AQP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.49528176
2lysine catabolic process (GO:0006554)6.49528176
3drug transmembrane transport (GO:0006855)4.81134954
4urate metabolic process (GO:0046415)4.70975506
5cysteine metabolic process (GO:0006534)4.65813898
62-oxoglutarate metabolic process (GO:0006103)4.59156602
7valine metabolic process (GO:0006573)4.58919998
8surfactant homeostasis (GO:0043129)4.53316452
9aspartate family amino acid catabolic process (GO:0009068)4.39711921
10fatty acid beta-oxidation (GO:0006635)4.39600181
11glyoxylate metabolic process (GO:0046487)4.32729378
12peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.29207704
13fatty acid transmembrane transport (GO:1902001)4.24171703
14tricarboxylic acid metabolic process (GO:0072350)4.18285854
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16113969
16L-phenylalanine metabolic process (GO:0006558)4.11536722
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.11536722
18fatty acid oxidation (GO:0019395)4.08312667
19acetyl-CoA metabolic process (GO:0006084)4.07181655
20quaternary ammonium group transport (GO:0015697)4.05639667
21short-chain fatty acid metabolic process (GO:0046459)4.03487174
22L-phenylalanine catabolic process (GO:0006559)4.00383410
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.00383410
24carnitine transport (GO:0015879)4.00227236
25amino-acid betaine transport (GO:0015838)4.00227236
26lipid oxidation (GO:0034440)3.99385236
27drug transport (GO:0015893)3.95306832
28low-density lipoprotein particle clearance (GO:0034383)3.95046821
29amino-acid betaine metabolic process (GO:0006577)3.83467314
30carnitine shuttle (GO:0006853)3.80035712
31homocysteine metabolic process (GO:0050667)3.76300206
32branched-chain amino acid metabolic process (GO:0009081)3.75837359
33fatty acid catabolic process (GO:0009062)3.75135973
34aromatic amino acid family catabolic process (GO:0009074)3.75018781
35carnitine metabolic process (GO:0009437)3.69555122
36* response to mercury ion (GO:0046689)3.66687482
37kynurenine metabolic process (GO:0070189)3.66532809
38biotin metabolic process (GO:0006768)3.62894460
39alpha-linolenic acid metabolic process (GO:0036109)3.62329181
40phosphate ion transport (GO:0006817)3.60622284
41tricarboxylic acid cycle (GO:0006099)3.58578683
42drug catabolic process (GO:0042737)3.55470321
43phosphate ion transmembrane transport (GO:0035435)3.55209478
44cellular ketone body metabolic process (GO:0046950)3.53645839
45sulfur amino acid catabolic process (GO:0000098)3.53642957
46vascular endothelial growth factor signaling pathway (GO:0038084)3.53039738
47indole-containing compound catabolic process (GO:0042436)3.51903680
48indolalkylamine catabolic process (GO:0046218)3.51903680
49tryptophan catabolic process (GO:0006569)3.51903680
50ethanol oxidation (GO:0006069)3.46693127
51carnitine transmembrane transport (GO:1902603)3.46014451
52chemical homeostasis within a tissue (GO:0048875)3.44724276
53branched-chain amino acid catabolic process (GO:0009083)3.41354419
54NADH metabolic process (GO:0006734)3.38397510
55monocarboxylic acid catabolic process (GO:0072329)3.35999158
56oxaloacetate metabolic process (GO:0006107)3.33374976
57tryptophan metabolic process (GO:0006568)3.30219173
58exogenous drug catabolic process (GO:0042738)3.30190670
59retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28626581
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28324529
61organic cation transport (GO:0015695)3.27684520
62regulation of sequestering of triglyceride (GO:0010889)3.26625965
63cGMP-mediated signaling (GO:0019934)3.20900381
64serine family amino acid catabolic process (GO:0009071)3.16993761
65transcytosis (GO:0045056)3.15444550
66sodium ion export (GO:0071436)3.15412389
67regulation of cholesterol storage (GO:0010885)3.12317570
68regulation of fatty acid oxidation (GO:0046320)3.11390074
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.07047733
70astrocyte differentiation (GO:0048708)3.06766465
71positive regulation of fatty acid oxidation (GO:0046321)3.03637284
72cellular modified amino acid catabolic process (GO:0042219)3.01307578
73ketone body metabolic process (GO:1902224)3.00734695
74alpha-amino acid catabolic process (GO:1901606)2.98745023
75drug metabolic process (GO:0017144)2.97530481
76glutamate metabolic process (GO:0006536)2.94482008
77succinate metabolic process (GO:0006105)2.94282927
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92813004
79carboxylic acid catabolic process (GO:0046395)2.92115720
80organic acid catabolic process (GO:0016054)2.92115720
81lymph vessel development (GO:0001945)2.92068204
82cellular amino acid catabolic process (GO:0009063)2.91871075
83epoxygenase P450 pathway (GO:0019373)2.91595014
84regulation of endothelial cell differentiation (GO:0045601)2.91242833
85cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.90741573
86regulation of fatty acid beta-oxidation (GO:0031998)2.89536335
87blood vessel maturation (GO:0001955)2.89121222
88cellular response to epinephrine stimulus (GO:0071872)2.88912630
89negative regulation of fibrinolysis (GO:0051918)2.88892211
90response to phenylpropanoid (GO:0080184)2.87944907
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86428248
92axon ensheathment in central nervous system (GO:0032291)2.83944040
93central nervous system myelination (GO:0022010)2.83944040
94excretion (GO:0007588)2.83210824
95complement activation, alternative pathway (GO:0006957)2.83058002
96cellular potassium ion homeostasis (GO:0030007)2.82954474
97bile acid biosynthetic process (GO:0006699)2.82926136
98regulation of cholesterol homeostasis (GO:2000188)2.82174813
99plasma lipoprotein particle clearance (GO:0034381)2.80862149
100negative regulation of catenin import into nucleus (GO:0035414)2.80763570
101cellular sodium ion homeostasis (GO:0006883)2.78943952
102cell communication by electrical coupling (GO:0010644)2.76912678
103extracellular matrix assembly (GO:0085029)2.75078511
104regulation of triglyceride catabolic process (GO:0010896)2.74313442
105response to growth hormone (GO:0060416)2.73593768
106myelination in peripheral nervous system (GO:0022011)2.73480546
107peripheral nervous system axon ensheathment (GO:0032292)2.73480546
108aminoglycoside antibiotic metabolic process (GO:0030647)2.72621410
109regulation of p38MAPK cascade (GO:1900744)2.72259286
110serine family amino acid metabolic process (GO:0009069)2.70161617
111hormone catabolic process (GO:0042447)2.69457891
112barbed-end actin filament capping (GO:0051016)2.68378282
113regulation of protein activation cascade (GO:2000257)2.67747624
114regulation of complement activation (GO:0030449)2.65821436
115aromatic amino acid family metabolic process (GO:0009072)2.65759088
116endothelial cell morphogenesis (GO:0001886)2.65059509
117neuronal ion channel clustering (GO:0045161)2.64674537
118phospholipid homeostasis (GO:0055091)2.64457561
119myofibril assembly (GO:0030239)2.63315380
120extracellular fibril organization (GO:0043206)2.62931311
121cell migration involved in heart development (GO:0060973)2.62479775
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62148786
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.61720890
124cardiac myofibril assembly (GO:0055003)2.59943308
125positive regulation of receptor recycling (GO:0001921)2.57801084
126activation of protein kinase A activity (GO:0034199)2.55669909
127astrocyte development (GO:0014002)2.55217581
128virion attachment to host cell (GO:0019062)2.53639787
129adhesion of symbiont to host cell (GO:0044650)2.53639787
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.51802023
131regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.51769964
132response to epinephrine (GO:0071871)2.50483898
133cell communication involved in cardiac conduction (GO:0086065)2.50380090
134regulation of actin filament-based movement (GO:1903115)2.47295366
135regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46569222
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45469990
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44735573
138cardiac muscle contraction (GO:0060048)2.41657537
139cAMP biosynthetic process (GO:0006171)2.41245840
140regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40414510
141glomerular basement membrane development (GO:0032836)2.39550925
142endothelium development (GO:0003158)2.38876005
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37568661
144regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36952979
145fibril organization (GO:0097435)2.33993961
146sodium ion homeostasis (GO:0055078)2.31009123
147actin filament depolymerization (GO:0030042)2.29596344
148triglyceride catabolic process (GO:0019433)2.29211508
149cellular response to monoamine stimulus (GO:0071868)2.27503709
150cellular response to catecholamine stimulus (GO:0071870)2.27503709
151negative regulation of complement activation (GO:0045916)2.26443955
152regulation of integrin-mediated signaling pathway (GO:2001044)2.25228252
153striated muscle hypertrophy (GO:0014897)2.24457627
154* renal absorption (GO:0070293)2.24014936
155response to dietary excess (GO:0002021)2.22695542
156actin filament capping (GO:0051693)2.22365773
157atrioventricular valve morphogenesis (GO:0003181)2.21640046
158adhesion of symbiont to host (GO:0044406)2.21040206
159regulation of cardiac muscle cell contraction (GO:0086004)2.20257559
160potassium ion homeostasis (GO:0055075)2.17471706
161regulation of the force of heart contraction (GO:0002026)2.17254629
162complement activation, classical pathway (GO:0006958)2.15811891
163potassium ion import (GO:0010107)2.15418352
164creatine metabolic process (GO:0006600)2.15369100
165neuron projection regeneration (GO:0031102)2.14968309
166positive regulation of p38MAPK cascade (GO:1900745)2.14677956
167muscle filament sliding (GO:0030049)2.13732648
168actin-myosin filament sliding (GO:0033275)2.13732648
169endothelial cell chemotaxis (GO:0035767)2.13030973
170negative regulation of protein localization to cell surface (GO:2000009)2.11956382
171negative regulation of actin filament bundle assembly (GO:0032232)2.10462533
172neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.10063050
173* cell volume homeostasis (GO:0006884)2.09916043
174acylglycerol catabolic process (GO:0046464)2.09371824
175neutral lipid catabolic process (GO:0046461)2.09371824
176regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.08814416
177complement activation (GO:0006956)2.08336006
178muscle hypertrophy (GO:0014896)2.07762733
179myelin maintenance (GO:0043217)2.07125587
180import into cell (GO:0098657)2.06969704
181positive regulation of glucose import (GO:0046326)2.06545059
182response to monoamine (GO:0071867)2.06256016
183response to catecholamine (GO:0071869)2.06256016
184venous blood vessel morphogenesis (GO:0048845)2.06170948
185regulation of extracellular matrix disassembly (GO:0010715)2.05952003
186regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.05146900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.44091263
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.52393135
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.76267080
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.18818567
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.93037234
6* CLOCK_20551151_ChIP-Seq_293T_Human3.40826879
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.31403982
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.12945218
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00888772
10GATA1_22025678_ChIP-Seq_K562_Human2.92896495
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.87442095
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85538772
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68064920
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38202143
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28211825
16ZNF263_19887448_ChIP-Seq_K562_Human2.18959728
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.16602794
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.11944427
19EZH2_22144423_ChIP-Seq_EOC_Human2.04734206
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96557396
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.89728802
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88534570
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.85581768
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84438675
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.81729362
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.81729362
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81005575
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72952084
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71163608
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70314702
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70314702
32DROSHA_22980978_ChIP-Seq_HELA_Human1.70074577
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68070561
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66846658
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.66578091
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66147744
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64116333
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.62679729
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.60629291
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60079700
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58545981
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54103430
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52438926
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49093017
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47814306
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46375106
47* GATA1_19941826_ChIP-Seq_K562_Human1.45429517
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45342814
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44402511
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42637306
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.42511722
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.39849532
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39329052
54RACK7_27058665_Chip-Seq_MCF-7_Human1.38741280
55* LXR_22292898_ChIP-Seq_THP-1_Human1.37466066
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35309427
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.33601888
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32048566
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.31847492
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31603295
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30829301
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30716090
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.29158485
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27331357
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27011462
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25975978
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.24616366
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24391417
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22591727
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21723104
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.20997119
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20305018
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.19805132
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19398384
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19318269
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17836014
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17627142
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16460810
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13738278
80GATA4_25053715_ChIP-Seq_YYC3_Human1.13009991
81* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12261554
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.12169074
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10985473
84* GATA2_19941826_ChIP-Seq_K562_Human1.10208083
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09201677
86CJUN_26792858_Chip-Seq_BT549_Human1.08608317
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.08327440
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05746978
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05041415
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03864227
91ATF3_27146783_Chip-Seq_COLON_Human1.03767302
92SOX2_20726797_ChIP-Seq_SW620_Human1.03685691
93CTCF_27219007_Chip-Seq_Bcells_Human1.03596822
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01011771
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00655688
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99663300
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98877754
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98521852
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97500278
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.96667180
101* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96466049
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95655993
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93832560
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93209369
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92008360
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91026612
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90809332
108HNF4A_19822575_ChIP-Seq_HepG2_Human0.90149551
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88861195
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88313134
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87520788
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87299520
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86928509
114RARB_27405468_Chip-Seq_BRAIN_Mouse0.86628639
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.86562406
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86219238
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84350452
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83585694
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83475718
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83439869
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.82086279
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.80397711
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80353384
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80125235
125GATA6_25053715_ChIP-Seq_YYC3_Human0.80064729
126* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79985486
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.79882940
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79814134
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.79190904
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79060073
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78549323
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78414892
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78039223
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77627547
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.77492249
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77408089
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77049234
138* ISL1_27105846_Chip-Seq_CPCs_Mouse0.76618954
139ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76576513
140* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74999360
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74662623
142CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73994770
143KDM2B_26808549_Chip-Seq_DND41_Human0.73657280
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73587131
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72854401
146KDM2B_26808549_Chip-Seq_K562_Human0.72261336
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72185659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.16651520
2MP0002139_abnormal_hepatobiliary_system4.18962616
3MP0010368_abnormal_lymphatic_system3.14432220
4MP0005503_abnormal_tendon_morphology2.98796910
5MP0003690_abnormal_glial_cell2.86891048
6MP0002138_abnormal_hepatobiliary_system2.77793175
7MP0003724_increased_susceptibility_to2.77390687
8MP0008875_abnormal_xenobiotic_pharmacok2.68502534
9MP0005085_abnormal_gallbladder_physiolo2.61900514
10MP0005365_abnormal_bile_salt2.61411788
11MP0005332_abnormal_amino_acid2.52881969
12MP0003191_abnormal_cellular_cholesterol2.34934494
13MP0001958_emphysema2.33022378
14MP0000751_myopathy2.28824149
15MP0002837_dystrophic_cardiac_calcinosis2.21959285
16MP0009780_abnormal_chondrocyte_physiolo2.21292628
17MP0004272_abnormal_basement_membrane2.20984562
18MP0004043_abnormal_pH_regulation2.18016459
19MP0005167_abnormal_blood-brain_barrier2.17673150
20MP0001879_abnormal_lymphatic_vessel2.17196616
21MP0005670_abnormal_white_adipose2.16376500
22MP0003705_abnormal_hypodermis_morpholog2.15978312
23MP0003252_abnormal_bile_duct2.13341469
24MP0004130_abnormal_muscle_cell2.12975124
25MP0003195_calcinosis2.08846808
26* MP0009643_abnormal_urine_homeostasis2.03891509
27MP0004084_abnormal_cardiac_muscle2.03662267
28MP0004019_abnormal_vitamin_homeostasis1.99395189
29MP0008438_abnormal_cutaneous_collagen1.97949199
30MP0004147_increased_porphyrin_level1.96255447
31MP0010329_abnormal_lipoprotein_level1.96189916
32MP0003806_abnormal_nucleotide_metabolis1.85244591
33MP0005666_abnormal_adipose_tissue1.79495023
34* MP0001756_abnormal_urination1.76415221
35MP0003329_amyloid_beta_deposits1.58984087
36MP0003300_gastrointestinal_ulcer1.58982631
37MP0005409_darkened_coat_color1.58251880
38MP0004036_abnormal_muscle_relaxation1.57911751
39MP0005330_cardiomyopathy1.57485499
40MP0005319_abnormal_enzyme/_coenzyme1.51809333
41MP0003646_muscle_fatigue1.46936261
42MP0005275_abnormal_skin_tensile1.46373914
43MP0000749_muscle_degeneration1.42127225
44* MP0004215_abnormal_myocardial_fiber1.41502473
45MP0005636_abnormal_mineral_homeostasis1.41495133
46MP0001765_abnormal_ion_homeostasis1.40682002
47MP0003091_abnormal_cell_migration1.40006592
48MP0006054_spinal_hemorrhage1.39673533
49MP0002118_abnormal_lipid_homeostasis1.36878836
50MP0000750_abnormal_muscle_regeneration1.36504842
51MP0000920_abnormal_myelination1.34869359
52MP0008775_abnormal_heart_ventricle1.34550310
53MP0003075_altered_response_to1.34454465
54MP0002136_abnormal_kidney_physiology1.34314602
55MP0003566_abnormal_cell_adhesion1.33466490
56* MP0002133_abnormal_respiratory_system1.32672342
57* MP0005388_respiratory_system_phenotype1.32672342
58MP0000609_abnormal_liver_physiology1.32145695
59MP0004185_abnormal_adipocyte_glucose1.31921863
60MP0006138_congestive_heart_failure1.29692325
61MP0003656_abnormal_erythrocyte_physiolo1.29674292
62MP0003879_abnormal_hair_cell1.28998332
63MP0003828_pulmonary_edema1.28987428
64MP0004885_abnormal_endolymph1.28477107
65MP0005083_abnormal_biliary_tract1.25623419
66MP0006036_abnormal_mitochondrial_physio1.24481459
67MP0009115_abnormal_fat_cell1.22531554
68MP0000343_altered_response_to1.22217685
69MP0001502_abnormal_circadian_rhythm1.21944918
70MP0005385_cardiovascular_system_phenoty1.21282213
71MP0001544_abnormal_cardiovascular_syste1.21282213
72MP0005584_abnormal_enzyme/coenzyme_acti1.19439091
73MP0003186_abnormal_redox_activity1.18948282
74MP0004087_abnormal_muscle_fiber1.18870724
75MP0003950_abnormal_plasma_membrane1.18630048
76MP0005375_adipose_tissue_phenotype1.17800874
77MP0005023_abnormal_wound_healing1.15860917
78MP0003045_fibrosis1.14746633
79MP0008961_abnormal_basal_metabolism1.13248198
80MP0003279_aneurysm1.13108820
81MP0009840_abnormal_foam_cell1.12602717
82MP0001177_atelectasis1.11331757
83MP0001666_abnormal_nutrient_absorption1.09108132
84MP0005620_abnormal_muscle_contractility1.05769666
85MP0005377_hearing/vestibular/ear_phenot1.05632038
86MP0003878_abnormal_ear_physiology1.05632038
87MP0002972_abnormal_cardiac_muscle1.04606898
88MP0001501_abnormal_sleep_pattern1.04570029
89MP0000566_synostosis1.03841693
90MP0000230_abnormal_systemic_arterial1.00103283
91MP0005166_decreased_susceptibility_to0.99237696
92MP0000013_abnormal_adipose_tissue0.98533147
93MP0002971_abnormal_brown_adipose0.98104947
94MP0005165_increased_susceptibility_to0.97358933
95MP0005369_muscle_phenotype0.96518839
96MP0002933_joint_inflammation0.96478404
97MP0010630_abnormal_cardiac_muscle0.95896176
98MP0002332_abnormal_exercise_endurance0.94372535
99MP0003137_abnormal_impulse_conducting0.92835087
100MP0004859_abnormal_synaptic_plasticity0.92478374
101MP0004085_abnormal_heartbeat0.91105698
102MP0003634_abnormal_glial_cell0.90935880
103MP0004782_abnormal_surfactant_physiolog0.90268937
104MP0004484_altered_response_of0.89447158
105MP0005508_abnormal_skeleton_morphology0.88765351
106MP0000747_muscle_weakness0.87818516
107MP0002998_abnormal_bone_remodeling0.85640059
108MP0004270_analgesia0.85112728
109MP0000767_abnormal_smooth_muscle0.82396425
110MP0002269_muscular_atrophy0.81924921
111MP0002168_other_aberrant_phenotype0.80744513
112MP0009764_decreased_sensitivity_to0.80170015
113MP0005595_abnormal_vascular_smooth0.79389420
114MP0000604_amyloidosis0.79066628
115MP0005257_abnormal_intraocular_pressure0.78923901
116MP0000598_abnormal_liver_morphology0.77409395
117MP0002796_impaired_skin_barrier0.77237185
118MP0002295_abnormal_pulmonary_circulatio0.77161694
119MP0003633_abnormal_nervous_system0.76685751
120MP0002128_abnormal_blood_circulation0.75763081
121* MP0000249_abnormal_blood_vessel0.73740446
122MP0001542_abnormal_bone_strength0.72798084
123MP0001851_eye_inflammation0.72404076
124MP0001764_abnormal_homeostasis0.71740817
125MP0000462_abnormal_digestive_system0.71574860
126MP0002896_abnormal_bone_mineralization0.70465462
127MP0005164_abnormal_response_to0.70278719
128MP0002106_abnormal_muscle_physiology0.70242076
129MP0005535_abnormal_body_temperature0.68054352
130MP0009278_abnormal_bone_marrow0.67319722
131MP0000759_abnormal_skeletal_muscle0.66998972
132MP0000003_abnormal_adipose_tissue0.65633215
133MP0008004_abnormal_stomach_pH0.65386233
134MP0001661_extended_life_span0.65184917
135MP0002135_abnormal_kidney_morphology0.63859259
136MP0002108_abnormal_muscle_morphology0.61174880
137MP0001545_abnormal_hematopoietic_system0.61091259
138MP0005397_hematopoietic_system_phenotyp0.61091259

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)4.59804323
2Gout (HP:0001997)4.35893444
3Hypokalemic alkalosis (HP:0001949)4.35443498
4Hyperglycinuria (HP:0003108)4.12190014
5Interstitial pulmonary disease (HP:0006530)3.96778025
6Metabolic alkalosis (HP:0200114)3.87720105
7Polycythemia (HP:0001901)3.82870545
8Systemic lupus erythematosus (HP:0002725)3.75713400
9Abnormality of chloride homeostasis (HP:0011422)3.73062592
10Abnormality of fatty-acid metabolism (HP:0004359)3.69833845
11Ketoacidosis (HP:0001993)3.67360385
12Glomerulonephritis (HP:0000099)3.65874314
13Ketosis (HP:0001946)3.52291000
14Abnormality of glycine metabolism (HP:0010895)3.47742133
15Abnormality of serine family amino acid metabolism (HP:0010894)3.47742133
16Hyperuricemia (HP:0002149)3.47705036
17Increased purine levels (HP:0004368)3.47705036
18Abnormality of purine metabolism (HP:0004352)3.45837315
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.45041113
20Increased circulating renin level (HP:0000848)3.38504856
21Muscle fiber splitting (HP:0003555)3.34801938
22Abnormal urine output (HP:0012590)3.31194201
23Increased connective tissue (HP:0009025)3.31092369
24Deep venous thrombosis (HP:0002625)3.23659152
25Abnormality of complement system (HP:0005339)3.22165755
26Abnormality of renal excretion (HP:0011036)3.15225373
27Hyperammonemia (HP:0001987)3.13138359
28Polyuria (HP:0000103)3.12121821
29Renal salt wasting (HP:0000127)3.11412034
30Hypomagnesemia (HP:0002917)3.07561016
31Aortic aneurysm (HP:0004942)3.04208569
32Obstructive sleep apnea (HP:0002870)2.99687404
33Hyperaldosteronism (HP:0000859)2.97277371
34Abnormality of skeletal muscle fiber size (HP:0012084)2.92489181
35Myoglobinuria (HP:0002913)2.92105061
36Proximal tubulopathy (HP:0000114)2.91762905
37Alkalosis (HP:0001948)2.90093700
38Hypoglycemic coma (HP:0001325)2.88294645
39Xanthomatosis (HP:0000991)2.87432735
40Aplasia involving bones of the upper limbs (HP:0009823)2.77652103
41Aplasia of the phalanges of the hand (HP:0009802)2.77652103
42Aplasia involving bones of the extremities (HP:0009825)2.77652103
43Distal lower limb muscle weakness (HP:0009053)2.75063295
44Generalized aminoaciduria (HP:0002909)2.74654620
45Bundle branch block (HP:0011710)2.72195318
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70719853
47Dicarboxylic aciduria (HP:0003215)2.70719853
48Neurofibrillary tangles (HP:0002185)2.65024800
49Nephritis (HP:0000123)2.64924336
50Abnormality of magnesium homeostasis (HP:0004921)2.59772146
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59529082
52Delayed CNS myelination (HP:0002188)2.57253819
53Abnormality of renin-angiotensin system (HP:0000847)2.56769808
54Hyporeflexia of lower limbs (HP:0002600)2.56235871
55Esophageal varix (HP:0002040)2.55776064
56Intrahepatic cholestasis (HP:0001406)2.55110252
57Hyperglycinemia (HP:0002154)2.54888469
58Vascular tortuosity (HP:0004948)2.54740518
59Shallow orbits (HP:0000586)2.50855438
60Abnormality of nucleobase metabolism (HP:0010932)2.49746696
61Abnormal atrioventricular conduction (HP:0005150)2.44454980
62Spinal rigidity (HP:0003306)2.41130897
63Metabolic acidosis (HP:0001942)2.40590658
64Lymphangioma (HP:0100764)2.40506947
65Atrioventricular block (HP:0001678)2.39816930
66Abnormality of proline metabolism (HP:0010907)2.38842551
67Hydroxyprolinuria (HP:0003080)2.38842551
68Cardiovascular calcification (HP:0011915)2.36710473
69Cerebral hemorrhage (HP:0001342)2.36430969
70Foot dorsiflexor weakness (HP:0009027)2.35898313
71Heart block (HP:0012722)2.32391796
72Vascular calcification (HP:0004934)2.32333447
73Acanthosis nigricans (HP:0000956)2.32212367
74Asymmetric septal hypertrophy (HP:0001670)2.31725481
75Hematochezia (HP:0002573)2.31424984
76Chondrocalcinosis (HP:0000934)2.31370187
77Hypoalphalipoproteinemia (HP:0003233)2.31080216
78Arterial tortuosity (HP:0005116)2.31048676
79Rhabdomyolysis (HP:0003201)2.30600722
80Tetany (HP:0001281)2.29146393
81Broad metatarsal (HP:0001783)2.28152949
82Abnormal drinking behavior (HP:0030082)2.28002733
83Polydipsia (HP:0001959)2.28002733
84Abnormality of the foot musculature (HP:0001436)2.26231788
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25700553
86Neck muscle weakness (HP:0000467)2.25697976
87Atrial fibrillation (HP:0005110)2.25654298
88Difficulty running (HP:0009046)2.25203008
89Vomiting (HP:0002013)2.24111830
90Exercise-induced myalgia (HP:0003738)2.22940537
91Exercise-induced muscle cramps (HP:0003710)2.22687357
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21517673
93Visceral angiomatosis (HP:0100761)2.21477117
94Complement deficiency (HP:0004431)2.20049493
95Mildly elevated creatine phosphokinase (HP:0008180)2.19522931
96Centrally nucleated skeletal muscle fibers (HP:0003687)2.19186090
97Hypoplasia of the iris (HP:0007676)2.18692221
98Turricephaly (HP:0000262)2.17413997
99Cerebral aneurysm (HP:0004944)2.16876988
100Type 1 muscle fiber predominance (HP:0003803)2.16404542
101Sudden death (HP:0001699)2.14700299
102Joint hemorrhage (HP:0005261)2.13756221
103Ventricular tachycardia (HP:0004756)2.13392256
104Growth hormone excess (HP:0000845)2.12114309
105Action tremor (HP:0002345)2.11854771
106Protrusio acetabuli (HP:0003179)2.11763145
107Aortic dissection (HP:0002647)2.11721281
108Abnormality of Sharpey fibers (HP:0100685)2.11576542
109Right ventricular cardiomyopathy (HP:0011663)2.11346563
110Potter facies (HP:0002009)2.10828965
111Facial shape deformation (HP:0011334)2.10828965
112Adrenal overactivity (HP:0002717)2.10221732
113EMG: myopathic abnormalities (HP:0003458)2.10210222
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08776262
115Hypokalemia (HP:0002900)2.08709244
116Spontaneous hematomas (HP:0007420)2.08175318
117Hemorrhage of the eye (HP:0011885)2.07165198
118Cavernous hemangioma (HP:0001048)2.06856799
119Muscle fiber inclusion bodies (HP:0100299)2.04705497
120Hemangiomatosis (HP:0007461)2.03939765
121Primary atrial arrhythmia (HP:0001692)2.03428291
122Nephrolithiasis (HP:0000787)2.02904449
123Nausea (HP:0002018)2.02438371
124Increased variability in muscle fiber diameter (HP:0003557)2.02160028
125Polar cataract (HP:0010696)2.01443481
126Osteolytic defects of the hand bones (HP:0009699)2.01109210
127Osteolytic defects of the phalanges of the hand (HP:0009771)2.01109210
128Cerebral inclusion bodies (HP:0100314)2.00991388
129Distal lower limb amyotrophy (HP:0008944)1.99568768
130Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99035121
131Axonal loss (HP:0003447)1.98252834
132Oligomenorrhea (HP:0000876)1.97865893
133Abnormality of sulfur amino acid metabolism (HP:0004339)1.96245527
134Segmental peripheral demyelination/remyelination (HP:0003481)1.95533243
135Abnormality of the nasal mucosa (HP:0000433)1.95479536
136Ventricular arrhythmia (HP:0004308)1.95263704
137Hypercortisolism (HP:0001578)1.94224369
138Bronchomalacia (HP:0002780)1.93276700
139Abnormal cartilage morphology (HP:0002763)1.92238157
140Supraventricular arrhythmia (HP:0005115)1.91832020
141Supraventricular tachycardia (HP:0004755)1.91390435
142Abnormality of potassium homeostasis (HP:0011042)1.91084165
143Wormian bones (HP:0002645)1.90321947
144Round ear (HP:0100830)1.89673468
145Generalized muscle weakness (HP:0003324)1.89508453
146Aneurysm (HP:0002617)1.89066477
147Nemaline bodies (HP:0003798)1.89013977
148Neonatal death (HP:0003811)1.87804730
149Lipoatrophy (HP:0100578)1.87051895
150Hyperlipoproteinemia (HP:0010980)1.86959871
151Glycosuria (HP:0003076)1.86114574
152Abnormality of urine glucose concentration (HP:0011016)1.86114574
153Conjunctival hamartoma (HP:0100780)1.86089181
154Increased CSF protein (HP:0002922)1.85925493
155Malnutrition (HP:0004395)1.85250742
156Neonatal onset (HP:0003623)1.84430898
157Abnormality of the intrinsic pathway (HP:0010989)1.84275234
158Prolonged QT interval (HP:0001657)1.83907634
159Pulmonary artery stenosis (HP:0004415)1.83791364
160Rapidly progressive (HP:0003678)1.82852502
161Amyloidosis (HP:0011034)1.82852070
162Syncope (HP:0001279)1.82491905
163Alacrima (HP:0000522)1.79795151
164Hyperkalemia (HP:0002153)1.77535632
165Bladder diverticulum (HP:0000015)1.76748498
166Partial duplication of thumb phalanx (HP:0009944)1.74875991
167Striae distensae (HP:0001065)1.73151212
168Lower limb amyotrophy (HP:0007210)1.73027800
169Overgrowth (HP:0001548)1.72300393
170Myotonia (HP:0002486)1.72155866
171Abnormality of the calf musculature (HP:0001430)1.70265712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.50253132
2TRIB33.39750467
3WNK33.32286179
4TGFBR23.22555059
5BCKDK3.19812221
6KDR3.16650199
7TTN3.15526120
8WNK42.70037034
9RIPK12.69628818
10ERN12.39490679
11OXSR12.20263495
12PKN22.17107652
13PDK42.02754222
14PDK32.02754222
15PRPF4B1.89871047
16SIK11.83416199
17FGFR41.77885303
18MYLK1.75994647
19MAP2K31.69337385
20MAP3K31.67125199
21PDK21.65471360
22MARK11.63065005
23NTRK31.59081434
24TGFBR11.58090669
25EPHB11.54157889
26OBSCN1.41665422
27LRRK21.41258106
28PTK61.40192258
29LMTK21.33422996
30EPHB21.31103046
31PDGFRA1.25772460
32NTRK11.23816911
33NEK11.19530926
34TESK11.16611019
35PTK2B1.15317329
36UHMK11.14882463
37MARK21.13390715
38CAMK2B1.11686520
39CAMK1D1.10664000
40ROCK21.08883271
41MAP3K71.06520776
42MST1R1.05167326
43CDC42BPA1.04890704
44MAPK71.02874141
45PHKG10.98335210
46PHKG20.98335210
47FER0.96643163
48CAMK2G0.93419501
49DAPK20.93093903
50PRKAA20.92953944
51DMPK0.88076580
52JAK20.85175920
53PINK10.85106886
54NTRK20.83817993
55JAK10.82978434
56PAK40.80717852
57MAPKAPK30.80412224
58LATS10.79129346
59STK38L0.79064871
60NLK0.79009059
61KSR20.78848314
62PRKD10.78790149
63MAPK120.78165925
64PRKD30.75683084
65PKN10.74115232
66RPS6KA20.72136525
67MAPK150.72020952
68GSK3A0.72004394
69STK380.71365723
70CAMK10.70876779
71PTK20.70761385
72CAMK2D0.70610553
73MAP3K130.69545327
74PRKAA10.68456667
75GRK50.67088023
76STK390.67004945
77TYRO30.65722990
78DDR20.65705142
79CAMK1G0.65254062
80SGK10.64755665
81INSRR0.64029096
82NEK90.63182962
83PDPK10.62067928
84MET0.61499527
85FES0.61128348
86PRKCH0.59945145
87TRPM70.59845242
88CSK0.59253042
89MOS0.59105489
90MAP3K20.58688460
91MAPK100.58500898
92PRKG20.58472142
93NEK60.57873228
94SGK30.57827750
95TBK10.57429894
96TYK20.57168241
97MAPK110.56793640
98FLT30.56120888
99FGFR30.56025396
100ICK0.55853685
101PAK60.55424506
102HIPK20.55352238
103FGFR20.54126421
104PIK3CG0.53076493
105MAP3K100.52885346
106STK100.52666135
107SGK2230.52623218
108SGK4940.52623218
109PIK3CA0.52378309
110MAP3K110.52076835
111ERBB20.51797008
112RET0.51219147
113CDK50.51180783
114ILK0.50829388
115PRKG10.49669995
116GRK10.49381953
117MAP3K60.47570721
118ABL20.47139583
119MAP2K10.46309401
120WNK10.43649207
121PAK20.42272460
122CAMK40.41632340
123EEF2K0.39577342
124MTOR0.37151287
125PDGFRB0.36340842
126EPHA30.33598465
127BMX0.32614379
128STK30.32490711
129ROCK10.31733917
130MAPK40.31199631
131NME20.30749954
132SGK20.30534426
133PRKD20.30324296
134PRKACG0.30266538
135PAK30.29118600
136MAP3K10.29069566
137PDK10.27853603
138LATS20.27852730

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.32392750
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.29153163
3Fatty acid degradation_Homo sapiens_hsa000713.22004933
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.16901816
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.14062002
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84179181
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54851446
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49243337
9Fatty acid metabolism_Homo sapiens_hsa012122.47910325
10Tryptophan metabolism_Homo sapiens_hsa003802.45740769
11Butanoate metabolism_Homo sapiens_hsa006502.45631287
12PPAR signaling pathway_Homo sapiens_hsa033202.39149923
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.21064209
14Nitrogen metabolism_Homo sapiens_hsa009102.18115688
15Pyruvate metabolism_Homo sapiens_hsa006202.16495582
16Arginine biosynthesis_Homo sapiens_hsa002202.12666923
17Peroxisome_Homo sapiens_hsa041462.03321524
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96415857
19Carbon metabolism_Homo sapiens_hsa012001.87927326
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84860566
21beta-Alanine metabolism_Homo sapiens_hsa004101.82015370
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77891253
23Caffeine metabolism_Homo sapiens_hsa002321.76978503
24* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69170463
25* Bile secretion_Homo sapiens_hsa049761.57201669
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54469041
27Complement and coagulation cascades_Homo sapiens_hsa046101.47429583
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.42561499
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40751868
30* Renin secretion_Homo sapiens_hsa049241.33875628
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32415981
32Gastric acid secretion_Homo sapiens_hsa049711.30721476
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.29778573
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24397420
35Vitamin digestion and absorption_Homo sapiens_hsa049771.21686533
36Starch and sucrose metabolism_Homo sapiens_hsa005001.20053041
37Prion diseases_Homo sapiens_hsa050201.18805549
38Circadian rhythm_Homo sapiens_hsa047101.18045553
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16987471
40Selenocompound metabolism_Homo sapiens_hsa004501.16165279
41Fatty acid elongation_Homo sapiens_hsa000621.11662689
42Biosynthesis of amino acids_Homo sapiens_hsa012301.11303081
43Sulfur metabolism_Homo sapiens_hsa009201.10787795
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.09135531
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08678277
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08622869
47Lysine degradation_Homo sapiens_hsa003101.07494845
48Circadian entrainment_Homo sapiens_hsa047131.03884390
49Protein digestion and absorption_Homo sapiens_hsa049741.03291080
50Long-term potentiation_Homo sapiens_hsa047201.02512796
51Phenylalanine metabolism_Homo sapiens_hsa003601.01296489
52ECM-receptor interaction_Homo sapiens_hsa045121.01189888
53Chemical carcinogenesis_Homo sapiens_hsa052041.00844428
54GnRH signaling pathway_Homo sapiens_hsa049121.00677729
55Arginine and proline metabolism_Homo sapiens_hsa003300.99748220
56Fat digestion and absorption_Homo sapiens_hsa049750.97962578
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.97497030
58Insulin secretion_Homo sapiens_hsa049110.97007731
59Histidine metabolism_Homo sapiens_hsa003400.96374838
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96352499
61Salivary secretion_Homo sapiens_hsa049700.96030950
62Glycerolipid metabolism_Homo sapiens_hsa005610.95569598
63Fatty acid biosynthesis_Homo sapiens_hsa000610.94967534
64Pancreatic secretion_Homo sapiens_hsa049720.94961783
65ABC transporters_Homo sapiens_hsa020100.93139271
66Dorso-ventral axis formation_Homo sapiens_hsa043200.93114527
67Glutathione metabolism_Homo sapiens_hsa004800.88299149
68Staphylococcus aureus infection_Homo sapiens_hsa051500.85450364
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84915346
70cAMP signaling pathway_Homo sapiens_hsa040240.84363861
71Oxytocin signaling pathway_Homo sapiens_hsa049210.83897872
72Pertussis_Homo sapiens_hsa051330.83347386
73Insulin resistance_Homo sapiens_hsa049310.83127514
74Amphetamine addiction_Homo sapiens_hsa050310.81567749
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80723216
76Glutamatergic synapse_Homo sapiens_hsa047240.80153845
77Gap junction_Homo sapiens_hsa045400.78841887
78Ovarian steroidogenesis_Homo sapiens_hsa049130.77925128
79Cocaine addiction_Homo sapiens_hsa050300.77352775
80Notch signaling pathway_Homo sapiens_hsa043300.77036038
81Estrogen signaling pathway_Homo sapiens_hsa049150.74919726
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.74488132
83Retinol metabolism_Homo sapiens_hsa008300.74040356
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.73241647
85Rap1 signaling pathway_Homo sapiens_hsa040150.73198420
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72784819
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72731079
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69602321
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69101889
90Tyrosine metabolism_Homo sapiens_hsa003500.67990161
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66473038
92Choline metabolism in cancer_Homo sapiens_hsa052310.66227666
93Calcium signaling pathway_Homo sapiens_hsa040200.65253694
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.65160125
95Pentose phosphate pathway_Homo sapiens_hsa000300.64859498
96Folate biosynthesis_Homo sapiens_hsa007900.64698500
97Focal adhesion_Homo sapiens_hsa045100.64344968
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63353697
99Renal cell carcinoma_Homo sapiens_hsa052110.62606351
100GABAergic synapse_Homo sapiens_hsa047270.62403185
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59536354
102Morphine addiction_Homo sapiens_hsa050320.59097299
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58375859
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.57074782
105Glioma_Homo sapiens_hsa052140.56912116
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56273771
107Ras signaling pathway_Homo sapiens_hsa040140.55755064
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55399222
109Dilated cardiomyopathy_Homo sapiens_hsa054140.55075200
110VEGF signaling pathway_Homo sapiens_hsa043700.54216880
111Sulfur relay system_Homo sapiens_hsa041220.54060580
112AMPK signaling pathway_Homo sapiens_hsa041520.53796373
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53615528
114Melanogenesis_Homo sapiens_hsa049160.53340820
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52815311
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52679226
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51865009
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50900153
119Cholinergic synapse_Homo sapiens_hsa047250.49265782
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.49201337
121Malaria_Homo sapiens_hsa051440.48738150
122Proteoglycans in cancer_Homo sapiens_hsa052050.48301788
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48204111
124Inositol phosphate metabolism_Homo sapiens_hsa005620.48176906
125Arachidonic acid metabolism_Homo sapiens_hsa005900.47333889
126Renin-angiotensin system_Homo sapiens_hsa046140.45000002
127Cardiac muscle contraction_Homo sapiens_hsa042600.38978462
128Amoebiasis_Homo sapiens_hsa051460.37990811
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37867335
130Fructose and mannose metabolism_Homo sapiens_hsa000510.37653231
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36514836
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.35988355
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33441371
134Metabolic pathways_Homo sapiens_hsa011000.33330712
135Glucagon signaling pathway_Homo sapiens_hsa049220.32759470
136Insulin signaling pathway_Homo sapiens_hsa049100.32132059
137Parkinsons disease_Homo sapiens_hsa050120.29878728
138Small cell lung cancer_Homo sapiens_hsa052220.28194566
139Galactose metabolism_Homo sapiens_hsa000520.26831193
140Mineral absorption_Homo sapiens_hsa049780.25722946
141Oxidative phosphorylation_Homo sapiens_hsa001900.23206972
142Adherens junction_Homo sapiens_hsa045200.23142141
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20811412
144Thyroid hormone synthesis_Homo sapiens_hsa049180.20699464
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20356278
146Bladder cancer_Homo sapiens_hsa052190.16948578
147Tight junction_Homo sapiens_hsa045300.14259636
148Platelet activation_Homo sapiens_hsa046110.11890154
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10953264
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10806494
151Alzheimers disease_Homo sapiens_hsa050100.10763181

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