APOOL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.16648141
2serotonin metabolic process (GO:0042428)4.25010564
3ribosomal small subunit assembly (GO:0000028)3.99545451
4primary amino compound metabolic process (GO:1901160)3.95291851
5neuronal action potential (GO:0019228)3.84882521
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74331153
7proteasome assembly (GO:0043248)3.67807691
8regulation of mesoderm development (GO:2000380)3.60945340
9water-soluble vitamin biosynthetic process (GO:0042364)3.60767701
10polyketide metabolic process (GO:0030638)3.58213849
11doxorubicin metabolic process (GO:0044598)3.58213849
12daunorubicin metabolic process (GO:0044597)3.58213849
13kynurenine metabolic process (GO:0070189)3.55320086
14protein polyglutamylation (GO:0018095)3.53487910
15indole-containing compound metabolic process (GO:0042430)3.43867095
16response to pheromone (GO:0019236)3.34371502
17indole-containing compound catabolic process (GO:0042436)3.25893057
18indolalkylamine catabolic process (GO:0046218)3.25893057
19tryptophan catabolic process (GO:0006569)3.25893057
20preassembly of GPI anchor in ER membrane (GO:0016254)3.24307988
21cellular ketone body metabolic process (GO:0046950)3.24190889
22L-fucose catabolic process (GO:0042355)3.23195865
23fucose catabolic process (GO:0019317)3.23195865
24L-fucose metabolic process (GO:0042354)3.23195865
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20775494
26regulation of memory T cell differentiation (GO:0043380)3.20050629
27endoderm formation (GO:0001706)3.19664298
28sulfation (GO:0051923)3.19397654
29indolalkylamine metabolic process (GO:0006586)3.18786929
30detection of light stimulus involved in sensory perception (GO:0050962)3.09520956
31detection of light stimulus involved in visual perception (GO:0050908)3.09520956
32kidney morphogenesis (GO:0060993)3.09004054
33regulation of action potential (GO:0098900)3.08800764
34gamma-aminobutyric acid transport (GO:0015812)3.05265062
35negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.03677440
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03466124
37somite development (GO:0061053)3.02744486
38piRNA metabolic process (GO:0034587)3.01335681
39rRNA catabolic process (GO:0016075)2.99161979
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96269762
41sleep (GO:0030431)2.94579516
42telomere maintenance via semi-conservative replication (GO:0032201)2.94000461
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93717093
44ketone body metabolic process (GO:1902224)2.93373722
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90688223
46action potential (GO:0001508)2.90629662
47magnesium ion transport (GO:0015693)2.90053078
48positive regulation of action potential (GO:0045760)2.87642461
49CENP-A containing nucleosome assembly (GO:0034080)2.87488385
50adaptation of signaling pathway (GO:0023058)2.86985481
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86746042
52DNA deamination (GO:0045006)2.85471536
53positive regulation of oligodendrocyte differentiation (GO:0048714)2.84476834
54ribosomal large subunit biogenesis (GO:0042273)2.83837946
55membrane depolarization during action potential (GO:0086010)2.83493064
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81726659
57tryptophan metabolic process (GO:0006568)2.80848866
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79713691
59negative regulation of mast cell activation (GO:0033004)2.79496327
60regulation of cilium movement (GO:0003352)2.79322087
61pharyngeal system development (GO:0060037)2.77322955
62maturation of SSU-rRNA (GO:0030490)2.76864166
63oxidative phosphorylation (GO:0006119)2.76204703
64respiratory chain complex IV assembly (GO:0008535)2.76153378
65platelet dense granule organization (GO:0060155)2.75948729
66telomere maintenance via recombination (GO:0000722)2.75143010
67regulation of RIG-I signaling pathway (GO:0039535)2.73322580
68viral transcription (GO:0019083)2.72548990
69L-methionine salvage (GO:0071267)2.72492127
70L-methionine biosynthetic process (GO:0071265)2.72492127
71amino acid salvage (GO:0043102)2.72492127
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70704169
73positive regulation of defense response to virus by host (GO:0002230)2.70487630
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69488025
75negative regulation of systemic arterial blood pressure (GO:0003085)2.69162885
76prostate gland growth (GO:0060736)2.68620843
77cellular response to ATP (GO:0071318)2.67539230
78multicellular organism reproduction (GO:0032504)2.67057361
79purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.65962982
803-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.65962982
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65602728
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65602728
83positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.65560540
84epithelial cilium movement (GO:0003351)2.65527427
85DNA strand elongation (GO:0022616)2.65091755
86NADH dehydrogenase complex assembly (GO:0010257)2.64875635
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64875635
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.64875635
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64827073
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64827073
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64827073
92translational termination (GO:0006415)2.64675575
93protein-cofactor linkage (GO:0018065)2.64172181
94DNA strand elongation involved in DNA replication (GO:0006271)2.63535792
95chromatin remodeling at centromere (GO:0031055)2.63261220
96regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.62602541
97hindbrain development (GO:0030902)2.62533228
98regulation of cellular amino acid metabolic process (GO:0006521)2.61489349
99aldehyde catabolic process (GO:0046185)2.61294354
100axoneme assembly (GO:0035082)2.60202312
101histone H4-K12 acetylation (GO:0043983)2.59250800
102deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58972544
103aminoglycoside antibiotic metabolic process (GO:0030647)2.58627851
104GPI anchor metabolic process (GO:0006505)2.57180079
105heart contraction (GO:0060047)2.56970601
106heart process (GO:0003015)2.56970601
107reflex (GO:0060004)2.56799369
108ribosomal small subunit biogenesis (GO:0042274)2.56331440
109DNA methylation involved in gamete generation (GO:0043046)2.55638461
110cornea development in camera-type eye (GO:0061303)2.55408024
111S-adenosylmethionine metabolic process (GO:0046500)2.55134783
112aerobic respiration (GO:0009060)2.54081213
113regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53807043
114negative regulation of telomere maintenance (GO:0032205)2.53400285
115protein K6-linked ubiquitination (GO:0085020)2.52797865
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.52066912
117response to interferon-beta (GO:0035456)2.51449835
118regulation of activation of Janus kinase activity (GO:0010533)2.50267455
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50025279
120signal transduction involved in DNA damage checkpoint (GO:0072422)2.49573930
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.49573930
122regulation of germinal center formation (GO:0002634)2.49084805
123positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48318528
124spinal cord motor neuron differentiation (GO:0021522)2.48260783
125signal transduction involved in cell cycle checkpoint (GO:0072395)2.47795443
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47136093
127mannosylation (GO:0097502)2.45741954
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45201482
129positive regulation of mRNA catabolic process (GO:0061014)2.44496765
130behavioral response to ethanol (GO:0048149)2.44279562
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44098298
132RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44098298
133membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43283414
134cytochrome complex assembly (GO:0017004)2.43239679
135iron-sulfur cluster assembly (GO:0016226)2.43034101
136metallo-sulfur cluster assembly (GO:0031163)2.43034101
137rhodopsin mediated signaling pathway (GO:0016056)2.42575523
138branched-chain amino acid catabolic process (GO:0009083)2.42540040
139positive regulation of fatty acid transport (GO:2000193)2.42418807
140somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41909379
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41909379
142isotype switching (GO:0045190)2.41909379
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40651783
144cotranslational protein targeting to membrane (GO:0006613)2.40057360
145regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.39072628
146positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.39072628
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.38941169
148negative regulation of ligase activity (GO:0051352)2.38941169
149synaptic transmission, cholinergic (GO:0007271)2.38935059
150protein complex biogenesis (GO:0070271)2.38512580
151dopamine transport (GO:0015872)2.38244117
152neutrophil activation involved in immune response (GO:0002283)2.38030249
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.37717147
154termination of RNA polymerase III transcription (GO:0006386)2.37717147
155regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37506958
156regulation of mitotic spindle checkpoint (GO:1903504)2.37506958
157mitotic recombination (GO:0006312)2.37448015
158parturition (GO:0007567)2.37078226
159nonmotile primary cilium assembly (GO:0035058)2.36082974
160protein targeting to ER (GO:0045047)2.35771092
161regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.35347510
162antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.34854948
163ubiquinone biosynthetic process (GO:0006744)2.32794804
164quinone biosynthetic process (GO:1901663)2.32794804
165translational elongation (GO:0006414)2.32154534
166anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.31783671
167regulation of metalloenzyme activity (GO:0048552)2.31704852
168rRNA modification (GO:0000154)2.31431388
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.31401771
170kinetochore assembly (GO:0051382)2.29771058
171telomere maintenance via telomere lengthening (GO:0010833)2.28435453
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.28317303
173ATP synthesis coupled proton transport (GO:0015986)2.28317303
174protein localization to endoplasmic reticulum (GO:0070972)2.26466383
175kinetochore organization (GO:0051383)2.25880793
176cellular respiration (GO:0045333)2.24940691
177translation (GO:0006412)2.22255125
178response to interferon-alpha (GO:0035455)2.20899925
179DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.20044631
180establishment of protein localization to endoplasmic reticulum (GO:0072599)2.19594858
181regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.19559792
182mitochondrial respiratory chain complex assembly (GO:0033108)2.18234116
183branched-chain amino acid metabolic process (GO:0009081)2.17164089
184transcription-coupled nucleotide-excision repair (GO:0006283)2.16356784
185positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.16033269
186superoxide anion generation (GO:0042554)2.14742097
187respiratory electron transport chain (GO:0022904)2.14435641
188valine metabolic process (GO:0006573)2.13081961
189meiotic chromosome segregation (GO:0045132)2.12655895
190deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.11388963
191purine ribonucleotide transport (GO:0015868)2.10849003
192DNA replication initiation (GO:0006270)2.10498887
193purine nucleobase biosynthetic process (GO:0009113)2.09870340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.59477638
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78933210
3EZH2_22144423_ChIP-Seq_EOC_Human3.46274759
4VDR_22108803_ChIP-Seq_LS180_Human3.41885683
5ZNF274_21170338_ChIP-Seq_K562_Hela3.27938340
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.21833204
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.09898195
8GBX2_23144817_ChIP-Seq_PC3_Human3.07069362
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04110657
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.99940700
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.99822335
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87744492
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85893520
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84871244
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.81327803
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.66746355
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61095571
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60431137
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59519410
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59503145
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.50528335
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47167959
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45011949
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41808347
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40130597
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38206600
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.35448047
28TAF15_26573619_Chip-Seq_HEK293_Human2.25938590
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23826064
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22272509
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20637941
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18649380
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.17287466
34ELK1_19687146_ChIP-ChIP_HELA_Human2.14215235
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12778631
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11187789
37VDR_23849224_ChIP-Seq_CD4+_Human2.10638790
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10360051
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09047293
40EWS_26573619_Chip-Seq_HEK293_Human2.08530102
41HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05418895
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05158158
43CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03580472
44IGF1R_20145208_ChIP-Seq_DFB_Human2.03226276
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99470381
46P300_19829295_ChIP-Seq_ESCs_Human1.96762489
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95225773
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93569727
49FUS_26573619_Chip-Seq_HEK293_Human1.90336520
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89967514
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89842435
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87527821
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87044915
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86921747
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86811268
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86256868
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82210459
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81239700
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78463650
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77187285
61FOXP3_21729870_ChIP-Seq_TREG_Human1.74001596
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71317110
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70091698
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68484111
65ER_23166858_ChIP-Seq_MCF-7_Human1.65762396
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61435462
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59091412
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54959526
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.54762168
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54000216
71DCP1A_22483619_ChIP-Seq_HELA_Human1.52669085
72SMAD4_21799915_ChIP-Seq_A2780_Human1.51989996
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48543800
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48505928
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48411677
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48021899
77XRN2_22483619_ChIP-Seq_HELA_Human1.45659812
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45409739
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45125892
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44600219
81AR_25329375_ChIP-Seq_VCAP_Human1.44149217
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43658450
83STAT3_23295773_ChIP-Seq_U87_Human1.42967425
84RNF2_27304074_Chip-Seq_NSC_Mouse1.42557795
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.42265504
86SPI1_23547873_ChIP-Seq_NB4_Human1.40829637
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38373294
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.37987056
89AR_21909140_ChIP-Seq_LNCAP_Human1.37760446
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36996429
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36858516
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.36805105
93BCAT_22108803_ChIP-Seq_LS180_Human1.36783734
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36261669
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.36261669
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.36189477
97CBP_20019798_ChIP-Seq_JUKART_Human1.35529697
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35529697
99TCF4_23295773_ChIP-Seq_U87_Human1.33821577
100TP53_22573176_ChIP-Seq_HFKS_Human1.33467646
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.31443200
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31316659
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.31168566
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30809531
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30467339
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30269740
107MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29469924
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28546362
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27786669
110REST_21632747_ChIP-Seq_MESCs_Mouse1.27274496
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.27143430
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26166566
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.25606093
114RUNX2_22187159_ChIP-Seq_PCA_Human1.25076311
115SCL_19346495_ChIP-Seq_HPC-7_Human1.24354138
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.23048106
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22944687
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22473295
119GABP_19822575_ChIP-Seq_HepG2_Human1.22273773
120NANOG_19829295_ChIP-Seq_ESCs_Human1.21802128
121SOX2_19829295_ChIP-Seq_ESCs_Human1.21802128
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21399428
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20964772
124TTF2_22483619_ChIP-Seq_HELA_Human1.20826410
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20399898
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20278676
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.19857691
128TCF4_22108803_ChIP-Seq_LS180_Human1.19026497
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.18891316
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18523163
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18261257
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17881137
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.15629920
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13741258
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.13457922
136PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13260687
137NCOR_22424771_ChIP-Seq_293T_Human1.11824985
138GATA1_22025678_ChIP-Seq_K562_Human1.11817137
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11812222
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10744258
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10340632
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10081064
143RXR_22158963_ChIP-Seq_LIVER_Mouse1.09555931
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.08959862
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08821994
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08133694
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07366198
148P53_22387025_ChIP-Seq_ESCs_Mouse1.05850206
149AR_20517297_ChIP-Seq_VCAP_Human1.05200910
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05121848
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04848719
152ELK1_22589737_ChIP-Seq_MCF10A_Human1.04745149
153PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04665884
154GATA3_21878914_ChIP-Seq_MCF-7_Human1.03957540
155IRF8_27001747_Chip-Seq_BMDM_Mouse1.03370293
156CRX_20693478_ChIP-Seq_RETINA_Mouse1.03302874
157SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02686664
158THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02384599
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02259235
160* TAL1_26923725_Chip-Seq_HPCs_Mouse1.02209719
161AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02052903
162E2F1_21310950_ChIP-Seq_MCF-7_Human1.01541302
163ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00311056
164JUN_21703547_ChIP-Seq_K562_Human0.99488102
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.99278996
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99000029
167AR_21572438_ChIP-Seq_LNCaP_Human0.98792867
168NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98755999
169* HOXB7_26014856_ChIP-Seq_BT474_Human0.98601957
170CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98454764
171STAT3_18555785_Chip-Seq_ESCs_Mouse0.97136104
172ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97067850
173PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96410704
174MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95800219
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93894067
176YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92913669
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91723231
178CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91698654
179GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91454356
180IRF1_19129219_ChIP-ChIP_H3396_Human0.90503995
181RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90241695
182TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89599226
183SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89287275
184MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89150448
185FLI1_27457419_Chip-Seq_LIVER_Mouse0.88004672
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87087366
187KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86475294
188ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85238658
189POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84978067
190MYC_18940864_ChIP-ChIP_HL60_Human0.84355933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.02746282
2MP0004885_abnormal_endolymph2.98545220
3MP0008877_abnormal_DNA_methylation2.85776673
4MP0002837_dystrophic_cardiac_calcinosis2.79045847
5MP0003283_abnormal_digestive_organ2.77950816
6MP0005646_abnormal_pituitary_gland2.51543177
7MP0006072_abnormal_retinal_apoptosis2.46086421
8MP0002277_abnormal_respiratory_mucosa2.43813153
9MP0001968_abnormal_touch/_nociception2.42549581
10MP0001835_abnormal_antigen_presentation2.40169251
11MP0003186_abnormal_redox_activity2.35316408
12MP0002396_abnormal_hematopoietic_system2.33208274
13MP0002876_abnormal_thyroid_physiology2.30429519
14MP0005551_abnormal_eye_electrophysiolog2.24934091
15MP0009785_altered_susceptibility_to2.20688039
16MP0000569_abnormal_digit_pigmentation2.19054506
17MP0000566_synostosis2.15891671
18MP0009697_abnormal_copulation2.12814895
19MP0003693_abnormal_embryo_hatching2.12493483
20MP0002148_abnormal_hypersensitivity_rea2.10418557
21MP0004147_increased_porphyrin_level2.07457760
22MP0005085_abnormal_gallbladder_physiolo2.04438556
23MP0002163_abnormal_gland_morphology2.02247164
24MP0003011_delayed_dark_adaptation2.00601458
25MP0001986_abnormal_taste_sensitivity2.00121311
26MP0009745_abnormal_behavioral_response1.98336995
27MP0002736_abnormal_nociception_after1.96679497
28MP0004145_abnormal_muscle_electrophysio1.90574459
29MP0002272_abnormal_nervous_system1.86189487
30MP0005451_abnormal_body_composition1.81241269
31MP0003724_increased_susceptibility_to1.81092546
32MP0001853_heart_inflammation1.81069839
33MP0008057_abnormal_DNA_replication1.76134986
34MP0005360_urolithiasis1.75952659
35MP0002132_abnormal_respiratory_system1.75371098
36MP0009046_muscle_twitch1.75302242
37MP0005671_abnormal_response_to1.74954110
38MP0010094_abnormal_chromosome_stability1.72570281
39MP0008872_abnormal_physiological_respon1.71789460
40MP0004133_heterotaxia1.68869172
41MP0005253_abnormal_eye_physiology1.66483191
42MP0000685_abnormal_immune_system1.66423022
43MP0002139_abnormal_hepatobiliary_system1.66287956
44MP0005365_abnormal_bile_salt1.62176032
45MP0002735_abnormal_chemical_nociception1.61587103
46MP0003787_abnormal_imprinting1.60582311
47MP0005645_abnormal_hypothalamus_physiol1.60563274
48MP0004142_abnormal_muscle_tone1.57757540
49MP0005025_abnormal_response_to1.56897037
50MP0008058_abnormal_DNA_repair1.56783831
51MP0004381_abnormal_hair_follicle1.53111651
52MP0005389_reproductive_system_phenotype1.53038354
53MP0001501_abnormal_sleep_pattern1.50432732
54MP0000631_abnormal_neuroendocrine_gland1.49619121
55MP0001485_abnormal_pinna_reflex1.48118911
56MP0001486_abnormal_startle_reflex1.46299825
57MP0006036_abnormal_mitochondrial_physio1.45789144
58MP0008007_abnormal_cellular_replicative1.44918145
59MP0002160_abnormal_reproductive_system1.44073974
60MP0003646_muscle_fatigue1.43158918
61MP0005075_abnormal_melanosome_morpholog1.39299026
62MP0002234_abnormal_pharynx_morphology1.38685440
63MP0009379_abnormal_foot_pigmentation1.37174976
64MP0003119_abnormal_digestive_system1.36994052
65MP0000427_abnormal_hair_cycle1.36537780
66MP0003077_abnormal_cell_cycle1.35764259
67MP0002419_abnormal_innate_immunity1.34267986
68MP0003436_decreased_susceptibility_to1.33055770
69MP0002064_seizures1.31250225
70MP0005408_hypopigmentation1.29240364
71MP0001800_abnormal_humoral_immune1.28886080
72MP0002938_white_spotting1.28103354
73MP0004043_abnormal_pH_regulation1.27879148
74MP0003136_yellow_coat_color1.27680988
75MP0003880_abnormal_central_pattern1.27185955
76MP0001764_abnormal_homeostasis1.26608397
77MP0001440_abnormal_grooming_behavior1.26387561
78MP0001346_abnormal_lacrimal_gland1.26272899
79MP0001919_abnormal_reproductive_system1.26010169
80MP0005379_endocrine/exocrine_gland_phen1.25326002
81MP0006082_CNS_inflammation1.24295505
82MP0002452_abnormal_antigen_presenting1.22835271
83MP0002638_abnormal_pupillary_reflex1.22570809
84MP0005000_abnormal_immune_tolerance1.22440535
85MP0009764_decreased_sensitivity_to1.22021190
86MP0004782_abnormal_surfactant_physiolog1.21606857
87MP0002723_abnormal_immune_serum1.21459356
88MP0004742_abnormal_vestibular_system1.20217715
89MP0003567_abnormal_fetal_cardiomyocyte1.19713990
90MP0005387_immune_system_phenotype1.19209933
91MP0001790_abnormal_immune_system1.19209933
92MP0002138_abnormal_hepatobiliary_system1.18662880
93MP0003111_abnormal_nucleus_morphology1.18618462
94MP0004957_abnormal_blastocyst_morpholog1.16069585
95MP0002572_abnormal_emotion/affect_behav1.15698407
96MP0003950_abnormal_plasma_membrane1.10346277
97MP0003828_pulmonary_edema1.10223766
98MP0008469_abnormal_protein_level1.09545732
99MP0001819_abnormal_immune_cell1.09498643
100MP0005386_behavior/neurological_phenoty1.08026080
101MP0004924_abnormal_behavior1.08026080
102MP0000372_irregular_coat_pigmentation1.08025357
103MP0002420_abnormal_adaptive_immunity1.07150044
104MP0003718_maternal_effect1.05287541
105MP0000383_abnormal_hair_follicle1.05224727
106MP0010386_abnormal_urinary_bladder1.05013603
107MP0003763_abnormal_thymus_physiology1.04679445
108MP0002734_abnormal_mechanical_nocicepti1.04504870
109MP0000749_muscle_degeneration1.04401261
110MP0002733_abnormal_thermal_nociception1.04331804
111MP0003656_abnormal_erythrocyte_physiolo1.03459020
112MP0000490_abnormal_crypts_of1.03397565
113MP0005084_abnormal_gallbladder_morpholo1.02934480
114MP0002557_abnormal_social/conspecific_i1.02331479
115MP0006292_abnormal_olfactory_placode1.01974017
116MP0009780_abnormal_chondrocyte_physiolo1.01870135
117MP0003635_abnormal_synaptic_transmissio1.00887616
118MP0001970_abnormal_pain_threshold0.99454091
119MP0004130_abnormal_muscle_cell0.99335026
120MP0005332_abnormal_amino_acid0.96873521
121MP0004084_abnormal_cardiac_muscle0.96081972
122MP0005330_cardiomyopathy0.95422826
123MP0000716_abnormal_immune_system0.94040557
124MP0008995_early_reproductive_senescence0.93863263
125MP0002063_abnormal_learning/memory/cond0.93793934
126MP0002102_abnormal_ear_morphology0.93755773
127MP0002067_abnormal_sensory_capabilities0.93651811
128MP0002398_abnormal_bone_marrow0.92868943
129MP0005187_abnormal_penis_morphology0.92702423
130MP0009333_abnormal_splenocyte_physiolog0.92500591
131MP0008932_abnormal_embryonic_tissue0.91752561
132MP0005670_abnormal_white_adipose0.91078335
133MP0005397_hematopoietic_system_phenotyp0.90000026
134MP0001545_abnormal_hematopoietic_system0.90000026
135MP0003195_calcinosis0.89978074
136MP0009763_increased_sensitivity_to0.88834876
137MP0002429_abnormal_blood_cell0.88488714
138MP0003938_abnormal_ear_development0.88357522
139MP0001765_abnormal_ion_homeostasis0.87908365
140MP0001905_abnormal_dopamine_level0.86581476
141MP0002909_abnormal_adrenal_gland0.86463571
142MP0003638_abnormal_response/metabolism_0.86290074
143MP0002928_abnormal_bile_duct0.86088493
144MP0001963_abnormal_hearing_physiology0.85857693
145MP0006276_abnormal_autonomic_nervous0.85703577
146MP0008875_abnormal_xenobiotic_pharmacok0.85428854
147MP0005319_abnormal_enzyme/_coenzyme0.85343839
148MP0003137_abnormal_impulse_conducting0.84938194
149MP0005464_abnormal_platelet_physiology0.84817898
150MP0008775_abnormal_heart_ventricle0.84411550
151MP0001845_abnormal_inflammatory_respons0.84390749
152MP0000689_abnormal_spleen_morphology0.84025354
153MP0002653_abnormal_ependyma_morphology0.83328481
154MP0000026_abnormal_inner_ear0.82828951
155MP0005195_abnormal_posterior_eye0.82521103
156MP0000230_abnormal_systemic_arterial0.81641304
157MP0002751_abnormal_autonomic_nervous0.81426947
158MP0003221_abnormal_cardiomyocyte_apopto0.80214000
159MP0001293_anophthalmia0.79739193
160MP0002933_joint_inflammation0.79724554
161MP0002722_abnormal_immune_system0.79571889
162MP0002006_tumorigenesis0.78885360
163MP0000343_altered_response_to0.78277697
164MP0003937_abnormal_limbs/digits/tail_de0.77514565
165MP0010155_abnormal_intestine_physiology0.77361125
166MP0003941_abnormal_skin_development0.77185391
167MP0002693_abnormal_pancreas_physiology0.77075745
168MP0002166_altered_tumor_susceptibility0.75635430
169MP0010329_abnormal_lipoprotein_level0.74893522
170MP0004215_abnormal_myocardial_fiber0.74122225
171MP0003191_abnormal_cellular_cholesterol0.73616004
172MP0002184_abnormal_innervation0.73410753
173MP0001324_abnormal_eye_pigmentation0.72702035
174MP0001879_abnormal_lymphatic_vessel0.72253492
175MP0009250_abnormal_appendicular_skeleto0.72076175
176MP0005174_abnormal_tail_pigmentation0.72034082
177MP0002229_neurodegeneration0.71446057
178MP0002752_abnormal_somatic_nervous0.69676468
179MP0004085_abnormal_heartbeat0.69444241
180MP0003879_abnormal_hair_cell0.69100605

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.13377274
2Congenital stationary night blindness (HP:0007642)3.80145980
3Pancreatic fibrosis (HP:0100732)3.73111199
4Lipid accumulation in hepatocytes (HP:0006561)3.57133155
5Hepatic necrosis (HP:0002605)3.54046287
6Nephronophthisis (HP:0000090)3.53938424
7Increased hepatocellular lipid droplets (HP:0006565)3.51512373
8Molar tooth sign on MRI (HP:0002419)3.49491263
9Abnormality of midbrain morphology (HP:0002418)3.49491263
10True hermaphroditism (HP:0010459)3.39750317
11Abnormality of the renal cortex (HP:0011035)3.26287333
12Reticulocytopenia (HP:0001896)3.17926260
13Hepatocellular necrosis (HP:0001404)3.15271202
143-Methylglutaconic aciduria (HP:0003535)3.13912560
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09432215
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09432215
17Generalized aminoaciduria (HP:0002909)3.02559922
18Mitochondrial inheritance (HP:0001427)2.99043684
19Renal Fanconi syndrome (HP:0001994)2.97982251
20Abnormality of the renal medulla (HP:0100957)2.97464602
21Increased intramyocellular lipid droplets (HP:0012240)2.90089166
22Increased muscle lipid content (HP:0009058)2.89054114
23Abnormality of fatty-acid metabolism (HP:0004359)2.88214474
24Increased CSF lactate (HP:0002490)2.85977224
25Nausea (HP:0002018)2.85813098
26Increased serum pyruvate (HP:0003542)2.79460229
27Abnormality of glycolysis (HP:0004366)2.79460229
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.78188671
29Medial flaring of the eyebrow (HP:0010747)2.78133892
30Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78027802
31Dicarboxylic aciduria (HP:0003215)2.78027802
32Hyperventilation (HP:0002883)2.77977209
33Exertional dyspnea (HP:0002875)2.76795825
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73917140
35Renal cortical cysts (HP:0000803)2.73599879
36Type II lissencephaly (HP:0007260)2.72788213
37Abolished electroretinogram (ERG) (HP:0000550)2.66931379
38Reduced antithrombin III activity (HP:0001976)2.66641009
39Increased serum lactate (HP:0002151)2.65435022
40Abnormality of urine glucose concentration (HP:0011016)2.64517237
41Glycosuria (HP:0003076)2.64517237
42Acute necrotizing encephalopathy (HP:0006965)2.57608172
43Parakeratosis (HP:0001036)2.54531780
44Abnormal mitochondria in muscle tissue (HP:0008316)2.53649787
45Chromsome breakage (HP:0040012)2.48878338
46Gaze-evoked nystagmus (HP:0000640)2.48794691
47Clumsiness (HP:0002312)2.48653161
48Large for gestational age (HP:0001520)2.48039682
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47932897
50Acute encephalopathy (HP:0006846)2.44871530
51Inability to walk (HP:0002540)2.41128737
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40610018
53Aplastic anemia (HP:0001915)2.39837325
54Furrowed tongue (HP:0000221)2.39639294
55Stomach cancer (HP:0012126)2.37865077
56Lactic acidosis (HP:0003128)2.37851824
57IgG deficiency (HP:0004315)2.37562594
58Proximal tubulopathy (HP:0000114)2.36612581
59Sclerocornea (HP:0000647)2.35929661
60Hypoglycemic coma (HP:0001325)2.35881905
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35344025
62Cerebral edema (HP:0002181)2.32971848
63Attenuation of retinal blood vessels (HP:0007843)2.31581309
64Type I transferrin isoform profile (HP:0003642)2.31421446
65Congenital sensorineural hearing impairment (HP:0008527)2.31124819
66Abnormality of cells of the erythroid lineage (HP:0012130)2.30795223
67Respiratory difficulties (HP:0002880)2.30645010
68Short tibia (HP:0005736)2.30471037
69Abnormal trabecular bone morphology (HP:0100671)2.30225887
70Pendular nystagmus (HP:0012043)2.29638378
71Cystic liver disease (HP:0006706)2.29035399
72Aplasia/hypoplasia of the uterus (HP:0008684)2.28824827
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28338375
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27201875
75Abnormality of alanine metabolism (HP:0010916)2.27201875
76Hyperalaninemia (HP:0003348)2.27201875
77Broad-based gait (HP:0002136)2.26658005
78Hypoplasia of the uterus (HP:0000013)2.26653675
79Increased corneal curvature (HP:0100692)2.24289454
80Keratoconus (HP:0000563)2.24289454
81Abnormal number of erythroid precursors (HP:0012131)2.22740800
82Tubular atrophy (HP:0000092)2.22262784
83Abnormal respiratory motile cilium morphology (HP:0005938)2.21668310
84Abnormal respiratory epithelium morphology (HP:0012253)2.21668310
85Progressive inability to walk (HP:0002505)2.20405626
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.19725872
87Absent/shortened dynein arms (HP:0200106)2.19725872
88Exercise intolerance (HP:0003546)2.14518528
89Rhabdomyolysis (HP:0003201)2.14137797
90Prolonged neonatal jaundice (HP:0006579)2.13681109
91Patchy hypopigmentation of hair (HP:0011365)2.12289993
92Hyperammonemia (HP:0001987)2.10228042
93Gait imbalance (HP:0002141)2.09063515
94Progressive cerebellar ataxia (HP:0002073)2.08046118
95Methylmalonic acidemia (HP:0002912)2.07314037
96Hypothermia (HP:0002045)2.07054020
97Oral leukoplakia (HP:0002745)2.06796686
98Genetic anticipation (HP:0003743)2.06747568
99Methylmalonic aciduria (HP:0012120)2.06745979
100Microvesicular hepatic steatosis (HP:0001414)2.06185628
101Abnormality of the renal collecting system (HP:0004742)2.06141059
102Abnormality of renal resorption (HP:0011038)2.05423014
103Duplicated collecting system (HP:0000081)2.05374145
104Pancytopenia (HP:0001876)2.05353630
105Lethargy (HP:0001254)2.04954611
106Male pseudohermaphroditism (HP:0000037)2.04807041
107Chorioretinal atrophy (HP:0000533)2.03494116
108Abnormality of serum amino acid levels (HP:0003112)2.02567250
109Aplasia/Hypoplasia of the spleen (HP:0010451)2.02422594
110Congenital primary aphakia (HP:0007707)2.02011454
111Concave nail (HP:0001598)2.01917849
112Abnormality of pyrimidine metabolism (HP:0004353)2.01541421
113Aplasia/Hypoplasia of the hallux (HP:0008362)2.01532163
114Bilateral microphthalmos (HP:0007633)2.00273094
115Abnormality of the proximal phalanges of the hand (HP:0009834)1.98492424
116Asplenia (HP:0001746)1.98488089
117Abnormal rod and cone electroretinograms (HP:0008323)1.98380392
118Decreased central vision (HP:0007663)1.98147284
119Short hallux (HP:0010109)1.96995069
120Congenital, generalized hypertrichosis (HP:0004540)1.96612211
121Febrile seizures (HP:0002373)1.95792109
122Abnormal drinking behavior (HP:0030082)1.95754396
123Polydipsia (HP:0001959)1.95754396
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95175123
125Abnormality of secondary sexual hair (HP:0009888)1.94473086
126Abnormality of the axillary hair (HP:0100134)1.94473086
127Respiratory failure (HP:0002878)1.94130257
128Prostate neoplasm (HP:0100787)1.92606428
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.91262940
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.91123753
131Opisthotonus (HP:0002179)1.90210676
132Hemiparesis (HP:0001269)1.89903821
133Congenital hepatic fibrosis (HP:0002612)1.88831319
134Abnormality of the pons (HP:0007361)1.88557177
135Rough bone trabeculation (HP:0100670)1.87314176
136Macrocytic anemia (HP:0001972)1.87196524
137Protruding tongue (HP:0010808)1.86312723
138Hypoplasia of the pons (HP:0012110)1.85448382
139Neutropenia (HP:0001875)1.85439589
140Sparse eyelashes (HP:0000653)1.84372406
141Hyperglycinemia (HP:0002154)1.83120420
142Progressive macrocephaly (HP:0004481)1.82971839
143Nephrogenic diabetes insipidus (HP:0009806)1.82103051
144White forelock (HP:0002211)1.81464597
145Hypobetalipoproteinemia (HP:0003563)1.81387771
146Decreased circulating renin level (HP:0003351)1.81095738
147Genital tract atresia (HP:0001827)1.80327447
148Recurrent abscess formation (HP:0002722)1.79536660
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.79363214
150Hypoplasia of the fovea (HP:0007750)1.79363214
151Metabolic acidosis (HP:0001942)1.79242820
152Type 2 muscle fiber atrophy (HP:0003554)1.79222045
153Intrahepatic cholestasis (HP:0001406)1.78458446
154Abnormality of the preputium (HP:0100587)1.78432064
155Morphological abnormality of the middle ear (HP:0008609)1.78282035
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78142989
157Hepatosplenomegaly (HP:0001433)1.77716064
158Agitation (HP:0000713)1.77474634
159Postaxial foot polydactyly (HP:0001830)1.77250127
160Small hand (HP:0200055)1.77054503
161Anencephaly (HP:0002323)1.76905524
162Aplasia/Hypoplasia of the patella (HP:0006498)1.76785024
163Abnormality of the phalanges of the 5th finger (HP:0004213)1.76292297
164Optic disc pallor (HP:0000543)1.76141898
165Abnormality of glycine metabolism (HP:0010895)1.76027374
166Abnormality of serine family amino acid metabolism (HP:0010894)1.76027374
167Pallor (HP:0000980)1.75750434
168Vaginal atresia (HP:0000148)1.73331172
169Renal tubular dysfunction (HP:0000124)1.73208535
170Metabolic alkalosis (HP:0200114)1.73112302
171Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72966072
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72858252
173Abnormal protein N-linked glycosylation (HP:0012347)1.72858252
174Abnormal protein glycosylation (HP:0012346)1.72858252
175Abnormal glycosylation (HP:0012345)1.72858252
176Thyroiditis (HP:0100646)1.72245888
177Abnormality of proline metabolism (HP:0010907)1.72051322
178Hydroxyprolinuria (HP:0003080)1.72051322
179Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71864005
180Abnormality of the middle phalanges of the toes (HP:0010183)1.71737581
181Nemaline bodies (HP:0003798)1.71186107
182Abnormality of methionine metabolism (HP:0010901)1.71049700
183Petechiae (HP:0000967)1.70303598
184Autoimmune thrombocytopenia (HP:0001973)1.70042107
185Bone cyst (HP:0012062)1.69987434
186Symphalangism affecting the phalanges of the hand (HP:0009773)1.69216929
187Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68726902
188Premature graying of hair (HP:0002216)1.68485804
189Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68081323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.27744018
2TAOK33.49742433
3NME22.90256919
4PBK2.73408181
5GRK12.72256996
6STK162.56198000
7MAP4K22.53211659
8BCKDK2.45596746
9EIF2AK12.35406869
10ZAK2.30280434
11CASK2.25157839
12PINK12.22279369
13BUB12.15242617
14IRAK32.03138055
15IRAK42.00961240
16OBSCN2.00319040
17WNK31.95117745
18MAP3K141.94829472
19ACVR1B1.90662527
20WEE11.86122805
21SIK31.78247928
22EIF2AK31.74309661
23SRPK11.72747953
24EIF2AK21.72166499
25PIM21.66417366
26TEC1.60191475
27PLK41.59267391
28TXK1.58569240
29MAPK131.58163548
30CDK81.57029346
31STK41.52958824
32PHKG21.52900038
33PHKG11.52900038
34BRSK21.48512484
35DAPK21.42550019
36BCR1.40562834
37NEK91.40242025
38VRK11.39655918
39MKNK11.39606851
40NUAK11.38994969
41WNK41.38381710
42BLK1.32483575
43MAP2K21.31318315
44TYK21.27034203
45MAP3K41.24754400
46IKBKB1.24131506
47FLT31.23927388
48MST41.21779310
49JAK31.19453763
50ADRBK11.16746696
51RPS6KA41.14071968
52KDR1.12013844
53PLK21.11329783
54TBK11.09658551
55KIT1.09083679
56BTK1.08563447
57TNIK1.08392725
58EPHA31.08123332
59INSRR1.06799944
60NLK1.05164871
61IKBKE1.04664301
62TRPM71.03473115
63ADRBK21.03342161
64GRK61.00197698
65PIK3CG0.99528344
66MYLK0.98997997
67PRKCE0.94951579
68PAK30.94043954
69MARK10.93678051
70TGFBR20.93413237
71MUSK0.91840958
72TGFBR10.91318810
73TLK10.90744236
74BMPR20.90484199
75ERBB30.90049348
76SIK20.89409634
77AURKB0.86587214
78PIK3CA0.86217140
79RPS6KB20.84126314
80MAP4K10.83100001
81DYRK30.82881684
82STK38L0.82554336
83PRKCG0.82146824
84STK240.82039307
85ATR0.81280783
86CSNK1G20.81051262
87BMPR1B0.81030983
88CDC70.80985561
89TIE10.77312508
90CAMKK20.77279914
91NTRK20.75536512
92IRAK10.75333926
93CDK70.73206727
94PTK2B0.73080907
95MAPK110.70948146
96LYN0.70522982
97CHUK0.70134790
98MAP2K70.69766849
99CSF1R0.68386451
100PIM10.68317739
101LIMK10.68252300
102MAP2K10.68022210
103NTRK30.67992626
104YES10.67013673
105MKNK20.66308320
106PNCK0.66274419
107ZAP700.66167018
108TRIM280.65906653
109CDK40.65686939
110RPS6KA50.65426782
111MAPKAPK30.65206557
112MELK0.64976557
113MAP2K60.64660068
114TTK0.63456986
115MAP2K30.62173852
116PRKCQ0.61423019
117CAMK2A0.60819127
118CSNK1G30.60668126
119PLK10.60077074
120MARK30.58676150
121SGK20.55685113
122CSNK2A10.55659200
123CSNK1G10.54468376
124GRK50.53595329
125BRSK10.53421194
126CLK10.53253132
127PRKACA0.50175615
128TAOK20.50076379
129FGFR40.48028826
130STK100.47865143
131TESK20.47458799
132GRK70.47383902
133ITK0.47312413
134ABL20.46672527
135STK30.45558676
136MAPKAPK20.45273319
137IGF1R0.44634488
138CDK30.43562192
139CSNK1A1L0.43299820
140STK390.42975126
141SYK0.41795315
142IRAK20.41267379
143DYRK20.40760473
144OXSR10.39357937
145CSNK1A10.37159284
146CSNK1D0.35533170
147FER0.34400215
148SGK2230.33779977
149SGK4940.33779977
150MAPK150.33329276
151PASK0.32457200
152PRKCA0.32254057
153ERBB20.29608982
154VRK20.29415558
155PKN10.29201529
156RPS6KA60.28229950
157ABL10.27949038
158PRKG10.27278502

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.02827366
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.99811112
3Ribosome_Homo sapiens_hsa030102.78918174
4DNA replication_Homo sapiens_hsa030302.69166498
5Phototransduction_Homo sapiens_hsa047442.58715568
6Linoleic acid metabolism_Homo sapiens_hsa005912.53393458
7Nicotine addiction_Homo sapiens_hsa050332.49776029
8Mismatch repair_Homo sapiens_hsa034302.26899205
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23569555
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21041254
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20162146
12Nitrogen metabolism_Homo sapiens_hsa009102.14776215
13Homologous recombination_Homo sapiens_hsa034402.11216698
14RNA polymerase_Homo sapiens_hsa030202.07051902
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03279222
16Pyrimidine metabolism_Homo sapiens_hsa002401.76382113
17Butanoate metabolism_Homo sapiens_hsa006501.71993211
18Base excision repair_Homo sapiens_hsa034101.71654985
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69819128
20Folate biosynthesis_Homo sapiens_hsa007901.65655032
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62639652
22Propanoate metabolism_Homo sapiens_hsa006401.60300500
23Fatty acid degradation_Homo sapiens_hsa000711.58771401
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58627081
25Peroxisome_Homo sapiens_hsa041461.58572656
26Fatty acid elongation_Homo sapiens_hsa000621.56397515
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56252463
28Oxidative phosphorylation_Homo sapiens_hsa001901.55227684
29One carbon pool by folate_Homo sapiens_hsa006701.52636140
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52629219
31Ether lipid metabolism_Homo sapiens_hsa005651.50508804
32Taste transduction_Homo sapiens_hsa047421.50310139
33Parkinsons disease_Homo sapiens_hsa050121.49159540
34Non-homologous end-joining_Homo sapiens_hsa034501.48212846
35Cardiac muscle contraction_Homo sapiens_hsa042601.48076342
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47809813
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45968308
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44027230
39Olfactory transduction_Homo sapiens_hsa047401.42504526
40Protein export_Homo sapiens_hsa030601.42382149
41Morphine addiction_Homo sapiens_hsa050321.41243260
42Nucleotide excision repair_Homo sapiens_hsa034201.41199394
43Spliceosome_Homo sapiens_hsa030401.37833216
44Basal transcription factors_Homo sapiens_hsa030221.33462760
45Allograft rejection_Homo sapiens_hsa053301.30754628
46Insulin secretion_Homo sapiens_hsa049111.30189090
47Steroid biosynthesis_Homo sapiens_hsa001001.28866482
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26100687
49Fanconi anemia pathway_Homo sapiens_hsa034601.23505736
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20137689
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19470714
52Circadian entrainment_Homo sapiens_hsa047131.19047316
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18975824
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17278458
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.16857191
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.13758413
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13707664
58Graft-versus-host disease_Homo sapiens_hsa053321.12554642
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11750764
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.11725331
61Serotonergic synapse_Homo sapiens_hsa047261.06048689
62NF-kappa B signaling pathway_Homo sapiens_hsa040641.05293899
63Glutathione metabolism_Homo sapiens_hsa004801.04619658
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03528230
65Tryptophan metabolism_Homo sapiens_hsa003801.03284962
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02453805
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01203154
68Herpes simplex infection_Homo sapiens_hsa051680.99612696
69RNA degradation_Homo sapiens_hsa030180.99500778
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97885471
71beta-Alanine metabolism_Homo sapiens_hsa004100.96301317
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95702190
73Huntingtons disease_Homo sapiens_hsa050160.95529578
74GABAergic synapse_Homo sapiens_hsa047270.95056165
75Carbon metabolism_Homo sapiens_hsa012000.93814533
76Salivary secretion_Homo sapiens_hsa049700.93727412
77Fatty acid metabolism_Homo sapiens_hsa012120.92762489
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92281570
79Staphylococcus aureus infection_Homo sapiens_hsa051500.91212867
80Legionellosis_Homo sapiens_hsa051340.91077955
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90474671
82Purine metabolism_Homo sapiens_hsa002300.89598804
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88685728
84Glutamatergic synapse_Homo sapiens_hsa047240.88583670
85Autoimmune thyroid disease_Homo sapiens_hsa053200.88207552
86Retinol metabolism_Homo sapiens_hsa008300.87529627
87ABC transporters_Homo sapiens_hsa020100.87424652
88RNA transport_Homo sapiens_hsa030130.87300225
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87248451
90Cell cycle_Homo sapiens_hsa041100.86733409
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.86685826
92Histidine metabolism_Homo sapiens_hsa003400.86550103
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86400325
94Measles_Homo sapiens_hsa051620.84892935
95Ovarian steroidogenesis_Homo sapiens_hsa049130.84236651
96Calcium signaling pathway_Homo sapiens_hsa040200.83480522
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80889790
98Arachidonic acid metabolism_Homo sapiens_hsa005900.79494806
99Chemical carcinogenesis_Homo sapiens_hsa052040.79425579
100Caffeine metabolism_Homo sapiens_hsa002320.78640829
101Amphetamine addiction_Homo sapiens_hsa050310.78208904
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77849083
103Arginine and proline metabolism_Homo sapiens_hsa003300.77670715
104Circadian rhythm_Homo sapiens_hsa047100.75527373
105Pentose phosphate pathway_Homo sapiens_hsa000300.75271543
106Alzheimers disease_Homo sapiens_hsa050100.74317125
107Gastric acid secretion_Homo sapiens_hsa049710.73426789
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73088658
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.72921238
110Primary immunodeficiency_Homo sapiens_hsa053400.72845528
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72771600
112Fat digestion and absorption_Homo sapiens_hsa049750.72302041
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72192534
114Sulfur metabolism_Homo sapiens_hsa009200.71926340
115Metabolic pathways_Homo sapiens_hsa011000.71831929
116Vitamin digestion and absorption_Homo sapiens_hsa049770.70020159
117Glycerolipid metabolism_Homo sapiens_hsa005610.69952228
118Selenocompound metabolism_Homo sapiens_hsa004500.68567188
119Renin secretion_Homo sapiens_hsa049240.68022110
120Pyruvate metabolism_Homo sapiens_hsa006200.67088282
121Regulation of autophagy_Homo sapiens_hsa041400.66305466
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65287426
123p53 signaling pathway_Homo sapiens_hsa041150.62709219
124Tyrosine metabolism_Homo sapiens_hsa003500.62516478
125Complement and coagulation cascades_Homo sapiens_hsa046100.61677026
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60200277
127Dopaminergic synapse_Homo sapiens_hsa047280.59537214
128Leishmaniasis_Homo sapiens_hsa051400.59017801
129Systemic lupus erythematosus_Homo sapiens_hsa053220.58739061
130Malaria_Homo sapiens_hsa051440.58675607
131Epstein-Barr virus infection_Homo sapiens_hsa051690.56581314
132Hematopoietic cell lineage_Homo sapiens_hsa046400.55032998
133Asthma_Homo sapiens_hsa053100.54690194
134Influenza A_Homo sapiens_hsa051640.54252820
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53869702
136Type I diabetes mellitus_Homo sapiens_hsa049400.52218089
137Mineral absorption_Homo sapiens_hsa049780.52130451
138Biosynthesis of amino acids_Homo sapiens_hsa012300.51759610
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48573133
140Cocaine addiction_Homo sapiens_hsa050300.48356965
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.46678527
142Dorso-ventral axis formation_Homo sapiens_hsa043200.42756096
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.42706734
144Starch and sucrose metabolism_Homo sapiens_hsa005000.42170788
145Oxytocin signaling pathway_Homo sapiens_hsa049210.41914098
146Cholinergic synapse_Homo sapiens_hsa047250.41113048
147cAMP signaling pathway_Homo sapiens_hsa040240.36629410
148Long-term depression_Homo sapiens_hsa047300.34410712
149Collecting duct acid secretion_Homo sapiens_hsa049660.33674757
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31631645

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