APTX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)4.18577568
2establishment of integrated proviral latency (GO:0075713)4.12615445
3long-chain fatty acid biosynthetic process (GO:0042759)4.10794771
4regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.09981874
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.09132356
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.08025447
7chaperone-mediated protein transport (GO:0072321)4.05652401
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03492697
9axonemal dynein complex assembly (GO:0070286)4.00355611
10anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.84471486
11protein neddylation (GO:0045116)3.78424960
12rRNA methylation (GO:0031167)3.75086021
13proteasome assembly (GO:0043248)3.66834669
14positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61714265
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61567801
16neuron cell-cell adhesion (GO:0007158)3.59275504
17cullin deneddylation (GO:0010388)3.59162639
18motile cilium assembly (GO:0044458)3.58807724
19ribosome assembly (GO:0042255)3.57599493
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56948074
21signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56948074
22signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56948074
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55109820
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55109820
25presynaptic membrane assembly (GO:0097105)3.51784404
26protein complex biogenesis (GO:0070271)3.51283423
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.47518827
28NADH dehydrogenase complex assembly (GO:0010257)3.47518827
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47518827
30establishment of viral latency (GO:0019043)3.47023762
31positive regulation of ligase activity (GO:0051351)3.45685283
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44617012
33ribosomal large subunit biogenesis (GO:0042273)3.43402183
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42153102
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.42153102
36chromatin remodeling at centromere (GO:0031055)3.41984624
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.41881140
38CENP-A containing nucleosome assembly (GO:0034080)3.37694838
39positive regulation of protein homodimerization activity (GO:0090073)3.37231154
40protein localization to cilium (GO:0061512)3.36550154
41ATP synthesis coupled proton transport (GO:0015986)3.33770993
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33770993
43startle response (GO:0001964)3.29509309
44synapsis (GO:0007129)3.28960639
45regulation of ubiquitin-protein transferase activity (GO:0051438)3.27854344
46protein deneddylation (GO:0000338)3.27187926
47acrosome reaction (GO:0007340)3.26731025
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25975824
49ribosomal small subunit assembly (GO:0000028)3.25420498
50presynaptic membrane organization (GO:0097090)3.22335188
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.20228899
52termination of RNA polymerase III transcription (GO:0006386)3.20228899
53microtubule depolymerization (GO:0007019)3.20211364
54pseudouridine synthesis (GO:0001522)3.19131767
55regulation of cilium movement (GO:0003352)3.16975934
56* DNA catabolic process, exonucleolytic (GO:0000738)3.16296413
57epithelial cilium movement (GO:0003351)3.16251641
58DNA replication checkpoint (GO:0000076)3.15992461
59regulation of ligase activity (GO:0051340)3.15804458
60DNA damage response, detection of DNA damage (GO:0042769)3.09920513
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08052381
62respiratory electron transport chain (GO:0022904)3.07001583
63electron transport chain (GO:0022900)3.04865800
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04400400
65cellular component biogenesis (GO:0044085)3.04256521
66maturation of 5.8S rRNA (GO:0000460)3.04216301
67protein targeting to mitochondrion (GO:0006626)3.04007077
68mitochondrial respiratory chain complex assembly (GO:0033108)3.03375972
69ribosome biogenesis (GO:0042254)3.01594504
70sperm motility (GO:0030317)3.01370252
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01302464
72DNA deamination (GO:0045006)3.01040837
73positive regulation of mitochondrial fission (GO:0090141)3.00767583
74amino acid activation (GO:0043038)2.98855234
75tRNA aminoacylation (GO:0043039)2.98855234
76intraciliary transport (GO:0042073)2.98327331
77histone exchange (GO:0043486)2.98287811
78microtubule severing (GO:0051013)2.97173851
79tRNA aminoacylation for protein translation (GO:0006418)2.96479157
80purine nucleobase biosynthetic process (GO:0009113)2.96149887
81ubiquinone metabolic process (GO:0006743)2.96131167
82quinone biosynthetic process (GO:1901663)2.96061555
83ubiquinone biosynthetic process (GO:0006744)2.96061555
84DNA double-strand break processing (GO:0000729)2.94705641
85ATP hydrolysis coupled proton transport (GO:0015991)2.93400425
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93400425
87branched-chain amino acid catabolic process (GO:0009083)2.92871201
88water-soluble vitamin biosynthetic process (GO:0042364)2.92412472
89protein localization to synapse (GO:0035418)2.91805744
90spliceosomal snRNP assembly (GO:0000387)2.91216487
91protein localization to mitochondrion (GO:0070585)2.90943719
92establishment of protein localization to mitochondrion (GO:0072655)2.90395987
93* DNA ligation (GO:0006266)2.90329809
94telomere maintenance via semi-conservative replication (GO:0032201)2.89332227
95ribonucleoprotein complex biogenesis (GO:0022613)2.88941775
96nonmotile primary cilium assembly (GO:0035058)2.88917033
97postsynaptic membrane organization (GO:0001941)2.88517857
98rRNA processing (GO:0006364)2.87913682
99oxidative phosphorylation (GO:0006119)2.87486486
100fatty acid elongation (GO:0030497)2.86929338
101cilium movement (GO:0003341)2.84249602
102GTP biosynthetic process (GO:0006183)2.82111231
103GMP metabolic process (GO:0046037)2.81861988
104urinary tract smooth muscle contraction (GO:0014848)2.81664592
105inner mitochondrial membrane organization (GO:0007007)2.81342941
106regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.81151359
107negative regulation of protein ubiquitination (GO:0031397)2.80951623
108calcium ion-dependent exocytosis (GO:0017156)2.80432430
109replication fork processing (GO:0031297)2.80019898
110protein K11-linked ubiquitination (GO:0070979)2.79919361
111protein-cofactor linkage (GO:0018065)2.79478177
112rRNA metabolic process (GO:0016072)2.78999859
113regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78804912
114DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.76766418
115deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76604747
116cilium or flagellum-dependent cell motility (GO:0001539)2.76018742
117translation (GO:0006412)2.75925976
118DNA strand elongation involved in DNA replication (GO:0006271)2.74857229
119guanosine-containing compound biosynthetic process (GO:1901070)2.74282942
120tRNA metabolic process (GO:0006399)2.74213742
121organelle disassembly (GO:1903008)2.73812605
122mannosylation (GO:0097502)2.73792203
123mechanosensory behavior (GO:0007638)2.73651891
124transcription-coupled nucleotide-excision repair (GO:0006283)2.73445598
125regulation of cellular amine metabolic process (GO:0033238)2.72289609
126neuronal action potential propagation (GO:0019227)2.71618093
127mitotic metaphase plate congression (GO:0007080)2.71492113
1287-methylguanosine RNA capping (GO:0009452)2.71359501
129RNA capping (GO:0036260)2.71359501
130vocalization behavior (GO:0071625)2.70128318
131positive regulation of cell cycle arrest (GO:0071158)2.69596329
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68702145
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.68702145
134transferrin transport (GO:0033572)2.67819712
135cilium assembly (GO:0042384)2.66852508
136multicellular organism reproduction (GO:0032504)2.63225722
137cytochrome complex assembly (GO:0017004)2.62341792
138establishment of mitochondrion localization (GO:0051654)2.60310716
139regulation of dopamine metabolic process (GO:0042053)2.60226076
140regulation of catecholamine metabolic process (GO:0042069)2.60226076
1417-methylguanosine mRNA capping (GO:0006370)2.59617923
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58260908
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58260908
144respiratory chain complex IV assembly (GO:0008535)2.57365682
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.57152561
146neurotransmitter uptake (GO:0001504)2.56655492
147protein polyglutamylation (GO:0018095)2.56632864
148synaptic vesicle exocytosis (GO:0016079)2.56295767
149regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56142537
150regulation of cellular amino acid metabolic process (GO:0006521)2.55178620
151cilium organization (GO:0044782)2.55124746
152synaptic transmission, glutamatergic (GO:0035249)2.54776823
153cilium morphogenesis (GO:0060271)2.52603089
154rhodopsin mediated signaling pathway (GO:0016056)2.52545948
155detection of light stimulus involved in visual perception (GO:0050908)2.51241558
156detection of light stimulus involved in sensory perception (GO:0050962)2.51241558
157neuron-neuron synaptic transmission (GO:0007270)2.51014286
158negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50430804
159negative regulation of ligase activity (GO:0051352)2.50430804
160neurotransmitter-gated ion channel clustering (GO:0072578)2.50289500
161viral mRNA export from host cell nucleus (GO:0046784)2.50270480
162axoneme assembly (GO:0035082)2.48051579
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44949171
164gamma-aminobutyric acid signaling pathway (GO:0007214)2.44612230
165regulation of mitochondrial translation (GO:0070129)2.44527721
166isoprenoid biosynthetic process (GO:0008299)2.44449723
167hydrogen ion transmembrane transport (GO:1902600)2.44343126
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43756805
169microtubule polymerization or depolymerization (GO:0031109)2.43508396
170response to redox state (GO:0051775)2.43300351
171ionotropic glutamate receptor signaling pathway (GO:0035235)2.41475350
172ferric iron transport (GO:0015682)2.39294101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88836404
2GBX2_23144817_ChIP-Seq_PC3_Human3.86934701
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.53063527
4E2F7_22180533_ChIP-Seq_HELA_Human3.38445021
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04575944
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94590783
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93054316
8ELK1_19687146_ChIP-ChIP_HELA_Human2.92915935
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82196457
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71498176
11VDR_23849224_ChIP-Seq_CD4+_Human2.67752263
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56302198
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46321918
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43948754
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43841090
16DCP1A_22483619_ChIP-Seq_HELA_Human2.43347535
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42980990
18TAF15_26573619_Chip-Seq_HEK293_Human2.42418196
19FOXP3_21729870_ChIP-Seq_TREG_Human2.40890465
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40205603
21* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36544770
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31289950
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19681359
24VDR_22108803_ChIP-Seq_LS180_Human2.18220778
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15928499
26GABP_19822575_ChIP-Seq_HepG2_Human2.14839496
27* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08643889
28* XRN2_22483619_ChIP-Seq_HELA_Human2.07401206
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06775135
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06711397
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04175889
32FUS_26573619_Chip-Seq_HEK293_Human2.03119166
33CBX2_27304074_Chip-Seq_ESCs_Mouse2.01895184
34TTF2_22483619_ChIP-Seq_HELA_Human2.01356008
35IGF1R_20145208_ChIP-Seq_DFB_Human1.98886197
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98863127
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.98355993
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98155068
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94322731
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86120028
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84642119
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84175801
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83674210
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82180225
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80842214
46* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76298692
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74503761
48REST_21632747_ChIP-Seq_MESCs_Mouse1.73296813
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.73292866
50ER_23166858_ChIP-Seq_MCF-7_Human1.73226568
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71531138
52MYC_18940864_ChIP-ChIP_HL60_Human1.71134298
53* GABP_17652178_ChIP-ChIP_JURKAT_Human1.70957910
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70748334
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70332418
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69750664
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65028049
58P300_19829295_ChIP-Seq_ESCs_Human1.64760658
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.62869995
60* RNF2_27304074_Chip-Seq_NSC_Mouse1.62840285
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62769081
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57436788
63* KDM5A_27292631_Chip-Seq_BREAST_Human1.55479246
64* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54266319
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53559057
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47769816
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46375376
68* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.45788701
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44713337
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44171860
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.43128730
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.41398315
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.41243426
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41233774
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40797876
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.40085632
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.38686600
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38590986
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38144862
80* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36911566
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.36039438
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34646273
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34117310
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34110231
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33321226
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33150715
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33060595
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31290140
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31121822
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30577814
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.30215894
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29679247
93* E2F1_18555785_Chip-Seq_ESCs_Mouse1.28565528
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.28243309
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.27672601
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26466814
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.26089586
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24774321
99* ELK1_22589737_ChIP-Seq_MCF10A_Human1.24690188
100P53_22387025_ChIP-Seq_ESCs_Mouse1.24616521
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24378167
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22927211
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22124292
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21998661
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20940808
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.20867906
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20827999
108EWS_26573619_Chip-Seq_HEK293_Human1.19542695
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18186869
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17114812
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.17087799
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.17065300
113* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16770962
114AR_21909140_ChIP-Seq_LNCAP_Human1.15452777
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15053302
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15053302
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13955507
118SOX9_26525672_Chip-Seq_HEART_Mouse1.13892232
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.13397019
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.13276510
121P300_18555785_Chip-Seq_ESCs_Mouse1.13255623
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12592893
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.12507711
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11572001
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09837103
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09789998
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09659633
128JUN_21703547_ChIP-Seq_K562_Human1.09229424
129ZNF274_21170338_ChIP-Seq_K562_Hela1.09174212
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09170094
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.09129463
132CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08865745
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07815078
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07417887
135AR_25329375_ChIP-Seq_VCAP_Human1.07269872
136SOX2_16153702_ChIP-ChIP_HESCs_Human1.05481038
137RNF2_27304074_Chip-Seq_ESCs_Mouse1.05303014
138RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05192881
139NMYC_18555785_Chip-Seq_ESCs_Mouse1.04774986
140PIAS1_25552417_ChIP-Seq_VCAP_Human1.04013467
141MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01357239
142ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01195258
143ETS1_20019798_ChIP-Seq_JURKAT_Human1.00615435
144TFEB_21752829_ChIP-Seq_HELA_Human0.99873899
145AR_21572438_ChIP-Seq_LNCaP_Human0.99804623
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99389250
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98967046
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98861492
149* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98796637
150IRF1_19129219_ChIP-ChIP_H3396_Human0.98523481
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98439830
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98108214
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.96593393
154NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96588115
155CIITA_25753668_ChIP-Seq_RAJI_Human0.95005173
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93104422
157* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92928064
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92297655
159NOTCH1_21737748_ChIP-Seq_TLL_Human0.90508187
160* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89006647
161TP53_22573176_ChIP-Seq_HFKS_Human0.86466010
162* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84075184
163TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83271399
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82026842
165TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78517311
166* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.69971559
167PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69458686
168CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.67970418
169ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66503470
170ELF5_23300383_ChIP-Seq_T47D_Human0.66073960
171DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.65020044
172TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63632740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008058_abnormal_DNA_repair4.57456371
2MP0003880_abnormal_central_pattern3.77703728
3MP0003693_abnormal_embryo_hatching3.67827782
4MP0010094_abnormal_chromosome_stability3.47641142
5MP0004957_abnormal_blastocyst_morpholog3.32602937
6MP0003111_abnormal_nucleus_morphology3.00146810
7MP0003806_abnormal_nucleotide_metabolis2.80261371
8MP0003786_premature_aging2.76081385
9MP0008932_abnormal_embryonic_tissue2.75882677
10MP0001529_abnormal_vocalization2.65076383
11MP0005410_abnormal_fertilization2.58411651
12MP0001968_abnormal_touch/_nociception2.52620145
13MP0001984_abnormal_olfaction2.52606511
14MP0004270_analgesia2.50212217
15MP0001986_abnormal_taste_sensitivity2.47064196
16MP0008007_abnormal_cellular_replicative2.45580002
17MP0002638_abnormal_pupillary_reflex2.45065929
18MP0003186_abnormal_redox_activity2.43766853
19MP0002736_abnormal_nociception_after2.43300031
20MP0002876_abnormal_thyroid_physiology2.40181392
21MP0009046_muscle_twitch2.35421679
22MP0001188_hyperpigmentation2.33853504
23MP0004859_abnormal_synaptic_plasticity2.33584051
24MP0006292_abnormal_olfactory_placode2.31893358
25MP0003077_abnormal_cell_cycle2.31426279
26MP0002735_abnormal_chemical_nociception2.23324787
27MP0002734_abnormal_mechanical_nocicepti2.22262161
28MP0002272_abnormal_nervous_system2.18759474
29MP0009745_abnormal_behavioral_response2.18622501
30MP0003635_abnormal_synaptic_transmissio2.16108751
31MP0006276_abnormal_autonomic_nervous2.15589169
32MP0006035_abnormal_mitochondrial_morpho2.14922118
33MP0001486_abnormal_startle_reflex2.10086635
34MP0005423_abnormal_somatic_nervous2.02677076
35MP0002064_seizures1.91867232
36MP0002063_abnormal_learning/memory/cond1.91704408
37MP0003136_yellow_coat_color1.90396382
38MP0006036_abnormal_mitochondrial_physio1.89813696
39MP0002572_abnormal_emotion/affect_behav1.89038465
40MP0009697_abnormal_copulation1.85102005
41MP0001905_abnormal_dopamine_level1.84917646
42MP0000372_irregular_coat_pigmentation1.81152081
43MP0008877_abnormal_DNA_methylation1.72877472
44MP0008260_abnormal_autophagy1.72334078
45MP0000778_abnormal_nervous_system1.71651694
46MP0005551_abnormal_eye_electrophysiolog1.66644199
47MP0001293_anophthalmia1.65589867
48MP0000566_synostosis1.65528374
49MP0002067_abnormal_sensory_capabilities1.63774176
50MP0002234_abnormal_pharynx_morphology1.63618701
51MP0000358_abnormal_cell_content/1.62875789
52MP0002184_abnormal_innervation1.60210235
53MP0003950_abnormal_plasma_membrane1.53659227
54MP0010386_abnormal_urinary_bladder1.53551613
55MP0005409_darkened_coat_color1.52314673
56MP0005171_absent_coat_pigmentation1.50475635
57MP0001970_abnormal_pain_threshold1.49492590
58MP0003941_abnormal_skin_development1.49337887
59MP0005646_abnormal_pituitary_gland1.44411166
60MP0005499_abnormal_olfactory_system1.42970239
61MP0005394_taste/olfaction_phenotype1.42970239
62MP0004142_abnormal_muscle_tone1.42284904
63MP0005645_abnormal_hypothalamus_physiol1.41864768
64MP0000647_abnormal_sebaceous_gland1.41177647
65MP0002822_catalepsy1.39647104
66MP0003787_abnormal_imprinting1.39359968
67MP0001145_abnormal_male_reproductive1.35917899
68MP0000653_abnormal_sex_gland1.33932994
69MP0002733_abnormal_thermal_nociception1.30633210
70MP0001764_abnormal_homeostasis1.30434628
71MP0003698_abnormal_male_reproductive1.29369372
72MP0002837_dystrophic_cardiac_calcinosis1.28439574
73MP0003567_abnormal_fetal_cardiomyocyte1.27471133
74MP0008995_early_reproductive_senescence1.26007195
75MP0003937_abnormal_limbs/digits/tail_de1.25470140
76MP0008789_abnormal_olfactory_epithelium1.24958106
77MP0001440_abnormal_grooming_behavior1.23330368
78MP0005389_reproductive_system_phenotype1.23043251
79MP0004742_abnormal_vestibular_system1.22865779
80MP0003879_abnormal_hair_cell1.21610548
81MP0004147_increased_porphyrin_level1.20718735
82MP0008057_abnormal_DNA_replication1.20606814
83MP0002557_abnormal_social/conspecific_i1.19535625
84MP0002163_abnormal_gland_morphology1.19327917
85MP0004145_abnormal_muscle_electrophysio1.18543024
86MP0006072_abnormal_retinal_apoptosis1.15713253
87MP0001501_abnormal_sleep_pattern1.13512666
88MP0003122_maternal_imprinting1.12524569
89MP0001485_abnormal_pinna_reflex1.12410143
90MP0002938_white_spotting1.11405263
91MP0001730_embryonic_growth_arrest1.11374765
92MP0002882_abnormal_neuron_morphology1.08158665
93MP0002233_abnormal_nose_morphology1.07637801
94MP0002752_abnormal_somatic_nervous1.07045488
95MP0005386_behavior/neurological_phenoty1.05965688
96MP0004924_abnormal_behavior1.05965688
97MP0005253_abnormal_eye_physiology1.03788114
98MP0003315_abnormal_perineum_morphology1.03727997
99MP0001697_abnormal_embryo_size1.03597693
100MP0001963_abnormal_hearing_physiology1.01220709
101MP0004381_abnormal_hair_follicle1.01153187
102MP0009379_abnormal_foot_pigmentation1.01069365
103MP0002332_abnormal_exercise_endurance1.00842793
104MP0003329_amyloid_beta_deposits0.99997657
105MP0002102_abnormal_ear_morphology0.97588551
106MP0002160_abnormal_reproductive_system0.97166781
107MP0000681_abnormal_thyroid_gland0.97094933
108MP0002084_abnormal_developmental_patter0.96886451
109MP0004811_abnormal_neuron_physiology0.96575710
110MP0003718_maternal_effect0.95976412
111MP0004043_abnormal_pH_regulation0.95319376
112MP0000350_abnormal_cell_proliferation0.94810834
113MP0000955_abnormal_spinal_cord0.94732317
114MP0000313_abnormal_cell_death0.94508334
115MP0001929_abnormal_gametogenesis0.93936386
116MP0000026_abnormal_inner_ear0.90949016
117MP0002085_abnormal_embryonic_tissue0.90721909
118MP0002066_abnormal_motor_capabilities/c0.89841182
119MP0001919_abnormal_reproductive_system0.89287209
120MP0001177_atelectasis0.88786811
121MP0002751_abnormal_autonomic_nervous0.87962298
122MP0002080_prenatal_lethality0.87726537
123MP0002229_neurodegeneration0.87019171
124MP0001119_abnormal_female_reproductive0.86919681
125MP0000015_abnormal_ear_pigmentation0.86326382
126MP0001286_abnormal_eye_development0.85788063
127MP0003011_delayed_dark_adaptation0.85225580
128MP0008872_abnormal_physiological_respon0.84829679
129MP0006054_spinal_hemorrhage0.83211875
130MP0005380_embryogenesis_phenotype0.82055396
131MP0001672_abnormal_embryogenesis/_devel0.82055396
132MP0003878_abnormal_ear_physiology0.81680080
133MP0005377_hearing/vestibular/ear_phenot0.81680080
134MP0000631_abnormal_neuroendocrine_gland0.80929253
135MP0008569_lethality_at_weaning0.80353628
136MP0003121_genomic_imprinting0.78334688
137MP0002697_abnormal_eye_size0.78206045
138MP0008875_abnormal_xenobiotic_pharmacok0.77626743
139MP0005379_endocrine/exocrine_gland_phen0.76585117
140MP0005501_abnormal_skin_physiology0.75332949
141MP0002161_abnormal_fertility/fecundity0.75174284
142MP0005395_other_phenotype0.74500857
143MP0005367_renal/urinary_system_phenotyp0.74493695
144MP0000516_abnormal_urinary_system0.74493695
145MP0005332_abnormal_amino_acid0.74289835
146MP0000049_abnormal_middle_ear0.73195651
147MP0004133_heterotaxia0.72724587
148MP0002210_abnormal_sex_determination0.72237977
149MP0003646_muscle_fatigue0.71379362
150MP0005220_abnormal_exocrine_pancreas0.71356446
151MP0002090_abnormal_vision0.70543661
152MP0005391_vision/eye_phenotype0.70347520
153MP0004215_abnormal_myocardial_fiber0.69780561
154MP0001542_abnormal_bone_strength0.68180256
155MP0001348_abnormal_lacrimal_gland0.67674940
156MP0009780_abnormal_chondrocyte_physiolo0.67529646
157MP0003119_abnormal_digestive_system0.67416761
158MP0005084_abnormal_gallbladder_morpholo0.67267739
159MP0003890_abnormal_embryonic-extraembry0.67267229
160MP0005636_abnormal_mineral_homeostasis0.67021414
161MP0002111_abnormal_tail_morphology0.66774855
162MP0005187_abnormal_penis_morphology0.66378951
163MP0003984_embryonic_growth_retardation0.66088351
164MP0010030_abnormal_orbit_morphology0.64157911

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.49608280
2Absent/shortened dynein arms (HP:0200106)5.49608280
3Focal motor seizures (HP:0011153)4.14438416
4Acute necrotizing encephalopathy (HP:0006965)4.02941057
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.92315650
6Abnormal respiratory motile cilium morphology (HP:0005938)3.84130826
7Abnormal respiratory epithelium morphology (HP:0012253)3.84130826
8Abnormal ciliary motility (HP:0012262)3.82278970
9Abnormal respiratory motile cilium physiology (HP:0012261)3.81211750
10Lipid accumulation in hepatocytes (HP:0006561)3.80470652
11Metaphyseal dysplasia (HP:0100255)3.72153369
12Pancreatic fibrosis (HP:0100732)3.66133039
13Abnormal mitochondria in muscle tissue (HP:0008316)3.55822140
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53820011
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53820011
16Abnormal hair whorl (HP:0010721)3.47684938
17* Medial flaring of the eyebrow (HP:0010747)3.38794228
18Gait imbalance (HP:0002141)3.31152771
19Mitochondrial inheritance (HP:0001427)3.17655623
20Parakeratosis (HP:0001036)3.15903511
21Congenital primary aphakia (HP:0007707)3.14337777
22Febrile seizures (HP:0002373)3.12697732
23Progressive macrocephaly (HP:0004481)3.12232726
24Microvesicular hepatic steatosis (HP:0001414)3.08184996
25Nephrogenic diabetes insipidus (HP:0009806)3.01635526
26Genital tract atresia (HP:0001827)2.93486953
27Acute encephalopathy (HP:0006846)2.90716939
28True hermaphroditism (HP:0010459)2.89243534
29Increased CSF lactate (HP:0002490)2.85873822
30Epileptic encephalopathy (HP:0200134)2.82390149
31Increased intramyocellular lipid droplets (HP:0012240)2.80681755
32Birth length less than 3rd percentile (HP:0003561)2.80477524
33Respiratory failure (HP:0002878)2.77091342
34Hyperventilation (HP:0002883)2.70947771
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68370206
36Atonic seizures (HP:0010819)2.68319866
37Increased serum pyruvate (HP:0003542)2.65846160
38Abnormality of glycolysis (HP:0004366)2.65846160
39Vaginal atresia (HP:0000148)2.65667930
40Short tibia (HP:0005736)2.60457464
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.55077317
42Rhinitis (HP:0012384)2.53816986
43Reticulocytopenia (HP:0001896)2.50389337
44Hyperglycinemia (HP:0002154)2.50281488
45Hepatocellular necrosis (HP:0001404)2.49746206
46Lethargy (HP:0001254)2.46711431
47Optic disc pallor (HP:0000543)2.43009289
48Colon cancer (HP:0003003)2.41643646
49Abnormality of alanine metabolism (HP:0010916)2.40797913
50Hyperalaninemia (HP:0003348)2.40797913
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40797913
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40417714
53Abnormal protein N-linked glycosylation (HP:0012347)2.40417714
54Abnormal protein glycosylation (HP:0012346)2.40417714
55Abnormal glycosylation (HP:0012345)2.40417714
56Polyphagia (HP:0002591)2.37305691
57Abnormality of serum amino acid levels (HP:0003112)2.36681793
58Methylmalonic acidemia (HP:0002912)2.36264483
59Abnormality of methionine metabolism (HP:0010901)2.34612080
60Pancreatic cysts (HP:0001737)2.32032086
61Poor coordination (HP:0002370)2.26723064
62Abnormality of the labia minora (HP:0012880)2.24157879
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21064767
64Myokymia (HP:0002411)2.20530647
65Increased muscle lipid content (HP:0009058)2.19537291
66Methylmalonic aciduria (HP:0012120)2.18408485
673-Methylglutaconic aciduria (HP:0003535)2.17895751
68Oral leukoplakia (HP:0002745)2.14814441
69Broad-based gait (HP:0002136)2.14806844
70Abnormal number of erythroid precursors (HP:0012131)2.14480920
71Respiratory difficulties (HP:0002880)2.14027128
72Abnormality of renal resorption (HP:0011038)2.12557090
73Aplasia/Hypoplasia of the lens (HP:0008063)2.11148453
74Leukodystrophy (HP:0002415)2.09503687
75CNS demyelination (HP:0007305)2.08707334
76Hypoglycemic coma (HP:0001325)2.08206482
77Degeneration of anterior horn cells (HP:0002398)2.07878574
78Abnormality of the anterior horn cell (HP:0006802)2.07878574
79Abnormality of cells of the erythroid lineage (HP:0012130)2.06249786
80Nephronophthisis (HP:0000090)2.05561322
81Neuroendocrine neoplasm (HP:0100634)2.04350778
82Exertional dyspnea (HP:0002875)2.04143738
83Poor suck (HP:0002033)2.03679987
84Tubulointerstitial nephritis (HP:0001970)2.00413671
85Abnormality of the preputium (HP:0100587)1.98557826
86Focal seizures (HP:0007359)1.98048200
87Hyperinsulinemic hypoglycemia (HP:0000825)1.96266135
88Progressive cerebellar ataxia (HP:0002073)1.95780874
89Abnormality of midbrain morphology (HP:0002418)1.95463517
90Molar tooth sign on MRI (HP:0002419)1.95463517
91Hepatic necrosis (HP:0002605)1.94606311
92Lactic acidosis (HP:0003128)1.93078897
93Postaxial foot polydactyly (HP:0001830)1.92708666
94Hypothermia (HP:0002045)1.91410657
95Dialeptic seizures (HP:0011146)1.90102228
96CNS hypomyelination (HP:0003429)1.88387603
97Esotropia (HP:0000565)1.87417877
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87366374
99Absence seizures (HP:0002121)1.87304221
100Exercise intolerance (HP:0003546)1.85629513
101Meckel diverticulum (HP:0002245)1.84720961
102Squamous cell carcinoma (HP:0002860)1.83351113
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.83256779
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.82609929
105Absent eyebrow (HP:0002223)1.82438452
106Exercise-induced muscle cramps (HP:0003710)1.81933611
107Aplastic anemia (HP:0001915)1.81881036
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81715255
109Specific learning disability (HP:0001328)1.81360105
110Postaxial hand polydactyly (HP:0001162)1.80737468
111Multiple enchondromatosis (HP:0005701)1.80693192
112Macrocytic anemia (HP:0001972)1.80560013
113Abnormality of the ileum (HP:0001549)1.79631500
114Congenital ichthyosiform erythroderma (HP:0007431)1.77977398
115Glycosuria (HP:0003076)1.76862374
116Abnormality of urine glucose concentration (HP:0011016)1.76862374
117Horseshoe kidney (HP:0000085)1.75875978
118Infertility (HP:0000789)1.75309874
119Absent thumb (HP:0009777)1.75061726
120Inability to walk (HP:0002540)1.74107498
121Neurofibrillary tangles (HP:0002185)1.73823713
122Abnormality of chromosome stability (HP:0003220)1.73798880
123Emotional lability (HP:0000712)1.73577056
124Stenosis of the external auditory canal (HP:0000402)1.73165139
125Increased serum lactate (HP:0002151)1.71814762
126Renal cortical cysts (HP:0000803)1.70026984
127Male pseudohermaphroditism (HP:0000037)1.69709448
128Abnormality of glycine metabolism (HP:0010895)1.69433059
129Abnormality of serine family amino acid metabolism (HP:0010894)1.69433059
130Reduced antithrombin III activity (HP:0001976)1.69077587
131Chromsome breakage (HP:0040012)1.68326914
132Brushfield spots (HP:0001088)1.67940807
133Preaxial hand polydactyly (HP:0001177)1.67704496
134Cerebral edema (HP:0002181)1.67553810
135Increased hepatocellular lipid droplets (HP:0006565)1.67544377
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.67156748
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67156748
138Broad foot (HP:0001769)1.67117185
139Pancytopenia (HP:0001876)1.67029202
140Decreased central vision (HP:0007663)1.66447292
141Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66198204
142Short femoral neck (HP:0100864)1.66155103
143Postnatal microcephaly (HP:0005484)1.65627069
144Patchy hypopigmentation of hair (HP:0011365)1.65578080
145Sloping forehead (HP:0000340)1.65423151
146Pheochromocytoma (HP:0002666)1.65332182
147Hyperglycinuria (HP:0003108)1.65292394
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65289944
149X-linked dominant inheritance (HP:0001423)1.64517058
150Renal Fanconi syndrome (HP:0001994)1.62711039
151Type I transferrin isoform profile (HP:0003642)1.62295876
152Optic nerve hypoplasia (HP:0000609)1.61700886
153Adrenal hypoplasia (HP:0000835)1.60782009
154Retinal dysplasia (HP:0007973)1.60573932
155Split foot (HP:0001839)1.60570236
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.60532312
157Astigmatism (HP:0000483)1.58465159
158Fetal akinesia sequence (HP:0001989)1.58128858
159Occipital encephalocele (HP:0002085)1.57565264
160Poor speech (HP:0002465)1.56266988
161Cerebral hypomyelination (HP:0006808)1.55973677
162Median cleft lip (HP:0000161)1.55403198
163Aganglionic megacolon (HP:0002251)1.54262905
164White forelock (HP:0002211)1.54149270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.79010990
2VRK23.37521824
3TRIM282.78130700
4MAP4K22.64317293
5STK162.58171927
6MAP2K72.52035037
7SIK32.48545804
8SRPK12.21187216
9MAP3K122.08989959
10BCR2.08921142
11NEK12.08919192
12MARK12.04642702
13TTK2.04161075
14NUAK11.96885517
15WNK31.92841304
16CDC71.89957382
17TLK11.83241611
18TNIK1.82984284
19NTRK31.80592787
20MUSK1.79286541
21PDK31.73107934
22PDK41.73107934
23NME21.71201824
24MAPK131.69586456
25TAF11.64943984
26AKT31.63060003
27BMPR21.62075831
28BMPR1B1.61112848
29PLK21.60900169
30BCKDK1.59992288
31MKNK21.50126546
32BRSK21.49201862
33PLK11.44701169
34CCNB11.43676604
35STK391.43365231
36PBK1.39915514
37TSSK61.37540933
38PINK11.33114270
39WEE11.28978095
40MKNK11.28338872
41EPHA41.26016557
42NME11.24055217
43ERBB31.20831546
44BUB11.20586811
45DYRK21.20083392
46OXSR11.20010671
47NEK61.19851522
48MAP3K41.17237214
49CDK191.17218272
50PNCK1.11785312
51PLK41.11735187
52GRK71.11058969
53DYRK1A1.09862062
54NTRK21.08792184
55EIF2AK11.08552566
56PDK21.06519125
57EIF2AK31.03920781
58PRPF4B1.02509633
59MAPKAPK51.02421993
60ADRBK21.02354621
61ZAK1.01930896
62PKN11.00443478
63MINK10.99054160
64SGK4940.97941758
65SGK2230.97941758
66ARAF0.97467051
67BRSK10.94416252
68SGK20.89303334
69MYLK0.88518507
70PRKCE0.87418439
71CSNK1G10.86570542
72INSRR0.86533627
73MST40.86163396
74ATR0.85413681
75CDK30.84206526
76CAMK2A0.83945547
77AURKB0.83440853
78SIK20.81362629
79YES10.80607348
80FRK0.80213339
81BRAF0.80156358
82CDK80.78760658
83UHMK10.77233326
84FLT30.76437864
85* PRKCG0.76417986
86WNK40.74058252
87CAMK2B0.74050780
88GRK50.73239658
89EIF2AK20.72736130
90CDK50.72366970
91RIPK40.71528413
92AURKA0.70392553
93SCYL20.68471038
94NEK20.66515083
95STK38L0.65404205
96CSNK2A10.63192245
97CHEK20.62727411
98TXK0.61821823
99DAPK10.61756357
100ATM0.61045450
101GRK10.59123155
102CSNK2A20.58452557
103CDK180.57955202
104VRK10.57009724
105MAP3K90.56874648
106KDR0.56435533
107IRAK20.55225386
108CSNK1G30.54610465
109STK30.54230406
110RPS6KA50.54174450
111CDK140.51971449
112CHEK10.51926030
113PLK30.51487660
114CAMK2D0.50776515
115PIM20.50396321
116TNK20.49623939
117PTK2B0.49336359
118IRAK10.48927675
119CDK150.48132933
120CSNK1G20.46513771
121LIMK10.46114244
122ERBB40.45980836
123CDK11A0.45372870
124PIK3CA0.44895796
125PRKCI0.44582117
126TGFBR10.44342313
127PASK0.44076554
128OBSCN0.42765415
129MARK20.42254474
130TESK20.41211942
131CAMK2G0.40168596
132STK40.39770199
133ABL20.39572178
134DYRK30.39468608
135PRKACA0.39288073
136PHKG10.37256545
137PHKG20.37256545
138ACVR1B0.34857242
139IRAK40.34734592
140CSNK1E0.34569867
141ADRBK10.34454723
142TESK10.34295918
143CDK90.33478627
144CSNK1A1L0.33114759
145WNK10.32818274
146CDK70.31531541
147ALK0.29551758
148PAK40.29458416

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.96922500
2Proteasome_Homo sapiens_hsa030503.36424764
3Parkinsons disease_Homo sapiens_hsa050123.31061864
4Mismatch repair_Homo sapiens_hsa034302.89170444
5Nicotine addiction_Homo sapiens_hsa050332.83725587
6DNA replication_Homo sapiens_hsa030302.81621003
7Collecting duct acid secretion_Homo sapiens_hsa049662.70285666
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53651386
9Huntingtons disease_Homo sapiens_hsa050162.53565604
10RNA polymerase_Homo sapiens_hsa030202.51489021
11Alzheimers disease_Homo sapiens_hsa050102.49890379
12Synaptic vesicle cycle_Homo sapiens_hsa047212.45322736
13Protein export_Homo sapiens_hsa030602.38735989
14Non-homologous end-joining_Homo sapiens_hsa034502.31856849
15Phototransduction_Homo sapiens_hsa047442.28461176
16SNARE interactions in vesicular transport_Homo sapiens_hsa041302.13589859
17Base excision repair_Homo sapiens_hsa034102.13564970
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89488758
19Morphine addiction_Homo sapiens_hsa050321.76265164
20GABAergic synapse_Homo sapiens_hsa047271.71013475
21Fatty acid elongation_Homo sapiens_hsa000621.70984323
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70598339
23Cardiac muscle contraction_Homo sapiens_hsa042601.69965336
24Olfactory transduction_Homo sapiens_hsa047401.66878005
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66443734
26One carbon pool by folate_Homo sapiens_hsa006701.66431948
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65340564
28Circadian entrainment_Homo sapiens_hsa047131.61820056
29Vibrio cholerae infection_Homo sapiens_hsa051101.53859751
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53300892
31Serotonergic synapse_Homo sapiens_hsa047261.46675754
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45617188
33Glutamatergic synapse_Homo sapiens_hsa047241.44977170
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.44367053
35Basal transcription factors_Homo sapiens_hsa030221.40553225
36Taste transduction_Homo sapiens_hsa047421.40453676
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33898602
38Steroid biosynthesis_Homo sapiens_hsa001001.33693650
39Regulation of autophagy_Homo sapiens_hsa041401.33220791
40Sphingolipid metabolism_Homo sapiens_hsa006001.29792628
41Ribosome_Homo sapiens_hsa030101.27076288
42Vitamin B6 metabolism_Homo sapiens_hsa007501.27013784
43Purine metabolism_Homo sapiens_hsa002301.20966367
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18674923
45Cell cycle_Homo sapiens_hsa041101.17091347
46Rheumatoid arthritis_Homo sapiens_hsa053231.15810636
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11218143
48Amphetamine addiction_Homo sapiens_hsa050311.10091878
49Autoimmune thyroid disease_Homo sapiens_hsa053201.08240387
50Carbon metabolism_Homo sapiens_hsa012001.08122353
51Selenocompound metabolism_Homo sapiens_hsa004501.07601625
52Dopaminergic synapse_Homo sapiens_hsa047281.05487714
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04379739
54Type I diabetes mellitus_Homo sapiens_hsa049401.04375487
55Biosynthesis of amino acids_Homo sapiens_hsa012301.03081916
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01302431
57Peroxisome_Homo sapiens_hsa041461.01257267
58Ether lipid metabolism_Homo sapiens_hsa005651.00424201
59Sulfur metabolism_Homo sapiens_hsa009201.00081050
60Insulin secretion_Homo sapiens_hsa049110.99171671
61Calcium signaling pathway_Homo sapiens_hsa040200.98420794
62Allograft rejection_Homo sapiens_hsa053300.96847580
63Glutathione metabolism_Homo sapiens_hsa004800.96374109
64Folate biosynthesis_Homo sapiens_hsa007900.95232762
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94163185
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93727310
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92620607
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92204594
69Spliceosome_Homo sapiens_hsa030400.88165372
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85989501
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84830766
72Phagosome_Homo sapiens_hsa041450.84192577
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84086789
74Renin secretion_Homo sapiens_hsa049240.83795168
75Cholinergic synapse_Homo sapiens_hsa047250.83180778
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83148234
77p53 signaling pathway_Homo sapiens_hsa041150.81780542
78Pyrimidine metabolism_Homo sapiens_hsa002400.79227272
79Oocyte meiosis_Homo sapiens_hsa041140.73897163
80Salivary secretion_Homo sapiens_hsa049700.73703041
81Fanconi anemia pathway_Homo sapiens_hsa034600.73108036
82N-Glycan biosynthesis_Homo sapiens_hsa005100.71750220
83Long-term potentiation_Homo sapiens_hsa047200.69357613
84Graft-versus-host disease_Homo sapiens_hsa053320.68953016
85Long-term depression_Homo sapiens_hsa047300.67771658
86Cocaine addiction_Homo sapiens_hsa050300.65844809
87Homologous recombination_Homo sapiens_hsa034400.65616883
88Axon guidance_Homo sapiens_hsa043600.64787246
89Linoleic acid metabolism_Homo sapiens_hsa005910.63470530
90Sulfur relay system_Homo sapiens_hsa041220.63097560
91Pyruvate metabolism_Homo sapiens_hsa006200.63023220
92Arginine and proline metabolism_Homo sapiens_hsa003300.62635924
93Fatty acid metabolism_Homo sapiens_hsa012120.62493332
94Arachidonic acid metabolism_Homo sapiens_hsa005900.61387702
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61096541
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60838418
97RNA degradation_Homo sapiens_hsa030180.59104222
98beta-Alanine metabolism_Homo sapiens_hsa004100.57332044
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56376264
100Ovarian steroidogenesis_Homo sapiens_hsa049130.55908790
101Metabolic pathways_Homo sapiens_hsa011000.55666701
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54315538
103Circadian rhythm_Homo sapiens_hsa047100.54154332
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.51329084
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.49489765
106Oxytocin signaling pathway_Homo sapiens_hsa049210.49114315
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48767670
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47088864
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43564314
110Fatty acid degradation_Homo sapiens_hsa000710.42476246
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42085661
112Pentose phosphate pathway_Homo sapiens_hsa000300.41707562
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41164330
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41060175
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.40305972
116Caffeine metabolism_Homo sapiens_hsa002320.39791717
117Tryptophan metabolism_Homo sapiens_hsa003800.39693827
118Asthma_Homo sapiens_hsa053100.38939627
119Gastric acid secretion_Homo sapiens_hsa049710.37554594
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36227499
121Retinol metabolism_Homo sapiens_hsa008300.36191897
122RNA transport_Homo sapiens_hsa030130.35698691
123cAMP signaling pathway_Homo sapiens_hsa040240.34966502
124Epstein-Barr virus infection_Homo sapiens_hsa051690.34740901
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33870774
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.33732865
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33434805
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33327530
129mRNA surveillance pathway_Homo sapiens_hsa030150.32286769
130Chemical carcinogenesis_Homo sapiens_hsa052040.31560064
131Fructose and mannose metabolism_Homo sapiens_hsa000510.31235391
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30767988
133Propanoate metabolism_Homo sapiens_hsa006400.30766153
134Vitamin digestion and absorption_Homo sapiens_hsa049770.30529354
135Nitrogen metabolism_Homo sapiens_hsa009100.30328899
136Gap junction_Homo sapiens_hsa045400.29931901
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29725073
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29604215
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28203426
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27139121
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26976580
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25782309
143Alcoholism_Homo sapiens_hsa050340.25267864
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24035312
145Galactose metabolism_Homo sapiens_hsa000520.22222309
146Hedgehog signaling pathway_Homo sapiens_hsa043400.22010755
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.20953670
148Dilated cardiomyopathy_Homo sapiens_hsa054140.20489813
149Nucleotide excision repair_Homo sapiens_hsa034200.20030867
150Butanoate metabolism_Homo sapiens_hsa006500.18441169
151Tyrosine metabolism_Homo sapiens_hsa003500.15111706
152Arginine biosynthesis_Homo sapiens_hsa002200.15005985

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