AQP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)6.25451425
2regulation of sequestering of triglyceride (GO:0010889)5.86512678
3fatty acid homeostasis (GO:0055089)5.84330639
4diacylglycerol metabolic process (GO:0046339)5.48621766
5central nervous system myelination (GO:0022010)5.45070672
6axon ensheathment in central nervous system (GO:0032291)5.45070672
7transcytosis (GO:0045056)5.09821268
8ethanol oxidation (GO:0006069)4.88581371
9positive regulation of lipid storage (GO:0010884)4.57522555
10regulation of cholesterol storage (GO:0010885)4.54613719
11plasma lipoprotein particle clearance (GO:0034381)4.39256769
12fatty acid transmembrane transport (GO:1902001)4.15612675
13oxaloacetate metabolic process (GO:0006107)4.12004212
14low-density lipoprotein particle clearance (GO:0034383)4.09327954
15cellular response to epinephrine stimulus (GO:0071872)4.08801821
16triglyceride metabolic process (GO:0006641)4.04526566
17brown fat cell differentiation (GO:0050873)4.03922879
18carnitine shuttle (GO:0006853)4.02604854
19regulation of glycogen (starch) synthase activity (GO:2000465)3.94280370
20response to dietary excess (GO:0002021)3.93891633
21acrosome reaction (GO:0007340)3.91639265
22biotin metabolic process (GO:0006768)3.89572390
23retina vasculature morphogenesis in camera-type eye (GO:0061299)3.86134108
24import into cell (GO:0098657)3.83670972
25response to epinephrine (GO:0071871)3.83551986
26ethanol metabolic process (GO:0006067)3.83340564
27cGMP-mediated signaling (GO:0019934)3.82664224
28protein heterotrimerization (GO:0070208)3.82373485
29carnitine transmembrane transport (GO:1902603)3.81168955
30acylglycerol metabolic process (GO:0006639)3.76009386
31glycerol metabolic process (GO:0006071)3.74118918
32regulation of cAMP-dependent protein kinase activity (GO:2000479)3.71262922
33neutral lipid metabolic process (GO:0006638)3.70409489
34positive regulation of glycolytic process (GO:0045821)3.69068309
35negative regulation of granulocyte differentiation (GO:0030853)3.68723741
36positive regulation of glomerulus development (GO:0090193)3.66144454
37regulation of triglyceride catabolic process (GO:0010896)3.65614194
38negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.65188817
39carnitine transport (GO:0015879)3.64512985
40amino-acid betaine transport (GO:0015838)3.64512985
41positive regulation of lipoprotein lipase activity (GO:0051006)3.63972082
42positive regulation of triglyceride lipase activity (GO:0061365)3.63972082
43triglyceride homeostasis (GO:0070328)3.63082609
44acylglycerol homeostasis (GO:0055090)3.63082609
45CDP-diacylglycerol biosynthetic process (GO:0016024)3.58268289
46response to phenylpropanoid (GO:0080184)3.57565367
47regulation of lipoprotein metabolic process (GO:0050746)3.54966874
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.54290230
49regulation of macrophage derived foam cell differentiation (GO:0010743)3.53969989
50sperm capacitation (GO:0048240)3.52986995
51white fat cell differentiation (GO:0050872)3.52199915
52positive regulation of oligodendrocyte differentiation (GO:0048714)3.51102777
53sperm motility (GO:0030317)3.50976507
54triglyceride catabolic process (GO:0019433)3.50030445
55primary alcohol metabolic process (GO:0034308)3.49597220
56multicellular organism reproduction (GO:0032504)3.48357049
57positive regulation of cholesterol efflux (GO:0010875)3.47577760
58CDP-diacylglycerol metabolic process (GO:0046341)3.41817408
59positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.37940836
60triglyceride biosynthetic process (GO:0019432)3.36908816
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35659754
62limb bud formation (GO:0060174)3.35219252
63lipid particle organization (GO:0034389)3.34411474
64axonemal dynein complex assembly (GO:0070286)3.33995665
65negative regulation of execution phase of apoptosis (GO:1900118)3.33977463
66regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.32020137
67detection of calcium ion (GO:0005513)3.31928714
68tricarboxylic acid metabolic process (GO:0072350)3.30554700
69neutral lipid biosynthetic process (GO:0046460)3.29281756
70acylglycerol biosynthetic process (GO:0046463)3.29281756
71long-chain fatty acid biosynthetic process (GO:0042759)3.29088946
72phospholipid homeostasis (GO:0055091)3.27723156
73fatty acid beta-oxidation (GO:0006635)3.27131107
74fusion of sperm to egg plasma membrane (GO:0007342)3.26189054
75alpha-linolenic acid metabolic process (GO:0036109)3.23376225
76regulation of lipid storage (GO:0010883)3.20578423
77negative regulation of protein localization to cell surface (GO:2000009)3.18990784
78alditol metabolic process (GO:0019400)3.17422913
79positive regulation of fatty acid metabolic process (GO:0045923)3.16483889
80creatine metabolic process (GO:0006600)3.15414532
81positive regulation of glucose import (GO:0046326)3.14981973
82negative regulation of macrophage differentiation (GO:0045650)3.14910369
83lipid storage (GO:0019915)3.14565927
84motile cilium assembly (GO:0044458)3.13744135
85epithelial cilium movement (GO:0003351)3.12383522
86retinol metabolic process (GO:0042572)3.09478839
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08790916
88glycerolipid catabolic process (GO:0046503)3.06720859
89positive regulation of cholesterol transport (GO:0032376)3.05998182
90positive regulation of sterol transport (GO:0032373)3.05998182
91valine metabolic process (GO:0006573)3.05016736
92presynaptic membrane assembly (GO:0097105)3.02890053
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98205494
94long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.95014376
95fatty-acyl-CoA metabolic process (GO:0035337)2.94464496
96myelination (GO:0042552)2.92599434
97regulation of gonadotropin secretion (GO:0032276)2.91915053
98positive regulation of fatty acid oxidation (GO:0046321)2.89585506
99cell wall macromolecule catabolic process (GO:0016998)2.89513979
100cell wall macromolecule metabolic process (GO:0044036)2.89513979
101ensheathment of neurons (GO:0007272)2.87964864
102axon ensheathment (GO:0008366)2.87964864
103negative regulation of gluconeogenesis (GO:0045721)2.86666152
104negative regulation of Rho protein signal transduction (GO:0035024)2.84960601
105presynaptic membrane organization (GO:0097090)2.84762221
106acyl-CoA metabolic process (GO:0006637)2.84657815
107thioester metabolic process (GO:0035383)2.84657815
108acylglycerol catabolic process (GO:0046464)2.84163715
109neutral lipid catabolic process (GO:0046461)2.84163715
110negative regulation of metanephros development (GO:0072217)2.83370526
111cyclic nucleotide catabolic process (GO:0009214)2.82387077
112glycerophospholipid catabolic process (GO:0046475)2.81673021
113positive regulation of protein kinase C signaling (GO:0090037)2.81387571
114fatty acid catabolic process (GO:0009062)2.80942903
115quaternary ammonium group transport (GO:0015697)2.80650671
116regulation of fatty acid oxidation (GO:0046320)2.80309401
117negative regulation of smooth muscle cell migration (GO:0014912)2.78839410
118cilium or flagellum-dependent cell motility (GO:0001539)2.78512546
119acetyl-CoA metabolic process (GO:0006084)2.77409820
120positive regulation of lipid catabolic process (GO:0050996)2.77068086
121phosphatidic acid metabolic process (GO:0046473)2.76838730
122phosphatidic acid biosynthetic process (GO:0006654)2.76838730
123long-chain fatty acid transport (GO:0015909)2.73952602
124ovulation from ovarian follicle (GO:0001542)2.72547487
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.72314712
126neuron remodeling (GO:0016322)2.70834021
127response to monoamine (GO:0071867)2.70103424
128response to catecholamine (GO:0071869)2.70103424
129cellular response to catecholamine stimulus (GO:0071870)2.69716432
130cellular response to monoamine stimulus (GO:0071868)2.69716432
131glycine transport (GO:0015816)2.68005615
132cilium movement (GO:0003341)2.67651617
133long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.66919288
134adult feeding behavior (GO:0008343)2.66296269
135regulation of pigment cell differentiation (GO:0050932)2.66232679
136retina layer formation (GO:0010842)2.66208447
137positive regulation of action potential (GO:0045760)2.65324091
138fatty acid oxidation (GO:0019395)2.64440681
139negative regulation of protein autophosphorylation (GO:0031953)2.63469146
140branched-chain amino acid catabolic process (GO:0009083)2.63363561
141response to lipoprotein particle (GO:0055094)2.62336789
142organic cation transport (GO:0015695)2.61512615
143lipid oxidation (GO:0034440)2.60827014
144plasma membrane fusion (GO:0045026)2.58521638
145membrane assembly (GO:0071709)2.57557782
146thioester biosynthetic process (GO:0035384)2.56124258
147acyl-CoA biosynthetic process (GO:0071616)2.56124258
148regulation of somitogenesis (GO:0014807)2.55927505
149fatty acid elongation (GO:0030497)2.55685929
150reproduction (GO:0000003)2.55506898
151acrosome assembly (GO:0001675)2.54798818
152negative regulation of response to food (GO:0032096)2.53659146
153negative regulation of appetite (GO:0032099)2.53659146
154adrenergic receptor signaling pathway (GO:0071875)2.53463128
155positive regulation of smooth muscle cell migration (GO:0014911)2.51175265
156glomerular filtration (GO:0003094)2.50055073
157negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48351616
158cAMP catabolic process (GO:0006198)2.48011708
159respiratory electron transport chain (GO:0022904)2.47906483
160regulation of glomerulus development (GO:0090192)2.45953833
161mesonephros development (GO:0001823)2.45709157
162* polyol transport (GO:0015791)2.43099663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.54009545
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44876835
3GBX2_23144817_ChIP-Seq_PC3_Human3.41864865
4EZH2_22144423_ChIP-Seq_EOC_Human3.38865166
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89466040
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87607696
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.79890251
8CLOCK_20551151_ChIP-Seq_293T_Human2.73053986
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.60076305
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54092981
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49943632
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.47860805
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33714271
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23052688
15VDR_22108803_ChIP-Seq_LS180_Human2.22881603
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18888778
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15650682
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.10453706
19TBX20_22328084_ChIP-Seq_HEART_Mouse2.06842325
20TBX20_22080862_ChIP-Seq_HEART_Mouse2.06842325
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.98767631
22TAF15_26573619_Chip-Seq_HEK293_Human1.97366253
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94364076
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89708005
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.89415905
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88684237
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.84071031
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76746365
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75208851
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75146366
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75023228
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74330646
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74252350
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74073441
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73052688
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73037017
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72918267
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70016096
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69461219
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69461219
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69436246
42ER_23166858_ChIP-Seq_MCF-7_Human1.67858359
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67193349
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65051677
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.62324628
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61498590
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59082502
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56219468
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55798859
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55710373
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.55597219
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54697926
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.53650674
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52581171
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51945564
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49646291
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.49636852
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49137979
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.47887728
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.47165608
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45425069
62P300_19829295_ChIP-Seq_ESCs_Human1.44731150
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44341401
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43056232
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43054075
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.42939426
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42930537
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.40793906
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40721104
70GATA1_22025678_ChIP-Seq_K562_Human1.39314539
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38937020
72P300_18555785_Chip-Seq_ESCs_Mouse1.37719911
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.37707979
74P53_22387025_ChIP-Seq_ESCs_Mouse1.37033880
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.37020699
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36502182
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.36251946
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.36088455
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.36021328
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34699224
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34422298
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.34368905
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.34174527
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33920008
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33690858
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.30405695
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29449580
88* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28870043
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28344455
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.25962631
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24505028
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.24292933
93* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.24071969
94KDM2B_26808549_Chip-Seq_REH_Human1.23679162
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.23333441
96FUS_26573619_Chip-Seq_HEK293_Human1.23323325
97SMAD4_21799915_ChIP-Seq_A2780_Human1.23025036
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20905218
99RNF2_27304074_Chip-Seq_NSC_Mouse1.18838355
100CJUN_26792858_Chip-Seq_BT549_Human1.17295849
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16497651
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.16101947
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.15333576
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14188116
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.13118898
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12328618
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12111353
108* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11814031
109ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11584923
110PU1_27457419_Chip-Seq_LIVER_Mouse1.10886887
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10773851
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10437388
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09749379
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09372954
115CTCF_18555785_Chip-Seq_ESCs_Mouse1.08899895
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08654927
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08331726
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08331726
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06973454
120CTCF_27219007_Chip-Seq_Bcells_Human1.06298818
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06148052
122ZNF263_19887448_ChIP-Seq_K562_Human1.06097055
123TP53_18474530_ChIP-ChIP_U2OS_Human1.04815459
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04379533
125AR_21572438_ChIP-Seq_LNCaP_Human1.04361305
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04310193
127DROSHA_22980978_ChIP-Seq_HELA_Human1.04015085
128TCF4_23295773_ChIP-Seq_U87_Human1.03754207
129STAT3_23295773_ChIP-Seq_U87_Human1.02238400
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02071651
131RUNX2_22187159_ChIP-Seq_PCA_Human0.99608360
132* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99453301
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99156565
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97454308
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96020359
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.95960660
137NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95741733
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94934310
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.94438160
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94079481
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93820416
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91452585
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90778961
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90067462
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89820191
146* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88717618
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87886786
148* LXR_22292898_ChIP-Seq_THP-1_Human0.87611624
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87538181
150CBP_21632823_ChIP-Seq_H3396_Human0.86821273
151BCAT_22108803_ChIP-Seq_LS180_Human0.83721677
152* SMC4_20622854_ChIP-Seq_HELA_Human0.81823515
153KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79247141
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79139240
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78450924
156* SA1_22415368_ChIP-Seq_MEFs_Mouse0.77250594
157LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77048396
158KLF4_19829295_ChIP-Seq_ESCs_Human0.75856950
159* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75056765
160WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73729745
161TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.73440835
162CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73022530
163SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72396863
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.70858543
165SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70628505
166HIF1A_21447827_ChIP-Seq_MCF-7_Human0.68982145
167AHR_22903824_ChIP-Seq_MCF-7_Human0.68549026
168SOX11_22085726_ChIP-Seq_ESNs_Mouse0.68429348
169NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67502574
170ELK3_25401928_ChIP-Seq_HUVEC_Human0.67462629
171TET1_21490601_ChIP-Seq_MESCs_Mouse0.67395613
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.66079890
173P68_20966046_ChIP-Seq_HELA_Human0.66009632
174RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64801334
175CTNNB1_20460455_ChIP-Seq_HCT116_Human0.64774018
176KDM2B_26808549_Chip-Seq_K562_Human0.64021030
177SA1_27219007_Chip-Seq_Bcells_Human0.63524902
178* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63298046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005670_abnormal_white_adipose4.99908037
2MP0005410_abnormal_fertilization3.68382713
3* MP0005666_abnormal_adipose_tissue3.32538642
4MP0003950_abnormal_plasma_membrane3.14286635
5MP0003136_yellow_coat_color2.97475387
6MP0002837_dystrophic_cardiac_calcinosis2.90135698
7MP0010329_abnormal_lipoprotein_level2.88923376
8MP0004185_abnormal_adipocyte_glucose2.76387128
9MP0004130_abnormal_muscle_cell2.73707847
10MP0002876_abnormal_thyroid_physiology2.60061789
11MP0004084_abnormal_cardiac_muscle2.57423479
12MP0005409_darkened_coat_color2.52064655
13MP0003724_increased_susceptibility_to2.44004690
14* MP0005375_adipose_tissue_phenotype2.34882353
15MP0005171_absent_coat_pigmentation2.33922477
16MP0001661_extended_life_span2.32973027
17MP0002971_abnormal_brown_adipose2.22144596
18MP0004742_abnormal_vestibular_system2.14732162
19MP0000566_synostosis2.12807835
20MP0000920_abnormal_myelination2.04439066
21MP0001188_hyperpigmentation1.97109890
22MP0003690_abnormal_glial_cell1.96565680
23MP0004381_abnormal_hair_follicle1.95030745
24MP0008438_abnormal_cutaneous_collagen1.93813053
25MP0003868_abnormal_feces_composition1.88757659
26MP0003011_delayed_dark_adaptation1.86257077
27MP0002638_abnormal_pupillary_reflex1.85756379
28MP0004087_abnormal_muscle_fiber1.77944464
29MP0002102_abnormal_ear_morphology1.77394609
30MP0005503_abnormal_tendon_morphology1.70873430
31MP0004215_abnormal_myocardial_fiber1.68965117
32MP0005379_endocrine/exocrine_gland_phen1.66499580
33MP0003880_abnormal_central_pattern1.65574647
34MP0003646_muscle_fatigue1.65257880
35MP0005645_abnormal_hypothalamus_physiol1.57386016
36MP0001486_abnormal_startle_reflex1.54321037
37MP0000003_abnormal_adipose_tissue1.53963061
38MP0005365_abnormal_bile_salt1.52506406
39MP0003186_abnormal_redox_activity1.51057370
40MP0005535_abnormal_body_temperature1.50843718
41MP0005167_abnormal_blood-brain_barrier1.44451501
42MP0000751_myopathy1.42877950
43MP0000759_abnormal_skeletal_muscle1.41925450
44MP0004147_increased_porphyrin_level1.40434528
45MP0003828_pulmonary_edema1.35705145
46MP0000013_abnormal_adipose_tissue1.35547733
47MP0002139_abnormal_hepatobiliary_system1.32617285
48MP0009780_abnormal_chondrocyte_physiolo1.31333817
49* MP0005334_abnormal_fat_pad1.29755042
50* MP0009115_abnormal_fat_cell1.26747835
51* MP0002078_abnormal_glucose_homeostasis1.24269096
52MP0010368_abnormal_lymphatic_system1.23646581
53MP0006138_congestive_heart_failure1.22413540
54MP0010630_abnormal_cardiac_muscle1.19483717
55MP0004272_abnormal_basement_membrane1.18756139
56MP0000749_muscle_degeneration1.15621775
57MP0003191_abnormal_cellular_cholesterol1.15417069
58MP0003959_abnormal_lean_body1.15331253
59MP0005620_abnormal_muscle_contractility1.15160438
60MP0008260_abnormal_autophagy1.13834448
61MP0003279_aneurysm1.11811328
62MP0005451_abnormal_body_composition1.10456161
63MP0002909_abnormal_adrenal_gland1.10394790
64MP0005330_cardiomyopathy1.09144067
65MP0005360_urolithiasis1.07767164
66MP0000026_abnormal_inner_ear1.07691164
67MP0005584_abnormal_enzyme/coenzyme_acti1.07544141
68MP0005369_muscle_phenotype1.07103822
69* MP0003698_abnormal_male_reproductive1.06899850
70MP0003705_abnormal_hypodermis_morpholog1.06881411
71MP0005423_abnormal_somatic_nervous1.04529105
72MP0000249_abnormal_blood_vessel1.01957144
73MP0001879_abnormal_lymphatic_vessel1.01535959
74MP0002106_abnormal_muscle_physiology1.01401222
75MP0009379_abnormal_foot_pigmentation1.01061790
76MP0006276_abnormal_autonomic_nervous1.00330826
77MP0001963_abnormal_hearing_physiology0.99906224
78MP0001501_abnormal_sleep_pattern0.99060263
79MP0004036_abnormal_muscle_relaxation0.98798696
80MP0002277_abnormal_respiratory_mucosa0.98200620
81MP0000747_muscle_weakness0.98133932
82MP0001727_abnormal_embryo_implantation0.97238933
83MP0002272_abnormal_nervous_system0.95495325
84MP0001905_abnormal_dopamine_level0.95200798
85MP0005452_abnormal_adipose_tissue0.95172738
86MP0006292_abnormal_olfactory_placode0.94474714
87MP0003137_abnormal_impulse_conducting0.94293056
88MP0001986_abnormal_taste_sensitivity0.93135517
89MP0002972_abnormal_cardiac_muscle0.92899096
90MP0000609_abnormal_liver_physiology0.92860442
91MP0005165_increased_susceptibility_to0.92084141
92MP0002269_muscular_atrophy0.91538641
93MP0005275_abnormal_skin_tensile0.90855895
94MP0004484_altered_response_of0.90636426
95MP0002933_joint_inflammation0.90492462
96* MP0002118_abnormal_lipid_homeostasis0.89902454
97MP0005647_abnormal_sex_gland0.87803945
98MP0008995_early_reproductive_senescence0.86985715
99MP0005551_abnormal_eye_electrophysiolog0.86725024
100MP0002970_abnormal_white_adipose0.86576124
101MP0002127_abnormal_cardiovascular_syste0.86569471
102MP0005266_abnormal_metabolism0.86371634
103MP0000230_abnormal_systemic_arterial0.84552502
104MP0002295_abnormal_pulmonary_circulatio0.83255697
105MP0008775_abnormal_heart_ventricle0.82949390
106MP0005332_abnormal_amino_acid0.82467463
107MP0004142_abnormal_muscle_tone0.82428595
108MP0005595_abnormal_vascular_smooth0.79932300
109MP0003948_abnormal_gas_homeostasis0.79772266
110MP0005385_cardiovascular_system_phenoty0.79757015
111MP0001544_abnormal_cardiovascular_syste0.79757015
112MP0004145_abnormal_muscle_electrophysio0.78178914
113MP0001177_atelectasis0.76609216
114MP0005388_respiratory_system_phenotype0.76577623
115MP0002133_abnormal_respiratory_system0.76577623
116MP0004510_myositis0.76542900
117MP0004043_abnormal_pH_regulation0.76466859
118MP0001529_abnormal_vocalization0.76375472
119MP0005164_abnormal_response_to0.75912812
120MP0000778_abnormal_nervous_system0.75360672
121MP0002108_abnormal_muscle_morphology0.74889910
122MP0000343_altered_response_to0.74864562
123MP0005448_abnormal_energy_balance0.74835770
124MP0001764_abnormal_homeostasis0.74278354
125MP0000767_abnormal_smooth_muscle0.73527532
126MP0003878_abnormal_ear_physiology0.73214512
127MP0005377_hearing/vestibular/ear_phenot0.73214512
128MP0002332_abnormal_exercise_endurance0.73040704
129MP0003938_abnormal_ear_development0.72758318
130MP0004085_abnormal_heartbeat0.72288376
131MP0000383_abnormal_hair_follicle0.70988669
132MP0006036_abnormal_mitochondrial_physio0.70513886
133MP0001485_abnormal_pinna_reflex0.70483270
134* MP0003953_abnormal_hormone_level0.69333171
135MP0004134_abnormal_chest_morphology0.68914395
136MP0003045_fibrosis0.68533024
137MP0000750_abnormal_muscle_regeneration0.67316202
138MP0001958_emphysema0.66274433
139MP0001929_abnormal_gametogenesis0.66247285
140MP0003879_abnormal_hair_cell0.64999451
141* MP0009643_abnormal_urine_homeostasis0.61541268
142MP0009840_abnormal_foam_cell0.57663688
143MP0001881_abnormal_mammary_gland0.55884109

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.41395290
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.41395290
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.11400230
4Increased variability in muscle fiber diameter (HP:0003557)4.79800751
5Asymmetric septal hypertrophy (HP:0001670)4.40763268
6Abnormality of skeletal muscle fiber size (HP:0012084)4.22237746
7Sudden death (HP:0001699)4.20928256
8Hyperlipoproteinemia (HP:0010980)4.01784346
9Bundle branch block (HP:0011710)3.76180420
10Complement deficiency (HP:0004431)3.72476987
11Abnormal respiratory motile cilium physiology (HP:0012261)3.70536175
12Insulin resistance (HP:0000855)3.66560629
13Duplicated collecting system (HP:0000081)3.65348054
14Abnormal respiratory epithelium morphology (HP:0012253)3.63957011
15Abnormal respiratory motile cilium morphology (HP:0005938)3.63957011
16Abnormal ciliary motility (HP:0012262)3.60703115
17Skin nodule (HP:0200036)3.55301262
18Neck muscle weakness (HP:0000467)3.45873749
19Increased connective tissue (HP:0009025)3.41040979
20Type 1 muscle fiber predominance (HP:0003803)3.30182165
21Epidermoid cyst (HP:0200040)3.29275628
22Protrusio acetabuli (HP:0003179)3.24134754
23Abnormality of the renal collecting system (HP:0004742)3.21305039
24Oligomenorrhea (HP:0000876)3.20813115
25Muscle fiber splitting (HP:0003555)3.20440827
26Myocardial infarction (HP:0001658)3.16964977
27Xanthomatosis (HP:0000991)3.10642108
28Atrioventricular block (HP:0001678)3.10448231
29Hemorrhage of the eye (HP:0011885)3.09657229
30Acanthosis nigricans (HP:0000956)3.08868581
31Abnormality of complement system (HP:0005339)3.07182034
32Heart block (HP:0012722)3.03748004
33Dilated cardiomyopathy (HP:0001644)3.02486733
34Abnormal atrioventricular conduction (HP:0005150)2.99890214
35Nausea (HP:0002018)2.98731471
36Hyperglycinuria (HP:0003108)2.98487884
37Pigmentary retinal degeneration (HP:0001146)2.88553961
38Tubulointerstitial nephritis (HP:0001970)2.87570860
39Septo-optic dysplasia (HP:0100842)2.84735080
40Sensory axonal neuropathy (HP:0003390)2.84657630
41Acute necrotizing encephalopathy (HP:0006965)2.83686260
42Hypercholesterolemia (HP:0003124)2.83130492
43Parakeratosis (HP:0001036)2.82008197
44Renal cortical cysts (HP:0000803)2.81549993
45Frequent falls (HP:0002359)2.77118860
46EMG: myopathic abnormalities (HP:0003458)2.73672090
47Spinal rigidity (HP:0003306)2.72722476
48Abnormality of the calf musculature (HP:0001430)2.70579164
49Supraventricular tachycardia (HP:0004755)2.69993656
50Supraventricular arrhythmia (HP:0005115)2.69639198
51Insulin-resistant diabetes mellitus (HP:0000831)2.67238383
52Increased serum pyruvate (HP:0003542)2.65572659
53Hypertriglyceridemia (HP:0002155)2.61690338
54Distal lower limb muscle weakness (HP:0009053)2.58817673
55Polycythemia (HP:0001901)2.57904779
56Growth hormone excess (HP:0000845)2.57256799
57Axonal loss (HP:0003447)2.56883723
58Bone cyst (HP:0012062)2.56358319
59Back pain (HP:0003418)2.54889171
60Acute encephalopathy (HP:0006846)2.54315441
61Syncope (HP:0001279)2.50621539
62Right ventricular cardiomyopathy (HP:0011663)2.47753750
63Progressive macrocephaly (HP:0004481)2.44793301
64Systemic lupus erythematosus (HP:0002725)2.42390104
65Methylmalonic acidemia (HP:0002912)2.42119225
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.41457221
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41457221
68Hypercortisolism (HP:0001578)2.41288182
69Hypoplasia of the iris (HP:0007676)2.41282943
70Rimmed vacuoles (HP:0003805)2.40646184
71Abnormal mitochondria in muscle tissue (HP:0008316)2.38459661
72White forelock (HP:0002211)2.38217361
73Abnormality of glycine metabolism (HP:0010895)2.36859726
74Abnormality of serine family amino acid metabolism (HP:0010894)2.36859726
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36254604
76Increased muscle lipid content (HP:0009058)2.35428989
77Abnormality of glycolysis (HP:0004366)2.34872040
78Gowers sign (HP:0003391)2.34613370
79Ileus (HP:0002595)2.32575165
80Patchy hypopigmentation of hair (HP:0011365)2.32195105
81Optic disc pallor (HP:0000543)2.31555190
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31038895
83Dicarboxylic aciduria (HP:0003215)2.31038895
84Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30076061
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28997497
86Bradycardia (HP:0001662)2.28743450
87Difficulty running (HP:0009046)2.28392988
88Absent septum pellucidum (HP:0001331)2.28101538
89Abnormal eating behavior (HP:0100738)2.27910997
90Abnormality of the foot musculature (HP:0001436)2.24848851
91Aortic aneurysm (HP:0004942)2.24376407
92Hepatic necrosis (HP:0002605)2.23933236
93Aplasia cutis congenita (HP:0001057)2.21051141
943-Methylglutaconic aciduria (HP:0003535)2.20849258
95Muscle hypertrophy of the lower extremities (HP:0008968)2.20212966
96Prominent supraorbital ridges (HP:0000336)2.20061421
97Exercise-induced myalgia (HP:0003738)2.19209925
98Mitochondrial inheritance (HP:0001427)2.19030318
99Ventricular arrhythmia (HP:0004308)2.18349955
100Foot dorsiflexor weakness (HP:0009027)2.18215968
101Congenital sensorineural hearing impairment (HP:0008527)2.17616230
102Mildly elevated creatine phosphokinase (HP:0008180)2.17051986
103Subcapsular cataract (HP:0000523)2.15786391
104Myoglobinuria (HP:0002913)2.15604974
105Myotonia (HP:0002486)2.15032522
106Polar cataract (HP:0010696)2.12912263
107Hyporeflexia of lower limbs (HP:0002600)2.12738648
108Pulmonary artery stenosis (HP:0004415)2.12609962
109Hypoalphalipoproteinemia (HP:0003233)2.12473652
110Nasolacrimal duct obstruction (HP:0000579)2.12433198
111Lymphangioma (HP:0100764)2.12098004
112Thyroid-stimulating hormone excess (HP:0002925)2.11970562
113Optic nerve hypoplasia (HP:0000609)2.10696698
114Joint hemorrhage (HP:0005261)2.10695447
115Scapular winging (HP:0003691)2.10672770
116EMG: neuropathic changes (HP:0003445)2.08012804
117Metabolic alkalosis (HP:0200114)2.07873108
118Muscle stiffness (HP:0003552)2.07627514
119Ectopia lentis (HP:0001083)2.05906507
120Fibular hypoplasia (HP:0003038)2.05875462
121Rhabdomyolysis (HP:0003201)2.05083051
122Reduced subcutaneous adipose tissue (HP:0003758)2.04659278
123Prolonged QT interval (HP:0001657)2.02484106
124Lipid accumulation in hepatocytes (HP:0006561)2.01283305
125Atrial fibrillation (HP:0005110)2.01281386
126Abnormality of the septum pellucidum (HP:0007375)2.00874185
127Amyloidosis (HP:0011034)2.00191992
128Abnormality of the left ventricular outflow tract (HP:0011103)2.00055629
129Subaortic stenosis (HP:0001682)2.00055629
130Abnormality of the axillary hair (HP:0100134)1.99120583
131Abnormality of secondary sexual hair (HP:0009888)1.99120583
132Calf muscle hypertrophy (HP:0008981)1.98516660
133Lipoatrophy (HP:0100578)1.98346167
134Muscle fiber inclusion bodies (HP:0100299)1.98112224
135Conical tooth (HP:0000698)1.97518262
136Hyperkalemia (HP:0002153)1.96136131
137Retinal dysplasia (HP:0007973)1.96125333
138Potter facies (HP:0002009)1.96105339
139Facial shape deformation (HP:0011334)1.96105339
140Infantile muscular hypotonia (HP:0008947)1.95937584
141Rhinitis (HP:0012384)1.95766743
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.95200356
143Bulbar palsy (HP:0001283)1.95193472
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95101906
145Long foot (HP:0001833)1.94900255
146Nephronophthisis (HP:0000090)1.93822943
147Synostosis involving the elbow (HP:0003938)1.92685898
148Humeroradial synostosis (HP:0003041)1.92685898
149Striae distensae (HP:0001065)1.92534336
150Neurofibrillary tangles (HP:0002185)1.92049716
151Short tibia (HP:0005736)1.91763264
152Vertebral compression fractures (HP:0002953)1.91655230
153Abnormality of fatty-acid metabolism (HP:0004359)1.91425927
154Tubulointerstitial abnormality (HP:0001969)1.91376812
155Hepatocellular necrosis (HP:0001404)1.91238815
156Abnormality of proline metabolism (HP:0010907)1.89678055
157Hydroxyprolinuria (HP:0003080)1.89678055
158Accelerated skeletal maturation (HP:0005616)1.88878066
159Abnormality of the renal cortex (HP:0011035)1.88085719
160Increased CSF lactate (HP:0002490)1.87108285
161Abnormality of the renal medulla (HP:0100957)1.85932317
162Renal Fanconi syndrome (HP:0001994)1.84808451
163Abnormality of renal resorption (HP:0011038)1.82998047
164Decreased central vision (HP:0007663)1.82164138
165Methylmalonic aciduria (HP:0012120)1.77931663
166Duplication of thumb phalanx (HP:0009942)1.77720977
167Exercise intolerance (HP:0003546)1.77449352
168Upper limb muscle weakness (HP:0003484)1.77239158
169Hypomagnesemia (HP:0002917)1.76273396
170Stage 5 chronic kidney disease (HP:0003774)1.74582665
171Cerebral edema (HP:0002181)1.73829378
172Increased hepatocellular lipid droplets (HP:0006565)1.72973503
173Ventricular tachycardia (HP:0004756)1.72904537
174Abnormality of molar morphology (HP:0011070)1.72867041
175Abnormality of molar (HP:0011077)1.72867041
176Alacrima (HP:0000522)1.71941293
177Hepatosplenomegaly (HP:0001433)1.71935928
178Abnormality of the lacrimal duct (HP:0011481)1.71591229
179Primary atrial arrhythmia (HP:0001692)1.71298699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.70588342
2CASK3.26355867
3TRIB33.07607497
4TTN2.96134724
5RIPK12.80115084
6TGFBR22.71789267
7TIE12.70879233
8DDR22.63115904
9CAMK1D2.52034883
10PDK42.51807740
11PDK32.51807740
12INSRR2.50614561
13CAMK1G2.42017285
14PDK22.39582816
15ERN12.37328790
16PKN12.31223400
17TESK12.31167628
18OXSR12.29924146
19WNK42.03844530
20BCR1.98713718
21IRAK31.89167271
22TNIK1.87258201
23MAP3K61.84703633
24ICK1.77580843
25ZAK1.62403129
26MAPK41.61828161
27IRAK21.60438106
28MAPKAPK31.56402352
29EPHB11.55315871
30LATS21.52484502
31BCKDK1.49940347
32OBSCN1.45960184
33STK161.43831819
34IRAK11.42421991
35NEK91.41205580
36DMPK1.39860589
37NEK61.36619949
38EIF2AK21.35609719
39MUSK1.34135963
40PHKG21.33290937
41PHKG11.33290937
42ABL21.31068351
43PDGFRA1.29955512
44GRK11.27723558
45CAMKK21.26736623
46EPHA31.26694544
47GRK51.26145394
48GRK71.24273684
49WNK11.22062820
50EEF2K1.21967315
51PRKAA21.20870065
52MAP3K71.17252555
53PINK11.17029277
54MKNK21.15047482
55PBK1.14850337
56IRAK41.13802718
57PIK3CA1.09021747
58ADRBK21.08438435
59LATS11.04706102
60BMPR1B1.03914251
61PRKACG1.03609700
62PNCK1.01013940
63MYLK1.00397409
64CDC42BPA1.00151497
65MAP2K10.99115747
66MAPKAPK50.97139993
67NLK0.97032794
68PRPF4B0.92013089
69LMTK20.90456098
70BLK0.89192332
71BMPR20.87349308
72MAPK150.87311342
73MAP3K140.87187388
74CLK10.87001981
75CAMK2D0.86740369
76PRKCE0.86578025
77MST40.84883030
78YES10.83945386
79CDK60.83175128
80PRKD30.81603352
81FGR0.80228437
82PTK2B0.79447796
83FGFR20.78318522
84TXK0.77528722
85DYRK20.77210640
86EPHB20.75966895
87SGK2230.75718988
88SGK4940.75718988
89MET0.73638792
90MOS0.72882767
91CDK30.72862682
92CDK90.72234239
93FER0.70898246
94MAPK130.70760587
95PKN20.69086013
96ADRBK10.67253888
97PDPK10.66416157
98PDGFRB0.66078183
99FGFR40.65165671
100MAP3K130.65018484
101PAK30.64473776
102AKT30.64243268
103STK380.64220581
104PRKD20.64022508
105MARK20.63951910
106CAMK2B0.63600605
107PRKCQ0.62840439
108NUAK10.62301904
109CAMK2A0.61704206
110DAPK30.61188082
111ARAF0.61110672
112SIK10.60856483
113JAK20.56994564
114CAMK40.56977986
115PRKD10.56069879
116ROCK10.55991357
117KIT0.55601492
118PRKACB0.55417770
119PRKG10.54069159
120CSNK1G10.53086090
121PRKACA0.52226492
122TYK20.51736403
123CAMK10.50875803
124ROCK20.50399348
125KSR20.49306884
126MAP2K70.49287523
127AKT20.48881102
128MST1R0.48664515
129MTOR0.48239729
130PIK3CG0.47941816
131RPS6KA30.47591873
132MARK10.47556081
133MAPK30.46589757
134PAK20.46388521
135GSK3A0.46371268
136TRPM70.45404195
137RET0.42501100
138PRKAA10.42368179
139CSNK1A1L0.42106647
140MAPK120.41551912
141ILK0.40997969
142STK38L0.40512933
143PDK10.40079040
144JAK10.40023502
145MKNK10.39688731
146CAMK2G0.38573304
147PTK20.38404641
148MAP2K40.37635697
149MAPK70.36614956
150KDR0.35722512
151TBK10.35083188
152CCNB10.34698802
153RIPK40.34481780
154IGF1R0.33619126
155SGK20.33465449
156MAP3K30.32595429
157TNK20.32501068
158CSK0.31934370
159SGK10.31500463
160INSR0.31307529
161NTRK20.31281737

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.96446330
2Propanoate metabolism_Homo sapiens_hsa006403.94231838
3Fatty acid elongation_Homo sapiens_hsa000623.35502306
4Fatty acid metabolism_Homo sapiens_hsa012122.84249181
5* PPAR signaling pathway_Homo sapiens_hsa033202.70851671
6* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.60109815
7Oxidative phosphorylation_Homo sapiens_hsa001902.50973541
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48644105
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37403940
10Fatty acid degradation_Homo sapiens_hsa000712.13607216
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08201505
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03411621
13Glycerolipid metabolism_Homo sapiens_hsa005611.90568864
14Parkinsons disease_Homo sapiens_hsa050121.89023249
15Ether lipid metabolism_Homo sapiens_hsa005651.85580753
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83002162
17Tryptophan metabolism_Homo sapiens_hsa003801.81105079
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77882408
19Linoleic acid metabolism_Homo sapiens_hsa005911.73480433
20Alzheimers disease_Homo sapiens_hsa050101.73313681
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72380222
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70260314
23Arachidonic acid metabolism_Homo sapiens_hsa005901.60182832
24Vitamin B6 metabolism_Homo sapiens_hsa007501.59342637
25Sphingolipid metabolism_Homo sapiens_hsa006001.51066134
26beta-Alanine metabolism_Homo sapiens_hsa004101.50875566
27Cardiac muscle contraction_Homo sapiens_hsa042601.50674800
28Huntingtons disease_Homo sapiens_hsa050161.49482487
29Autoimmune thyroid disease_Homo sapiens_hsa053201.47808765
30Pyruvate metabolism_Homo sapiens_hsa006201.47330481
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41732565
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34454712
33Arginine biosynthesis_Homo sapiens_hsa002201.25325942
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22951918
35Fat digestion and absorption_Homo sapiens_hsa049751.20610906
36Butanoate metabolism_Homo sapiens_hsa006501.19748776
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.10960486
38Peroxisome_Homo sapiens_hsa041461.10303465
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09648133
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.08248730
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06124979
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04870882
43Steroid biosynthesis_Homo sapiens_hsa001001.03104384
44Renin secretion_Homo sapiens_hsa049240.99088549
45Insulin signaling pathway_Homo sapiens_hsa049100.98414336
46Taste transduction_Homo sapiens_hsa047420.98206228
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96275372
48Sulfur relay system_Homo sapiens_hsa041220.95757945
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95314969
50Complement and coagulation cascades_Homo sapiens_hsa046100.93931784
51Insulin resistance_Homo sapiens_hsa049310.92675521
52Sulfur metabolism_Homo sapiens_hsa009200.89361174
53Morphine addiction_Homo sapiens_hsa050320.88243871
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86389133
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84962023
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84814558
57Chemical carcinogenesis_Homo sapiens_hsa052040.84081580
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83859999
59Vitamin digestion and absorption_Homo sapiens_hsa049770.83232570
60Mineral absorption_Homo sapiens_hsa049780.81696198
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81643395
62Axon guidance_Homo sapiens_hsa043600.81081002
63AMPK signaling pathway_Homo sapiens_hsa041520.79495679
64Ovarian steroidogenesis_Homo sapiens_hsa049130.78864150
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78286127
66ECM-receptor interaction_Homo sapiens_hsa045120.76503668
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74423720
68Phototransduction_Homo sapiens_hsa047440.74211749
69Dilated cardiomyopathy_Homo sapiens_hsa054140.73261470
70Serotonergic synapse_Homo sapiens_hsa047260.72333044
71Bile secretion_Homo sapiens_hsa049760.72160136
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71778962
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70552126
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69389448
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69202181
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67802855
77Protein digestion and absorption_Homo sapiens_hsa049740.66683567
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66555011
79Malaria_Homo sapiens_hsa051440.66539738
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66264071
81Nicotine addiction_Homo sapiens_hsa050330.65407642
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65361894
83Calcium signaling pathway_Homo sapiens_hsa040200.64886236
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.64526603
85Tyrosine metabolism_Homo sapiens_hsa003500.63813237
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63769931
87Metabolic pathways_Homo sapiens_hsa011000.62156714
88Starch and sucrose metabolism_Homo sapiens_hsa005000.61841499
89Protein export_Homo sapiens_hsa030600.61590720
90Focal adhesion_Homo sapiens_hsa045100.58902288
91Fanconi anemia pathway_Homo sapiens_hsa034600.57105416
92cAMP signaling pathway_Homo sapiens_hsa040240.56930117
93ABC transporters_Homo sapiens_hsa020100.56796372
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54862159
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54299021
96Salivary secretion_Homo sapiens_hsa049700.54026620
97Lysine degradation_Homo sapiens_hsa003100.52684691
98Histidine metabolism_Homo sapiens_hsa003400.52663585
99Graft-versus-host disease_Homo sapiens_hsa053320.51200054
100Circadian rhythm_Homo sapiens_hsa047100.50443603
101Retinol metabolism_Homo sapiens_hsa008300.48717421
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48274573
103Rheumatoid arthritis_Homo sapiens_hsa053230.47900250
104Glutamatergic synapse_Homo sapiens_hsa047240.47422768
105Arginine and proline metabolism_Homo sapiens_hsa003300.44610621
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44107186
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43608088
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.39816056
109Carbon metabolism_Homo sapiens_hsa012000.39403969
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.39172049
111Ras signaling pathway_Homo sapiens_hsa040140.37920099
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.37856573
113Other glycan degradation_Homo sapiens_hsa005110.35447392
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.34755564
115Glucagon signaling pathway_Homo sapiens_hsa049220.34512440
116Hematopoietic cell lineage_Homo sapiens_hsa046400.33929077
117Glutathione metabolism_Homo sapiens_hsa004800.33743838
118Folate biosynthesis_Homo sapiens_hsa007900.33371065
119Allograft rejection_Homo sapiens_hsa053300.32651756
120Staphylococcus aureus infection_Homo sapiens_hsa051500.30596345
121Phenylalanine metabolism_Homo sapiens_hsa003600.30351615
122Collecting duct acid secretion_Homo sapiens_hsa049660.29941648
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29340595
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28936282
125Dorso-ventral axis formation_Homo sapiens_hsa043200.28840983
126Purine metabolism_Homo sapiens_hsa002300.27133990
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26796299
128Renin-angiotensin system_Homo sapiens_hsa046140.26687401
129Type II diabetes mellitus_Homo sapiens_hsa049300.26226319
130Fructose and mannose metabolism_Homo sapiens_hsa000510.25858064
131Basal cell carcinoma_Homo sapiens_hsa052170.25732006
132Asthma_Homo sapiens_hsa053100.24929440
133Hedgehog signaling pathway_Homo sapiens_hsa043400.24096797
134Tight junction_Homo sapiens_hsa045300.23805611
135Biosynthesis of amino acids_Homo sapiens_hsa012300.23474425
136Oxytocin signaling pathway_Homo sapiens_hsa049210.19588503
137Pancreatic secretion_Homo sapiens_hsa049720.12788320
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12049638
139Cocaine addiction_Homo sapiens_hsa050300.10938364
140Pentose phosphate pathway_Homo sapiens_hsa000300.09538546
141GnRH signaling pathway_Homo sapiens_hsa049120.06307544

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