AQP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.89196474
2thrombin receptor signaling pathway (GO:0070493)7.45395379
3protein neddylation (GO:0045116)6.94277635
4blood coagulation, intrinsic pathway (GO:0007597)6.31051672
5regulation of platelet aggregation (GO:0090330)6.02135256
6negative regulation of thymocyte apoptotic process (GO:0070244)5.61683307
7regulation of platelet activation (GO:0010543)5.52104360
8platelet aggregation (GO:0070527)5.48404902
9adenosine receptor signaling pathway (GO:0001973)5.46529862
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.31423544
11leukocyte migration involved in inflammatory response (GO:0002523)5.28358299
12positive regulation of endothelial cell differentiation (GO:0045603)4.89477382
13negative regulation of norepinephrine secretion (GO:0010700)4.80393569
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.79689844
15neutrophil activation (GO:0042119)4.76726676
16positive regulation of mast cell activation (GO:0033005)4.75821752
17lipoxygenase pathway (GO:0019372)4.60112423
18negative regulation of platelet activation (GO:0010544)4.51335937
19regulation of integrin-mediated signaling pathway (GO:2001044)4.47633983
20angiogenesis involved in wound healing (GO:0060055)4.43398601
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.38315165
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.34609228
23negative regulation of heart rate (GO:0010459)4.31790568
24low-density lipoprotein particle remodeling (GO:0034374)4.17998282
25granulocyte activation (GO:0036230)4.17502821
26platelet degranulation (GO:0002576)4.14102680
27purinergic nucleotide receptor signaling pathway (GO:0035590)4.01910181
28megakaryocyte development (GO:0035855)4.01645918
29polyamine biosynthetic process (GO:0006596)3.96679669
30platelet formation (GO:0030220)3.91833304
31positive regulation of Rho protein signal transduction (GO:0035025)3.91390501
32regulation of lipoprotein metabolic process (GO:0050746)3.88696829
33homotypic cell-cell adhesion (GO:0034109)3.87568096
34platelet activation (GO:0030168)3.80723788
35regulation of Golgi to plasma membrane protein transport (GO:0042996)3.80719753
36regulation of integrin activation (GO:0033623)3.80242896
37positive regulation of macrophage differentiation (GO:0045651)3.77438536
38positive regulation of cAMP-mediated signaling (GO:0043950)3.75881392
39negative regulation of erythrocyte differentiation (GO:0045647)3.60872861
40fusion of sperm to egg plasma membrane (GO:0007342)3.57747280
41negative regulation of T cell apoptotic process (GO:0070233)3.55845128
42regulation of homotypic cell-cell adhesion (GO:0034110)3.53531903
43positive regulation of receptor recycling (GO:0001921)3.53327405
44autophagic vacuole fusion (GO:0000046)3.52255813
45purinergic receptor signaling pathway (GO:0035587)3.50435294
46G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.45134755
47negative regulation of protein localization to cell surface (GO:2000009)3.43093865
48leukocyte degranulation (GO:0043299)3.42746085
49positive regulation of hemostasis (GO:1900048)3.39999576
50positive regulation of blood coagulation (GO:0030194)3.39999576
51negative regulation of response to food (GO:0032096)3.38915268
52negative regulation of appetite (GO:0032099)3.38915268
53beta-amyloid metabolic process (GO:0050435)3.38614580
54regulation of MHC class II biosynthetic process (GO:0045346)3.36093344
55positive regulation of systemic arterial blood pressure (GO:0003084)3.34658306
56positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.33465627
57negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.31895492
58regulation of mast cell degranulation (GO:0043304)3.31040369
59high-density lipoprotein particle remodeling (GO:0034375)3.30348595
60mitochondrial calcium ion transport (GO:0006851)3.28264615
61termination of G-protein coupled receptor signaling pathway (GO:0038032)3.28208990
62termination of signal transduction (GO:0023021)3.27460943
63regulation of mast cell activation (GO:0033003)3.26783579
64regulation of macrophage derived foam cell differentiation (GO:0010743)3.25190044
65vesicle targeting (GO:0006903)3.24650309
66regulation of norepinephrine secretion (GO:0014061)3.23153544
67negative regulation of heart contraction (GO:0045822)3.19964326
68regulation of endothelial cell differentiation (GO:0045601)3.18947033
69negative regulation of neural precursor cell proliferation (GO:2000178)3.18304467
70positive regulation of granulocyte differentiation (GO:0030854)3.16624308
71regulation of mast cell activation involved in immune response (GO:0033006)3.16468159
72Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16232032
73phospholipid homeostasis (GO:0055091)3.14229864
74negative regulation of stress fiber assembly (GO:0051497)3.10990667
75reverse cholesterol transport (GO:0043691)3.07353433
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.05119229
77positive regulation of mast cell degranulation (GO:0043306)3.05119229
78pyrimidine nucleoside catabolic process (GO:0046135)3.04418369
79extracellular fibril organization (GO:0043206)3.03433328
80positive regulation of coagulation (GO:0050820)3.03252987
81regulation of cholesterol efflux (GO:0010874)3.03110243
82phagocytosis, engulfment (GO:0006911)2.93291905
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.92527652
84negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.91005899
85negative regulation of catecholamine secretion (GO:0033604)2.89615141
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89550064
87regulation of thymocyte apoptotic process (GO:0070243)2.88270667
88cyclooxygenase pathway (GO:0019371)2.87868351
89negative regulation of T-helper cell differentiation (GO:0045623)2.87358598
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87358598
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86557530
92long-chain fatty acid biosynthetic process (GO:0042759)2.86346346
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85036738
94positive regulation of cellular amide metabolic process (GO:0034250)2.84417331
95regulation of receptor recycling (GO:0001919)2.82752126
96regulation of hemostasis (GO:1900046)2.79246889
97regulation of blood coagulation (GO:0030193)2.79246889
98negative regulation of protein localization to plasma membrane (GO:1903077)2.77731751
99cellular biogenic amine biosynthetic process (GO:0042401)2.74729481
100negative regulation of cell junction assembly (GO:1901889)2.74697055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.00050774
2SCL_19346495_ChIP-Seq_HPC-7_Human4.85566782
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.47543002
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85531494
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.72933353
6GATA1_19941826_ChIP-Seq_K562_Human3.63515872
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.28950453
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse3.12031656
9* GATA2_19941826_ChIP-Seq_K562_Human2.96279867
10GATA1_19941827_ChIP-Seq_MEL_Mouse2.94279940
11SPI1_23127762_ChIP-Seq_K562_Human2.88782380
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.74447203
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71853618
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.70107655
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69244164
16TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.63396981
17GATA1_22383799_ChIP-Seq_G1ME_Mouse2.59715807
18GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.51690575
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40023788
20MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.34278455
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32683587
22RUNX1_22412390_ChIP-Seq_EML_Mouse2.31178423
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.30962439
24GATA1_22025678_ChIP-Seq_K562_Human2.14430104
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10075964
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.95478141
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.94977647
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89882740
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88882504
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87614537
31GATA1_19941827_ChIP-Seq_MEL86_Mouse1.68313342
32GATA2_22383799_ChIP-Seq_G1ME_Mouse1.66714973
33* NCOR1_26117541_ChIP-Seq_K562_Human1.65474822
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63693256
35HTT_18923047_ChIP-ChIP_STHdh_Human1.58284517
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53655232
37RUNX_20019798_ChIP-Seq_JUKART_Human1.49842721
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48153087
39EZH2_22144423_ChIP-Seq_EOC_Human1.47463122
40SPI1_23547873_ChIP-Seq_NB4_Human1.45759886
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42465051
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40704024
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39967345
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39895325
45UTX_26944678_Chip-Seq_JUKART_Human1.37382619
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35998534
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34527945
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34380595
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34042244
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32955783
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28220013
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27523718
53KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25065266
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23164059
55* SPI1_20517297_ChIP-Seq_HL60_Human1.20934502
56ETS1_22383799_ChIP-Seq_G1ME_Mouse1.18444209
57GBX2_23144817_ChIP-Seq_PC3_Human1.16181215
58VDR_24763502_ChIP-Seq_THP-1_Human1.09663877
59MYB_26560356_Chip-Seq_TH2_Human1.06221021
60GATA3_27048872_Chip-Seq_THYMUS_Human1.05556356
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05400592
62SALL4_22934838_ChIP-ChIP_CD34+_Human1.04909436
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00992096
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00071730
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99475219
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95340398
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94985028
68STAT1_20625510_ChIP-Seq_HELA_Human0.94003646
69HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93120346
70MAF_26560356_Chip-Seq_TH1_Human0.92751311
71TCF7_22412390_ChIP-Seq_EML_Mouse0.91242358
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90078759
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89766858
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89632772
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88893814
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88893814
77MYB_26560356_Chip-Seq_TH1_Human0.88285525
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88022095
79CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87772401
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85833138
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85817663
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84542080
83GATA3_26560356_Chip-Seq_TH2_Human0.84378444
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83667011
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79859590
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.78569051
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77996461
88TAF15_26573619_Chip-Seq_HEK293_Human0.76298007
89CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76107757
90* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75665437
91LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75368435
92RXR_22158963_ChIP-Seq_LIVER_Mouse0.75243354
93PU_27001747_Chip-Seq_BMDM_Mouse0.74975022
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.74954813
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74228824
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.74087273
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.73857575
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.73088317
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71581811
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71348883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.90215670
2MP0008004_abnormal_stomach_pH5.30579340
3MP0003724_increased_susceptibility_to3.86805122
4MP0000465_gastrointestinal_hemorrhage3.62715569
5MP0004510_myositis2.91366914
6MP0005083_abnormal_biliary_tract2.63332973
7MP0003303_peritoneal_inflammation2.44518710
8MP0001835_abnormal_antigen_presentation2.29112735
9MP0003566_abnormal_cell_adhesion2.21117316
10MP0000343_altered_response_to2.14133982
11MP0005058_abnormal_lysosome_morphology1.97347397
12MP0004084_abnormal_cardiac_muscle1.88638513
13MP0000230_abnormal_systemic_arterial1.80466936
14MP0002132_abnormal_respiratory_system1.79083694
15MP0003638_abnormal_response/metabolism_1.77824258
16MP0010155_abnormal_intestine_physiology1.76543221
17MP0002736_abnormal_nociception_after1.74687232
18MP0001851_eye_inflammation1.74294585
19MP0005671_abnormal_response_to1.73489039
20MP0003436_decreased_susceptibility_to1.71359299
21MP0003828_pulmonary_edema1.69454700
22MP0002398_abnormal_bone_marrow1.68217120
23MP0003879_abnormal_hair_cell1.66842244
24MP0002148_abnormal_hypersensitivity_rea1.66686934
25MP0005000_abnormal_immune_tolerance1.66510848
26MP0005397_hematopoietic_system_phenotyp1.66211181
27MP0001545_abnormal_hematopoietic_system1.66211181
28MP0008775_abnormal_heart_ventricle1.63295379
29MP0004947_skin_inflammation1.51935666
30MP0005084_abnormal_gallbladder_morpholo1.51828694
31MP0005410_abnormal_fertilization1.51804081
32MP0008872_abnormal_physiological_respon1.46826393
33MP0003300_gastrointestinal_ulcer1.45261977
34MP0004036_abnormal_muscle_relaxation1.42758554
35MP0003656_abnormal_erythrocyte_physiolo1.41310134
36MP0005167_abnormal_blood-brain_barrier1.40283493
37MP0002723_abnormal_immune_serum1.37541809
38MP0003866_abnormal_defecation1.31363518
39MP0001663_abnormal_digestive_system1.31271575
40MP0001800_abnormal_humoral_immune1.27998713
41MP0001879_abnormal_lymphatic_vessel1.27939468
42MP0000858_altered_metastatic_potential1.27798200
43MP0000249_abnormal_blood_vessel1.22943035
44MP0009763_increased_sensitivity_to1.22491086
45MP0002419_abnormal_innate_immunity1.22204662
46MP0000689_abnormal_spleen_morphology1.21867926
47MP0004130_abnormal_muscle_cell1.21724979
48MP0002429_abnormal_blood_cell1.21682222
49MP0009764_decreased_sensitivity_to1.21370566
50MP0002452_abnormal_antigen_presenting1.20532600
51MP0002722_abnormal_immune_system1.19860561
52MP0001533_abnormal_skeleton_physiology1.19270124
53MP0002420_abnormal_adaptive_immunity1.17820809
54MP0010329_abnormal_lipoprotein_level1.17421515
55MP0001819_abnormal_immune_cell1.16313548
56MP0001968_abnormal_touch/_nociception1.13011748
57MP0005387_immune_system_phenotype1.11339050
58MP0001790_abnormal_immune_system1.11339050
59MP0002733_abnormal_thermal_nociception1.11052344
60MP0000685_abnormal_immune_system1.10734756
61MP0005025_abnormal_response_to1.08548542
62MP0000716_abnormal_immune_system1.05357735
63MP0001845_abnormal_inflammatory_respons1.01956083
64MP0009697_abnormal_copulation1.01317173
65MP0005646_abnormal_pituitary_gland1.00481595
66MP0009642_abnormal_blood_homeostasis0.98713507
67MP0008874_decreased_physiological_sensi0.96627479
68MP0009765_abnormal_xenobiotic_induced0.92623015
69MP0000490_abnormal_crypts_of0.88080415
70MP0009333_abnormal_splenocyte_physiolog0.86179803
71MP0000703_abnormal_thymus_morphology0.84833135
72MP0006036_abnormal_mitochondrial_physio0.83124251
73MP0005381_digestive/alimentary_phenotyp0.81680727
74MP0004883_abnormal_blood_vessel0.81107461
75MP0009278_abnormal_bone_marrow0.80744063
76MP0008260_abnormal_autophagy0.79580304
77MP0002998_abnormal_bone_remodeling0.79165391
78MP0000015_abnormal_ear_pigmentation0.78720789
79MP0003075_altered_response_to0.78036065
80MP0005165_increased_susceptibility_to0.78003376
81MP0001765_abnormal_ion_homeostasis0.77244181
82MP0001970_abnormal_pain_threshold0.75603757
83MP0005385_cardiovascular_system_phenoty0.75338556
84MP0001544_abnormal_cardiovascular_syste0.75338556
85MP0002735_abnormal_chemical_nociception0.74473579
86MP0004215_abnormal_myocardial_fiber0.72985113
87MP0006035_abnormal_mitochondrial_morpho0.72186468
88MP0005535_abnormal_body_temperature0.71688105
89MP0005023_abnormal_wound_healing0.71681165
90MP0000358_abnormal_cell_content/0.71220425
91MP0005666_abnormal_adipose_tissue0.70870386
92MP0002972_abnormal_cardiac_muscle0.67590440
93MP0002118_abnormal_lipid_homeostasis0.67013046
94MP0004484_altered_response_of0.66142089
95MP0003453_abnormal_keratinocyte_physiol0.65091786
96MP0002405_respiratory_system_inflammati0.64958865
97MP0001664_abnormal_digestion0.64906745
98MP0002128_abnormal_blood_circulation0.64007128
99MP0005501_abnormal_skin_physiology0.63393503
100MP0009785_altered_susceptibility_to0.61007485

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.72116355
2Purpura (HP:0000979)9.25799101
3Epistaxis (HP:0000421)7.83340184
4Gingival bleeding (HP:0000225)6.50989180
5Hyperlipoproteinemia (HP:0010980)5.83132132
6Impaired platelet aggregation (HP:0003540)5.56828679
7Abnormal platelet function (HP:0011869)5.56828679
8Acanthocytosis (HP:0001927)4.35673276
9Spontaneous hematomas (HP:0007420)4.34019417
10Poikilocytosis (HP:0004447)4.28092670
11Dyschromatopsia (HP:0007641)3.86193318
12Abnormality of the common coagulation pathway (HP:0010990)3.59683502
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.57734878
14Conjunctival telangiectasia (HP:0000524)3.39965949
15Bruising susceptibility (HP:0000978)3.29515214
16Abnormal pupillary function (HP:0007686)3.24371349
17Abnormality of lateral ventricle (HP:0030047)3.22482718
18Abnormality of macrophages (HP:0004311)3.08655678
19Abnormality of the vasculature of the conjunctiva (HP:0008054)2.97469600
20Increased density of long bones (HP:0006392)2.86030681
21Paralysis (HP:0003470)2.80551995
22Hyperthyroidism (HP:0000836)2.73828706
23Chronic obstructive pulmonary disease (HP:0006510)2.65971277
24Obstructive lung disease (HP:0006536)2.65971277
25Hepatosplenomegaly (HP:0001433)2.57246103
26Polycythemia (HP:0001901)2.55084515
27Xanthomatosis (HP:0000991)2.53912023
28Stomatitis (HP:0010280)2.50916551
29Increased IgM level (HP:0003496)2.47595850
30Ventricular fibrillation (HP:0001663)2.38957599
31Joint swelling (HP:0001386)2.33698793
32Joint hemorrhage (HP:0005261)2.31264956
33Abnormality of iron homeostasis (HP:0011031)2.27814665
34Upper limb muscle weakness (HP:0003484)2.27115349
35Encephalitis (HP:0002383)2.26352439
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26017781
37Eczematoid dermatitis (HP:0000976)2.15832463
38Generalized aminoaciduria (HP:0002909)2.12435493
39Tinnitus (HP:0000360)2.11688364
40Nausea (HP:0002018)2.11179285
41Male infertility (HP:0003251)2.10999468
42Episodic fever (HP:0001954)2.09222466
43Decreased central vision (HP:0007663)2.08670933
44Abnormal auditory evoked potentials (HP:0006958)2.08446411
45Spontaneous abortion (HP:0005268)2.04285674
46Prolonged bleeding time (HP:0003010)12.0036430
47Menorrhagia (HP:0000132)11.0121463
48Increased mean platelet volume (HP:0011877)10.8218891
49Abnormal platelet volume (HP:0011876)10.3220378
50Abnormality of transition element cation homeostasis (HP:0011030)1.98535645
51Dysautonomia (HP:0002459)1.98192718
52Increased serum ferritin (HP:0003281)1.98038558
53Autoimmune hemolytic anemia (HP:0001890)1.87527621
54Arterial thrombosis (HP:0004420)1.84205671
553-Methylglutaconic aciduria (HP:0003535)1.81506592
56Papillary thyroid carcinoma (HP:0002895)1.73847378
57Myocardial infarction (HP:0001658)1.70761195
58Truncus arteriosus (HP:0001660)1.70442719
59Distal lower limb amyotrophy (HP:0008944)1.69128911
60Recurrent abscess formation (HP:0002722)1.68034761
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62965067
62Diplopia (HP:0000651)1.59543501
63Abnormality of binocular vision (HP:0011514)1.59543501
64Abnormal hemoglobin (HP:0011902)1.58980533
65Recurrent bacterial skin infections (HP:0005406)1.58732402
66Cholecystitis (HP:0001082)1.57988192
67Abnormal gallbladder physiology (HP:0012438)1.57988192
68Granulocytopenia (HP:0001913)1.56364625
69Inflammation of the large intestine (HP:0002037)1.54345151
70Abnormal ciliary motility (HP:0012262)1.54049206
71Vertigo (HP:0002321)1.52906087
72Thrombophlebitis (HP:0004418)1.50807234
73Abnormality of the prostate (HP:0008775)1.46037548
74Chest pain (HP:0100749)1.45339431
75Muscle fibrillation (HP:0010546)1.42872010
76Testicular neoplasm (HP:0010788)1.42247193
77Leukocytosis (HP:0001974)1.41896385
78Gastrointestinal inflammation (HP:0004386)1.41385857
79Hypertriglyceridemia (HP:0002155)1.40415500
80Hypochromic microcytic anemia (HP:0004840)1.39747946
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.39221996
82Abnormality of alanine metabolism (HP:0010916)1.39221996
83Hyperalaninemia (HP:0003348)1.39221996
84Thyroid-stimulating hormone excess (HP:0002925)1.38689487
85Abnormal large intestine physiology (HP:0012700)1.38532387
86Microcytic anemia (HP:0001935)1.37591321
87Hypophosphatemic rickets (HP:0004912)1.37446250
88Ileus (HP:0002595)1.37254866
89Tongue fasciculations (HP:0001308)1.36803089
90Arthropathy (HP:0003040)1.36153881
91Dysostosis multiplex (HP:0000943)1.34570877
92Leiomyosarcoma (HP:0100243)1.34277532
93Uterine leiomyosarcoma (HP:0002891)1.34277532
94Biliary tract neoplasm (HP:0100574)1.33971520
95Thrombocytosis (HP:0001894)1.33755775
96Chronic otitis media (HP:0000389)1.31158250
97Mucosal telangiectasiae (HP:0100579)1.31011250
98Basal ganglia calcification (HP:0002135)1.30881444
99Cerebral ischemia (HP:0002637)1.30859532
100Hemorrhage of the eye (HP:0011885)1.30269676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.54718192
2MST44.55051281
3BMX4.33420224
4EIF2AK13.94273938
5MYLK3.45642803
6TEC3.00984703
7BTK2.99329657
8PTK2B2.51021987
9SYK2.29727460
10BMPR22.20025585
11GRK62.14203125
12ZAP702.06189652
13CSF1R1.93692238
14ILK1.87292816
15GRK51.86794528
16FGR1.78441650
17PIK3CG1.75790910
18TAOK31.71471637
19BLK1.69499885
20MAP2K31.62501629
21HCK1.56818355
22STK31.45558542
23TNK21.37446194
24STK241.36210279
25FES1.32681728
26ADRBK21.31014584
27MAPKAPK31.24943986
28PAK11.21498927
29LYN1.20730091
30MATK1.20304955
31TAOK21.11252266
32IKBKB1.02334353
33DAPK31.01326778
34CSK0.99287696
35TAOK10.98337726
36SIK30.97666189
37PIM20.95333727
38MAP3K50.95142431
39RET0.89961188
40LMTK20.88410627
41MARK30.88049756
42TESK20.86906731
43ITK0.86294289
44PDK10.82560458
45IRAK10.82285358
46TNIK0.81318550
47ACVR1B0.80566906
48MAP3K30.80289311
49EPHA30.78355796
50PLK20.78174175
51MAP4K10.77709113
52MAP3K110.76787923
53DAPK20.72912884
54MAPK120.72676081
55PDPK10.72554668
56JAK20.68590336
57ADRBK10.68532285
58TXK0.68456209
59JAK30.66170682
60ERBB20.62485520
61PRKD10.61433602
62ARAF0.61048731
63PNCK0.60498406
64MAP3K10.56858424
65YES10.55638531
66EPHB10.55464534
67MAP2K10.55090925
68IRAK40.54644319
69PRKACG0.53027221
70LCK0.52337243
71RAF10.51898167
72PKN10.51897365
73KSR20.50896591
74FYN0.45911178
75TLK10.44277055
76FER0.44037639
77GRK10.42960858
78STK40.42933639
79MAP3K20.40426716
80PDGFRB0.40353297
81DAPK10.37153628
82PKN20.36506005
83CDK80.36117682
84MAPK130.34831759
85PIM10.32916354
86EPHB20.32783984
87MINK10.30954064
88PRKCD0.30527263
89PRKG10.30336632
90PRKCB0.30177088
91DYRK1B0.29501570
92JAK10.29475019
93TRIM280.29412055
94IRAK30.28790072
95DYRK30.26892959
96IRAK20.26606170
97MAPK110.26574137
98PRKCQ0.24679058
99SRC0.21758249
100CDK140.20806802

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.82757507
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.63824939
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.05191037
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.90606495
5Hematopoietic cell lineage_Homo sapiens_hsa046402.64847733
6ECM-receptor interaction_Homo sapiens_hsa045122.27093320
7Arachidonic acid metabolism_Homo sapiens_hsa005902.06470177
8Chemokine signaling pathway_Homo sapiens_hsa040622.02514390
9Gap junction_Homo sapiens_hsa045401.78416470
10Nitrogen metabolism_Homo sapiens_hsa009101.67222176
11B cell receptor signaling pathway_Homo sapiens_hsa046621.61018427
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.59412248
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57789871
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56496984
15Serotonergic synapse_Homo sapiens_hsa047261.51119846
16Shigellosis_Homo sapiens_hsa051311.49140629
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44377594
18Endocytosis_Homo sapiens_hsa041441.41973473
19Collecting duct acid secretion_Homo sapiens_hsa049661.36718306
20Alcoholism_Homo sapiens_hsa050341.27743166
21Osteoclast differentiation_Homo sapiens_hsa043801.27309510
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.22541642
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20215760
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16021864
25T cell receptor signaling pathway_Homo sapiens_hsa046601.15503542
26Systemic lupus erythematosus_Homo sapiens_hsa053221.12998172
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.12741224
28Malaria_Homo sapiens_hsa051441.11074740
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10641728
30Primary immunodeficiency_Homo sapiens_hsa053401.10020031
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08247252
32Glycerolipid metabolism_Homo sapiens_hsa005611.06877537
33Pancreatic secretion_Homo sapiens_hsa049721.05501033
34Pancreatic cancer_Homo sapiens_hsa052121.01754541
35Phagosome_Homo sapiens_hsa041451.00211891
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99818621
37Mismatch repair_Homo sapiens_hsa034300.97634014
38Olfactory transduction_Homo sapiens_hsa047400.92036303
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91249193
40Glutathione metabolism_Homo sapiens_hsa004800.89354036
41Fatty acid elongation_Homo sapiens_hsa000620.88065145
42Rap1 signaling pathway_Homo sapiens_hsa040150.85259621
43Sulfur metabolism_Homo sapiens_hsa009200.85108641
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84993559
45Long-term depression_Homo sapiens_hsa047300.84925490
46Staphylococcus aureus infection_Homo sapiens_hsa051500.84759994
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83625305
48Non-small cell lung cancer_Homo sapiens_hsa052230.82889889
49Linoleic acid metabolism_Homo sapiens_hsa005910.82243508
50Choline metabolism in cancer_Homo sapiens_hsa052310.78834991
51Focal adhesion_Homo sapiens_hsa045100.77123907
52Fat digestion and absorption_Homo sapiens_hsa049750.75171547
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74479218
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73309815
55Leishmaniasis_Homo sapiens_hsa051400.71106419
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.70267996
57Viral carcinogenesis_Homo sapiens_hsa052030.67482656
58Morphine addiction_Homo sapiens_hsa050320.66878296
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63322137
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62487840
61Endometrial cancer_Homo sapiens_hsa052130.61812235
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59487291
63Circadian entrainment_Homo sapiens_hsa047130.59038705
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58002861
65Renin-angiotensin system_Homo sapiens_hsa046140.56535991
66Starch and sucrose metabolism_Homo sapiens_hsa005000.56408427
67VEGF signaling pathway_Homo sapiens_hsa043700.55595759
68Ras signaling pathway_Homo sapiens_hsa040140.55058021
69Salmonella infection_Homo sapiens_hsa051320.53214831
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52797835
71Apoptosis_Homo sapiens_hsa042100.52701887
72Acute myeloid leukemia_Homo sapiens_hsa052210.51589391
73Chronic myeloid leukemia_Homo sapiens_hsa052200.51516636
74Tuberculosis_Homo sapiens_hsa051520.49175787
75Calcium signaling pathway_Homo sapiens_hsa040200.49065665
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48916602
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48752478
78Thyroid cancer_Homo sapiens_hsa052160.48470571
79Small cell lung cancer_Homo sapiens_hsa052220.47637374
80Amoebiasis_Homo sapiens_hsa051460.47184126
81Renal cell carcinoma_Homo sapiens_hsa052110.46857326
82Glioma_Homo sapiens_hsa052140.45827199
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44885844
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44674537
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43365901
86Legionellosis_Homo sapiens_hsa051340.42651453
87Pentose phosphate pathway_Homo sapiens_hsa000300.42623465
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41220725
89Dilated cardiomyopathy_Homo sapiens_hsa054140.40750276
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.39221641
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38784082
92Graft-versus-host disease_Homo sapiens_hsa053320.37422165
93Toxoplasmosis_Homo sapiens_hsa051450.37203222
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.36844640
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.36728778
96GABAergic synapse_Homo sapiens_hsa047270.36371978
97Galactose metabolism_Homo sapiens_hsa000520.34451431
98Complement and coagulation cascades_Homo sapiens_hsa046100.34011087
99Melanoma_Homo sapiens_hsa052180.32485419
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32110584

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