AQP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.72476165
2cilium or flagellum-dependent cell motility (GO:0001539)8.70835509
3establishment of skin barrier (GO:0061436)8.46220309
4regulation of water loss via skin (GO:0033561)7.96017321
5motile cilium assembly (GO:0044458)7.38257180
6cilium movement (GO:0003341)7.03167702
7xenobiotic catabolic process (GO:0042178)6.68567914
8negative regulation of keratinocyte proliferation (GO:0010839)6.53685182
9primary alcohol catabolic process (GO:0034310)6.16842524
10hair cycle (GO:0042633)6.13232411
11molting cycle (GO:0042303)6.13232411
12bundle of His cell to Purkinje myocyte communication (GO:0086069)6.07651457
13multicellular organismal water homeostasis (GO:0050891)6.07326942
14keratinocyte development (GO:0003334)5.88128511
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.74511624
16epithelial cilium movement (GO:0003351)5.54315118
17surfactant homeostasis (GO:0043129)5.17164346
18ethanol metabolic process (GO:0006067)5.03767526
19response to nitrosative stress (GO:0051409)5.02940126
20keratinocyte proliferation (GO:0043616)4.96522639
21water homeostasis (GO:0030104)4.94066635
22epidermis development (GO:0008544)4.89975349
23glucuronate metabolic process (GO:0019585)4.89533991
24uronic acid metabolic process (GO:0006063)4.89533991
25keratinocyte differentiation (GO:0030216)4.81809014
26diterpenoid biosynthetic process (GO:0016102)4.77264435
27interferon-gamma secretion (GO:0072643)4.75926738
28intermediate filament organization (GO:0045109)4.69503951
29vitamin transmembrane transport (GO:0035461)4.46040626
30lipoxygenase pathway (GO:0019372)4.42918747
31axoneme assembly (GO:0035082)4.41748204
32regulation of keratinocyte proliferation (GO:0010837)4.40186619
33peptide cross-linking (GO:0018149)4.35673681
34pyrimidine-containing compound transmembrane transport (GO:0072531)4.35551218
35regulation of skeletal muscle contraction (GO:0014819)4.35179621
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.29112624
37cellular glucuronidation (GO:0052695)4.20780269
38tolerance induction (GO:0002507)4.18490275
39regulation of chemokine secretion (GO:0090196)4.16028647
40L-ascorbic acid metabolic process (GO:0019852)4.08778478
41ectoderm development (GO:0007398)4.05895645
42chemical homeostasis within a tissue (GO:0048875)4.04489879
43regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.97191334
44epithelial cell differentiation involved in prostate gland development (GO:0060742)3.95364309
45epidermal cell differentiation (GO:0009913)3.94614328
46negative regulation of humoral immune response (GO:0002921)3.92178337
47outer ear morphogenesis (GO:0042473)3.89003878
48ethanol oxidation (GO:0006069)3.86474228
49glutathione derivative metabolic process (GO:1901685)3.81721896
50glutathione derivative biosynthetic process (GO:1901687)3.81721896
51regulation of hair follicle development (GO:0051797)3.79376676
52intestinal epithelial cell development (GO:0060576)3.78402765
53left/right pattern formation (GO:0060972)3.75767103
54negative regulation of cell fate commitment (GO:0010454)3.74028759
55planar cell polarity pathway involved in neural tube closure (GO:0090179)3.73512749
56* one-carbon compound transport (GO:0019755)3.69502725
57folic acid transport (GO:0015884)3.61017260
58negative regulation of B cell mediated immunity (GO:0002713)3.60705493
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.60705493
60lateral sprouting from an epithelium (GO:0060601)3.60113036
61detection of bacterium (GO:0016045)3.58989878
62positive regulation of hair follicle development (GO:0051798)3.58608453
63positive regulation of hair cycle (GO:0042635)3.58608453
64negative regulation of cell fate specification (GO:0009996)3.53770571
65regulation of interleukin-5 production (GO:0032674)3.53065853
66regulation of secondary heart field cardioblast proliferation (GO:0003266)3.52982268
67regulation of cardioblast proliferation (GO:0003264)3.52982268
68lung epithelium development (GO:0060428)3.52305409
69regulation of phospholipase A2 activity (GO:0032429)3.51759285
70retinol metabolic process (GO:0042572)3.47772633
71regulation of apoptotic process involved in morphogenesis (GO:1902337)3.47235890
72positive regulation of epidermis development (GO:0045684)3.47087948
73regulation of interleukin-13 production (GO:0032656)3.43647735
74gap junction assembly (GO:0016264)3.42929489
75hormone catabolic process (GO:0042447)3.40311180
76primary alcohol metabolic process (GO:0034308)3.36540348
77positive regulation of tolerance induction (GO:0002645)3.35403476
78intermediate filament cytoskeleton organization (GO:0045104)3.31504642
79negative regulation of epidermis development (GO:0045683)3.27761712
80detection of other organism (GO:0098543)3.27229406
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.23307386
82phosphatidylserine acyl-chain remodeling (GO:0036150)3.22860695
83long-chain fatty acid biosynthetic process (GO:0042759)3.22270552
84hypotonic response (GO:0006971)3.22178651
85intermediate filament-based process (GO:0045103)3.20779633
86atrioventricular valve morphogenesis (GO:0003181)3.12489895
87pharyngeal system development (GO:0060037)3.12287980
88notochord development (GO:0030903)3.11312553
89eyelid development in camera-type eye (GO:0061029)3.09671121
90retinoic acid metabolic process (GO:0042573)3.08705973
91regulation of germinal center formation (GO:0002634)3.08311067
92cell surface receptor signaling pathway involved in heart development (GO:0061311)3.07712513
93regulation of cell proliferation involved in kidney development (GO:1901722)3.07672996
94establishment of apical/basal cell polarity (GO:0035089)3.06542593
95positive regulation of epidermal cell differentiation (GO:0045606)3.04179133
96negative regulation of chondrocyte differentiation (GO:0032331)3.00482105
97ribosomal small subunit biogenesis (GO:0042274)2.99273956
98terpenoid biosynthetic process (GO:0016114)2.98497878
99O-glycan processing (GO:0016266)2.97440708
100* renal absorption (GO:0070293)2.93960176
101cell-substrate junction assembly (GO:0007044)2.93358107
102G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91255645
103maturation of SSU-rRNA (GO:0030490)2.89769507
104response to xenobiotic stimulus (GO:0009410)2.89390606
105regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85381872
106myoblast migration (GO:0051451)2.84762117
107female gonad development (GO:0008585)2.83749629
108* regulation of epidermis development (GO:0045682)2.83122091
109cochlea morphogenesis (GO:0090103)2.82106602
110positive regulation of interleukin-8 secretion (GO:2000484)2.76861257
111regulation of tolerance induction (GO:0002643)2.76439012
112lymph vessel development (GO:0001945)2.76277493
113modified amino acid transport (GO:0072337)2.74832522
114left/right axis specification (GO:0070986)2.74773499
115calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.73741093
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.73669010
117negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72579216
118lung-associated mesenchyme development (GO:0060484)2.71914752
119establishment of planar polarity (GO:0001736)2.71259838
120establishment of tissue polarity (GO:0007164)2.71259838
121glomerular epithelial cell development (GO:0072310)2.69885701
122prostanoid metabolic process (GO:0006692)2.69797991
123prostaglandin metabolic process (GO:0006693)2.69797991
124iron ion import (GO:0097286)2.69230599
125microtubule bundle formation (GO:0001578)2.68321723
126hair follicle morphogenesis (GO:0031069)2.66582754
127dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66448145
128negative regulation of interferon-gamma production (GO:0032689)2.66371452
129ventricular system development (GO:0021591)2.64779807
130exogenous drug catabolic process (GO:0042738)2.63379843
131phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62262287
132hair cycle process (GO:0022405)2.62161282
133molting cycle process (GO:0022404)2.62161282
134hydrogen peroxide biosynthetic process (GO:0050665)2.61448996
135regulation of hair cycle (GO:0042634)2.60814611
136phospholipid scrambling (GO:0017121)2.60352975
137bone remodeling (GO:0046849)2.59823033
138glutathione metabolic process (GO:0006749)2.58808265
139cellular response to antibiotic (GO:0071236)2.58094722
140progesterone metabolic process (GO:0042448)2.57409366
141skin morphogenesis (GO:0043589)2.55940229
142linoleic acid metabolic process (GO:0043651)2.55271775
143establishment of monopolar cell polarity (GO:0061162)2.54922202
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.54922202
145replicative senescence (GO:0090399)2.54451558
146epithelium development (GO:0060429)2.54345450
147phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.53053464
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53033545
149regulation of cell fate specification (GO:0042659)2.52980022
150heart valve morphogenesis (GO:0003179)2.52854847
151trophectodermal cell differentiation (GO:0001829)2.52328834
152regulation of glomerular filtration (GO:0003093)2.52148151
153purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50947231
1543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50947231
155sodium ion homeostasis (GO:0055078)2.49019470
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.45852977
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45671289
158regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.44053325
159negative regulation of adaptive immune response (GO:0002820)2.42700750
160polarized epithelial cell differentiation (GO:0030859)2.41637896
161negative regulation of glycoprotein biosynthetic process (GO:0010561)2.39740590
162negative regulation of T cell differentiation in thymus (GO:0033085)2.38555637
163regulation of ruffle assembly (GO:1900027)2.37712749
164epithelial cell-cell adhesion (GO:0090136)2.36845938
165phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.36349347
166regulation of cilium movement (GO:0003352)2.36180422
167antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34395885
168epoxygenase P450 pathway (GO:0019373)2.34048218
169regulation of metalloenzyme activity (GO:0048552)2.31001464
170phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.28524108
171regulation of cholesterol homeostasis (GO:2000188)2.27681423
172reactive oxygen species biosynthetic process (GO:1903409)2.25793230
173axonemal dynein complex assembly (GO:0070286)10.7569828
174desmosome organization (GO:0002934)10.7219388
175hemidesmosome assembly (GO:0031581)10.5758398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.27129989
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.74945748
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.45291404
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.45291404
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.45291404
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.23897317
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.19883449
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.00266283
9* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.52321663
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.39363506
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.36650518
12ZNF263_19887448_ChIP-Seq_K562_Human2.32762177
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.27839537
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.25896691
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.23808253
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03206952
17TP63_17297297_ChIP-ChIP_HaCaT_Human13.5942996
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.91278286
19* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.90222009
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86982814
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86982814
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84883124
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72935776
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70818900
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60418083
26LXR_22292898_ChIP-Seq_THP-1_Human1.55794702
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51236499
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50744097
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50245780
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.49280418
31* SMC4_20622854_ChIP-Seq_HELA_Human1.48510233
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46830932
33* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46811782
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45315411
35* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42755025
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42686998
37* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42551516
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40988495
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39910417
40* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39374526
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38677394
42* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37729070
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35847588
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35547476
45CLOCK_20551151_ChIP-Seq_293T_Human1.35372665
46GATA1_19941826_ChIP-Seq_K562_Human1.34074212
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.32421621
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31866155
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.31249627
50* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30986508
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30036020
52KLF5_25053715_ChIP-Seq_YYC3_Human1.29650077
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29075097
54* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28488138
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.27284546
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26097693
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25173628
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23528058
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22968478
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22943019
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22756407
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.20071629
63AR_21909140_ChIP-Seq_LNCAP_Human1.19280743
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18329196
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17405735
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16953222
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16951716
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.14749677
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14057882
70* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13776013
71* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13771707
72GATA6_25053715_ChIP-Seq_YYC3_Human1.13093320
73CREB1_26743006_Chip-Seq_LNCaP_Human1.12961028
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.11651173
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.09973246
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09620756
77* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09223482
78* GATA3_24758297_ChIP-Seq_MCF-7_Human1.08505894
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.08165406
80GATA4_25053715_ChIP-Seq_YYC3_Human1.08030358
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.07263361
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.06937049
83BCOR_27268052_Chip-Seq_Bcells_Human1.04721303
84P68_20966046_ChIP-Seq_HELA_Human1.04627052
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03992246
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.03799120
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03162498
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03040799
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03011541
90GATA2_19941826_ChIP-Seq_K562_Human1.02572385
91TCF7_22412390_ChIP-Seq_EML_Mouse1.02379095
92* SOX2_20726797_ChIP-Seq_SW620_Human1.02357448
93PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02284513
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.01993009
95CTCF_27219007_Chip-Seq_Bcells_Human1.01838869
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.01309084
97RUNX_20019798_ChIP-Seq_JUKART_Human1.00610057
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00519187
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99883444
100ATF3_27146783_Chip-Seq_COLON_Human0.99658816
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98415660
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98202085
103TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97214646
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96894070
105MAF_26560356_Chip-Seq_TH1_Human0.95078347
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95060827
107* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94885543
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.94829575
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.94829575
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93917523
111FOXA1_25552417_ChIP-Seq_VCAP_Human0.93781726
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.93650037
113POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93300794
114DROSHA_22980978_ChIP-Seq_HELA_Human0.92609977
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.92529901
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89951101
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89944413
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89922331
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89422327
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89230795
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87962738
122* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87432634
123VDR_24763502_ChIP-Seq_THP-1_Human0.87243818
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87122564
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.86658779
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85943027
127GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85682077
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83771326
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83704460
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83405713
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82798531
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82749659
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82564982
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82288280
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.82224048
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81603853
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80417013
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79894539
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78352458
140* TP63_22573176_ChIP-Seq_HFKS_Human0.76923815
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76458659
142CJUN_26792858_Chip-Seq_BT549_Human0.75082541
143MYC_18555785_ChIP-Seq_MESCs_Mouse0.74360836
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73931583
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.73568429
146TP63_19390658_ChIP-ChIP_HaCaT_Human0.72588767
147RXR_22108803_ChIP-Seq_LS180_Human0.72557435
148TP63_23658742_ChIP-Seq_EP156T_Human0.72157989
149* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.72067054
150AR_21572438_ChIP-Seq_LNCaP_Human0.71425144
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71359407
152AHR_22903824_ChIP-Seq_MCF-7_Human0.68932468
153NANOG_16518401_ChIP-PET_MESCs_Mouse0.66723247
154KAP1_27257070_Chip-Seq_ESCs_Mouse0.66008053
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64976379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.78296038
2MP0000579_abnormal_nail_morphology4.34907302
3MP0002254_reproductive_system_inflammat3.93527020
4MP0003941_abnormal_skin_development3.64721931
5MP0000762_abnormal_tongue_morphology3.57582871
6MP0010030_abnormal_orbit_morphology3.23254854
7MP0002098_abnormal_vibrissa_morphology3.20565315
8MP0005501_abnormal_skin_physiology3.10266224
9MP0000467_abnormal_esophagus_morphology3.06608964
10MP0000383_abnormal_hair_follicle2.85660692
11MP0010234_abnormal_vibrissa_follicle2.84602761
12MP0001216_abnormal_epidermal_layer2.75362863
13MP0001346_abnormal_lacrimal_gland2.70000435
14MP0002060_abnormal_skin_morphology2.64841406
15* MP0008789_abnormal_olfactory_epithelium2.58435013
16MP0003453_abnormal_keratinocyte_physiol2.54575252
17* MP0005499_abnormal_olfactory_system2.53704739
18* MP0005394_taste/olfaction_phenotype2.53704739
19MP0004381_abnormal_hair_follicle2.53106321
20MP0003705_abnormal_hypodermis_morpholog2.48247677
21MP0005275_abnormal_skin_tensile2.36343574
22MP0000377_abnormal_hair_follicle2.31233525
23MP0010678_abnormal_skin_adnexa2.21492611
24MP0000566_synostosis2.16695368
25MP0000647_abnormal_sebaceous_gland2.15272539
26MP0003566_abnormal_cell_adhesion2.14885680
27MP0003191_abnormal_cellular_cholesterol2.09935466
28MP0009053_abnormal_anal_canal2.05634016
29MP0000678_abnormal_parathyroid_gland1.95262659
30MP0000427_abnormal_hair_cycle1.89895922
31MP0009780_abnormal_chondrocyte_physiolo1.89804202
32MP0010771_integument_phenotype1.87556793
33MP0002249_abnormal_larynx_morphology1.78383342
34MP0002877_abnormal_melanocyte_morpholog1.74897936
35MP0004019_abnormal_vitamin_homeostasis1.73692835
36MP0001849_ear_inflammation1.60163562
37MP0003763_abnormal_thymus_physiology1.53752776
38MP0002234_abnormal_pharynx_morphology1.46891490
39MP0003786_premature_aging1.46261596
40MP0000516_abnormal_urinary_system1.43958209
41MP0005367_renal/urinary_system_phenotyp1.43958209
42MP0003755_abnormal_palate_morphology1.38569624
43MP0000537_abnormal_urethra_morphology1.38235881
44MP0005377_hearing/vestibular/ear_phenot1.34908994
45MP0003878_abnormal_ear_physiology1.34908994
46MP0004264_abnormal_extraembryonic_tissu1.34556596
47* MP0010155_abnormal_intestine_physiology1.31718946
48MP0008875_abnormal_xenobiotic_pharmacok1.31343152
49MP0000049_abnormal_middle_ear1.30074800
50MP0004947_skin_inflammation1.28842249
51MP0003315_abnormal_perineum_morphology1.27630668
52MP0001191_abnormal_skin_condition1.27563120
53MP0005083_abnormal_biliary_tract1.26107113
54* MP0002233_abnormal_nose_morphology1.23659658
55MP0005023_abnormal_wound_healing1.22463992
56MP0009931_abnormal_skin_appearance1.21319434
57MP0010352_gastrointestinal_tract_polyps1.21246782
58MP0001188_hyperpigmentation1.16036789
59MP0000367_abnormal_coat/_hair1.14077489
60MP0001765_abnormal_ion_homeostasis1.12664384
61MP0001984_abnormal_olfaction1.10806535
62MP0000613_abnormal_salivary_gland1.05803100
63MP0001666_abnormal_nutrient_absorption1.05612043
64MP0002277_abnormal_respiratory_mucosa1.05330804
65MP0005451_abnormal_body_composition1.04909836
66MP0004043_abnormal_pH_regulation1.03736954
67MP0003186_abnormal_redox_activity1.03089633
68MP0005365_abnormal_bile_salt1.02881063
69MP0001790_abnormal_immune_system1.01760285
70MP0005387_immune_system_phenotype1.01760285
71MP0009333_abnormal_splenocyte_physiolog1.01522469
72MP0000858_altered_metastatic_potential1.01520162
73MP0003436_decreased_susceptibility_to1.01297541
74MP0009250_abnormal_appendicular_skeleto1.00680373
75MP0008004_abnormal_stomach_pH1.00545409
76MP0003937_abnormal_limbs/digits/tail_de0.96825918
77MP0005085_abnormal_gallbladder_physiolo0.93854345
78MP0001340_abnormal_eyelid_morphology0.91474514
79MP0002132_abnormal_respiratory_system0.90819580
80MP0009379_abnormal_foot_pigmentation0.90792905
81MP0003136_yellow_coat_color0.90748003
82MP0002282_abnormal_trachea_morphology0.88522504
83MP0001851_eye_inflammation0.88171608
84MP0003938_abnormal_ear_development0.87056865
85MP0003693_abnormal_embryo_hatching0.86508370
86MP0001243_abnormal_dermal_layer0.86251638
87MP0002009_preneoplasia0.84404885
88MP0000627_abnormal_mammary_gland0.84319833
89MP0003300_gastrointestinal_ulcer0.83725960
90MP0005025_abnormal_response_to0.82004808
91MP0000534_abnormal_ureter_morphology0.81633497
92MP0000685_abnormal_immune_system0.81348608
93MP0003866_abnormal_defecation0.80655904
94MP0005165_increased_susceptibility_to0.80233375
95MP0003303_peritoneal_inflammation0.79906102
96* MP0009643_abnormal_urine_homeostasis0.79839615
97MP0003656_abnormal_erythrocyte_physiolo0.79682918
98MP0002111_abnormal_tail_morphology0.79455834
99MP0000538_abnormal_urinary_bladder0.77311738
100MP0002653_abnormal_ependyma_morphology0.76476888
101MP0002177_abnormal_outer_ear0.75828009
102MP0001919_abnormal_reproductive_system0.75554064
103MP0005076_abnormal_cell_differentiation0.75074742
104MP0005508_abnormal_skeleton_morphology0.74105508
105MP0002405_respiratory_system_inflammati0.73400035
106MP0002168_other_aberrant_phenotype0.73257056
107MP0005164_abnormal_response_to0.72675142
108MP0005360_urolithiasis0.72096079
109MP0005248_abnormal_Harderian_gland0.71441213
110MP0001958_emphysema0.67633632
111MP0003724_increased_susceptibility_to0.65400890
112MP0005166_decreased_susceptibility_to0.65319582
113MP0000432_abnormal_head_morphology0.65187848
114* MP0002136_abnormal_kidney_physiology0.65053821
115MP0003718_maternal_effect0.64635724
116MP0004185_abnormal_adipocyte_glucose0.63988255
117MP0002166_altered_tumor_susceptibility0.63953813
118MP0005636_abnormal_mineral_homeostasis0.63893315
119MP0001873_stomach_inflammation0.63737395
120MP0003111_abnormal_nucleus_morphology0.63731311
121MP0000470_abnormal_stomach_morphology0.63472872
122MP0003936_abnormal_reproductive_system0.62319785
123MP0001533_abnormal_skeleton_physiology0.61074704
124MP0001286_abnormal_eye_development0.59823120
125MP0003638_abnormal_response/metabolism_0.59796966
126MP0003935_abnormal_craniofacial_develop0.58730678
127MP0004883_abnormal_blood_vessel0.57418674
128MP0004782_abnormal_surfactant_physiolog0.57294324
129MP0000428_abnormal_craniofacial_morphol0.55267962
130MP0003195_calcinosis0.55104559
131MP0008260_abnormal_autophagy0.54965634
132MP0002148_abnormal_hypersensitivity_rea0.54226228
133MP0004885_abnormal_endolymph0.54166335
134MP0005671_abnormal_response_to0.53906848
135MP0003806_abnormal_nucleotide_metabolis0.52639011
136MP0004957_abnormal_blastocyst_morpholog0.51895953
137MP0001784_abnormal_fluid_regulation0.51669710
138MP0001800_abnormal_humoral_immune0.50920213
139MP0003075_altered_response_to0.50914870
140MP0002139_abnormal_hepatobiliary_system0.50808316
141MP0001853_heart_inflammation0.50618977
142MP0000477_abnormal_intestine_morphology0.50134679
143MP0005409_darkened_coat_color0.49344019
144MP0003828_pulmonary_edema0.48516581
145MP0002116_abnormal_craniofacial_bone0.48302434
146MP0000163_abnormal_cartilage_morphology0.46671248
147MP0002092_abnormal_eye_morphology0.45594621
148MP0001542_abnormal_bone_strength0.44569446
149MP0009840_abnormal_foam_cell0.43301191

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.58387160
2Abnormal respiratory motile cilium morphology (HP:0005938)7.32577156
3Abnormal respiratory epithelium morphology (HP:0012253)7.32577156
4Abnormal respiratory motile cilium physiology (HP:0012261)7.31598678
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.03134552
6Absent/shortened dynein arms (HP:0200106)7.03134552
7Abnormal ciliary motility (HP:0012262)7.00474845
8Rhinitis (HP:0012384)6.89014617
9Fragile nails (HP:0001808)6.41133533
10Chronic bronchitis (HP:0004469)6.36723204
11Plantar hyperkeratosis (HP:0007556)6.11648205
12Lip pit (HP:0100267)6.03362667
13Abnormality of nail color (HP:0100643)5.86142865
14Onycholysis (HP:0001806)5.56118524
15Milia (HP:0001056)5.50449592
16Bronchiectasis (HP:0002110)5.37276339
17Nasal polyposis (HP:0100582)5.36148420
18Hypotrichosis (HP:0001006)4.95525134
19Palmoplantar hyperkeratosis (HP:0000972)4.77476304
20Palmar hyperkeratosis (HP:0010765)4.64864604
21Abnormality of the nasal mucosa (HP:0000433)4.48422689
22Right ventricular cardiomyopathy (HP:0011663)4.38405869
23Alopecia of scalp (HP:0002293)4.36443308
24Woolly hair (HP:0002224)4.36022964
25Thick nail (HP:0001805)4.33153629
26Pili torti (HP:0003777)4.11012988
27Abnormal blistering of the skin (HP:0008066)4.05057906
28Nail dystrophy (HP:0008404)3.91584943
29Distal lower limb muscle weakness (HP:0009053)3.57211008
30Natal tooth (HP:0000695)3.56667806
31Bronchitis (HP:0012387)3.55457277
32Sparse eyelashes (HP:0000653)3.43535390
33Atrophic scars (HP:0001075)3.43403557
34Recurrent otitis media (HP:0000403)3.34116550
35Recurrent sinusitis (HP:0011108)3.28415816
36Down-sloping shoulders (HP:0200021)3.23251271
37Sparse scalp hair (HP:0002209)3.17785965
38Eczematoid dermatitis (HP:0000976)2.93622584
39Aplasia cutis congenita (HP:0001057)2.91088769
40Abnormality of the distal phalanges of the toes (HP:0010182)2.90700305
41Oral leukoplakia (HP:0002745)2.83364815
42Increased IgE level (HP:0003212)2.81172838
43Chronic sinusitis (HP:0011109)2.74495352
44Infertility (HP:0000789)2.73619556
45Ridged nail (HP:0001807)2.72237878
46Male infertility (HP:0003251)2.71094568
47Advanced eruption of teeth (HP:0006288)2.68718203
48Esophageal atresia (HP:0002032)2.59907909
49Congenital ichthyosiform erythroderma (HP:0007431)2.56995022
50Erythema (HP:0010783)2.56750671
51Stomach cancer (HP:0012126)2.51243917
52Hyperactive renin-angiotensin system (HP:0000841)2.45052220
53Chronic otitis media (HP:0000389)2.45033256
54Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.42775406
55Abnormality of permanent molar morphology (HP:0011071)2.40807415
56Abnormality of the dental root (HP:0006486)2.40807415
57Taurodontia (HP:0000679)2.40807415
58Popliteal pterygium (HP:0009756)2.38378991
59Pterygium (HP:0001059)2.36186530
60Parakeratosis (HP:0001036)2.33223317
61Hypokalemic alkalosis (HP:0001949)2.30362395
62Follicular hyperkeratosis (HP:0007502)2.29746827
63Stenosis of the external auditory canal (HP:0000402)2.29722536
64Bifid scrotum (HP:0000048)2.29720987
65Hypoplasia of dental enamel (HP:0006297)2.27146177
66Metabolic alkalosis (HP:0200114)2.25553908
67Abnormal hemoglobin (HP:0011902)2.25499561
68Anonychia (HP:0001798)2.25488615
69Laryngomalacia (HP:0001601)2.24612853
70Congenital, generalized hypertrichosis (HP:0004540)2.23759004
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23295070
72Abnormal hair laboratory examination (HP:0003328)2.23274039
73Abnormality of the middle phalanges of the toes (HP:0010183)2.21082768
74Abnormality of molar (HP:0011077)2.20593031
75Abnormality of molar morphology (HP:0011070)2.20593031
76Renal salt wasting (HP:0000127)2.20071507
77Skin pits (HP:0100276)2.17458771
78Nasolacrimal duct obstruction (HP:0000579)2.15550348
79Abnormality of the dental pulp (HP:0006479)2.14060504
80Hyperkalemia (HP:0002153)2.12757717
81Abnormality of secondary sexual hair (HP:0009888)2.12514957
82Abnormality of the axillary hair (HP:0100134)2.12514957
83Gangrene (HP:0100758)2.12182101
84Sex reversal (HP:0012245)2.11744468
85Abnormal sex determination (HP:0012244)2.11744468
86Atelectasis (HP:0100750)2.11224856
87Malnutrition (HP:0004395)2.10727809
88Decreased circulating renin level (HP:0003351)2.08597859
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06989092
90Ectropion (HP:0000656)2.06735787
91Selective tooth agenesis (HP:0001592)2.05568980
92Interstitial pulmonary disease (HP:0006530)2.04958031
93Abnormality of chloride homeostasis (HP:0011422)2.04474461
94Preauricular pit (HP:0004467)2.04316535
95Periauricular skin pits (HP:0100277)2.04316535
96Erythroderma (HP:0001019)2.03983566
97Hypoplastic labia majora (HP:0000059)2.03866527
98Blepharitis (HP:0000498)2.03465400
99Curly hair (HP:0002212)2.03322886
100Absent eyelashes (HP:0000561)2.02638951
101Hypohidrosis (HP:0000966)2.00316810
102Humeroradial synostosis (HP:0003041)1.99098451
103Synostosis involving the elbow (HP:0003938)1.99098451
104Fragile skin (HP:0001030)1.99017110
105Conjunctival hamartoma (HP:0100780)1.98442135
106Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97187596
107Rough bone trabeculation (HP:0100670)1.96831610
108Abnormality of the phalanges of the 5th finger (HP:0004213)1.95368100
109Abnormality of the renal collecting system (HP:0004742)1.94861276
110Aplasia involving bones of the extremities (HP:0009825)1.94042636
111Aplasia involving bones of the upper limbs (HP:0009823)1.94042636
112Aplasia of the phalanges of the hand (HP:0009802)1.94042636
113Concave nail (HP:0001598)1.92821424
114Abnormality of the fingernails (HP:0001231)1.91234751
115Cheilitis (HP:0100825)1.90670564
116Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90052187
117Aplasia/Hypoplasia of the scapulae (HP:0006713)1.89710600
118Hypoplastic scapulae (HP:0000882)1.89710600
119Furrowed tongue (HP:0000221)1.87190456
120Abnormality of the salivary glands (HP:0010286)1.86267209
121Increased connective tissue (HP:0009025)1.86203216
122Abnormality of the labia majora (HP:0012881)1.84463437
123Upper limb muscle weakness (HP:0003484)1.84383048
124Palmoplantar keratoderma (HP:0000982)1.83417993
125Trismus (HP:0000211)1.83202593
126Ventricular tachycardia (HP:0004756)1.83013123
127Morphological abnormality of the middle ear (HP:0008609)1.82481320
128Tetany (HP:0001281)1.82447299
129Abnormality of the lacrimal duct (HP:0011481)1.82007917
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81726228
131Stillbirth (HP:0003826)1.81675812
132Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.80891930
133Dehydration (HP:0001944)1.80041661
134Premature loss of primary teeth (HP:0006323)1.79312893
135Abnormality of the 2nd finger (HP:0004100)1.79062786
136Pustule (HP:0200039)1.78458691
137Hyperaldosteronism (HP:0000859)1.77220448
138Corneal erosion (HP:0200020)1.76494774
139Pruritus (HP:0000989)1.75055605
140Abnormality of renin-angiotensin system (HP:0000847)1.73896562
141Recurrent bronchitis (HP:0002837)1.62086952
142Abnormality of sodium homeostasis (HP:0010931)1.61696117
143Ventricular fibrillation (HP:0001663)1.53658613
144Flat acetabular roof (HP:0003180)1.53597627
145Occipital encephalocele (HP:0002085)1.52744003
146Xerostomia (HP:0000217)1.52427591
147Acanthosis nigricans (HP:0000956)1.52073463
148Hypergammaglobulinemia (HP:0010702)1.49182619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.69633811
2MAP3K34.20261834
3EPHB23.90997316
4ZAK3.62964059
5MST43.35203110
6MST1R3.28213593
7RPS6KB23.04605976
8MAPKAPK32.98654503
9STK38L2.40226354
10EEF2K2.32445661
11WNK32.27646863
12SMG12.21966677
13TAOK22.09985329
14BUB12.05317779
15AKT31.88616351
16FER1.87363185
17NME11.76551758
18TRIB31.76255940
19MAPK151.75579570
20TTK1.66053701
21PDK21.65522313
22PBK1.64869489
23TRPM71.59499229
24FGFR31.57472887
25GRK61.54535791
26TSSK61.48381144
27CSK1.48293545
28LATS11.46521685
29PRPF4B1.44956437
30SIK11.39337187
31PRKCI1.36806252
32ERN11.36789882
33TAOK11.35126751
34STK101.31308395
35ICK1.30666603
36ERBB31.29952058
37TGFBR11.29681108
38MAP3K111.17219440
39IRAK31.15696714
40TBK11.13078419
41MAP2K21.12746691
42ZAP701.09854215
43MET1.09602198
44MAP3K71.07854250
45EPHA31.07124672
46TYK21.04422512
47RPS6KA41.03604791
48MAP3K21.01931435
49MARK21.01070075
50STK240.99293520
51PIM20.96822588
52MAP3K10.95753933
53MAP3K130.94845815
54OXSR10.92795047
55RIPK40.92534907
56PTK60.92245000
57MAP2K30.91591065
58MAPK120.88501136
59GRK10.84424930
60PDK40.80667852
61PDK30.80667852
62MAP2K60.80292388
63CDK60.77938969
64NEK10.75676707
65CDK70.72117907
66CDK120.71412958
67JAK10.70936997
68MAPKAPK20.70273824
69BLK0.68458420
70DDR20.68107128
71WEE10.67444129
72NLK0.66316136
73MAP3K120.65724661
74EPHB10.65563296
75RIPK10.64731396
76ERBB40.64033314
77CDC42BPA0.63891443
78AURKB0.62864482
79KSR20.62289308
80NUAK10.62253026
81PDPK10.59609609
82AURKA0.59098038
83LRRK20.59038038
84STK40.58016587
85PRKAA20.57639746
86PAK40.56951812
87MAP4K10.56828332
88PINK10.55864026
89JAK30.53817162
90NEK60.53407816
91LATS20.52405842
92STK30.52303208
93STK380.51978300
94MATK0.51692964
95IKBKB0.51571307
96MAPK70.50310724
97TGFBR20.49462501
98CAMKK10.48826370
99MKNK20.48639622
100BCR0.48331536
101MAP3K80.47532600
102PIM10.47461310
103WNK40.46252681
104IKBKE0.45296677
105ADRBK20.43303195
106RPS6KA10.43198399
107BMPR1B0.42193382
108GSK3A0.41584807
109SGK2230.41143431
110SGK4940.41143431
111ITK0.40735275
112RET0.40023646
113FGFR10.39255582
114SGK30.39240298
115MAPK110.39172408
116MAP2K10.38822457
117PDGFRB0.38556682
118RPS6KC10.38529379
119RPS6KL10.38529379
120HIPK20.37886954
121PTK20.37776365
122ERBB20.37525939
123TESK10.37086560
124BTK0.36510739
125IRAK10.35858614
126SRPK10.35438324
127RPS6KA20.35417640
128PLK10.35217746
129RPS6KB10.35008650
130CDK30.34978132
131MAP3K60.34957754
132MTOR0.34926972
133CHUK0.34751372
134HCK0.34086276
135DYRK30.33544660
136RPS6KA60.33319886
137PRKD20.33116901
138MAP3K140.32701830
139DYRK1B0.32656231
140TAOK30.32478478
141AKT20.32410159
142BMX0.31361169
143SIK30.30935992
144BCKDK0.30588711
145FGFR40.30571300
146SGK10.30311070
147YES10.30119090
148PIK3CG0.28818317
149MAPKAPK50.28667512
150PLK30.28663539
151ARAF0.27601450
152PRKCD0.24849004
153CSNK1A10.24627363

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.99815275
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.30324441
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.28805724
4Chemical carcinogenesis_Homo sapiens_hsa052043.98132532
5Glutathione metabolism_Homo sapiens_hsa004803.42575593
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87437911
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.63042036
8Retinol metabolism_Homo sapiens_hsa008302.51754344
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.43695884
10Ribosome_Homo sapiens_hsa030102.16015462
11Sulfur relay system_Homo sapiens_hsa041221.89099327
12Sulfur metabolism_Homo sapiens_hsa009201.87700807
13Arachidonic acid metabolism_Homo sapiens_hsa005901.79823765
14Basal cell carcinoma_Homo sapiens_hsa052171.71142259
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49341593
16Hippo signaling pathway_Homo sapiens_hsa043901.48896569
17Mineral absorption_Homo sapiens_hsa049781.45957349
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.44091637
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39259378
20Staphylococcus aureus infection_Homo sapiens_hsa051501.36474951
21Galactose metabolism_Homo sapiens_hsa000521.35975993
22Vitamin digestion and absorption_Homo sapiens_hsa049771.34005250
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33761929
24p53 signaling pathway_Homo sapiens_hsa041151.27813634
25ECM-receptor interaction_Homo sapiens_hsa045121.18420072
26Phenylalanine metabolism_Homo sapiens_hsa003601.18233391
27Caffeine metabolism_Homo sapiens_hsa002321.16568366
28Starch and sucrose metabolism_Homo sapiens_hsa005001.15185931
29Folate biosynthesis_Homo sapiens_hsa007901.15097754
30Arginine biosynthesis_Homo sapiens_hsa002201.14457839
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13880341
32Ether lipid metabolism_Homo sapiens_hsa005651.13209230
33Tight junction_Homo sapiens_hsa045301.11080940
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.11022135
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09256369
36Amoebiasis_Homo sapiens_hsa051461.07531218
37Hedgehog signaling pathway_Homo sapiens_hsa043401.07341678
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07167737
39Proteasome_Homo sapiens_hsa030501.06776311
40Adherens junction_Homo sapiens_hsa045201.06437971
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05542332
42ABC transporters_Homo sapiens_hsa020101.04398739
43TGF-beta signaling pathway_Homo sapiens_hsa043501.04248696
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04037132
45Circadian rhythm_Homo sapiens_hsa047100.98717100
46Collecting duct acid secretion_Homo sapiens_hsa049660.97635561
47Fructose and mannose metabolism_Homo sapiens_hsa000510.96856806
48Linoleic acid metabolism_Homo sapiens_hsa005910.96216332
49Choline metabolism in cancer_Homo sapiens_hsa052310.96003767
50beta-Alanine metabolism_Homo sapiens_hsa004100.95846926
51RNA polymerase_Homo sapiens_hsa030200.95722734
52Acute myeloid leukemia_Homo sapiens_hsa052210.94313627
53Sphingolipid metabolism_Homo sapiens_hsa006000.93863278
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92105017
55Fatty acid degradation_Homo sapiens_hsa000710.91849969
56Hematopoietic cell lineage_Homo sapiens_hsa046400.89010501
57Fat digestion and absorption_Homo sapiens_hsa049750.85503366
58Complement and coagulation cascades_Homo sapiens_hsa046100.84968114
59VEGF signaling pathway_Homo sapiens_hsa043700.83807481
60Notch signaling pathway_Homo sapiens_hsa043300.83554855
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83104776
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80868887
63PPAR signaling pathway_Homo sapiens_hsa033200.79776142
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79294005
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79026217
66Mismatch repair_Homo sapiens_hsa034300.76545324
67GnRH signaling pathway_Homo sapiens_hsa049120.74984115
68Histidine metabolism_Homo sapiens_hsa003400.74630880
69Bladder cancer_Homo sapiens_hsa052190.73375087
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73190435
71Toxoplasmosis_Homo sapiens_hsa051450.71298020
72Allograft rejection_Homo sapiens_hsa053300.70678684
73Pancreatic cancer_Homo sapiens_hsa052120.70275046
74Autoimmune thyroid disease_Homo sapiens_hsa053200.69524734
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68805403
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68377916
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68242120
78Protein digestion and absorption_Homo sapiens_hsa049740.68186469
79Lysosome_Homo sapiens_hsa041420.67999144
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65653490
81RNA transport_Homo sapiens_hsa030130.65437023
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65236195
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64002210
84Renin-angiotensin system_Homo sapiens_hsa046140.63936467
85Tyrosine metabolism_Homo sapiens_hsa003500.62632266
86Ovarian steroidogenesis_Homo sapiens_hsa049130.62007714
87Influenza A_Homo sapiens_hsa051640.61745234
88Pertussis_Homo sapiens_hsa051330.60005058
89Insulin resistance_Homo sapiens_hsa049310.59881582
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.59251790
91Pancreatic secretion_Homo sapiens_hsa049720.59161014
92DNA replication_Homo sapiens_hsa030300.59143355
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.57032060
94Bile secretion_Homo sapiens_hsa049760.55701262
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54682138
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54599683
97Pyrimidine metabolism_Homo sapiens_hsa002400.53431631
98Regulation of autophagy_Homo sapiens_hsa041400.52931478
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52915864
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.52547028
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51335966
102Fanconi anemia pathway_Homo sapiens_hsa034600.50777682
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50565918
104Small cell lung cancer_Homo sapiens_hsa052220.49586644
105Endocytosis_Homo sapiens_hsa041440.49504498
106Tuberculosis_Homo sapiens_hsa051520.48855476
107Other glycan degradation_Homo sapiens_hsa005110.48780340
108TNF signaling pathway_Homo sapiens_hsa046680.47862788
109Base excision repair_Homo sapiens_hsa034100.47402144
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44645690
111RNA degradation_Homo sapiens_hsa030180.43660544
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43639065
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43318303
114T cell receptor signaling pathway_Homo sapiens_hsa046600.43158469
115HTLV-I infection_Homo sapiens_hsa051660.42757914
116Thyroid cancer_Homo sapiens_hsa052160.42756028
117Glycerolipid metabolism_Homo sapiens_hsa005610.42403245
118One carbon pool by folate_Homo sapiens_hsa006700.42323374
119Homologous recombination_Homo sapiens_hsa034400.42160704
120Leishmaniasis_Homo sapiens_hsa051400.42107528
121Proteoglycans in cancer_Homo sapiens_hsa052050.41824514
122Inositol phosphate metabolism_Homo sapiens_hsa005620.41709253
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.41284397
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40658108
125Chronic myeloid leukemia_Homo sapiens_hsa052200.39977566
126Hepatitis C_Homo sapiens_hsa051600.38946010
127Graft-versus-host disease_Homo sapiens_hsa053320.38704139
128Antigen processing and presentation_Homo sapiens_hsa046120.38447250
129Wnt signaling pathway_Homo sapiens_hsa043100.38147623
130Fatty acid biosynthesis_Homo sapiens_hsa000610.37748759
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37609089
132MicroRNAs in cancer_Homo sapiens_hsa052060.37043976
133Pathways in cancer_Homo sapiens_hsa052000.36159874
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.35945041
135Renin secretion_Homo sapiens_hsa049240.35647785
136Cell cycle_Homo sapiens_hsa041100.35453524
137Endometrial cancer_Homo sapiens_hsa052130.35206948
138Apoptosis_Homo sapiens_hsa042100.34260406
139Non-small cell lung cancer_Homo sapiens_hsa052230.34221585
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34032718
141Spliceosome_Homo sapiens_hsa030400.33300044
142Dorso-ventral axis formation_Homo sapiens_hsa043200.32739556
143Arginine and proline metabolism_Homo sapiens_hsa003300.29368057
144Selenocompound metabolism_Homo sapiens_hsa004500.29023785
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.28711333
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28692643
147Nucleotide excision repair_Homo sapiens_hsa034200.27081843
148Butanoate metabolism_Homo sapiens_hsa006500.26653658
149Phototransduction_Homo sapiens_hsa047440.26052254
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25581432
151Axon guidance_Homo sapiens_hsa043600.25012693
152Vitamin B6 metabolism_Homo sapiens_hsa007500.24942691
153Melanoma_Homo sapiens_hsa052180.24671705
154Prostate cancer_Homo sapiens_hsa052150.23451056
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.22631297
156Basal transcription factors_Homo sapiens_hsa030220.22623808
157Rheumatoid arthritis_Homo sapiens_hsa053230.22193052
158Gastric acid secretion_Homo sapiens_hsa049710.21452060
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.21141507

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