ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protoporphyrinogen IX biosynthetic process (GO:0006782)	7.97070586
2	low-density lipoprotein particle clearance (GO:0034383)	7.31172119
3	N-acetylneuraminate metabolic process (GO:0006054)	6.88561828
4	insulin-like growth factor receptor signaling pathway (GO:0048009)	6.61412255
5	protoporphyrinogen IX metabolic process (GO:0046501)	6.36543639
6	positive regulation of histone deacetylation (GO:0031065)	6.32321379
7	triglyceride catabolic process (GO:0019433)	6.06366418
8	regulation of sequestering of triglyceride (GO:0010889)	5.97802700
9	acylglycerol catabolic process (GO:0046464)	5.54716838
10	neutral lipid catabolic process (GO:0046461)	5.54716838
11	cellular extravasation (GO:0045123)	5.30884394
12	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	5.25500090
13	fatty acid homeostasis (GO:0055089)	4.81392729
14	centriole replication (GO:0007099)	4.80451854
15	negative regulation of phagocytosis (GO:0050765)	4.62175770
16	cellular response to cadmium ion (GO:0071276)	4.59513450
17	plasma lipoprotein particle clearance (GO:0034381)	4.49418434
18	positive regulation of protein deacetylation (GO:0090312)	4.46704667
19	amino sugar catabolic process (GO:0046348)	4.42900472
20	regulation of MHC class II biosynthetic process (GO:0045346)	4.39700892
21	polyol transport (GO:0015791)	4.37428421
22	diacylglycerol metabolic process (GO:0046339)	4.33839920
23	purine deoxyribonucleotide catabolic process (GO:0009155)	4.22913308
24	low-density lipoprotein particle remodeling (GO:0034374)	4.22798660
25	response to folic acid (GO:0051593)	4.12950894
26	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.08478072
27	L-phenylalanine catabolic process (GO:0006559)	4.08478072
28	positive regulation of lipid storage (GO:0010884)	4.08004013
29	glycerolipid catabolic process (GO:0046503)	3.97536179
30	reactive oxygen species biosynthetic process (GO:1903409)	3.92070992
31	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.88455191
32	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.88455191
33	L-phenylalanine metabolic process (GO:0006558)	3.85955804
34	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.85955804
35	positive regulation of chemokine biosynthetic process (GO:0045080)	3.85599903
36	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.85051096
37	base-excision repair, AP site formation (GO:0006285)	3.84884117
38	thalamus development (GO:0021794)	3.83620706
39	angiotensin maturation (GO:0002003)	3.77147550
40	plasma lipoprotein particle remodeling (GO:0034369)	3.74176233
41	protein-lipid complex remodeling (GO:0034368)	3.74176233
42	macromolecular complex remodeling (GO:0034367)	3.74176233
43	alpha-linolenic acid metabolic process (GO:0036109)	3.70831452
44	acylglycerol homeostasis (GO:0055090)	3.70818492
45	triglyceride homeostasis (GO:0070328)	3.70818492
46	NADH metabolic process (GO:0006734)	3.69442697
47	macrophage chemotaxis (GO:0048246)	3.68860239
48	ethanol oxidation (GO:0006069)	3.68563092
49	N-acetylglucosamine metabolic process (GO:0006044)	3.64901558
50	regulation of glycolytic process (GO:0006110)	3.63836001
51	transcytosis (GO:0045056)	3.62580893
52	heme biosynthetic process (GO:0006783)	3.59020056
53	cytokinetic process (GO:0032506)	3.55517061
54	negative regulation of growth of symbiont in host (GO:0044130)	3.55307929
55	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.55307929
56	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.55307929
57	regulation of growth of symbiont in host (GO:0044126)	3.55307929
58	triglyceride biosynthetic process (GO:0019432)	3.53444671
59	regulation of chemokine biosynthetic process (GO:0045073)	3.47816212
60	ethanol metabolic process (GO:0006067)	3.43974666
61	regulation of cholesterol storage (GO:0010885)	3.43823925
62	positive regulation of glycolytic process (GO:0045821)	3.43362656
63	acylglycerol biosynthetic process (GO:0046463)	3.43072003
64	neutral lipid biosynthetic process (GO:0046460)	3.43072003
65	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.38775421
66	phospholipid homeostasis (GO:0055091)	3.38080620
67	negative regulation of fibrinolysis (GO:0051918)	3.37079970
68	fatty acid transmembrane transport (GO:1902001)	3.33153206
69	lipid storage (GO:0019915)	3.30604115
70	triglyceride metabolic process (GO:0006641)	3.30249842
71	primary alcohol metabolic process (GO:0034308)	3.24148474
72	centriole assembly (GO:0098534)	3.14892889
73	regulation of triglyceride catabolic process (GO:0010896)	3.14686510
74	negative regulation of interleukin-2 production (GO:0032703)	3.14620464
75	lipid particle organization (GO:0034389)	3.11502122
76	acylglycerol metabolic process (GO:0006639)	3.10290920
77	positive regulation of lipoprotein lipase activity (GO:0051006)	3.08122201
78	positive regulation of triglyceride lipase activity (GO:0061365)	3.08122201
79	microglial cell activation (GO:0001774)	3.07087748
80	amino-acid betaine metabolic process (GO:0006577)	3.06883392
81	neutral lipid metabolic process (GO:0006638)	3.05417208
82	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	3.03880060
83	primary alcohol catabolic process (GO:0034310)	3.03016250
84	carnitine shuttle (GO:0006853)	3.01669700
85	brown fat cell differentiation (GO:0050873)	3.00782972
86	regulation of histone deacetylation (GO:0031063)	3.00080432
87	cholesterol homeostasis (GO:0042632)	2.99893892
88	acetyl-CoA metabolic process (GO:0006084)	2.99891461
89	regulation of fatty acid transport (GO:2000191)	2.99384912
90	glial cell migration (GO:0008347)	2.99258500
91	biotin metabolic process (GO:0006768)	2.96999615
92	response to phenylpropanoid (GO:0080184)	2.96994352
93	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.94528823
94	oxaloacetate metabolic process (GO:0006107)	2.92999673
95	sterol homeostasis (GO:0055092)	2.92588020
96	glycerol metabolic process (GO:0006071)	2.90831421
97	thioester metabolic process (GO:0035383)	2.90811376
98	acyl-CoA metabolic process (GO:0006637)	2.90811376
99	regulation of protein import into nucleus, translocation (GO:0033158)	2.90151869
100	heme metabolic process (GO:0042168)	2.89355536

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	9.45999559
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.49153720
3	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	4.03683567
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.60092000
5	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.39090363
6	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.35023597
7	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.20505101
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.07299753
9	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.03198701
10	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.60843302
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.39713809
12	CLOCK_20551151_ChIP-Seq_293T_Human	2.18285117
13	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.17151333
14	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.16529607
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.99884690
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.72601199
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.65844716
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58217522
19	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.55603011
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54999126
21	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.50769826
22	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48545739
23	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.42684399
24	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40081033
25	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.39036868
26	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38123550
27	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.31997650
28	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.26110346
29	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.25586899
30	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.23649307
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.22435955
32	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.22406539
33	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.18348989
34	RXR_22108803_ChIP-Seq_LS180_Human	1.17230624
35	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16619277
36	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.14221025
37	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.11628886
38	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.11628886
39	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.10723883
40	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.10396303
41	LXR_22292898_ChIP-Seq_THP-1_Human	1.09974874
42	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.08299831
43	* CJUN_26792858_Chip-Seq_BT549_Human	1.06117117
44	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05576725
45	EOMES_21245162_ChIP-Seq_HESCs_Human	1.02964415
46	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.01256939
47	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00349410
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99719725
49	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.99463458
50	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.97471537
51	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96984364
52	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.96242240
53	SCL_19346495_ChIP-Seq_HPC-7_Human	0.95483074
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94577356
55	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.94329360
56	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.93677283
57	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93619451
58	SMC4_20622854_ChIP-Seq_HELA_Human	0.93051090
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92999472
60	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.92660823
61	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92520599
62	BCAT_22108803_ChIP-Seq_LS180_Human	0.88927586
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.88326257
64	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.88041983
65	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.86906911
66	GATA4_25053715_ChIP-Seq_YYC3_Human	0.83692007
67	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.82993591
68	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.81204981
69	CTCF_27219007_Chip-Seq_Bcells_Human	0.81008540
70	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.79973743
71	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.79435849
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.79210889
73	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.77716942
74	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.77716942
75	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.77514085
76	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.77248413
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.76087723
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.74566726
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.73213223
80	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.73151710
81	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.73107025
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.72783131
83	SA1_27219007_Chip-Seq_Bcells_Human	0.72541676
84	RAC3_21632823_ChIP-Seq_H3396_Human	0.72375995
85	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.72312940
86	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.72050449
87	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.71610073
88	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.71092756
89	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.70674910
90	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.70574141
91	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.70050517
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.68301733
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.67712009
94	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.67441315
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.66298286
96	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.65963130
97	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.65889100
98	BCL6_27268052_Chip-Seq_Bcells_Human	0.65553145
99	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.64745756
100	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.64654510

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	8.33348429
2	MP0005083_abnormal_biliary_tract	6.07132211
3	MP0005365_abnormal_bile_salt	4.44652392
4	MP0005666_abnormal_adipose_tissue	4.02467198
5	MP0005375_adipose_tissue_phenotype	3.62319103
6	MP0004130_abnormal_muscle_cell	3.40628938
7	MP0010329_abnormal_lipoprotein_level	3.37542315
8	MP0002971_abnormal_brown_adipose	3.23421851
9	MP0000003_abnormal_adipose_tissue	3.16312388
10	MP0008961_abnormal_basal_metabolism	3.04754897
11	MP0005085_abnormal_gallbladder_physiolo	3.03079094
12	MP0003252_abnormal_bile_duct	2.85463749
13	MP0002139_abnormal_hepatobiliary_system	2.76855961
14	MP0009115_abnormal_fat_cell	2.65565483
15	MP0002970_abnormal_white_adipose	2.13979612
16	MP0005334_abnormal_fat_pad	2.13180298
17	MP0003959_abnormal_lean_body	2.01602271
18	MP0002118_abnormal_lipid_homeostasis	1.99144076
19	MP0004185_abnormal_adipocyte_glucose	1.91867843
20	MP0005167_abnormal_blood-brain_barrier	1.91634441
21	MP0003868_abnormal_feces_composition	1.89483696
22	MP0000751_myopathy	1.88546383
23	MP0005448_abnormal_energy_balance	1.70761345
24	MP0006138_congestive_heart_failure	1.68431533
25	MP0008875_abnormal_xenobiotic_pharmacok	1.65268086
26	MP0003195_calcinosis	1.57886567
27	MP0005360_urolithiasis	1.55591902
28	MP0004043_abnormal_pH_regulation	1.54956392
29	MP0003828_pulmonary_edema	1.51301532
30	MP0010368_abnormal_lymphatic_system	1.50908213
31	MP0003011_delayed_dark_adaptation	1.45872156
32	MP0005535_abnormal_body_temperature	1.41408424
33	MP0002876_abnormal_thyroid_physiology	1.37041235
34	MP0004084_abnormal_cardiac_muscle	1.30837977
35	MP0002837_dystrophic_cardiac_calcinosis	1.27863263
36	MP0000343_altered_response_to	1.26785010
37	MP0004036_abnormal_muscle_relaxation	1.22975443
38	MP0005451_abnormal_body_composition	1.22106488
39	MP0004272_abnormal_basement_membrane	1.20361733
40	MP0000013_abnormal_adipose_tissue	1.15440327
41	MP0004087_abnormal_muscle_fiber	1.14782793
42	MP0001661_extended_life_span	1.13846721
43	MP0002078_abnormal_glucose_homeostasis	1.13443186
44	MP0001544_abnormal_cardiovascular_syste	1.11908502
45	MP0005385_cardiovascular_system_phenoty	1.11908502
46	MP0005452_abnormal_adipose_tissue	1.11016122
47	MP0004215_abnormal_myocardial_fiber	1.07004187
48	MP0009643_abnormal_urine_homeostasis	1.04912916
49	MP0003186_abnormal_redox_activity	1.04579818
50	MP0005330_cardiomyopathy	1.04457342
51	MP0003690_abnormal_glial_cell	1.04065405
52	MP0005266_abnormal_metabolism	1.03393482
53	MP0000609_abnormal_liver_physiology	1.01083659
54	MP0002909_abnormal_adrenal_gland	0.99053591
55	MP0006036_abnormal_mitochondrial_physio	0.98756676
56	MP0000749_muscle_degeneration	0.97084678
57	MP0002972_abnormal_cardiac_muscle	0.95240853
58	MP0001502_abnormal_circadian_rhythm	0.94190481
59	MP0003191_abnormal_cellular_cholesterol	0.93703144
60	MP0008775_abnormal_heart_ventricle	0.93309372
61	MP0000249_abnormal_blood_vessel	0.90555885
62	MP0008058_abnormal_DNA_repair	0.89485607
63	MP0002127_abnormal_cardiovascular_syste	0.88703697
64	MP0005164_abnormal_response_to	0.87940083
65	MP0005332_abnormal_amino_acid	0.87458090
66	MP0002295_abnormal_pulmonary_circulatio	0.87286086
67	MP0003566_abnormal_cell_adhesion	0.86428855
68	MP0000759_abnormal_skeletal_muscle	0.85950833
69	MP0003950_abnormal_plasma_membrane	0.85585757
70	MP0008438_abnormal_cutaneous_collagen	0.83509698
71	MP0005584_abnormal_enzyme/coenzyme_acti	0.82260579
72	MP0005620_abnormal_muscle_contractility	0.79854054
73	MP0009840_abnormal_foam_cell	0.79533719
74	MP0002269_muscular_atrophy	0.78044221
75	MP0000767_abnormal_smooth_muscle	0.77228288
76	MP0002108_abnormal_muscle_morphology	0.75474014
77	MP0002933_joint_inflammation	0.73595585
78	MP0003123_paternal_imprinting	0.71710485
79	MP0004484_altered_response_of	0.71085698
80	MP0001879_abnormal_lymphatic_vessel	0.69124910
81	MP0002106_abnormal_muscle_physiology	0.69089498
82	MP0000598_abnormal_liver_morphology	0.68944087
83	MP0010630_abnormal_cardiac_muscle	0.66863267
84	MP0005369_muscle_phenotype	0.65639107
85	MP0003953_abnormal_hormone_level	0.63871624
86	MP0003948_abnormal_gas_homeostasis	0.63622325
87	MP0004019_abnormal_vitamin_homeostasis	0.61040154
88	MP0003724_increased_susceptibility_to	0.60779684
89	MP0009780_abnormal_chondrocyte_physiolo	0.60362484
90	MP0005376_homeostasis/metabolism_phenot	0.56857356
91	MP0008872_abnormal_physiological_respon	0.55646202
92	MP0005367_renal/urinary_system_phenotyp	0.52135334
93	MP0000516_abnormal_urinary_system	0.52135334
94	MP0005319_abnormal_enzyme/_coenzyme	0.49542004
95	MP0004885_abnormal_endolymph	0.48395280
96	MP0009384_cardiac_valve_regurgitation	0.47553705
97	MP0005647_abnormal_sex_gland	0.46088372
98	MP0000230_abnormal_systemic_arterial	0.45999371
99	MP0003638_abnormal_response/metabolism_	0.45755634
100	MP0005595_abnormal_vascular_smooth	0.45205659

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperlipoproteinemia (HP:0010980)	5.46832967
2	Epidermoid cyst (HP:0200040)	4.75818254
3	Xanthomatosis (HP:0000991)	4.68526368
4	Hypertriglyceridemia (HP:0002155)	4.29219700
5	Increased muscle lipid content (HP:0009058)	4.17543206
6	Deep venous thrombosis (HP:0002625)	4.13003524
7	Oligomenorrhea (HP:0000876)	4.10963283
8	Acanthosis nigricans (HP:0000956)	4.01504562
9	Complement deficiency (HP:0004431)	3.96351104
10	Skin nodule (HP:0200036)	3.82829972
11	Rhabdomyolysis (HP:0003201)	3.78587542
12	Hypercholesterolemia (HP:0003124)	3.77960047
13	Increased serum pyruvate (HP:0003542)	3.76928653
14	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.72611820
15	Myoglobinuria (HP:0002913)	3.50036166
16	Hemorrhage of the eye (HP:0011885)	3.49780090
17	Increased variability in muscle fiber diameter (HP:0003557)	3.47052486
18	Back pain (HP:0003418)	3.43701913
19	Abnormality of complement system (HP:0005339)	3.39712579
20	Joint hemorrhage (HP:0005261)	3.38067780
21	Abnormality of glycolysis (HP:0004366)	3.31899133
22	Protrusio acetabuli (HP:0003179)	3.25536571
23	Prolonged partial thromboplastin time (HP:0003645)	3.20133027
24	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.18830168
25	Myocardial infarction (HP:0001658)	3.16466312
26	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.04167337
27	Abnormality of skeletal muscle fiber size (HP:0012084)	2.97887074
28	Muscle fiber splitting (HP:0003555)	2.92300370
29	Asymmetric septal hypertrophy (HP:0001670)	2.87807337
30	Increased intramyocellular lipid droplets (HP:0012240)	2.85706830
31	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.83288237
32	Difficulty running (HP:0009046)	2.81901874
33	Lipoatrophy (HP:0100578)	2.80308076
34	Esophageal varix (HP:0002040)	2.80276167
35	Insulin resistance (HP:0000855)	2.71998816
36	Infantile muscular hypotonia (HP:0008947)	2.68515493
37	Abnormality of fatty-acid metabolism (HP:0004359)	2.64302712
38	Renal Fanconi syndrome (HP:0001994)	2.59388320
39	Increased connective tissue (HP:0009025)	2.58328927
40	Exercise-induced myalgia (HP:0003738)	2.47920887
41	Mesangial abnormality (HP:0001966)	2.45562250
42	Hyporeflexia of lower limbs (HP:0002600)	2.44946040
43	Systemic lupus erythematosus (HP:0002725)	2.41249245
44	Generalized hyperpigmentation (HP:0007440)	2.38580806
45	Sudden death (HP:0001699)	2.38160011
46	Adactyly (HP:0009776)	2.28212999
47	Pigmentary retinal degeneration (HP:0001146)	2.26320948
48	Insulin-resistant diabetes mellitus (HP:0000831)	2.22311482
49	Dilated cardiomyopathy (HP:0001644)	2.22067247
50	Retinal atrophy (HP:0001105)	2.21231227
51	Porencephaly (HP:0002132)	2.18839136
52	Abnormality of the prostate (HP:0008775)	2.15667739
53	Neck muscle weakness (HP:0000467)	2.15099768
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14883943
55	Abnormality of alanine metabolism (HP:0010916)	2.14883943
56	Hyperalaninemia (HP:0003348)	2.14883943
57	Spinal rigidity (HP:0003306)	2.13168869
58	Nausea (HP:0002018)	2.09445375
59	Mitral stenosis (HP:0001718)	2.08967853
60	Tubulointerstitial fibrosis (HP:0005576)	2.07678118
61	Absent hand (HP:0004050)	2.06944066
62	Hyperkalemia (HP:0002153)	2.06311924
63	Thin skin (HP:0000963)	2.01852324
64	Pancreatitis (HP:0001733)	2.01470399
65	Type 1 muscle fiber predominance (HP:0003803)	1.98441189
66	Increased hepatocellular lipid droplets (HP:0006565)	1.96304007
67	Hepatosplenomegaly (HP:0001433)	1.96063256
68	Exertional dyspnea (HP:0002875)	1.95909576
69	Glomerulonephritis (HP:0000099)	1.94880472
70	Hypobetalipoproteinemia (HP:0003563)	1.93881626
71	Cutaneous photosensitivity (HP:0000992)	1.93764973
72	Vertebral compression fractures (HP:0002953)	1.93710732
73	Lipid accumulation in hepatocytes (HP:0006561)	1.92344708
74	Thrombophlebitis (HP:0004418)	1.89359779
75	Abnormality of chloride homeostasis (HP:0011422)	1.88036430
76	Dicarboxylic aciduria (HP:0003215)	1.87776676
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87776676
78	Bundle branch block (HP:0011710)	1.86960080
79	Atrioventricular block (HP:0001678)	1.86860187
80	Delayed CNS myelination (HP:0002188)	1.85478121
81	Abnormality of the common coagulation pathway (HP:0010990)	1.81818580
82	Menorrhagia (HP:0000132)	1.80152634
83	Portal hypertension (HP:0001409)	1.79996756
84	Fat malabsorption (HP:0002630)	1.79823614
85	Increased mean platelet volume (HP:0011877)	1.79398242
86	Psychosis (HP:0000709)	1.77950332
87	Coronal craniosynostosis (HP:0004440)	1.77855906
88	Abnormality of the intrinsic pathway (HP:0010989)	1.77229251
89	Skull defect (HP:0001362)	1.76829554
90	Steatorrhea (HP:0002570)	1.76757752
91	Abnormal atrioventricular conduction (HP:0005150)	1.75208132
92	Hyperphosphaturia (HP:0003109)	1.74759148
93	Glycosuria (HP:0003076)	1.74585775
94	Abnormality of urine glucose concentration (HP:0011016)	1.74585775
95	Pancreatic islet-cell hyperplasia (HP:0004510)	1.73998700
96	Abnormality of the calf musculature (HP:0001430)	1.73667895
97	Abnormality of vitamin metabolism (HP:0100508)	1.73658602
98	Hypolipoproteinemia (HP:0010981)	1.73652199
99	Prominent supraorbital ridges (HP:0000336)	1.73557990
100	Generalized aminoaciduria (HP:0002909)	1.73528095

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	7.53171417
2	NEK2	6.77352825
3	CAMK1D	4.78110677
4	CAMKK2	4.77478588
5	CAMK1G	3.16506372
6	ERN1	3.05262877
7	SMG1	2.53453905
8	TAF1	2.44168821
9	VRK2	2.27143862
10	TIE1	2.07320122
11	CAMK1	2.04281276
12	PRKAA2	1.88291077
13	EPHB2	1.87983828
14	TRIB3	1.83747012
15	MAP3K7	1.78526148
16	WNK4	1.73417194
17	MYLK	1.71152233
18	LRRK2	1.68219567
19	CAMKK1	1.56621695
20	TTN	1.46287155
21	TESK1	1.37307816
22	OBSCN	1.35040130
23	GRK5	1.13243294
24	CHUK	1.13099388
25	RIPK1	1.11782326
26	EPHA3	1.05261122
27	MAPK4	1.03857977
28	TGFBR2	1.02676145
29	PRPF4B	0.94710217
30	ICK	0.87703426
31	DDR2	0.87562951
32	MARK2	0.83365884
33	ABL2	0.81929768
34	PDGFRB	0.81429987
35	MAPKAPK5	0.78535378
36	NEK9	0.77318288
37	PRKAA1	0.73763012
38	CAMK4	0.71756078
39	TESK2	0.70456406
40	PAK2	0.67005237
41	FGFR4	0.65409982
42	PRKD1	0.63175457
43	WNK1	0.59234170
44	HIPK2	0.57114701
45	SIK1	0.55461624
46	PDGFRA	0.55375485
47	CSK	0.53530295
48	IRAK3	0.52676998
49	PDPK1	0.49985879
50	TYRO3	0.46572490
51	GRK1	0.44684236
52	DAPK3	0.44619280
53	LATS2	0.42529767
54	CDK9	0.42425769
55	MAP3K6	0.39565501
56	TRPM7	0.38689224
57	PAK4	0.37407101
58	PIK3CA	0.36612639
59	LIMK1	0.36171914
60	PHKG2	0.36106088
61	PHKG1	0.36106088
62	GSK3A	0.35694329
63	MAP3K3	0.35134691
64	PRKG1	0.33784643
65	DYRK1A	0.33414969
66	EPHB1	0.32783059
67	PRKACG	0.32317654
68	CDC42BPA	0.29078361
69	PTK2B	0.27165886
70	MELK	0.26845440
71	SGK2	0.25164131
72	MAPK12	0.25039468
73	FGFR3	0.24347781
74	MAP2K1	0.22528617
75	LMTK2	0.22064417
76	CAMK2D	0.21587911
77	MTOR	0.21214052
78	NUAK1	0.20680971
79	FER	0.20454981
80	PTK2	0.19983943
81	EIF2AK2	0.19980091
82	SGK223	0.19503813
83	SGK494	0.19503813
84	IGF1R	0.19161304
85	ERBB4	0.18530193
86	MOS	0.18307278
87	PRKACA	0.16031887
88	RPS6KA3	0.15030173
89	PDK1	0.13512832
90	PDK2	0.13416231
91	PKN1	0.13378704
92	PRKCE	0.12971996
93	PRKACB	0.12770099
94	PIK3CG	0.12706515
95	PAK3	0.11530029
96	MAPKAPK3	0.09952970
97	SGK3	0.09009967
98	DYRK3	0.08886869
99	ADRBK1	0.08780741
100	AKT1	0.08630942

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	PPAR signaling pathway_Homo sapiens_hsa03320	3.63038320
2	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.36814969
3	Phenylalanine metabolism_Homo sapiens_hsa00360	3.17327438
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.05672205
5	Fatty acid degradation_Homo sapiens_hsa00071	2.96689285
6	Caffeine metabolism_Homo sapiens_hsa00232	2.75459024
7	Propanoate metabolism_Homo sapiens_hsa00640	2.73744380
8	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.64050048
9	Glycerolipid metabolism_Homo sapiens_hsa00561	2.39841509
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.32090752
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.27129150
12	Histidine metabolism_Homo sapiens_hsa00340	2.24838120
13	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.15276669
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.10120915
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.07155855
16	beta-Alanine metabolism_Homo sapiens_hsa00410	2.05236504
17	Fatty acid elongation_Homo sapiens_hsa00062	2.01169257
18	Fatty acid metabolism_Homo sapiens_hsa01212	2.01099669
19	Tyrosine metabolism_Homo sapiens_hsa00350	1.97505301
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.94037735
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.92616205
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.92019474
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.87376022
24	Renin-angiotensin system_Homo sapiens_hsa04614	1.86872663
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83549233
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.78751875
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.62956282
28	Retinol metabolism_Homo sapiens_hsa00830	1.61497851
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.59145986
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57908300
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.54268854
32	Butanoate metabolism_Homo sapiens_hsa00650	1.43424558
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37879150
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.37225186
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34801484
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.33431945
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.33214554
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31745953
39	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.29548174
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.27198903
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22736022
42	AMPK signaling pathway_Homo sapiens_hsa04152	1.14834275
43	Arginine biosynthesis_Homo sapiens_hsa00220	1.14226840
44	Carbon metabolism_Homo sapiens_hsa01200	1.12634718
45	Arginine and proline metabolism_Homo sapiens_hsa00330	1.10361324
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.05724415
47	Peroxisome_Homo sapiens_hsa04146	1.04528401
48	ECM-receptor interaction_Homo sapiens_hsa04512	0.97664095
49	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.92792338
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91446081
51	Bile secretion_Homo sapiens_hsa04976	0.87907489
52	Lysine degradation_Homo sapiens_hsa00310	0.87058005
53	Sulfur metabolism_Homo sapiens_hsa00920	0.82056348
54	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.80667099
55	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72767671
56	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68659263
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65803764
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63406637
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61637546
60	Sulfur relay system_Homo sapiens_hsa04122	0.60468566
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.59155901
62	Glutathione metabolism_Homo sapiens_hsa00480	0.59026138
63	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.56109463
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55882295
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.51819321
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.50677612
67	ABC transporters_Homo sapiens_hsa02010	0.48026493
68	Folate biosynthesis_Homo sapiens_hsa00790	0.45756673
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.44087828
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43669119
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43067070
72	Insulin resistance_Homo sapiens_hsa04931	0.42066639
73	Focal adhesion_Homo sapiens_hsa04510	0.41614636
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41097406
75	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.40258775
76	Insulin signaling pathway_Homo sapiens_hsa04910	0.38137163
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37252932
78	Metabolic pathways_Homo sapiens_hsa01100	0.34045275
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32109645
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31231714
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28773534
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25367362
83	Galactose metabolism_Homo sapiens_hsa00052	0.24308170
84	Nitrogen metabolism_Homo sapiens_hsa00910	0.24207360
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.22908665
86	Renin secretion_Homo sapiens_hsa04924	0.22372496
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.21223842
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.17843531
89	Amoebiasis_Homo sapiens_hsa05146	0.13884131
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.13718236
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.09836360
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.09031296
93	Lysosome_Homo sapiens_hsa04142	0.04351519
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.04098909
95	Axon guidance_Homo sapiens_hsa04360	0.02999475
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.02496268
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.01247482
98	Cocaine addiction_Homo sapiens_hsa05030	0.01148412
99	Mineral absorption_Homo sapiens_hsa04978	0.00944818
100	Proteoglycans in cancer_Homo sapiens_hsa05205	0.00304579

AQP7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »