AQP12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)8.40647316
2transcytosis (GO:0045056)8.30303778
3negative regulation of epidermal cell differentiation (GO:0045605)7.52366058
4intestinal absorption (GO:0050892)7.24941962
5fusion of sperm to egg plasma membrane (GO:0007342)7.22752365
6icosanoid secretion (GO:0032309)6.87081893
7arachidonic acid secretion (GO:0050482)6.87081893
8sperm motility (GO:0030317)6.79092104
9neutrophil mediated immunity (GO:0002446)6.33150300
10acrosome reaction (GO:0007340)6.21934235
11phosphatidylinositol acyl-chain remodeling (GO:0036149)5.88774033
12fatty acid derivative transport (GO:1901571)5.79381228
13icosanoid transport (GO:0071715)5.79381228
14negative regulation of epidermis development (GO:0045683)5.78460961
15phosphatidylserine acyl-chain remodeling (GO:0036150)5.72271587
16sperm capacitation (GO:0048240)5.62080423
17phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.53693735
18membrane lipid catabolic process (GO:0046466)5.48581855
19plasma membrane fusion (GO:0045026)5.44282412
20glycolipid catabolic process (GO:0019377)5.38921232
21protein targeting to Golgi (GO:0000042)5.38401041
22establishment of protein localization to Golgi (GO:0072600)5.26625463
23cholesterol catabolic process (GO:0006707)5.23861103
24sterol catabolic process (GO:0016127)5.23861103
25ceramide catabolic process (GO:0046514)5.18140811
26mitochondrial calcium ion transport (GO:0006851)5.17717878
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.11582392
28regulation of cholesterol homeostasis (GO:2000188)5.05140178
29myeloid leukocyte mediated immunity (GO:0002444)4.51614496
30regulation of guanylate cyclase activity (GO:0031282)4.40796069
31cell wall macromolecule metabolic process (GO:0044036)4.38231844
32atrioventricular valve morphogenesis (GO:0003181)4.32014675
33regulation of bile acid biosynthetic process (GO:0070857)4.31398831
34multicellular organism reproduction (GO:0032504)4.23978282
35leukotriene biosynthetic process (GO:0019370)4.21765719
36innate immune response in mucosa (GO:0002227)4.15570989
37positive regulation of guanylate cyclase activity (GO:0031284)4.12382243
38DNA packaging (GO:0006323)4.09886352
39protein polyglutamylation (GO:0018095)4.08305483
40chromosome condensation (GO:0030261)4.06620434
41spermatid development (GO:0007286)4.03081816
42regulation of keratinocyte differentiation (GO:0045616)4.00759592
43tetrapyrrole metabolic process (GO:0033013)4.00581577
44reproduction (GO:0000003)3.97777366
45protein localization to Golgi apparatus (GO:0034067)3.97046356
46antibacterial humoral response (GO:0019731)3.92966644
47phosphatidylethanolamine biosynthetic process (GO:0006646)3.91150335
48microtubule depolymerization (GO:0007019)3.86842420
49phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.85650209
50sexual reproduction (GO:0019953)3.84084541
51seminiferous tubule development (GO:0072520)3.79820717
52peptidyl-proline hydroxylation (GO:0019511)3.75648620
53regulation of keratinocyte proliferation (GO:0010837)3.73135717
54antimicrobial humoral response (GO:0019730)3.72845613
55glomerular visceral epithelial cell development (GO:0072015)3.65462938
56calcium ion-dependent exocytosis (GO:0017156)3.64363008
57sperm-egg recognition (GO:0035036)3.62519658
58mucosal immune response (GO:0002385)3.61425038
59protein retention in ER lumen (GO:0006621)3.60405731
60phosphatidylethanolamine metabolic process (GO:0046337)3.54690981
61digestive system process (GO:0022600)3.54213411
62single strand break repair (GO:0000012)3.48764416
63cellular ketone body metabolic process (GO:0046950)3.47513932
64spermatogenesis (GO:0007283)3.47452498
65male gamete generation (GO:0048232)3.46351976
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.44855435
67negative regulation of inclusion body assembly (GO:0090084)3.38127472
68response to pheromone (GO:0019236)3.35698490
69spermatid nucleus differentiation (GO:0007289)3.34664082
70microtubule polymerization or depolymerization (GO:0031109)3.33520609
71glomerular epithelial cell development (GO:0072310)3.32486005
72phosphatidic acid biosynthetic process (GO:0006654)3.30815261
73phosphatidic acid metabolic process (GO:0046473)3.30815261
74cilium or flagellum-dependent cell motility (GO:0001539)3.26025757
75sphingolipid catabolic process (GO:0030149)3.25652875
76organ or tissue specific immune response (GO:0002251)3.25248085
77phosphatidylserine metabolic process (GO:0006658)3.23580387
78phosphatidylcholine acyl-chain remodeling (GO:0036151)3.19369032
79gamete generation (GO:0007276)3.18456953
80microtubule severing (GO:0051013)3.16936054
81regulation of transcription involved in cell fate commitment (GO:0060850)3.16771334
82rRNA methylation (GO:0031167)3.15786639
83cell-cell recognition (GO:0009988)3.12953638
84water-soluble vitamin metabolic process (GO:0006767)3.11037763
85macroautophagy (GO:0016236)3.10820480
86RNA destabilization (GO:0050779)3.10719965
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09961250
88long-chain fatty acid transport (GO:0015909)3.04975224
89L-alpha-amino acid transmembrane transport (GO:1902475)3.04101001
90ketone body metabolic process (GO:1902224)3.02256072
91axonemal dynein complex assembly (GO:0070286)3.00203397
92alanine transport (GO:0032328)2.98924620
93defense response to Gram-positive bacterium (GO:0050830)2.97999675
94defense response to Gram-negative bacterium (GO:0050829)2.97375193
95mitochondrion distribution (GO:0048311)2.96545075
96leukotriene metabolic process (GO:0006691)2.93057449
97regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.89177290
98digestion (GO:0007586)14.5301983
99intestinal cholesterol absorption (GO:0030299)13.2050146
100cobalamin metabolic process (GO:0009235)13.0920386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21257129
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05765245
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat13.2794446
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96427557
5IRF8_22096565_ChIP-ChIP_GC-B_Human1.90839359
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85686211
7EGR1_19032775_ChIP-ChIP_M12_Human1.70686544
8GATA4_25053715_ChIP-Seq_YYC3_Human1.65711003
9ETV1_20927104_ChIP-Seq_GIST48_Human1.59848350
10HNFA_21074721_ChIP-Seq_CACO-2_Human1.59800487
11CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.54660908
12RBPJ_21746931_ChIP-Seq_IB4_Human1.53857224
13ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52781272
14CBX2_22325352_ChIP-Seq_293T-Rex_Human1.50731753
15PHF8_20622853_ChIP-Seq_HELA_Human1.46485931
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.44060225
17GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.41737051
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37737074
19GATA6_21074721_ChIP-Seq_CACO-2_Human1.37330094
20EZH2_22144423_ChIP-Seq_EOC_Human1.35440788
21DROSHA_22980978_ChIP-Seq_HELA_Human1.35110176
22NFYA_21822215_ChIP-Seq_K562_Human1.35055615
23CTCF_27219007_Chip-Seq_Bcells_Human1.34281261
24NFYB_21822215_ChIP-Seq_K562_Human1.33568405
25* ERA_21632823_ChIP-Seq_H3396_Human1.33242721
26PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33017418
27EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32148398
28TAF2_19829295_ChIP-Seq_ESCs_Human1.29600849
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.28887185
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.26006448
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21687390
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21687390
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21687390
34MYC_19829295_ChIP-Seq_ESCs_Human1.18865785
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18790733
36GATA6_25053715_ChIP-Seq_YYC3_Human1.17705284
37NANOG_20526341_ChIP-Seq_ESCs_Human1.15471496
38SA1_27219007_Chip-Seq_Bcells_Human1.13851546
39CBP_20019798_ChIP-Seq_JUKART_Human1.13650996
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13650996
41TBL1_22424771_ChIP-Seq_293T_Human1.13568016
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.13262814
43CEBPB_22108803_ChIP-Seq_LS180_Human1.09861699
44SOX2_21211035_ChIP-Seq_LN229_Human1.08319733
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08173362
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08173362
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.05825137
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05127665
49CTCF_20526341_ChIP-Seq_ESCs_Human1.03402393
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02892459
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02670203
52* BCOR_27268052_Chip-Seq_Bcells_Human0.99813411
53TP63_22573176_ChIP-Seq_HFKS_Human0.99335238
54RAC3_21632823_ChIP-Seq_H3396_Human0.98497328
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98233256
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97372399
57ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96216734
58OCT4_20526341_ChIP-Seq_ESCs_Human0.96003241
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95566181
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95352378
61JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95326594
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94834792
63LXR_22292898_ChIP-Seq_THP-1_Human0.94767971
64AHR_22903824_ChIP-Seq_MCF-7_Human0.94230033
65P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93755264
66LXR_22158963_ChIP-Seq_LIVER_Mouse0.93505283
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90324558
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90301828
69SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90076602
70ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90051365
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89759367
72* P300_27268052_Chip-Seq_Bcells_Human0.89756192
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88858468
74TP53_18474530_ChIP-ChIP_U2OS_Human0.88525356
75* P68_20966046_ChIP-Seq_HELA_Human0.88324581
76PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87826635
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.86672749
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86002847
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85826643
80RUNX_20019798_ChIP-Seq_JUKART_Human0.85673378
81AR_25329375_ChIP-Seq_VCAP_Human0.85537983
82SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84821503
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84692706
84* BCL6_27268052_Chip-Seq_Bcells_Human0.84022979
85PHF8_20622854_ChIP-Seq_HELA_Human0.83789953
86KLF5_25053715_ChIP-Seq_YYC3_Human0.82471104
87ESET_19884257_ChIP-Seq_ESCs_Mouse0.82392124
88KLF4_19829295_ChIP-Seq_ESCs_Human0.81832824
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81628991
90WDR5_24793694_ChIP-Seq_LNCAP_Human0.81427038
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80834319
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.80606143
93ER_23166858_ChIP-Seq_MCF-7_Human0.80384931
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80355523
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.80030698
96P300_19829295_ChIP-Seq_ESCs_Human0.79923348
97GF1_26923725_Chip-Seq_HPCs_Mouse0.78816160
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.78458088
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.78207856
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.77972587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition7.15605791
2MP0005365_abnormal_bile_salt6.15427416
3MP0005410_abnormal_fertilization4.93776934
4MP0005670_abnormal_white_adipose4.04067534
5MP0005083_abnormal_biliary_tract3.88395509
6MP0005377_hearing/vestibular/ear_phenot3.41832657
7MP0003878_abnormal_ear_physiology3.41832657
8MP0005085_abnormal_gallbladder_physiolo2.72094236
9MP0005220_abnormal_exocrine_pancreas2.71245125
10MP0002138_abnormal_hepatobiliary_system2.50354232
11MP0010329_abnormal_lipoprotein_level2.25897566
12MP0001666_abnormal_nutrient_absorption10.6551914
13MP0001485_abnormal_pinna_reflex1.98757199
14MP0003959_abnormal_lean_body1.98122116
15MP0003879_abnormal_hair_cell1.80530236
16MP0008004_abnormal_stomach_pH1.79478433
17MP0003698_abnormal_male_reproductive1.66908386
18MP0002693_abnormal_pancreas_physiology1.59364976
19MP0002118_abnormal_lipid_homeostasis1.53401434
20MP0005084_abnormal_gallbladder_morpholo1.53075482
21MP0005448_abnormal_energy_balance1.38739846
22MP0001929_abnormal_gametogenesis1.31836840
23MP0003011_delayed_dark_adaptation1.30375712
24MP0002139_abnormal_hepatobiliary_system1.23469155
25MP0004264_abnormal_extraembryonic_tissu1.20081709
26MP0001501_abnormal_sleep_pattern1.18373060
27MP0002132_abnormal_respiratory_system1.17171360
28MP0000613_abnormal_salivary_gland1.16445555
29MP0001664_abnormal_digestion1.15046789
30MP0001765_abnormal_ion_homeostasis1.09999228
31MP0000678_abnormal_parathyroid_gland1.07720315
32MP0003183_abnormal_peptide_metabolism1.06197938
33MP0005452_abnormal_adipose_tissue1.00422044
34MP0005666_abnormal_adipose_tissue0.98436029
35MP0005451_abnormal_body_composition0.94126991
36MP0009115_abnormal_fat_cell0.92232087
37MP0002876_abnormal_thyroid_physiology0.91883768
38MP0001348_abnormal_lacrimal_gland0.90940784
39MP0003329_amyloid_beta_deposits0.90162722
40MP0001502_abnormal_circadian_rhythm0.88593857
41MP0005334_abnormal_fat_pad0.88143561
42MP0009384_cardiac_valve_regurgitation0.86632517
43MP0005360_urolithiasis0.85665129
44MP0009053_abnormal_anal_canal0.84270978
45MP0000470_abnormal_stomach_morphology0.83802113
46MP0002161_abnormal_fertility/fecundity0.81218364
47MP0002970_abnormal_white_adipose0.78936455
48MP0003646_muscle_fatigue0.78920552
49MP0001963_abnormal_hearing_physiology0.78771020
50MP0005310_abnormal_salivary_gland0.78518594
51MP0003953_abnormal_hormone_level0.77024615
52MP0001944_abnormal_pancreas_morphology0.71404341
53MP0005332_abnormal_amino_acid0.71389354
54MP0002078_abnormal_glucose_homeostasis0.67241754
55MP0009840_abnormal_foam_cell0.66746596
56MP0005379_endocrine/exocrine_gland_phen0.66587519
57MP0008961_abnormal_basal_metabolism0.65576493
58MP0001873_stomach_inflammation0.65307263
59MP0003195_calcinosis0.64889889
60MP0004043_abnormal_pH_regulation0.61937206
61MP0010386_abnormal_urinary_bladder0.60015806
62MP0001486_abnormal_startle_reflex0.57493846
63MP0005646_abnormal_pituitary_gland0.56846123
64MP0004019_abnormal_vitamin_homeostasis0.56600539
65MP0002127_abnormal_cardiovascular_syste0.55305920
66MP0001145_abnormal_male_reproductive0.55250695
67MP0000604_amyloidosis0.54531270
68MP0000013_abnormal_adipose_tissue0.53380691
69MP0008872_abnormal_physiological_respon0.53254251
70MP0000230_abnormal_systemic_arterial0.52936915
71MP0000026_abnormal_inner_ear0.52484944
72MP0003283_abnormal_digestive_organ0.50677363
73MP0002928_abnormal_bile_duct0.50275073
74MP0000049_abnormal_middle_ear0.50177309
75MP0005636_abnormal_mineral_homeostasis0.50163523
76MP0008995_early_reproductive_senescence0.50030995
77MP0000516_abnormal_urinary_system0.49949451
78MP0005367_renal/urinary_system_phenotyp0.49949451
79MP0003724_increased_susceptibility_to0.49772445
80MP0008770_decreased_survivor_rate0.49244303
81MP0002210_abnormal_sex_determination0.48715535
82MP0005375_adipose_tissue_phenotype0.48112846
83MP0005076_abnormal_cell_differentiation0.48041074
84MP0000003_abnormal_adipose_tissue0.47190589
85MP0003866_abnormal_defecation0.46556743
86MP0005551_abnormal_eye_electrophysiolog0.46523350
87MP0003252_abnormal_bile_duct0.46461479
88MP0002971_abnormal_brown_adipose0.46035177
89MP0003828_pulmonary_edema0.45996058
90MP0000467_abnormal_esophagus_morphology0.45501617
91MP0000653_abnormal_sex_gland0.45440892
92MP0004742_abnormal_vestibular_system0.44898678
93MP0009643_abnormal_urine_homeostasis0.44064754
94MP0003119_abnormal_digestive_system0.42998955
95MP0003045_fibrosis0.42142147
96MP0002098_abnormal_vibrissa_morphology0.40312155
97MP0004233_abnormal_muscle_weight0.39574852
98MP0005166_decreased_susceptibility_to0.39347412
99MP0009780_abnormal_chondrocyte_physiolo0.39108355
100MP0000598_abnormal_liver_morphology0.39061121

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.86437680
2Fat malabsorption (HP:0002630)7.38849502
3Hypoproteinemia (HP:0003075)7.17550763
4Exocrine pancreatic insufficiency (HP:0001738)6.49157274
5Tubulointerstitial nephritis (HP:0001970)5.55057296
6Chronic hepatic failure (HP:0100626)4.81737701
7Hypoalphalipoproteinemia (HP:0003233)4.14708965
8Insulin-resistant diabetes mellitus (HP:0000831)4.05444058
9Severe visual impairment (HP:0001141)3.76999292
10Progressive cerebellar ataxia (HP:0002073)3.75545445
11Male infertility (HP:0003251)3.66101441
12Genetic anticipation (HP:0003743)3.65636837
13Facial shape deformation (HP:0011334)3.62823280
14Potter facies (HP:0002009)3.62823280
15Congenital sensorineural hearing impairment (HP:0008527)3.56049434
16Increased purine levels (HP:0004368)3.55859085
17Hyperuricemia (HP:0002149)3.55859085
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.54551827
19Absent/shortened dynein arms (HP:0200106)3.54551827
20Asymmetric septal hypertrophy (HP:0001670)3.53633056
21Attenuation of retinal blood vessels (HP:0007843)3.48007051
22Pigmentary retinal degeneration (HP:0001146)3.34245476
23Abnormality of the nasal septum (HP:0000419)3.27389017
24Cone-rod dystrophy (HP:0000548)3.25395187
25Hyperkalemia (HP:0002153)3.23926517
26Decreased circulating renin level (HP:0003351)3.22782822
27Abnormal pancreas size (HP:0012094)3.13737519
28Pancreatitis (HP:0001733)2.98282574
29Renovascular hypertension (HP:0100817)2.95086916
30Tubulointerstitial abnormality (HP:0001969)2.91181846
31Abnormality of the costochondral junction (HP:0000919)2.82601391
32Tubular atrophy (HP:0000092)2.73042279
33Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.64872156
34Short 1st metacarpal (HP:0010034)2.64872156
35Abnormality of the 1st metacarpal (HP:0010009)2.62557205
36Insulin resistance (HP:0000855)2.62480329
37Abnormality of potassium homeostasis (HP:0011042)2.57524996
38Portal hypertension (HP:0001409)2.56763905
39Abnormality of purine metabolism (HP:0004352)2.56388768
40Abnormal ciliary motility (HP:0012262)2.50979624
41Bony spicule pigmentary retinopathy (HP:0007737)2.48482250
42Amelogenesis imperfecta (HP:0000705)2.45408488
43Progressive sensorineural hearing impairment (HP:0000408)2.43797597
44Subcapsular cataract (HP:0000523)2.41756398
45Nasal polyposis (HP:0100582)2.41105066
46Infertility (HP:0000789)2.39810823
47Short phalanx of the thumb (HP:0009660)2.39024701
48Anal stenosis (HP:0002025)2.36775241
49Abnormality of chloride homeostasis (HP:0011422)2.34451483
50Abnormality of dental color (HP:0011073)2.34449697
51Abnormality of the hepatic vasculature (HP:0006707)2.32849863
52Menstrual irregularities (HP:0000858)2.32233049
53Abnormal respiratory motile cilium physiology (HP:0012261)2.31120029
54Abnormality of renin-angiotensin system (HP:0000847)2.30033960
55Hypolipoproteinemia (HP:0010981)2.29838764
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24018096
57Unilateral renal agenesis (HP:0000122)2.23509081
58Hypoalbuminemia (HP:0003073)2.21973659
59Abnormal albumin level (HP:0012116)2.21973659
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20122559
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18739479
62Abnormality of the pleura (HP:0002103)2.17420862
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.17169942
64Abnormal respiratory motile cilium morphology (HP:0005938)2.14783510
65Abnormal respiratory epithelium morphology (HP:0012253)2.14783510
66Abnormality of nucleobase metabolism (HP:0010932)2.14001867
67Focal segmental glomerulosclerosis (HP:0000097)2.13369952
68Stage 5 chronic kidney disease (HP:0003774)2.10463702
69Glycosuria (HP:0003076)2.08858634
70Abnormality of urine glucose concentration (HP:0011016)2.08858634
71Hypoplasia of the thymus (HP:0000778)2.07992813
72Hyperactive renin-angiotensin system (HP:0000841)2.06000635
73Acanthosis nigricans (HP:0000956)2.05974511
74Hypokalemia (HP:0002900)2.03459052
75Abnormality of the nasal mucosa (HP:0000433)2.01247067
76Recurrent pneumonia (HP:0006532)2.00981930
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99577464
78Maternal diabetes (HP:0009800)1.98866303
79Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98030623
80Ileus (HP:0002595)1.96838510
81Abnormality of the aortic arch (HP:0012303)1.96514127
82Flattened epiphyses (HP:0003071)1.94379152
83Metabolic alkalosis (HP:0200114)1.92595455
84Impulsivity (HP:0100710)1.91846221
85Hypoplastic ischia (HP:0003175)1.91717068
86Popliteal pterygium (HP:0009756)1.91629439
87Enlarged epiphyses (HP:0010580)1.89769130
88Nephritis (HP:0000123)1.88757680
89Widely patent fontanelles and sutures (HP:0004492)1.87611501
90Urethral obstruction (HP:0000796)1.87607787
91Malnutrition (HP:0004395)1.85804506
92Abnormal spermatogenesis (HP:0008669)1.84483633
93Decreased central vision (HP:0007663)1.83683467
94Abnormality of the renal medulla (HP:0100957)1.80375918
95Azoospermia (HP:0000027)1.80184843
96Postural instability (HP:0002172)1.77662149
97Preauricular pit (HP:0004467)1.76903772
98Periauricular skin pits (HP:0100277)1.76903772
99Carpal bone hypoplasia (HP:0001498)1.75419844
100Abnormality of the ischium (HP:0003174)1.75044608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.65124180
2PLK45.28054326
3TESK13.74303481
4ERN13.21166145
5EPHA23.06516328
6LMTK22.99662181
7BRD42.83066294
8NME12.69074685
9TAOK32.63284033
10DDR22.41802521
11MST1R2.40580657
12MAPK152.07330240
13MAP3K22.04540329
14MAP3K31.96698892
15STK381.90729596
16WNK41.89181555
17PLK21.79939268
18RIPK11.79797832
19PIK3CG1.76621973
20STK391.72488892
21CAMK1G1.69800631
22PRKG21.62463962
23MAP4K21.50509795
24EIF2AK31.41300615
25PDPK11.40904324
26NTRK31.38792391
27PDK11.35356383
28PASK1.33528732
29NEK61.28092101
30AKT31.24571486
31GRK11.18936948
32MAP3K111.17367672
33MAP3K71.15344551
34PNCK1.14569295
35PRKD31.12185618
36PRKAA21.11036290
37ACVR1B1.10796100
38CDK121.08152224
39CDK91.02358586
40DYRK1B1.01855496
41MAPKAPK31.01466688
42CAMK1D0.98922562
43ADRBK20.98409629
44WNK10.91906445
45MAP2K10.79055469
46TYRO30.78957424
47MAP2K20.78229339
48SGK2230.75273780
49SGK4940.75273780
50SGK30.74900851
51NLK0.70099883
52MELK0.68517674
53SGK20.68349210
54TXK0.65633232
55MET0.64213847
56MUSK0.63390803
57STK38L0.62507437
58RPS6KA20.62116393
59TESK20.61927089
60MAPK110.61707596
61CAMKK10.56473315
62OXSR10.56298736
63SCYL20.56068239
64PIK3CA0.55381628
65TAOK20.54072465
66MAPK10.52087782
67EEF2K0.50711817
68MAP3K120.49850631
69CAMK40.48726208
70PRPF4B0.46802451
71BRSK20.45219304
72PDK20.42990790
73TNIK0.41229473
74PRKG10.40350823
75PRKAA10.39736956
76MAP3K10.39198185
77MAPK80.36916570
78ROCK10.36659466
79CHUK0.36135152
80MTOR0.35806401
81PRKCZ0.34707045
82GSK3B0.33526075
83DAPK20.32505149
84STK110.31717076
85SGK10.31645436
86IRAK10.31207855
87MAPKAPK50.29984276
88MAPK30.28770151
89MAP3K50.26962037
90MAP2K60.24184738
91RPS6KA10.24119824
92ADRBK10.23849353
93FRK0.23478258
94RPS6KA60.23056894
95MAPK140.22559956
96PRKACA0.21757321
97PRKCA0.21244645
98ERBB20.18623672
99IKBKB0.18581027
100CDK40.17832097

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049728.68815323
2Fat digestion and absorption_Homo sapiens_hsa049758.08166606
3Protein digestion and absorption_Homo sapiens_hsa049746.04354407
4Renin-angiotensin system_Homo sapiens_hsa046143.74602180
5Glycerolipid metabolism_Homo sapiens_hsa005613.03781531
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.53805581
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52697400
8Linoleic acid metabolism_Homo sapiens_hsa005912.19894753
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88618210
10Starch and sucrose metabolism_Homo sapiens_hsa005001.65934828
11Vitamin digestion and absorption_Homo sapiens_hsa049771.61769564
12Notch signaling pathway_Homo sapiens_hsa043301.55236357
13Fatty acid biosynthesis_Homo sapiens_hsa000611.46200439
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39897360
15Circadian rhythm_Homo sapiens_hsa047101.24653863
16Ether lipid metabolism_Homo sapiens_hsa005651.24331241
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18953459
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02405704
19Glycerophospholipid metabolism_Homo sapiens_hsa005640.93886491
20Steroid biosynthesis_Homo sapiens_hsa001000.90929898
21Arachidonic acid metabolism_Homo sapiens_hsa005900.83006337
22Phototransduction_Homo sapiens_hsa047440.82745682
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81358164
24Influenza A_Homo sapiens_hsa051640.74128021
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69694757
26Bile secretion_Homo sapiens_hsa049760.68314750
27Mineral absorption_Homo sapiens_hsa049780.66759778
28Olfactory transduction_Homo sapiens_hsa047400.59635034
29Arginine biosynthesis_Homo sapiens_hsa002200.57632362
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53992060
31Butanoate metabolism_Homo sapiens_hsa006500.53627838
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52374265
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.50346909
34Nitrogen metabolism_Homo sapiens_hsa009100.49179232
35PPAR signaling pathway_Homo sapiens_hsa033200.47005987
36Vascular smooth muscle contraction_Homo sapiens_hsa042700.45405118
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44411897
38Fatty acid degradation_Homo sapiens_hsa000710.42247987
39Retinol metabolism_Homo sapiens_hsa008300.41502691
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.41051703
41ABC transporters_Homo sapiens_hsa020100.40236037
42Chemical carcinogenesis_Homo sapiens_hsa052040.39727205
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37902525
44Arginine and proline metabolism_Homo sapiens_hsa003300.37772067
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36721085
46Insulin secretion_Homo sapiens_hsa049110.35959435
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.34205109
48Histidine metabolism_Homo sapiens_hsa003400.32979415
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29719253
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28411994
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28326482
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.25517384
53Sulfur metabolism_Homo sapiens_hsa009200.24860471
54Type I diabetes mellitus_Homo sapiens_hsa049400.24679529
55Salivary secretion_Homo sapiens_hsa049700.22175555
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21933481
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21269325
58Antigen processing and presentation_Homo sapiens_hsa046120.21245221
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20631445
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16482940
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16482115
62Taste transduction_Homo sapiens_hsa047420.16190228
63Selenocompound metabolism_Homo sapiens_hsa004500.16074394
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15708524
65Thyroid cancer_Homo sapiens_hsa052160.14527663
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14453960
67Calcium signaling pathway_Homo sapiens_hsa040200.14396505
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.13912386
69Gastric acid secretion_Homo sapiens_hsa049710.12609025
70Caffeine metabolism_Homo sapiens_hsa002320.11907728
71Tryptophan metabolism_Homo sapiens_hsa003800.11063977
72Fatty acid metabolism_Homo sapiens_hsa012120.10541496
73Tight junction_Homo sapiens_hsa045300.10217353
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09494583
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.08743231
76Graft-versus-host disease_Homo sapiens_hsa053320.08589129
77Allograft rejection_Homo sapiens_hsa053300.08175438
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08130118
79Type II diabetes mellitus_Homo sapiens_hsa049300.08126894
80Autoimmune thyroid disease_Homo sapiens_hsa053200.07457889
81Vitamin B6 metabolism_Homo sapiens_hsa007500.07008310
82Nicotine addiction_Homo sapiens_hsa050330.06956994
83Metabolic pathways_Homo sapiens_hsa011000.06656178
84Dorso-ventral axis formation_Homo sapiens_hsa043200.06284289
85Renin secretion_Homo sapiens_hsa049240.05960967
86Galactose metabolism_Homo sapiens_hsa000520.05825189
87Estrogen signaling pathway_Homo sapiens_hsa049150.05131115
88cAMP signaling pathway_Homo sapiens_hsa040240.05042558
89Circadian entrainment_Homo sapiens_hsa047130.04518330
90Amphetamine addiction_Homo sapiens_hsa050310.03550245
91Viral carcinogenesis_Homo sapiens_hsa052030.03209584
92Adherens junction_Homo sapiens_hsa045200.02775146
93Sulfur relay system_Homo sapiens_hsa041220.02062950
94Epstein-Barr virus infection_Homo sapiens_hsa051690.01680218
95Insulin resistance_Homo sapiens_hsa049310.00854634
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00496547
97Inositol phosphate metabolism_Homo sapiens_hsa005620.00082230
98MAPK signaling pathway_Homo sapiens_hsa04010-0.0150944
99Endocytosis_Homo sapiens_hsa04144-0.0150607
100Cocaine addiction_Homo sapiens_hsa05030-0.0064544

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