APPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.73066305
2nuclear pore complex assembly (GO:0051292)5.62637982
3nuclear pore organization (GO:0006999)5.36225062
4regulation of relaxation of muscle (GO:1901077)5.00730773
5interkinetic nuclear migration (GO:0022027)4.88276890
6muscle filament sliding (GO:0030049)4.57056400
7actin-myosin filament sliding (GO:0033275)4.57056400
8actin-mediated cell contraction (GO:0070252)4.44650756
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33280017
10cytoplasmic mRNA processing body assembly (GO:0033962)4.24715316
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20419209
12pore complex assembly (GO:0046931)4.20308303
13vocalization behavior (GO:0071625)4.19187689
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17689895
15monoubiquitinated protein deubiquitination (GO:0035520)4.14034853
16synaptic vesicle exocytosis (GO:0016079)4.08376181
17neuron cell-cell adhesion (GO:0007158)4.05633760
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.02339334
19protein localization to synapse (GO:0035418)4.01875084
20regulation of DNA endoreduplication (GO:0032875)3.94271123
21regulation of synaptic vesicle exocytosis (GO:2000300)3.93505926
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83867868
23mitotic G2 DNA damage checkpoint (GO:0007095)3.83198078
24glutamate receptor signaling pathway (GO:0007215)3.82420759
25regulation of glutamate receptor signaling pathway (GO:1900449)3.74747150
26sarcoplasmic reticulum calcium ion transport (GO:0070296)3.72492104
27synaptic vesicle maturation (GO:0016188)3.69884877
28otic vesicle formation (GO:0030916)3.62921472
29presynaptic membrane assembly (GO:0097105)3.57706557
30actin filament-based movement (GO:0030048)3.55165349
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.54453503
32regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.53562036
33myofibril assembly (GO:0030239)3.52832265
34regulation of pigment cell differentiation (GO:0050932)3.52780888
35synaptic transmission, glutamatergic (GO:0035249)3.52581787
36phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.52464811
37glutamate secretion (GO:0014047)3.51245245
38regulation of synaptic vesicle transport (GO:1902803)3.51122272
39double-strand break repair via nonhomologous end joining (GO:0006303)3.49637697
40non-recombinational repair (GO:0000726)3.49637697
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49435044
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.47773872
43nucleus localization (GO:0051647)3.46032383
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.45741029
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45741029
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45741029
47skeletal muscle contraction (GO:0003009)3.43563935
48regulation of cell communication by electrical coupling (GO:0010649)3.42227123
49neuron-neuron synaptic transmission (GO:0007270)3.42160546
50mitotic G2/M transition checkpoint (GO:0044818)3.41026227
51regulation of sister chromatid cohesion (GO:0007063)3.40423519
52prenylation (GO:0097354)3.38976143
53protein prenylation (GO:0018342)3.38976143
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38229715
55locomotory exploration behavior (GO:0035641)3.37631451
56neuron recognition (GO:0008038)3.36297500
57transmission of nerve impulse (GO:0019226)3.34589115
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34483510
59layer formation in cerebral cortex (GO:0021819)3.33969113
60Golgi to endosome transport (GO:0006895)3.32250745
61regulation of skeletal muscle contraction (GO:0014819)3.29891169
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.26706630
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.26703776
64presynaptic membrane organization (GO:0097090)3.24327040
65synaptic vesicle endocytosis (GO:0048488)3.22221714
66sister chromatid cohesion (GO:0007062)3.21367885
67neuronal action potential propagation (GO:0019227)3.17495502
68cardiac myofibril assembly (GO:0055003)3.15230832
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14107126
70regulation of vesicle fusion (GO:0031338)3.13329142
71cardiac muscle hypertrophy (GO:0003300)3.11627626
72sarcomere organization (GO:0045214)3.11411558
73axonal fasciculation (GO:0007413)3.10162988
74neural tube formation (GO:0001841)3.09374560
75neurotransmitter secretion (GO:0007269)3.07111211
76long-term synaptic potentiation (GO:0060291)3.05458597
77regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04758572
78positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.04636111
79startle response (GO:0001964)3.04347081
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03621782
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.01483514
82postsynaptic membrane organization (GO:0001941)3.01199551
83exploration behavior (GO:0035640)2.99449955
84cerebellar Purkinje cell differentiation (GO:0021702)2.98640305
85regulation of transforming growth factor beta2 production (GO:0032909)2.97777311
86negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96008682
87striated muscle hypertrophy (GO:0014897)2.94746055
88regulation of dendritic spine morphogenesis (GO:0061001)2.94681991
89neurotransmitter-gated ion channel clustering (GO:0072578)2.94315198
90long-term memory (GO:0007616)2.94238273
91IMP metabolic process (GO:0046040)2.93755292
92regulation of neuronal synaptic plasticity (GO:0048168)2.93131411
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92764122
94regulation of postsynaptic membrane potential (GO:0060078)2.91259630
95regulation of neurotransmitter secretion (GO:0046928)2.90521766
96regulation of actin filament-based movement (GO:1903115)2.89893990
97retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89473064
98negative regulation of DNA repair (GO:0045738)2.87972601
99regulation of synapse structural plasticity (GO:0051823)2.87402838
100microtubule anchoring (GO:0034453)2.87244078
101vesicle transport along microtubule (GO:0047496)2.87207709
102histone H3-K36 demethylation (GO:0070544)2.87183604
103negative regulation of neurotransmitter secretion (GO:0046929)2.87044643
104protein targeting to Golgi (GO:0000042)2.86968647
105establishment of protein localization to Golgi (GO:0072600)2.86522286
106dendrite morphogenesis (GO:0048813)2.86375727
107regulation of RNA export from nucleus (GO:0046831)2.85823799
108response to histamine (GO:0034776)2.85487866
109negative regulation of DNA recombination (GO:0045910)2.84142991
110dendritic spine morphogenesis (GO:0060997)2.82678423
111positive regulation of synapse maturation (GO:0090129)2.81743470
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81165376
113glycogen catabolic process (GO:0005980)2.78295492
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.76524683
115adult heart development (GO:0007512)2.75573611
116regulation of glucokinase activity (GO:0033131)2.75460557
117regulation of hexokinase activity (GO:1903299)2.75460557
118synapse assembly (GO:0007416)2.71995742
119ribosome assembly (GO:0042255)2.71344386
120cellular polysaccharide catabolic process (GO:0044247)2.70923758
121cellular potassium ion homeostasis (GO:0030007)2.70712941
122central nervous system projection neuron axonogenesis (GO:0021952)2.70686225
123regulation of establishment of cell polarity (GO:2000114)2.69354560
124DNA unwinding involved in DNA replication (GO:0006268)2.68915368
125dendrite development (GO:0016358)2.68463894
126innervation (GO:0060384)2.68040536
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67319333
128regulation of synaptic plasticity (GO:0048167)2.67083756
129positive regulation of DNA-templated transcription, initiation (GO:2000144)2.65856789
130striated muscle contraction (GO:0006941)2.65691246
131regulation of histone H3-K9 methylation (GO:0051570)2.65403688
132carnitine shuttle (GO:0006853)2.65176575
133actomyosin structure organization (GO:0031032)2.65014626
134regulation of neurotransmitter transport (GO:0051588)2.64448315
135intracellular lipid transport (GO:0032365)2.64127965
136response to inactivity (GO:0014854)2.62246345
137positive regulation of membrane potential (GO:0045838)2.62027837
138positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61496769
139NLS-bearing protein import into nucleus (GO:0006607)2.60861464
140learning (GO:0007612)2.60276059
141regulation of synaptic transmission, GABAergic (GO:0032228)2.59577875
142translesion synthesis (GO:0019985)2.58958467
143regulation of synapse maturation (GO:0090128)2.58814448
144regulation of DNA-templated transcription, initiation (GO:2000142)2.58659308
145striatum development (GO:0021756)2.58489591
146eye photoreceptor cell differentiation (GO:0001754)2.58175387
147photoreceptor cell differentiation (GO:0046530)2.58175387
148glucan catabolic process (GO:0009251)2.58145302
149definitive hemopoiesis (GO:0060216)2.57921574
150regulation of dendritic spine development (GO:0060998)2.57264459
151cellular response to ethanol (GO:0071361)2.56745881
152response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.56569445
153mating behavior (GO:0007617)2.55565263
154regulation of chromatin silencing (GO:0031935)2.55291369
155neurotransmitter transport (GO:0006836)2.54583190
156membrane hyperpolarization (GO:0060081)2.53222363
157cerebellar granule cell differentiation (GO:0021707)2.53008063
158positive regulation of dendritic spine development (GO:0060999)2.52780951
159membrane depolarization (GO:0051899)2.52418078
160protein K63-linked deubiquitination (GO:0070536)2.52417266
161regulation of acyl-CoA biosynthetic process (GO:0050812)2.51838136
162regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.51372917
163CENP-A containing nucleosome assembly (GO:0034080)2.50615528
164regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.50505426
165regulation of centriole replication (GO:0046599)2.49973231
166AMP metabolic process (GO:0046033)2.49668353
167regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49458679
168cell migration in hindbrain (GO:0021535)2.49351745
169regulation of centrosome duplication (GO:0010824)2.48814925
170positive regulation of synapse assembly (GO:0051965)2.48660632
171regulation of Golgi to plasma membrane protein transport (GO:0042996)2.48531937
172polysaccharide catabolic process (GO:0000272)2.47950086
173negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47599171
174ether lipid metabolic process (GO:0046485)2.47276261
175dosage compensation (GO:0007549)2.47141555
176regulation of protein glycosylation (GO:0060049)2.46912339
177DNA topological change (GO:0006265)2.46877542
178centrosome duplication (GO:0051298)2.46769056
179behavioral defense response (GO:0002209)2.46533815
180behavioral fear response (GO:0001662)2.46533815
181cardiac muscle adaptation (GO:0014887)2.46219538
182muscle hypertrophy in response to stress (GO:0003299)2.46219538
183organelle transport along microtubule (GO:0072384)2.45457096
184membrane depolarization during action potential (GO:0086010)2.44559861
185regulation of respiratory system process (GO:0044065)2.44472009
186proline transport (GO:0015824)2.43551956
187negative regulation of neurotransmitter transport (GO:0051589)2.43196423
188positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42806787
189synaptic transmission (GO:0007268)2.41677516
190regulation of synapse assembly (GO:0051963)2.40082256
191histone H3-K4 trimethylation (GO:0080182)2.39625147
192establishment of nucleus localization (GO:0040023)2.37093464
193negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36612595
194negative regulation of cell killing (GO:0031342)2.36612595
195positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.35622734
196response to auditory stimulus (GO:0010996)2.33699983
197cerebral cortex radially oriented cell migration (GO:0021799)2.32839005
198regulation of cAMP-dependent protein kinase activity (GO:2000479)2.32172709
199detection of calcium ion (GO:0005513)2.32090507
200regulation of synaptic transmission (GO:0050804)2.31132773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29359758
2GBX2_23144817_ChIP-Seq_PC3_Human3.73325556
3E2F7_22180533_ChIP-Seq_HELA_Human2.88449814
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62598917
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57908545
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46747710
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46504776
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.37636026
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35556003
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28210833
11TAF15_26573619_Chip-Seq_HEK293_Human2.24755141
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23566992
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21560123
14AR_21572438_ChIP-Seq_LNCaP_Human2.18104756
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17543173
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15050348
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12869057
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11548245
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09278103
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07223421
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04946675
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04946675
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.04847174
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99452081
25FUS_26573619_Chip-Seq_HEK293_Human1.99236841
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.98263886
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96868798
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95987369
29SMAD4_21799915_ChIP-Seq_A2780_Human1.95006358
30REST_21632747_ChIP-Seq_MESCs_Mouse1.93908370
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88168952
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88062868
33P300_19829295_ChIP-Seq_ESCs_Human1.87959086
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85535970
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83411374
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.82879367
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.77616961
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77131460
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.76891252
40GATA1_22025678_ChIP-Seq_K562_Human1.75413109
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74086394
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73041742
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69702252
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69606887
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68115386
46DROSHA_22980978_ChIP-Seq_HELA_Human1.63553665
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.63425074
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.61315190
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59560689
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59541989
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58511450
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57686531
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.56421784
54RNF2_27304074_Chip-Seq_NSC_Mouse1.55720176
55ELK1_19687146_ChIP-ChIP_HELA_Human1.54028379
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.53779725
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53212524
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.52303295
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51974697
60STAT3_23295773_ChIP-Seq_U87_Human1.51166281
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50345346
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50275447
63AR_21909140_ChIP-Seq_LNCAP_Human1.50155940
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49780560
65IGF1R_20145208_ChIP-Seq_DFB_Human1.49002532
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48105251
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47466949
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47466949
69TP53_16413492_ChIP-PET_HCT116_Human1.47147992
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45647265
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.42188486
72EWS_26573619_Chip-Seq_HEK293_Human1.41542622
73ER_23166858_ChIP-Seq_MCF-7_Human1.40095430
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39592697
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.39240139
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.39138810
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39124041
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38076459
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37930060
80TCF4_23295773_ChIP-Seq_U87_Human1.37725808
81AR_25329375_ChIP-Seq_VCAP_Human1.36902654
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34305875
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.33614048
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.32577549
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32069919
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.31623942
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30288057
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.30042679
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29831230
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29563572
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.28327850
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27267964
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25842892
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25842892
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.25222817
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23154738
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.22908936
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22272908
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.21897864
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.21505389
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21306384
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20871165
103RUNX2_22187159_ChIP-Seq_PCA_Human1.20306870
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20209414
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19492729
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19392659
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.19279618
108TP53_18474530_ChIP-ChIP_U2OS_Human1.18876956
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18786099
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.17730628
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17704002
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17313557
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17153433
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16899224
115CBP_20019798_ChIP-Seq_JUKART_Human1.16899224
116* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16711010
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16631484
118P53_22387025_ChIP-Seq_ESCs_Mouse1.15300179
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14707043
120AHR_22903824_ChIP-Seq_MCF-7_Human1.14329582
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13700148
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13609544
123VDR_22108803_ChIP-Seq_LS180_Human1.13204441
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13120892
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12064339
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12050131
127AR_19668381_ChIP-Seq_PC3_Human1.10058854
128EGR1_19374776_ChIP-ChIP_THP-1_Human1.09531582
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09430937
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.09003046
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08299062
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08093667
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07962595
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07550343
135P300_18555785_Chip-Seq_ESCs_Mouse1.07108361
136CDX2_22108803_ChIP-Seq_LS180_Human1.06976585
137SOX2_18555785_Chip-Seq_ESCs_Mouse1.06741220
138JUN_21703547_ChIP-Seq_K562_Human1.06648527
139NMYC_18555785_Chip-Seq_ESCs_Mouse1.05901458
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05275908
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04594542
142OCT4_18555785_Chip-Seq_ESCs_Mouse1.04339998
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03612438
144NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03595564
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03482022
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02972937
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00639927
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99439149
149STAT3_18555785_Chip-Seq_ESCs_Mouse0.99149165
150BRD4_25478319_ChIP-Seq_HGPS_Human0.98414794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.60606771
2MP0004859_abnormal_synaptic_plasticity4.65452471
3MP0003880_abnormal_central_pattern4.06069809
4MP0003635_abnormal_synaptic_transmissio3.27496125
5MP0010352_gastrointestinal_tract_polyps3.11786577
6MP0003787_abnormal_imprinting2.91320261
7MP0004270_analgesia2.82681268
8MP0003646_muscle_fatigue2.82142212
9MP0009745_abnormal_behavioral_response2.81995965
10MP0002063_abnormal_learning/memory/cond2.78131858
11MP0002396_abnormal_hematopoietic_system2.76679096
12MP0004036_abnormal_muscle_relaxation2.64719125
13MP0000569_abnormal_digit_pigmentation2.60527181
14MP0009046_muscle_twitch2.59852639
15MP0004084_abnormal_cardiac_muscle2.55449670
16MP0001968_abnormal_touch/_nociception2.47435281
17MP0002877_abnormal_melanocyte_morpholog2.44903656
18MP0002064_seizures2.44018039
19MP0002572_abnormal_emotion/affect_behav2.32953954
20MP0005423_abnormal_somatic_nervous2.32771304
21MP0001486_abnormal_startle_reflex2.30560372
22MP0002734_abnormal_mechanical_nocicepti2.22541406
23MP0002272_abnormal_nervous_system2.14309574
24MP0002735_abnormal_chemical_nociception2.09248047
25MP0001188_hyperpigmentation2.07796686
26MP0004215_abnormal_myocardial_fiber2.06266213
27MP0010234_abnormal_vibrissa_follicle2.02899451
28MP0001984_abnormal_olfaction1.99325564
29MP0000778_abnormal_nervous_system1.97877375
30MP0001440_abnormal_grooming_behavior1.97425145
31MP0010094_abnormal_chromosome_stability1.95316815
32MP0002736_abnormal_nociception_after1.92439977
33MP0009780_abnormal_chondrocyte_physiolo1.91815945
34MP0009697_abnormal_copulation1.90859854
35MP0004087_abnormal_muscle_fiber1.89644054
36MP0001501_abnormal_sleep_pattern1.89199285
37MP0000749_muscle_degeneration1.88842720
38MP0002184_abnormal_innervation1.86593628
39MP0010678_abnormal_skin_adnexa1.86534663
40MP0004185_abnormal_adipocyte_glucose1.79988257
41MP0002067_abnormal_sensory_capabilities1.79824560
42MP0002837_dystrophic_cardiac_calcinosis1.76468525
43MP0000383_abnormal_hair_follicle1.74891537
44MP0002557_abnormal_social/conspecific_i1.66718024
45MP0005646_abnormal_pituitary_gland1.65205295
46MP0003221_abnormal_cardiomyocyte_apopto1.57235261
47MP0001502_abnormal_circadian_rhythm1.56509397
48MP0005645_abnormal_hypothalamus_physiol1.55875522
49MP0001970_abnormal_pain_threshold1.55591173
50MP0004924_abnormal_behavior1.54556335
51MP0005386_behavior/neurological_phenoty1.54556335
52MP0005620_abnormal_muscle_contractility1.54189118
53MP0000747_muscle_weakness1.51384320
54MP0006276_abnormal_autonomic_nervous1.50799501
55MP0002106_abnormal_muscle_physiology1.47867600
56MP0008569_lethality_at_weaning1.47555468
57MP0010386_abnormal_urinary_bladder1.46532916
58MP0002822_catalepsy1.46128057
59MP0003121_genomic_imprinting1.45602044
60MP0002166_altered_tumor_susceptibility1.45152458
61MP0002733_abnormal_thermal_nociception1.43718017
62MP0005551_abnormal_eye_electrophysiolog1.42308602
63MP0002269_muscular_atrophy1.42015500
64MP0004134_abnormal_chest_morphology1.41043128
65MP0004957_abnormal_blastocyst_morpholog1.41009559
66MP0000759_abnormal_skeletal_muscle1.38872506
67MP0000751_myopathy1.38684254
68MP0002882_abnormal_neuron_morphology1.34005775
69MP0004130_abnormal_muscle_cell1.33265692
70MP0004808_abnormal_hematopoietic_stem1.31282033
71MP0000631_abnormal_neuroendocrine_gland1.31179372
72MP0008877_abnormal_DNA_methylation1.30803481
73MP0004811_abnormal_neuron_physiology1.30409889
74MP0003077_abnormal_cell_cycle1.29199858
75MP0005174_abnormal_tail_pigmentation1.29094729
76MP0010307_abnormal_tumor_latency1.28771016
77MP0000955_abnormal_spinal_cord1.28661377
78MP0003122_maternal_imprinting1.28293694
79MP0010630_abnormal_cardiac_muscle1.27514934
80MP0003984_embryonic_growth_retardation1.25415159
81MP0006292_abnormal_olfactory_placode1.25096168
82MP0005666_abnormal_adipose_tissue1.24875821
83MP0002088_abnormal_embryonic_growth/wei1.23866914
84MP0005369_muscle_phenotype1.23312233
85MP0002127_abnormal_cardiovascular_syste1.23035288
86MP0003941_abnormal_skin_development1.22482732
87MP0005499_abnormal_olfactory_system1.22098249
88MP0005394_taste/olfaction_phenotype1.22098249
89MP0001529_abnormal_vocalization1.21239779
90MP0001661_extended_life_span1.20220892
91MP0005330_cardiomyopathy1.20076148
92MP0004742_abnormal_vestibular_system1.19406711
93MP0002638_abnormal_pupillary_reflex1.16748935
94MP0000428_abnormal_craniofacial_morphol1.16309623
95MP0000733_abnormal_muscle_development1.16043917
96MP0006072_abnormal_retinal_apoptosis1.14093805
97MP0002066_abnormal_motor_capabilities/c1.11279392
98MP0002972_abnormal_cardiac_muscle1.10856429
99MP0002152_abnormal_brain_morphology1.10436133
100MP0009379_abnormal_foot_pigmentation1.10020011
101MP0005409_darkened_coat_color1.09862397
102MP0001293_anophthalmia1.09830222
103MP0001672_abnormal_embryogenesis/_devel1.09301944
104MP0005380_embryogenesis_phenotype1.09301944
105MP0009703_decreased_birth_body1.09275089
106MP0002009_preneoplasia1.08635279
107MP0005075_abnormal_melanosome_morpholog1.07293044
108MP0001905_abnormal_dopamine_level1.06670310
109MP0000015_abnormal_ear_pigmentation1.06072871
110MP0005171_absent_coat_pigmentation1.04542647
111MP0009672_abnormal_birth_weight1.03196508
112MP0004885_abnormal_endolymph1.02060579
113MP0005266_abnormal_metabolism0.99272838
114MP0004145_abnormal_muscle_electrophysio0.98920687
115MP0002084_abnormal_developmental_patter0.98417528
116MP0008058_abnormal_DNA_repair0.97678701
117MP0001963_abnormal_hearing_physiology0.97477191
118MP0003879_abnormal_hair_cell0.97199108
119MP0001299_abnormal_eye_distance/0.96550588
120MP0001177_atelectasis0.96172349
121MP0000427_abnormal_hair_cycle0.95723664
122MP0000537_abnormal_urethra_morphology0.95336670
123MP0001485_abnormal_pinna_reflex0.95261275
124MP0001697_abnormal_embryo_size0.94920931
125MP0004233_abnormal_muscle_weight0.94778708
126MP0002332_abnormal_exercise_endurance0.94278140
127MP0003943_abnormal_hepatobiliary_system0.93080688
128MP0002971_abnormal_brown_adipose0.92674922
129MP0008789_abnormal_olfactory_epithelium0.92227182
130MP0000350_abnormal_cell_proliferation0.91778205
131MP0002876_abnormal_thyroid_physiology0.91349738
132MP0002108_abnormal_muscle_morphology0.91206928
133MP0000372_irregular_coat_pigmentation0.90961170
134MP0002752_abnormal_somatic_nervous0.90558388
135MP0005367_renal/urinary_system_phenotyp0.90062938
136MP0000516_abnormal_urinary_system0.90062938
137MP0004197_abnormal_fetal_growth/weight/0.89460891
138MP0002909_abnormal_adrenal_gland0.87117740
139MP0003300_gastrointestinal_ulcer0.87086030
140MP0002006_tumorigenesis0.85487803
141MP0003890_abnormal_embryonic-extraembry0.84959305
142MP0001730_embryonic_growth_arrest0.84582508
143MP0004264_abnormal_extraembryonic_tissu0.84025935
144MP0003861_abnormal_nervous_system0.82261362
145MP0003567_abnormal_fetal_cardiomyocyte0.82157599
146MP0003111_abnormal_nucleus_morphology0.82137557
147MP0004858_abnormal_nervous_system0.81632237
148MP0002086_abnormal_extraembryonic_tissu0.81443764
149MP0003937_abnormal_limbs/digits/tail_de0.81324818
150MP0005187_abnormal_penis_morphology0.81239490
151MP0006138_congestive_heart_failure0.80455134
152MP0008007_abnormal_cellular_replicative0.79664891
153MP0002233_abnormal_nose_morphology0.79287939
154MP0002102_abnormal_ear_morphology0.78568642
155MP0003633_abnormal_nervous_system0.77982538
156MP0003868_abnormal_feces_composition0.77466718
157MP0005253_abnormal_eye_physiology0.76793320
158MP0001286_abnormal_eye_development0.76542343
159MP0000266_abnormal_heart_morphology0.75806435
160MP0004142_abnormal_muscle_tone0.75001095
161MP0003631_nervous_system_phenotype0.74205087
162MP0005623_abnormal_meninges_morphology0.74176422
163MP0003935_abnormal_craniofacial_develop0.74148851
164MP0002229_neurodegeneration0.74118953
165MP0002163_abnormal_gland_morphology0.73305150
166MP0003950_abnormal_plasma_membrane0.73244970
167MP0002277_abnormal_respiratory_mucosa0.72820893
168MP0005248_abnormal_Harderian_gland0.72732514
169MP0001544_abnormal_cardiovascular_syste0.72485574
170MP0003183_abnormal_peptide_metabolism0.71932209
171MP0000026_abnormal_inner_ear0.70506428
172MP0004510_myositis0.69217267
173MP0003123_paternal_imprinting0.65966741
174MP0003634_abnormal_glial_cell0.65847084
175MP0000013_abnormal_adipose_tissue0.61359000
176MP0004484_altered_response_of0.61350391
177MP0003632_abnormal_nervous_system0.61045010
178MP0004085_abnormal_heartbeat0.59927718
179MP0002069_abnormal_eating/drinking_beha0.59898957
180MP0003755_abnormal_palate_morphology0.59655569
181MP0001943_abnormal_respiration0.56434477
182MP0005379_endocrine/exocrine_gland_phen0.55754975
183MP0003045_fibrosis0.55619243
184MP0002751_abnormal_autonomic_nervous0.55091000
185MP0002081_perinatal_lethality0.54881431

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.22540878
2Muscle fiber inclusion bodies (HP:0100299)6.13979462
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.92189876
4Focal motor seizures (HP:0011153)5.19147408
5Exercise-induced muscle cramps (HP:0003710)5.13828013
6Subaortic stenosis (HP:0001682)4.66868526
7Abnormality of the left ventricular outflow tract (HP:0011103)4.66868526
8Muscle hypertrophy of the lower extremities (HP:0008968)4.52561532
9Calf muscle hypertrophy (HP:0008981)4.30953478
10Febrile seizures (HP:0002373)4.30463386
11Distal arthrogryposis (HP:0005684)4.22331373
12Epileptic encephalopathy (HP:0200134)4.07608240
13Progressive cerebellar ataxia (HP:0002073)3.83930718
14Focal seizures (HP:0007359)3.83230631
15Exercise-induced myalgia (HP:0003738)3.68095546
16Myokymia (HP:0002411)3.52266223
17Atonic seizures (HP:0010819)3.49552444
18Type 1 muscle fiber predominance (HP:0003803)3.43838117
19Acute myeloid leukemia (HP:0004808)3.43059509
20Rimmed vacuoles (HP:0003805)3.41469010
21Broad-based gait (HP:0002136)3.36779219
22Absence seizures (HP:0002121)3.12143262
23Thyroid carcinoma (HP:0002890)3.11303524
24Gaze-evoked nystagmus (HP:0000640)3.06485157
25Frequent falls (HP:0002359)2.95742797
26Medulloblastoma (HP:0002885)2.89139570
27EMG: myopathic abnormalities (HP:0003458)2.86409479
28Hyporeflexia of lower limbs (HP:0002600)2.85761709
29Drooling (HP:0002307)2.85479533
30Excessive salivation (HP:0003781)2.85479533
31Difficulty running (HP:0009046)2.80929485
32Dialeptic seizures (HP:0011146)2.80924530
33Abnormality of the calf musculature (HP:0001430)2.75118047
34Rhabdomyosarcoma (HP:0002859)2.72414466
35Visual hallucinations (HP:0002367)2.71806395
36Hyperventilation (HP:0002883)2.69375364
37Genetic anticipation (HP:0003743)2.67152617
38Action tremor (HP:0002345)2.66878833
39Protruding tongue (HP:0010808)2.64277941
40Myoglobinuria (HP:0002913)2.62355601
41Bundle branch block (HP:0011710)2.53073482
42Generalized tonic-clonic seizures (HP:0002069)2.51945878
43Absent speech (HP:0001344)2.48238512
44Calcaneovalgus deformity (HP:0001848)2.47156526
45Truncal ataxia (HP:0002078)2.46081803
46Abnormal hair whorl (HP:0010721)2.43055968
47Volvulus (HP:0002580)2.39872693
48Dysdiadochokinesis (HP:0002075)2.35817185
49Inappropriate behavior (HP:0000719)2.34489646
50Deformed tarsal bones (HP:0008119)2.34151185
51Widely spaced teeth (HP:0000687)2.31820377
52Deep philtrum (HP:0002002)2.30276840
53Urinary bladder sphincter dysfunction (HP:0002839)2.29206641
54Cystic hygroma (HP:0000476)2.27963893
55Embryonal renal neoplasm (HP:0011794)2.24518896
56Areflexia of lower limbs (HP:0002522)2.24437172
57Progressive inability to walk (HP:0002505)2.22331067
58Abnormal finger flexion creases (HP:0006143)2.22113521
59Renal cortical cysts (HP:0000803)2.21330022
60Gait imbalance (HP:0002141)2.20925135
61Nephroblastoma (Wilms tumor) (HP:0002667)2.19066713
62Impaired smooth pursuit (HP:0007772)2.18891956
63Dysmetria (HP:0001310)2.18438871
64Amblyopia (HP:0000646)2.15568218
65Pheochromocytoma (HP:0002666)2.15408789
66Supranuclear gaze palsy (HP:0000605)2.14485173
67Abnormality of salivation (HP:0100755)2.14314274
68Neoplasm of the small intestine (HP:0100833)2.12752225
69Abnormality of chromosome stability (HP:0003220)2.12242866
70Rhabdomyolysis (HP:0003201)2.12194428
71Neck muscle weakness (HP:0000467)2.11799797
72Abnormality of the nasal septum (HP:0000419)2.11207420
73Glioma (HP:0009733)2.07169915
74Absent phalangeal crease (HP:0006109)2.05980488
75Curly hair (HP:0002212)2.05353249
76Ankle clonus (HP:0011448)2.05181155
77Poor eye contact (HP:0000817)2.03410924
78Aqueductal stenosis (HP:0002410)2.02931870
79Abnormality of the ischium (HP:0003174)2.02889233
80Neoplasm of the peripheral nervous system (HP:0100007)2.00970258
81Impaired vibration sensation in the lower limbs (HP:0002166)1.99263639
82Fetal akinesia sequence (HP:0001989)1.98948560
83Biliary tract neoplasm (HP:0100574)1.98093151
84Termporal pattern (HP:0011008)1.97314386
85Insidious onset (HP:0003587)1.97314386
86Proximal amyotrophy (HP:0007126)1.97139492
87Abnormality of ocular smooth pursuit (HP:0000617)1.97007201
88Pelvic girdle muscle weakness (HP:0003749)1.96751598
89Absent frontal sinuses (HP:0002688)1.95936756
90Exotropia (HP:0000577)1.95325991
91Medial flaring of the eyebrow (HP:0010747)1.94576003
92Hyperthyroidism (HP:0000836)1.93374852
93Abnormality of the hip-girdle musculature (HP:0001445)1.92940219
94Abnormality of the musculature of the pelvis (HP:0001469)1.92940219
95Abnormal biliary tract morphology (HP:0012440)1.92720057
96Neuroendocrine neoplasm (HP:0100634)1.92254737
97Abnormality of the corticospinal tract (HP:0002492)1.91604574
98Long clavicles (HP:0000890)1.91238995
99Abnormality of binocular vision (HP:0011514)1.91170314
100Diplopia (HP:0000651)1.91170314
101Acute lymphatic leukemia (HP:0006721)1.89236421
102Scanning speech (HP:0002168)1.88364195
103Hyperkalemia (HP:0002153)1.86436666
104Stereotypic behavior (HP:0000733)1.84606653
105Hemiparesis (HP:0001269)1.83294158
106Astrocytoma (HP:0009592)1.82889116
107Abnormality of the astrocytes (HP:0100707)1.82889116
108Limb dystonia (HP:0002451)1.82536671
109Congenital primary aphakia (HP:0007707)1.82265320
110Sudden death (HP:0001699)1.81606220
111Nephrogenic diabetes insipidus (HP:0009806)1.81267499
112Facial diplegia (HP:0001349)1.81056917
113Intestinal atresia (HP:0011100)1.80986730
114Epileptiform EEG discharges (HP:0011182)1.80532390
115Gastroesophageal reflux (HP:0002020)1.79889580
116Depression (HP:0000716)1.79600043
117Papillary thyroid carcinoma (HP:0002895)1.78879662
118Cone-rod dystrophy (HP:0000548)1.78600962
119Muscle fiber splitting (HP:0003555)1.78573308
120Hyperglycemia (HP:0003074)1.78351088
121Cubitus valgus (HP:0002967)1.77937953
122Short chin (HP:0000331)1.76558540
123Abnormality of skeletal muscle fiber size (HP:0012084)1.76195838
124Inability to walk (HP:0002540)1.75988411
125Deeply set eye (HP:0000490)1.75373827
126Colon cancer (HP:0003003)1.75286186
127EMG: neuropathic changes (HP:0003445)1.74926537
128Blue irides (HP:0000635)1.72165038
129Generalized hypopigmentation of hair (HP:0011358)1.71831698
130Chromsome breakage (HP:0040012)1.71589851
131Specific learning disability (HP:0001328)1.71562946
132Abnormality of the labia minora (HP:0012880)1.71530266
133Shoulder girdle muscle weakness (HP:0003547)1.71470412
134Hepatoblastoma (HP:0002884)1.70772546
135Impaired social interactions (HP:0000735)1.70483147
136Abnormal social behavior (HP:0012433)1.70483147
137Abnormality of methionine metabolism (HP:0010901)1.69659131
138Myotonia (HP:0002486)1.69326379
139Urinary urgency (HP:0000012)1.68645416
140Mutism (HP:0002300)1.67990468
141Dysmetric saccades (HP:0000641)1.66963706
142Right ventricular cardiomyopathy (HP:0011663)1.66845842
143Neoplasm of striated muscle (HP:0009728)1.66636390
144Abnormality of incisor morphology (HP:0011063)1.66461476
145EEG with generalized epileptiform discharges (HP:0011198)1.66329465
146Abnormality of midbrain morphology (HP:0002418)1.66022364
147Molar tooth sign on MRI (HP:0002419)1.66022364
148Truncal obesity (HP:0001956)1.65950237
149Papilledema (HP:0001085)1.64485982
150Genital tract atresia (HP:0001827)1.62675557
151Submucous cleft hard palate (HP:0000176)1.61748293
152Abnormality of the calcaneus (HP:0008364)1.59247582
153Degeneration of the lateral corticospinal tracts (HP:0002314)1.58960227
154Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58960227
155Thickened helices (HP:0000391)1.58939751
156Stomach cancer (HP:0012126)1.57793696
157Centrally nucleated skeletal muscle fibers (HP:0003687)1.57383288
158Congenital stationary night blindness (HP:0007642)1.57309143
159Dyschromatopsia (HP:0007641)1.57161038
160Anxiety (HP:0000739)1.56743911
161Gonadal dysgenesis (HP:0000133)1.56281744
162Abnormal pancreas size (HP:0012094)1.54545343
163Overgrowth (HP:0001548)1.54464009
164Central scotoma (HP:0000603)1.53890642
165Autism (HP:0000717)1.53228328
166Neoplasm of the thyroid gland (HP:0100031)1.53088164
167Vaginal atresia (HP:0000148)1.52293346
168Missing ribs (HP:0000921)1.51935868
169Fair hair (HP:0002286)1.51632506
170Hip dysplasia (HP:0001385)1.50076953
171Dilated cardiomyopathy (HP:0001644)1.49968493
172Tubulointerstitial nephritis (HP:0001970)1.49720791
173Transitional cell carcinoma of the bladder (HP:0006740)1.49236217
174Agitation (HP:0000713)1.48973731
175Long nose (HP:0003189)1.48630164
176Obsessive-compulsive behavior (HP:0000722)1.48405326
177Bowel incontinence (HP:0002607)1.47162137
178Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46374762
179Round ear (HP:0100830)1.46344902
180Poor coordination (HP:0002370)1.46331156
181Pulmonic stenosis (HP:0001642)1.46026285
182Open mouth (HP:0000194)1.45800839
183Hypsarrhythmia (HP:0002521)1.44459867
184Spastic gait (HP:0002064)1.44243755
185Abnormality of the frontal sinuses (HP:0002687)1.42790362
186Lower limb muscle weakness (HP:0007340)1.42549973
187Macroorchidism (HP:0000053)1.41506008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.91030708
2MARK14.03368271
3NTRK33.87156194
4EPHA43.43798066
5MAP3K43.05145137
6MAP2K72.97262300
7CASK2.95507743
8MAP3K92.54438461
9PNCK2.30796439
10EIF2AK32.30625242
11SCYL22.27963957
12MINK12.14048742
13RIPK42.10266825
14STK32.05090114
15PLK22.03145969
16PIK3CG2.00720187
17NTRK21.99191733
18MAP3K101.88701935
19STK38L1.85065108
20STK241.77316987
21BMPR21.73969861
22PRPF4B1.73892377
23NEK11.73382787
24CDC71.71719004
25TTN1.71502559
26ACVR1B1.69074489
27SIK21.66403869
28TRIM281.65788497
29MAPK131.61667972
30KSR11.60709888
31PBK1.58848910
32TAF11.58217138
33TRPM71.50052221
34NEK91.49130265
35BRSK21.46048260
36PAK61.45203058
37TGFBR11.43893003
38DAPK21.43094249
39MAP3K121.42515592
40ERBB31.40668563
41MAP2K41.36708389
42TEC1.34771873
43TNIK1.34174017
44SGK21.28663150
45SIK31.27492110
46CDK61.26171805
47MAP3K131.24827691
48BCR1.22627616
49MKNK21.20415767
50CDK51.18766080
51NLK1.17623537
52AKT31.17406974
53CDK191.14530333
54CCNB11.12156715
55SGK2231.09365136
56SGK4941.09365136
57DYRK1A1.09321158
58PASK1.05083766
59CAMKK20.97934479
60FES0.93510634
61CAMK2A0.92919835
62YES10.91250845
63EEF2K0.90502136
64NUAK10.90122572
65FGFR30.89683380
66PINK10.89383842
67GRK50.89377390
68STK380.88936546
69SRPK10.88833677
70MST40.87869303
71SGK30.87826292
72SGK10.86950150
73RPS6KB20.86723778
74CAMK2B0.86287771
75PRKCG0.86109957
76CDC42BPA0.82162374
77UHMK10.81927199
78WNK10.81881072
79CAMK1G0.80688943
80RPS6KA40.80495561
81PKN10.79876452
82STK390.79844848
83CAMKK10.77547637
84NEK60.77243508
85PRKCE0.76496694
86MAP3K20.74697857
87KSR20.73645317
88CDK30.73641672
89PLK40.73485282
90RPS6KB10.72374273
91ATM0.72308218
92STK110.72145342
93WNK30.71053132
94NTRK10.70721985
95FLT30.69048885
96FER0.67954255
97BMPR1B0.67663012
98PLK30.67169192
99DAPK10.66818206
100PHKG10.65587868
101PHKG20.65587868
102LMTK20.64098172
103FGFR10.63363028
104PAK30.63155969
105MAPK100.62516210
106BRD40.61124937
107EIF2AK20.60639566
108MARK20.60417385
109CSNK1G20.56648090
110FGFR20.56229734
111CSF1R0.55033389
112FGR0.55024891
113ZAK0.54938712
114FRK0.54151442
115RAF10.53592615
116MELK0.52871712
117PDK20.52417618
118KIT0.52260654
119MAP3K60.49338754
120NEK20.48878903
121PTK2B0.48432070
122TYRO30.47851193
123CHEK10.47810703
124RET0.47535795
125CAMK1D0.47253104
126MAP3K140.45881279
127TNK20.45556140
128CAMK2D0.44710196
129CSNK1E0.44572583
130RPS6KA30.43696265
131ROCK20.43432823
132WEE10.42995987
133LATS10.42989040
134CDK180.42858465
135OXSR10.42602473
136DYRK20.42442864
137PRKAA20.42402806
138DMPK0.42140592
139PRKG10.42004177
140TSSK60.41858028
141LATS20.41504815
142CDK140.41397888
143EIF2AK10.41288744
144PLK10.41244967
145PRKD30.39904006
146ALK0.39836369
147PRKCB0.39613795
148GSK3B0.39486321
149CDK120.39468418
150MKNK10.39163508
151PIK3CA0.38435559
152FYN0.38429963
153CSNK1A1L0.38196713
154STK40.36908222
155CDK90.36891044
156ATR0.36606130
157MAP3K70.35650295

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.76915552
2Nicotine addiction_Homo sapiens_hsa050333.23822248
3Propanoate metabolism_Homo sapiens_hsa006402.92629821
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32839154
5Olfactory transduction_Homo sapiens_hsa047402.30546230
6Morphine addiction_Homo sapiens_hsa050322.28247175
7Synaptic vesicle cycle_Homo sapiens_hsa047212.22315705
8Glutamatergic synapse_Homo sapiens_hsa047242.20153866
9Circadian entrainment_Homo sapiens_hsa047132.19801745
10Long-term potentiation_Homo sapiens_hsa047202.12994792
11GABAergic synapse_Homo sapiens_hsa047272.11238737
12RNA degradation_Homo sapiens_hsa030181.88866129
13Amphetamine addiction_Homo sapiens_hsa050311.86546314
14RNA transport_Homo sapiens_hsa030131.85513929
15Dopaminergic synapse_Homo sapiens_hsa047281.80171108
16Mismatch repair_Homo sapiens_hsa034301.75322371
17Serotonergic synapse_Homo sapiens_hsa047261.72543545
18Taste transduction_Homo sapiens_hsa047421.69921363
19Glucagon signaling pathway_Homo sapiens_hsa049221.67070850
20Protein export_Homo sapiens_hsa030601.65498742
21Cholinergic synapse_Homo sapiens_hsa047251.62532240
22Long-term depression_Homo sapiens_hsa047301.59343849
23Salivary secretion_Homo sapiens_hsa049701.56740813
24Phototransduction_Homo sapiens_hsa047441.56674311
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50006130
26Renin secretion_Homo sapiens_hsa049241.49377302
27mRNA surveillance pathway_Homo sapiens_hsa030151.48329426
28GnRH signaling pathway_Homo sapiens_hsa049121.40594396
29Nucleotide excision repair_Homo sapiens_hsa034201.40178208
30Systemic lupus erythematosus_Homo sapiens_hsa053221.39914650
31Insulin secretion_Homo sapiens_hsa049111.38602196
32Adherens junction_Homo sapiens_hsa045201.35653157
33Gastric acid secretion_Homo sapiens_hsa049711.34288730
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33108471
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32775970
36Non-small cell lung cancer_Homo sapiens_hsa052231.32697875
37Fanconi anemia pathway_Homo sapiens_hsa034601.31042300
38Renin-angiotensin system_Homo sapiens_hsa046141.30105798
39Axon guidance_Homo sapiens_hsa043601.28233519
40Cell cycle_Homo sapiens_hsa041101.26507938
41Calcium signaling pathway_Homo sapiens_hsa040201.26403590
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24671330
43TGF-beta signaling pathway_Homo sapiens_hsa043501.24164177
44Platelet activation_Homo sapiens_hsa046111.21077550
45Asthma_Homo sapiens_hsa053101.18941431
46Basal transcription factors_Homo sapiens_hsa030221.18864169
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18176642
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18014197
49Collecting duct acid secretion_Homo sapiens_hsa049661.17319004
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17038640
51Type II diabetes mellitus_Homo sapiens_hsa049301.16883357
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16405561
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15686449
54Cocaine addiction_Homo sapiens_hsa050301.14243890
55cAMP signaling pathway_Homo sapiens_hsa040241.12127833
56ErbB signaling pathway_Homo sapiens_hsa040121.08249855
57Lysine degradation_Homo sapiens_hsa003101.07544644
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05111129
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04830012
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04547610
61DNA replication_Homo sapiens_hsa030301.03571384
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00625715
63Gap junction_Homo sapiens_hsa045401.00604428
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00085381
65Insulin signaling pathway_Homo sapiens_hsa049100.98814612
66Estrogen signaling pathway_Homo sapiens_hsa049150.96688555
67Dorso-ventral axis formation_Homo sapiens_hsa043200.96187113
68Thyroid cancer_Homo sapiens_hsa052160.94792217
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93903584
70Oocyte meiosis_Homo sapiens_hsa041140.93644189
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93410606
72Glioma_Homo sapiens_hsa052140.92833455
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92547336
74Insulin resistance_Homo sapiens_hsa049310.92478239
75Prostate cancer_Homo sapiens_hsa052150.90221178
76Selenocompound metabolism_Homo sapiens_hsa004500.90219141
77MAPK signaling pathway_Homo sapiens_hsa040100.89897568
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88972543
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.88227959
80Choline metabolism in cancer_Homo sapiens_hsa052310.86577355
81Melanogenesis_Homo sapiens_hsa049160.86169643
82Type I diabetes mellitus_Homo sapiens_hsa049400.85305325
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84945610
84Circadian rhythm_Homo sapiens_hsa047100.84279552
85MicroRNAs in cancer_Homo sapiens_hsa052060.83798345
86Homologous recombination_Homo sapiens_hsa034400.82268519
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81862206
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.81467006
89Vibrio cholerae infection_Homo sapiens_hsa051100.80186497
90Tight junction_Homo sapiens_hsa045300.79666517
91Dilated cardiomyopathy_Homo sapiens_hsa054140.77339843
92Ras signaling pathway_Homo sapiens_hsa040140.77244549
93B cell receptor signaling pathway_Homo sapiens_hsa046620.76989097
94Chemokine signaling pathway_Homo sapiens_hsa040620.76548706
95Ovarian steroidogenesis_Homo sapiens_hsa049130.74449233
96AMPK signaling pathway_Homo sapiens_hsa041520.74323305
97Autoimmune thyroid disease_Homo sapiens_hsa053200.73481624
98Wnt signaling pathway_Homo sapiens_hsa043100.70405383
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70204602
100Renal cell carcinoma_Homo sapiens_hsa052110.70115242
101Pyruvate metabolism_Homo sapiens_hsa006200.70101939
102Chronic myeloid leukemia_Homo sapiens_hsa052200.70039671
103T cell receptor signaling pathway_Homo sapiens_hsa046600.69403074
104Rheumatoid arthritis_Homo sapiens_hsa053230.68556353
105Small cell lung cancer_Homo sapiens_hsa052220.67817237
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67291719
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66739709
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65845420
109Graft-versus-host disease_Homo sapiens_hsa053320.65209842
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.65135163
111Alcoholism_Homo sapiens_hsa050340.64842755
112* Colorectal cancer_Homo sapiens_hsa052100.63616162
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.62975594
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62651638
115Rap1 signaling pathway_Homo sapiens_hsa040150.62584582
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62050962
117VEGF signaling pathway_Homo sapiens_hsa043700.60592575
118Hippo signaling pathway_Homo sapiens_hsa043900.60294326
119mTOR signaling pathway_Homo sapiens_hsa041500.58530146
120Inositol phosphate metabolism_Homo sapiens_hsa005620.57927243
121Pancreatic secretion_Homo sapiens_hsa049720.57031351
122Endometrial cancer_Homo sapiens_hsa052130.56733868
123Purine metabolism_Homo sapiens_hsa002300.56519595
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.56366720
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55105862
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54712382
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54017560
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53370586
129* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53162831
130African trypanosomiasis_Homo sapiens_hsa051430.52641456
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51104575
132Focal adhesion_Homo sapiens_hsa045100.49556566
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49020535
134Proteoglycans in cancer_Homo sapiens_hsa052050.48790121
135Spliceosome_Homo sapiens_hsa030400.48578696
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48298419
137Ribosome_Homo sapiens_hsa030100.47786567
138FoxO signaling pathway_Homo sapiens_hsa040680.47654990
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47437627
140Thyroid hormone synthesis_Homo sapiens_hsa049180.46753167
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46380051
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46351493
143Cardiac muscle contraction_Homo sapiens_hsa042600.46047323
144Pancreatic cancer_Homo sapiens_hsa052120.42807434
145Prolactin signaling pathway_Homo sapiens_hsa049170.42506046
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42308507
147Melanoma_Homo sapiens_hsa052180.41914795
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41688628
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40648484
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39791332
151Endocytosis_Homo sapiens_hsa041440.39602595
152Allograft rejection_Homo sapiens_hsa053300.38452563
153Salmonella infection_Homo sapiens_hsa051320.37998573

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