APRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.51315344
2maturation of SSU-rRNA (GO:0030490)5.26771710
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.17626971
4DNA deamination (GO:0045006)5.16278922
5formation of translation preinitiation complex (GO:0001731)4.98805326
6viral transcription (GO:0019083)4.97151121
7translational termination (GO:0006415)4.88648560
8ATP synthesis coupled proton transport (GO:0015986)4.72309968
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.72309968
10ribosomal small subunit biogenesis (GO:0042274)4.65595625
11ribosomal large subunit biogenesis (GO:0042273)4.64189428
12regulation of mitochondrial translation (GO:0070129)4.44220005
13translational elongation (GO:0006414)4.43602239
14chaperone-mediated protein transport (GO:0072321)4.42856992
15translational initiation (GO:0006413)4.38485953
16ribonucleoprotein complex biogenesis (GO:0022613)4.27653005
17DNA strand elongation involved in DNA replication (GO:0006271)4.26577305
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.23404588
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19575121
20ribosome assembly (GO:0042255)4.13587408
21* nucleobase biosynthetic process (GO:0046112)4.10372577
22proteasome assembly (GO:0043248)4.08599118
23protein targeting to ER (GO:0045047)4.08290106
24ribosome biogenesis (GO:0042254)4.08112589
25cotranslational protein targeting to membrane (GO:0006613)4.06940386
26DNA strand elongation (GO:0022616)4.04650825
27telomere maintenance via semi-conservative replication (GO:0032201)4.04002550
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95948085
29DNA replication initiation (GO:0006270)3.94825673
30* purine nucleobase biosynthetic process (GO:0009113)3.89446471
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87834857
32cellular protein complex disassembly (GO:0043624)3.87761208
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.87018767
34protein localization to endoplasmic reticulum (GO:0070972)3.86427233
35viral life cycle (GO:0019058)3.86029842
36respiratory electron transport chain (GO:0022904)3.81852017
37rRNA processing (GO:0006364)3.80576859
38DNA replication checkpoint (GO:0000076)3.74303786
39electron transport chain (GO:0022900)3.74086017
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71201308
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71139890
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70503980
43protein targeting to mitochondrion (GO:0006626)3.70461180
44rRNA metabolic process (GO:0016072)3.65699406
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.64330402
46termination of RNA polymerase III transcription (GO:0006386)3.64330402
47protein complex biogenesis (GO:0070271)3.62830504
48translation (GO:0006412)3.62803423
49telomere maintenance via recombination (GO:0000722)3.61298734
50pseudouridine synthesis (GO:0001522)3.58625605
51spliceosomal snRNP assembly (GO:0000387)3.57133661
52mitochondrial respiratory chain complex assembly (GO:0033108)3.56912155
53pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.56333787
54rRNA modification (GO:0000154)3.55309098
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55074797
56negative regulation of ligase activity (GO:0051352)3.55074797
57protein targeting to membrane (GO:0006612)3.53002208
58CTP biosynthetic process (GO:0006241)3.51123550
59CTP metabolic process (GO:0046036)3.51123550
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.48982579
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46877876
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.46866401
63base-excision repair, AP site formation (GO:0006285)3.46653934
64mitotic metaphase plate congression (GO:0007080)3.45516634
65deoxyribonucleotide catabolic process (GO:0009264)3.44085809
66protein complex disassembly (GO:0043241)3.43546899
67establishment of protein localization to mitochondrion (GO:0072655)3.43475467
68GTP biosynthetic process (GO:0006183)3.38857433
69pyrimidine nucleotide catabolic process (GO:0006244)3.38378077
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38321948
71IMP biosynthetic process (GO:0006188)3.38261905
72guanosine-containing compound biosynthetic process (GO:1901070)3.37559198
73deoxyribose phosphate catabolic process (GO:0046386)3.37446412
74UTP biosynthetic process (GO:0006228)3.36836560
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35954012
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35382402
77protein localization to kinetochore (GO:0034501)3.34770049
78GDP-mannose metabolic process (GO:0019673)3.34161233
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31406508
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.31406508
81NADH dehydrogenase complex assembly (GO:0010257)3.31406508
82cellular component biogenesis (GO:0044085)3.31198584
83cytochrome complex assembly (GO:0017004)3.29776236
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29600776
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29600776
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28434861
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28434861
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28434861
89mitotic recombination (GO:0006312)3.27046771
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26341233
91macromolecular complex disassembly (GO:0032984)3.26147783
92mitotic nuclear envelope disassembly (GO:0007077)3.25401845
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24502337
94oxidative phosphorylation (GO:0006119)3.24314527
95signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24139261
96signal transduction involved in DNA damage checkpoint (GO:0072422)3.24139261
97regulation of cellular amino acid metabolic process (GO:0006521)3.23156984
98folic acid metabolic process (GO:0046655)3.23129612
99protein localization to mitochondrion (GO:0070585)3.21636075
100telomere maintenance via telomere lengthening (GO:0010833)3.21535119
101pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.21163717
102signal transduction involved in cell cycle checkpoint (GO:0072395)3.18690176
103respiratory chain complex IV assembly (GO:0008535)3.17773084
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16879279
105folic acid-containing compound biosynthetic process (GO:0009396)3.15963918
106G1/S transition of mitotic cell cycle (GO:0000082)3.14818775
107cell cycle G1/S phase transition (GO:0044843)3.14818775
108transcription-coupled nucleotide-excision repair (GO:0006283)3.14068330
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12321620
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12321620
1117-methylguanosine mRNA capping (GO:0006370)3.12121461
112CENP-A containing nucleosome assembly (GO:0034080)3.11366228
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11154693
114positive regulation of ligase activity (GO:0051351)3.10757736
115nucleobase-containing small molecule interconversion (GO:0015949)3.09831909
116termination of RNA polymerase I transcription (GO:0006363)3.08487218
117nuclear-transcribed mRNA catabolic process (GO:0000956)3.08333364
118transcription from RNA polymerase I promoter (GO:0006360)3.08125424
119DNA unwinding involved in DNA replication (GO:0006268)3.07929407
120protein maturation by protein folding (GO:0022417)3.07025141
121chromatin remodeling at centromere (GO:0031055)3.06284489
1227-methylguanosine RNA capping (GO:0009452)3.05416227
123RNA capping (GO:0036260)3.05416227
124purine deoxyribonucleotide catabolic process (GO:0009155)3.04184190
125nucleotide-excision repair, DNA gap filling (GO:0006297)3.00726866
126transcription elongation from RNA polymerase I promoter (GO:0006362)3.00725594
127UTP metabolic process (GO:0046051)2.99949963
128rRNA methylation (GO:0031167)2.99488531
129DNA replication-dependent nucleosome assembly (GO:0006335)2.97572060
130DNA replication-dependent nucleosome organization (GO:0034723)2.97572060
131nuclear envelope disassembly (GO:0051081)2.97340804
132membrane disassembly (GO:0030397)2.97340804
133IMP metabolic process (GO:0046040)2.94734038
134ribonucleoside triphosphate biosynthetic process (GO:0009201)2.93703387
135pentose metabolic process (GO:0019321)2.93367773
136peptidyl-histidine modification (GO:0018202)2.93318790
137mRNA catabolic process (GO:0006402)2.92111156
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.92040837
139protein localization to chromosome, centromeric region (GO:0071459)2.90399776
140RNA catabolic process (GO:0006401)2.86087127
141spliceosomal complex assembly (GO:0000245)2.85252820
142establishment of protein localization to mitochondrial membrane (GO:0090151)2.85056618
143DNA replication-independent nucleosome organization (GO:0034724)2.81474904
144DNA replication-independent nucleosome assembly (GO:0006336)2.81474904
145positive regulation of cell cycle arrest (GO:0071158)2.80711897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.26069322
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34959349
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07750640
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28847864
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15793094
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.14831414
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.14583636
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.10257938
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06800399
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01893202
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84441158
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82886976
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75927905
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.71122558
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57952664
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52120238
17* XRN2_22483619_ChIP-Seq_HELA_Human2.40724142
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36846248
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29107848
20VDR_23849224_ChIP-Seq_CD4+_Human2.27443569
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26936196
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20463980
23DCP1A_22483619_ChIP-Seq_HELA_Human2.12359538
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11335750
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10077909
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99901610
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97642337
28* GABP_19822575_ChIP-Seq_HepG2_Human1.96025743
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93885795
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92982494
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90710045
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.87346353
33TTF2_22483619_ChIP-Seq_HELA_Human1.87275071
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76320912
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75733183
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74961251
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.74279485
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72054530
39AR_21909140_ChIP-Seq_LNCAP_Human1.71624506
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71320699
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68381686
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67537483
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61021059
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.58798596
45ELK1_19687146_ChIP-ChIP_HELA_Human1.58293268
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55622363
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54826474
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54002534
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.51837037
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49741615
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49130003
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47319004
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.46409147
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45175482
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43342289
56* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38991953
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38325248
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35781636
59MYC_22102868_ChIP-Seq_BL_Human1.34976354
60CIITA_25753668_ChIP-Seq_RAJI_Human1.32322635
61* KDM5A_27292631_Chip-Seq_BREAST_Human1.28570094
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27641319
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.27607633
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25262288
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25042557
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24041021
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23500292
68ZNF263_19887448_ChIP-Seq_K562_Human1.21542142
69TFEB_21752829_ChIP-Seq_HELA_Human1.21195762
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21154701
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20840576
72* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20735825
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.20421473
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16630604
75SPI1_23547873_ChIP-Seq_NB4_Human1.14887716
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.13262925
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11843844
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11821367
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11634123
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.10438897
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09079550
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.08795519
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07758150
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.07700795
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07548634
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07090008
87P68_20966046_ChIP-Seq_HELA_Human1.05132466
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.05029199
89* MAF_26560356_Chip-Seq_TH2_Human1.04658808
90BCL6_27268052_Chip-Seq_Bcells_Human1.00947211
91* LXR_22292898_ChIP-Seq_THP-1_Human0.99983618
92* VDR_21846776_ChIP-Seq_THP-1_Human0.99969648
93* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98890629
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98555575
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97081203
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96662297
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95037527
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93701890
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93525582
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93317224
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93295003
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92919903
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91303409
104BCOR_27268052_Chip-Seq_Bcells_Human0.91070306
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90743585
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90337381
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.90126386
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90083861
109* MAF_26560356_Chip-Seq_TH1_Human0.89607067
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88093755
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.85528660
112MYC_18940864_ChIP-ChIP_HL60_Human0.84854114
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83547016
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83540992
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80823393
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79347161
117* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78539888
118IRF8_21731497_ChIP-ChIP_J774_Mouse0.78120553
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77873353
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77104775
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76851809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67660854
2MP0004957_abnormal_blastocyst_morpholog4.31351311
3MP0003111_abnormal_nucleus_morphology3.95488403
4MP0003077_abnormal_cell_cycle3.58686687
5MP0010094_abnormal_chromosome_stability3.51824945
6MP0008007_abnormal_cellular_replicative2.73859065
7MP0008058_abnormal_DNA_repair2.67728792
8MP0008057_abnormal_DNA_replication2.56737613
9MP0003123_paternal_imprinting2.51690043
10MP0008932_abnormal_embryonic_tissue2.47612840
11MP0002396_abnormal_hematopoietic_system2.33188419
12MP0001730_embryonic_growth_arrest2.16503628
13MP0009333_abnormal_splenocyte_physiolog2.12111240
14MP0003786_premature_aging2.11853232
15MP0000490_abnormal_crypts_of2.02493003
16MP0010352_gastrointestinal_tract_polyps2.01844840
17MP0003718_maternal_effect2.01407610
18MP0002163_abnormal_gland_morphology1.98322476
19MP0001873_stomach_inflammation1.95374456
20MP0000350_abnormal_cell_proliferation1.89470551
21MP0003186_abnormal_redox_activity1.77526481
22MP0010307_abnormal_tumor_latency1.74692675
23MP0001545_abnormal_hematopoietic_system1.63112583
24MP0005397_hematopoietic_system_phenotyp1.63112583
25MP0004808_abnormal_hematopoietic_stem1.56318019
26MP0003567_abnormal_fetal_cardiomyocyte1.55834065
27MP0003806_abnormal_nucleotide_metabolis1.55187780
28MP0001672_abnormal_embryogenesis/_devel1.53880228
29MP0005380_embryogenesis_phenotype1.53880228
30MP0001697_abnormal_embryo_size1.53716663
31MP0005501_abnormal_skin_physiology1.52515228
32MP0002080_prenatal_lethality1.48716482
33MP0000313_abnormal_cell_death1.47620402
34MP0002132_abnormal_respiratory_system1.44587959
35MP0003984_embryonic_growth_retardation1.44247466
36MP0005451_abnormal_body_composition1.41936216
37MP0009379_abnormal_foot_pigmentation1.41613436
38MP0002088_abnormal_embryonic_growth/wei1.41147583
39MP0005075_abnormal_melanosome_morpholog1.39915356
40MP0009840_abnormal_foam_cell1.39111669
41MP0000858_altered_metastatic_potential1.38750388
42MP0002796_impaired_skin_barrier1.36603861
43MP0002019_abnormal_tumor_incidence1.35579163
44MP0001881_abnormal_mammary_gland1.35563037
45MP0000358_abnormal_cell_content/1.32517577
46MP0002086_abnormal_extraembryonic_tissu1.28635466
47MP0006292_abnormal_olfactory_placode1.21371349
48MP0001853_heart_inflammation1.19787181
49MP0003436_decreased_susceptibility_to1.19746414
50MP0003315_abnormal_perineum_morphology1.19593654
51MP0006054_spinal_hemorrhage1.18312752
52MP0000372_irregular_coat_pigmentation1.16622165
53MP0000678_abnormal_parathyroid_gland1.16305871
54MP0004185_abnormal_adipocyte_glucose1.14833438
55MP0005379_endocrine/exocrine_gland_phen1.14250743
56MP0009785_altered_susceptibility_to1.13163364
57MP0002277_abnormal_respiratory_mucosa1.12775413
58MP0002722_abnormal_immune_system1.12527698
59MP0000685_abnormal_immune_system1.11726068
60MP0002085_abnormal_embryonic_tissue1.11700070
61MP0002398_abnormal_bone_marrow1.08119830
62MP0000689_abnormal_spleen_morphology1.08058440
63MP0005023_abnormal_wound_healing1.06812516
64MP0001835_abnormal_antigen_presentation1.06502042
65MP0005083_abnormal_biliary_tract1.04377154
66MP0001919_abnormal_reproductive_system1.03475609
67MP0003221_abnormal_cardiomyocyte_apopto1.01548127
68MP0008995_early_reproductive_senescence1.00368166
69MP0000750_abnormal_muscle_regeneration1.00232530
70* MP0002429_abnormal_blood_cell0.97714640
71MP0001661_extended_life_span0.97486682
72MP0004197_abnormal_fetal_growth/weight/0.96877321
73MP0002084_abnormal_developmental_patter0.95350067
74MP0009697_abnormal_copulation0.90601465
75MP0001790_abnormal_immune_system0.90303299
76MP0005387_immune_system_phenotype0.90303299
77MP0005636_abnormal_mineral_homeostasis0.89887543
78MP0003763_abnormal_thymus_physiology0.89293994
79MP0002405_respiratory_system_inflammati0.89023513
80MP0001346_abnormal_lacrimal_gland0.88910130
81MP0002452_abnormal_antigen_presenting0.88347238
82MP0003705_abnormal_hypodermis_morpholog0.88179859
83MP0008469_abnormal_protein_level0.87670037
84MP0003566_abnormal_cell_adhesion0.87366731
85MP0001542_abnormal_bone_strength0.87133727
86MP0005025_abnormal_response_to0.87028119
87* MP0001845_abnormal_inflammatory_respons0.86842983
88MP0000703_abnormal_thymus_morphology0.86283908
89MP0002148_abnormal_hypersensitivity_rea0.85500809
90MP0005408_hypopigmentation0.85112636
91MP0006035_abnormal_mitochondrial_morpho0.84721440
92MP0008877_abnormal_DNA_methylation0.84205887
93MP0008875_abnormal_xenobiotic_pharmacok0.84172952
94MP0006036_abnormal_mitochondrial_physio0.83839322
95MP0003866_abnormal_defecation0.83645704
96MP0005384_cellular_phenotype0.83581337
97MP0000716_abnormal_immune_system0.83496819
98MP0008873_increased_physiological_sensi0.82651173
99MP0002254_reproductive_system_inflammat0.82403459
100MP0001293_anophthalmia0.82224465
101MP0001819_abnormal_immune_cell0.82188473
102MP0002210_abnormal_sex_determination0.82025738
103MP0003448_altered_tumor_morphology0.81870646
104MP0002420_abnormal_adaptive_immunity0.81811923
105MP0005332_abnormal_amino_acid0.81106250
106MP0010030_abnormal_orbit_morphology0.80865471
107MP0001145_abnormal_male_reproductive0.78674069
108MP0003941_abnormal_skin_development0.78322127
109MP0005319_abnormal_enzyme/_coenzyme0.77607000
110MP0002160_abnormal_reproductive_system0.76985176
111MP0008260_abnormal_autophagy0.76643660
112MP0002723_abnormal_immune_serum0.76450177
113MP0005000_abnormal_immune_tolerance0.76183679
114MP0002419_abnormal_innate_immunity0.75977252
115MP0006082_CNS_inflammation0.74833277
116MP0010155_abnormal_intestine_physiology0.74076399
117MP0001800_abnormal_humoral_immune0.73796462
118MP0005621_abnormal_cell_physiology0.73790729
119MP0009278_abnormal_bone_marrow0.73136536
120MP0001764_abnormal_homeostasis0.71967635
121MP0001727_abnormal_embryo_implantation0.71574747
122MP0000477_abnormal_intestine_morphology0.71444401
123MP0005058_abnormal_lysosome_morphology0.68726807
124MP0005464_abnormal_platelet_physiology0.68295606
125MP0009053_abnormal_anal_canal0.68202764
126MP0005389_reproductive_system_phenotype0.67776488
127MP0000343_altered_response_to0.66502764
128MP0003121_genomic_imprinting0.66268516
129MP0000465_gastrointestinal_hemorrhage0.66110048
130MP0005671_abnormal_response_to0.65482997
131MP0003119_abnormal_digestive_system0.64239826
132MP0000627_abnormal_mammary_gland0.63576594
133MP0001663_abnormal_digestive_system0.63546958
134MP0001915_intracranial_hemorrhage0.63444298
135MP0001119_abnormal_female_reproductive0.62075991

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.26716018
2Abnormal number of erythroid precursors (HP:0012131)4.98478127
3Reticulocytopenia (HP:0001896)4.89360528
4Acute necrotizing encephalopathy (HP:0006965)4.78498965
5Abnormal mitochondria in muscle tissue (HP:0008316)4.74400446
6Birth length less than 3rd percentile (HP:0003561)4.71048410
7Acute encephalopathy (HP:0006846)4.40794793
8Increased intramyocellular lipid droplets (HP:0012240)4.28216417
9Breast hypoplasia (HP:0003187)4.26910831
10Renal Fanconi syndrome (HP:0001994)4.09950627
11Increased muscle lipid content (HP:0009058)3.92096876
12Macrocytic anemia (HP:0001972)3.85156967
13Rough bone trabeculation (HP:0100670)3.81331924
14Progressive macrocephaly (HP:0004481)3.68365435
15Oral leukoplakia (HP:0002745)3.61034465
16Multiple enchondromatosis (HP:0005701)3.55043944
17Pallor (HP:0000980)3.47209388
18Aplastic anemia (HP:0001915)3.45849352
19Abnormality of the anterior horn cell (HP:0006802)3.44551705
20Degeneration of anterior horn cells (HP:0002398)3.44551705
21Cerebral edema (HP:0002181)3.32822377
22Trismus (HP:0000211)3.23607733
23Lactic acidosis (HP:0003128)3.22956117
24Selective tooth agenesis (HP:0001592)3.22824299
25Testicular atrophy (HP:0000029)3.16053786
26Microretrognathia (HP:0000308)3.08150920
27Carpal bone hypoplasia (HP:0001498)3.06723557
28Exercise intolerance (HP:0003546)3.00790348
29Cerebral hypomyelination (HP:0006808)2.97548284
30Thrombocytosis (HP:0001894)2.94421002
31Patellar aplasia (HP:0006443)2.87727592
32Abnormal trabecular bone morphology (HP:0100671)2.82401901
33Colon cancer (HP:0003003)2.78352068
34Aplasia/Hypoplasia of the patella (HP:0006498)2.76597321
35Respiratory failure (HP:0002878)2.75479158
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68662199
37Abnormal protein N-linked glycosylation (HP:0012347)2.68662199
38Abnormal protein glycosylation (HP:0012346)2.68662199
39Abnormal glycosylation (HP:0012345)2.68662199
40Poor head control (HP:0002421)2.55915255
41Impulsivity (HP:0100710)2.54664800
42Premature graying of hair (HP:0002216)2.53889410
43Agnosia (HP:0010524)2.53437161
44Absent thumb (HP:0009777)2.52391229
4511 pairs of ribs (HP:0000878)2.50440772
46Premature ovarian failure (HP:0008209)2.47264905
47Secondary amenorrhea (HP:0000869)2.44632537
48Sparse eyelashes (HP:0000653)2.42728301
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38040984
50Petechiae (HP:0000967)2.37858617
51Meckel diverticulum (HP:0002245)2.35069968
52Abnormality of the umbilical cord (HP:0010881)2.32825148
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31381951
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31381951
55Lethargy (HP:0001254)2.30852344
56Bone marrow hypocellularity (HP:0005528)2.30465022
57Cleft eyelid (HP:0000625)2.30136031
58Type I transferrin isoform profile (HP:0003642)2.28930897
59Abnormality of renal resorption (HP:0011038)2.28833572
60Abnormality of the preputium (HP:0100587)2.28788644
61Ragged-red muscle fibers (HP:0003200)2.27334521
62Neoplasm of the pancreas (HP:0002894)2.25056491
63Personality changes (HP:0000751)2.25026956
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24441663
65Increased hepatocellular lipid droplets (HP:0006565)2.22567931
66Increased serum lactate (HP:0002151)2.20217361
67Chromsome breakage (HP:0040012)2.20060832
68Cellular immunodeficiency (HP:0005374)2.19871822
69Abnormality of the ileum (HP:0001549)2.19349690
70Dicarboxylic aciduria (HP:0003215)2.17600770
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17600770
72Progressive muscle weakness (HP:0003323)2.14686744
73Exertional dyspnea (HP:0002875)2.14625213
74Glossoptosis (HP:0000162)2.13403480
75Myelodysplasia (HP:0002863)2.13144862
76Pancytopenia (HP:0001876)2.11443141
77Megaloblastic anemia (HP:0001889)2.10718710
78Entropion (HP:0000621)2.07822350
79Absent radius (HP:0003974)2.06617334
80Leukodystrophy (HP:0002415)2.03083088
81Opisthotonus (HP:0002179)2.02827879
82Tracheoesophageal fistula (HP:0002575)2.02473754
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02004521
84Slender long bone (HP:0003100)2.01517524
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01322709
86Abnormality of reticulocytes (HP:0004312)1.99507230
87IgM deficiency (HP:0002850)1.99218241
88Optic disc pallor (HP:0000543)1.96510289
89Abnormality of chromosome stability (HP:0003220)1.95789568
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95761112
91Horseshoe kidney (HP:0000085)1.94356665
92Hepatocellular necrosis (HP:0001404)1.92541020
93Atrophy/Degeneration involving motor neurons (HP:0007373)1.92404905
94Nausea (HP:0002018)1.91553866
95Elevated erythrocyte sedimentation rate (HP:0003565)1.91153563
96Lipid accumulation in hepatocytes (HP:0006561)1.91124087
97Methylmalonic aciduria (HP:0012120)1.91119610
98Hypoplasia of the pons (HP:0012110)1.90378091
99Microvesicular hepatic steatosis (HP:0001414)1.89878472
100Squamous cell carcinoma (HP:0002860)1.89027504
101Spinal muscular atrophy (HP:0007269)1.88631911
102Abnormality of methionine metabolism (HP:0010901)1.88346225
103Abnormality of glycolysis (HP:0004366)1.87637547
104Increased serum pyruvate (HP:0003542)1.87637547
105Absent forearm bone (HP:0003953)1.87200244
106Aplasia involving forearm bones (HP:0009822)1.87200244
107Hypertensive crisis (HP:0100735)1.87185724
108Increased CSF lactate (HP:0002490)1.86974533
109Pustule (HP:0200039)1.85938983
110Reduced antithrombin III activity (HP:0001976)1.83425346
111Generalized aminoaciduria (HP:0002909)1.83338344
112Emotional lability (HP:0000712)1.82688507
113Ureteral duplication (HP:0000073)1.80561825
114Duodenal stenosis (HP:0100867)1.80535790
115Small intestinal stenosis (HP:0012848)1.80535790
116Abnormality of pyrimidine metabolism (HP:0004353)1.79496306
117Hepatic necrosis (HP:0002605)1.78601909
118Atresia of the external auditory canal (HP:0000413)1.78147222
119Hyperphosphaturia (HP:0003109)1.78056352
120CNS demyelination (HP:0007305)1.78002097
121Triphalangeal thumb (HP:0001199)1.77996221
122Muscle fiber atrophy (HP:0100295)1.77518006
1233-Methylglutaconic aciduria (HP:0003535)1.77196588
124Chronic obstructive pulmonary disease (HP:0006510)1.76930739
125Obstructive lung disease (HP:0006536)1.76930739
126Mitochondrial inheritance (HP:0001427)1.76194455
127Tongue fasciculations (HP:0001308)1.76096615
128Paralysis (HP:0003470)1.75985581
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.73615859
130Glycosuria (HP:0003076)1.73497461
131Abnormality of urine glucose concentration (HP:0011016)1.73497461
132Abnormality of the pons (HP:0007361)1.73420639
133Recurrent abscess formation (HP:0002722)1.73409155
134Death in infancy (HP:0001522)1.73406003
135Postnatal microcephaly (HP:0005484)1.73320630
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72867787
137Abnormality of T cell physiology (HP:0011840)1.71514150
138Congenital, generalized hypertrichosis (HP:0004540)1.71334755
139Respiratory difficulties (HP:0002880)1.71062798
140Hepatosplenomegaly (HP:0001433)1.70431884
141Seborrheic dermatitis (HP:0001051)1.70032717
142Muscle fibrillation (HP:0010546)1.69760418
143Neutropenia (HP:0001875)1.68647558
144Increased serum ferritin (HP:0003281)1.65907299
145Hypergonadotropic hypogonadism (HP:0000815)1.63943572
146Progressive microcephaly (HP:0000253)1.63200771
147IgG deficiency (HP:0004315)1.61985151
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61565397
149Panhypogammaglobulinemia (HP:0003139)1.59936876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.15708359
2BUB14.82240497
3NME24.31727056
4WEE14.27296661
5EIF2AK12.98800794
6PIM22.66097798
7STK162.56523389
8TSSK62.46468052
9NEK22.21440377
10PLK42.12550408
11EIF2AK32.08165715
12TESK22.07835066
13CDC72.06411159
14SMG11.97719461
15SRPK11.92421288
16EPHA21.91727839
17BRSK21.84879232
18ACVR1B1.80099674
19RPS6KA41.69241057
20PLK11.63765974
21TESK11.56283614
22MST41.55628442
23VRK11.53449799
24NEK11.52238702
25TTK1.48916194
26KDR1.47932642
27CDK71.46460294
28PAK41.43883551
29RPS6KB21.41200531
30DYRK31.39759269
31AURKB1.38168376
32TLK11.36871064
33PASK1.33892210
34ARAF1.31525382
35TRIB31.29495147
36MAP3K81.26505296
37MAP3K111.26428717
38BLK1.20395198
39TAF11.18468741
40BRAF1.17928543
41NUAK11.16833965
42AURKA1.15777966
43MKNK11.14154598
44TGFBR11.12849374
45BRSK11.09432210
46PLK31.08941330
47LRRK21.06635916
48PIM11.06231147
49ATR1.03033177
50ZAK1.01516959
51MAP2K31.00133932
52NME10.98922798
53SCYL20.98513100
54MUSK0.95538984
55CDK40.93333244
56MAP4K10.91739843
57PKN20.91342754
58PAK10.90592747
59DAPK10.88103972
60FLT30.86732603
61CCNB10.86628214
62CHEK20.85811920
63TAOK20.83747687
64STK100.83608574
65TXK0.82568286
66ABL20.80639733
67EIF2AK20.76561491
68MKNK20.75989206
69MAP3K30.74342880
70EEF2K0.74054084
71IRAK30.73764600
72ILK0.73672417
73MAP2K20.70070444
74ZAP700.69439145
75CHEK10.68556193
76CSNK2A10.68545991
77CDK190.67644400
78CSNK2A20.64897545
79MAP3K120.63346561
80PRKCI0.62783357
81PBK0.60831416
82STK40.60566902
83LIMK10.58544429
84DYRK20.55262067
85CDK80.53170081
86CSNK1G30.52596187
87MAPKAPK30.48152662
88BCKDK0.47754519
89CDK20.46746236
90BTK0.46667639
91IKBKB0.46577738
92RPS6KA50.46509572
93ALK0.46114252
94AKT30.44361639
95TEC0.43250048
96IKBKE0.43005558
97ITK0.42306528
98TBK10.41970097
99PDK40.41920244
100PDK30.41920244
101NEK90.40360867
102MAP4K20.39873802
103KIT0.39838723
104GRK60.39310288
105RAF10.39310099
106LATS20.39205788
107MAP3K100.39157824
108SIK10.38744845
109TYK20.36828660
110ERN10.36402097
111MATK0.35387653
112PRKG20.35260692
113DAPK30.34889675
114JAK30.34499199
115PDK20.33324467
116AKT20.33007101
117IRAK40.32697361
118IRAK20.32438694
119ATM0.32188136
120CSNK1G10.30606746
121MAPKAPK50.28207412
122LYN0.27036696
123MAPKAPK20.24187609
124PRKCD0.24127223

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60744959
2Proteasome_Homo sapiens_hsa030504.36755471
3DNA replication_Homo sapiens_hsa030304.27743861
4RNA polymerase_Homo sapiens_hsa030203.75034450
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59718093
6Mismatch repair_Homo sapiens_hsa034303.39521823
7Spliceosome_Homo sapiens_hsa030402.87204877
8RNA transport_Homo sapiens_hsa030132.80567445
9Pyrimidine metabolism_Homo sapiens_hsa002402.78872828
10Base excision repair_Homo sapiens_hsa034102.65031468
11Nucleotide excision repair_Homo sapiens_hsa034202.52451433
12Homologous recombination_Homo sapiens_hsa034402.48352088
13Cell cycle_Homo sapiens_hsa041102.08861050
14One carbon pool by folate_Homo sapiens_hsa006702.07590822
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05091363
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72200462
17Basal transcription factors_Homo sapiens_hsa030221.55382356
18Fanconi anemia pathway_Homo sapiens_hsa034601.52621520
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50332398
20p53 signaling pathway_Homo sapiens_hsa041151.47664138
21RNA degradation_Homo sapiens_hsa030181.45654372
22Vitamin B6 metabolism_Homo sapiens_hsa007501.42705012
23* Purine metabolism_Homo sapiens_hsa002301.38500415
24Pentose phosphate pathway_Homo sapiens_hsa000301.37085978
25Folate biosynthesis_Homo sapiens_hsa007901.36037472
26Fatty acid elongation_Homo sapiens_hsa000621.28125366
27Epstein-Barr virus infection_Homo sapiens_hsa051691.25022660
28Sulfur relay system_Homo sapiens_hsa041221.15901909
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15340860
30Non-homologous end-joining_Homo sapiens_hsa034501.14096354
31Pyruvate metabolism_Homo sapiens_hsa006201.03336811
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.01944571
33Huntingtons disease_Homo sapiens_hsa050161.01684113
34Parkinsons disease_Homo sapiens_hsa050121.01128462
35Oxidative phosphorylation_Homo sapiens_hsa001900.97688063
36Legionellosis_Homo sapiens_hsa051340.95135033
37Antigen processing and presentation_Homo sapiens_hsa046120.95028825
38mRNA surveillance pathway_Homo sapiens_hsa030150.95006288
39Sulfur metabolism_Homo sapiens_hsa009200.94508142
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.93891273
41Biosynthesis of amino acids_Homo sapiens_hsa012300.93874658
42Protein export_Homo sapiens_hsa030600.93408791
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91184155
44Systemic lupus erythematosus_Homo sapiens_hsa053220.88425364
45Fructose and mannose metabolism_Homo sapiens_hsa000510.84881883
46Glutathione metabolism_Homo sapiens_hsa004800.82993573
47Cardiac muscle contraction_Homo sapiens_hsa042600.80163299
48Galactose metabolism_Homo sapiens_hsa000520.78236993
49Herpes simplex infection_Homo sapiens_hsa051680.77075918
50Viral carcinogenesis_Homo sapiens_hsa052030.69821952
51Carbon metabolism_Homo sapiens_hsa012000.64767738
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63098152
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62616321
54Apoptosis_Homo sapiens_hsa042100.61478848
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61471580
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61443948
57Autoimmune thyroid disease_Homo sapiens_hsa053200.60998160
58Shigellosis_Homo sapiens_hsa051310.60085012
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54835534
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52902342
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52348958
62Selenocompound metabolism_Homo sapiens_hsa004500.52198242
63N-Glycan biosynthesis_Homo sapiens_hsa005100.50380361
64Peroxisome_Homo sapiens_hsa041460.48703073
65HTLV-I infection_Homo sapiens_hsa051660.48621860
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48201420
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47892980
68Renin-angiotensin system_Homo sapiens_hsa046140.47361455
69Oocyte meiosis_Homo sapiens_hsa041140.45953909
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45947413
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45648833
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.45495087
73Thyroid cancer_Homo sapiens_hsa052160.45223693
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41563327
75Tyrosine metabolism_Homo sapiens_hsa003500.41002779
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40872293
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40548092
78Regulation of autophagy_Homo sapiens_hsa041400.39146006
79Small cell lung cancer_Homo sapiens_hsa052220.38652616
80Other glycan degradation_Homo sapiens_hsa005110.38297040
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37373059
82* Metabolic pathways_Homo sapiens_hsa011000.37366806
83Measles_Homo sapiens_hsa051620.36960257
84Leishmaniasis_Homo sapiens_hsa051400.36777224
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36593501
86Alzheimers disease_Homo sapiens_hsa050100.36350765
87HIF-1 signaling pathway_Homo sapiens_hsa040660.35663450
88Bladder cancer_Homo sapiens_hsa052190.33520047
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33325498
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32999560
91Type I diabetes mellitus_Homo sapiens_hsa049400.32408475
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32369437
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.31876106
94Asthma_Homo sapiens_hsa053100.31744322
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30704971
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.30107607
97Arachidonic acid metabolism_Homo sapiens_hsa005900.29467615
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29127260
99Arginine and proline metabolism_Homo sapiens_hsa003300.29057784
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28880731
101Phenylalanine metabolism_Homo sapiens_hsa003600.28372471
102Propanoate metabolism_Homo sapiens_hsa006400.27626821
103Hepatitis B_Homo sapiens_hsa051610.27438719
104Influenza A_Homo sapiens_hsa051640.26471560
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25657886
106Hematopoietic cell lineage_Homo sapiens_hsa046400.25055654
107Allograft rejection_Homo sapiens_hsa053300.23319377
108Vitamin digestion and absorption_Homo sapiens_hsa049770.21778376
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21280975
110Primary immunodeficiency_Homo sapiens_hsa053400.20858277
111Rheumatoid arthritis_Homo sapiens_hsa053230.20671901
112Collecting duct acid secretion_Homo sapiens_hsa049660.20149966
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19793404
114Lysosome_Homo sapiens_hsa041420.19258347
115Viral myocarditis_Homo sapiens_hsa054160.17705243
116Phagosome_Homo sapiens_hsa041450.15285466
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15149973
118Fatty acid metabolism_Homo sapiens_hsa012120.14926116
119Alcoholism_Homo sapiens_hsa050340.14709369
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.14432388
121Vibrio cholerae infection_Homo sapiens_hsa051100.14193596
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13839819
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.13026932
124MicroRNAs in cancer_Homo sapiens_hsa052060.12766158
125Graft-versus-host disease_Homo sapiens_hsa053320.11709758

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