AQP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)5.96789136
2cellular potassium ion homeostasis (GO:0030007)5.70819861
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.62207736
4amino acid import (GO:0043090)5.41421612
5sodium ion export (GO:0071436)5.41034893
6C4-dicarboxylate transport (GO:0015740)5.38134500
7cell communication by electrical coupling (GO:0010644)4.82851917
8alanine transport (GO:0032328)4.75049961
9gamma-aminobutyric acid transport (GO:0015812)4.53424140
10presynaptic membrane assembly (GO:0097105)4.47896950
11cellular sodium ion homeostasis (GO:0006883)4.42166745
12potassium ion import (GO:0010107)4.40125159
13negative regulation of astrocyte differentiation (GO:0048712)4.36066703
14neurotransmitter-gated ion channel clustering (GO:0072578)4.34493016
15presynaptic membrane organization (GO:0097090)4.29286455
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.24508491
17regulation of synaptic vesicle transport (GO:1902803)4.16505265
18locomotory exploration behavior (GO:0035641)4.16467159
19astrocyte differentiation (GO:0048708)4.13887939
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06626463
21neuronal ion channel clustering (GO:0045161)4.05801411
22cerebellar granule cell differentiation (GO:0021707)3.99115097
23potassium ion homeostasis (GO:0055075)3.93956042
24central nervous system myelination (GO:0022010)3.91317790
25axon ensheathment in central nervous system (GO:0032291)3.91317790
26low-density lipoprotein particle remodeling (GO:0034374)3.89496497
27astrocyte development (GO:0014002)3.83195954
28atrial cardiac muscle cell action potential (GO:0086014)3.81826152
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.76142697
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70448912
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65729897
32neurotransmitter uptake (GO:0001504)3.64744826
33L-serine transport (GO:0015825)3.61616384
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.56392481
35positive regulation of synapse maturation (GO:0090129)3.54504073
36negative regulation of sodium ion transport (GO:0010766)3.53587487
37proline transport (GO:0015824)3.52783451
38positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50986637
39glutamate receptor signaling pathway (GO:0007215)3.49372505
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46179520
41response to auditory stimulus (GO:0010996)3.45782235
42membrane repolarization (GO:0086009)3.44016284
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.43605622
44neuromuscular process controlling balance (GO:0050885)3.43580088
45regulation of cardiac muscle cell contraction (GO:0086004)3.36173359
46glutamate secretion (GO:0014047)3.35306257
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29495627
48synaptic transmission, glutamatergic (GO:0035249)3.29481436
49vocalization behavior (GO:0071625)3.26584106
50regulation of neurotransmitter uptake (GO:0051580)3.25493670
51regulation of synaptic plasticity (GO:0048167)3.25101096
52neuronal action potential propagation (GO:0019227)3.21938717
53chondroitin sulfate catabolic process (GO:0030207)3.21443032
54acidic amino acid transport (GO:0015800)3.20366453
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20079602
56regulation of voltage-gated calcium channel activity (GO:1901385)3.19514611
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.15724619
58prepulse inhibition (GO:0060134)3.14279726
59regulation of synapse structural plasticity (GO:0051823)3.12754105
60regulation of beta-amyloid formation (GO:1902003)3.12382206
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12365714
62regulation of neurotransmitter transport (GO:0051588)3.11309075
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.10635836
64regulation of astrocyte differentiation (GO:0048710)3.10617959
65negative regulation of protein localization to cell surface (GO:2000009)3.10431296
66neuron cell-cell adhesion (GO:0007158)3.08909830
67regulation of ARF protein signal transduction (GO:0032012)3.08661984
68mechanosensory behavior (GO:0007638)3.08236283
69positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.07871101
70synaptic vesicle maturation (GO:0016188)3.07842450
71regulation of membrane repolarization (GO:0060306)3.07729076
72membrane assembly (GO:0071709)3.05216352
73myelination (GO:0042552)3.04764378
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.04083261
75glycine transport (GO:0015816)3.03937981
76regulation of neurotransmitter secretion (GO:0046928)3.03933591
77protein localization to synapse (GO:0035418)3.03806547
78adenine nucleotide transport (GO:0051503)3.03285099
79serine transport (GO:0032329)3.02852192
80positive regulation of dendritic spine development (GO:0060999)3.01473936
81ensheathment of neurons (GO:0007272)2.99731480
82axon ensheathment (GO:0008366)2.99731480
83regulation of excitatory postsynaptic membrane potential (GO:0060079)2.99636433
84auditory behavior (GO:0031223)2.99370031
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.98946163
86long-term memory (GO:0007616)2.97880498
87neurotransmitter secretion (GO:0007269)2.96487972
88regulation of neuronal synaptic plasticity (GO:0048168)2.95021128
89positive regulation of membrane potential (GO:0045838)2.94335538
90membrane depolarization during action potential (GO:0086010)2.92578200
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90739315
92myelination in peripheral nervous system (GO:0022011)2.90632563
93peripheral nervous system axon ensheathment (GO:0032292)2.90632563
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90365278
95synaptic vesicle exocytosis (GO:0016079)2.89406590
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88605807
97regulation of synapse maturation (GO:0090128)2.88449569
98cellular response to cholesterol (GO:0071397)2.87356082
99L-glutamate transport (GO:0015813)2.86176872
100positive regulation of potassium ion transport (GO:0043268)2.85640172
101positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84911537
102vascular smooth muscle contraction (GO:0014829)2.84810480
103negative regulation of neurotransmitter transport (GO:0051589)2.84469811
104synaptic vesicle endocytosis (GO:0048488)2.84098695
105regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.83855798
106activation of protein kinase A activity (GO:0034199)2.83496873
107artery smooth muscle contraction (GO:0014824)2.82753998
108negative regulation of glial cell differentiation (GO:0045686)2.81952629
109layer formation in cerebral cortex (GO:0021819)2.81703673
110regulation of female receptivity (GO:0045924)2.81137608
111transmission of nerve impulse (GO:0019226)2.79862027
112regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79146209
113postsynaptic membrane organization (GO:0001941)2.78126302
114neuroblast proliferation (GO:0007405)2.77303370
115regulation of postsynaptic membrane potential (GO:0060078)2.77092139
116regulation of synaptic transmission (GO:0050804)2.75623420
117regulation of respiratory system process (GO:0044065)2.74672802
118myelin maintenance (GO:0043217)2.74576991
119cGMP-mediated signaling (GO:0019934)2.74486547
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74434766
121regulation of synaptic vesicle exocytosis (GO:2000300)2.73521670
122cerebellar Purkinje cell layer development (GO:0021680)2.73386941
123response to gravity (GO:0009629)2.73226471
124neuron-neuron synaptic transmission (GO:0007270)2.72723268
125neurotransmitter transport (GO:0006836)2.72357855
126ovulation cycle (GO:0042698)2.70859990
127sodium ion homeostasis (GO:0055078)2.70463633
128exploration behavior (GO:0035640)2.68341768
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66767951
130regulation of glutamate receptor signaling pathway (GO:1900449)2.65587341
131cell communication involved in cardiac conduction (GO:0086065)2.61384686
132dermatan sulfate metabolic process (GO:0030205)2.60416500
133purine nucleotide transport (GO:0015865)2.59556155
134long-term synaptic potentiation (GO:0060291)2.59366521
135membrane repolarization during action potential (GO:0086011)2.59100300
136long term synaptic depression (GO:0060292)2.58212411
137cell differentiation in hindbrain (GO:0021533)2.56054229
138regulation of neurotransmitter levels (GO:0001505)2.55428690
139cellular response to sterol (GO:0036315)2.51894847
140dermatan sulfate biosynthetic process (GO:0030208)2.50635964
141lateral sprouting from an epithelium (GO:0060601)2.50567015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89220986
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95025619
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76087460
4GBX2_23144817_ChIP-Seq_PC3_Human2.71929016
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54782828
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48361846
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46899008
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46899008
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46423591
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35465928
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34293907
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.33339265
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30753068
14AR_21572438_ChIP-Seq_LNCaP_Human2.28894681
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17583503
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16217142
17DROSHA_22980978_ChIP-Seq_HELA_Human2.11289965
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.07491015
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.01200109
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.00814777
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99104861
22REST_21632747_ChIP-Seq_MESCs_Mouse1.88272273
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81604150
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80467926
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75480237
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74891101
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.72855997
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.63416211
29RXR_22108803_ChIP-Seq_LS180_Human1.48634782
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45265712
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45048365
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.44833632
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.44615219
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43961666
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43901658
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41846051
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41687534
38BCAT_22108803_ChIP-Seq_LS180_Human1.40508194
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.39029788
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38593920
41CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38337407
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.37583279
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.35804889
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.35693228
45SMAD4_21799915_ChIP-Seq_A2780_Human1.34085359
46P300_19829295_ChIP-Seq_ESCs_Human1.32578348
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30817802
48AR_25329375_ChIP-Seq_VCAP_Human1.29603017
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28801860
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28636052
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27036542
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23668858
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20130049
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19436674
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19356019
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19047937
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18026688
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.17894798
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17075729
60KDM2B_26808549_Chip-Seq_K562_Human1.16754781
61TP53_16413492_ChIP-PET_HCT116_Human1.15519993
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14088933
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14070988
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13759540
65AR_19668381_ChIP-Seq_PC3_Human1.13034860
66TP53_18474530_ChIP-ChIP_U2OS_Human1.12781171
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.12477941
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12311512
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12255456
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11999604
71AHR_22903824_ChIP-Seq_MCF-7_Human1.11517009
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10204824
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10204824
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.09418646
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.08572777
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08502404
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07962718
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07116415
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05886083
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05042017
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05021294
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.03011429
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03010041
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02506921
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02379867
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02351952
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02328100
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.01514794
89STAT3_23295773_ChIP-Seq_U87_Human1.01259009
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00371445
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96607098
92* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95524386
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.95153286
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94419268
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94419268
96TAF15_26573619_Chip-Seq_HEK293_Human0.93149766
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92706012
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91723910
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91429582
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.91354626
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91273514
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90963606
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90105902
104EP300_21415370_ChIP-Seq_HL-1_Mouse0.90079694
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.89504732
106RUNX2_22187159_ChIP-Seq_PCA_Human0.89351159
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.88867132
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87624451
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87310368
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86831301
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85809884
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.85803544
113* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85532223
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83393082
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83138186
116TCF4_22108803_ChIP-Seq_LS180_Human0.82257891
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.82166302
118TCF4_23295773_ChIP-Seq_U87_Human0.81691583
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80903698
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78082670
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77125971
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76940856
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75382399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.90301552
2MP0003136_yellow_coat_color3.83973770
3MP0005646_abnormal_pituitary_gland3.27893081
4* MP0003690_abnormal_glial_cell3.13767578
5MP0003635_abnormal_synaptic_transmissio2.85414968
6MP0009780_abnormal_chondrocyte_physiolo2.75573571
7MP0009046_muscle_twitch2.73282773
8MP0004885_abnormal_endolymph2.69642989
9MP0004858_abnormal_nervous_system2.67415831
10MP0004270_analgesia2.62156241
11MP0005423_abnormal_somatic_nervous2.50723766
12MP0001984_abnormal_olfaction2.44327325
13MP0001486_abnormal_startle_reflex2.43354916
14* MP0009745_abnormal_behavioral_response2.34401148
15MP0003329_amyloid_beta_deposits2.29105037
16MP0002822_catalepsy2.27928562
17MP0002064_seizures2.27102581
18MP0002063_abnormal_learning/memory/cond2.16663489
19MP0004043_abnormal_pH_regulation2.16171298
20MP0003880_abnormal_central_pattern2.08304485
21MP0001440_abnormal_grooming_behavior2.04707514
22MP0009384_cardiac_valve_regurgitation2.01756481
23MP0002572_abnormal_emotion/affect_behav1.97944608
24MP0003879_abnormal_hair_cell1.96248033
25MP0008569_lethality_at_weaning1.94758468
26MP0005670_abnormal_white_adipose1.92306426
27MP0002734_abnormal_mechanical_nocicepti1.91917022
28MP0002272_abnormal_nervous_system1.91780080
29MP0005171_absent_coat_pigmentation1.90816948
30MP0001485_abnormal_pinna_reflex1.86601776
31MP0001502_abnormal_circadian_rhythm1.76387463
32MP0005167_abnormal_blood-brain_barrier1.76289302
33MP0001501_abnormal_sleep_pattern1.73067606
34MP0003634_abnormal_glial_cell1.70590756
35* MP0003633_abnormal_nervous_system1.69154667
36MP0005394_taste/olfaction_phenotype1.67657385
37MP0005499_abnormal_olfactory_system1.67657385
38MP0005645_abnormal_hypothalamus_physiol1.61854446
39MP0001968_abnormal_touch/_nociception1.60424272
40MP0002067_abnormal_sensory_capabilities1.58773390
41MP0002254_reproductive_system_inflammat1.56721447
42MP0000778_abnormal_nervous_system1.54167198
43MP0002909_abnormal_adrenal_gland1.50800535
44MP0005386_behavior/neurological_phenoty1.44237935
45MP0004924_abnormal_behavior1.44237935
46MP0002557_abnormal_social/conspecific_i1.44149078
47MP0002736_abnormal_nociception_after1.41686127
48MP0008789_abnormal_olfactory_epithelium1.39881930
49MP0002733_abnormal_thermal_nociception1.33458155
50MP0000049_abnormal_middle_ear1.32006227
51MP0003279_aneurysm1.31647582
52* MP0003631_nervous_system_phenotype1.30707951
53MP0004742_abnormal_vestibular_system1.27929252
54MP0004142_abnormal_muscle_tone1.27460252
55MP0001970_abnormal_pain_threshold1.26858913
56MP0001986_abnormal_taste_sensitivity1.24358087
57MP0002089_abnormal_postnatal_growth/wei1.22040077
58MP0002882_abnormal_neuron_morphology1.16125312
59MP0006276_abnormal_autonomic_nervous1.14186211
60MP0000955_abnormal_spinal_cord1.13745411
61MP0000566_synostosis1.12957077
62MP0000920_abnormal_myelination1.12498248
63MP0003632_abnormal_nervous_system1.11285680
64MP0000604_amyloidosis1.09723118
65MP0001958_emphysema1.09675035
66MP0003137_abnormal_impulse_conducting1.08925491
67* MP0001963_abnormal_hearing_physiology1.08799814
68MP0002638_abnormal_pupillary_reflex1.08726651
69* MP0005551_abnormal_eye_electrophysiolog1.08340389
70MP0004215_abnormal_myocardial_fiber1.06546197
71MP0002735_abnormal_chemical_nociception1.02464612
72MP0002066_abnormal_motor_capabilities/c1.02061410
73MP0004130_abnormal_muscle_cell1.00976862
74MP0000026_abnormal_inner_ear0.99988944
75MP0003011_delayed_dark_adaptation0.98876873
76MP0003878_abnormal_ear_physiology0.98514881
77MP0005377_hearing/vestibular/ear_phenot0.98514881
78MP0002653_abnormal_ependyma_morphology0.97813048
79* MP0003075_altered_response_to0.95392446
80MP0002090_abnormal_vision0.95299728
81MP0002152_abnormal_brain_morphology0.94457713
82MP0000631_abnormal_neuroendocrine_gland0.94418613
83* MP0001905_abnormal_dopamine_level0.94114706
84MP0003938_abnormal_ear_development0.92741912
85MP0005388_respiratory_system_phenotype0.90587077
86MP0002133_abnormal_respiratory_system0.90587077
87MP0002229_neurodegeneration0.89668410
88MP0001299_abnormal_eye_distance/0.86781273
89MP0008874_decreased_physiological_sensi0.86162734
90MP0002184_abnormal_innervation0.84682212
91MP0009379_abnormal_foot_pigmentation0.81251753
92MP0006072_abnormal_retinal_apoptosis0.80041760
93MP0000747_muscle_weakness0.75386393
94MP0003787_abnormal_imprinting0.74485085
95MP0004147_increased_porphyrin_level0.73964288
96MP0005409_darkened_coat_color0.73903949
97* MP0005253_abnormal_eye_physiology0.71695277
98MP0001177_atelectasis0.71435262
99MP0000751_myopathy0.71301326
100MP0005332_abnormal_amino_acid0.69412904
101MP0005595_abnormal_vascular_smooth0.69347884
102MP0004811_abnormal_neuron_physiology0.67248538
103MP0002752_abnormal_somatic_nervous0.66366912
104MP0005535_abnormal_body_temperature0.66192219
105MP0008872_abnormal_physiological_respon0.65880696
106MP0004134_abnormal_chest_morphology0.65828109
107MP0000749_muscle_degeneration0.65089996
108MP0000428_abnormal_craniofacial_morphol0.64853446
109MP0004782_abnormal_surfactant_physiolog0.63623282
110MP0002069_abnormal_eating/drinking_beha0.63578852
111MP0002332_abnormal_exercise_endurance0.63026732
112MP0001346_abnormal_lacrimal_gland0.61366450
113MP0001943_abnormal_respiration0.60938404
114MP0002233_abnormal_nose_morphology0.60363895
115MP0001529_abnormal_vocalization0.60224511
116MP0001270_distended_abdomen0.59567652
117MP0000579_abnormal_nail_morphology0.57803719
118MP0005165_increased_susceptibility_to0.56796212
119MP0002249_abnormal_larynx_morphology0.55403667
120MP0004036_abnormal_muscle_relaxation0.54899213
121MP0000569_abnormal_digit_pigmentation0.54733285
122MP0010769_abnormal_survival0.51496045
123MP0003045_fibrosis0.50069888
124MP0000462_abnormal_digestive_system0.49502248
125MP0010768_mortality/aging0.47721768
126MP0005623_abnormal_meninges_morphology0.47612737
127MP0004085_abnormal_heartbeat0.46967237
128MP0002082_postnatal_lethality0.46100286
129MP0010770_preweaning_lethality0.46100286

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)6.43185107
2Aplasia involving bones of the upper limbs (HP:0009823)6.43185107
3Aplasia of the phalanges of the hand (HP:0009802)6.43185107
4Focal motor seizures (HP:0011153)4.75772814
5Megalencephaly (HP:0001355)4.41966644
6Synostosis involving the elbow (HP:0003938)4.24120485
7Humeroradial synostosis (HP:0003041)4.24120485
8Atonic seizures (HP:0010819)3.98185137
9Hemiparesis (HP:0001269)3.94697382
10Ankle clonus (HP:0011448)3.93951777
11Abnormality of binocular vision (HP:0011514)3.89640117
12Diplopia (HP:0000651)3.89640117
13Obstructive sleep apnea (HP:0002870)3.69934163
14Abnormality of the middle phalanges of the toes (HP:0010183)3.43297580
15Hemiplegia (HP:0002301)3.41889529
16Potter facies (HP:0002009)3.34115337
17Facial shape deformation (HP:0011334)3.34115337
18Spastic gait (HP:0002064)3.27067668
19Myokymia (HP:0002411)3.26507968
20Long nose (HP:0003189)3.22933691
21Short hallux (HP:0010109)3.19725742
22Neurofibrillary tangles (HP:0002185)3.16600188
23Hypoplastic left heart (HP:0004383)3.15289095
24Progressive cerebellar ataxia (HP:0002073)3.13913751
25Alopecia of scalp (HP:0002293)3.12075590
26Action tremor (HP:0002345)3.07576009
27Epileptic encephalopathy (HP:0200134)3.06567781
28Focal seizures (HP:0007359)3.01955898
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.96488353
30Papilledema (HP:0001085)2.93759988
31Aplasia/Hypoplasia of the hallux (HP:0008362)2.88038264
32Mixed hearing impairment (HP:0000410)2.78824950
33Mutism (HP:0002300)2.78436183
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.69097627
35Abnormality of the phalanges of the 5th finger (HP:0004213)2.68981335
36Short middle phalanx of the 5th finger (HP:0004220)2.67916834
37Urinary bladder sphincter dysfunction (HP:0002839)2.67015979
38Visual hallucinations (HP:0002367)2.64774685
39Insomnia (HP:0100785)2.63025821
40Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.61630772
41Dysdiadochokinesis (HP:0002075)2.60073523
42Akinesia (HP:0002304)2.58217902
43Metabolic alkalosis (HP:0200114)2.55771585
44Lower limb muscle weakness (HP:0007340)2.53254133
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.51802344
46Torticollis (HP:0000473)2.51715175
47Neuronal loss in central nervous system (HP:0002529)2.51083493
48Abnormality of the corticospinal tract (HP:0002492)2.49881531
49Follicular hyperkeratosis (HP:0007502)2.49043348
50Bronchomalacia (HP:0002780)2.47831326
51Abnormal ciliary motility (HP:0012262)2.45193459
52Abnormal respiratory motile cilium physiology (HP:0012261)2.43626522
53Increased circulating renin level (HP:0000848)2.41924526
54Hyporeflexia of lower limbs (HP:0002600)2.41539364
55Fibular aplasia (HP:0002990)2.40411324
56Generalized tonic-clonic seizures (HP:0002069)2.40157378
57Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.39288667
58Anxiety (HP:0000739)2.37077149
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.36760491
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36760491
61Split foot (HP:0001839)2.36751643
62Sleep apnea (HP:0010535)2.36193075
63Bundle branch block (HP:0011710)2.35807329
64Rapidly progressive (HP:0003678)2.34974256
65Cerebral inclusion bodies (HP:0100314)2.34708189
66Abnormal eating behavior (HP:0100738)2.33950659
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33265510
68Supranuclear gaze palsy (HP:0000605)2.32987899
69Limb dystonia (HP:0002451)2.31255582
70Rigidity (HP:0002063)2.30930754
71Cerebral hypomyelination (HP:0006808)2.30854761
72Urinary urgency (HP:0000012)2.30240592
73Hypoplastic heart (HP:0001961)2.29782138
74Narrow nasal bridge (HP:0000446)2.28973755
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.28798714
76Confusion (HP:0001289)2.27837258
77Abnormality of the nasal septum (HP:0000419)2.25289804
78Poor eye contact (HP:0000817)2.24914048
79Bradykinesia (HP:0002067)2.24511108
80Intention tremor (HP:0002080)2.24178816
81Fetal akinesia sequence (HP:0001989)2.23754244
82Abnormality of the dental pulp (HP:0006479)2.23716699
83Status epilepticus (HP:0002133)2.21757394
84Abnormal urine output (HP:0012590)2.21255330
85Abnormal drinking behavior (HP:0030082)2.20510260
86Polydipsia (HP:0001959)2.20510260
87Alacrima (HP:0000522)2.19804992
88Dialeptic seizures (HP:0011146)2.13765086
89Abnormality of secondary sexual hair (HP:0009888)2.12153407
90Abnormality of the axillary hair (HP:0100134)2.12153407
91Annular pancreas (HP:0001734)2.09607292
92Impaired vibration sensation in the lower limbs (HP:0002166)2.09096382
93Turricephaly (HP:0000262)2.08810407
94Spastic tetraparesis (HP:0001285)2.08802628
95Postural instability (HP:0002172)2.08187041
96Clonus (HP:0002169)2.07892869
97Thickened helices (HP:0000391)2.07066136
98Scanning speech (HP:0002168)2.05975286
99Hyperventilation (HP:0002883)2.05659927
100Abnormality of permanent molar morphology (HP:0011071)2.05339812
101Abnormality of the dental root (HP:0006486)2.05339812
102Taurodontia (HP:0000679)2.05339812
103Foot dorsiflexor weakness (HP:0009027)2.04104847
104Abnormality of the periventricular white matter (HP:0002518)2.03864815
105Truncal ataxia (HP:0002078)2.02141396
106Median cleft lip (HP:0000161)2.02114835
107Anomalous pulmonary venous return (HP:0010772)2.01419237
108Abnormality of renal excretion (HP:0011036)2.01380074
109Epileptiform EEG discharges (HP:0011182)1.99528888
110Pheochromocytoma (HP:0002666)1.99340890
111Cutaneous syndactyly (HP:0012725)1.99196122
112Abnormal social behavior (HP:0012433)1.97693826
113Impaired social interactions (HP:0000735)1.97693826
114Bowel incontinence (HP:0002607)1.94746795
115Heart block (HP:0012722)1.94566402
116Apathy (HP:0000741)1.92591060
117Abnormality of chromosome segregation (HP:0002916)1.92546895
118Abnormality of the foot musculature (HP:0001436)1.91197078
119Neuroendocrine neoplasm (HP:0100634)1.91103328
120Clumsiness (HP:0002312)1.91072120
121Choreoathetosis (HP:0001266)1.90659613
122Muscle fiber splitting (HP:0003555)1.90396095
123Abnormality of molar morphology (HP:0011070)1.90065515
124Abnormality of molar (HP:0011077)1.90065515
125Stereotypic behavior (HP:0000733)1.89590458
126Atrioventricular block (HP:0001678)1.89554866
127Focal dystonia (HP:0004373)1.89141966
128Abnormality of the middle phalanges of the hand (HP:0009833)1.89101657
129Overriding aorta (HP:0002623)1.88910212
130Paraparesis (HP:0002385)1.88906623
131Delusions (HP:0000746)1.88625879
132Peripheral hypomyelination (HP:0007182)1.88215103
133Postural tremor (HP:0002174)1.88194768
134Absence seizures (HP:0002121)1.88071701
135Morphological abnormality of the middle ear (HP:0008609)1.87735629
136Craniofacial dystonia (HP:0012179)1.81847556
137Hypokalemic alkalosis (HP:0001949)1.81697905
138Increased CSF protein (HP:0002922)1.81062770
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80942110
140Tetraparesis (HP:0002273)1.80296763
141Tetraplegia (HP:0002445)1.79875471
142Abnormality of the pulmonary veins (HP:0011718)1.78514725
143Polyuria (HP:0000103)1.76304347
144Dysmetria (HP:0001310)1.76232211
145Hammertoe (HP:0001765)1.75722511
146Myotonia (HP:0002486)1.75622954
147Abnormal atrioventricular conduction (HP:0005150)1.75264156
148Abnormal large intestine physiology (HP:0012700)1.74365610
149Maternal diabetes (HP:0009800)1.73806735
150Blue irides (HP:0000635)1.72524379
151Aqueductal stenosis (HP:0002410)1.72316526
152Abnormality of cochlea (HP:0000375)1.71773891
153Morphological abnormality of the inner ear (HP:0011390)1.70538263
154Depression (HP:0000716)1.69371342
155Tarsal synostosis (HP:0008368)1.67797069
156Renal tubular acidosis (HP:0001947)1.67483220
157Absent/shortened dynein arms (HP:0200106)1.67302105
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.67302105
159Febrile seizures (HP:0002373)1.67226392
160Gaze-evoked nystagmus (HP:0000640)1.66600368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.28116809
2TNIK3.42018803
3NTRK23.24143840
4PHKG22.84903346
5PHKG12.84903346
6NTRK32.70774888
7EPHA42.62590809
8CASK2.31116678
9PRKD32.30122331
10MARK12.06971035
11SGK21.92474746
12PINK11.87321387
13MINK11.84914292
14SGK4941.80284188
15SGK2231.80284188
16MAP2K71.77444726
17MAP3K41.70564335
18SGK31.52402960
19PAK61.49609458
20NEK61.48692579
21KSR21.42382817
22MAP3K91.41512681
23MAPK131.34797478
24WNK11.32965371
25PRKCG1.31795087
26CAMKK11.31535854
27MUSK1.31146068
28PAK31.21233421
29MAPK121.19802109
30STK381.19722953
31CDK51.18809377
32MAP3K131.17589064
33CDC42BPA1.16844992
34DAPK21.16696415
35LATS21.16608692
36ROCK21.15887204
37NTRK11.15124506
38MAP2K41.08142838
39OXSR11.04103122
40ARAF1.03830593
41FGFR21.03451968
42PRKCE1.01212428
43RIPK10.96214542
44MARK20.96188754
45MST40.94366939
46SIK10.94030567
47CAMK2G0.92870467
48SGK10.92596024
49MAP3K20.92511920
50CAMK2A0.91946936
51ROCK10.90814956
52INSRR0.90764197
53CAMKK20.88394147
54ERBB30.86977343
55PDGFRA0.86118386
56MAPK70.85792720
57TYRO30.84933830
58CAMK2B0.84415933
59PRKCH0.81814226
60TNK20.79951806
61PIK3CA0.77042268
62RET0.75851786
63CAMK2D0.74093781
64TRIB30.73081036
65DYRK1A0.71995338
66FES0.70617896
67STK240.70554284
68ERBB40.67326832
69MAP3K70.66912574
70PLK20.66876900
71CDK180.65878185
72ERBB20.65070396
73MAPK150.64391503
74STK38L0.63124956
75CSNK1A10.62394126
76BMX0.60712788
77CDK11A0.60507516
78GRK50.59414576
79CDK140.58959040
80PDGFRB0.58934846
81DAPK10.58881501
82MAPKAPK50.58584806
83PRKG10.57857276
84DMPK0.56813089
85WNK30.56434723
86CAMK40.55531362
87MAP3K120.55389962
88JAK20.55118123
89ADRBK10.55001626
90PDPK10.54731635
91PRPF4B0.53268975
92* PRKCA0.52564081
93JAK10.52403461
94UHMK10.52119431
95CSNK1G20.51868622
96MAPK40.51699537
97STK390.51232595
98PRKD10.50867399
99FGFR30.50678227
100MAPK100.50542997
101KSR10.50434398
102OBSCN0.49765232
103CCNB10.49100107
104RPS6KA30.49055161
105PRKACA0.48540488
106ALK0.47380327
107FGFR10.47038154
108PRKACG0.46065568
109CAMK10.45363800
110STK110.44767445
111SIK20.44620466
112RAF10.44138034
113CDK190.44057923
114FYN0.43815304
115IGF1R0.43498870
116SRC0.43403025
117PTK60.42856646
118RIPK40.42486012
119FER0.42405887
120FGR0.42306314
121PDK10.42075711
122PRKCZ0.41545957
123CDK150.40796738
124PKN10.40164245
125PNCK0.39383235
126BMPR20.34861100
127LIMK10.34581129
128CSNK1D0.34435506
129MAP2K10.34063341
130RPS6KB10.33295620

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.69512882
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.77971131
3Nicotine addiction_Homo sapiens_hsa050333.04507205
4Fatty acid biosynthesis_Homo sapiens_hsa000612.61323592
5GABAergic synapse_Homo sapiens_hsa047272.36593967
6Salivary secretion_Homo sapiens_hsa049702.19481961
7Glutamatergic synapse_Homo sapiens_hsa047242.17169856
8Gastric acid secretion_Homo sapiens_hsa049712.11995829
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82575806
10Circadian entrainment_Homo sapiens_hsa047131.80816782
11Insulin secretion_Homo sapiens_hsa049111.77347781
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67492780
13Morphine addiction_Homo sapiens_hsa050321.66207485
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50212193
15Long-term potentiation_Homo sapiens_hsa047201.44211200
16Olfactory transduction_Homo sapiens_hsa047401.43607779
17Amphetamine addiction_Homo sapiens_hsa050311.42410880
18* Bile secretion_Homo sapiens_hsa049761.42102766
19Histidine metabolism_Homo sapiens_hsa003401.33465883
20Vitamin B6 metabolism_Homo sapiens_hsa007501.33222487
21Pancreatic secretion_Homo sapiens_hsa049721.32757307
22Synaptic vesicle cycle_Homo sapiens_hsa047211.31705192
23Taste transduction_Homo sapiens_hsa047421.31608218
24Renin secretion_Homo sapiens_hsa049241.26526529
25Mineral absorption_Homo sapiens_hsa049781.22341724
26Calcium signaling pathway_Homo sapiens_hsa040201.19034951
27Cocaine addiction_Homo sapiens_hsa050301.17682837
28Fatty acid metabolism_Homo sapiens_hsa012121.17591391
29Prion diseases_Homo sapiens_hsa050201.16683500
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16503598
31cAMP signaling pathway_Homo sapiens_hsa040241.14183109
32Long-term depression_Homo sapiens_hsa047301.11704288
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10707316
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09331786
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08596608
36Thyroid hormone synthesis_Homo sapiens_hsa049181.04175332
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02661331
38Cholinergic synapse_Homo sapiens_hsa047250.99993843
39Circadian rhythm_Homo sapiens_hsa047100.99954647
40Fatty acid degradation_Homo sapiens_hsa000710.99368922
41Dopaminergic synapse_Homo sapiens_hsa047280.96844080
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95547468
43PPAR signaling pathway_Homo sapiens_hsa033200.94991117
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93203195
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91745771
46Dorso-ventral axis formation_Homo sapiens_hsa043200.90803403
47Gap junction_Homo sapiens_hsa045400.88532222
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88303025
49beta-Alanine metabolism_Homo sapiens_hsa004100.88188283
50Sulfur metabolism_Homo sapiens_hsa009200.87904915
51Butanoate metabolism_Homo sapiens_hsa006500.87107127
52Melanogenesis_Homo sapiens_hsa049160.82293718
53Cardiac muscle contraction_Homo sapiens_hsa042600.78365801
54Serotonergic synapse_Homo sapiens_hsa047260.77157764
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76522789
56GnRH signaling pathway_Homo sapiens_hsa049120.76014772
57Oxytocin signaling pathway_Homo sapiens_hsa049210.75459117
58* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75343168
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73723375
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.72599039
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71535694
62Dilated cardiomyopathy_Homo sapiens_hsa054140.71374743
63Ras signaling pathway_Homo sapiens_hsa040140.70395053
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69920387
65Inositol phosphate metabolism_Homo sapiens_hsa005620.69341962
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.68610982
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67553603
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66420756
69Arginine biosynthesis_Homo sapiens_hsa002200.65498021
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64290117
71Estrogen signaling pathway_Homo sapiens_hsa049150.63944050
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63457354
73VEGF signaling pathway_Homo sapiens_hsa043700.61697616
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59490227
75Oocyte meiosis_Homo sapiens_hsa041140.59392382
76Propanoate metabolism_Homo sapiens_hsa006400.58872313
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58830561
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58098182
79Type II diabetes mellitus_Homo sapiens_hsa049300.58051416
80Vibrio cholerae infection_Homo sapiens_hsa051100.57851316
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56256833
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55588515
83Endometrial cancer_Homo sapiens_hsa052130.54697324
84Chemical carcinogenesis_Homo sapiens_hsa052040.53920848
85Axon guidance_Homo sapiens_hsa043600.53905561
86Endocytosis_Homo sapiens_hsa041440.53341398
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.53310856
88Steroid biosynthesis_Homo sapiens_hsa001000.52434420
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51886763
90Arginine and proline metabolism_Homo sapiens_hsa003300.51346718
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49921614
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.49135267
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.48823209
94Tight junction_Homo sapiens_hsa045300.47462532
95Choline metabolism in cancer_Homo sapiens_hsa052310.47360480
96Collecting duct acid secretion_Homo sapiens_hsa049660.45150275
97Rap1 signaling pathway_Homo sapiens_hsa040150.42899694
98Ether lipid metabolism_Homo sapiens_hsa005650.40371871
99Fructose and mannose metabolism_Homo sapiens_hsa000510.40256928
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39031064
101Renal cell carcinoma_Homo sapiens_hsa052110.38695083
102mTOR signaling pathway_Homo sapiens_hsa041500.37975687
103ABC transporters_Homo sapiens_hsa020100.37680510
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36129725
105Glucagon signaling pathway_Homo sapiens_hsa049220.35379641
106Starch and sucrose metabolism_Homo sapiens_hsa005000.34875081
107African trypanosomiasis_Homo sapiens_hsa051430.34577450
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34056814
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33732505
110Insulin signaling pathway_Homo sapiens_hsa049100.32478822
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31986965
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31965530
113Peroxisome_Homo sapiens_hsa041460.31829322
114Glioma_Homo sapiens_hsa052140.31312148
115Glycerolipid metabolism_Homo sapiens_hsa005610.31170972
116Ovarian steroidogenesis_Homo sapiens_hsa049130.31157015
117MAPK signaling pathway_Homo sapiens_hsa040100.31022841
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30967430
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.29950493
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29024960
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28814535
122Hippo signaling pathway_Homo sapiens_hsa043900.28662137
123ErbB signaling pathway_Homo sapiens_hsa040120.28327777
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27868829
125AMPK signaling pathway_Homo sapiens_hsa041520.27793364
126Wnt signaling pathway_Homo sapiens_hsa043100.25040441
127Non-small cell lung cancer_Homo sapiens_hsa052230.22069604

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »