APPBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)6.19992047
2axon ensheathment in central nervous system (GO:0032291)5.16854179
3central nervous system myelination (GO:0022010)5.16854179
4regulation of centriole replication (GO:0046599)5.14029347
5regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.65849901
6vagina development (GO:0060068)4.42756938
7intestinal epithelial cell development (GO:0060576)4.19010645
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.16790772
9regulation of establishment of cell polarity (GO:2000114)4.07980562
10embryonic camera-type eye morphogenesis (GO:0048596)4.05189528
11ear development (GO:0043583)4.03702523
12striated muscle atrophy (GO:0014891)3.99145450
13cardiac right ventricle morphogenesis (GO:0003215)3.96214759
14positive regulation of keratinocyte differentiation (GO:0045618)3.89049329
15regulation of establishment or maintenance of cell polarity (GO:0032878)3.88927334
16regulation of cell proliferation involved in kidney development (GO:1901722)3.79831065
17female genitalia development (GO:0030540)3.72938398
18skeletal muscle adaptation (GO:0043501)3.47910169
19negative regulation of neurotransmitter secretion (GO:0046929)3.45257272
20myelination (GO:0042552)3.41774312
21neuron cell-cell adhesion (GO:0007158)3.39945212
22ensheathment of neurons (GO:0007272)3.36921383
23axon ensheathment (GO:0008366)3.36921383
24muscle atrophy (GO:0014889)3.36157978
25negative regulation of neurotransmitter transport (GO:0051589)3.35034384
26negative regulation of organelle assembly (GO:1902116)3.31040074
27apical protein localization (GO:0045176)3.28834158
28neural tube formation (GO:0001841)3.28484141
29regulation of centrosome duplication (GO:0010824)3.27679645
30regulation of fatty acid beta-oxidation (GO:0031998)3.25521636
31limb bud formation (GO:0060174)3.24052328
32uterus development (GO:0060065)3.21941052
33regulation of axon extension involved in axon guidance (GO:0048841)3.20357168
34presynaptic membrane assembly (GO:0097105)3.19071103
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.17361719
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.12160774
37regulation of axon guidance (GO:1902667)3.11185441
38ectodermal placode formation (GO:0060788)3.11151244
39norepinephrine metabolic process (GO:0042415)3.09429739
40mesonephros development (GO:0001823)3.09173910
41establishment of mitochondrion localization (GO:0051654)3.08920527
42cerebral cortex radially oriented cell migration (GO:0021799)3.07734746
43asymmetric protein localization (GO:0008105)3.07276414
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.04106284
45embryonic eye morphogenesis (GO:0048048)3.00837216
46TOR signaling (GO:0031929)3.00687049
47presynaptic membrane organization (GO:0097090)3.00010605
48sympathetic nervous system development (GO:0048485)2.96073356
49peptidyl-threonine dephosphorylation (GO:0035970)2.93875540
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.93425191
51prostate gland growth (GO:0060736)2.90210982
52cerebellar granule cell differentiation (GO:0021707)2.89480474
53long-chain fatty acid biosynthetic process (GO:0042759)2.89257770
54insulin-like growth factor receptor signaling pathway (GO:0048009)2.87980602
55axonal fasciculation (GO:0007413)2.78422143
56neuron recognition (GO:0008038)2.77585200
57epithelial cell maturation (GO:0002070)2.75719292
58regulation of synaptic vesicle exocytosis (GO:2000300)2.75409312
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75371015
60regulation of RNA export from nucleus (GO:0046831)2.68923175
61ER overload response (GO:0006983)2.67940819
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66028048
63negative regulation of axon guidance (GO:1902668)2.65879851
64photoreceptor cell differentiation (GO:0046530)2.64686145
65eye photoreceptor cell differentiation (GO:0001754)2.64686145
66innervation (GO:0060384)2.64228169
67dendritic spine morphogenesis (GO:0060997)2.63267176
68embryonic epithelial tube formation (GO:0001838)2.60085120
69intra-S DNA damage checkpoint (GO:0031573)2.59228102
70epithelial tube branching involved in lung morphogenesis (GO:0060441)2.58560372
71astrocyte development (GO:0014002)2.57909665
72layer formation in cerebral cortex (GO:0021819)2.57534679
73regulation of centrosome cycle (GO:0046605)2.55936092
74regulation of meiosis I (GO:0060631)2.54843831
75fatty acid elongation (GO:0030497)2.54016966
76piRNA metabolic process (GO:0034587)2.51675940
77negative regulation of kidney development (GO:0090185)2.49692508
78positive regulation of skeletal muscle tissue development (GO:0048643)2.49571734
79cell differentiation involved in embryonic placenta development (GO:0060706)2.48593541
80Golgi to endosome transport (GO:0006895)2.48286523
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48078030
82cell proliferation involved in metanephros development (GO:0072203)2.47691272
83positive regulation of glycogen biosynthetic process (GO:0045725)2.47499225
84embryonic foregut morphogenesis (GO:0048617)2.46957218
85positive regulation of epidermal cell differentiation (GO:0045606)2.46878778
86branching involved in mammary gland duct morphogenesis (GO:0060444)2.46841519
87microtubule polymerization or depolymerization (GO:0031109)2.46764297
88cochlea development (GO:0090102)2.46677782
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46156336
90regulation of Rac protein signal transduction (GO:0035020)2.45021022
91positive regulation of meiosis (GO:0045836)2.44299856
92post-embryonic morphogenesis (GO:0009886)2.43336279
93transmission of nerve impulse (GO:0019226)2.43287287
94synaptic vesicle exocytosis (GO:0016079)2.42957766
95negative regulation of embryonic development (GO:0045992)2.40993827
96cellular zinc ion homeostasis (GO:0006882)2.40356947
97epithelial tube formation (GO:0072175)2.37334410
98neuronal action potential propagation (GO:0019227)2.37330177
99peptidyl-arginine omega-N-methylation (GO:0035247)2.37148460
100positive regulation of fatty acid oxidation (GO:0046321)2.36965830
101positive regulation of smooth muscle cell migration (GO:0014911)2.35781913
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34953874
103dendrite development (GO:0016358)2.33664621
104synapse assembly (GO:0007416)2.33081078
105positive regulation of oligodendrocyte differentiation (GO:0048714)2.32718386
106regulation of keratinocyte differentiation (GO:0045616)2.32485582
107peptidyl-arginine N-methylation (GO:0035246)2.31757399
108peptidyl-arginine methylation (GO:0018216)2.31757399
109positive regulation of meiotic cell cycle (GO:0051446)2.30161144
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29907258
111negative regulation of axon extension (GO:0030517)2.28711103
112regulation of nucleobase-containing compound transport (GO:0032239)2.27348855
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.26078086
114cardiac ventricle morphogenesis (GO:0003208)2.25702687
115regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25294244
116positive regulation of translational initiation (GO:0045948)2.25207724
117DNA methylation involved in gamete generation (GO:0043046)2.25204369
118mesenchyme morphogenesis (GO:0072132)2.25100326
119regulation of mRNA 3-end processing (GO:0031440)2.25038707
120negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.24295831
121positive regulation of synapse assembly (GO:0051965)2.23040534
122pyrimidine nucleobase catabolic process (GO:0006208)2.22711098
123oligodendrocyte differentiation (GO:0048709)2.22682448
124positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22501542
125synaptic transmission, glutamatergic (GO:0035249)2.22293076
126regulation of collateral sprouting (GO:0048670)2.21716144
127synaptic vesicle maturation (GO:0016188)2.21173066
128central nervous system neuron axonogenesis (GO:0021955)2.20778304
129mitochondrion transport along microtubule (GO:0047497)2.20659446
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.20659446
131histone H2B ubiquitination (GO:0033523)2.19951215
132dendrite morphogenesis (GO:0048813)2.19789092
133negative regulation of axonogenesis (GO:0050771)2.19584183
134polarized epithelial cell differentiation (GO:0030859)2.19467581
135protein localization to synapse (GO:0035418)2.17769438
136neuron-neuron synaptic transmission (GO:0007270)2.16888260
137neurotransmitter catabolic process (GO:0042135)2.16580937
138branching involved in prostate gland morphogenesis (GO:0060442)2.15816597
139nerve growth factor signaling pathway (GO:0038180)2.15426773
140biotin metabolic process (GO:0006768)2.15154473
141negative regulation of Ras GTPase activity (GO:0034261)2.15025075
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.14706540
143positive regulation of glycogen metabolic process (GO:0070875)2.13921019
144zinc ion transmembrane transport (GO:0071577)2.13884527
145myelin maintenance (GO:0043217)2.13534886
146glomerular basement membrane development (GO:0032836)2.13356060
147glutamate secretion (GO:0014047)2.13071630
148neuron maturation (GO:0042551)2.12054699
149cell migration in hindbrain (GO:0021535)2.11840591
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.11283116
151regulation of synaptic vesicle transport (GO:1902803)2.11017760
152lateral sprouting from an epithelium (GO:0060601)2.10574528
153substantia nigra development (GO:0021762)2.09789212
154ionotropic glutamate receptor signaling pathway (GO:0035235)2.09662541
155locomotory exploration behavior (GO:0035641)2.08255026
156gamma-aminobutyric acid signaling pathway (GO:0007214)2.08176347
157central nervous system projection neuron axonogenesis (GO:0021952)2.06832347
158regulation of dendritic spine morphogenesis (GO:0061001)2.06069204
159mRNA splice site selection (GO:0006376)2.05178140
160chondrocyte development (GO:0002063)2.05145167
161cytoplasmic mRNA processing body assembly (GO:0033962)2.02782645
162myelination in peripheral nervous system (GO:0022011)2.01711953
163peripheral nervous system axon ensheathment (GO:0032292)2.01711953
164gonadal mesoderm development (GO:0007506)2.01593335
165positive regulation of mRNA 3-end processing (GO:0031442)2.00562784
166magnesium ion transport (GO:0015693)2.00541616
167cell differentiation in hindbrain (GO:0021533)2.00375709
168positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.00234350
169regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.00234350
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.00161845
171postsynaptic membrane organization (GO:0001941)2.00143038
172regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.99775801
173organelle transport along microtubule (GO:0072384)1.99320292
174nuclear pore complex assembly (GO:0051292)1.99226304
175establishment of nucleus localization (GO:0040023)1.98901406
176positive regulation of mRNA processing (GO:0050685)1.98499790
177glycerophospholipid catabolic process (GO:0046475)1.98165120
178regulation of respiratory system process (GO:0044065)1.96876057
179negative regulation of translation, ncRNA-mediated (GO:0040033)1.96584045
180regulation of translation, ncRNA-mediated (GO:0045974)1.96584045
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.96584045
182nuclear pore organization (GO:0006999)1.95048526
183mechanosensory behavior (GO:0007638)1.94653557
184regulation of dendrite morphogenesis (GO:0048814)1.94524393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human4.66531377
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.54093136
3ZNF217_24962896_ChIP-Seq_MCF-7_Human3.76933061
4EZH2_22144423_ChIP-Seq_EOC_Human3.51105733
5AHR_22903824_ChIP-Seq_MCF-7_Human3.49914510
6GBX2_23144817_ChIP-Seq_PC3_Human3.27812782
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.11431917
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.96265944
9ARNT_22903824_ChIP-Seq_MCF-7_Human2.94356009
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63053836
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51807718
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47491445
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44673648
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.40427510
15FUS_26573619_Chip-Seq_HEK293_Human2.34728906
16FOXM1_26456572_ChIP-Seq_MCF-7_Human2.34405067
17* SALL1_21062744_ChIP-ChIP_HESCs_Human2.21075781
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15139665
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08624105
20* PKCTHETA_26484144_Chip-Seq_BREAST_Human2.05479281
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99807684
22IGF1R_20145208_ChIP-Seq_DFB_Human1.99052995
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97074732
24TAF15_26573619_Chip-Seq_HEK293_Human1.95619238
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.95524925
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.95010225
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91733179
28* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86466736
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85829758
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83848214
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81931969
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81804446
33RNF2_27304074_Chip-Seq_NSC_Mouse1.78946768
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.77444181
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.76715365
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74422100
37AR_21572438_ChIP-Seq_LNCaP_Human1.73145186
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73121963
39EWS_26573619_Chip-Seq_HEK293_Human1.72786374
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71293463
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.69735459
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68704225
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68319813
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67052738
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64127225
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.61372654
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.60788943
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60500550
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60459095
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60354647
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.59050338
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.57220894
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56464616
54P300_19829295_ChIP-Seq_ESCs_Human1.53259798
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.52836433
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50539233
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50271967
58* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48329223
59* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48329223
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48314665
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43248619
62ER_23166858_ChIP-Seq_MCF-7_Human1.42616896
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38761637
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38367492
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38183954
66* STAT3_23295773_ChIP-Seq_U87_Human1.37484887
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36204251
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33164359
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.32882496
70ZNF274_21170338_ChIP-Seq_K562_Hela1.31327095
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30411401
72SMAD4_21799915_ChIP-Seq_A2780_Human1.29785266
73* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29181844
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28427762
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26114143
76REST_21632747_ChIP-Seq_MESCs_Mouse1.26035542
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25857176
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.22982951
79SOX9_26525672_Chip-Seq_HEART_Mouse1.22928202
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.22577890
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21573934
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.21122540
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20013369
84TCF4_23295773_ChIP-Seq_U87_Human1.17683648
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16719840
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16355488
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16065715
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15190144
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.13684129
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.13336657
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.13234105
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11671471
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11558616
94TP53_16413492_ChIP-PET_HCT116_Human1.10993350
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10864856
96VDR_22108803_ChIP-Seq_LS180_Human1.10492745
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.10424157
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10206840
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09730964
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08088526
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07841952
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.06771666
103AR_25329375_ChIP-Seq_VCAP_Human1.05673936
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05420110
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04596573
106BCAT_22108803_ChIP-Seq_LS180_Human1.04127536
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.04058863
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03114544
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02732486
110* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02732486
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02525929
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.02423788
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02238511
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02158142
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02158142
116RUNX2_22187159_ChIP-Seq_PCA_Human1.02096331
117E2F7_22180533_ChIP-Seq_HELA_Human1.00846869
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00109984
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00109984
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00109984
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99570955
122IRF1_19129219_ChIP-ChIP_H3396_Human0.99279368
123* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98668455
124TP53_18474530_ChIP-ChIP_U2OS_Human0.97674878
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97526391
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.96398838
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96278716
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95907988
129POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95689272
130POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.94733780
131* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94608014
132* AR_19668381_ChIP-Seq_PC3_Human0.94281757
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93936048
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92439538
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.89054819
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88493093
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87862022
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.87596325
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85238463
140P53_22387025_ChIP-Seq_ESCs_Mouse0.84992503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu2.87551528
2MP0003123_paternal_imprinting2.85702187
3MP0003122_maternal_imprinting2.82014495
4MP0000383_abnormal_hair_follicle2.81509716
5MP0003121_genomic_imprinting2.66277686
6MP0008877_abnormal_DNA_methylation2.62279462
7MP0003880_abnormal_central_pattern2.60107419
8MP0003787_abnormal_imprinting2.56555362
9MP0004859_abnormal_synaptic_plasticity2.47005098
10MP0004270_analgesia2.38984771
11MP0000427_abnormal_hair_cycle2.17398596
12MP0000778_abnormal_nervous_system2.12969341
13MP0002009_preneoplasia2.05270820
14MP0009384_cardiac_valve_regurgitation1.99350953
15MP0005646_abnormal_pituitary_gland1.96934685
16MP0008057_abnormal_DNA_replication1.93014754
17MP0005623_abnormal_meninges_morphology1.87451994
18MP0003635_abnormal_synaptic_transmissio1.84119066
19MP0004885_abnormal_endolymph1.83861592
20MP0000534_abnormal_ureter_morphology1.78432407
21MP0003183_abnormal_peptide_metabolism1.77869286
22MP0005248_abnormal_Harderian_gland1.75528814
23MP0004134_abnormal_chest_morphology1.75252978
24MP0005076_abnormal_cell_differentiation1.74049685
25MP0002909_abnormal_adrenal_gland1.69789761
26MP0005171_absent_coat_pigmentation1.69489127
27MP0001485_abnormal_pinna_reflex1.66652070
28MP0000920_abnormal_myelination1.65415671
29MP0003942_abnormal_urinary_system1.64235047
30MP0000566_synostosis1.62683849
31MP0009046_muscle_twitch1.61663613
32MP0001486_abnormal_startle_reflex1.60894381
33MP0004233_abnormal_muscle_weight1.59266897
34MP0002736_abnormal_nociception_after1.58758185
35MP0002064_seizures1.57441574
36MP0002272_abnormal_nervous_system1.53265813
37MP0000538_abnormal_urinary_bladder1.53165390
38MP0002063_abnormal_learning/memory/cond1.52751505
39MP0002822_catalepsy1.50945492
40MP0005423_abnormal_somatic_nervous1.50754967
41MP0004742_abnormal_vestibular_system1.48163691
42MP0001299_abnormal_eye_distance/1.48012505
43MP0003937_abnormal_limbs/digits/tail_de1.46583072
44MP0001529_abnormal_vocalization1.45461218
45MP0009745_abnormal_behavioral_response1.43630403
46MP0002734_abnormal_mechanical_nocicepti1.43564132
47MP0002572_abnormal_emotion/affect_behav1.37556266
48MP0009780_abnormal_chondrocyte_physiolo1.36801444
49MP0002098_abnormal_vibrissa_morphology1.36664788
50MP0000955_abnormal_spinal_cord1.35702155
51MP0005187_abnormal_penis_morphology1.32647966
52MP0000631_abnormal_neuroendocrine_gland1.32076090
53MP0000569_abnormal_digit_pigmentation1.30688322
54MP0004381_abnormal_hair_follicle1.29952694
55MP0001440_abnormal_grooming_behavior1.29643231
56MP0002938_white_spotting1.27241120
57MP0002160_abnormal_reproductive_system1.25326643
58MP0003861_abnormal_nervous_system1.24396214
59MP0002184_abnormal_innervation1.23651510
60MP0003136_yellow_coat_color1.23278767
61MP0005409_darkened_coat_color1.22461033
62MP0003890_abnormal_embryonic-extraembry1.20802007
63MP0003119_abnormal_digestive_system1.18911092
64MP0006072_abnormal_retinal_apoptosis1.17120443
65MP0005408_hypopigmentation1.16264861
66MP0002882_abnormal_neuron_morphology1.15435498
67MP0001188_hyperpigmentation1.14371582
68MP0002102_abnormal_ear_morphology1.14246358
69MP0002067_abnormal_sensory_capabilities1.12904439
70MP0002152_abnormal_brain_morphology1.12303935
71MP0002638_abnormal_pupillary_reflex1.10915150
72MP0006276_abnormal_autonomic_nervous1.10520964
73MP0000537_abnormal_urethra_morphology1.09876882
74MP0000579_abnormal_nail_morphology1.08360191
75MP0001963_abnormal_hearing_physiology1.08141804
76MP0003755_abnormal_palate_morphology1.08055158
77MP0001177_atelectasis1.07647114
78MP0000462_abnormal_digestive_system1.06994033
79MP0002249_abnormal_larynx_morphology1.06531677
80MP0003936_abnormal_reproductive_system1.06034864
81MP0001293_anophthalmia1.05648781
82MP0003385_abnormal_body_wall1.05572432
83MP0003634_abnormal_glial_cell1.04003522
84MP0004924_abnormal_behavior1.03477663
85MP0005386_behavior/neurological_phenoty1.03477663
86MP0008932_abnormal_embryonic_tissue1.02985420
87MP0004272_abnormal_basement_membrane1.02297905
88MP0009250_abnormal_appendicular_skeleto1.01825743
89MP0005377_hearing/vestibular/ear_phenot0.98698787
90MP0003878_abnormal_ear_physiology0.98698787
91MP0003632_abnormal_nervous_system0.98441104
92MP0002084_abnormal_developmental_patter0.97982685
93MP0002557_abnormal_social/conspecific_i0.97684631
94MP0000049_abnormal_middle_ear0.97181069
95MP0001905_abnormal_dopamine_level0.96392022
96MP0010678_abnormal_skin_adnexa0.95439022
97MP0003950_abnormal_plasma_membrane0.95074992
98MP0008995_early_reproductive_senescence0.94580286
99MP0009703_decreased_birth_body0.94055642
100MP0002752_abnormal_somatic_nervous0.93929941
101MP0005645_abnormal_hypothalamus_physiol0.93361465
102MP0000647_abnormal_sebaceous_gland0.93131910
103MP0002210_abnormal_sex_determination0.92552670
104MP0001340_abnormal_eyelid_morphology0.91295733
105MP0002116_abnormal_craniofacial_bone0.90913581
106MP0000627_abnormal_mammary_gland0.90126069
107MP0002751_abnormal_autonomic_nervous0.90019058
108MP0004782_abnormal_surfactant_physiolog0.89975814
109MP0002066_abnormal_motor_capabilities/c0.89852698
110MP0004957_abnormal_blastocyst_morpholog0.89365058
111MP0004811_abnormal_neuron_physiology0.88731515
112MP0003698_abnormal_male_reproductive0.88100373
113MP0010094_abnormal_chromosome_stability0.88014025
114MP0002735_abnormal_chemical_nociception0.86919449
115MP0000428_abnormal_craniofacial_morphol0.85640123
116MP0003938_abnormal_ear_development0.85116821
117MP0001968_abnormal_touch/_nociception0.84524933
118MP0000613_abnormal_salivary_gland0.83531420
119MP0010234_abnormal_vibrissa_follicle0.82967847
120MP0003935_abnormal_craniofacial_develop0.82711450
121MP0001919_abnormal_reproductive_system0.82613479
122MP0002092_abnormal_eye_morphology0.82547991
123MP0002653_abnormal_ependyma_morphology0.82387009
124MP0002075_abnormal_coat/hair_pigmentati0.81706512
125MP0008058_abnormal_DNA_repair0.81523985
126MP0002085_abnormal_embryonic_tissue0.80997875
127MP0001929_abnormal_gametogenesis0.80776604
128MP0000377_abnormal_hair_follicle0.80208101
129MP0000762_abnormal_tongue_morphology0.80026609
130MP0000750_abnormal_muscle_regeneration0.79833514
131MP0008789_abnormal_olfactory_epithelium0.79047467
132MP0000467_abnormal_esophagus_morphology0.78637999
133MP0000026_abnormal_inner_ear0.78394827
134MP0001664_abnormal_digestion0.78385069
135MP0004197_abnormal_fetal_growth/weight/0.78075273
136MP0002177_abnormal_outer_ear0.77752509
137MP0005253_abnormal_eye_physiology0.77632114
138MP0002233_abnormal_nose_morphology0.77592356
139MP0001145_abnormal_male_reproductive0.77326873
140MP0002081_perinatal_lethality0.77170329
141MP0002114_abnormal_axial_skeleton0.77136973
142MP0003941_abnormal_skin_development0.76782865
143MP0002234_abnormal_pharynx_morphology0.76730094
144MP0002229_neurodegeneration0.76688937
145MP0002108_abnormal_muscle_morphology0.76634469
146MP0000371_diluted_coat_color0.76570065
147MP0000470_abnormal_stomach_morphology0.75991662
148MP0009115_abnormal_fat_cell0.74653955
149MP0001944_abnormal_pancreas_morphology0.73485048
150MP0005551_abnormal_eye_electrophysiolog0.73367884
151MP0002796_impaired_skin_barrier0.72845123
152MP0001186_pigmentation_phenotype0.72179074

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)6.18869070
2Absent frontal sinuses (HP:0002688)5.15570759
3Asymmetry of the thorax (HP:0001555)4.64518401
4Microglossia (HP:0000171)4.31897980
5Deformed sella turcica (HP:0002681)4.10043776
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.99892233
7Abnormality of the frontal sinuses (HP:0002687)3.49180559
8Breast carcinoma (HP:0003002)3.31578830
9Abnormality of the sella turcica (HP:0002679)3.27294032
10Thyroid carcinoma (HP:0002890)3.26525446
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.25489544
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.25489544
13Concave nail (HP:0001598)3.22554994
14Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.16332783
15Long toe (HP:0010511)3.12439467
16Abnormality of the corticospinal tract (HP:0002492)2.91645944
17Irregular epiphyses (HP:0010582)2.90213072
18Termporal pattern (HP:0011008)2.78102448
19Insidious onset (HP:0003587)2.78102448
20Septate vagina (HP:0001153)2.76510262
21Macroorchidism (HP:0000053)2.73567424
22Epiphyseal dysplasia (HP:0002656)2.71613069
23Focal motor seizures (HP:0011153)2.70655292
24Hyperventilation (HP:0002883)2.69184756
25Curly hair (HP:0002212)2.69014597
26Germ cell neoplasia (HP:0100728)2.65813440
27Enlarged penis (HP:0000040)2.63169351
28Micronodular cirrhosis (HP:0001413)2.58810478
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54543874
30Abnormality of the labia minora (HP:0012880)2.46642336
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45421351
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.42342247
33Chromsome breakage (HP:0040012)2.40061460
34Hypopigmentation of the fundus (HP:0007894)2.39433643
35Testicular neoplasm (HP:0010788)2.35757941
36Neoplasm of the thyroid gland (HP:0100031)2.33026554
37Ulnar claw (HP:0001178)2.32677965
38Sensory axonal neuropathy (HP:0003390)2.29500685
39Hypoplastic pelvis (HP:0008839)2.26490401
40Ankle clonus (HP:0011448)2.24289949
41Epileptic encephalopathy (HP:0200134)2.18581685
42Delayed epiphyseal ossification (HP:0002663)2.17561208
43Relative macrocephaly (HP:0004482)2.17201559
44Peripheral hypomyelination (HP:0007182)2.16846278
45Atonic seizures (HP:0010819)2.12198491
46Small epiphyses (HP:0010585)2.11690957
47Alacrima (HP:0000522)2.10416685
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09308608
49Vitreoretinal degeneration (HP:0000655)2.08444147
50Syringomyelia (HP:0003396)2.06726657
51Spinal cord lesions (HP:0100561)2.06726657
52Progressive cerebellar ataxia (HP:0002073)2.04776156
53Cerebral hypomyelination (HP:0006808)2.03956516
54Abnormality of the carotid arteries (HP:0005344)2.02714983
55Spastic gait (HP:0002064)2.01885102
56Focal seizures (HP:0007359)2.01552023
57Abnormality of the phalanges of the hallux (HP:0010057)2.01172847
58Abnormal auditory evoked potentials (HP:0006958)1.99284171
59Broad-based gait (HP:0002136)1.99117119
60Decreased lacrimation (HP:0000633)1.98629346
61Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96869464
62Menstrual irregularities (HP:0000858)1.96247582
63Drooling (HP:0002307)1.94076177
64Excessive salivation (HP:0003781)1.94076177
65Fibular aplasia (HP:0002990)1.93699084
66Vertebral arch anomaly (HP:0008438)1.92647518
67Agitation (HP:0000713)1.91666462
68Cutaneous melanoma (HP:0012056)1.91539703
69Amyotrophic lateral sclerosis (HP:0007354)1.89544371
70Truncal obesity (HP:0001956)1.86832991
71Severe Myopia (HP:0011003)1.85381910
72Astigmatism (HP:0000483)1.84562599
73Morphological abnormality of the middle ear (HP:0008609)1.84206058
74Renovascular hypertension (HP:0100817)1.82295847
75Genetic anticipation (HP:0003743)1.82050604
76Renal dysplasia (HP:0000110)1.81869536
77Shawl scrotum (HP:0000049)1.81820424
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.81032817
79Aplasia involving bones of the upper limbs (HP:0009823)1.79941598
80Aplasia of the phalanges of the hand (HP:0009802)1.79941598
81Aplasia involving bones of the extremities (HP:0009825)1.79941598
82Gaze-evoked nystagmus (HP:0000640)1.79074453
83Deep philtrum (HP:0002002)1.78200365
84Transitional cell carcinoma of the bladder (HP:0006740)1.77599569
85Abnormality of the nasal septum (HP:0000419)1.77188016
86Poor coordination (HP:0002370)1.75200545
87Flat capital femoral epiphysis (HP:0003370)1.74093067
88Meckel diverticulum (HP:0002245)1.73770058
89Capillary hemangiomas (HP:0005306)1.73745806
90Neurofibrillary tangles (HP:0002185)1.73709895
91Heterotopia (HP:0002282)1.73006235
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.72585093
93Abnormality of the pubic bones (HP:0003172)1.70611775
94Abnormality of the diencephalon (HP:0010662)1.70379598
95Buphthalmos (HP:0000557)1.70350851
96Hyperacusis (HP:0010780)1.70307418
97Neoplasm of the heart (HP:0100544)1.70297486
98Volvulus (HP:0002580)1.69238654
99Bladder neoplasm (HP:0009725)1.69099077
100Bladder carcinoma (HP:0002862)1.69099077
101Elfin facies (HP:0004428)1.68994624
102Pheochromocytoma (HP:0002666)1.68542792
103Pancreatic cysts (HP:0001737)1.66808451
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66732064
105Flat acetabular roof (HP:0003180)1.65941451
106Hypoplastic ischia (HP:0003175)1.65158446
107Abnormality of incisor morphology (HP:0011063)1.64971672
108Vaginal atresia (HP:0000148)1.64417734
109Thickened helices (HP:0000391)1.63471013
110Embryonal renal neoplasm (HP:0011794)1.62892518
111Myokymia (HP:0002411)1.62715762
112Abnormality of chromosome stability (HP:0003220)1.62077688
113Absent speech (HP:0001344)1.61879325
114Anteriorly placed anus (HP:0001545)1.61775182
115Sparse lateral eyebrow (HP:0005338)1.61644770
116Genital tract atresia (HP:0001827)1.61455723
117Nephroblastoma (Wilms tumor) (HP:0002667)1.61444660
118Cystic hygroma (HP:0000476)1.61158304
119Fibular hypoplasia (HP:0003038)1.60719041
120Cupped ear (HP:0000378)1.60601439
121Gastroesophageal reflux (HP:0002020)1.60592602
122Midline defect of the nose (HP:0004122)1.60226639
123Leiomyosarcoma (HP:0100243)1.60102079
124Uterine leiomyosarcoma (HP:0002891)1.60102079
125Abnormality of the ileum (HP:0001549)1.60030458
126Hamartoma (HP:0010566)1.59164188
127Abnormality of the parietal bone (HP:0002696)1.58836211
128Dental crowding (HP:0000678)1.57810360
129Megalocornea (HP:0000485)1.57233421
130Dysmetria (HP:0001310)1.56894125
131Chronic hepatic failure (HP:0100626)1.56371870
132Tracheomalacia (HP:0002779)1.56011058
133Medial flaring of the eyebrow (HP:0010747)1.55538581
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55006227
135Lower limb muscle weakness (HP:0007340)1.53797627
136Cerebral inclusion bodies (HP:0100314)1.53704623
137Abnormality of calcium-phosphate metabolism (HP:0100530)1.53702833
138Truncal ataxia (HP:0002078)1.52635039
139Absent epiphyses (HP:0010577)1.51985502
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51985502
141Megalencephaly (HP:0001355)1.50034655
142Supernumerary spleens (HP:0009799)1.49477521
143Urinary urgency (HP:0000012)1.49260982
144Aqueductal stenosis (HP:0002410)1.48934513
145Urinary bladder sphincter dysfunction (HP:0002839)1.46715339
146Visual hallucinations (HP:0002367)1.46609210
147Scanning speech (HP:0002168)1.46289568
148Abnormality of femoral epiphyses (HP:0006499)1.46263655
149Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.46263655
150Mixed hearing impairment (HP:0000410)1.45944918
151Akinesia (HP:0002304)1.44699415
152Long nose (HP:0003189)1.44217452
153Clumsiness (HP:0002312)1.43759508
154Coronal craniosynostosis (HP:0004440)1.42659186
155Shoulder girdle muscle weakness (HP:0003547)1.42601378
156Papillary thyroid carcinoma (HP:0002895)1.41844673
157Neoplasm of the oral cavity (HP:0100649)1.41739777
158Dialeptic seizures (HP:0011146)1.41714588
159Abnormality of the femoral head (HP:0003368)1.41529250
160Abnormality of the epiphysis of the femoral head (HP:0010574)1.40386811
161Hypoplastic iliac wings (HP:0002866)1.40037577
162Omphalocele (HP:0001539)1.39729806
163Myelomeningocele (HP:0002475)1.39573226
164Abnormality of salivation (HP:0100755)1.39555932
165Absence seizures (HP:0002121)1.39455876
166Abnormality of chromosome segregation (HP:0002916)1.39249639
167Absent septum pellucidum (HP:0001331)1.39191599
168Mild short stature (HP:0003502)1.39178808
169Dysdiadochokinesis (HP:0002075)1.38396685
170Overriding aorta (HP:0002623)1.38300620
171Gait imbalance (HP:0002141)1.38277862
172Protruding tongue (HP:0010808)1.38006004
173Morphological abnormality of the inner ear (HP:0011390)1.37126315
174Esophageal atresia (HP:0002032)1.36583939
175Abnormal hair whorl (HP:0010721)1.36164544
176Abnormality of the ischium (HP:0003174)1.35786968
177Abnormality of the incisor (HP:0000676)1.35520695
178Abnormality of the middle phalanges of the toes (HP:0010183)1.35395639
179Morphological abnormality of the pyramidal tract (HP:0002062)1.34937148
180Neuroendocrine neoplasm (HP:0100634)1.34595483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL25.32615706
2PIK3CA4.97463393
3STK393.14738400
4SIK13.08713236
5PKN23.08416839
6BCR3.04205939
7TRIB32.88524441
8PNCK2.78257606
9MARK12.61848465
10TRIM282.60377669
11RPS6KB22.50387988
12OXSR12.33758705
13MAP3K122.15236231
14TNIK2.03909564
15MAP3K41.98428465
16FRK1.97746108
17PLK21.92584909
18MUSK1.90185529
19CASK1.88634891
20CHUK1.83935262
21WNK31.83392018
22MKNK11.80471561
23NTRK31.73050358
24CDK191.70013517
25CSNK1A1L1.53397095
26RPS6KB11.51635974
27MKNK21.51206516
28UHMK11.50799536
29CSNK1G31.49147300
30CDC71.49052505
31MAPKAPK31.46114657
32WNK11.45415530
33ERBB31.44977114
34CSNK1G21.39875499
35LATS11.37672087
36WNK41.37327230
37PLK31.36303597
38MAP2K71.33924152
39NTRK11.31185309
40MINK11.30608368
41AKT31.30307285
42MAP3K91.28657249
43DYRK21.28637420
44BRD41.27081208
45NTRK21.25988085
46MAPK131.25453714
47TYRO31.23426975
48KSR11.23176242
49PAK61.19411752
50NEK61.17594145
51MAP2K21.16058161
52FGFR21.14049418
53MET1.11496712
54CDK121.10938698
55CSNK1G11.09107421
56WEE11.09055097
57SRPK11.06862003
58TSSK61.06349482
59NUAK11.04330467
60LIMK11.00843557
61EIF2AK31.00678889
62SGK21.00145872
63PLK40.99248561
64EPHA20.98859109
65MAP2K10.98681307
66EEF2K0.97013833
67SGK2230.95795153
68SGK4940.95795153
69BUB10.93025719
70MELK0.91552020
71BMPR1B0.91164542
72CAMK2B0.90888486
73RET0.90230871
74CAMK2G0.90041726
75SIK30.87952725
76CDK140.86851704
77PKN10.86649126
78CCNB10.86074378
79LATS20.85072109
80ACVR1B0.84909985
81EIF2AK20.84450032
82ROCK20.81632143
83FGFR40.81540266
84CDK50.80899347
85BRSK20.80736089
86PAK30.79966565
87EPHA40.77369215
88STK30.75858560
89PDGFRA0.75551647
90DYRK1A0.75368871
91FGFR30.74271648
92PRKCZ0.73444939
93BMPR20.73055325
94CDK180.72949257
95RPS6KA20.72206827
96FGFR10.72130969
97SGK30.71757056
98MAPKAPK50.71028882
99CDK150.67936692
100EPHB10.66993472
101EIF2AK10.65857654
102CSNK1E0.65791324
103CHEK20.65484232
104MAP2K40.62935017
105DDR20.62736251
106TAF10.61721974
107BRSK10.61655168
108PRKCI0.61080313
109CDK10.60548269
110CHEK10.60543650
111ILK0.60304071
112CSNK1D0.60121691
113PBK0.59756211
114MAPK100.59502701
115DYRK1B0.59502654
116CAMKK10.59234829
117FER0.58658897
118RPS6KA40.58479468
119CDK11A0.58332147
120PRKCE0.57204397
121YES10.56439309
122MTOR0.55685283
123VRK10.55189510
124ALK0.54855128
125CAMK2A0.54175233
126DMPK0.53616432
127STK240.52061881
128PRKCG0.51010540
129CDK20.49739342
130ATM0.49724021
131ICK0.49594551
132STK110.49477347
133PRKD30.48819397
134SGK10.48799812
135TTK0.48365683
136FGR0.47371405
137CSNK1A10.46912883
138STK38L0.46764010
139CAMK2D0.46649344
140GSK3B0.46329538
141MAP3K20.45946197
142PHKG20.40879134
143PHKG10.40879134
144CAMK40.38929227
145STK380.38846203
146CDK70.38228930
147AKT20.37548143
148PRKACB0.36269766
149MAPK90.34752897
150MAPK80.33015994
151PRKAA10.31718215
152PDGFRB0.31191456
153CAMKK20.31084334
154PDPK10.29892067

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60120088
2Nicotine addiction_Homo sapiens_hsa050332.09739188
3Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.01953538
4mTOR signaling pathway_Homo sapiens_hsa041501.93119042
5Thyroid hormone signaling pathway_Homo sapiens_hsa049191.86964519
6Longevity regulating pathway - mammal_Homo sapiens_hsa042111.83693823
7Axon guidance_Homo sapiens_hsa043601.82653871
8AMPK signaling pathway_Homo sapiens_hsa041521.71598196
9GABAergic synapse_Homo sapiens_hsa047271.68214125
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62214225
11Hedgehog signaling pathway_Homo sapiens_hsa043401.61252714
12mRNA surveillance pathway_Homo sapiens_hsa030151.59926060
13Long-term depression_Homo sapiens_hsa047301.58077208
14Glutamatergic synapse_Homo sapiens_hsa047241.57381054
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55753172
16Dopaminergic synapse_Homo sapiens_hsa047281.55521712
17Long-term potentiation_Homo sapiens_hsa047201.51140841
18Amphetamine addiction_Homo sapiens_hsa050311.50257289
19Oocyte meiosis_Homo sapiens_hsa041141.49802275
20Circadian entrainment_Homo sapiens_hsa047131.47051047
21Thyroid cancer_Homo sapiens_hsa052161.46003636
22Morphine addiction_Homo sapiens_hsa050321.44714550
23Synaptic vesicle cycle_Homo sapiens_hsa047211.44040342
24Hippo signaling pathway_Homo sapiens_hsa043901.38908257
25Serotonergic synapse_Homo sapiens_hsa047261.37149851
26Renal cell carcinoma_Homo sapiens_hsa052111.35422851
27Basal transcription factors_Homo sapiens_hsa030221.35237964
28Melanoma_Homo sapiens_hsa052181.35059360
29Dorso-ventral axis formation_Homo sapiens_hsa043201.32374724
30Cocaine addiction_Homo sapiens_hsa050301.31527915
31Wnt signaling pathway_Homo sapiens_hsa043101.29608695
32RNA transport_Homo sapiens_hsa030131.26386591
33Prolactin signaling pathway_Homo sapiens_hsa049171.25615109
34Cell cycle_Homo sapiens_hsa041101.25461087
35Basal cell carcinoma_Homo sapiens_hsa052171.25312499
36ErbB signaling pathway_Homo sapiens_hsa040121.23588479
37Ether lipid metabolism_Homo sapiens_hsa005651.21275295
38Steroid biosynthesis_Homo sapiens_hsa001001.18963343
39Inositol phosphate metabolism_Homo sapiens_hsa005621.18009291
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17838850
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17766384
42Vibrio cholerae infection_Homo sapiens_hsa051101.17302972
43Insulin signaling pathway_Homo sapiens_hsa049101.17245807
44Tight junction_Homo sapiens_hsa045301.16558525
45Propanoate metabolism_Homo sapiens_hsa006401.14576551
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.13423819
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10333016
48ABC transporters_Homo sapiens_hsa020101.10223721
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10221719
50Spliceosome_Homo sapiens_hsa030401.08094495
51Phototransduction_Homo sapiens_hsa047441.07594354
52Gap junction_Homo sapiens_hsa045401.06689244
53Melanogenesis_Homo sapiens_hsa049161.06649663
54Protein export_Homo sapiens_hsa030601.06540302
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05514688
56Olfactory transduction_Homo sapiens_hsa047401.05006195
57Alcoholism_Homo sapiens_hsa050341.04453890
58TGF-beta signaling pathway_Homo sapiens_hsa043501.02175214
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01536335
60Insulin secretion_Homo sapiens_hsa049111.01382067
61RNA polymerase_Homo sapiens_hsa030201.00929450
62Cholinergic synapse_Homo sapiens_hsa047251.00873269
63Insulin resistance_Homo sapiens_hsa049311.00045196
64Non-small cell lung cancer_Homo sapiens_hsa052230.98188906
65Type II diabetes mellitus_Homo sapiens_hsa049300.96508560
66Salivary secretion_Homo sapiens_hsa049700.96088354
67Lysine degradation_Homo sapiens_hsa003100.94710819
68Renin secretion_Homo sapiens_hsa049240.94705261
69Butanoate metabolism_Homo sapiens_hsa006500.94295868
70FoxO signaling pathway_Homo sapiens_hsa040680.93862352
71Glucagon signaling pathway_Homo sapiens_hsa049220.91344987
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.90026836
73Gastric acid secretion_Homo sapiens_hsa049710.89925704
74Taste transduction_Homo sapiens_hsa047420.88294994
75Selenocompound metabolism_Homo sapiens_hsa004500.87103401
76RNA degradation_Homo sapiens_hsa030180.85330391
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84532010
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83956714
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83902062
80Estrogen signaling pathway_Homo sapiens_hsa049150.83824340
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83635298
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83393615
83cAMP signaling pathway_Homo sapiens_hsa040240.82569283
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82197141
85Proteoglycans in cancer_Homo sapiens_hsa052050.81398677
86Oxytocin signaling pathway_Homo sapiens_hsa049210.79505384
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79300112
88Collecting duct acid secretion_Homo sapiens_hsa049660.77321076
89Colorectal cancer_Homo sapiens_hsa052100.77194081
90Notch signaling pathway_Homo sapiens_hsa043300.76761243
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76641591
92Ras signaling pathway_Homo sapiens_hsa040140.76073936
93MAPK signaling pathway_Homo sapiens_hsa040100.75982756
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75708021
95ECM-receptor interaction_Homo sapiens_hsa045120.74362776
96Nucleotide excision repair_Homo sapiens_hsa034200.74336531
97Sphingolipid metabolism_Homo sapiens_hsa006000.73469156
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73166087
99Fanconi anemia pathway_Homo sapiens_hsa034600.71969792
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.70603126
101Non-homologous end-joining_Homo sapiens_hsa034500.70361548
102MicroRNAs in cancer_Homo sapiens_hsa052060.70182349
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70007416
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69509718
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69406145
106GnRH signaling pathway_Homo sapiens_hsa049120.68661051
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68194570
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66917901
109Glioma_Homo sapiens_hsa052140.66633195
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.66482631
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66412106
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64569480
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64480177
114Choline metabolism in cancer_Homo sapiens_hsa052310.64262058
115Chronic myeloid leukemia_Homo sapiens_hsa052200.64131304
116Ovarian steroidogenesis_Homo sapiens_hsa049130.62172386
117Prostate cancer_Homo sapiens_hsa052150.61663096
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61468327
119Mismatch repair_Homo sapiens_hsa034300.59516572
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.59282845
121Pathways in cancer_Homo sapiens_hsa052000.58870398
122Adherens junction_Homo sapiens_hsa045200.58782902
123VEGF signaling pathway_Homo sapiens_hsa043700.58567710
124Regulation of autophagy_Homo sapiens_hsa041400.58542589
125Vitamin B6 metabolism_Homo sapiens_hsa007500.58294932
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58079718
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57799218
128Calcium signaling pathway_Homo sapiens_hsa040200.56706981
129Fatty acid elongation_Homo sapiens_hsa000620.56095397
130Circadian rhythm_Homo sapiens_hsa047100.55769812
131Endocytosis_Homo sapiens_hsa041440.55177197
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54649478
133Thyroid hormone synthesis_Homo sapiens_hsa049180.54261016
134Focal adhesion_Homo sapiens_hsa045100.53347210
135Endometrial cancer_Homo sapiens_hsa052130.53018958
136Rap1 signaling pathway_Homo sapiens_hsa040150.53007178
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52321241
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50300499
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49897425

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