APOO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.76190321
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.20480251
3ATP synthesis coupled proton transport (GO:0015986)8.20480251
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.55131978
5respiratory electron transport chain (GO:0022904)6.93567122
6electron transport chain (GO:0022900)6.76354271
7oxidative phosphorylation (GO:0006119)5.34401341
8tricarboxylic acid cycle (GO:0006099)5.15262073
9protein complex biogenesis (GO:0070271)4.91412670
10chaperone-mediated protein transport (GO:0072321)4.90181590
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.77956045
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.77956045
13NADH dehydrogenase complex assembly (GO:0010257)4.77956045
14ATP biosynthetic process (GO:0006754)4.64075435
15mitochondrial respiratory chain complex assembly (GO:0033108)4.46827123
16chromatin remodeling at centromere (GO:0031055)4.42849188
17regulation of acyl-CoA biosynthetic process (GO:0050812)4.35980520
18NADH metabolic process (GO:0006734)4.35830212
19CENP-A containing nucleosome assembly (GO:0034080)4.34354245
20purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.25965921
21purine nucleoside triphosphate biosynthetic process (GO:0009145)4.21498320
22hydrogen ion transmembrane transport (GO:1902600)4.20370526
23protein neddylation (GO:0045116)4.15674487
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.11543937
25regulation of cofactor metabolic process (GO:0051193)4.10286782
26regulation of coenzyme metabolic process (GO:0051196)4.10286782
27inner mitochondrial membrane organization (GO:0007007)4.06282797
28regulation of mitochondrial translation (GO:0070129)3.98780742
29cullin deneddylation (GO:0010388)3.93010340
30histone exchange (GO:0043486)3.82124045
31succinate metabolic process (GO:0006105)3.72772666
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.70885910
33protein deneddylation (GO:0000338)3.70156560
34ribonucleoside triphosphate biosynthetic process (GO:0009201)3.69630777
35aerobic respiration (GO:0009060)3.68425553
36proton transport (GO:0015992)3.67898397
37hydrogen transport (GO:0006818)3.62684776
38ATP hydrolysis coupled proton transport (GO:0015991)3.54779253
39energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.54779253
40kinetochore assembly (GO:0051382)3.53291143
41regulation of oxidative phosphorylation (GO:0002082)3.53258715
42quinone biosynthetic process (GO:1901663)3.51199005
43ubiquinone biosynthetic process (GO:0006744)3.51199005
44dopamine transport (GO:0015872)3.46632155
45kinetochore organization (GO:0051383)3.41633896
46DNA double-strand break processing (GO:0000729)3.37057304
47DNA replication-independent nucleosome assembly (GO:0006336)3.36581226
48DNA replication-independent nucleosome organization (GO:0034724)3.36581226
49resolution of meiotic recombination intermediates (GO:0000712)3.35264316
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.29869458
51nucleoside triphosphate biosynthetic process (GO:0009142)3.29547672
52establishment of integrated proviral latency (GO:0075713)3.27232884
53ubiquinone metabolic process (GO:0006743)3.24617903
54protein localization to kinetochore (GO:0034501)3.23315255
55DNA replication checkpoint (GO:0000076)3.21760165
56positive regulation of mitochondrial fission (GO:0090141)3.18448919
57regulation of sulfur metabolic process (GO:0042762)3.17643497
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14379894
59regulation of cellular respiration (GO:0043457)3.14338709
60heart contraction (GO:0060047)3.13378806
61heart process (GO:0003015)3.13378806
62respiratory chain complex IV assembly (GO:0008535)3.11303556
63protein-cofactor linkage (GO:0018065)3.09363099
64synapsis (GO:0007129)3.09158114
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08711069
66purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07798889
67purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07798889
68termination of RNA polymerase III transcription (GO:0006386)3.06485125
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.06485125
70mitochondrial transport (GO:0006839)3.05533138
71cellular respiration (GO:0045333)3.05376950
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01478135
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01298222
74regulation of cell communication by electrical coupling (GO:0010649)3.00337210
75telomere maintenance via semi-conservative replication (GO:0032201)2.99942460
76cytochrome complex assembly (GO:0017004)2.99713735
77protein targeting to mitochondrion (GO:0006626)2.97433811
78intraciliary transport (GO:0042073)2.92752179
79GTP biosynthetic process (GO:0006183)2.92582624
80DNA ligation (GO:0006266)2.92508349
81generation of precursor metabolites and energy (GO:0006091)2.92305502
82mitotic metaphase plate congression (GO:0007080)2.92055941
83neuron cell-cell adhesion (GO:0007158)2.89998170
84DNA damage response, detection of DNA damage (GO:0042769)2.89996712
85establishment of protein localization to mitochondrion (GO:0072655)2.89643785
86regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.87546786
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87145296
88negative regulation of ligase activity (GO:0051352)2.87145296
89regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86834884
90protein localization to mitochondrion (GO:0070585)2.85273459
91metaphase plate congression (GO:0051310)2.84625124
92histone H2A acetylation (GO:0043968)2.83464797
93detection of calcium ion (GO:0005513)2.83207722
94protein K6-linked ubiquitination (GO:0085020)2.80502417
95purine nucleobase biosynthetic process (GO:0009113)2.79999854
96DNA strand elongation involved in DNA replication (GO:0006271)2.79940251
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79665662
98oxaloacetate metabolic process (GO:0006107)2.77163302
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76422131
100sarcomere organization (GO:0045214)2.74072089
101water-soluble vitamin biosynthetic process (GO:0042364)2.72169247
102negative regulation of DNA-dependent DNA replication (GO:2000104)2.71206275
103sarcoplasmic reticulum calcium ion transport (GO:0070296)2.70842836
104replication fork processing (GO:0031297)2.69015005
105regulation of relaxation of muscle (GO:1901077)2.68779938
106actin-myosin filament sliding (GO:0033275)2.68064420
107muscle filament sliding (GO:0030049)2.68064420
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66916257
109regulation of mitotic spindle checkpoint (GO:1903504)2.66916257
110guanosine-containing compound biosynthetic process (GO:1901070)2.66277271
111DNA catabolic process, exonucleolytic (GO:0000738)2.65535346
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.65216051
113DNA strand elongation (GO:0022616)2.64461323
114positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62827289
115negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62622320
116DNA replication-dependent nucleosome assembly (GO:0006335)2.62302273
117DNA replication-dependent nucleosome organization (GO:0034723)2.62302273
118regulation of cellular amino acid metabolic process (GO:0006521)2.61664692
119purine nucleoside biosynthetic process (GO:0042451)2.61010762
120purine ribonucleoside biosynthetic process (GO:0046129)2.61010762
121synaptic vesicle exocytosis (GO:0016079)2.60770345
122proteasome assembly (GO:0043248)2.59843054
123regulation of meiosis I (GO:0060631)2.58883330
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.58324643
125mitotic recombination (GO:0006312)2.57927470
126transferrin transport (GO:0033572)2.57494411
127protein localization to chromosome, centromeric region (GO:0071459)2.54423812
128double-strand break repair via nonhomologous end joining (GO:0006303)2.54383976
129non-recombinational repair (GO:0000726)2.54383976
130neuronal action potential propagation (GO:0019227)2.52489294
131positive regulation of ligase activity (GO:0051351)2.51680490
132striatum development (GO:0021756)2.51573283
133telomere maintenance via recombination (GO:0000722)2.50848712
134L-serine metabolic process (GO:0006563)2.50564022
135spindle checkpoint (GO:0031577)2.50468829
136calcium-mediated signaling using intracellular calcium source (GO:0035584)2.49951466
137centriole replication (GO:0007099)2.49780688
138quinone metabolic process (GO:1901661)2.49656924
139attachment of spindle microtubules to kinetochore (GO:0008608)2.49350427
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49113585
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49113585
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49113585
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.49113585
144negative regulation of sister chromatid segregation (GO:0033046)2.49113585
145establishment of viral latency (GO:0019043)2.48646575
146ribonucleoside monophosphate biosynthetic process (GO:0009156)2.48603318
147spliceosomal snRNP assembly (GO:0000387)2.48339212
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47506240
149intracellular protein transmembrane import (GO:0044743)2.47370619
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46726501
151regulation of catecholamine metabolic process (GO:0042069)2.46304975
152regulation of dopamine metabolic process (GO:0042053)2.46304975
153cardiac muscle contraction (GO:0060048)2.46285479
154signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45740469
155signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45740469
156signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45740469
157negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.44418501
158presynaptic membrane assembly (GO:0097105)2.44251451
159regulation of ubiquitin-protein transferase activity (GO:0051438)2.42382505
160mitotic spindle checkpoint (GO:0071174)2.41859330
161cellular ketone body metabolic process (GO:0046950)2.40207651
162trivalent inorganic cation transport (GO:0072512)2.40076116
163ferric iron transport (GO:0015682)2.40076116
164iron-sulfur cluster assembly (GO:0016226)2.39874127
165metallo-sulfur cluster assembly (GO:0031163)2.39874127
166negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.39846989
167substantia nigra development (GO:0021762)2.39619579
168regulation of mitochondrial fission (GO:0090140)2.37120039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91277903
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73093705
3E2F7_22180533_ChIP-Seq_HELA_Human3.18351631
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01142329
5GBX2_23144817_ChIP-Seq_PC3_Human2.91623001
6VDR_22108803_ChIP-Seq_LS180_Human2.84909239
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.83235443
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79518598
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.72773861
10TAF15_26573619_Chip-Seq_HEK293_Human2.67435780
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.53861894
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49617249
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28345675
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27516110
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18560144
16FUS_26573619_Chip-Seq_HEK293_Human2.13807797
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10914722
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08230830
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07498004
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04767835
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.94671420
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.92610343
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92527147
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89754242
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88616198
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.87199040
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87114482
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84758195
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82956851
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82645400
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.80660444
32FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.71436723
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69424693
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69409738
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69256624
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67912169
37FOXP3_21729870_ChIP-Seq_TREG_Human1.66088505
38MYC_18940864_ChIP-ChIP_HL60_Human1.64884587
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63253945
40ZNF274_21170338_ChIP-Seq_K562_Hela1.60203120
41P300_19829295_ChIP-Seq_ESCs_Human1.58734870
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56198173
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55613681
44IGF1R_20145208_ChIP-Seq_DFB_Human1.54254040
45TTF2_22483619_ChIP-Seq_HELA_Human1.49252885
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48531538
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48347160
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47222971
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.46693924
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43900021
51REST_21632747_ChIP-Seq_MESCs_Mouse1.40834423
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40599683
53GABP_19822575_ChIP-Seq_HepG2_Human1.39808805
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38200426
55AR_21909140_ChIP-Seq_LNCAP_Human1.38090042
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34788291
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34714525
58EWS_26573619_Chip-Seq_HEK293_Human1.34343752
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.33650461
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33476213
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33217920
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30755227
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28529106
64SMAD4_21799915_ChIP-Seq_A2780_Human1.28509146
65ER_23166858_ChIP-Seq_MCF-7_Human1.28339781
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.28228393
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.27745077
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27045898
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26585229
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.23712407
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22557860
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22384934
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22092451
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.21824347
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21683106
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21417641
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20196488
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19902636
79DCP1A_22483619_ChIP-Seq_HELA_Human1.19640920
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.18103477
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17585999
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.16993139
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15983180
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.15944334
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15513406
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.14699884
87XRN2_22483619_ChIP-Seq_HELA_Human1.14520966
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13540162
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13446616
90VDR_23849224_ChIP-Seq_CD4+_Human1.11550864
91JUN_21703547_ChIP-Seq_K562_Human1.11366625
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11204728
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11068888
94REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10895738
95ELK1_19687146_ChIP-ChIP_HELA_Human1.09734772
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.09451442
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08938133
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08474596
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07054591
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.06657867
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05843988
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05443366
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.05356737
104HTT_18923047_ChIP-ChIP_STHdh_Human1.05170007
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04872167
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04477197
107* RNF2_27304074_Chip-Seq_NSC_Mouse1.03892910
108IRF1_19129219_ChIP-ChIP_H3396_Human1.03849552
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03549374
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00985788
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00067474
112RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99965883
113EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99965883
114* TP53_22573176_ChIP-Seq_HFKS_Human0.99692842
115MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98158613
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97754186
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96581246
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95633456
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95339502
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95204278
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94539854
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94330582
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94256264
124* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94056122
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92976742
126AR_25329375_ChIP-Seq_VCAP_Human0.92892773
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92636823
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91421371
129BCAT_22108803_ChIP-Seq_LS180_Human0.90858556
130SOX9_26525672_Chip-Seq_HEART_Mouse0.90749436
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90031380
132SOX2_19829295_ChIP-Seq_ESCs_Human0.89981868
133NANOG_19829295_ChIP-Seq_ESCs_Human0.89981868
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89451701
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88376612
136* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86586756
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84844863
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82666458
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82661347
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.81472637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.34258283
2MP0003880_abnormal_central_pattern3.96959309
3MP0003646_muscle_fatigue3.51925941
4MP0001529_abnormal_vocalization3.13075207
5MP0004215_abnormal_myocardial_fiber2.93200988
6MP0006292_abnormal_olfactory_placode2.82865376
7MP0008058_abnormal_DNA_repair2.81377530
8MP0000751_myopathy2.62195595
9MP0006036_abnormal_mitochondrial_physio2.51263338
10MP0010094_abnormal_chromosome_stability2.50863017
11MP0000749_muscle_degeneration2.47569980
12MP0004084_abnormal_cardiac_muscle2.44562728
13MP0006276_abnormal_autonomic_nervous2.43199022
14MP0004036_abnormal_muscle_relaxation2.37817064
15MP0004145_abnormal_muscle_electrophysio2.27423001
16MP0002736_abnormal_nociception_after2.26673395
17MP0001905_abnormal_dopamine_level2.14686993
18MP0002938_white_spotting2.11575914
19MP0001968_abnormal_touch/_nociception2.11556577
20MP0003693_abnormal_embryo_hatching2.10470489
21MP0006035_abnormal_mitochondrial_morpho2.00620473
22MP0004270_analgesia1.97010013
23MP0003635_abnormal_synaptic_transmissio1.95963840
24MP0004859_abnormal_synaptic_plasticity1.94149651
25MP0003890_abnormal_embryonic-extraembry1.92171878
26MP0009745_abnormal_behavioral_response1.90373313
27MP0010030_abnormal_orbit_morphology1.88988134
28MP0009046_muscle_twitch1.87327358
29MP0004957_abnormal_blastocyst_morpholog1.81513784
30MP0002734_abnormal_mechanical_nocicepti1.80602959
31MP0001293_anophthalmia1.78530200
32MP0002735_abnormal_chemical_nociception1.77971419
33MP0008789_abnormal_olfactory_epithelium1.77785516
34MP0004484_altered_response_of1.75313974
35MP0002272_abnormal_nervous_system1.72650001
36MP0005330_cardiomyopathy1.71787228
37MP0002102_abnormal_ear_morphology1.71224932
38MP0002063_abnormal_learning/memory/cond1.69833338
39MP0002572_abnormal_emotion/affect_behav1.67483123
40MP0002064_seizures1.65902083
41MP0003137_abnormal_impulse_conducting1.65676760
42MP0004133_heterotaxia1.63357668
43MP0000566_synostosis1.62483964
44MP0001984_abnormal_olfaction1.58850347
45MP0002972_abnormal_cardiac_muscle1.58608109
46MP0001440_abnormal_grooming_behavior1.58222543
47MP0005620_abnormal_muscle_contractility1.57878750
48MP0003186_abnormal_redox_activity1.57069489
49MP0008932_abnormal_embryonic_tissue1.56767044
50MP0003122_maternal_imprinting1.56400828
51MP0005386_behavior/neurological_phenoty1.53767615
52MP0004924_abnormal_behavior1.53767615
53MP0004085_abnormal_heartbeat1.51911318
54MP0004043_abnormal_pH_regulation1.51873825
55MP0002638_abnormal_pupillary_reflex1.50875263
56MP0002067_abnormal_sensory_capabilities1.50445874
57MP0008057_abnormal_DNA_replication1.46705454
58MP0005646_abnormal_pituitary_gland1.46174012
59MP0005499_abnormal_olfactory_system1.44362385
60MP0005394_taste/olfaction_phenotype1.44362385
61MP0003077_abnormal_cell_cycle1.41347359
62MP0004142_abnormal_muscle_tone1.40249010
63MP0002106_abnormal_muscle_physiology1.40087154
64MP0003111_abnormal_nucleus_morphology1.39834063
65MP0001486_abnormal_startle_reflex1.34876772
66MP0002876_abnormal_thyroid_physiology1.33444313
67MP0005253_abnormal_eye_physiology1.32413032
68MP0002822_catalepsy1.30934689
69MP0002210_abnormal_sex_determination1.28736135
70MP0003937_abnormal_limbs/digits/tail_de1.27668860
71MP0001501_abnormal_sleep_pattern1.26084222
72MP0001188_hyperpigmentation1.25733278
73MP0001970_abnormal_pain_threshold1.23739880
74MP0002233_abnormal_nose_morphology1.23179675
75MP0003123_paternal_imprinting1.22009255
76MP0002184_abnormal_innervation1.20847742
77MP0002234_abnormal_pharynx_morphology1.19701333
78MP0005369_muscle_phenotype1.19140497
79MP0002269_muscular_atrophy1.19139184
80MP0010386_abnormal_urinary_bladder1.18716335
81MP0000750_abnormal_muscle_regeneration1.18397067
82MP0008775_abnormal_heart_ventricle1.16895409
83MP0003011_delayed_dark_adaptation1.16382402
84MP0001986_abnormal_taste_sensitivity1.16106129
85MP0002127_abnormal_cardiovascular_syste1.14868101
86MP0004233_abnormal_muscle_weight1.13190865
87MP0003119_abnormal_digestive_system1.13182067
88MP0000747_muscle_weakness1.13058875
89MP0002733_abnormal_thermal_nociception1.12249149
90MP0002332_abnormal_exercise_endurance1.11870708
91MP0003567_abnormal_fetal_cardiomyocyte1.11086989
92MP0006138_congestive_heart_failure1.10967778
93MP0000013_abnormal_adipose_tissue1.10829095
94MP0000049_abnormal_middle_ear1.10601008
95MP0001929_abnormal_gametogenesis1.09543541
96MP0003786_premature_aging1.09044173
97MP0002653_abnormal_ependyma_morphology1.07770425
98MP0009379_abnormal_foot_pigmentation1.05927738
99MP0000778_abnormal_nervous_system1.05501559
100MP0004087_abnormal_muscle_fiber1.04922244
101MP0001544_abnormal_cardiovascular_syste1.04579666
102MP0005385_cardiovascular_system_phenoty1.04579666
103MP0000653_abnormal_sex_gland1.03267527
104MP0002557_abnormal_social/conspecific_i1.03249061
105MP0006072_abnormal_retinal_apoptosis1.02770389
106MP0009697_abnormal_copulation1.02069698
107MP0005423_abnormal_somatic_nervous1.00725317
108MP0001145_abnormal_male_reproductive1.00605546
109MP0003121_genomic_imprinting0.98123073
110MP0005171_absent_coat_pigmentation0.97690564
111MP0003806_abnormal_nucleotide_metabolis0.97473738
112MP0005535_abnormal_body_temperature0.96856445
113MP0001299_abnormal_eye_distance/0.95334574
114MP0003221_abnormal_cardiomyocyte_apopto0.95280425
115MP0004147_increased_porphyrin_level0.95160032
116MP0005408_hypopigmentation0.93883000
117MP0005248_abnormal_Harderian_gland0.93198404
118MP0000230_abnormal_systemic_arterial0.91241562
119MP0000759_abnormal_skeletal_muscle0.91086838
120MP0005551_abnormal_eye_electrophysiolog0.90860155
121MP0001485_abnormal_pinna_reflex0.89488154
122MP0001286_abnormal_eye_development0.89041785
123MP0002160_abnormal_reproductive_system0.88833410
124MP0003698_abnormal_male_reproductive0.88619656
125MP0002090_abnormal_vision0.87805466
126MP0005391_vision/eye_phenotype0.87525587
127MP0002066_abnormal_motor_capabilities/c0.87372057
128MP0002163_abnormal_gland_morphology0.87093403
129MP0003718_maternal_effect0.85687612
130MP0008877_abnormal_DNA_methylation0.84746784
131MP0000647_abnormal_sebaceous_gland0.84019647
132MP0005084_abnormal_gallbladder_morpholo0.82732256
133MP0002697_abnormal_eye_size0.82308035
134MP0000372_irregular_coat_pigmentation0.80189715
135MP0004885_abnormal_endolymph0.79501399
136MP0001764_abnormal_homeostasis0.78257546
137MP0008872_abnormal_physiological_respon0.77840429
138MP0008007_abnormal_cellular_replicative0.77826190
139MP0005266_abnormal_metabolism0.77690871
140MP0003879_abnormal_hair_cell0.77248683
141MP0003136_yellow_coat_color0.77157419
142MP0003755_abnormal_palate_morphology0.77059882
143MP0003787_abnormal_imprinting0.76741531
144MP0005379_endocrine/exocrine_gland_phen0.76319433
145MP0000631_abnormal_neuroendocrine_gland0.75663336
146MP0003195_calcinosis0.75513486
147MP0001963_abnormal_hearing_physiology0.71632803
148MP0002751_abnormal_autonomic_nervous0.71336671
149MP0002882_abnormal_neuron_morphology0.71034688
150MP0008569_lethality_at_weaning0.70028366

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.85252898
2Abnormal mitochondria in muscle tissue (HP:0008316)6.46347153
3Progressive macrocephaly (HP:0004481)5.82855112
4Acute encephalopathy (HP:0006846)5.81925635
5Mitochondrial inheritance (HP:0001427)5.66602600
6Increased CSF lactate (HP:0002490)5.18166049
7Hepatocellular necrosis (HP:0001404)4.88429051
8Hepatic necrosis (HP:0002605)4.65998822
9Abnormality of glycolysis (HP:0004366)4.48344676
10Increased serum pyruvate (HP:0003542)4.48344676
11Cerebral edema (HP:0002181)4.21230387
12Lactic acidosis (HP:0003128)3.81688700
13Exercise intolerance (HP:0003546)3.76158483
14Increased hepatocellular lipid droplets (HP:0006565)3.74853001
15Pheochromocytoma (HP:0002666)3.71691954
16Neuroendocrine neoplasm (HP:0100634)3.68293070
17Lipid accumulation in hepatocytes (HP:0006561)3.62452702
18Respiratory failure (HP:0002878)3.55882557
19Optic disc pallor (HP:0000543)3.43884224
20Focal motor seizures (HP:0011153)3.41905315
21Increased intramyocellular lipid droplets (HP:0012240)3.40258553
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36616475
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36616475
24Calf muscle hypertrophy (HP:0008981)3.28767484
25Muscle hypertrophy of the lower extremities (HP:0008968)3.26233862
26Increased serum lactate (HP:0002151)3.21492352
27Abnormality of the labia minora (HP:0012880)3.19280910
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.11405433
29Increased muscle lipid content (HP:0009058)3.10133755
30Leukodystrophy (HP:0002415)3.02295808
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98348087
32Abnormality of alanine metabolism (HP:0010916)2.98348087
33Hyperalaninemia (HP:0003348)2.98348087
34Exercise-induced myalgia (HP:0003738)2.97726077
35Exercise-induced muscle cramps (HP:0003710)2.91847936
36Renal Fanconi syndrome (HP:0001994)2.90073151
37Sudden death (HP:0001699)2.88302131
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87113974
39Palpitations (HP:0001962)2.78575246
40Pancreatic fibrosis (HP:0100732)2.70598618
41Myoglobinuria (HP:0002913)2.69028170
42Atonic seizures (HP:0010819)2.67190549
433-Methylglutaconic aciduria (HP:0003535)2.65384064
44Intestinal atresia (HP:0011100)2.62678311
45Pancreatic cysts (HP:0001737)2.61212187
46Septo-optic dysplasia (HP:0100842)2.60552309
47Hyperglycinemia (HP:0002154)2.56163135
48Respiratory difficulties (HP:0002880)2.52802465
49Abnormality of midbrain morphology (HP:0002418)2.52269383
50Molar tooth sign on MRI (HP:0002419)2.52269383
51True hermaphroditism (HP:0010459)2.52068736
52X-linked dominant inheritance (HP:0001423)2.46148118
53Abnormal lung lobation (HP:0002101)2.45521129
54Colon cancer (HP:0003003)2.41280719
55Hyperventilation (HP:0002883)2.38972441
56Abnormality of the calf musculature (HP:0001430)2.38831835
57Lethargy (HP:0001254)2.38280118
58Conjunctival hamartoma (HP:0100780)2.35741234
59CNS demyelination (HP:0007305)2.31903522
60Nephronophthisis (HP:0000090)2.26357627
61Medial flaring of the eyebrow (HP:0010747)2.25479714
62Glycosuria (HP:0003076)2.23367663
63Abnormality of urine glucose concentration (HP:0011016)2.23367663
64Emotional lability (HP:0000712)2.23347112
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.20823479
66Absence seizures (HP:0002121)2.20150666
67Atrial fibrillation (HP:0005110)2.18895897
68Bifid tongue (HP:0010297)2.16775151
69Myokymia (HP:0002411)2.14891663
70Meckel diverticulum (HP:0002245)2.14844226
71Rhabdomyolysis (HP:0003201)2.14198431
72Gait imbalance (HP:0002141)2.13984074
73Volvulus (HP:0002580)2.12993407
74Methylmalonic aciduria (HP:0012120)2.10666875
75Exertional dyspnea (HP:0002875)2.09666201
76Congenital primary aphakia (HP:0007707)2.09528088
77Febrile seizures (HP:0002373)2.09004864
78Absent septum pellucidum (HP:0001331)2.08527344
79Myotonia (HP:0002486)2.08001946
80Abnormality of renal resorption (HP:0011038)2.07303496
81Ragged-red muscle fibers (HP:0003200)2.07071360
82Sclerocornea (HP:0000647)2.07023291
83Neoplasm of the adrenal gland (HP:0100631)2.06481896
84Left ventricular hypertrophy (HP:0001712)2.06277112
85Abnormality of the ileum (HP:0001549)2.06205899
86Nephrogenic diabetes insipidus (HP:0009806)2.06159514
87Epileptic encephalopathy (HP:0200134)2.05625902
88Primary atrial arrhythmia (HP:0001692)2.05483407
89Supraventricular tachycardia (HP:0004755)2.05446705
90Abnormality of chromosome stability (HP:0003220)2.02644338
91Unsteady gait (HP:0002317)2.02398870
92Syncope (HP:0001279)2.01273246
93Dicarboxylic aciduria (HP:0003215)1.99717941
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99717941
95Degeneration of anterior horn cells (HP:0002398)1.99553474
96Abnormality of the anterior horn cell (HP:0006802)1.99553474
97Microvesicular hepatic steatosis (HP:0001414)1.97195576
98Hypothermia (HP:0002045)1.96409323
99Supraventricular arrhythmia (HP:0005115)1.95390706
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95064447
101Ketoacidosis (HP:0001993)1.94997949
102Oligodactyly (hands) (HP:0001180)1.94339767
103Abnormality of serum amino acid levels (HP:0003112)1.93618904
104Supernumerary spleens (HP:0009799)1.91116819
105Reticulocytopenia (HP:0001896)1.90356326
106Methylmalonic acidemia (HP:0002912)1.89991689
107Neoplasm of the peripheral nervous system (HP:0100007)1.88992869
108Chromsome breakage (HP:0040012)1.88551393
109Dialeptic seizures (HP:0011146)1.87618503
110Hypoplastic pelvis (HP:0008839)1.87168574
111Optic nerve hypoplasia (HP:0000609)1.85882638
112Abnormal respiratory motile cilium physiology (HP:0012261)1.85646212
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84389488
114Abnormal ciliary motility (HP:0012262)1.84215187
115Anencephaly (HP:0002323)1.84132186
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.83989413
117Generalized aminoaciduria (HP:0002909)1.82670747
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82066805
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81246699
120Abnormal hair whorl (HP:0010721)1.81017184
121Median cleft lip (HP:0000161)1.80765797
122Visual hallucinations (HP:0002367)1.80387910
123Vomiting (HP:0002013)1.79531713
124Abnormality of glycine metabolism (HP:0010895)1.78620553
125Abnormality of serine family amino acid metabolism (HP:0010894)1.78620553
126Double outlet right ventricle (HP:0001719)1.77724139
127Congenital malformation of the right heart (HP:0011723)1.77724139
128Prolonged QT interval (HP:0001657)1.76943923
129Preaxial hand polydactyly (HP:0001177)1.76268417
130Anxiety (HP:0000739)1.73967659
131Anophthalmia (HP:0000528)1.73512757
132Rimmed vacuoles (HP:0003805)1.73331480
133Gliosis (HP:0002171)1.72762637
134Abnormality of the duodenum (HP:0002246)1.72480133
135Triphalangeal thumb (HP:0001199)1.72043234
136Proximal tubulopathy (HP:0000114)1.70935303
137Male pseudohermaphroditism (HP:0000037)1.70029149
138Abnormality of the preputium (HP:0100587)1.69267373
139Vaginal atresia (HP:0000148)1.69251989
140Genital tract atresia (HP:0001827)1.69147103
141Hyperphosphaturia (HP:0003109)1.69001099
142Ventricular tachycardia (HP:0004756)1.68971335
143Gastrointestinal atresia (HP:0002589)1.68754546
144Progressive external ophthalmoplegia (HP:0000590)1.68300021
145Type I transferrin isoform profile (HP:0003642)1.68274016
146Sloping forehead (HP:0000340)1.68241496
147Abnormality of the septum pellucidum (HP:0007375)1.67756009
148Abnormality of the renal medulla (HP:0100957)1.67101155
149Small intestinal stenosis (HP:0012848)1.66796028
150Duodenal stenosis (HP:0100867)1.66796028
151Poor suck (HP:0002033)1.64296338
152Metabolic acidosis (HP:0001942)1.63573928
153Poor coordination (HP:0002370)1.63509396
154Lipoatrophy (HP:0100578)1.62962621
155Abnormality of fatty-acid metabolism (HP:0004359)1.62712395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.39703361
2MAP3K123.25087716
3NME13.17691273
4OBSCN2.91781709
5MAP2K72.73504650
6MYLK2.57008272
7VRK22.44082135
8TRIM282.42004589
9MAP3K42.39974480
10PDK32.39313885
11PDK42.39313885
12MUSK2.27285169
13CDC72.20892720
14MAP4K22.17564838
15STK162.13350239
16WNK32.10550448
17TTK2.05388966
18EPHA41.99918733
19NUAK11.98571771
20NTRK31.91003605
21ARAF1.86920448
22PBK1.80504893
23BCKDK1.75612288
24PLK21.69377913
25NEK11.66872694
26PHKG21.62615162
27PHKG11.62615162
28MAP2K41.52465027
29MAPK131.51337628
30ACVR1B1.49802824
31GRK71.48131665
32WNK41.47261239
33PLK11.46450759
34OXSR11.41155611
35MKNK11.40384215
36CCNB11.38150685
37AKT31.34929411
38BRAF1.34704811
39PDK21.33749894
40STK38L1.31406214
41PINK11.29193932
42MINK11.28770943
43GRK51.26347890
44PNCK1.20712354
45FRK1.19192848
46MARK11.14176145
47VRK11.14083448
48EIF2AK11.12564194
49CSNK1G11.12359706
50STK391.12202201
51CAMK2A1.12124730
52TNIK1.11037404
53SRPK11.10435687
54BCR1.10020848
55BUB11.09381451
56BMPR21.08330979
57ERBB31.07165986
58STK241.06219178
59GRK11.05493678
60CDK81.00534017
61EIF2AK30.96792644
62CAMK2D0.95582842
63DAPK10.93078241
64ZAK0.92488729
65CAMK2B0.92234605
66CHEK20.88186753
67LIMK10.86088793
68CDK190.84768076
69PLK40.83052783
70DYRK30.82234809
71MST40.81658400
72PIK3CA0.81359432
73STK30.79513581
74TAF10.79258814
75PRKCG0.77214404
76TSSK60.76978873
77ATR0.75074970
78MAP3K60.74668788
79BMPR1B0.73768634
80DYRK20.73352117
81AURKB0.71891238
82PRKCE0.70046966
83WEE10.68525680
84CAMK2G0.68406592
85CSNK1A1L0.68277591
86MAP3K90.65185908
87SIK30.63901823
88SGK4940.62728483
89SGK2230.62728483
90INSRR0.61969176
91PLK30.61294712
92PRKACA0.60767129
93ADRBK10.60761659
94BRSK20.60613399
95ATM0.57135889
96EIF2AK20.56686838
97NEK20.56542371
98ADRBK20.56012510
99NTRK20.54697824
100PTK2B0.54553722
101SGK20.54378305
102LMTK20.53270121
103TTN0.52994447
104KSR10.52225525
105FGFR20.52107570
106NME20.51629403
107ERBB40.51539525
108CDK30.50118197
109MAPK120.48701357
110CAMKK20.48290320
111CSNK2A20.47839481
112AURKA0.47713015
113CSNK2A10.47652118
114TGFBR10.46572769
115CDK50.46564564
116CSNK1G30.45965383
117CSNK1E0.45804807
118CDK180.45407676
119CHEK10.44884162
120CDK140.44491774
121UHMK10.43818054
122PASK0.42416499
123FGFR10.41968227
124DYRK1A0.41175641
125PRKD30.39807396
126TLK10.39307853
127MKNK20.39267395
128BRSK10.38924552
129CSNK1G20.38593218
130PAK30.37041930
131PKN10.36876096
132PRKCI0.36826263
133CSNK1A10.36541060
134MAPKAPK50.36423205
135CDK150.35763921
136PRKDC0.35581127
137ILK0.34381149
138PRKACB0.33660889

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.69037868
2Parkinsons disease_Homo sapiens_hsa050124.97339673
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.09923338
4Alzheimers disease_Homo sapiens_hsa050103.72357379
5Huntingtons disease_Homo sapiens_hsa050163.49314445
6Cardiac muscle contraction_Homo sapiens_hsa042603.11085145
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81707766
8Proteasome_Homo sapiens_hsa030502.76882149
9DNA replication_Homo sapiens_hsa030302.52133970
10Homologous recombination_Homo sapiens_hsa034402.43336087
11Collecting duct acid secretion_Homo sapiens_hsa049662.25701120
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09069699
13Propanoate metabolism_Homo sapiens_hsa006402.07672418
14Nicotine addiction_Homo sapiens_hsa050332.04301961
15Non-homologous end-joining_Homo sapiens_hsa034501.99988906
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95399172
17Pyruvate metabolism_Homo sapiens_hsa006201.91374295
18Protein export_Homo sapiens_hsa030601.87740746
19Fanconi anemia pathway_Homo sapiens_hsa034601.81246604
20Steroid biosynthesis_Homo sapiens_hsa001001.79922359
21Base excision repair_Homo sapiens_hsa034101.73204266
22Folate biosynthesis_Homo sapiens_hsa007901.67004642
23Synaptic vesicle cycle_Homo sapiens_hsa047211.62895720
24RNA polymerase_Homo sapiens_hsa030201.58837677
25Ribosome_Homo sapiens_hsa030101.48106814
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47918673
27Carbon metabolism_Homo sapiens_hsa012001.47105010
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35987910
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35391210
30Vibrio cholerae infection_Homo sapiens_hsa051101.33676949
31Fatty acid elongation_Homo sapiens_hsa000621.31562517
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25943160
33Vitamin B6 metabolism_Homo sapiens_hsa007501.21942778
34Sulfur metabolism_Homo sapiens_hsa009201.20625798
35Butanoate metabolism_Homo sapiens_hsa006501.20460518
36Cell cycle_Homo sapiens_hsa041101.18284040
37One carbon pool by folate_Homo sapiens_hsa006701.17881904
38Taste transduction_Homo sapiens_hsa047421.12886316
39GABAergic synapse_Homo sapiens_hsa047271.10806253
40Serotonergic synapse_Homo sapiens_hsa047261.01712561
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99505783
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97014971
43Morphine addiction_Homo sapiens_hsa050320.96857872
44Amphetamine addiction_Homo sapiens_hsa050310.96420994
45Circadian entrainment_Homo sapiens_hsa047130.95089102
46Dopaminergic synapse_Homo sapiens_hsa047280.89721559
47Long-term potentiation_Homo sapiens_hsa047200.80560857
48Fatty acid metabolism_Homo sapiens_hsa012120.80453290
49Metabolic pathways_Homo sapiens_hsa011000.80388057
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.80140451
51Fatty acid degradation_Homo sapiens_hsa000710.79709907
52Glutamatergic synapse_Homo sapiens_hsa047240.79121938
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78513694
54Calcium signaling pathway_Homo sapiens_hsa040200.77946715
55Dilated cardiomyopathy_Homo sapiens_hsa054140.77458289
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76686661
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76533237
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76228351
59Selenocompound metabolism_Homo sapiens_hsa004500.74114295
60Pyrimidine metabolism_Homo sapiens_hsa002400.73761999
61Tryptophan metabolism_Homo sapiens_hsa003800.73213748
62Purine metabolism_Homo sapiens_hsa002300.72059096
63Fructose and mannose metabolism_Homo sapiens_hsa000510.70281235
64Insulin secretion_Homo sapiens_hsa049110.69460141
65Olfactory transduction_Homo sapiens_hsa047400.68773029
66Biosynthesis of amino acids_Homo sapiens_hsa012300.68383207
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.65117142
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64399880
69Phenylalanine metabolism_Homo sapiens_hsa003600.62860597
70RNA degradation_Homo sapiens_hsa030180.61486022
71Phototransduction_Homo sapiens_hsa047440.61441531
72Peroxisome_Homo sapiens_hsa041460.60791631
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60494553
74Sulfur relay system_Homo sapiens_hsa041220.59979301
75Nitrogen metabolism_Homo sapiens_hsa009100.59657589
76Renin secretion_Homo sapiens_hsa049240.58270130
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57320101
78Tyrosine metabolism_Homo sapiens_hsa003500.54958795
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53037108
80Long-term depression_Homo sapiens_hsa047300.51783522
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51300604
82Circadian rhythm_Homo sapiens_hsa047100.50230723
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49866387
84Caffeine metabolism_Homo sapiens_hsa002320.49728963
85Basal cell carcinoma_Homo sapiens_hsa052170.49145620
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48986270
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47981329
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47239515
89Glucagon signaling pathway_Homo sapiens_hsa049220.46707642
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45568406
91Basal transcription factors_Homo sapiens_hsa030220.45391491
92mRNA surveillance pathway_Homo sapiens_hsa030150.45375472
93Cocaine addiction_Homo sapiens_hsa050300.44784324
94Chemical carcinogenesis_Homo sapiens_hsa052040.43789742
95Salivary secretion_Homo sapiens_hsa049700.42773281
96Hedgehog signaling pathway_Homo sapiens_hsa043400.42719748
97Oxytocin signaling pathway_Homo sapiens_hsa049210.42426920
98Oocyte meiosis_Homo sapiens_hsa041140.41492714
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40673225
100Regulation of autophagy_Homo sapiens_hsa041400.40016168
101Cholinergic synapse_Homo sapiens_hsa047250.38983849
102Nucleotide excision repair_Homo sapiens_hsa034200.38653948
103p53 signaling pathway_Homo sapiens_hsa041150.38186419
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37208017
105Gastric acid secretion_Homo sapiens_hsa049710.37113068
106Arginine and proline metabolism_Homo sapiens_hsa003300.36929698
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36711993
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35967263
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34760273
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34670360
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33794971
112Rheumatoid arthritis_Homo sapiens_hsa053230.32755509
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32420997
114Retinol metabolism_Homo sapiens_hsa008300.31413280
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31151558
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30466992
117beta-Alanine metabolism_Homo sapiens_hsa004100.30183586
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30084497
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29323305
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.28078416
121Wnt signaling pathway_Homo sapiens_hsa043100.27934754
122Hippo signaling pathway_Homo sapiens_hsa043900.27824755
123Glutathione metabolism_Homo sapiens_hsa004800.27482132
124Vitamin digestion and absorption_Homo sapiens_hsa049770.27060166
125Galactose metabolism_Homo sapiens_hsa000520.26600982
126N-Glycan biosynthesis_Homo sapiens_hsa005100.26461552
127Gap junction_Homo sapiens_hsa045400.25231444
128Pancreatic secretion_Homo sapiens_hsa049720.24048321
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22861480
130Mismatch repair_Homo sapiens_hsa034300.22386214
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.22383111
132Spliceosome_Homo sapiens_hsa030400.20599048
133RNA transport_Homo sapiens_hsa030130.19929275
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18022416
135Arachidonic acid metabolism_Homo sapiens_hsa005900.17632916
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15920928

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