP0004019_abnormal_vitamin_homeostasis2.34615453
17MP0000609_abnormal_liver_physiology2.18455243
18* MP0002118_abnormal_lipid_homeostasis2.05878836
19MP0002138_abnormal_hepatobiliary_system2.04177419
20MP0003868_abnormal_feces_composition1.84679282
21MP0005319_abnormal_enzyme/_coenzyme1.82713606
22MP0000566_synostosis1.82186583
23MP0003123_paternal_imprinting1.81157422
24MP0001764_abnormal_homeostasis1.78053270
25MP0003172_abnormal_lysosome_physiology1.69502314
26MP0009697_abnormal_copulation1.63365861
27MP0005584_abnormal_enzyme/coenzyme_acti1.59010156
28MP0002089_abnormal_postnatal_growth/wei1.58479242
29MP0003011_delayed_dark_adaptation1.57557944
30MP0003656_abnormal_erythrocyte_physiolo1.57316545
31MP0005451_abnormal_body_composition1.48380131
32MP0001915_intracranial_hemorrhage1.38977324
33MP0009643_abnormal_urine_homeostasis1.36682124
34MP0003186_abnormal_redox_activity1.34750135
35MP0000598_abnormal_liver_morphology1.22370626
36MP0000604_amyloidosis1.17707265
37MP0003705_abnormal_hypodermis_morpholog1.13742531
38MP0010368_abnormal_lymphatic_system1.08898168
39MP0005636_abnormal_mineral_homeostasis1.08720030
40MP0002254_reproductive_system_inflammat1.05553631
41MP0005647_abnormal_sex_gland1.05246653
42MP0009764_decreased_sensitivity_to1.02794886
43MP0009763_increased_sensitivity_to1.01793800
44MP0003121_genomic_imprinting0.95279837
45MP0008469_abnormal_protein_level0.91727877
46MP0005408_hypopigmentation0.90860016
47* MP0009642_abnormal_blood_homeostasis0.89678556
48MP0006036_abnormal_mitochondrial_physio0.86653368
49MP0005084_abnormal_gallbladder_morpholo0.86475311
50MP0005376_homeostasis/metabolism_phenot0.84918242
51MP0003567_abnormal_fetal_cardiomyocyte0.82126870
52MP0006292_abnormal_olfactory_placode0.79151703
53MP0002078_abnormal_glucose_homeostasis0.78212193
54MP0009765_abnormal_xenobiotic_induced0.77170744
55MP0006054_spinal_hemorrhage0.75803865
56MP0005220_abnormal_exocrine_pancreas0.74108871
57MP0002876_abnormal_thyroid_physiology0.73435714
58MP0009053_abnormal_anal_canal0.73271644
59MP0005377_hearing/vestibular/ear_phenot0.72889586
60MP0003878_abnormal_ear_physiology0.72889586
61MP0005670_abnormal_white_adipose0.72758561
62MP0001756_abnormal_urination0.70549675
63MP0003315_abnormal_perineum_morphology0.67186230
64MP0002971_abnormal_brown_adipose0.66897099
65MP0001661_extended_life_span0.66279081
66MP0002938_white_spotting0.65517815
67MP0002282_abnormal_trachea_morphology0.65272869
68MP0005535_abnormal_body_temperature0.64596042
69MP0000639_abnormal_adrenal_gland0.64380981
70MP0003329_amyloid_beta_deposits0.63962712
71MP0005266_abnormal_metabolism0.63635463
72MP0005464_abnormal_platelet_physiology0.63148715
73MP0005334_abnormal_fat_pad0.62857710
74MP0009384_cardiac_valve_regurgitation0.62159413
75MP0003690_abnormal_glial_cell0.62083740
76MP0004130_abnormal_muscle_cell0.61250706
77MP0004272_abnormal_basement_membrane0.59069279
78MP0003879_abnormal_hair_cell0.57393772
79MP0003950_abnormal_plasma_membrane0.56231965
80MP0003718_maternal_effect0.56200343
81MP0005257_abnormal_intraocular_pressure0.55663329
82MP0005410_abnormal_fertilization0.55478336
83MP0002136_abnormal_kidney_physiology0.54700578
84MP0003943_abnormal_hepatobiliary_system0.53945388
85MP0005395_other_phenotype0.53911651
86MP0006035_abnormal_mitochondrial_morpho0.53843641
87MP0005448_abnormal_energy_balance0.51999214
88MP0005409_darkened_coat_color0.49668095
89MP0001324_abnormal_eye_pigmentation0.48800886
90MP0002933_joint_inflammation0.48333127
91MP0002909_abnormal_adrenal_gland0.47043977
92MP0003638_abnormal_response/metabolism_0.46708730
93MP0008873_increased_physiological_sensi0.44685263
94MP0005646_abnormal_pituitary_gland0.44420692
95MP0003115_abnormal_respiratory_system0.43789782
96MP0001270_distended_abdomen0.43653427
97MP0009672_abnormal_birth_weight0.43610287
98MP0004883_abnormal_blood_vessel0.42889297
99MP0002160_abnormal_reproductive_system0.42859295
100MP0003075_altered_response_to0.42604921
101MP0000371_diluted_coat_color0.41801906
102MP0001529_abnormal_vocalization0.40960486
103MP0005379_endocrine/exocrine_gland_phen0.40915639
104MP0003436_decreased_susceptibility_to0.40767751
105MP0008872_abnormal_physiological_respon0.40593773
106MP0003183_abnormal_peptide_metabolism0.40552287
107MP0003953_abnormal_hormone_level0.40432752
108MP0002928_abnormal_bile_duct0.40213729
109MP0008874_decreased_physiological_sensi0.40207907
110MP0002822_catalepsy0.39283182
111MP0002249_abnormal_larynx_morphology0.39070226
112MP0004147_increased_porphyrin_level0.38592884
113MP0005076_abnormal_cell_differentiation0.38198629
114MP0009780_abnormal_chondrocyte_physiolo0.38147917
115MP0004264_abnormal_extraembryonic_tissu0.37698510
116MP0005666_abnormal_adipose_tissue0.37011285
117MP0005166_decreased_susceptibility_to0.36414308
118MP0002796_impaired_skin_barrier0.36116882
119MP0003724_increased_susceptibility_to0.35954017
120MP0003699_abnormal_female_reproductive0.35685346
121MP0004782_abnormal_surfactant_physiolog0.35321205
122MP0002837_dystrophic_cardiac_calcinosis0.35145865
123MP0001243_abnormal_dermal_layer0.34015620
124MP0000249_abnormal_blood_vessel0.33737114
125MP0002132_abnormal_respiratory_system0.32879862
126MP0005058_abnormal_lysosome_morphology0.32874051
127MP0005164_abnormal_response_to0.31856533
128MP0009115_abnormal_fat_cell0.31378232
129MP0000230_abnormal_systemic_arterial0.31322876
130MP0001845_abnormal_inflammatory_respons0.30206305
131MP0005248_abnormal_Harderian_gland0.29260919
132MP0002168_other_aberrant_phenotype0.28693524
133MP0002135_abnormal_kidney_morphology0.28107418
134MP0002970_abnormal_white_adipose0.27508275
135MP0000579_abnormal_nail_morphology0.26976076
136MP0005167_abnormal_blood-brain_barrier0.26611126
137MP0001881_abnormal_mammary_gland0.26134934
138MP0006082_CNS_inflammation0.25511575

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.52159943
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27106318
3Intrahepatic cholestasis (HP:0001406)7.02706683
4Prolonged partial thromboplastin time (HP:0003645)6.65400678
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46309409
6Xanthomatosis (HP:0000991)6.35599076
7Hypobetalipoproteinemia (HP:0003563)6.23615199
8Hyperlipoproteinemia (HP:0010980)5.38714972
9Complement deficiency (HP:0004431)5.14450063
10Joint hemorrhage (HP:0005261)5.05647535
11Hypolipoproteinemia (HP:0010981)4.92534307
12Hyperammonemia (HP:0001987)4.62274014
13Abnormality of the common coagulation pathway (HP:0010990)4.61434595
14Hypoalphalipoproteinemia (HP:0003233)4.47878036
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45916974
16Hyperglycinemia (HP:0002154)4.36268175
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.26270162
18Ketosis (HP:0001946)4.24406046
19Epidermoid cyst (HP:0200040)4.24215539
20Abnormality of methionine metabolism (HP:0010901)4.24167127
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.24145829
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.16031987
23Hyperglycinuria (HP:0003108)4.03308439
24Abnormality of glycine metabolism (HP:0010895)3.98416758
25Abnormality of serine family amino acid metabolism (HP:0010894)3.98416758
26Hypoglycemic coma (HP:0001325)3.92927122
27Fat malabsorption (HP:0002630)3.92242874
28Abnormality of the intrinsic pathway (HP:0010989)3.85426474
29Abnormality of pyrimidine metabolism (HP:0004353)3.84040121
30Abnormality of complement system (HP:0005339)3.75781616
31Hypercholesterolemia (HP:0003124)3.52468423
32Hyperbilirubinemia (HP:0002904)3.40810034
33Conjugated hyperbilirubinemia (HP:0002908)3.39944923
34Abnormality of fatty-acid metabolism (HP:0004359)3.35382621
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26905727
36Spontaneous abortion (HP:0005268)3.26114237
37Hypochromic microcytic anemia (HP:0004840)3.16324315
38Hepatocellular carcinoma (HP:0001402)3.11025803
39Purpura (HP:0000979)3.09879674
40Abnormality of nucleobase metabolism (HP:0010932)3.09007181
41Abnormality of serum amino acid levels (HP:0003112)3.06830743
42Delayed CNS myelination (HP:0002188)2.99510340
43Ketoacidosis (HP:0001993)2.94074991
44Steatorrhea (HP:0002570)2.89573707
45Acanthocytosis (HP:0001927)2.82774627
46Metabolic acidosis (HP:0001942)2.81275903
47Myocardial infarction (HP:0001658)2.76004168
48Nephritis (HP:0000123)2.74258198
49Abnormality of purine metabolism (HP:0004352)2.71490711
50Systemic lupus erythematosus (HP:0002725)2.69364239
51Gout (HP:0001997)2.69070666
52Lethargy (HP:0001254)2.63629671
53Dicarboxylic aciduria (HP:0003215)2.62982226
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62982226
55Abnormality of carpal bone ossification (HP:0006257)2.60552638
56Skin nodule (HP:0200036)2.60097184
57Broad alveolar ridges (HP:0000187)2.57755493
58Amyloidosis (HP:0011034)2.57485590
59Small epiphyses (HP:0010585)2.53488028
60Abnormal tarsal ossification (HP:0008369)2.52583928
61Vascular calcification (HP:0004934)2.52486473
62Abnormal gallbladder morphology (HP:0012437)2.50741394
63Glomerulonephritis (HP:0000099)2.49962351
64Increased serum pyruvate (HP:0003542)2.48344470
65Hypoglycemic seizures (HP:0002173)2.48323297
66Cerebral edema (HP:0002181)2.47897634
67Cholelithiasis (HP:0001081)2.46713995
68Pancreatic islet-cell hyperplasia (HP:0004510)2.44360320
69Spastic diplegia (HP:0001264)2.42525883
70Gingival bleeding (HP:0000225)2.39319568
71Irritability (HP:0000737)2.37477686
72Abnormal gallbladder physiology (HP:0012438)2.35052146
73Cholecystitis (HP:0001082)2.35052146
74Neonatal onset (HP:0003623)2.34177827
75Osteomalacia (HP:0002749)2.33361217
76Recurrent gram-negative bacterial infections (HP:0005420)2.30502043
77Poikilocytosis (HP:0004447)2.30192354
78Mitral stenosis (HP:0001718)2.26807441
79Thrombophlebitis (HP:0004418)2.25472401
80Menorrhagia (HP:0000132)2.24275083
81Cardiovascular calcification (HP:0011915)2.23314826
82Enlarged kidneys (HP:0000105)2.22500743
83Vaginal fistula (HP:0004320)2.21783230
84Abnormality of glycolysis (HP:0004366)2.21436216
85Esophageal varix (HP:0002040)2.20242761
86Malnutrition (HP:0004395)2.20079398
87Pancreatitis (HP:0001733)2.17853558
88Generalized aminoaciduria (HP:0002909)2.17585029
89Facial shape deformation (HP:0011334)2.17485483
90Potter facies (HP:0002009)2.17485483
91Pulmonary embolism (HP:0002204)2.15547798
92Arthropathy (HP:0003040)2.13315975
93Vomiting (HP:0002013)2.13003032
94Sensorimotor neuropathy (HP:0007141)2.07504502
95Brushfield spots (HP:0001088)2.06108246
96Abnormality of the gallbladder (HP:0005264)2.03721419
97Hepatoblastoma (HP:0002884)2.02969535
98Late onset (HP:0003584)2.01968167
99Abnormality of iron homeostasis (HP:0011031)2.00648802
100Hyperinsulinemic hypoglycemia (HP:0000825)2.00215632
101Rickets (HP:0002748)1.99240826
102Hemorrhage of the eye (HP:0011885)1.99153565
103Abnormality of transition element cation homeostasis (HP:0011030)1.98991781
104Opisthotonus (HP:0002179)1.93710158
105Confusion (HP:0001289)1.93247266
106Alkalosis (HP:0001948)1.91705918
107Abnormality of the nasal septum (HP:0000419)1.91625701
108Abnormality of proline metabolism (HP:0010907)1.91008081
109Hydroxyprolinuria (HP:0003080)1.91008081
110Broad palm (HP:0001169)1.90533005
111Flat acetabular roof (HP:0003180)1.90140485
112Abnormal hand bone ossification (HP:0010660)1.89921010
113Proximal tubulopathy (HP:0000114)1.88929425
114Abnormal cartilage morphology (HP:0002763)1.88830534
115Pigmentary retinal degeneration (HP:0001146)1.87567883
116Epistaxis (HP:0000421)1.87301909
117Hypophosphatemic rickets (HP:0004912)1.86881442
118Abnormality of the lumbar spine (HP:0100712)1.85054417
119Reticulocytosis (HP:0001923)1.83931996
120Abnormal ossification of hand bones (HP:0005921)1.83055448
121Diastasis recti (HP:0001540)1.82824489
122Abnormal enzyme/coenzyme activity (HP:0012379)1.81315828
123Increased purine levels (HP:0004368)1.80324580
124Hyperuricemia (HP:0002149)1.80324580
125Widely patent fontanelles and sutures (HP:0004492)1.79789264
126Elevated hepatic transaminases (HP:0002910)1.79264595
127Abnormality of the Achilles tendon (HP:0005109)1.75365543
128Increased serum ferritin (HP:0003281)1.75107192
129Alacrima (HP:0000522)1.67768878
130Epiphyseal dysplasia (HP:0002656)1.67586400
131Joint swelling (HP:0001386)1.67369491
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66868827
133Bifid scrotum (HP:0000048)1.66867441
134Gangrene (HP:0100758)1.66786089
135Neoplasm of the liver (HP:0002896)1.61770672
136Asymmetry of the thorax (HP:0001555)1.60595503
137Abnormal delivery (HP:0001787)1.57281396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.64422679
2FGFR44.66308351
3ERN14.32402199
4SIK14.22836230
5WNK44.07444764
6TAOK32.85723038
7INSRR2.85569918
8ERBB42.80130937
9TYRO32.52826154
10CDK122.46433438
11PIK3CA2.27371329
12PKN22.23662044
13MST1R2.20133652
14MAP2K42.18385029
15FGFR12.13258504
16MAPK112.09669897
17TRIB31.95056656
18FLT31.92325987
19TYK21.79220138
20DAPK21.67792551
21PIK3CG1.66047618
22SIK21.62055370
23AKT31.59845661
24PTK61.54225605
25PDGFRA1.54123005
26ABL21.53686285
27KDR1.51413269
28LATS11.50005859
29NEK91.42297260
30GRK61.39923474
31WNK11.38692397
32PDK21.38142408
33BRSK21.36263727
34JAK21.24731745
35MAP2K31.21556084
36PINK11.16594576
37CDK71.14213734
38MAP3K111.09683183
39PRKAA21.09655956
40MAP3K101.08706111
41FRK1.06154680
42FGFR21.05077455
43ERBB21.04417630
44MAP3K31.04413409
45MAP3K21.02084443
46STK38L1.00702921
47MAP3K71.00391902
48MET0.97463825
49NEK20.97239246
50TBK10.96509535
51DDR20.95840574
52BRSK10.95774071
53MATK0.95170864
54EEF2K0.95151406
55MAPK40.93897241
56RPS6KB10.91995077
57TIE10.90532575
58EPHB10.90399564
59JAK10.87970346
60PRKCZ0.85915806
61FGR0.85329060
62MAPK120.81536229
63PRKACG0.80506667
64NTRK30.79815984
65CSNK1E0.77599561
66CDK60.76759253
67DYRK1B0.76492418
68MAP3K140.71919628
69EPHA30.70673751
70PTK20.70005088
71SGK10.69077767
72GSK3A0.69014759
73TGFBR20.68869971
74CAMK2G0.67997973
75PRKAA10.65794406
76MAPK150.65376336
77TAOK20.62496640
78CSK0.62321130
79CDK80.61544332
80MAP2K60.61421330
81CSNK2A20.58649800
82NLK0.57364352
83RIPK10.56653503
84PBK0.54968279
85SGK30.54419754
86MUSK0.54148719
87PDPK10.54075039
88CSNK2A10.52660152
89MAPKAPK30.51687170
90IRAK30.51501106
91CDK40.50747620
92CSF1R0.50153962
93GRK10.48592192
94MAP2K10.46529330
95CSNK1D0.46029090
96NME10.45446918
97MAPK70.45318285
98BCR0.45048945
99IKBKE0.44376723
100PRKCQ0.44319551
101WNK30.44172361
102EIF2AK30.44086641
103PRKCG0.43068802
104MAP3K50.42791583
105CAMK1D0.41855661
106CSNK1G10.41118668
107NEK10.39473934
108FGFR30.37869385
109IGF1R0.37363988
110MTOR0.36720071
111SMG10.36397794
112EIF2AK10.36013171
113SRC0.35929456
114SGK20.35468732
115PRKG10.35110902
116EPHA40.34978780
117SGK4940.34730880
118SGK2230.34730880
119RPS6KA30.34508731
120PDK10.33280619
121TRPM70.32731233
122STK160.32456731
123MAP3K60.32425341
124CDC42BPA0.32377904
125EGFR0.32194539
126STK390.31761406
127MAPK30.31310784
128KSR20.31063242
129LATS20.31053934
130RET0.30837628
131PKN10.30543289
132MAP3K10.29914759
133EPHA20.29184057
134MAP2K20.27821097
135TTK0.27735048
136CAMK40.27638810
137ICK0.27522629
138PRKCA0.26168707
139MAP3K130.25137225
140ITK0.24430886
141CDK10.24245906
142PRKCB0.24144427
143PAK30.24014722
144PRKACA0.22401153
145MAP4K10.21804296
146PDK30.20679037
147PDK40.20679037
148PRKACB0.20381511
149CSNK1G30.18728025
150BMX0.18685262

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39605265
2Nitrogen metabolism_Homo sapiens_hsa009103.65492564
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40595780
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27130450
5Arginine biosynthesis_Homo sapiens_hsa002203.10753422
6Complement and coagulation cascades_Homo sapiens_hsa046102.88773611
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73591257
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.66482778
9Tryptophan metabolism_Homo sapiens_hsa003802.63665139
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59990744
11Fatty acid degradation_Homo sapiens_hsa000712.48736110
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37865620
13Butanoate metabolism_Homo sapiens_hsa006502.18335759
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16753884
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06917120
16Peroxisome_Homo sapiens_hsa041462.05979248
17Propanoate metabolism_Homo sapiens_hsa006401.92384777
18Chemical carcinogenesis_Homo sapiens_hsa052041.89315517
19Histidine metabolism_Homo sapiens_hsa003401.87146015
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85692874
21PPAR signaling pathway_Homo sapiens_hsa033201.85223561
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.80804192
23Fatty acid metabolism_Homo sapiens_hsa012121.79586641
24Staphylococcus aureus infection_Homo sapiens_hsa051501.78500974
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74977237
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72442442
27beta-Alanine metabolism_Homo sapiens_hsa004101.69607026
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.66900708
29Selenocompound metabolism_Homo sapiens_hsa004501.61972528
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60451672
31Caffeine metabolism_Homo sapiens_hsa002321.60345966
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59057109
33Retinol metabolism_Homo sapiens_hsa008301.57428660
34Phenylalanine metabolism_Homo sapiens_hsa003601.56151291
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50389788
36Bile secretion_Homo sapiens_hsa049761.43077421
37Tyrosine metabolism_Homo sapiens_hsa003501.39995579
38Pyruvate metabolism_Homo sapiens_hsa006201.38752430
39Sulfur metabolism_Homo sapiens_hsa009201.37025176
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.37018238
41Fatty acid elongation_Homo sapiens_hsa000621.33988293
42Steroid biosynthesis_Homo sapiens_hsa001001.30923711
43Other glycan degradation_Homo sapiens_hsa005111.28703125
44Biosynthesis of amino acids_Homo sapiens_hsa012301.27460419
45Folate biosynthesis_Homo sapiens_hsa007901.25928717
46Fat digestion and absorption_Homo sapiens_hsa049751.25597472
47Starch and sucrose metabolism_Homo sapiens_hsa005001.22374208
48Carbon metabolism_Homo sapiens_hsa012001.18317958
49ABC transporters_Homo sapiens_hsa020101.12926338
50Vitamin B6 metabolism_Homo sapiens_hsa007501.10861319
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10057611
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.09774055
53Arginine and proline metabolism_Homo sapiens_hsa003301.03757353
54Sulfur relay system_Homo sapiens_hsa041221.02523682
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02479450
56Vitamin digestion and absorption_Homo sapiens_hsa049771.02443239
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.99949375
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87755975
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86356819
60One carbon pool by folate_Homo sapiens_hsa006700.83528961
61Lysine degradation_Homo sapiens_hsa003100.80922251
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73606636
63Glutathione metabolism_Homo sapiens_hsa004800.72977385
64Glycerolipid metabolism_Homo sapiens_hsa005610.66381533
65Pentose phosphate pathway_Homo sapiens_hsa000300.64712747
66N-Glycan biosynthesis_Homo sapiens_hsa005100.57150947
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53283061
68Metabolic pathways_Homo sapiens_hsa011000.48086914
69Pertussis_Homo sapiens_hsa051330.45928984
70Fatty acid biosynthesis_Homo sapiens_hsa000610.45246774
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37045896
72Galactose metabolism_Homo sapiens_hsa000520.31531889
73Prion diseases_Homo sapiens_hsa050200.31221772
74Fructose and mannose metabolism_Homo sapiens_hsa000510.29565533
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27755916
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26216572
77Linoleic acid metabolism_Homo sapiens_hsa005910.24356480
78Insulin resistance_Homo sapiens_hsa049310.20646510
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20553495
80Sphingolipid metabolism_Homo sapiens_hsa006000.19694572
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.18371052
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.15893993
83Glucagon signaling pathway_Homo sapiens_hsa049220.08003645
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00996656
85AMPK signaling pathway_Homo sapiens_hsa041520.00486930
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00252986
87Mineral absorption_Homo sapiens_hsa04978-0.2590277
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2582568
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2289231
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2281948
91Bladder cancer_Homo sapiens_hsa05219-0.2230290
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1867600
93Hepatitis C_Homo sapiens_hsa05160-0.1808432
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1755721
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1741546
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1713147
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1554076
98Regulation of autophagy_Homo sapiens_hsa04140-0.1492153
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1464549
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1400831
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1392725
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1353987
103HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1308535
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1296005
105African trypanosomiasis_Homo sapiens_hsa05143-0.1272999
106Insulin signaling pathway_Homo sapiens_hsa04910-0.1236253
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0867826
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0721437
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0258390

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