APP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06771504
2synaptic vesicle maturation (GO:0016188)4.93744411
3locomotory exploration behavior (GO:0035641)4.85898112
4vocalization behavior (GO:0071625)4.71857660
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70021240
6synaptic vesicle exocytosis (GO:0016079)4.59651557
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.57504212
8hemidesmosome assembly (GO:0031581)4.38273585
9glutamate secretion (GO:0014047)4.32822675
10neuron cell-cell adhesion (GO:0007158)4.30164069
11regulation of synaptic vesicle exocytosis (GO:2000300)4.27112438
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27069859
13neuronal action potential propagation (GO:0019227)4.20588397
14layer formation in cerebral cortex (GO:0021819)4.02192859
15protein localization to synapse (GO:0035418)3.98907215
16regulation of glutamate receptor signaling pathway (GO:1900449)3.93387322
17* ionotropic glutamate receptor signaling pathway (GO:0035235)3.82954696
18exploration behavior (GO:0035640)3.82107624
19cellular potassium ion homeostasis (GO:0030007)3.79932678
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79272789
21dendritic spine morphogenesis (GO:0060997)3.75609763
22regulation of neuronal synaptic plasticity (GO:0048168)3.71837635
23regulation of synaptic vesicle transport (GO:1902803)3.71268691
24neurotransmitter secretion (GO:0007269)3.67525050
25* glutamate receptor signaling pathway (GO:0007215)3.56406905
26gamma-aminobutyric acid transport (GO:0015812)3.52801658
27regulation of synapse structural plasticity (GO:0051823)3.49082082
28transmission of nerve impulse (GO:0019226)3.47980606
29synaptic transmission, glutamatergic (GO:0035249)3.47550436
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.47019029
31* neuron recognition (GO:0008038)3.45675962
32sodium ion export (GO:0071436)3.44652390
33axonal fasciculation (GO:0007413)3.42063916
34neuron-neuron synaptic transmission (GO:0007270)3.40819994
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.38963830
36long-term memory (GO:0007616)3.29515661
37central nervous system myelination (GO:0022010)3.27523314
38axon ensheathment in central nervous system (GO:0032291)3.27523314
39regulation of dendritic spine morphogenesis (GO:0061001)3.26602686
40protein localization to endosome (GO:0036010)3.26153453
41skin morphogenesis (GO:0043589)3.26145859
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24400536
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23787620
44semaphorin-plexin signaling pathway (GO:0071526)3.16435362
45neurotransmitter transport (GO:0006836)3.15191855
46proline transport (GO:0015824)3.14993695
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13095457
48dendrite morphogenesis (GO:0048813)3.11223116
49positive regulation of membrane potential (GO:0045838)3.10553587
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10495048
51regulation of postsynaptic membrane potential (GO:0060078)3.09809897
52cell adhesion mediated by integrin (GO:0033627)3.08005190
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07884037
54L-amino acid import (GO:0043092)3.05996136
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05965260
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05637860
57protein retention in ER lumen (GO:0006621)3.05259687
58regulation of synaptic plasticity (GO:0048167)3.05026486
59neurotransmitter-gated ion channel clustering (GO:0072578)3.02941857
60activation of protein kinase A activity (GO:0034199)3.02727963
61neuronal ion channel clustering (GO:0045161)3.01411725
62long-term synaptic potentiation (GO:0060291)2.99945472
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.98827668
64cell-substrate junction assembly (GO:0007044)2.97438872
65apical protein localization (GO:0045176)2.97347309
66glycine transport (GO:0015816)2.97334473
67regulation of vesicle fusion (GO:0031338)2.93803632
68synaptic vesicle endocytosis (GO:0048488)2.92902060
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91633474
70positive regulation of synapse maturation (GO:0090129)2.91463622
71* neuromuscular process controlling balance (GO:0050885)2.90874998
72presynaptic membrane assembly (GO:0097105)2.90629788
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88741236
74regulation of neurotransmitter levels (GO:0001505)2.88210062
75regulation of synaptic transmission, glutamatergic (GO:0051966)2.87625959
76regulation of dendritic spine development (GO:0060998)2.87583402
77amino acid import (GO:0043090)2.87397017
78presynaptic membrane organization (GO:0097090)2.87205812
79cerebellar granule cell differentiation (GO:0021707)2.85348314
80adult walking behavior (GO:0007628)2.83534862
81regulation of neurotransmitter secretion (GO:0046928)2.83445537
82negative regulation of neurotransmitter transport (GO:0051589)2.82483494
83vesicle transport along microtubule (GO:0047496)2.81964162
84dendritic spine organization (GO:0097061)2.81458304
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77748965
86auditory behavior (GO:0031223)2.77357337
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75811277
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75567183
89neuromuscular process controlling posture (GO:0050884)2.74410897
90potassium ion import (GO:0010107)2.73470355
91axon extension (GO:0048675)2.72555742
92endothelial cell chemotaxis (GO:0035767)2.72188095
93membrane hyperpolarization (GO:0060081)2.71642177
94postsynaptic membrane organization (GO:0001941)2.71323485
95cerebellar Purkinje cell differentiation (GO:0021702)2.70731686
96prepulse inhibition (GO:0060134)2.70455667
97cell migration in hindbrain (GO:0021535)2.70045219
98membrane depolarization (GO:0051899)2.70033151
99regulation of axon extension involved in axon guidance (GO:0048841)2.69463054
100regulation of voltage-gated calcium channel activity (GO:1901385)2.69432972
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68002114
102positive regulation of dendritic spine development (GO:0060999)2.67931079
103response to auditory stimulus (GO:0010996)2.67466149
104positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67359840
105regulation of neurotransmitter transport (GO:0051588)2.65799955
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.65495667
107* synapse organization (GO:0050808)2.63927580
108potassium ion homeostasis (GO:0055075)2.63676048
109organelle transport along microtubule (GO:0072384)2.62899051
110adherens junction assembly (GO:0034333)2.62049335
111negative regulation of dendrite morphogenesis (GO:0050774)2.61425109
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60761393
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60682319
114cell communication involved in cardiac conduction (GO:0086065)2.60343552
115negative regulation of catenin import into nucleus (GO:0035414)2.59645262
116endodermal cell differentiation (GO:0035987)2.59406199
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58869451
118cell communication by electrical coupling (GO:0010644)2.58073237
119* synapse assembly (GO:0007416)2.57754979
120regulation of synaptic transmission (GO:0050804)2.57701166
121* learning (GO:0007612)2.56726958
122behavioral response to cocaine (GO:0048148)2.56325683
123camera-type eye morphogenesis (GO:0048593)2.55569472
124neuron projection extension (GO:1990138)2.50996562
125cerebellar Purkinje cell layer development (GO:0021680)2.50139862
126cellular sodium ion homeostasis (GO:0006883)2.49222835
127myelination in peripheral nervous system (GO:0022011)2.48913482
128peripheral nervous system axon ensheathment (GO:0032292)2.48913482
129desmosome organization (GO:0002934)2.47394779
130cellular response to prostaglandin stimulus (GO:0071379)2.46800098
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.43448190
132axon extension involved in axon guidance (GO:0048846)2.43448190
133surfactant homeostasis (GO:0043129)2.41529521
134cell migration involved in sprouting angiogenesis (GO:0002042)2.40731504
135basement membrane organization (GO:0071711)2.38631668
136peptidyl-tyrosine autophosphorylation (GO:0038083)2.35743760
137insulin-like growth factor receptor signaling pathway (GO:0048009)2.33739794
138asymmetric protein localization (GO:0008105)2.33493133
139regulation of ARF protein signal transduction (GO:0032012)2.33305321
140regulation of early endosome to late endosome transport (GO:2000641)2.33019926
141focal adhesion assembly (GO:0048041)2.31833742
142cell-substrate adherens junction assembly (GO:0007045)2.31833742
143regulation of axon guidance (GO:1902667)2.30645369
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29859433
145Golgi transport vesicle coating (GO:0048200)2.29517440
146COPI coating of Golgi vesicle (GO:0048205)2.29517440
147negative regulation of chondrocyte differentiation (GO:0032331)2.25000473
148cellular response to catecholamine stimulus (GO:0071870)2.23354187
149cellular response to monoamine stimulus (GO:0071868)2.23354187
150positive regulation of axon extension (GO:0045773)2.23302100
151protein targeting to plasma membrane (GO:0072661)2.20888289
152embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20113568
153barbed-end actin filament capping (GO:0051016)2.19407058
154epithelial cell-cell adhesion (GO:0090136)2.19112877
155membrane assembly (GO:0071709)2.18797365
156regulation of establishment of planar polarity (GO:0090175)2.18654083
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.18142200
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.18102506
159paraxial mesoderm development (GO:0048339)2.17870700
160adherens junction organization (GO:0034332)2.17550506
161establishment of planar polarity (GO:0001736)2.16889250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98186929
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.57823958
3GBX2_23144817_ChIP-Seq_PC3_Human3.09558777
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03608558
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99889483
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89489572
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69201566
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69201566
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57202829
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52344791
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51861384
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49766523
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44951499
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44508505
15DROSHA_22980978_ChIP-Seq_HELA_Human2.34872234
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29832976
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.27933069
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26483435
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18429256
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16974167
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.14751414
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13320272
23REST_21632747_ChIP-Seq_MESCs_Mouse2.13032420
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10766265
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09479060
26CLOCK_20551151_ChIP-Seq_293T_Human2.00544036
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99229156
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92883741
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83196001
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.82983208
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82910876
32AR_21572438_ChIP-Seq_LNCaP_Human1.82434380
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.72143651
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70650334
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70337023
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68678003
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64095769
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59461774
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57532789
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56896962
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53891181
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.51858950
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49392079
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49319682
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49295321
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48127650
47* TAF15_26573619_Chip-Seq_HEK293_Human1.46516953
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44931329
49SMAD4_21799915_ChIP-Seq_A2780_Human1.44350471
50* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43922766
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42199267
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41563500
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41016317
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39591304
55* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39087204
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37977954
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37876291
58ZNF263_19887448_ChIP-Seq_K562_Human1.37338625
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35258001
60LXR_22292898_ChIP-Seq_THP-1_Human1.34070428
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33655492
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30979399
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30858222
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30781677
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30298065
66* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29498205
67* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28198751
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27402873
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27320429
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27265299
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26472849
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25970808
73ZNF274_21170338_ChIP-Seq_K562_Hela1.25776515
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.25061727
75* TET1_21490601_ChIP-Seq_MESCs_Mouse1.24499761
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.23515462
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23115069
78* PIAS1_25552417_ChIP-Seq_VCAP_Human1.22886197
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.22675109
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21447156
81AHR_22903824_ChIP-Seq_MCF-7_Human1.20948464
82* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20748976
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.20446291
84P300_19829295_ChIP-Seq_ESCs_Human1.19810334
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19634036
86RACK7_27058665_Chip-Seq_MCF-7_Human1.19246727
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.18920566
88TP53_16413492_ChIP-PET_HCT116_Human1.18324555
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17977937
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.16317747
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.15402120
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14345235
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.13864492
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13738940
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12807620
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.11864131
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11815025
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.11519866
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09358301
100* STAT3_23295773_ChIP-Seq_U87_Human1.09125417
101* AR_25329375_ChIP-Seq_VCAP_Human1.08496136
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08317239
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07808826
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07708459
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06782797
106* AR_19668381_ChIP-Seq_PC3_Human1.06759990
107KDM2B_26808549_Chip-Seq_K562_Human1.06085571
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04908233
109* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04793146
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04618450
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04533384
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04440403
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04437294
114TP53_18474530_ChIP-ChIP_U2OS_Human1.02175089
115* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01317452
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00487819
117* EP300_21415370_ChIP-Seq_HL-1_Mouse0.99832227
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.99366628
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.99366628
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99189996
121KDM2B_26808549_Chip-Seq_DND41_Human0.98820200
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98275381
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97499868
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97018140
125* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97009377
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96394378
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95344812
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95283579
129TCF4_23295773_ChIP-Seq_U87_Human0.94870277
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94824775
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.94675028
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.94120252
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93998009
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93804628
135CTCF_27219007_Chip-Seq_Bcells_Human0.93579453
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92530948
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92509820
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91910347
139NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91659259
140RUNX2_22187159_ChIP-Seq_PCA_Human0.90737526
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90372723
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90372723
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.89789500
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89426435
145RXR_22108803_ChIP-Seq_LS180_Human0.89421068
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89159396
147* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88876874
148ER_23166858_ChIP-Seq_MCF-7_Human0.88619530
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88122703
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.87880795
151* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86164973
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.85749570
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85611723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97137915
2MP0003880_abnormal_central_pattern4.89777624
3* MP0003635_abnormal_synaptic_transmissio3.88926109
4MP0004270_analgesia3.67494239
5MP0003705_abnormal_hypodermis_morpholog3.37739339
6MP0009745_abnormal_behavioral_response3.22375356
7MP0008438_abnormal_cutaneous_collagen3.16534657
8MP0002064_seizures3.13196755
9MP0002063_abnormal_learning/memory/cond3.04289157
10MP0009046_muscle_twitch2.97634264
11MP0000579_abnormal_nail_morphology2.82148800
12MP0002272_abnormal_nervous_system2.64314285
13MP0005257_abnormal_intraocular_pressure2.58698717
14MP0001486_abnormal_startle_reflex2.58241129
15MP0001968_abnormal_touch/_nociception2.55995087
16* MP0002572_abnormal_emotion/affect_behav2.50814229
17MP0005423_abnormal_somatic_nervous2.50020579
18MP0002734_abnormal_mechanical_nocicepti2.44602099
19MP0002877_abnormal_melanocyte_morpholog2.35422485
20MP0001501_abnormal_sleep_pattern2.34899676
21MP0003566_abnormal_cell_adhesion2.25195159
22MP0001440_abnormal_grooming_behavior2.18579866
23MP0010368_abnormal_lymphatic_system2.18070251
24MP0002822_catalepsy2.17845083
25MP0000537_abnormal_urethra_morphology2.10505707
26MP0009780_abnormal_chondrocyte_physiolo2.01241006
27MP0001849_ear_inflammation2.00587813
28MP0002736_abnormal_nociception_after1.93604713
29MP0002733_abnormal_thermal_nociception1.90452217
30MP0000920_abnormal_myelination1.90419193
31MP0004885_abnormal_endolymph1.89527377
32MP0005275_abnormal_skin_tensile1.89011112
33* MP0003329_amyloid_beta_deposits1.88680917
34MP0002735_abnormal_chemical_nociception1.86598291
35MP0002067_abnormal_sensory_capabilities1.85593185
36MP0001970_abnormal_pain_threshold1.83914793
37MP0008569_lethality_at_weaning1.82531036
38* MP0000778_abnormal_nervous_system1.82193417
39MP0004858_abnormal_nervous_system1.78147467
40MP0001958_emphysema1.73483744
41MP0002184_abnormal_innervation1.69489510
42MP0000566_synostosis1.59954876
43MP0004924_abnormal_behavior1.59077227
44MP0005386_behavior/neurological_phenoty1.59077227
45MP0003091_abnormal_cell_migration1.57738188
46MP0000762_abnormal_tongue_morphology1.55207743
47MP0000955_abnormal_spinal_cord1.54946779
48MP0002909_abnormal_adrenal_gland1.54443834
49MP0003690_abnormal_glial_cell1.54380337
50MP0002557_abnormal_social/conspecific_i1.52508763
51MP0004811_abnormal_neuron_physiology1.52131268
52MP0005503_abnormal_tendon_morphology1.51629648
53MP0005623_abnormal_meninges_morphology1.43289299
54MP0003879_abnormal_hair_cell1.43288042
55MP0006276_abnormal_autonomic_nervous1.41205864
56* MP0002066_abnormal_motor_capabilities/c1.41161142
57* MP0002882_abnormal_neuron_morphology1.40152261
58MP0003633_abnormal_nervous_system1.38834983
59MP0001905_abnormal_dopamine_level1.37899563
60MP0003279_aneurysm1.36062859
61MP0004742_abnormal_vestibular_system1.35439901
62MP0002896_abnormal_bone_mineralization1.34427451
63MP0001529_abnormal_vocalization1.33356990
64MP0001879_abnormal_lymphatic_vessel1.28007444
65MP0003941_abnormal_skin_development1.24564799
66MP0004142_abnormal_muscle_tone1.23524926
67MP0002060_abnormal_skin_morphology1.23144717
68* MP0003634_abnormal_glial_cell1.22955529
69MP0000013_abnormal_adipose_tissue1.20295410
70* MP0003631_nervous_system_phenotype1.17157903
71MP0004145_abnormal_muscle_electrophysio1.15172328
72MP0000751_myopathy1.13928115
73MP0002089_abnormal_postnatal_growth/wei1.13480542
74MP0009053_abnormal_anal_canal1.13132427
75MP0001177_atelectasis1.10981248
76MP0002229_neurodegeneration1.10126240
77MP0005645_abnormal_hypothalamus_physiol1.03589947
78MP0010030_abnormal_orbit_morphology1.03228966
79MP0001984_abnormal_olfaction1.03085898
80MP0005076_abnormal_cell_differentiation1.02942838
81* MP0002152_abnormal_brain_morphology1.02482757
82MP0000467_abnormal_esophagus_morphology0.99921875
83MP0003283_abnormal_digestive_organ0.98968114
84MP0003385_abnormal_body_wall0.97750655
85MP0005508_abnormal_skeleton_morphology0.97566188
86MP0003075_altered_response_to0.96783177
87MP0005023_abnormal_wound_healing0.95664292
88MP0001485_abnormal_pinna_reflex0.95531705
89MP0000462_abnormal_digestive_system0.95101490
90MP0010386_abnormal_urinary_bladder0.94874652
91* MP0003632_abnormal_nervous_system0.94444187
92MP0010234_abnormal_vibrissa_follicle0.94130929
93MP0001299_abnormal_eye_distance/0.93698448
94MP0005646_abnormal_pituitary_gland0.93036143
95MP0010352_gastrointestinal_tract_polyps0.92516296
96MP0000678_abnormal_parathyroid_gland0.91753822
97MP0001963_abnormal_hearing_physiology0.90807705
98MP0005167_abnormal_blood-brain_barrier0.89674656
99MP0002090_abnormal_vision0.87979184
100MP0003123_paternal_imprinting0.87636243
101MP0008874_decreased_physiological_sensi0.87524411
102MP0003122_maternal_imprinting0.87445474
103MP0003453_abnormal_keratinocyte_physiol0.87433858
104MP0001915_intracranial_hemorrhage0.86982539
105MP0005409_darkened_coat_color0.85407554
106MP0000428_abnormal_craniofacial_morphol0.85110404
107MP0002069_abnormal_eating/drinking_beha0.83880696
108* MP0000604_amyloidosis0.83855920
109MP0005551_abnormal_eye_electrophysiolog0.83262974
110MP0003942_abnormal_urinary_system0.82701571
111MP0002697_abnormal_eye_size0.81608249
112MP0003115_abnormal_respiratory_system0.80615730
113MP0004043_abnormal_pH_regulation0.80589008
114MP0002837_dystrophic_cardiac_calcinosis0.79328298
115MP0000767_abnormal_smooth_muscle0.78940148
116MP0000733_abnormal_muscle_development0.77376621
117MP0004085_abnormal_heartbeat0.77317900
118* MP0001502_abnormal_circadian_rhythm0.76767186
119MP0003861_abnormal_nervous_system0.76506629
120MP0005248_abnormal_Harderian_gland0.76434404
121MP0002752_abnormal_somatic_nervous0.76299589
122MP0004484_altered_response_of0.75482698
123MP0006138_congestive_heart_failure0.75278514
124MP0005535_abnormal_body_temperature0.75232439
125MP0008872_abnormal_physiological_respon0.74863133
126MP0000747_muscle_weakness0.73061264
127MP0003787_abnormal_imprinting0.72312483
128MP0005595_abnormal_vascular_smooth0.72184004
129MP0002796_impaired_skin_barrier0.71525018
130MP0003935_abnormal_craniofacial_develop0.69846180
131MP0005171_absent_coat_pigmentation0.68977816
132MP0001664_abnormal_digestion0.68674669
133MP0001188_hyperpigmentation0.68057194
134MP0002116_abnormal_craniofacial_bone0.67653378
135MP0009384_cardiac_valve_regurgitation0.67558284
136MP0005197_abnormal_uvea_morphology0.66819986
137MP0008961_abnormal_basal_metabolism0.66387356
138MP0010771_integument_phenotype0.65527498
139MP0002081_perinatal_lethality0.64195788
140MP0003172_abnormal_lysosome_physiology0.64183117
141MP0000432_abnormal_head_morphology0.64101410
142MP0004510_myositis0.63422139
143MP0001943_abnormal_respiration0.62230762
144MP0003045_fibrosis0.61945663
145MP0001348_abnormal_lacrimal_gland0.61617508
146MP0003137_abnormal_impulse_conducting0.59839727
147MP0002295_abnormal_pulmonary_circulatio0.57854787
148MP0000534_abnormal_ureter_morphology0.55805587
149MP0000631_abnormal_neuroendocrine_gland0.55772691
150MP0000003_abnormal_adipose_tissue0.52376142
151MP0004215_abnormal_myocardial_fiber0.51840784
152MP0004272_abnormal_basement_membrane0.51778749

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.38065904
2Myokymia (HP:0002411)5.68513820
3Focal seizures (HP:0007359)5.04720182
4Protrusio acetabuli (HP:0003179)4.64192688
5Visual hallucinations (HP:0002367)4.53583806
6Supranuclear gaze palsy (HP:0000605)4.46704618
7Atrophic scars (HP:0001075)4.41956558
8Atonic seizures (HP:0010819)4.19278666
9Premature rupture of membranes (HP:0001788)4.02759065
10Action tremor (HP:0002345)3.85729241
11Epileptic encephalopathy (HP:0200134)3.85456188
12Progressive cerebellar ataxia (HP:0002073)3.56281837
13Absence seizures (HP:0002121)3.55364665
14Ankle clonus (HP:0011448)3.50710273
15Dialeptic seizures (HP:0011146)3.30777266
16Dysmetria (HP:0001310)3.30307546
17Generalized tonic-clonic seizures (HP:0002069)3.29913842
18Shallow orbits (HP:0000586)3.15828201
19Mutism (HP:0002300)3.10744308
20Broad-based gait (HP:0002136)3.10273954
21Febrile seizures (HP:0002373)3.10071411
22Abnormality of the corticospinal tract (HP:0002492)3.07103791
23Termporal pattern (HP:0011008)3.05520728
24Insidious onset (HP:0003587)3.05520728
25Neonatal short-limb short stature (HP:0008921)3.04309343
26Intention tremor (HP:0002080)2.98779706
27Obstructive sleep apnea (HP:0002870)2.98587944
28* Neurofibrillary tangles (HP:0002185)2.98449915
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.93807886
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93807886
31* Cerebral inclusion bodies (HP:0100314)2.92485061
32Dysdiadochokinesis (HP:0002075)2.92320785
33Cerebral aneurysm (HP:0004944)2.85634788
34Hyperacusis (HP:0010780)2.83554964
35Fragile skin (HP:0001030)2.81680449
36Scanning speech (HP:0002168)2.80971275
37Spastic gait (HP:0002064)2.79829383
38Depression (HP:0000716)2.78860535
39Bladder diverticulum (HP:0000015)2.74488895
40Anxiety (HP:0000739)2.70471481
41Poor eye contact (HP:0000817)2.69749745
42Gaze-evoked nystagmus (HP:0000640)2.69004101
43Abnormal eating behavior (HP:0100738)2.68873667
44Truncal ataxia (HP:0002078)2.67333192
45Urinary bladder sphincter dysfunction (HP:0002839)2.65908935
46Postural instability (HP:0002172)2.62517335
47Hyperventilation (HP:0002883)2.61843875
48Papilledema (HP:0001085)2.57637390
49Urinary urgency (HP:0000012)2.55436575
50Impaired social interactions (HP:0000735)2.53415493
51Abnormal social behavior (HP:0012433)2.53415493
52Impaired vibration sensation in the lower limbs (HP:0002166)2.53215686
53Vertebral arch anomaly (HP:0008438)2.52974594
54Amblyopia (HP:0000646)2.51040440
55Progressive inability to walk (HP:0002505)2.49785731
56Abnormality of binocular vision (HP:0011514)2.48008596
57Diplopia (HP:0000651)2.48008596
58Turricephaly (HP:0000262)2.46797448
59Abnormality of dentin (HP:0010299)2.46454613
60Wormian bones (HP:0002645)2.45256658
61Hemiparesis (HP:0001269)2.45208657
62Aortic dissection (HP:0002647)2.44864268
63Excessive salivation (HP:0003781)2.40666207
64Drooling (HP:0002307)2.40666207
65Megalencephaly (HP:0001355)2.39949779
66Lower limb muscle weakness (HP:0007340)2.36846654
67Neuronal loss in central nervous system (HP:0002529)2.36462541
68Genu recurvatum (HP:0002816)2.33858289
69Torticollis (HP:0000473)2.33815320
70Peripheral hypomyelination (HP:0007182)2.33140919
71Broad metatarsal (HP:0001783)2.32753980
72Ulnar bowing (HP:0003031)2.29994138
73Limb dystonia (HP:0002451)2.29530324
74Rapidly progressive (HP:0003678)2.27004054
75Aplasia involving bones of the upper limbs (HP:0009823)2.26273851
76Aplasia of the phalanges of the hand (HP:0009802)2.26273851
77Aplasia involving bones of the extremities (HP:0009825)2.26273851
78Pheochromocytoma (HP:0002666)2.26215712
79Distal upper limb amyotrophy (HP:0007149)2.23523258
80Upper limb amyotrophy (HP:0009129)2.23523258
81Hemiplegia (HP:0002301)2.23318483
82Genetic anticipation (HP:0003743)2.19998304
83Mild short stature (HP:0003502)2.18822504
84Mitral valve prolapse (HP:0001634)2.17239370
85Increased circulating renin level (HP:0000848)2.16511805
86Onion bulb formation (HP:0003383)2.11001620
87Hyperextensible skin (HP:0000974)2.09818297
88Generalized myoclonic seizures (HP:0002123)2.08933870
89Absent speech (HP:0001344)2.08663645
90Bowel diverticulosis (HP:0005222)2.07008828
91Stereotypic behavior (HP:0000733)2.06776733
92Akinesia (HP:0002304)2.06301697
93Mitral regurgitation (HP:0001653)2.05931276
94Ankyloglossia (HP:0010296)2.04698655
95Focal dystonia (HP:0004373)2.04040423
96Overgrowth (HP:0001548)2.03803140
97* Vascular tortuosity (HP:0004948)2.03677248
98Milia (HP:0001056)2.02904858
99Soft skin (HP:0000977)2.01692995
100Abnormality of the lower motor neuron (HP:0002366)2.01526379
101Bradykinesia (HP:0002067)2.00892202
102Hand muscle atrophy (HP:0009130)1.99622381
103Ankle contracture (HP:0006466)1.95014090
104Retinal dysplasia (HP:0007973)1.94352348
105Fetal akinesia sequence (HP:0001989)1.93796461
106Spinal rigidity (HP:0003306)1.92937095
107Ventricular fibrillation (HP:0001663)1.91086208
108Epileptiform EEG discharges (HP:0011182)1.91016316
109Coronal craniosynostosis (HP:0004440)1.90291238
110Clumsiness (HP:0002312)1.89189004
111Buphthalmos (HP:0000557)1.89121876
112Cervical subluxation (HP:0003308)1.88676039
113Polyphagia (HP:0002591)1.88523786
114Craniofacial dystonia (HP:0012179)1.87470287
115Neuroendocrine neoplasm (HP:0100634)1.87356629
116Broad face (HP:0000283)1.87263104
117Thickened helices (HP:0000391)1.87225351
118Bronchomalacia (HP:0002780)1.87131009
119Hypoplasia of the iris (HP:0007676)1.87130910
120Impaired smooth pursuit (HP:0007772)1.86853648
121* Arterial tortuosity (HP:0005116)1.86850289
122Wide anterior fontanel (HP:0000260)1.86663037
123EEG with generalized epileptiform discharges (HP:0011198)1.85659745
124Overriding aorta (HP:0002623)1.85006153
125Clonus (HP:0002169)1.84484374
126Agitation (HP:0000713)1.84284588
127Psychosis (HP:0000709)1.82420755
128Lower limb amyotrophy (HP:0007210)1.82360001
129Insomnia (HP:0100785)1.81392435
130Rigidity (HP:0002063)1.81248758
131Gait ataxia (HP:0002066)1.81226686
132Fragile nails (HP:0001808)1.80889793
133Morphological abnormality of the middle ear (HP:0008609)1.80274708
134Apathy (HP:0000741)1.79974725
135Arnold-Chiari malformation (HP:0002308)1.79726055
136Back pain (HP:0003418)1.79379054
137Status epilepticus (HP:0002133)1.78288440
138Vertebral compression fractures (HP:0002953)1.76387979
139Renal duplication (HP:0000075)1.76338713
140Abnormality of salivation (HP:0100755)1.75856610
141Metabolic alkalosis (HP:0200114)1.75646126
142Postural tremor (HP:0002174)1.75021153
143Elfin facies (HP:0004428)1.74914558
144Hypsarrhythmia (HP:0002521)1.74145748
145Hypoventilation (HP:0002791)1.73317065
146Abnormality of saccadic eye movements (HP:0000570)1.72728803
147Aortic aneurysm (HP:0004942)1.72075360
148Hammertoe (HP:0001765)1.71213775
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70241214
150Blue sclerae (HP:0000592)1.70098048
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69966458
152Nuclear cataract (HP:0100018)1.69264934
153Biconcave vertebral bodies (HP:0004586)1.69154566
154Spinal cord compression (HP:0002176)1.66325409
155Pterygium (HP:0001059)1.65352259
156Short nail (HP:0001799)1.64865249
157Renovascular hypertension (HP:0100817)1.64414288
158Pointed chin (HP:0000307)1.63696113
159Abnormality of oral frenula (HP:0000190)1.63275889
160Aneurysm (HP:0002617)1.62541321
161Mildly elevated creatine phosphokinase (HP:0008180)1.59809294
162Advanced eruption of teeth (HP:0006288)1.59610659
163Tibial bowing (HP:0002982)1.58577218
164Osteoarthritis (HP:0002758)1.57589353
165Right ventricular cardiomyopathy (HP:0011663)1.57112214
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.56363507
167Increased variability in muscle fiber diameter (HP:0003557)1.56174018
168Natal tooth (HP:0000695)1.55811343
169Joint laxity (HP:0001388)1.55598702
170Difficulty climbing stairs (HP:0003551)1.54487775
171Achilles tendon contracture (HP:0001771)1.53621542
172Distal lower limb amyotrophy (HP:0008944)1.52603019
173Diminished motivation (HP:0000745)1.52259713
174Breech presentation (HP:0001623)1.50643269
175Dilatation of the ascending aorta (HP:0005111)1.50606730
176Flat acetabular roof (HP:0003180)1.50193702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.95969257
2NTRK33.64804444
3MAP3K93.57866183
4MARK12.56327594
5TRIB32.46276419
6MAP3K42.45571450
7PAK62.36556478
8MINK12.31073206
9STK392.29803264
10KSR22.24173768
11DAPK22.22292670
12RIPK42.21353518
13EPHB22.12465366
14OXSR12.12155363
15PNCK1.99180533
16EPHA21.87625372
17* NTRK11.86010555
18CDK121.81341187
19SIK11.78382405
20MET1.76278490
21MAP2K71.74279315
22NTRK21.73239788
23PRKD31.63383231
24MAP2K41.55589949
25EEF2K1.51614390
26MST1R1.51553124
27CAMKK11.50352996
28* CDK51.47360332
29TYRO31.47142593
30ARAF1.41104689
31WNK41.38833456
32CDK191.37993165
33MAP3K121.36765053
34TNIK1.35947081
35PLK21.34157605
36MAP3K131.33679819
37MAP3K21.30000583
38GRK51.27940524
39KSR11.27625204
40UHMK11.27530492
41TIE11.26532707
42FES1.24991938
43CASK1.20428639
44PAK31.20309319
45PKN21.15546270
46CAMK2B1.15054336
47WNK11.14733690
48TTN1.13459211
49FGFR41.13086253
50SIK21.11837009
51CAMK2A1.09890176
52LATS11.07277856
53PTK2B1.06320708
54PDGFRB1.05631807
55TESK11.04339221
56STK381.01855522
57RET1.00827406
58FGR1.00340991
59SMG11.00064899
60PAK20.99404206
61PRKCG0.97877529
62CDK140.97102811
63LATS20.96838797
64FGFR20.95502275
65DDR20.94359755
66CSNK1G20.93487399
67MTOR0.92389047
68PRKCH0.92323536
69CAMKK20.92151549
70CDK150.92028168
71SGK4940.91956449
72SGK2230.91956449
73MAPKAPK50.91840163
74PHKG20.91637223
75PHKG10.91637223
76PRPF4B0.90416084
77STK110.89963635
78RPS6KA20.89584941
79CDK180.89462805
80CAMK1G0.89450909
81MAPK130.88883647
82PKN10.88755661
83CAMK2D0.88621074
84DAPK10.86290513
85SGK30.82939389
86FER0.82170483
87PAK40.80197429
88CDK11A0.79152964
89BCR0.77609298
90BMPR20.76657333
91PDPK10.75868055
92MARK20.75630466
93PRKCE0.71635063
94CAMK10.71620689
95RIPK10.70473395
96EPHB10.69408536
97CAMK2G0.69003503
98DMPK0.67210056
99MAP3K10.66303101
100SGK10.64711044
101RAF10.63827714
102ERBB40.63392090
103LMTK20.62316234
104BMX0.62108962
105ROCK10.61845328
106CAMK1D0.60152376
107DYRK1A0.59536813
108PTK60.59533974
109NEK60.58955185
110PDK10.58249136
111SCYL20.57752439
112ALK0.56661276
113* FYN0.56448100
114* MAPK100.54719875
115LIMK10.54018554
116SGK20.54013552
117WNK30.53853048
118TAOK10.53754518
119ICK0.52418017
120CSNK1G30.52301815
121MAP2K10.51356069
122CDC42BPA0.51083525
123* ROCK20.51038195
124PRKCZ0.50953592
125ERBB20.48643181
126PTK20.47960433
127ERN10.46904903
128DAPK30.46851493
129PINK10.46446520
130BRAF0.45827769
131CSNK1A1L0.43644723
132* SRC0.42167214
133PDGFRA0.41923253
134MOS0.41801541
135RPS6KA30.41571402
136PRKG20.39659159
137MAP3K60.39555014

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11660933
2Synaptic vesicle cycle_Homo sapiens_hsa047212.80682364
3GABAergic synapse_Homo sapiens_hsa047272.46645418
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40176780
5Glutamatergic synapse_Homo sapiens_hsa047242.35076487
6Long-term potentiation_Homo sapiens_hsa047202.32537451
7Circadian entrainment_Homo sapiens_hsa047132.32005580
8Morphine addiction_Homo sapiens_hsa050322.19150133
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18908813
10Salivary secretion_Homo sapiens_hsa049702.13531999
11Olfactory transduction_Homo sapiens_hsa047402.12786315
12Amphetamine addiction_Homo sapiens_hsa050312.09975360
13Gastric acid secretion_Homo sapiens_hsa049711.94471683
14Dopaminergic synapse_Homo sapiens_hsa047281.92926658
15Long-term depression_Homo sapiens_hsa047301.73051797
16Cholinergic synapse_Homo sapiens_hsa047251.71128807
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69672908
18Renin secretion_Homo sapiens_hsa049241.69134048
19Insulin secretion_Homo sapiens_hsa049111.67239175
20Taste transduction_Homo sapiens_hsa047421.60756456
21Cocaine addiction_Homo sapiens_hsa050301.57885615
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57156667
23Adherens junction_Homo sapiens_hsa045201.57080886
24* Serotonergic synapse_Homo sapiens_hsa047261.54363748
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53501786
26Collecting duct acid secretion_Homo sapiens_hsa049661.51621575
27Oxytocin signaling pathway_Homo sapiens_hsa049211.50550146
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48218970
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44406705
30Axon guidance_Homo sapiens_hsa043601.43086714
31GnRH signaling pathway_Homo sapiens_hsa049121.36887984
32Calcium signaling pathway_Homo sapiens_hsa040201.36764130
33Gap junction_Homo sapiens_hsa045401.33405402
34Protein digestion and absorption_Homo sapiens_hsa049741.23657887
35Proteoglycans in cancer_Homo sapiens_hsa052051.19816175
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18903811
37cAMP signaling pathway_Homo sapiens_hsa040241.18167957
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.18153178
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15946305
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15839320
41Estrogen signaling pathway_Homo sapiens_hsa049151.14941738
42Endometrial cancer_Homo sapiens_hsa052131.12624498
43Hippo signaling pathway_Homo sapiens_hsa043901.11737606
44Vibrio cholerae infection_Homo sapiens_hsa051101.08220710
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07905036
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05850315
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04189976
48Notch signaling pathway_Homo sapiens_hsa043301.03657809
49Glioma_Homo sapiens_hsa052141.02879053
50Melanogenesis_Homo sapiens_hsa049161.02684412
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.01461971
52Pancreatic secretion_Homo sapiens_hsa049721.01001808
53Dorso-ventral axis formation_Homo sapiens_hsa043201.00097900
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99072994
55Chronic myeloid leukemia_Homo sapiens_hsa052200.98560795
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97568517
57ErbB signaling pathway_Homo sapiens_hsa040120.97135633
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.96785098
59Type II diabetes mellitus_Homo sapiens_hsa049300.95804032
60Cardiac muscle contraction_Homo sapiens_hsa042600.92919564
61Nitrogen metabolism_Homo sapiens_hsa009100.90317565
62Thyroid hormone synthesis_Homo sapiens_hsa049180.89576806
63Small cell lung cancer_Homo sapiens_hsa052220.87958887
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87802318
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87736752
66Dilated cardiomyopathy_Homo sapiens_hsa054140.86512971
67MicroRNAs in cancer_Homo sapiens_hsa052060.83770680
68Bladder cancer_Homo sapiens_hsa052190.83308908
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82389089
70Thyroid cancer_Homo sapiens_hsa052160.82206217
71Insulin signaling pathway_Homo sapiens_hsa049100.77910618
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76743414
73Choline metabolism in cancer_Homo sapiens_hsa052310.76511472
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.73710377
75Pancreatic cancer_Homo sapiens_hsa052120.73643629
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.72165425
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72162605
78Renal cell carcinoma_Homo sapiens_hsa052110.71932774
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.71810280
80Basal cell carcinoma_Homo sapiens_hsa052170.71456408
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70321051
82Vitamin B6 metabolism_Homo sapiens_hsa007500.69732714
83VEGF signaling pathway_Homo sapiens_hsa043700.69510834
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67577445
85Endocytosis_Homo sapiens_hsa041440.66548007
86MAPK signaling pathway_Homo sapiens_hsa040100.65820643
87Hedgehog signaling pathway_Homo sapiens_hsa043400.65638964
88Ras signaling pathway_Homo sapiens_hsa040140.65508599
89mTOR signaling pathway_Homo sapiens_hsa041500.65376314
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64847080
91Pathways in cancer_Homo sapiens_hsa052000.64769034
92Rap1 signaling pathway_Homo sapiens_hsa040150.64678885
93AMPK signaling pathway_Homo sapiens_hsa041520.64188643
94Glucagon signaling pathway_Homo sapiens_hsa049220.61576742
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61278425
96Colorectal cancer_Homo sapiens_hsa052100.61052417
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59941560
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59905846
99Bile secretion_Homo sapiens_hsa049760.57258929
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55342573
101Oocyte meiosis_Homo sapiens_hsa041140.54120734
102Phototransduction_Homo sapiens_hsa047440.53856112
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51863088
104Tight junction_Homo sapiens_hsa045300.51499364
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.51249130
106Prion diseases_Homo sapiens_hsa050200.50989179
107Mineral absorption_Homo sapiens_hsa049780.50890143
108Inositol phosphate metabolism_Homo sapiens_hsa005620.49068529
109Ovarian steroidogenesis_Homo sapiens_hsa049130.48591409
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48007058
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46670202
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46020147
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44460294
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43853362
115Wnt signaling pathway_Homo sapiens_hsa043100.43234344
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42934178
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42236653
118Ether lipid metabolism_Homo sapiens_hsa005650.41829813
119Alzheimers disease_Homo sapiens_hsa050100.41549574
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40939538
121Rheumatoid arthritis_Homo sapiens_hsa053230.40886073
122Amoebiasis_Homo sapiens_hsa051460.40719661
123Focal adhesion_Homo sapiens_hsa045100.39932712
124ECM-receptor interaction_Homo sapiens_hsa045120.39215808
125African trypanosomiasis_Homo sapiens_hsa051430.38303944
126Chemokine signaling pathway_Homo sapiens_hsa040620.36561536
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35808395
128Platelet activation_Homo sapiens_hsa046110.35469891
129Lysosome_Homo sapiens_hsa041420.32426464
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32173180
131Phagosome_Homo sapiens_hsa041450.31948564

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