APOOP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.58019922
2centriole replication (GO:0007099)4.68935304
3epithelial cilium movement (GO:0003351)4.11169484
4pyrimidine nucleobase catabolic process (GO:0006208)3.84608706
5fucose catabolic process (GO:0019317)3.74948525
6L-fucose metabolic process (GO:0042354)3.74948525
7L-fucose catabolic process (GO:0042355)3.74948525
8protein localization to cilium (GO:0061512)3.73193205
9intraciliary transport (GO:0042073)3.68991334
10regulation of hippo signaling (GO:0035330)3.65169258
11negative regulation of telomere maintenance (GO:0032205)3.58181577
12protein-cofactor linkage (GO:0018065)3.56587702
13regulation of synapse structural plasticity (GO:0051823)3.50941901
14negative regulation of mast cell activation (GO:0033004)3.49526500
15nephron epithelium morphogenesis (GO:0072088)3.48027694
16nephron tubule morphogenesis (GO:0072078)3.48027694
17platelet dense granule organization (GO:0060155)3.45353148
18transmission of nerve impulse (GO:0019226)3.45070545
19water-soluble vitamin biosynthetic process (GO:0042364)3.39570256
20synaptic transmission, cholinergic (GO:0007271)3.38998393
21regulation of gene silencing by RNA (GO:0060966)3.31282162
22regulation of posttranscriptional gene silencing (GO:0060147)3.31282162
23regulation of gene silencing by miRNA (GO:0060964)3.31282162
24cilium movement (GO:0003341)3.30949874
25dendritic spine morphogenesis (GO:0060997)3.30318289
26postsynaptic membrane organization (GO:0001941)3.29992256
27piRNA metabolic process (GO:0034587)3.28200048
28response to pheromone (GO:0019236)3.25071471
29centriole assembly (GO:0098534)3.24445357
30gamma-aminobutyric acid transport (GO:0015812)3.19542704
31nucleobase catabolic process (GO:0046113)3.18668186
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17835602
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17691374
34cilium assembly (GO:0042384)3.16757494
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15035797
36thalamus development (GO:0021794)3.13067524
37cilium organization (GO:0044782)3.11022703
38N-acetylglucosamine metabolic process (GO:0006044)3.03004400
39ketone body metabolic process (GO:1902224)3.02198074
40neuronal action potential (GO:0019228)3.01392339
41neurofilament cytoskeleton organization (GO:0060052)3.00980805
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98547959
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.98547959
44NADH dehydrogenase complex assembly (GO:0010257)2.98547959
45protein polyglutamylation (GO:0018095)2.98131768
46negative regulation of transcription regulatory region DNA binding (GO:2000678)2.94414477
47renal tubule morphogenesis (GO:0061333)2.89297427
48ATP synthesis coupled proton transport (GO:0015986)2.86490263
49energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86490263
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86185555
51respiratory chain complex IV assembly (GO:0008535)2.84530598
52cellular ketone body metabolic process (GO:0046950)2.83660088
53nonmotile primary cilium assembly (GO:0035058)2.82540578
54glycosphingolipid biosynthetic process (GO:0006688)2.80701153
55regulation of action potential (GO:0098900)2.72082582
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69142831
57cilium morphogenesis (GO:0060271)2.68732084
58neuromuscular synaptic transmission (GO:0007274)2.68647390
59retinal ganglion cell axon guidance (GO:0031290)2.68509465
60axoneme assembly (GO:0035082)2.68264488
61DNA deamination (GO:0045006)2.67445344
62protein neddylation (GO:0045116)2.66948929
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.65242632
64fucosylation (GO:0036065)2.63778855
65electron transport chain (GO:0022900)2.63716846
66hydrogen ion transmembrane transport (GO:1902600)2.61421927
67hindbrain development (GO:0030902)2.59726279
68regulation of glucokinase activity (GO:0033131)2.58811028
69regulation of hexokinase activity (GO:1903299)2.58811028
70protein complex biogenesis (GO:0070271)2.58338763
71mitochondrial respiratory chain complex assembly (GO:0033108)2.55876991
72multicellular organism reproduction (GO:0032504)2.55335552
73respiratory electron transport chain (GO:0022904)2.52780734
74peristalsis (GO:0030432)2.51160071
75spinal cord development (GO:0021510)2.50432654
76proton transport (GO:0015992)2.48461468
77limb bud formation (GO:0060174)2.47917261
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47125522
79negative regulation of nitric-oxide synthase activity (GO:0051001)2.46304794
80protein import into peroxisome matrix (GO:0016558)2.46278928
81ubiquinone biosynthetic process (GO:0006744)2.45623803
82DNA methylation involved in gamete generation (GO:0043046)2.44649686
83positive regulation of histone H3-K4 methylation (GO:0051571)2.44598816
84negative regulation of reactive oxygen species metabolic process (GO:2000378)2.44540857
85kidney morphogenesis (GO:0060993)2.44493271
86positive regulation of fatty acid transport (GO:2000193)2.44170727
87hydrogen transport (GO:0006818)2.40478350
88neural tube formation (GO:0001841)2.40424873
89negative regulation of execution phase of apoptosis (GO:1900118)2.40356218
90opioid receptor signaling pathway (GO:0038003)2.40302769
91cornea development in camera-type eye (GO:0061303)2.39015309
92ubiquinone metabolic process (GO:0006743)2.38711736
93behavioral response to ethanol (GO:0048149)2.36705417
94positive regulation of prostaglandin secretion (GO:0032308)2.36636081
95ATP hydrolysis coupled proton transport (GO:0015991)2.36285687
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.36285687
97base-excision repair, AP site formation (GO:0006285)2.36258620
98somite development (GO:0061053)2.36232190
99regulation of telomere maintenance (GO:0032204)2.34632954
100positive regulation of triglyceride biosynthetic process (GO:0010867)2.34584813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.17846749
2EZH2_22144423_ChIP-Seq_EOC_Human3.45029201
3VDR_22108803_ChIP-Seq_LS180_Human3.20144605
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10516364
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06573670
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44907153
7GBX2_23144817_ChIP-Seq_PC3_Human2.38282793
8IGF1R_20145208_ChIP-Seq_DFB_Human2.29845398
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28790563
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16159493
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10775118
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01664917
13ER_23166858_ChIP-Seq_MCF-7_Human1.86529652
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.86161452
15FUS_26573619_Chip-Seq_HEK293_Human1.81481729
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.80621526
17P300_19829295_ChIP-Seq_ESCs_Human1.80470177
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73947529
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73485198
20BCAT_22108803_ChIP-Seq_LS180_Human1.73150364
21REST_21632747_ChIP-Seq_MESCs_Mouse1.70267836
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67233612
23EWS_26573619_Chip-Seq_HEK293_Human1.65010078
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62622250
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.59995662
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59540490
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.59043740
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58702805
29TAF15_26573619_Chip-Seq_HEK293_Human1.52564630
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52390296
31TP53_22573176_ChIP-Seq_HFKS_Human1.51750444
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50492721
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47869293
34IRF1_19129219_ChIP-ChIP_H3396_Human1.47850794
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.46937738
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42700496
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40693482
38SOX2_19829295_ChIP-Seq_ESCs_Human1.35914864
39NANOG_19829295_ChIP-Seq_ESCs_Human1.35914864
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35372677
41AR_21572438_ChIP-Seq_LNCaP_Human1.34462048
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33913695
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32215823
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29887778
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29390916
46RNF2_27304074_Chip-Seq_NSC_Mouse1.29185946
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27504338
48HOXB7_26014856_ChIP-Seq_BT474_Human1.27464605
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.24722651
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24514209
51SMAD4_21799915_ChIP-Seq_A2780_Human1.22525329
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22497645
53RUNX2_22187159_ChIP-Seq_PCA_Human1.21591499
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20137685
55STAT3_23295773_ChIP-Seq_U87_Human1.19328990
56AR_25329375_ChIP-Seq_VCAP_Human1.17642297
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17386874
58TCF4_23295773_ChIP-Seq_U87_Human1.16971315
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16812269
60NCOR_22424771_ChIP-Seq_293T_Human1.16744625
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16625719
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.16275091
63MYC_18940864_ChIP-ChIP_HL60_Human1.16069432
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.16057064
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.15703674
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14524048
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14213143
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.13402323
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12262647
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.12262647
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11918263
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11162089
73CBP_20019798_ChIP-Seq_JUKART_Human1.11162089
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.11123867
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11068048
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09528738
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.07955810
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07782525
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07623726
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.05936646
81DROSHA_22980978_ChIP-Seq_HELA_Human1.05841178
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05658902
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05612889
84VDR_23849224_ChIP-Seq_CD4+_Human1.05190615
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.05021561
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04889155
87JUN_21703547_ChIP-Seq_K562_Human1.04204186
88TCF4_22108803_ChIP-Seq_LS180_Human1.03642746
89ELK1_19687146_ChIP-ChIP_HELA_Human1.03551124
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03500647
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.03391045
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03298335
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.02102035
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01821033
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.01625451
96P53_22387025_ChIP-Seq_ESCs_Mouse1.01053457
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00764803
98AR_20517297_ChIP-Seq_VCAP_Human1.00706528
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00648123
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.00514685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation3.84355122
2MP0003195_calcinosis2.87440914
3MP0000372_irregular_coat_pigmentation2.84882771
4MP0004885_abnormal_endolymph2.75955448
5MP0002102_abnormal_ear_morphology2.67671030
6MP0008877_abnormal_DNA_methylation2.54248180
7MP0004133_heterotaxia2.44732766
8MP0005083_abnormal_biliary_tract2.43003957
9MP0001529_abnormal_vocalization2.18192574
10MP0005551_abnormal_eye_electrophysiolog2.15894617
11MP0004043_abnormal_pH_regulation2.13855029
12MP0003880_abnormal_central_pattern2.05417817
13MP0002822_catalepsy2.04637080
14MP0004142_abnormal_muscle_tone2.00412386
15MP0009745_abnormal_behavioral_response2.00398917
16MP0006276_abnormal_autonomic_nervous1.99063593
17MP0008872_abnormal_physiological_respon1.96215947
18MP0004742_abnormal_vestibular_system1.85647699
19MP0002837_dystrophic_cardiac_calcinosis1.82227755
20MP0002272_abnormal_nervous_system1.79828996
21MP0005645_abnormal_hypothalamus_physiol1.76613780
22MP0008058_abnormal_DNA_repair1.74634496
23MP0004145_abnormal_muscle_electrophysio1.73697767
24MP0005365_abnormal_bile_salt1.73447459
25MP0002938_white_spotting1.71609355
26MP0001486_abnormal_startle_reflex1.71302233
27MP0002736_abnormal_nociception_after1.71294597
28MP0001968_abnormal_touch/_nociception1.70651913
29MP0000778_abnormal_nervous_system1.54194136
30MP0008875_abnormal_xenobiotic_pharmacok1.53019013
31MP0005253_abnormal_eye_physiology1.52480578
32MP0005646_abnormal_pituitary_gland1.51075934
33MP0009046_muscle_twitch1.50803035
34MP0002064_seizures1.46175743
35MP0004147_increased_porphyrin_level1.45922387
36MP0008961_abnormal_basal_metabolism1.45097720
37MP0002735_abnormal_chemical_nociception1.44564866
38MP0003136_yellow_coat_color1.44490369
39MP0002572_abnormal_emotion/affect_behav1.44024370
40MP0002876_abnormal_thyroid_physiology1.39384656
41MP0005075_abnormal_melanosome_morpholog1.39267159
42MP0003635_abnormal_synaptic_transmissio1.38231779
43MP0002638_abnormal_pupillary_reflex1.33997419
44MP0005084_abnormal_gallbladder_morpholo1.33628101
45MP0005389_reproductive_system_phenotype1.32662344
46MP0002733_abnormal_thermal_nociception1.31313393
47MP0006072_abnormal_retinal_apoptosis1.30874825
48MP0002557_abnormal_social/conspecific_i1.30076518
49MP0002067_abnormal_sensory_capabilities1.28822750
50MP0002095_abnormal_skin_pigmentation1.28720572
51MP0002254_reproductive_system_inflammat1.26367180
52MP0002063_abnormal_learning/memory/cond1.26262440
53MP0001984_abnormal_olfaction1.25863161
54MP0000631_abnormal_neuroendocrine_gland1.25261205
55MP0001970_abnormal_pain_threshold1.24612375
56MP0001919_abnormal_reproductive_system1.23469182
57MP0001485_abnormal_pinna_reflex1.23107423
58MP0000955_abnormal_spinal_cord1.22981804
59MP0003878_abnormal_ear_physiology1.17334108
60MP0005377_hearing/vestibular/ear_phenot1.17334108
61MP0002160_abnormal_reproductive_system1.16465737
62MP0003252_abnormal_bile_duct1.15999237
63MP0006292_abnormal_olfactory_placode1.15736998
64MP0003787_abnormal_imprinting1.13199831
65MP0001324_abnormal_eye_pigmentation1.10158262
66MP0002184_abnormal_innervation1.09880968
67MP0008995_early_reproductive_senescence1.09004735
68MP0005167_abnormal_blood-brain_barrier1.07454395
69MP0000026_abnormal_inner_ear1.06753554
70MP0002752_abnormal_somatic_nervous1.06469363
71MP0002928_abnormal_bile_duct1.03762523
72MP0002734_abnormal_mechanical_nocicepti0.99794527
73MP0005187_abnormal_penis_morphology0.99289397
74MP0005195_abnormal_posterior_eye0.95944817
75MP0003806_abnormal_nucleotide_metabolis0.95783123
76MP0002229_neurodegeneration0.95395238
77MP0001986_abnormal_taste_sensitivity0.94733993
78MP0002277_abnormal_respiratory_mucosa0.94208241
79MP0005386_behavior/neurological_phenoty0.94104593
80MP0004924_abnormal_behavior0.94104593
81MP0000427_abnormal_hair_cycle0.94059514
82MP0010386_abnormal_urinary_bladder0.91705121
83MP0001764_abnormal_homeostasis0.91605560
84MP0005174_abnormal_tail_pigmentation0.91320579
85MP0003698_abnormal_male_reproductive0.88611652
86MP0002882_abnormal_neuron_morphology0.88573669
87MP0000015_abnormal_ear_pigmentation0.87798402
88MP0002751_abnormal_autonomic_nervous0.87221856
89MP0000013_abnormal_adipose_tissue0.84251273
90MP0004270_analgesia0.83931830
91MP0001905_abnormal_dopamine_level0.83612898
92MP0004019_abnormal_vitamin_homeostasis0.83527910
93MP0003137_abnormal_impulse_conducting0.81424005
94MP0000230_abnormal_systemic_arterial0.81130330
95MP0001963_abnormal_hearing_physiology0.80486811
96MP0003283_abnormal_digestive_organ0.80302924
97MP0000383_abnormal_hair_follicle0.80261249
98MP0010329_abnormal_lipoprotein_level0.80066018
99MP0000647_abnormal_sebaceous_gland0.79794144
100MP0002210_abnormal_sex_determination0.77860090

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.19749731
2Molar tooth sign on MRI (HP:0002419)4.19749731
3Type II lissencephaly (HP:0007260)4.15805412
4Nephronophthisis (HP:0000090)4.02749782
5Pancreatic cysts (HP:0001737)4.01262790
6Pancreatic fibrosis (HP:0100732)3.94040461
7True hermaphroditism (HP:0010459)3.76105810
8Abnormality of the renal medulla (HP:0100957)3.36222881
9Chronic hepatic failure (HP:0100626)3.28520101
10Retinal dysplasia (HP:0007973)3.27319494
11Abnormality of the renal cortex (HP:0011035)3.21837331
12Inability to walk (HP:0002540)3.17117387
13Pendular nystagmus (HP:0012043)3.04343748
14Congenital stationary night blindness (HP:0007642)3.00141170
15Increased hepatocellular lipid droplets (HP:0006565)2.92668367
16Lissencephaly (HP:0001339)2.91440411
17Lipid accumulation in hepatocytes (HP:0006561)2.86421595
18Abolished electroretinogram (ERG) (HP:0000550)2.81128056
19Type 2 muscle fiber atrophy (HP:0003554)2.73402947
20Pachygyria (HP:0001302)2.73325763
21Medial flaring of the eyebrow (HP:0010747)2.64547839
22Progressive inability to walk (HP:0002505)2.57011277
23Acute necrotizing encephalopathy (HP:0006965)2.56741396
24Mitochondrial inheritance (HP:0001427)2.55246248
25Sclerocornea (HP:0000647)2.50667569
26Anencephaly (HP:0002323)2.49526313
27Birth length less than 3rd percentile (HP:0003561)2.45581660
28Severe visual impairment (HP:0001141)2.41698262
29Progressive cerebellar ataxia (HP:0002073)2.41174555
30Renal Fanconi syndrome (HP:0001994)2.40975120
31Occipital encephalocele (HP:0002085)2.37284183
32Broad-based gait (HP:0002136)2.36986929
33Renal cortical cysts (HP:0000803)2.35930044
34Cystic liver disease (HP:0006706)2.35457016
35Tubular atrophy (HP:0000092)2.32995334
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.32958166
37Acute encephalopathy (HP:0006846)2.31091137
38Increased CSF lactate (HP:0002490)2.26439889
39Rib fusion (HP:0000902)2.26006594
40Concave nail (HP:0001598)2.24719331
41Neoplasm of the adrenal cortex (HP:0100641)2.24108618
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.22861880
43Gait imbalance (HP:0002141)2.15307405
44Large for gestational age (HP:0001520)2.14375542
45Bile duct proliferation (HP:0001408)2.12280699
46Abnormal biliary tract physiology (HP:0012439)2.12280699
47Progressive macrocephaly (HP:0004481)2.10618833
48Limb dystonia (HP:0002451)2.10606951
49Polydipsia (HP:0001959)2.09676895
50Abnormal drinking behavior (HP:0030082)2.09676895
51Congenital hepatic fibrosis (HP:0002612)2.08126101
52Muscle fiber atrophy (HP:0100295)2.08080557
53Metabolic alkalosis (HP:0200114)2.07280729
54Short tibia (HP:0005736)2.06642377
55Optic disc pallor (HP:0000543)2.06466972
56Parakeratosis (HP:0001036)2.05878863
57Abnormality of alanine metabolism (HP:0010916)2.04990871
58Hyperalaninemia (HP:0003348)2.04990871
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04990871
60Keratoconus (HP:0000563)2.04775106
61Increased corneal curvature (HP:0100692)2.04775106
62Postaxial foot polydactyly (HP:0001830)2.03968808
63Delayed CNS myelination (HP:0002188)2.03691771
64Anterior segment dysgenesis (HP:0007700)2.02228475
65Decreased central vision (HP:0007663)1.98723326
66Abnormal mitochondria in muscle tissue (HP:0008316)1.98401238
67Brushfield spots (HP:0001088)1.96829927
68Abnormal rod and cone electroretinograms (HP:0008323)1.96289883
69Congenital primary aphakia (HP:0007707)1.95559819
70Postaxial hand polydactyly (HP:0001162)1.93200873
71Attenuation of retinal blood vessels (HP:0007843)1.91998916
72Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91906248
73Polyuria (HP:0000103)1.91654031
74Agitation (HP:0000713)1.90940991
75Exertional dyspnea (HP:0002875)1.90358624
76Abnormality of renal resorption (HP:0011038)1.88210586
77Hypomagnesemia (HP:0002917)1.87359002
78Aplasia/Hypoplasia of the patella (HP:0006498)1.85615304
79Patellar aplasia (HP:0006443)1.81184092
80Genital tract atresia (HP:0001827)1.81081465
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80316952
82Hypokalemic alkalosis (HP:0001949)1.77937189
83Asplenia (HP:0001746)1.77763695
84Optic nerve hypoplasia (HP:0000609)1.77730096
85Epidermoid cyst (HP:0200040)1.75489490
86Male pseudohermaphroditism (HP:0000037)1.75343388
87Abnormal number of erythroid precursors (HP:0012131)1.75069841
88Furrowed tongue (HP:0000221)1.74754517
89Aplasia of the musculature (HP:0100854)1.73641492
90Fibular aplasia (HP:0002990)1.72434223
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.72411794
92Cerebral edema (HP:0002181)1.71148759
93Cerebellar dysplasia (HP:0007033)1.70941053
94Tachypnea (HP:0002789)1.70808660
95Nephrogenic diabetes insipidus (HP:0009806)1.70051594
96Bony spicule pigmentary retinopathy (HP:0007737)1.67926455
97IgG deficiency (HP:0004315)1.67882573
98Methylmalonic aciduria (HP:0012120)1.67591918
99Long clavicles (HP:0000890)1.67192372
1003-Methylglutaconic aciduria (HP:0003535)1.66144862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.15183191
2WNK44.02695784
3TNIK3.33467611
4MARK13.00225291
5MAP4K22.85001972
6ADRBK22.82683047
7CCNB12.73546574
8FRK2.63695682
9STK392.49740796
10GRK12.37157592
11CAMKK22.22187281
12NEK22.19375813
13WNK32.08788948
14CAMK1D1.91314610
15NUAK11.65971445
16CASK1.65898317
17PINK11.61441897
18OXSR11.55510407
19DAPK21.50783580
20DYRK21.49364966
21INSRR1.47318131
22ZAK1.46427629
23MAPK131.45842337
24MAP3K41.45468393
25NTRK21.39740198
26TAF11.34262465
27CAMK1G1.33646938
28BMPR1B1.20087072
29PAK31.16408312
30TLK11.06954119
31PNCK1.06475706
32PRKCG1.05419096
33GRK71.03495379
34ADRBK10.97141452
35MUSK0.95435255
36MAP3K120.89984321
37EIF2AK30.89371698
38TXK0.87287116
39NTRK30.81443049
40MAPK150.80478520
41MAP2K70.79466050
42GRK50.75332758
43MINK10.75213043
44VRK20.75132379
45CSNK1G20.74417582
46VRK10.69600567
47BCKDK0.69482989
48CAMKK10.67508901
49WNK10.67092027
50STK160.65960543
51CAMK10.65669727
52NME10.64082444
53TNK20.63841255
54CHUK0.63660375
55MAPKAPK50.58534066
56MAP2K40.57641269
57TRIM280.57326117
58CSNK1G30.56593835
59WEE10.53337249
60DAPK30.53299437
61DYRK30.53208290
62PRKCQ0.51839624
63CSNK1G10.50773673
64RPS6KA50.49339904
65PRKCH0.48892041
66LIMK10.47929453
67PASK0.46918065
68PKN10.46453178
69PRKACA0.45638367
70OBSCN0.45167301
71MAP3K70.45157992
72TYRO30.42753954
73CSNK1D0.39205575
74CDC70.37860498
75CSNK1A10.37677635
76CAMK2A0.37356407
77PRKCE0.37040717
78PRKCI0.36518778
79CSNK1E0.34917438
80CSNK1A1L0.34312097
81PHKG20.33739230
82PHKG10.33739230
83EPHA30.33534805
84PAK60.33249999
85MAPK40.32855816
86YES10.32652791
87MST40.32386338
88PLK10.31494578
89PRKCA0.30879882
90CHEK20.30450614
91RPS6KB10.29417028
92CSNK2A10.29184448
93PRKACB0.28924703
94PRKCZ0.28546726
95CDK190.28508496
96MAP3K110.28427353
97DAPK10.27258569
98CDK50.26899249
99KIT0.26490967
100ERBB30.26237044

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.42692290
2Nitrogen metabolism_Homo sapiens_hsa009102.97002099
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.81857884
4Parkinsons disease_Homo sapiens_hsa050122.73802471
5Phototransduction_Homo sapiens_hsa047442.61369173
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.60573336
7Nicotine addiction_Homo sapiens_hsa050332.55980794
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.28079425
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24379659
10Butanoate metabolism_Homo sapiens_hsa006502.24115862
11Basal transcription factors_Homo sapiens_hsa030222.23380155
12Linoleic acid metabolism_Homo sapiens_hsa005912.19609671
13Cardiac muscle contraction_Homo sapiens_hsa042602.16875745
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01247660
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00075725
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98990310
17Alzheimers disease_Homo sapiens_hsa050101.84926990
18Caffeine metabolism_Homo sapiens_hsa002321.74298023
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69135694
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65705154
21Ribosome_Homo sapiens_hsa030101.61681236
22Huntingtons disease_Homo sapiens_hsa050161.60455340
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56882938
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53460166
25Ether lipid metabolism_Homo sapiens_hsa005651.41241690
26Selenocompound metabolism_Homo sapiens_hsa004501.38713197
27Collecting duct acid secretion_Homo sapiens_hsa049661.38269030
28Olfactory transduction_Homo sapiens_hsa047401.35915355
29RNA polymerase_Homo sapiens_hsa030201.29528119
30Peroxisome_Homo sapiens_hsa041461.29154908
31Morphine addiction_Homo sapiens_hsa050321.28104913
32Protein export_Homo sapiens_hsa030601.26907114
33Propanoate metabolism_Homo sapiens_hsa006401.22264793
34Tryptophan metabolism_Homo sapiens_hsa003801.21842520
35Homologous recombination_Homo sapiens_hsa034401.20921070
36Fanconi anemia pathway_Homo sapiens_hsa034601.16347189
37Taste transduction_Homo sapiens_hsa047421.15733619
38Glutamatergic synapse_Homo sapiens_hsa047241.07185582
39Regulation of autophagy_Homo sapiens_hsa041401.07035876
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06393686
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06236678
42GABAergic synapse_Homo sapiens_hsa047271.04021274
43Fat digestion and absorption_Homo sapiens_hsa049751.02649308
44Primary immunodeficiency_Homo sapiens_hsa053401.00150727
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.99906101
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98436569
47Synaptic vesicle cycle_Homo sapiens_hsa047210.97796273
48Steroid biosynthesis_Homo sapiens_hsa001000.96200670
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.95901312
50Vitamin B6 metabolism_Homo sapiens_hsa007500.95831054
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.94918605
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91794049
53Retinol metabolism_Homo sapiens_hsa008300.90058430
54Arachidonic acid metabolism_Homo sapiens_hsa005900.87129583
55Insulin secretion_Homo sapiens_hsa049110.86501272
56Chemical carcinogenesis_Homo sapiens_hsa052040.86019555
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85116557
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83139874
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82861565
60Sulfur relay system_Homo sapiens_hsa041220.80241401
61Circadian entrainment_Homo sapiens_hsa047130.80188466
62Serotonergic synapse_Homo sapiens_hsa047260.79697424
63Cocaine addiction_Homo sapiens_hsa050300.77633337
64Axon guidance_Homo sapiens_hsa043600.77307310
65One carbon pool by folate_Homo sapiens_hsa006700.77283974
66Fatty acid biosynthesis_Homo sapiens_hsa000610.76477343
67Fatty acid degradation_Homo sapiens_hsa000710.68012383
68Dopaminergic synapse_Homo sapiens_hsa047280.67610067
69Purine metabolism_Homo sapiens_hsa002300.67426540
70Nucleotide excision repair_Homo sapiens_hsa034200.66722398
71Metabolic pathways_Homo sapiens_hsa011000.65864477
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65079336
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64970290
74RNA degradation_Homo sapiens_hsa030180.62935410
75Amphetamine addiction_Homo sapiens_hsa050310.61752680
76Calcium signaling pathway_Homo sapiens_hsa040200.56514614
77Cholinergic synapse_Homo sapiens_hsa047250.55888777
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54139815
79ABC transporters_Homo sapiens_hsa020100.52457689
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52260143
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51443461
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49993904
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.47996293
84Hedgehog signaling pathway_Homo sapiens_hsa043400.45567923
85Fatty acid metabolism_Homo sapiens_hsa012120.45127408
86Basal cell carcinoma_Homo sapiens_hsa052170.44821129
87Pyruvate metabolism_Homo sapiens_hsa006200.44809452
88Ovarian steroidogenesis_Homo sapiens_hsa049130.41449819
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40375278
90Alcoholism_Homo sapiens_hsa050340.38603810
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36933524
92Pyrimidine metabolism_Homo sapiens_hsa002400.36146399
93Glycerolipid metabolism_Homo sapiens_hsa005610.34365689
94Salivary secretion_Homo sapiens_hsa049700.32609001
95Proteasome_Homo sapiens_hsa030500.31681105
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30089860
97Oxytocin signaling pathway_Homo sapiens_hsa049210.28919753
98Rheumatoid arthritis_Homo sapiens_hsa053230.26485046
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26275388
100Melanoma_Homo sapiens_hsa052180.26183105

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »