AQP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to parathyroid hormone (GO:0071107)9.77905925
2renal absorption (GO:0070293)8.98694206
3* excretion (GO:0007588)8.91400896
4lysine metabolic process (GO:0006553)8.66794991
5lysine catabolic process (GO:0006554)8.66794991
6drug transmembrane transport (GO:0006855)8.07392751
7aminoglycoside antibiotic metabolic process (GO:0030647)8.04861752
8urate metabolic process (GO:0046415)7.94204788
9metanephric nephron tubule development (GO:0072234)7.80037244
10metanephric tubule development (GO:0072170)7.80037244
11response to lead ion (GO:0010288)7.28791499
12organic cation transport (GO:0015695)7.28219240
13metanephric nephron epithelium development (GO:0072243)7.15523892
14positive regulation of catenin import into nucleus (GO:0035413)7.08627457
15drug transport (GO:0015893)6.99452285
16activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.87478838
17positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)6.76838976
18positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.73674584
19phosphate ion transport (GO:0006817)6.63982967
20metanephric epithelium development (GO:0072207)6.57977830
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.28967556
22regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.22476435
23negative regulation of sterol transport (GO:0032372)6.18771341
24negative regulation of cholesterol transport (GO:0032375)6.18771341
25negative regulation of metanephros development (GO:0072217)6.10409291
26response to thyroid hormone (GO:0097066)6.05537864
27nephron tubule formation (GO:0072079)5.99673472
28aspartate family amino acid catabolic process (GO:0009068)5.98636059
29glyoxylate metabolic process (GO:0046487)5.93100483
30quaternary ammonium group transport (GO:0015697)5.84860459
31regulation of apoptotic process involved in morphogenesis (GO:1902337)5.80706231
32cysteine metabolic process (GO:0006534)5.75347134
33sodium-independent organic anion transport (GO:0043252)5.70704920
34one-carbon compound transport (GO:0019755)5.66588398
35response to magnesium ion (GO:0032026)5.65186131
36tricarboxylic acid metabolic process (GO:0072350)5.63892552
37nephron tubule development (GO:0072080)5.60906032
38regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.59325150
39phosphate ion transmembrane transport (GO:0035435)5.51812866
40* response to mercury ion (GO:0046689)5.45855885
412-oxoglutarate metabolic process (GO:0006103)5.41238680
42inositol metabolic process (GO:0006020)5.26711771
43branched-chain amino acid metabolic process (GO:0009081)5.09717408
44short-chain fatty acid metabolic process (GO:0046459)5.06322351
45valine metabolic process (GO:0006573)5.04800176
46negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.03562468
47renal tubule development (GO:0061326)4.97965658
48response to vitamin A (GO:0033189)4.92271388
49pattern specification involved in kidney development (GO:0061004)4.90728174
50bone remodeling (GO:0046849)4.85414632
51cellular response to ammonium ion (GO:0071242)4.82954165
52nonribosomal peptide biosynthetic process (GO:0019184)4.80327178
53regulation of protein localization to cell surface (GO:2000008)4.71432904
54vitamin D metabolic process (GO:0042359)4.69998416
55* polyol transport (GO:0015791)4.69702591
56homocysteine metabolic process (GO:0050667)4.68841842
57indole-containing compound catabolic process (GO:0042436)4.67929744
58indolalkylamine catabolic process (GO:0046218)4.67929744
59tryptophan catabolic process (GO:0006569)4.67929744
60amino-acid betaine transport (GO:0015838)4.65852417
61carnitine transport (GO:0015879)4.65852417
62aromatic amino acid family catabolic process (GO:0009074)4.60839093
63nephron epithelium development (GO:0072009)4.59464901
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55140737
65L-phenylalanine metabolic process (GO:0006558)4.55140737
66mammary gland alveolus development (GO:0060749)4.52483664
67branched-chain amino acid catabolic process (GO:0009083)4.46020355
68tryptophan metabolic process (GO:0006568)4.38677750
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.35422627
70L-phenylalanine catabolic process (GO:0006559)4.35422627
71kynurenine metabolic process (GO:0070189)4.35327024
72ERK1 and ERK2 cascade (GO:0070371)4.32740356
73cellular ketone body metabolic process (GO:0046950)4.31427336
74positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.29484258
75glutathione biosynthetic process (GO:0006750)4.29312145
76cellular modified amino acid catabolic process (GO:0042219)4.27882652
77fatty acid beta-oxidation (GO:0006635)4.25774717
78regulation of fever generation (GO:0031620)4.22170820
79amino-acid betaine metabolic process (GO:0006577)4.21518811
80glomerular visceral epithelial cell development (GO:0072015)4.20782766
81NADH metabolic process (GO:0006734)4.17994502
82modified amino acid transport (GO:0072337)4.16168074
83phosphate ion homeostasis (GO:0055062)4.13439780
84trivalent inorganic anion homeostasis (GO:0072506)4.13439780
85toxin transport (GO:1901998)4.12944138
86positive regulation of heat generation (GO:0031652)4.11983739
87glutamate metabolic process (GO:0006536)4.11808895
88acetyl-CoA metabolic process (GO:0006084)4.10262135
89proline metabolic process (GO:0006560)4.08086491
90carnitine metabolic process (GO:0009437)4.01583916
91drug catabolic process (GO:0042737)4.00643789
92urogenital system development (GO:0001655)4.00441877
93fatty acid oxidation (GO:0019395)3.98750295
94cell differentiation involved in metanephros development (GO:0072202)3.96771206
95tricarboxylic acid cycle (GO:0006099)3.96752072
96fructose metabolic process (GO:0006000)3.95277813
97serine family amino acid catabolic process (GO:0009071)3.93846969
98regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.92871982
99lipid oxidation (GO:0034440)3.91529986
100regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.84304091
101regulation of mesenchymal cell apoptotic process (GO:2001053)3.84179581
102regulation of potassium ion transmembrane transporter activity (GO:1901016)3.83302880
103mesonephros development (GO:0001823)3.81923401
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.78188550
105beta-amyloid metabolic process (GO:0050435)3.77868663
106nephron tubule morphogenesis (GO:0072078)3.74346481
107nephron epithelium morphogenesis (GO:0072088)3.74346481
108amino acid salvage (GO:0043102)3.74159571
109L-methionine salvage (GO:0071267)3.74159571
110L-methionine biosynthetic process (GO:0071265)3.74159571
111cardiovascular system development (GO:0072358)3.72854355
112serine family amino acid metabolic process (GO:0009069)3.72139425
113regulation of cholesterol efflux (GO:0010874)3.72098653
114S-adenosylmethionine metabolic process (GO:0046500)3.70266956
115glomerular epithelial cell development (GO:0072310)3.69867899
116ketone body metabolic process (GO:1902224)3.69801855
117positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.63444729
118transepithelial transport (GO:0070633)3.62009117
119oxaloacetate metabolic process (GO:0006107)3.59781195
120exogenous drug catabolic process (GO:0042738)3.59361471
121regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.57330634
122glycoside metabolic process (GO:0016137)3.55582297
123response to phenylpropanoid (GO:0080184)3.53588747
124fatty acid catabolic process (GO:0009062)3.52233666
125hyperosmotic salinity response (GO:0042538)3.50980667
126regulation of catenin import into nucleus (GO:0035412)3.50137162
127cellular amino acid catabolic process (GO:0009063)3.50057534
128sodium ion transport (GO:0006814)3.48909983
129peptide biosynthetic process (GO:0043043)3.44866300
130positive regulation of ERBB signaling pathway (GO:1901186)3.42992245
131regulation of stem cell maintenance (GO:2000036)3.42284769
132regulation of anion transport (GO:0044070)3.41163424
133biotin metabolic process (GO:0006768)3.40681142
134negative regulation of kidney development (GO:0090185)3.40022681
135alpha-amino acid catabolic process (GO:1901606)3.39212863
136aromatic amino acid family metabolic process (GO:0009072)3.39053884
137succinate metabolic process (GO:0006105)3.37946853
138sulfur amino acid catabolic process (GO:0000098)3.35397119
139regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.33559882
140vitamin transport (GO:0051180)3.33167459
141regulation of heat generation (GO:0031650)3.32418012
142positive regulation of digestive system process (GO:0060456)3.31615114
143inorganic anion transport (GO:0015698)3.28280944
144indole-containing compound metabolic process (GO:0042430)3.27611787
145kidney epithelium development (GO:0072073)3.27495824
146monocarboxylic acid catabolic process (GO:0072329)3.26746250
147* renal system process (GO:0003014)3.25824766
148sodium ion export (GO:0071436)3.21885588
149indolalkylamine metabolic process (GO:0006586)3.21878451
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.21873459
151organic acid catabolic process (GO:0016054)3.21706103
152carboxylic acid catabolic process (GO:0046395)3.21706103
153positive regulation of metanephros development (GO:0072216)3.21561244
154response to growth hormone (GO:0060416)3.20927412
155chloride transmembrane transport (GO:1902476)3.20860949
156glutathione derivative biosynthetic process (GO:1901687)3.20147995
157glutathione derivative metabolic process (GO:1901685)3.20147995
158mesenchymal to epithelial transition (GO:0060231)3.19456259
159peptide catabolic process (GO:0043171)3.17692149
160regulation of potassium ion transmembrane transport (GO:1901379)3.08949174
161inorganic anion transmembrane transport (GO:0098661)3.08875920
162regulation of calcium ion import (GO:0090279)3.07790261
163glycine metabolic process (GO:0006544)3.05745363
164negative regulation of lipid transport (GO:0032369)3.04945924
165sodium ion homeostasis (GO:0055078)3.03721849
166positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.03298135
167metanephric mesenchyme development (GO:0072075)3.01505607
168specification of organ identity (GO:0010092)3.01091631
169kidney development (GO:0001822)2.96972323
170chloride transport (GO:0006821)2.96882099
171mesenchymal cell differentiation involved in kidney development (GO:0072161)2.91503360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.65585806
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84078428
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.59193970
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.75073696
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.46409340
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.28517963
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.95256394
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.93294634
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89445685
10CLOCK_20551151_ChIP-Seq_293T_Human2.74711202
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.59312153
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56616262
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.50736169
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.49524816
15VDR_22108803_ChIP-Seq_LS180_Human2.41369452
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34535667
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17502237
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04758317
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92716473
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89158079
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85904043
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85030453
23P53_22127205_ChIP-Seq_FIBROBLAST_Human1.81420806
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80981088
25KLF4_18555785_Chip-Seq_ESCs_Mouse1.80867345
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.73103997
27AR_21909140_ChIP-Seq_LNCAP_Human1.72577925
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68366818
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.67227052
30GATA4_25053715_ChIP-Seq_YYC3_Human1.61836845
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.61497574
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59728595
33LXR_22292898_ChIP-Seq_THP-1_Human1.59194601
34DROSHA_22980978_ChIP-Seq_HELA_Human1.55271559
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.53417659
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.51808036
37RACK7_27058665_Chip-Seq_MCF-7_Human1.51328816
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50375584
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.50202593
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46883758
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45581495
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.39059289
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.38623709
44AHR_22903824_ChIP-Seq_MCF-7_Human1.38033755
45CBP_21632823_ChIP-Seq_H3396_Human1.37131320
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32889556
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31706255
48EGR1_19032775_ChIP-ChIP_M12_Human1.30416006
49RXR_22108803_ChIP-Seq_LS180_Human1.29065774
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29005470
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.28008108
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.26274783
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.25891967
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.25791597
55ZFX_18555785_Chip-Seq_ESCs_Mouse1.25779366
56SMAD3_21741376_ChIP-Seq_HESCs_Human1.25457982
57GBX2_23144817_ChIP-Seq_PC3_Human1.24198828
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23930887
59GATA6_25053715_ChIP-Seq_YYC3_Human1.23821698
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23694023
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23681696
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.23599232
63P300_18555785_Chip-Seq_ESCs_Mouse1.23406104
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.23279156
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.23279156
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22560334
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21744303
68CDX2_22108803_ChIP-Seq_LS180_Human1.20401218
69TCF4_22108803_ChIP-Seq_LS180_Human1.20049134
70* SMAD4_21799915_ChIP-Seq_A2780_Human1.19533310
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19396843
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.19294328
73P53_22387025_ChIP-Seq_ESCs_Mouse1.19227983
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19158056
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19158056
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.18847701
77SOX2_20726797_ChIP-Seq_SW620_Human1.18290683
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17190989
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16881538
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16134173
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15949922
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15920875
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15357017
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15131991
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13852407
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13672518
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12956312
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12950823
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12369728
90TBL1_22424771_ChIP-Seq_293T_Human1.12061443
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10686376
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10338094
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10222847
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10048216
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10026893
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09294374
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08891511
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08538182
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08491335
100KDM2B_26808549_Chip-Seq_REH_Human1.08296968
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.08051355
102PHF8_20622853_ChIP-Seq_HELA_Human1.07956425
103* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07299972
104GATA1_22025678_ChIP-Seq_K562_Human1.07020829
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06454286
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06410265
107ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06381197
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05590717
109PU1_27457419_Chip-Seq_LIVER_Mouse1.05526812
110VDR_24787735_ChIP-Seq_THP-1_Human1.05464619
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05256337
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.04758959
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03413971
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02687360
115NFYA_21822215_ChIP-Seq_K562_Human1.01802630
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01343758
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01324540
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01193372
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01003805
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.00795090
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99357563
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99256929
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99132908
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98809899
125HTT_18923047_ChIP-ChIP_STHdh_Human0.96903703
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96816949
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95204374
128CTCF_27219007_Chip-Seq_Bcells_Human0.93150916
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92337123
130* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91748952
131CREB1_26743006_Chip-Seq_LNCaP_Human0.90653684
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90551240
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90542264
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88521046
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88295499
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.88076795
137ATF3_27146783_Chip-Seq_COLON_Human0.86204450
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86138754
139GATA2_19941826_ChIP-Seq_K562_Human0.85825283
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85445555
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84513075
142RAC3_21632823_ChIP-Seq_H3396_Human0.84202757
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82250869
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81274242
145P68_20966046_ChIP-Seq_HELA_Human0.81137375
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80960453
147SMC4_20622854_ChIP-Seq_HELA_Human0.80910633
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80876483
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.80816886
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80807895
151TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80505542
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80442331
153GATA1_19941826_ChIP-Seq_K562_Human0.77766737
154TP63_23658742_ChIP-Seq_EP156T_Human0.77589121
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77589057
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76869706
157FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75817390
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75392335
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74766327
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74089154
161CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74052382
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74050589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation9.20174124
2MP0003195_calcinosis7.14055226
3MP0005360_urolithiasis6.10658873
4* MP0001756_abnormal_urination4.62099959
5MP0005332_abnormal_amino_acid4.46594035
6MP0001765_abnormal_ion_homeostasis4.04098438
7* MP0009643_abnormal_urine_homeostasis3.96725714
8MP0004019_abnormal_vitamin_homeostasis3.80923910
9MP0002139_abnormal_hepatobiliary_system3.45342945
10MP0005636_abnormal_mineral_homeostasis3.19195439
11MP0002138_abnormal_hepatobiliary_system3.19130953
12* MP0002136_abnormal_kidney_physiology3.06514329
13MP0004885_abnormal_endolymph2.43985146
14MP0003878_abnormal_ear_physiology2.19366202
15MP0005377_hearing/vestibular/ear_phenot2.19366202
16MP0008961_abnormal_basal_metabolism2.18166059
17MP0003252_abnormal_bile_duct2.14876901
18MP0008875_abnormal_xenobiotic_pharmacok2.06151982
19MP0001958_emphysema1.96763543
20MP0005365_abnormal_bile_salt1.70039218
21MP0005085_abnormal_gallbladder_physiolo1.63697344
22MP0002168_other_aberrant_phenotype1.62392908
23MP0005058_abnormal_lysosome_morphology1.59685943
24MP0005451_abnormal_body_composition1.56599531
25MP0005584_abnormal_enzyme/coenzyme_acti1.49826113
26MP0000230_abnormal_systemic_arterial1.38970122
27MP0010234_abnormal_vibrissa_follicle1.35609394
28MP0003283_abnormal_digestive_organ1.28875935
29MP0003186_abnormal_redox_activity1.26148846
30MP0003300_gastrointestinal_ulcer1.20854072
31MP0005319_abnormal_enzyme/_coenzyme1.15328025
32MP0003045_fibrosis1.14216381
33* MP0002135_abnormal_kidney_morphology1.13770804
34MP0006036_abnormal_mitochondrial_physio1.13119182
35MP0002928_abnormal_bile_duct1.06606654
36MP0005535_abnormal_body_temperature1.06592142
37MP0001764_abnormal_homeostasis1.00353923
38MP0003191_abnormal_cellular_cholesterol0.99404385
39MP0002876_abnormal_thyroid_physiology0.98661067
40MP0003806_abnormal_nucleotide_metabolis0.93225548
41MP0005084_abnormal_gallbladder_morpholo0.89405090
42MP0005666_abnormal_adipose_tissue0.88726489
43MP0009672_abnormal_birth_weight0.87479238
44MP0005395_other_phenotype0.84654506
45MP0003959_abnormal_lean_body0.81345498
46MP0003646_muscle_fatigue0.79956922
47MP0008004_abnormal_stomach_pH0.77616376
48MP0004742_abnormal_vestibular_system0.77048772
49MP0005670_abnormal_white_adipose0.75959383
50MP0003638_abnormal_response/metabolism_0.74918442
51MP0002896_abnormal_bone_mineralization0.74087616
52* MP0000538_abnormal_urinary_bladder0.73038794
53MP0002118_abnormal_lipid_homeostasis0.71038987
54MP0001666_abnormal_nutrient_absorption0.70719179
55MP0003183_abnormal_peptide_metabolism0.69208985
56* MP0009642_abnormal_blood_homeostasis0.65985139
57* MP0001270_distended_abdomen0.65942825
58MP0004264_abnormal_extraembryonic_tissu0.63945124
59MP0002796_impaired_skin_barrier0.63923870
60MP0002089_abnormal_postnatal_growth/wei0.62240068
61MP0005220_abnormal_exocrine_pancreas0.61499312
62MP0004272_abnormal_basement_membrane0.60604672
63MP0010386_abnormal_urinary_bladder0.60288891
64MP0003943_abnormal_hepatobiliary_system0.59123497
65MP0003315_abnormal_perineum_morphology0.56958239
66MP0005165_increased_susceptibility_to0.55457601
67MP0001661_extended_life_span0.55068679
68MP0003938_abnormal_ear_development0.54183536
69MP0009764_decreased_sensitivity_to0.52776047
70MP0003329_amyloid_beta_deposits0.51241877
71MP0004147_increased_porphyrin_level0.49590739
72MP0000747_muscle_weakness0.49375690
73MP0003075_altered_response_to0.47899290
74* MP0002069_abnormal_eating/drinking_beha0.47481570
75MP0002971_abnormal_brown_adipose0.47209892
76MP0000609_abnormal_liver_physiology0.46975964
77MP0002078_abnormal_glucose_homeostasis0.46973871
78MP0002234_abnormal_pharynx_morphology0.46565900
79MP0004858_abnormal_nervous_system0.46248466
80MP0003795_abnormal_bone_structure0.45840912
81MP0010329_abnormal_lipoprotein_level0.45763487
82MP0000751_myopathy0.44682018
83MP0001485_abnormal_pinna_reflex0.41823919
84MP0008469_abnormal_protein_level0.40898889
85MP0005375_adipose_tissue_phenotype0.39739311
86MP0009703_decreased_birth_body0.38790130
87MP0005501_abnormal_skin_physiology0.38532126
88MP0003953_abnormal_hormone_level0.37991356
89MP0010368_abnormal_lymphatic_system0.37880761
90MP0004233_abnormal_muscle_weight0.37573596
91MP0003221_abnormal_cardiomyocyte_apopto0.37286175
92MP0004484_altered_response_of0.36386310
93MP0000026_abnormal_inner_ear0.34846085
94MP0001177_atelectasis0.34838321
95MP0003879_abnormal_hair_cell0.34741672
96MP0003172_abnormal_lysosome_physiology0.34686863
97MP0001944_abnormal_pancreas_morphology0.34543210
98MP0002972_abnormal_cardiac_muscle0.34412914
99MP0002098_abnormal_vibrissa_morphology0.33746917
100MP0006035_abnormal_mitochondrial_morpho0.32996292
101MP0000631_abnormal_neuroendocrine_gland0.32350525
102MP0003011_delayed_dark_adaptation0.32254597
103MP0005167_abnormal_blood-brain_barrier0.31847516
104MP0001963_abnormal_hearing_physiology0.31755387
105MP0000598_abnormal_liver_morphology0.31667122
106MP0002998_abnormal_bone_remodeling0.31082028
107MP0001191_abnormal_skin_condition0.30756671
108MP0001664_abnormal_digestion0.30606793
109MP0002115_abnormal_skeleton_extremities0.30562245
110MP0003941_abnormal_skin_development0.30387893
111MP0008872_abnormal_physiological_respon0.30283379
112MP0002108_abnormal_muscle_morphology0.29475925
113MP0008775_abnormal_heart_ventricle0.29151961
114MP0005330_cardiomyopathy0.28698519
115MP0001727_abnormal_embryo_implantation0.28410007
116MP0000371_diluted_coat_color0.27991819
117* MP0001731_abnormal_postnatal_growth0.27742352
118MP0004215_abnormal_myocardial_fiber0.25546262
119MP0000013_abnormal_adipose_tissue0.24086610
120MP0000163_abnormal_cartilage_morphology0.21157068
121MP0000681_abnormal_thyroid_gland0.20650257
122MP0000566_synostosis0.18568410
123* MP0000534_abnormal_ureter_morphology0.18233965
124MP0003942_abnormal_urinary_system0.16974120
125MP0005452_abnormal_adipose_tissue0.15934872
126MP0008874_decreased_physiological_sensi0.15304620
127* MP0002082_postnatal_lethality0.14260758
128* MP0010770_preweaning_lethality0.14260758
129MP0003137_abnormal_impulse_conducting0.13020761
130MP0000762_abnormal_tongue_morphology0.12997670
131* MP0010769_abnormal_survival0.10111106
132MP0005409_darkened_coat_color0.09364067
133MP0009780_abnormal_chondrocyte_physiolo0.09237741
134* MP0010768_mortality/aging0.08375874
135MP0000049_abnormal_middle_ear0.08307645
136MP0002638_abnormal_pupillary_reflex0.08265590
137MP0002113_abnormal_skeleton_development0.07927963

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)9.19578591
2Abnormality of chloride homeostasis (HP:0011422)8.86191495
3Hyperactive renin-angiotensin system (HP:0000841)8.82455699
4Hypomagnesemia (HP:0002917)8.48878792
5* Polyuria (HP:0000103)7.75827388
6Renal salt wasting (HP:0000127)7.43162919
7Hyperaldosteronism (HP:0000859)7.30896102
8Abnormality of magnesium homeostasis (HP:0004921)7.23105760
9* Abnormal urine output (HP:0012590)7.19429651
10* Abnormality of renal excretion (HP:0011036)6.44397841
11Tetany (HP:0001281)6.37102233
12Alkalosis (HP:0001948)6.25878673
13Abnormality of renin-angiotensin system (HP:0000847)5.79181824
14Gout (HP:0001997)5.72696421
15* Polydipsia (HP:0001959)5.15680063
16* Abnormal drinking behavior (HP:0030082)5.15680063
17Hypokalemia (HP:0002900)5.06940549
18Increased purine levels (HP:0004368)4.29924946
19Hyperuricemia (HP:0002149)4.29924946
20Abnormality of potassium homeostasis (HP:0011042)4.05633023
21Hypercalciuria (HP:0002150)3.91290251
22Abnormality of fatty-acid metabolism (HP:0004359)3.59128436
23Hyponatremia (HP:0002902)3.57177422
24Adrenal overactivity (HP:0002717)3.56190776
25Hyperglycinuria (HP:0003108)3.55165404
26Proximal tubulopathy (HP:0000114)3.53342746
27Abnormality of purine metabolism (HP:0004352)3.38666317
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23974773
29* Abnormality of sodium homeostasis (HP:0010931)3.04984140
30Abnormality of serine family amino acid metabolism (HP:0010894)2.86806005
31Abnormality of glycine metabolism (HP:0010895)2.86806005
32Ketoacidosis (HP:0001993)2.85150150
33Renal tubular acidosis (HP:0001947)2.84317700
34Nephrocalcinosis (HP:0000121)2.83757888
35Generalized aminoaciduria (HP:0002909)2.64544645
36Chondrocalcinosis (HP:0000934)2.54403264
37Decreased circulating renin level (HP:0003351)2.52850919
38Ketosis (HP:0001946)2.42507006
39Abnormality of Sharpey fibers (HP:0100685)2.40153715
40Abnormality of nucleobase metabolism (HP:0010932)2.36755415
41* Dehydration (HP:0001944)2.32346226
42Glycosuria (HP:0003076)2.31072501
43Abnormality of urine glucose concentration (HP:0011016)2.31072501
44Hypotension (HP:0002615)2.21531950
45Abnormality of proline metabolism (HP:0010907)2.20511668
46Hydroxyprolinuria (HP:0003080)2.20511668
47Tubulointerstitial fibrosis (HP:0005576)2.18718295
48Generalized muscle weakness (HP:0003324)2.17322785
49Metabolic alkalosis (HP:0200114)11.1920234
50Hypokalemic alkalosis (HP:0001949)10.4087848
51Hyperphosphaturia (HP:0003109)1.96570042
52Tubular atrophy (HP:0000092)1.95848667
53* Vomiting (HP:0002013)1.94717151
54Large eyes (HP:0001090)1.91891992
55Nephrolithiasis (HP:0000787)1.90704501
56Facial shape deformation (HP:0011334)1.87949742
57Potter facies (HP:0002009)1.87949742
58Hyperglycinemia (HP:0002154)1.87668872
59Abnormal urine phosphate concentration (HP:0012599)1.85013798
60Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81446268
61Hyperammonemia (HP:0001987)1.79879898
62Delayed CNS myelination (HP:0002188)1.79633898
63Dicarboxylic aciduria (HP:0003215)1.76441543
64Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76441543
65Glomerulosclerosis (HP:0000096)1.73911503
66Delayed epiphyseal ossification (HP:0002663)1.71970399
67Metabolic acidosis (HP:0001942)1.67593664
68Renal tubular dysfunction (HP:0000124)1.67484633
69Hypophosphatemia (HP:0002148)1.64499021
70Enlarged kidneys (HP:0000105)1.61663008
71Impaired platelet aggregation (HP:0003540)1.59299891
72Abnormal platelet function (HP:0011869)1.59299891
73Focal segmental glomerulosclerosis (HP:0000097)1.58338827
74Vacuolated lymphocytes (HP:0001922)1.57308508
75Rickets (HP:0002748)1.53605575
76Metaphyseal cupping (HP:0003021)1.51509599
77Abnormality of aromatic amino acid family metabolism (HP:0004338)1.50074746
78Lethargy (HP:0001254)1.48623936
79Widely patent fontanelles and sutures (HP:0004492)1.45827661
80Abnormality of sulfur amino acid metabolism (HP:0004339)1.44440728
81Abnormality of the renal cortex (HP:0011035)1.43912850
82Abnormality of renal resorption (HP:0011038)1.42221833
83Confusion (HP:0001289)1.41654824
84Vascular calcification (HP:0004934)1.41636543
85Hyperkalemia (HP:0002153)1.41466581
86Bilateral sensorineural hearing impairment (HP:0008619)1.39601966
87Malnutrition (HP:0004395)1.38861057
88Lymphangioma (HP:0100764)1.37597082
89Osteopenia (HP:0000938)1.37585901
90Methylmalonic aciduria (HP:0012120)1.36884949
91Tubulointerstitial abnormality (HP:0001969)1.35734674
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.33011743
93Paresthesia (HP:0003401)1.30182044
94Bicornuate uterus (HP:0000813)1.29648849
95Hypothermia (HP:0002045)1.27936091
96Cardiovascular calcification (HP:0011915)1.26491030
97Thin bony cortex (HP:0002753)1.26152728
98Acute encephalopathy (HP:0006846)1.24585135
99Abnormal enzyme/coenzyme activity (HP:0012379)1.24414685
100Nausea (HP:0002018)1.22851649
101Abnormality of alkaline phosphatase activity (HP:0004379)1.20461763
102Premature birth (HP:0001622)1.19534204
103Tachypnea (HP:0002789)1.18464565
104Metaphyseal dysplasia (HP:0100255)1.18108231
105Abnormality of the renal medulla (HP:0100957)1.17311245
106Intellectual disability, moderate (HP:0002342)1.10173984
107Abnormality of calcium-phosphate metabolism (HP:0100530)1.09758739
108Elevated alkaline phosphatase (HP:0003155)1.09137198
109Polyhydramnios (HP:0001561)1.07276837
110Small for gestational age (HP:0001518)1.04327160
111Abnormal tarsal ossification (HP:0008369)1.00705173
112Neonatal death (HP:0003811)0.99462132
113Thyroid-stimulating hormone excess (HP:0002925)0.95857672
114Persistence of primary teeth (HP:0006335)0.94302462
115Osteomalacia (HP:0002749)0.83430105
116Abnormality of the fingertips (HP:0001211)0.78226844
117Hyperphosphatemia (HP:0002905)0.76363725
118Hypophosphatemic rickets (HP:0004912)0.75803248
119Abnormality of macular pigmentation (HP:0008002)0.75199193
120Enlarged epiphyses (HP:0010580)0.73082589
121Esophageal varix (HP:0002040)0.68462045
122Abnormal foot bone ossification (HP:0010675)0.66767994
123Stage 5 chronic kidney disease (HP:0003774)0.65891196
124Amelogenesis imperfecta (HP:0000705)0.63520224
125Abnormality of carpal bone ossification (HP:0006257)0.63084579
126Choanal stenosis (HP:0000452)0.61497472
127Visceral angiomatosis (HP:0100761)0.60816252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR17.78282315
2WNK46.66227753
3STK392.68193844
4BCKDK2.31652564
5SGK4942.07957666
6SGK2232.07957666
7WNK311.8509273
8SGK21.79111136
9WNK11.69369137
10PDK41.62253478
11PDK31.62253478
12STK38L1.61248474
13SGK31.51631899
14NEK11.32235329
15PDK21.28346257
16MST40.88740761
17STK380.85283170
18MST1R0.84292943
19LRRK20.67903003
20TIE10.64265862
21SGK10.57024195
22PINK10.53436286
23EPHB10.51680962
24TGFBR20.51520891
25FGFR40.50601960
26ERN10.49851803
27PRKAA10.48068925
28GSK3A0.45084293
29TRIB30.42197234
30PAK40.40679720
31PTK60.40647567
32GRK60.37778664
33MAP3K30.36578805
34MAPK150.35621900
35PIK3CG0.34234233
36MAP3K70.32730997
37PTK20.32539778
38AKT30.30803722
39PDPK10.29336192
40STK100.26153659
41PAK30.25507103
42FER0.25443350
43PRKD20.24841176
44DYRK1B0.23351769
45ABL20.22687603
46MET0.22113371
47MYLK0.21043982
48PDK10.20909900
49PTK2B0.20164083
50PRKCD0.19459785
51PRKAA20.18620594
52NTRK10.18487515
53PRKCI0.18316226
54PRKCH0.17947890
55PKN20.17095528
56PRKCZ0.16870553
57MAP3K20.15948375
58PRPF4B0.15645411
59RIPK10.15512598
60MAPK110.13343854
61INSRR0.12769463
62PRKD30.11874802
63MINK10.11704308
64BMX0.10623550
65NLK0.09069246
66SCYL20.08144450
67JAK20.07541536
68PRKCA0.07434426
69AKT20.06835429
70MAP3K110.06205674
71MAP2K30.05197414
72PDGFRA0.05047892
73* PRKACA0.04554005
74SRC0.03996573
75EPHA30.03757977
76LATS10.03716790
77MTOR0.03530245
78EPHB20.03522822
79ROCK10.03201025
80NME10.03172534
81ERBB40.03163849
82MAPK120.02809831
83FRK0.02544530
84DMPK0.01892456
85FGFR30.01433441
86RET0.01377553
87IRAK20.01135075
88STK110.01104628
89CDC42BPA0.01086728
90DAPK20.00921974
91CSNK1A1L0.00812457
92* PRKACG0.00590005
93EPHA40.00459687
94INSR0.00309632
95MAPKAPK30.00216817
96TESK10.00215898
97STK30.00054010
98MARK2-0.0723750
99HIPK2-0.0716857
100RPS6KA2-0.0713940
101MAP2K2-0.0691336
102FGFR2-0.0665607
103MAP3K1-0.0663780
104CDK12-0.0646066
105ABL1-0.0623538
106NTRK3-0.0612499
107TAOK2-0.0593927
108* RPS6KA3-0.0580392
109PIK3CA-0.0569187
110MAPK8-0.0560267
111PRKCE-0.0554003
112MAPK10-0.0551272
113BCR-0.0548911
114MAPK3-0.0547443
115* CSNK1A1-0.0534489
116ICK-0.0482737
117TGFBR1-0.0480913
118PRKD1-0.0472809
119SIK1-0.0466068
120NEK9-0.0452141
121TRPM7-0.0437523
122DAPK1-0.0433879
123IGF1R-0.0431204
124PRKCG-0.0428958
125MAP3K12-0.0428141
126GRK1-0.0407536
127MAP2K6-0.0381419
128MELK-0.0368638
129LATS2-0.0367738
130KSR1-0.0349304
131MAP2K1-0.0322189
132JAK1-0.0294957
133PIM1-0.0261318
134YES1-0.0260194
135CAMKK2-0.0212939
136MARK3-0.0209505
137BRSK2-0.0190587
138CDK5-0.0185084
139ROCK2-0.0141948
140CSK-0.0106233
141PRKCQ-0.0085535
142KSR2-0.0014008

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.34649710
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.73292916
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.44959301
4Propanoate metabolism_Homo sapiens_hsa006403.21364111
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21276850
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.18556245
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05820200
8Butanoate metabolism_Homo sapiens_hsa006503.05310933
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.93284102
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51635596
11Fatty acid degradation_Homo sapiens_hsa000712.36135285
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.31010108
13Collecting duct acid secretion_Homo sapiens_hsa049662.29626542
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22025107
15Pyruvate metabolism_Homo sapiens_hsa006202.14359253
16Peroxisome_Homo sapiens_hsa041462.12220457
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08606670
18Sulfur metabolism_Homo sapiens_hsa009202.07191813
19Tryptophan metabolism_Homo sapiens_hsa003802.02214460
20Bile secretion_Homo sapiens_hsa049761.96444986
21Carbon metabolism_Homo sapiens_hsa012001.89546853
22Vitamin digestion and absorption_Homo sapiens_hsa049771.87559767
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76575657
24Fatty acid metabolism_Homo sapiens_hsa012121.72651147
25Endometrial cancer_Homo sapiens_hsa052131.62910483
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62503407
27Glutathione metabolism_Homo sapiens_hsa004801.54551544
28beta-Alanine metabolism_Homo sapiens_hsa004101.53616112
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49837414
30Mineral absorption_Homo sapiens_hsa049781.48112827
31Non-small cell lung cancer_Homo sapiens_hsa052231.40828574
32Nitrogen metabolism_Homo sapiens_hsa009101.37063672
33Oxidative phosphorylation_Homo sapiens_hsa001901.35700014
34Protein digestion and absorption_Homo sapiens_hsa049741.34492750
35Arginine biosynthesis_Homo sapiens_hsa002201.33682776
36Pancreatic cancer_Homo sapiens_hsa052121.28404812
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26339533
38Biosynthesis of amino acids_Homo sapiens_hsa012301.24794468
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18437170
40PPAR signaling pathway_Homo sapiens_hsa033201.18242426
41Lysine degradation_Homo sapiens_hsa003101.11298592
42Glioma_Homo sapiens_hsa052141.10041704
43Arginine and proline metabolism_Homo sapiens_hsa003301.09828272
44Melanoma_Homo sapiens_hsa052181.09731029
45Other glycan degradation_Homo sapiens_hsa005111.00214747
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95662576
47Parkinsons disease_Homo sapiens_hsa050120.93838953
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89141323
49FoxO signaling pathway_Homo sapiens_hsa040680.87679104
50Gastric acid secretion_Homo sapiens_hsa049710.87426520
51Selenocompound metabolism_Homo sapiens_hsa004500.85232173
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84404463
53Fatty acid elongation_Homo sapiens_hsa000620.84096201
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.81256440
55Fructose and mannose metabolism_Homo sapiens_hsa000510.80851866
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.77143196
57Gap junction_Homo sapiens_hsa045400.77121191
58Phenylalanine metabolism_Homo sapiens_hsa003600.76860754
59Starch and sucrose metabolism_Homo sapiens_hsa005000.76337178
60Prostate cancer_Homo sapiens_hsa052150.76140271
61Thyroid hormone synthesis_Homo sapiens_hsa049180.75083893
62ErbB signaling pathway_Homo sapiens_hsa040120.74851383
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74028758
64Folate biosynthesis_Homo sapiens_hsa007900.73749731
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72826458
66Vitamin B6 metabolism_Homo sapiens_hsa007500.72639587
67Cardiac muscle contraction_Homo sapiens_hsa042600.68451858
68Glycerolipid metabolism_Homo sapiens_hsa005610.64996385
69Renin-angiotensin system_Homo sapiens_hsa046140.63417216
70Lysosome_Homo sapiens_hsa041420.62702965
71Pentose phosphate pathway_Homo sapiens_hsa000300.60509272
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58775314
73Chemical carcinogenesis_Homo sapiens_hsa052040.57576362
74Alzheimers disease_Homo sapiens_hsa050100.57154859
75Thyroid cancer_Homo sapiens_hsa052160.56943806
76HIF-1 signaling pathway_Homo sapiens_hsa040660.56890720
77Histidine metabolism_Homo sapiens_hsa003400.56456677
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54296498
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52210235
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51113348
81Focal adhesion_Homo sapiens_hsa045100.48534299
82Metabolic pathways_Homo sapiens_hsa011000.47286944
83Vibrio cholerae infection_Homo sapiens_hsa051100.42798127
84Complement and coagulation cascades_Homo sapiens_hsa046100.40298528
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.37943964
86Huntingtons disease_Homo sapiens_hsa050160.37472736
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35374753
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.33689133
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.31266151
90Circadian rhythm_Homo sapiens_hsa047100.30347738
91Synaptic vesicle cycle_Homo sapiens_hsa047210.29972111
92* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29259262
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28937582
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.25814021
95Tyrosine metabolism_Homo sapiens_hsa003500.24420823
96ABC transporters_Homo sapiens_hsa020100.23774865
97Rap1 signaling pathway_Homo sapiens_hsa040150.22405862
98Retinol metabolism_Homo sapiens_hsa008300.21936582
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.21716514
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21137193
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16622674
102Pathways in cancer_Homo sapiens_hsa052000.15820201
103Sulfur relay system_Homo sapiens_hsa041220.14874932
104Arachidonic acid metabolism_Homo sapiens_hsa005900.14799417
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.14741800
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.13911336
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13246893
108Bladder cancer_Homo sapiens_hsa052190.12088932
109Insulin resistance_Homo sapiens_hsa049310.11981323
110Choline metabolism in cancer_Homo sapiens_hsa052310.10191610
111Hepatitis C_Homo sapiens_hsa051600.08717038
112Tight junction_Homo sapiens_hsa045300.08584856
113Sphingolipid metabolism_Homo sapiens_hsa006000.06458223
114Adherens junction_Homo sapiens_hsa045200.06415182
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05983877
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05732598
117Ras signaling pathway_Homo sapiens_hsa040140.05449339
118Rheumatoid arthritis_Homo sapiens_hsa053230.05098483
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.04921535
120Glucagon signaling pathway_Homo sapiens_hsa049220.04656159
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.03911586
122Galactose metabolism_Homo sapiens_hsa000520.03751832
123AMPK signaling pathway_Homo sapiens_hsa041520.03631503
124Salivary secretion_Homo sapiens_hsa049700.03335544
125Pancreatic secretion_Homo sapiens_hsa049720.02815404
126ECM-receptor interaction_Homo sapiens_hsa04512-0.0414679
127Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0268696

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