AQP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.84688135
2acrosome reaction (GO:0007340)6.90498576
3fusion of sperm to egg plasma membrane (GO:0007342)6.15543150
4axonemal dynein complex assembly (GO:0070286)5.92222442
5cilium or flagellum-dependent cell motility (GO:0001539)5.78748324
6motile cilium assembly (GO:0044458)5.62151509
7cell wall macromolecule metabolic process (GO:0044036)5.62061368
8cell wall macromolecule catabolic process (GO:0016998)5.62061368
9epithelial cilium movement (GO:0003351)5.59639957
10sperm-egg recognition (GO:0035036)5.52279286
11multicellular organism reproduction (GO:0032504)5.51775034
12coenzyme catabolic process (GO:0009109)5.29875552
13spermatid development (GO:0007286)5.24824099
14L-phenylalanine catabolic process (GO:0006559)5.14042695
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14042695
16organic cation transport (GO:0015695)5.09767025
17acrosome assembly (GO:0001675)5.04340958
18aromatic amino acid family catabolic process (GO:0009074)5.01078857
19binding of sperm to zona pellucida (GO:0007339)4.89309163
20tryptophan catabolic process (GO:0006569)4.88231722
21indole-containing compound catabolic process (GO:0042436)4.88231722
22indolalkylamine catabolic process (GO:0046218)4.88231722
23cell-cell recognition (GO:0009988)4.87249025
24epoxygenase P450 pathway (GO:0019373)4.76802406
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.67222057
26L-phenylalanine metabolic process (GO:0006558)4.67222057
27regulation of cilium movement (GO:0003352)4.64892679
28piRNA metabolic process (GO:0034587)4.63436354
29cilium movement (GO:0003341)4.59360532
30tryptophan metabolic process (GO:0006568)4.58221141
31plasma membrane fusion (GO:0045026)4.57619466
32reproduction (GO:0000003)4.56949729
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.54424638
34high-density lipoprotein particle remodeling (GO:0034375)4.21092395
35kynurenine metabolic process (GO:0070189)4.19214093
36urea metabolic process (GO:0019627)4.16732699
37urea cycle (GO:0000050)4.16732699
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.15586754
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09644455
40oxidative demethylation (GO:0070989)4.09256718
41sperm capacitation (GO:0048240)4.06575726
42phenylpropanoid metabolic process (GO:0009698)4.06276928
43glyoxylate metabolic process (GO:0046487)4.05227041
44regulation of cholesterol esterification (GO:0010872)4.05176087
45bile acid biosynthetic process (GO:0006699)4.02037681
46intestinal cholesterol absorption (GO:0030299)3.99739341
47single fertilization (GO:0007338)3.96462584
48drug metabolic process (GO:0017144)3.95132075
49daunorubicin metabolic process (GO:0044597)3.89823375
50polyketide metabolic process (GO:0030638)3.89823375
51doxorubicin metabolic process (GO:0044598)3.89823375
52cellular biogenic amine catabolic process (GO:0042402)3.89441060
53amine catabolic process (GO:0009310)3.89441060
54microtubule depolymerization (GO:0007019)3.86842820
55exogenous drug catabolic process (GO:0042738)3.83745847
56cofactor catabolic process (GO:0051187)3.81014267
57nitrogen cycle metabolic process (GO:0071941)3.79078977
58quinone metabolic process (GO:1901661)3.75887983
59phospholipid efflux (GO:0033700)3.71388039
60reverse cholesterol transport (GO:0043691)3.68775878
61male meiosis (GO:0007140)3.66276847
62amino-acid betaine metabolic process (GO:0006577)3.65904572
63aromatic amino acid family metabolic process (GO:0009072)3.63933150
64pyrimidine nucleobase catabolic process (GO:0006208)3.63808875
65drug transmembrane transport (GO:0006855)3.63308564
66protein-lipid complex remodeling (GO:0034368)3.61535715
67macromolecular complex remodeling (GO:0034367)3.61535715
68plasma lipoprotein particle remodeling (GO:0034369)3.61535715
69bile acid metabolic process (GO:0008206)3.58269924
70DNA methylation involved in gamete generation (GO:0043046)3.58238214
71indolalkylamine metabolic process (GO:0006586)3.55865448
72carnitine metabolic process (GO:0009437)3.55572331
73serine family amino acid catabolic process (GO:0009071)3.54609854
74regulation of fibrinolysis (GO:0051917)3.54403214
75complement activation, alternative pathway (GO:0006957)3.53099213
76regulation of triglyceride catabolic process (GO:0010896)3.51114719
77aminoglycoside antibiotic metabolic process (GO:0030647)3.51098594
78cellular glucuronidation (GO:0052695)3.50795110
79acylglycerol homeostasis (GO:0055090)3.45034946
80triglyceride homeostasis (GO:0070328)3.45034946
81ketone body metabolic process (GO:1902224)3.44828293
82arginine metabolic process (GO:0006525)3.44789913
83sulfur amino acid catabolic process (GO:0000098)3.43838705
84peptidyl-glutamic acid modification (GO:0018200)3.43633999
85tyrosine metabolic process (GO:0006570)3.43481252
86spermatogenesis (GO:0007283)3.43206326
87male gamete generation (GO:0048232)3.41654631
88fructose metabolic process (GO:0006000)3.37702556
89nucleobase catabolic process (GO:0046113)3.35156185
90sulfate transport (GO:0008272)3.34518742
91sulfate transmembrane transport (GO:1902358)3.32164743
92regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.30692833
93omega-hydroxylase P450 pathway (GO:0097267)3.30353407
94cellular ketone body metabolic process (GO:0046950)3.30083307
95protein carboxylation (GO:0018214)3.29111479
96peptidyl-glutamic acid carboxylation (GO:0017187)3.29111479
97regulation of protein activation cascade (GO:2000257)3.27391475
98fat-soluble vitamin biosynthetic process (GO:0042362)3.26308470
99cysteine metabolic process (GO:0006534)3.26234247
100drug catabolic process (GO:0042737)3.25309377
101plasma lipoprotein particle assembly (GO:0034377)3.24700717
102negative regulation of sterol transport (GO:0032372)3.24214928
103negative regulation of cholesterol transport (GO:0032375)3.24214928
104cholesterol efflux (GO:0033344)3.23365875
105synapsis (GO:0007129)3.23275892
106bile acid and bile salt transport (GO:0015721)3.23246569
107alkaloid metabolic process (GO:0009820)3.22441356
108fertilization (GO:0009566)3.22048740
109intestinal absorption (GO:0050892)3.21962724
110alditol metabolic process (GO:0019400)3.21939603
111low-density lipoprotein particle remodeling (GO:0034374)3.21248680
112flavonoid metabolic process (GO:0009812)3.20133729
113glucuronate metabolic process (GO:0019585)3.19008636
114uronic acid metabolic process (GO:0006063)3.19008636
115NAD biosynthetic process (GO:0009435)3.17979041
116positive regulation of triglyceride lipase activity (GO:0061365)3.17806970
117positive regulation of lipoprotein lipase activity (GO:0051006)3.17806970
118heme transport (GO:0015886)3.16549831
119very-low-density lipoprotein particle assembly (GO:0034379)3.16010845
120benzene-containing compound metabolic process (GO:0042537)3.15183240
121negative regulation of fibrinolysis (GO:0051918)3.14745601
122homocysteine metabolic process (GO:0050667)3.12542095
123gamete generation (GO:0007276)3.11743936
124calcium ion-dependent exocytosis (GO:0017156)3.10968849
125alpha-amino acid catabolic process (GO:1901606)3.10587494
126male meiosis I (GO:0007141)3.08430639
127negative regulation of inclusion body assembly (GO:0090084)3.07369230
128regulation of bile acid biosynthetic process (GO:0070857)3.06896423
129negative regulation of lipase activity (GO:0060192)3.06455344
130phospholipid homeostasis (GO:0055091)3.02700628
131steroid catabolic process (GO:0006706)3.01012246
132cholesterol homeostasis (GO:0042632)3.00085117
133serine family amino acid biosynthetic process (GO:0009070)2.97859101
134vitamin biosynthetic process (GO:0009110)2.97788761
135serine family amino acid metabolic process (GO:0009069)2.96829958
136sterol homeostasis (GO:0055092)2.94273858
137ethanol oxidation (GO:0006069)2.92851412
138glutathione derivative metabolic process (GO:1901685)2.92543916
139glutathione derivative biosynthetic process (GO:1901687)2.92543916
140plasma lipoprotein particle organization (GO:0071827)2.89346347
141peroxisome fission (GO:0016559)2.86179738
142mannosylation (GO:0097502)2.81366067
143C4-dicarboxylate transport (GO:0015740)2.79906504
144secondary metabolic process (GO:0019748)2.79795791
145digestion (GO:0007586)2.78234216
146proline metabolic process (GO:0006560)2.76880462
147L-serine metabolic process (GO:0006563)2.73577388
148xenobiotic catabolic process (GO:0042178)2.71287237
149xenobiotic metabolic process (GO:0006805)2.70822329
150negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.69445479
151water-soluble vitamin biosynthetic process (GO:0042364)2.69269053
152regulation of cholesterol metabolic process (GO:0090181)2.68957544
153quinone biosynthetic process (GO:1901663)2.68809991
154glycine metabolic process (GO:0006544)2.68450823
155plasma lipoprotein particle clearance (GO:0034381)2.68276450
156S-adenosylmethionine metabolic process (GO:0046500)2.67652144
157regulation of complement activation (GO:0030449)2.66551164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.18898267
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84491200
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.63828866
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.61069038
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.39891903
6EZH2_22144423_ChIP-Seq_EOC_Human3.25035360
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08752350
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.91348698
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.82538191
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71856260
11IGF1R_20145208_ChIP-Seq_DFB_Human2.63915389
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.55031097
13VDR_22108803_ChIP-Seq_LS180_Human2.38334003
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38101045
15GBX2_23144817_ChIP-Seq_PC3_Human2.30918299
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30211556
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28567298
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.20783730
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18955632
20TAF15_26573619_Chip-Seq_HEK293_Human2.18082104
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09750511
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.09708132
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.08558662
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06925499
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06817874
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02427829
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98602611
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95225484
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94659313
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84434885
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82327258
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.80035903
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68414962
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.63417419
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.62680768
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58503976
37EWS_26573619_Chip-Seq_HEK293_Human1.57397436
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.53586685
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53155952
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.52027866
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51097285
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50743153
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49764672
44P53_22387025_ChIP-Seq_ESCs_Mouse1.48548980
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47205647
46STAT1_17558387_ChIP-Seq_HELA_Human1.46948342
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.45984508
48KDM2B_26808549_Chip-Seq_REH_Human1.45722859
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.45474715
50SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45183391
51CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44714070
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44165212
53P300_18555785_Chip-Seq_ESCs_Mouse1.41704694
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.41655518
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.41302120
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.41286773
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40771618
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39788651
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39724165
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38396411
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.38215017
62RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36329478
63ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35835105
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33748176
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.33385616
66* REST_21632747_ChIP-Seq_MESCs_Mouse1.32584392
67P300_19829295_ChIP-Seq_ESCs_Human1.32443155
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31775245
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.31669615
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.31443747
71PU1_27457419_Chip-Seq_LIVER_Mouse1.31349032
72FUS_26573619_Chip-Seq_HEK293_Human1.30834119
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29274106
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29224868
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27564967
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.25639931
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.25499928
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.25315479
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.24720043
80GABP_19822575_ChIP-Seq_HepG2_Human1.24359955
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23794215
82* TCF4_22108803_ChIP-Seq_LS180_Human1.23772407
83* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23580256
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23529863
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21886763
86NCOR_22424771_ChIP-Seq_293T_Human1.21850700
87* FOXA1_25329375_ChIP-Seq_VCAP_Human1.20987648
88* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20987648
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.20300523
90HTT_18923047_ChIP-ChIP_STHdh_Human1.20099970
91VDR_23849224_ChIP-Seq_CD4+_Human1.19504858
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19211529
93CBP_20019798_ChIP-Seq_JUKART_Human1.19211529
94* MYC_18940864_ChIP-ChIP_HL60_Human1.18949753
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18341132
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17937025
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17414087
98SMAD4_21799915_ChIP-Seq_A2780_Human1.16931659
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15773058
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.14973036
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14584542
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14358625
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13789662
104* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13238175
105IRF1_19129219_ChIP-ChIP_H3396_Human1.13189988
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12351132
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.11943552
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11685280
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11141233
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10869363
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10869363
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10811548
113REST_18959480_ChIP-ChIP_MESCs_Mouse1.09362375
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08417744
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07989696
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07768228
117AR_20517297_ChIP-Seq_VCAP_Human1.07743737
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07363340
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07194055
120AR_25329375_ChIP-Seq_VCAP_Human1.06371890
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06074162
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05435865
123AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04808676
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04640399
125RNF2_27304074_Chip-Seq_NSC_Mouse1.04140247
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.03503030
127ELK1_19687146_ChIP-ChIP_HELA_Human1.03074952
128RUNX2_22187159_ChIP-Seq_PCA_Human1.02672953
129* CDX2_22108803_ChIP-Seq_LS180_Human1.02551587
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02115062
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.01932058
132ZNF274_21170338_ChIP-Seq_K562_Hela1.01475490
133BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00433953
134TBL1_22424771_ChIP-Seq_293T_Human0.99475779
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99062192
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98579729
137* ER_23166858_ChIP-Seq_MCF-7_Human0.98259470
138STAT3_23295773_ChIP-Seq_U87_Human0.98152806
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97662650
140NFYB_21822215_ChIP-Seq_K562_Human0.96940979
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96766831
142TP53_22573176_ChIP-Seq_HFKS_Human0.96697633
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.96658850
144* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96509158
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96398722
146GATA3_21867929_ChIP-Seq_CD8_Mouse0.96295101
147GF1_26923725_Chip-Seq_HPCs_Mouse0.95729010
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94983442
149EZH2_27294783_Chip-Seq_ESCs_Mouse0.94028450
150* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93857370
151TCF4_23295773_ChIP-Seq_U87_Human0.93654825
152* BCAT_22108803_ChIP-Seq_LS180_Human0.93340248
153HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93261702
154ETV1_20927104_ChIP-Seq_GIST48_Human0.92444056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.21800525
2MP0002139_abnormal_hepatobiliary_system6.32441728
3MP0005360_urolithiasis5.92685837
4MP0005085_abnormal_gallbladder_physiolo4.72802606
5MP0005365_abnormal_bile_salt4.68031336
6MP0008875_abnormal_xenobiotic_pharmacok3.95052520
7MP0003698_abnormal_male_reproductive2.62699854
8MP0003252_abnormal_bile_duct2.57385674
9MP0003136_yellow_coat_color2.44409241
10MP0000372_irregular_coat_pigmentation2.41885273
11MP0010329_abnormal_lipoprotein_level2.39413957
12MP0001929_abnormal_gametogenesis2.29953567
13MP0004019_abnormal_vitamin_homeostasis2.23183335
14MP0005409_darkened_coat_color2.13670502
15MP0004147_increased_porphyrin_level2.11937481
16MP0009697_abnormal_copulation2.08862573
17MP0005670_abnormal_white_adipose2.02580728
18MP0005332_abnormal_amino_acid2.00402544
19MP0003806_abnormal_nucleotide_metabolis1.96729709
20MP0002876_abnormal_thyroid_physiology1.92727004
21MP0003195_calcinosis1.90250291
22MP0001666_abnormal_nutrient_absorption1.86773959
23MP0005451_abnormal_body_composition1.85068523
24MP0002138_abnormal_hepatobiliary_system1.69277171
25MP0003868_abnormal_feces_composition1.68921967
26MP0008877_abnormal_DNA_methylation1.65343084
27MP0000566_synostosis1.63363112
28MP0001764_abnormal_homeostasis1.62782483
29MP0003183_abnormal_peptide_metabolism1.54748963
30MP0002132_abnormal_respiratory_system1.47180331
31MP0002161_abnormal_fertility/fecundity1.45231246
32MP0002118_abnormal_lipid_homeostasis1.40719777
33MP0002909_abnormal_adrenal_gland1.33641693
34MP0005636_abnormal_mineral_homeostasis1.33547239
35MP0001984_abnormal_olfaction1.29152429
36MP0009840_abnormal_foam_cell1.28846044
37MP0002210_abnormal_sex_determination1.27571628
38MP0000609_abnormal_liver_physiology1.25322858
39MP0005647_abnormal_sex_gland1.24430722
40MP0003191_abnormal_cellular_cholesterol1.24382090
41MP0005389_reproductive_system_phenotype1.21163586
42MP0004264_abnormal_extraembryonic_tissu1.19318314
43MP0005377_hearing/vestibular/ear_phenot1.19146034
44MP0003878_abnormal_ear_physiology1.19146034
45MP0004043_abnormal_pH_regulation1.17845152
46MP0000015_abnormal_ear_pigmentation1.17732302
47MP0002938_white_spotting1.15106569
48MP0005319_abnormal_enzyme/_coenzyme1.12965586
49MP0001664_abnormal_digestion1.10138795
50MP0005083_abnormal_biliary_tract1.09887937
51MP0005084_abnormal_gallbladder_morpholo1.09831911
52MP0008058_abnormal_DNA_repair1.08871798
53MP0002090_abnormal_vision1.07499529
54MP0004270_analgesia1.06926719
55MP0005646_abnormal_pituitary_gland1.06867151
56MP0005408_hypopigmentation1.06179072
57MP0005584_abnormal_enzyme/coenzyme_acti1.05320626
58MP0001145_abnormal_male_reproductive1.04742003
59MP0000653_abnormal_sex_gland1.02267240
60MP0001986_abnormal_taste_sensitivity1.02262409
61MP0003890_abnormal_embryonic-extraembry1.01443163
62MP0003880_abnormal_central_pattern1.01203761
63MP0002822_catalepsy1.00978670
64MP0001188_hyperpigmentation0.99053748
65MP0002102_abnormal_ear_morphology0.97517554
66MP0005535_abnormal_body_temperature0.96252154
67MP0009764_decreased_sensitivity_to0.94679769
68MP0003122_maternal_imprinting0.93603265
69MP0006035_abnormal_mitochondrial_morpho0.92398364
70MP0005423_abnormal_somatic_nervous0.91206793
71MP0009643_abnormal_urine_homeostasis0.91073267
72MP0002736_abnormal_nociception_after0.90534858
73MP0006036_abnormal_mitochondrial_physio0.89757811
74MP0003879_abnormal_hair_cell0.89502940
75MP0003567_abnormal_fetal_cardiomyocyte0.89055678
76MP0005075_abnormal_melanosome_morpholog0.88339082
77MP0005253_abnormal_eye_physiology0.87911219
78MP0002735_abnormal_chemical_nociception0.87879212
79MP0002009_preneoplasia0.87762834
80MP0001661_extended_life_span0.87078808
81MP0004381_abnormal_hair_follicle0.86531960
82MP0000639_abnormal_adrenal_gland0.86390077
83MP0000778_abnormal_nervous_system0.83603636
84MP0002928_abnormal_bile_duct0.83539689
85MP0001486_abnormal_startle_reflex0.83438239
86MP0005551_abnormal_eye_electrophysiolog0.81755637
87MP0001765_abnormal_ion_homeostasis0.80490506
88MP0005187_abnormal_penis_morphology0.78378361
89MP0001529_abnormal_vocalization0.76644122
90MP0009379_abnormal_foot_pigmentation0.76527086
91MP0008995_early_reproductive_senescence0.75651286
92MP0000538_abnormal_urinary_bladder0.74781239
93MP0005174_abnormal_tail_pigmentation0.74215614
94MP0006276_abnormal_autonomic_nervous0.74115252
95MP0005171_absent_coat_pigmentation0.74028090
96MP0006292_abnormal_olfactory_placode0.73432473
97MP0003724_increased_susceptibility_to0.73126804
98MP0002160_abnormal_reproductive_system0.72072169
99MP0001919_abnormal_reproductive_system0.71545074
100MP0005386_behavior/neurological_phenoty0.71509166
101MP0004924_abnormal_behavior0.71509166
102MP0002971_abnormal_brown_adipose0.71334491
103MP0001968_abnormal_touch/_nociception0.71215242
104MP0004142_abnormal_muscle_tone0.71022114
105MP0009765_abnormal_xenobiotic_induced0.70751699
106MP0000598_abnormal_liver_morphology0.69984176
107MP0003941_abnormal_skin_development0.69337738
108* MP0009642_abnormal_blood_homeostasis0.68987375
109MP0003943_abnormal_hepatobiliary_system0.67587529
110MP0002078_abnormal_glucose_homeostasis0.67460179
111MP0001963_abnormal_hearing_physiology0.67262418
112MP0000647_abnormal_sebaceous_gland0.66573389
113MP0005645_abnormal_hypothalamus_physiol0.65076974
114MP0001905_abnormal_dopamine_level0.64649642
115MP0003011_delayed_dark_adaptation0.64625554
116MP0009745_abnormal_behavioral_response0.64588663
117MP0002229_neurodegeneration0.63900718
118MP0004742_abnormal_vestibular_system0.63300574
119MP0003718_maternal_effect0.62324215
120MP0002064_seizures0.62200521
121MP0000427_abnormal_hair_cycle0.62156688
122MP0001440_abnormal_grooming_behavior0.61731258
123MP0003329_amyloid_beta_deposits0.61103149
124MP0000026_abnormal_inner_ear0.61035525
125MP0002572_abnormal_emotion/affect_behav0.60511525
126MP0005448_abnormal_energy_balance0.59888857
127MP0001501_abnormal_sleep_pattern0.59834807
128MP0001324_abnormal_eye_pigmentation0.59301203
129MP0005248_abnormal_Harderian_gland0.58287257
130MP0003186_abnormal_redox_activity0.57928591
131MP0002272_abnormal_nervous_system0.57086877
132MP0005379_endocrine/exocrine_gland_phen0.56149950
133MP0000604_amyloidosis0.55651268
134MP0009763_increased_sensitivity_to0.53699885
135MP0008469_abnormal_protein_level0.53097283
136MP0003953_abnormal_hormone_level0.53010940
137MP0005334_abnormal_fat_pad0.51953774
138MP0003959_abnormal_lean_body0.51714197
139MP0002557_abnormal_social/conspecific_i0.51549398
140MP0002638_abnormal_pupillary_reflex0.49605256

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.15313188
2Absent/shortened dynein arms (HP:0200106)7.75332888
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.75332888
4Abnormal respiratory motile cilium physiology (HP:0012261)5.46728292
5Abnormal respiratory motile cilium morphology (HP:0005938)5.38121379
6Abnormal respiratory epithelium morphology (HP:0012253)5.38121379
7Prolonged partial thromboplastin time (HP:0003645)4.61211409
8Rhinitis (HP:0012384)4.27871372
9Abnormal ciliary motility (HP:0012262)4.27385080
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.21483162
11Intrahepatic cholestasis (HP:0001406)4.09438974
12Chronic bronchitis (HP:0004469)3.93132022
13Hypobetalipoproteinemia (HP:0003563)3.61868201
14Infertility (HP:0000789)3.55284929
15Joint hemorrhage (HP:0005261)3.46757976
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44074081
17Deep venous thrombosis (HP:0002625)3.34107842
18Conjugated hyperbilirubinemia (HP:0002908)3.19412940
19Type II lissencephaly (HP:0007260)3.14157008
20Abnormality of alanine metabolism (HP:0010916)3.01712147
21Hyperalaninemia (HP:0003348)3.01712147
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01712147
23Hyperglycinemia (HP:0002154)3.00611275
24Abnormality of proline metabolism (HP:0010907)2.98047411
25Hydroxyprolinuria (HP:0003080)2.98047411
26Complement deficiency (HP:0004431)2.95031082
27Delayed CNS myelination (HP:0002188)2.93208113
28Xanthomatosis (HP:0000991)2.91845818
29Tubulointerstitial nephritis (HP:0001970)2.81916953
30Osteomalacia (HP:0002749)2.81674261
31Fat malabsorption (HP:0002630)2.78597719
32Hyperglycinuria (HP:0003108)2.75102006
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73662327
34Polyphagia (HP:0002591)2.71687367
35Amblyopia (HP:0000646)2.70024324
36Cerebellar dysplasia (HP:0007033)2.66200138
37Ketosis (HP:0001946)2.64358991
38Sensorimotor neuropathy (HP:0007141)2.63563195
39Brushfield spots (HP:0001088)2.63211978
40Nephronophthisis (HP:0000090)2.62743862
41Hypercholesterolemia (HP:0003124)2.61159127
42Hypoplasia of the thymus (HP:0000778)2.60908364
43Hyperlipoproteinemia (HP:0010980)2.59926503
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.57998818
45Epidermoid cyst (HP:0200040)2.56393476
46Abnormal biliary tract physiology (HP:0012439)2.56180395
47Bile duct proliferation (HP:0001408)2.56180395
48Abnormality of methionine metabolism (HP:0010901)2.53531581
49Bronchiectasis (HP:0002110)2.53370112
50Abnormality of serine family amino acid metabolism (HP:0010894)2.52834581
51Abnormality of glycine metabolism (HP:0010895)2.52834581
52Hyperphosphaturia (HP:0003109)2.47050029
53Hemorrhage of the eye (HP:0011885)2.43714441
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.40699602
55Abnormality of the renal cortex (HP:0011035)2.39973616
56Hypolipoproteinemia (HP:0010981)2.39666809
57Abnormality of the renal medulla (HP:0100957)2.36991545
58Generalized aminoaciduria (HP:0002909)2.35552247
59Abnormality of pyrimidine metabolism (HP:0004353)2.33709508
60Abnormal urine phosphate concentration (HP:0012599)2.31037208
61Enlarged kidneys (HP:0000105)2.30284227
62Abnormal spermatogenesis (HP:0008669)2.30282156
63Hyperammonemia (HP:0001987)2.29724814
64Hyperinsulinemic hypoglycemia (HP:0000825)2.28560771
65Decreased central vision (HP:0007663)2.26705970
66Impulsivity (HP:0100710)2.26641943
67Renal cortical cysts (HP:0000803)2.24671887
68Tubulointerstitial abnormality (HP:0001969)2.21545936
69Chronic hepatic failure (HP:0100626)2.19777481
70Epiphyseal stippling (HP:0010655)2.17893693
71Cerebral edema (HP:0002181)2.16972454
72Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15741446
73Confusion (HP:0001289)2.15616341
74Acute encephalopathy (HP:0006846)2.14631666
75Dicarboxylic aciduria (HP:0003215)2.14516850
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14516850
77Proximal tubulopathy (HP:0000114)2.12173130
78Hypoglycemic seizures (HP:0002173)2.11353100
79Vascular calcification (HP:0004934)2.10916881
80Recurrent sinusitis (HP:0011108)2.10700347
81Reduced antithrombin III activity (HP:0001976)2.10656419
82Steatorrhea (HP:0002570)2.10521837
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10107546
84Impaired vibration sensation in the lower limbs (HP:0002166)2.09579355
85Abnormality of the common coagulation pathway (HP:0010990)2.09244363
86Abnormality of midbrain morphology (HP:0002418)2.08898404
87Molar tooth sign on MRI (HP:0002419)2.08898404
88Abnormality of nucleobase metabolism (HP:0010932)2.07879797
89Hyperbilirubinemia (HP:0002904)2.07463011
90Chorioretinal atrophy (HP:0000533)2.07105393
913-Methylglutaconic aciduria (HP:0003535)2.05170244
92Azoospermia (HP:0000027)2.05151749
93True hermaphroditism (HP:0010459)2.05029044
94Cholecystitis (HP:0001082)2.03802695
95Abnormal gallbladder physiology (HP:0012438)2.03802695
96Abnormality of the corticospinal tract (HP:0002492)2.03772789
97Lissencephaly (HP:0001339)2.03767362
98Gait imbalance (HP:0002141)2.03511906
99Patchy hypopigmentation of hair (HP:0011365)2.03480774
100Spontaneous abortion (HP:0005268)2.02505087
101Hypoglycemic coma (HP:0001325)2.02144614
102Hypoplasia of the uterus (HP:0000013)2.00777858
103Retinal dysplasia (HP:0007973)2.00752690
104Nasal polyposis (HP:0100582)1.98922858
105Abnormality of complement system (HP:0005339)1.98920131
106Congenital primary aphakia (HP:0007707)1.96347040
107Abnormality of serum amino acid levels (HP:0003112)1.95787660
108Abnormality of purine metabolism (HP:0004352)1.94964941
109Increased serum pyruvate (HP:0003542)1.93812803
110White forelock (HP:0002211)1.93483208
111Abnormality of the vitamin B12 metabolism (HP:0004341)1.93427948
112Abnormality of the intrinsic pathway (HP:0010989)1.90567459
113Gonadal dysgenesis (HP:0000133)1.90470378
114Gout (HP:0001997)1.89589307
115Abnormality of vitamin metabolism (HP:0100508)1.88818631
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86337426
117Intestinal atresia (HP:0011100)1.85887741
118Male pseudohermaphroditism (HP:0000037)1.85514612
119Male infertility (HP:0003251)1.84751690
120Recurrent otitis media (HP:0000403)1.84611313
121Bony spicule pigmentary retinopathy (HP:0007737)1.84440647
122Nephrogenic diabetes insipidus (HP:0009806)1.84187647
123Fair hair (HP:0002286)1.84175359
124Hypothermia (HP:0002045)1.84083527
125Hypoalphalipoproteinemia (HP:0003233)1.83911087
126Medial flaring of the eyebrow (HP:0010747)1.83791080
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.83693492
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83693492
129Bronchitis (HP:0012387)1.83093119
130Abnormality of vitamin B metabolism (HP:0004340)1.82904709
131Metabolic acidosis (HP:0001942)1.81016073
132Lipid accumulation in hepatocytes (HP:0006561)1.80709322
133Hypophosphatemic rickets (HP:0004912)1.80286913
134Acanthocytosis (HP:0001927)1.78692104
135Aplasia/hypoplasia of the uterus (HP:0008684)1.77963695
136Congenital hepatic fibrosis (HP:0002612)1.77654310
137Abnormality of fatty-acid metabolism (HP:0004359)1.74853488
138Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74003516
139Hypoplasia of the brainstem (HP:0002365)1.74003516
140Hyperventilation (HP:0002883)1.72180729
141Malnutrition (HP:0004395)1.71319883
142Amyotrophic lateral sclerosis (HP:0007354)1.71047529
143Increased hepatocellular lipid droplets (HP:0006565)1.69758120
144Lethargy (HP:0001254)1.69657049
145Glycosuria (HP:0003076)1.68127573
146Abnormality of urine glucose concentration (HP:0011016)1.68127573
147Delayed myelination (HP:0012448)1.67548760
148Abnormality of glycolysis (HP:0004366)1.67490113
149Congenital stationary night blindness (HP:0007642)1.66903435
150Abnormality of renal resorption (HP:0011038)1.66556116
151Abnormality of renal excretion (HP:0011036)1.65916977
152Prolonged neonatal jaundice (HP:0006579)1.65411447
153Cardiovascular calcification (HP:0011915)1.64679683
154Symptomatic seizures (HP:0011145)1.63898546
155Alkalosis (HP:0001948)1.62146189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.08539583
2PDK44.08539583
3PRKD33.84985333
4ACVR1B3.84251497
5CDK193.83801191
6INSRR3.46153808
7BCR3.24602740
8EPHA42.95826972
9TNIK2.89279680
10TRIM282.82584568
11PNCK2.72339559
12PDK22.67154449
13MAP3K42.54026330
14TESK12.42109655
15CASK2.28379235
16ICK2.26720375
17IRAK11.98266535
18WNK41.94621334
19ERBB31.92851469
20STK391.90069422
21CSNK1G21.80785190
22CSNK1G31.80760176
23MAP2K71.80135976
24TXK1.76056190
25CSNK1G11.64087111
26STK38L1.63767954
27RIPK41.58222720
28CSNK1A1L1.55694275
29STK161.48983713
30MAPK151.48326040
31STK381.48079420
32BMPR21.46559527
33PTK2B1.43808750
34NEK11.41752845
35YES11.36710404
36PIM21.36078404
37IRAK21.34789066
38FRK1.30643517
39ADRBK21.30258765
40PLK21.29707626
41MAP4K21.28165868
42PINK11.26129330
43GRK11.25564926
44CAMK1G1.24950184
45PKN11.22882942
46WEE11.22378178
47BMPR1B1.21426383
48MKNK21.19760022
49VRK11.14868838
50ZAK1.11308187
51CDK31.10598822
52TESK21.08443773
53CLK11.06161953
54TIE11.05098123
55TSSK61.04087394
56BCKDK1.00970441
57EIF2AK31.00865085
58MUSK1.00572284
59NEK20.99937512
60MATK0.93267803
61MAPK130.91975900
62PRKCG0.91624590
63KSR10.91096877
64NTRK30.90489611
65EIF2AK10.88760105
66CSF1R0.88043582
67IRAK30.86400824
68OXSR10.85700455
69MET0.85640537
70WNK30.84281983
71NME10.82434170
72PRKG20.81953754
73CAMK10.81765087
74DYRK1B0.80734697
75IRAK40.79938372
76NEK60.77892011
77PBK0.77451498
78AKT30.75409395
79PRKCQ0.74489854
80SIK20.74425284
81EPHA30.73526324
82PLK30.71471655
83EIF2AK20.67182679
84PLK10.66099822
85MINK10.65997585
86TAOK30.62856183
87MAP3K30.62392358
88PRKAA20.61946606
89FGFR40.60829978
90CAMK2A0.60390711
91MAP3K50.59793659
92RPS6KA50.58582295
93NLK0.58297088
94BRD40.57502588
95DAPK20.57071188
96BRSK20.56611829
97DAPK10.56534950
98CAMKK20.56294225
99PAK30.56155075
100PAK60.55747035
101MAP2K60.53399068
102TEC0.53256157
103PDK10.53178148
104MAP3K140.52160607
105MARK10.51555931
106GRK70.50384261
107CHEK20.48160407
108CSNK1D0.47625052
109MARK20.47438509
110MKNK10.47364541
111MAP3K60.46654757
112NTRK20.46374311
113MAPK40.45831059
114KIT0.45660656
115CDK140.44326822
116FLT30.44234836
117TAF10.43836868
118STK30.43290426
119BRSK10.42647896
120PRKCZ0.41955448
121FGFR20.41676684
122FGR0.41492300
123PRKAA10.41014964
124DYRK20.40592960
125CDK70.39880717
126CSNK1E0.39842685
127CAMK2B0.39356529
128ATR0.38924372
129DYRK30.38701070
130PRKCI0.37830273
131MAPKAPK30.37252217
132GRK60.36626481
133MST1R0.36275352
134PRKCE0.36187557
135MAP2K40.36158939
136DYRK1A0.36153094
137PRKCA0.35769155
138GRK50.35291411
139PRKACA0.35134003
140CDK11A0.34545011
141WNK10.33190102
142TTK0.32361664
143ERBB40.32245641
144PRKACG0.31714915
145LYN0.29291482
146SYK0.29248953
147PDPK10.28439225
148RPS6KB10.27704096
149SRPK10.27094078
150NUAK10.27012899
151MAPK70.26590733
152PRKCB0.25669057
153PRKG10.25034766
154MAPKAPK50.23409458

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.46508272
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94718022
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56225379
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55309995
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30307517
6Tryptophan metabolism_Homo sapiens_hsa003802.19971985
7Histidine metabolism_Homo sapiens_hsa003402.18920992
8Vitamin B6 metabolism_Homo sapiens_hsa007502.16573831
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16398694
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.14010005
11Chemical carcinogenesis_Homo sapiens_hsa052042.07492876
12Peroxisome_Homo sapiens_hsa041462.06663838
13Complement and coagulation cascades_Homo sapiens_hsa046102.05191519
14Propanoate metabolism_Homo sapiens_hsa006402.03861611
15Fatty acid degradation_Homo sapiens_hsa000712.01326716
16Vitamin digestion and absorption_Homo sapiens_hsa049771.98500072
17Arginine biosynthesis_Homo sapiens_hsa002201.96478992
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95197537
19Nitrogen metabolism_Homo sapiens_hsa009101.91523925
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90924470
21Linoleic acid metabolism_Homo sapiens_hsa005911.90119647
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88249354
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86014398
24PPAR signaling pathway_Homo sapiens_hsa033201.85526986
25Butanoate metabolism_Homo sapiens_hsa006501.82159868
26Retinol metabolism_Homo sapiens_hsa008301.77535691
27Sulfur metabolism_Homo sapiens_hsa009201.71422695
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.68895222
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.65791850
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64206955
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62800745
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60857217
33Fatty acid metabolism_Homo sapiens_hsa012121.60283064
34Fatty acid elongation_Homo sapiens_hsa000621.58733263
35Selenocompound metabolism_Homo sapiens_hsa004501.58522566
36beta-Alanine metabolism_Homo sapiens_hsa004101.56097098
37Fat digestion and absorption_Homo sapiens_hsa049751.49182564
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46697027
39Bile secretion_Homo sapiens_hsa049761.45808451
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45677755
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45418982
42ABC transporters_Homo sapiens_hsa020101.43770491
43Pyruvate metabolism_Homo sapiens_hsa006201.43763883
44Starch and sucrose metabolism_Homo sapiens_hsa005001.38321318
45Phenylalanine metabolism_Homo sapiens_hsa003601.33702453
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31728319
47Fatty acid biosynthesis_Homo sapiens_hsa000611.30429295
48Staphylococcus aureus infection_Homo sapiens_hsa051501.27526765
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26584914
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22810955
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21586133
52Tyrosine metabolism_Homo sapiens_hsa003501.16813869
53Glycerolipid metabolism_Homo sapiens_hsa005611.15134413
54Steroid biosynthesis_Homo sapiens_hsa001001.12550634
55Renin-angiotensin system_Homo sapiens_hsa046141.11689005
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02430131
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02370915
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.01932279
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00683873
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.99830171
61Folate biosynthesis_Homo sapiens_hsa007900.98760080
62Mineral absorption_Homo sapiens_hsa049780.97607209
63Ether lipid metabolism_Homo sapiens_hsa005650.94289580
64Arachidonic acid metabolism_Homo sapiens_hsa005900.93173976
65Arginine and proline metabolism_Homo sapiens_hsa003300.92402741
66Glutathione metabolism_Homo sapiens_hsa004800.90256777
67Caffeine metabolism_Homo sapiens_hsa002320.78039712
68Metabolic pathways_Homo sapiens_hsa011000.72283316
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68251296
70Protein digestion and absorption_Homo sapiens_hsa049740.64036074
71Nicotine addiction_Homo sapiens_hsa050330.61448208
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59562964
73Pancreatic secretion_Homo sapiens_hsa049720.58454002
74Parkinsons disease_Homo sapiens_hsa050120.53827674
75Glucagon signaling pathway_Homo sapiens_hsa049220.52574869
76Carbon metabolism_Homo sapiens_hsa012000.51257373
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.47761117
78Regulation of autophagy_Homo sapiens_hsa041400.47625096
79Pentose phosphate pathway_Homo sapiens_hsa000300.47621301
80Fructose and mannose metabolism_Homo sapiens_hsa000510.45290025
81Oxidative phosphorylation_Homo sapiens_hsa001900.43831135
82N-Glycan biosynthesis_Homo sapiens_hsa005100.43098952
83Lysine degradation_Homo sapiens_hsa003100.42790042
84Protein export_Homo sapiens_hsa030600.42292033
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41410032
86Biosynthesis of amino acids_Homo sapiens_hsa012300.41276541
87Sulfur relay system_Homo sapiens_hsa041220.39802618
88Collecting duct acid secretion_Homo sapiens_hsa049660.36783228
89Taste transduction_Homo sapiens_hsa047420.36454734
90Serotonergic synapse_Homo sapiens_hsa047260.36088974
91RNA degradation_Homo sapiens_hsa030180.35600452
92Cocaine addiction_Homo sapiens_hsa050300.35052152
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32255591
94GABAergic synapse_Homo sapiens_hsa047270.30823023
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30553962
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30111206
97Amphetamine addiction_Homo sapiens_hsa050310.28309966
98Dopaminergic synapse_Homo sapiens_hsa047280.26816903
99Sphingolipid metabolism_Homo sapiens_hsa006000.25082728
100RNA polymerase_Homo sapiens_hsa030200.22079438
101Insulin secretion_Homo sapiens_hsa049110.21903943
102Non-homologous end-joining_Homo sapiens_hsa034500.18512157
103Purine metabolism_Homo sapiens_hsa002300.18243505
104Huntingtons disease_Homo sapiens_hsa050160.17911881
105Fanconi anemia pathway_Homo sapiens_hsa034600.17742136
106African trypanosomiasis_Homo sapiens_hsa051430.16380522
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16216453
108Basal transcription factors_Homo sapiens_hsa030220.15880953
109Ovarian steroidogenesis_Homo sapiens_hsa049130.14191612
110Primary immunodeficiency_Homo sapiens_hsa053400.13956313
111Alzheimers disease_Homo sapiens_hsa050100.13110568
112Pyrimidine metabolism_Homo sapiens_hsa002400.12910100
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12765007
114Dorso-ventral axis formation_Homo sapiens_hsa043200.12638274
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.10549984
116Glutamatergic synapse_Homo sapiens_hsa047240.10052164
117Galactose metabolism_Homo sapiens_hsa000520.08733383

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