AQP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)9.81996016
2sulfate transport (GO:0008272)8.20664094
3bicarbonate transport (GO:0015701)7.74332661
4intestinal absorption (GO:0050892)7.40971164
5positive regulation of fatty acid beta-oxidation (GO:0032000)7.20741088
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.15167665
7L-phenylalanine catabolic process (GO:0006559)7.15167665
8sperm capacitation (GO:0048240)7.14468613
9positive regulation of respiratory burst (GO:0060267)6.86830656
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.85766321
11L-phenylalanine metabolic process (GO:0006558)6.85766321
12renal system process involved in regulation of blood volume (GO:0001977)6.57423715
13regulation of guanylate cyclase activity (GO:0031282)6.55655244
14glucocorticoid biosynthetic process (GO:0006704)6.46923576
15aromatic amino acid family catabolic process (GO:0009074)6.41825486
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.36435306
17flavonoid metabolic process (GO:0009812)6.34640191
18positive regulation of synaptic transmission, GABAergic (GO:0032230)5.98274502
19oligosaccharide biosynthetic process (GO:0009312)5.97526735
20sulfur amino acid catabolic process (GO:0000098)5.80155245
21tryptophan catabolic process (GO:0006569)5.79479989
22indole-containing compound catabolic process (GO:0042436)5.79479989
23indolalkylamine catabolic process (GO:0046218)5.79479989
24kynurenine metabolic process (GO:0070189)5.73453127
25positive regulation of fatty acid oxidation (GO:0046321)5.66666926
26alpha-linolenic acid metabolic process (GO:0036109)5.66224476
27bile acid biosynthetic process (GO:0006699)5.55736435
28high-density lipoprotein particle remodeling (GO:0034375)5.52689533
29one-carbon metabolic process (GO:0006730)5.48364423
30tryptophan metabolic process (GO:0006568)5.44300016
31bundle of His cell to Purkinje myocyte communication (GO:0086069)5.43916701
32glyoxylate metabolic process (GO:0046487)5.41454959
33regulation of intracellular pH (GO:0051453)5.37141945
34negative regulation of fibrinolysis (GO:0051918)5.36148676
35regulation of respiratory burst (GO:0060263)5.36116568
36cysteine metabolic process (GO:0006534)5.28508560
37calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.28327139
38regulation of vitamin metabolic process (GO:0030656)5.22963709
39urea metabolic process (GO:0019627)5.14194493
40urea cycle (GO:0000050)5.14194493
41regulation of fibrinolysis (GO:0051917)5.09833522
42protein carboxylation (GO:0018214)5.08892322
43peptidyl-glutamic acid carboxylation (GO:0017187)5.08892322
44receptor guanylyl cyclase signaling pathway (GO:0007168)5.06606642
45regulation of protein activation cascade (GO:2000257)5.03282803
46glomerular filtration (GO:0003094)4.98875337
47regulation of cellular pH (GO:0030641)4.97808552
48complement activation, alternative pathway (GO:0006957)4.94504722
49serine family amino acid catabolic process (GO:0009071)4.90872075
50regulation of cholesterol esterification (GO:0010872)4.90758085
51bile acid metabolic process (GO:0008206)4.90652888
52reverse cholesterol transport (GO:0043691)4.83467022
53phospholipid efflux (GO:0033700)4.78671070
54regulation of triglyceride catabolic process (GO:0010896)4.74716139
55nitrogen cycle metabolic process (GO:0071941)4.71697042
56renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.71138393
57protein-lipid complex remodeling (GO:0034368)4.70581150
58macromolecular complex remodeling (GO:0034367)4.70581150
59plasma lipoprotein particle remodeling (GO:0034369)4.70581150
60* bile acid and bile salt transport (GO:0015721)4.70174465
61regulation of complement activation (GO:0030449)4.69876692
62aromatic amino acid family metabolic process (GO:0009072)4.67374475
63negative regulation of myotube differentiation (GO:0010832)4.65708029
64homocysteine metabolic process (GO:0050667)4.65489154
65negative regulation of sterol transport (GO:0032372)4.64277408
66negative regulation of cholesterol transport (GO:0032375)4.64277408
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.63158558
68cGMP-mediated signaling (GO:0019934)4.62466177
69regulation of fatty acid beta-oxidation (GO:0031998)4.61911294
70ethanol metabolic process (GO:0006067)4.60907036
71renal filtration (GO:0097205)4.54976029
72triglyceride homeostasis (GO:0070328)4.53786420
73acylglycerol homeostasis (GO:0055090)4.53786420
74purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.51781143
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.51781143
76positive regulation of systemic arterial blood pressure (GO:0003084)4.51187480
77amino-acid betaine metabolic process (GO:0006577)4.50212023
78cellular ketone body metabolic process (GO:0046950)4.41454596
79tyrosine metabolic process (GO:0006570)4.40313795
80desmosome organization (GO:0002934)4.38432806
81sulfur compound transport (GO:0072348)4.38099214
82plasma lipoprotein particle clearance (GO:0034381)4.37849559
83alpha-amino acid catabolic process (GO:1901606)4.37035248
84regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.34057801
85endocrine process (GO:0050886)4.34057801
86regulation of systemic arterial blood pressure by hormone (GO:0001990)4.34057801
87lysine metabolic process (GO:0006553)4.32414635
88lysine catabolic process (GO:0006554)4.32414635
89regulation of pH (GO:0006885)4.27381329
90cellular glucuronidation (GO:0052695)4.24910241
91glycine metabolic process (GO:0006544)4.20501352
92labyrinthine layer development (GO:0060711)4.18674428
93ethanol oxidation (GO:0006069)4.15193949
94cholesterol efflux (GO:0033344)4.12217604
95cellular amino acid catabolic process (GO:0009063)4.10745382
96indolalkylamine metabolic process (GO:0006586)4.08188342
97phospholipid homeostasis (GO:0055091)4.04504845
98coenzyme catabolic process (GO:0009109)4.04496156
99imidazole-containing compound metabolic process (GO:0052803)4.03792071
100plasma lipoprotein particle assembly (GO:0034377)4.03625892
101cellular response to pH (GO:0071467)4.02058464
102nucleoside diphosphate biosynthetic process (GO:0009133)4.01321407
103serine family amino acid metabolic process (GO:0009069)3.99970051
104amine catabolic process (GO:0009310)3.99682289
105cellular biogenic amine catabolic process (GO:0042402)3.99682289
106glutamate metabolic process (GO:0006536)3.99366489
107cellular modified amino acid catabolic process (GO:0042219)3.99315704
108benzene-containing compound metabolic process (GO:0042537)3.98450513
109regulation of cGMP biosynthetic process (GO:0030826)3.95557598
110drug catabolic process (GO:0042737)3.93911651
111low-density lipoprotein particle remodeling (GO:0034374)3.91068710
112serine family amino acid biosynthetic process (GO:0009070)3.88532922
113pyrimidine-containing compound transmembrane transport (GO:0072531)3.84747221
114positive regulation of pseudopodium assembly (GO:0031274)3.84185011
115maintenance of gastrointestinal epithelium (GO:0030277)3.83697658
116fibrinolysis (GO:0042730)3.83144692
117positive regulation of triglyceride lipase activity (GO:0061365)3.82146475
118positive regulation of lipoprotein lipase activity (GO:0051006)3.82146475
119ketone body metabolic process (GO:1902224)3.81678319
120short-chain fatty acid metabolic process (GO:0046459)3.80518748
121cellular monovalent inorganic cation homeostasis (GO:0030004)3.77548414
122cholesterol homeostasis (GO:0042632)3.76345336
123positive regulation of guanylate cyclase activity (GO:0031284)3.76239056
124transcytosis (GO:0045056)3.76099935
125uronic acid metabolic process (GO:0006063)3.75201753
126glucuronate metabolic process (GO:0019585)3.75201753
127dicarboxylic acid biosynthetic process (GO:0043650)3.74262659
128negative regulation of leukocyte chemotaxis (GO:0002689)3.74171378
129response to food (GO:0032094)3.72804076
130very-low-density lipoprotein particle assembly (GO:0034379)3.72642049
131actin filament depolymerization (GO:0030042)3.72454783
132regulation of cholesterol homeostasis (GO:2000188)3.71714698
133positive regulation of lipid catabolic process (GO:0050996)3.71437213
134sterol homeostasis (GO:0055092)3.70406942
135arginine metabolic process (GO:0006525)3.69719099
136excretion (GO:0007588)3.69354367
137O-glycan processing (GO:0016266)3.68143357
138monovalent inorganic cation homeostasis (GO:0055067)3.67910407
139opsonization (GO:0008228)3.67571585
140blood coagulation, intrinsic pathway (GO:0007597)3.63793979
141aldehyde catabolic process (GO:0046185)3.63732128
142protein-lipid complex assembly (GO:0065005)3.63418195
143regulation of systemic arterial blood pressure (GO:0003073)3.62913926
144phenylpropanoid metabolic process (GO:0009698)3.62460664
145negative regulation of lipase activity (GO:0060192)3.62410013
146organic acid catabolic process (GO:0016054)3.61952922
147carboxylic acid catabolic process (GO:0046395)3.61952922
148UDP-N-acetylglucosamine metabolic process (GO:0006047)3.59257106
149response to acidic pH (GO:0010447)3.58392417
150plasma lipoprotein particle organization (GO:0071827)3.56789560
151acetyl-CoA metabolic process (GO:0006084)3.56220718
152thrombin receptor signaling pathway (GO:0070493)3.56086182
153purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.53173924
154ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.53173924
155nucleoside bisphosphate biosynthetic process (GO:0033866)3.53173924
156protein activation cascade (GO:0072376)3.52781766
157nucleotide-sugar biosynthetic process (GO:0009226)3.52578478
158intestinal cholesterol absorption (GO:0030299)3.52402081
159complement activation, classical pathway (GO:0006958)3.51171311
160glucocorticoid metabolic process (GO:0008211)3.50848781
161nicotinamide nucleotide biosynthetic process (GO:0019359)3.50403236
162pyridine nucleotide biosynthetic process (GO:0019363)3.50403236
163digestive system process (GO:0022600)3.49268511
164NAD biosynthetic process (GO:0009435)3.48503469
165acute-phase response (GO:0006953)3.47148428
166regulation of pseudopodium assembly (GO:0031272)3.43521111
167sodium ion homeostasis (GO:0055078)3.43352064
168drug transmembrane transport (GO:0006855)3.41695176
169regulation of fatty acid oxidation (GO:0046320)3.31945597
170GDP-mannose metabolic process (GO:0019673)3.31191942
171fucosylation (GO:0036065)3.30433129
172intermediate filament organization (GO:0045109)3.29227213
173regulation of cGMP metabolic process (GO:0030823)3.25301944
174intestinal epithelial cell development (GO:0060576)3.23637600
175negative regulation of protein tyrosine kinase activity (GO:0061099)3.21535370
176activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.21094411
177regulation of viral release from host cell (GO:1902186)3.18052966
178regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13071746
179positive regulation of Cdc42 GTPase activity (GO:0043089)3.08977306
180membrane hyperpolarization (GO:0060081)3.05101024
181auditory receptor cell differentiation (GO:0042491)3.04192742
182drug transport (GO:0015893)3.02077947
183negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.01684419
184inorganic anion transmembrane transport (GO:0098661)2.97530452
185chloride transmembrane transport (GO:1902476)2.96513092
186regulation of protein glycosylation (GO:0060049)2.96391145
187response to pH (GO:0009268)2.95927712
188regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.93321357
189epoxygenase P450 pathway (GO:0019373)2.89543612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.01488378
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00411362
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.62876914
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.20208216
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.92322345
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.77901239
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74154084
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.73433956
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.67048237
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.49247778
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.53472327
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46733980
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46222792
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.27636654
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07205440
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5269391
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92841641
18DROSHA_22980978_ChIP-Seq_HELA_Human1.89496922
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83625628
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83384822
21CLOCK_20551151_ChIP-Seq_293T_Human1.78763284
22KLF5_25053715_ChIP-Seq_YYC3_Human1.73767012
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.62458864
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.56040525
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.55908017
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54583531
27CDX2_22108803_ChIP-Seq_LS180_Human1.48924701
28P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48274560
29HTT_18923047_ChIP-ChIP_STHdh_Human1.43626592
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42918452
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38153723
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38070616
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36841287
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35641480
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34586061
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29189293
37JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.29016536
38* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28706336
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28511331
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27841553
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27519004
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25203420
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24514221
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.24155791
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21646214
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.21512562
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20026746
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17136671
49RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15221771
50GATA4_25053715_ChIP-Seq_YYC3_Human1.14714610
51SA1_27219007_Chip-Seq_Bcells_Human1.14301324
52E2F1_20622854_ChIP-Seq_HELA_Human1.10989959
53STAT1_20625510_ChIP-Seq_HELA_Human1.06784396
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05026147
55GATA1_22025678_ChIP-Seq_K562_Human1.02764245
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02338269
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00180526
58ESR2_21235772_ChIP-Seq_MCF-7_Human0.99315513
59* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99221329
60TP63_22573176_ChIP-Seq_HFKS_Human0.98322453
61TP63_17297297_ChIP-ChIP_HaCaT_Human0.98215806
62ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97578194
63* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95844872
64BCL6_27268052_Chip-Seq_Bcells_Human0.95408914
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94666724
66CREB1_26743006_Chip-Seq_LNCaP_Human0.94572827
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94555829
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93939515
69ZNF263_19887448_ChIP-Seq_K562_Human0.91026733
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89487557
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89222079
72* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86613153
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85771159
74NANOG_20526341_ChIP-Seq_ESCs_Human0.84364750
75CDX2_20551321_ChIP-Seq_CACO-2_Human0.84329934
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84305698
77AR_21909140_ChIP-Seq_LNCAP_Human0.84042127
78RARA_24833708_ChIP-Seq_LIVER_Mouse0.82646627
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81709729
80CTCF_20526341_ChIP-Seq_ESCs_Human0.81507858
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81260426
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81219754
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80966246
84* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79185514
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79037132
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78789822
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78637488
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77263483
89SOX2_20726797_ChIP-Seq_SW620_Human0.76478245
90* ETS1_21867929_ChIP-Seq_TH2_Mouse0.76415495
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75695920
92GATA6_25053715_ChIP-Seq_YYC3_Human0.74562177
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74510768
94LXR_22292898_ChIP-Seq_THP-1_Human0.74000123
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73626950
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72885693
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71982662
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71724320
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71658579
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.71290497
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.70539802
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.69897932
103* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69236547
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.68961086
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68789809
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67278728
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67160293
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.66399021
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.66386793
110EGR1_19032775_ChIP-ChIP_M12_Human0.65797672
111MYC_19915707_ChIP-ChIP_AK7_Human0.64898283
112IRF8_22096565_ChIP-ChIP_GC-B_Human0.64601731
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63401012
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63401012
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62948099
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61439051
117RACK7_27058665_Chip-Seq_MCF-7_Human0.61077564
118TAF2_19829295_ChIP-Seq_ESCs_Human0.60872195
119CEBPB_22108803_ChIP-Seq_LS180_Human0.59685056
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57005804
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56373945
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.55947077
123P53_21459846_ChIP-Seq_SAOS-2_Human0.55606816
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53245154
125BCOR_27268052_Chip-Seq_Bcells_Human0.52156631
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.51710918
127* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49673623
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48703284
129* GATA2_19941826_ChIP-Seq_K562_Human0.47851829
130* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.47112273
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.46679133
132* GATA1_19941827_ChIP-Seq_MEL_Mouse0.46525237
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45629481
134* GATA1_19941826_ChIP-Seq_K562_Human0.45628499
135STAT1_17558387_ChIP-Seq_HELA_Human0.45018834
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.44828978
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.44219748
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.44057365
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.43858132
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.43643108
141SOX2_22085726_ChIP-Seq_NPCs_Mouse0.42257949
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41793557
143CTCF_27219007_Chip-Seq_Bcells_Human0.40459545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10648760
2MP0005360_urolithiasis6.96512756
3MP0005085_abnormal_gallbladder_physiolo6.28669533
4MP0005365_abnormal_bile_salt6.07960251
5MP0008875_abnormal_xenobiotic_pharmacok5.19245142
6MP0004043_abnormal_pH_regulation5.18179989
7MP0003806_abnormal_nucleotide_metabolis4.31516800
8MP0003866_abnormal_defecation4.06955904
9MP0003252_abnormal_bile_duct3.88386784
10MP0010352_gastrointestinal_tract_polyps3.83952086
11MP0010329_abnormal_lipoprotein_level3.52630593
12MP0009840_abnormal_foam_cell3.20569914
13MP0005083_abnormal_biliary_tract3.14611084
14MP0001666_abnormal_nutrient_absorption3.11375089
15MP0001663_abnormal_digestive_system2.98419245
16MP0000490_abnormal_crypts_of2.72623940
17MP0000477_abnormal_intestine_morphology2.63061935
18MP0005381_digestive/alimentary_phenotyp2.60821245
19MP0005332_abnormal_amino_acid2.54909153
20MP0004147_increased_porphyrin_level2.44264855
21MP0009379_abnormal_foot_pigmentation2.38748085
22MP0004019_abnormal_vitamin_homeostasis2.38671241
23MP0003195_calcinosis2.35937456
24MP0001664_abnormal_digestion2.35590901
25MP0003191_abnormal_cellular_cholesterol2.34591989
26MP0001873_stomach_inflammation2.31600243
27MP0010155_abnormal_intestine_physiology2.25717975
28MP0000609_abnormal_liver_physiology2.06517453
29* MP0002118_abnormal_lipid_homeostasis2.05889247
30MP0003868_abnormal_feces_composition2.03447415
31MP0010234_abnormal_vibrissa_follicle1.82319792
32MP0002009_preneoplasia1.81425308
33MP0002138_abnormal_hepatobiliary_system1.79795622
34MP0005319_abnormal_enzyme/_coenzyme1.74152115
35MP0005451_abnormal_body_composition1.56486703
36MP0005584_abnormal_enzyme/coenzyme_acti1.53089395
37MP0000678_abnormal_parathyroid_gland1.46502485
38MP0000467_abnormal_esophagus_morphology1.46436294
39MP0002098_abnormal_vibrissa_morphology1.45735430
40MP0001764_abnormal_homeostasis1.43433627
41MP0009643_abnormal_urine_homeostasis1.38415079
42MP0003705_abnormal_hypodermis_morpholog1.35477920
43MP0003303_peritoneal_inflammation1.33051291
44MP0003693_abnormal_embryo_hatching1.31385776
45MP0000462_abnormal_digestive_system1.30672367
46MP0000604_amyloidosis1.28806066
47MP0003011_delayed_dark_adaptation1.28230297
48MP0009697_abnormal_copulation1.27548636
49MP0005501_abnormal_skin_physiology1.22336535
50MP0002254_reproductive_system_inflammat1.21377973
51MP0003567_abnormal_fetal_cardiomyocyte1.21304751
52MP0005636_abnormal_mineral_homeostasis1.17738604
53MP0003186_abnormal_redox_activity1.12716133
54MP0005409_darkened_coat_color1.11850371
55MP0000598_abnormal_liver_morphology1.10754983
56MP0009053_abnormal_anal_canal1.10317432
57MP0000537_abnormal_urethra_morphology1.09311956
58MP0005647_abnormal_sex_gland1.09310414
59MP0005310_abnormal_salivary_gland1.07709144
60MP0003183_abnormal_peptide_metabolism1.07567457
61MP0000566_synostosis1.07378837
62MP0003656_abnormal_erythrocyte_physiolo1.04156837
63MP0000470_abnormal_stomach_morphology1.00677537
64MP0003879_abnormal_hair_cell0.96877403
65MP0005084_abnormal_gallbladder_morpholo0.96577504
66MP0002166_altered_tumor_susceptibility0.94425650
67MP0009764_decreased_sensitivity_to0.94148334
68MP0002822_catalepsy0.94051831
69MP0005257_abnormal_intraocular_pressure0.92612440
70MP0002006_tumorigenesis0.90231857
71MP0002132_abnormal_respiratory_system0.89157926
72MP0003300_gastrointestinal_ulcer0.88656812
73MP0009785_altered_susceptibility_to0.87798714
74MP0009763_increased_sensitivity_to0.86734415
75MP0003329_amyloid_beta_deposits0.84818977
76MP0005165_increased_susceptibility_to0.84515925
77* MP0009642_abnormal_blood_homeostasis0.84477147
78MP0005408_hypopigmentation0.82561186
79MP0010678_abnormal_skin_adnexa0.82171392
80MP0001849_ear_inflammation0.82107917
81MP0005220_abnormal_exocrine_pancreas0.81682524
82MP0010368_abnormal_lymphatic_system0.80809729
83MP0001756_abnormal_urination0.80752678
84MP0008469_abnormal_protein_level0.80599375
85MP0001727_abnormal_embryo_implantation0.80280557
86MP0002876_abnormal_thyroid_physiology0.79091204
87MP0000465_gastrointestinal_hemorrhage0.79074169
88MP0001188_hyperpigmentation0.78306146
89MP0005376_homeostasis/metabolism_phenot0.75664291
90MP0006036_abnormal_mitochondrial_physio0.75048055
91MP0001216_abnormal_epidermal_layer0.72239874
92MP0005058_abnormal_lysosome_morphology0.71925334
93MP0004484_altered_response_of0.69964572
94MP0002078_abnormal_glucose_homeostasis0.69891533
95MP0008004_abnormal_stomach_pH0.69867775
96MP0004185_abnormal_adipocyte_glucose0.69100392
97MP0009780_abnormal_chondrocyte_physiolo0.68183579
98MP0001661_extended_life_span0.67239136
99MP0000377_abnormal_hair_follicle0.66090758
100MP0005670_abnormal_white_adipose0.64367269
101MP0006035_abnormal_mitochondrial_morpho0.63400190
102MP0009765_abnormal_xenobiotic_induced0.63362555
103MP0002796_impaired_skin_barrier0.62546237
104MP0002971_abnormal_brown_adipose0.62302518
105MP0005334_abnormal_fat_pad0.62130423
106MP0002896_abnormal_bone_mineralization0.60121581
107MP0004130_abnormal_muscle_cell0.59371764
108MP0005266_abnormal_metabolism0.58631223
109MP0000639_abnormal_adrenal_gland0.57570824
110MP0005025_abnormal_response_to0.56749118
111MP0009333_abnormal_splenocyte_physiolog0.55976983
112MP0005167_abnormal_blood-brain_barrier0.54917963
113MP0005448_abnormal_energy_balance0.54418982
114MP0002136_abnormal_kidney_physiology0.53743992
115MP0003283_abnormal_digestive_organ0.53730293
116MP0004264_abnormal_extraembryonic_tissu0.52943246
117MP0003315_abnormal_perineum_morphology0.51703105
118MP0003638_abnormal_response/metabolism_0.51321578
119MP0003690_abnormal_glial_cell0.51233733
120MP0002932_abnormal_joint_morphology0.50453542
121MP0002277_abnormal_respiratory_mucosa0.50260394
122MP0009115_abnormal_fat_cell0.50255536
123MP0001765_abnormal_ion_homeostasis0.50071320
124MP0002148_abnormal_hypersensitivity_rea0.48828615
125MP0005535_abnormal_body_temperature0.48174418
126MP0001485_abnormal_pinna_reflex0.48150696
127MP0003045_fibrosis0.44814286
128MP0009672_abnormal_birth_weight0.44783503
129MP0005595_abnormal_vascular_smooth0.44070818
130MP0005395_other_phenotype0.43998932
131MP0008873_increased_physiological_sensi0.43988420
132MP0005464_abnormal_platelet_physiology0.43749105
133MP0003953_abnormal_hormone_level0.43491937
134MP0009384_cardiac_valve_regurgitation0.43000567
135MP0002837_dystrophic_cardiac_calcinosis0.42602224
136MP0005375_adipose_tissue_phenotype0.41987763
137MP0000613_abnormal_salivary_gland0.41615205
138MP0002928_abnormal_bile_duct0.39760887
139MP0003718_maternal_effect0.39716607
140MP0004883_abnormal_blood_vessel0.39097012
141MP0005166_decreased_susceptibility_to0.39032280
142MP0008872_abnormal_physiological_respon0.38993711
143MP0008874_decreased_physiological_sensi0.37632021
144MP0004782_abnormal_surfactant_physiolog0.36368451
145MP0005666_abnormal_adipose_tissue0.35908198
146MP0000249_abnormal_blood_vessel0.34958527
147MP0005164_abnormal_response_to0.34552758
148MP0001881_abnormal_mammary_gland0.33761522
149MP0004947_skin_inflammation0.33193415
150MP0000230_abnormal_systemic_arterial0.32194584
151MP0003075_altered_response_to0.31950321
152MP0002060_abnormal_skin_morphology0.31652639
153MP0006082_CNS_inflammation0.30862949
154MP0003436_decreased_susceptibility_to0.30563686
155MP0002168_other_aberrant_phenotype0.29811093
156MP0001243_abnormal_dermal_layer0.29692945
157MP0003724_increased_susceptibility_to0.29678391
158MP0001845_abnormal_inflammatory_respons0.28970838
159MP0003453_abnormal_keratinocyte_physiol0.27452403

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)8.91898559
2Abnormality of renin-angiotensin system (HP:0000847)8.90999520
3Deep venous thrombosis (HP:0002625)7.20096805
4Intrahepatic cholestasis (HP:0001406)7.13142653
5Abnormality of chloride homeostasis (HP:0011422)6.97546202
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.91903900
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.40164852
8Flat acetabular roof (HP:0003180)6.39550797
9Hyperaldosteronism (HP:0000859)6.31783234
10Hypobetalipoproteinemia (HP:0003563)6.27111056
11Xanthomatosis (HP:0000991)6.20198119
12Prolonged partial thromboplastin time (HP:0003645)6.07624150
13Hyperlipoproteinemia (HP:0010980)5.75123835
14Hyponatremia (HP:0002902)5.42206117
15Hypokalemia (HP:0002900)4.88580106
16Complement deficiency (HP:0004431)4.82383114
17Hypolipoproteinemia (HP:0010981)4.75456430
18Neonatal short-limb short stature (HP:0008921)4.59282112
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46892325
20Abnormality of potassium homeostasis (HP:0011042)4.44180708
21Hyperglycinemia (HP:0002154)4.40755025
22Flat capital femoral epiphysis (HP:0003370)4.40321107
23Joint hemorrhage (HP:0005261)4.40006007
24Hyperammonemia (HP:0001987)4.38746577
25Flattened epiphyses (HP:0003071)4.31531009
26Hypoalphalipoproteinemia (HP:0003233)4.20425648
27Abnormality of the common coagulation pathway (HP:0010990)4.12145028
28Abdominal distention (HP:0003270)4.10482035
29Fat malabsorption (HP:0002630)4.10309356
30Abnormality of sodium homeostasis (HP:0010931)4.09042372
31Abnormality of the distal phalanx of the thumb (HP:0009617)4.06998178
32Epidermoid cyst (HP:0200040)4.05510757
33Hypoglycemic coma (HP:0001325)4.02203777
34Right ventricular cardiomyopathy (HP:0011663)3.97314976
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.96671407
36Ketosis (HP:0001946)3.93660921
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90398304
38Hyperglycinuria (HP:0003108)3.88775093
39Abnormality of methionine metabolism (HP:0010901)3.84764959
40Abnormality of glycine metabolism (HP:0010895)3.79663386
41Abnormality of serine family amino acid metabolism (HP:0010894)3.79663386
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74943769
43Conjugated hyperbilirubinemia (HP:0002908)3.68633310
44Hyperkalemia (HP:0002153)3.62792992
45Abnormality of the intrinsic pathway (HP:0010989)3.61056440
46Hypercholesterolemia (HP:0003124)3.58064828
47Abnormality of complement system (HP:0005339)3.49162807
48Spinal cord compression (HP:0002176)3.41240263
49Abnormality of pyrimidine metabolism (HP:0004353)3.32038770
50Malnutrition (HP:0004395)3.31503717
51Adrenal overactivity (HP:0002717)3.30048922
52Abnormality of fatty-acid metabolism (HP:0004359)3.28437614
53Hyperbilirubinemia (HP:0002904)3.27432837
54Visceral angiomatosis (HP:0100761)3.26217330
55Breech presentation (HP:0001623)3.19920305
56Ileus (HP:0002595)3.17921791
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17316230
58Steatorrhea (HP:0002570)3.03798786
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.96409453
60Vertebral hypoplasia (HP:0008417)2.96409453
61Hemangiomatosis (HP:0007461)2.94311093
62Pili torti (HP:0003777)2.92589994
63Abnormality of nucleobase metabolism (HP:0010932)2.89604237
64Spontaneous abortion (HP:0005268)2.88750445
65Myocardial infarction (HP:0001658)2.88073702
66Ketoacidosis (HP:0001993)2.85627995
67Vertebral clefting (HP:0008428)2.84368699
68Symphalangism affecting the phalanges of the hand (HP:0009773)2.83804133
69Abnormality of serum amino acid levels (HP:0003112)2.81900236
70Irregular epiphyses (HP:0010582)2.77265936
71Abnormal cartilage morphology (HP:0002763)2.76528916
72Delayed CNS myelination (HP:0002188)2.76318519
73Dicarboxylic aciduria (HP:0003215)2.73956008
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73956008
75Large earlobe (HP:0009748)2.72660086
76Abnormal vertebral ossification (HP:0100569)2.70661218
77Hepatocellular carcinoma (HP:0001402)2.69929791
78Abnormality of purine metabolism (HP:0004352)2.68386970
79Metabolic acidosis (HP:0001942)2.59694395
80Hypochromic microcytic anemia (HP:0004840)2.59002409
81Systemic lupus erythematosus (HP:0002725)2.56512220
82Skin nodule (HP:0200036)2.55384003
83Syncope (HP:0001279)2.55328592
84Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.54423892
85Vascular calcification (HP:0004934)2.53623801
86Hypoglycemic seizures (HP:0002173)2.50059187
87Abnormality of carpal bone ossification (HP:0006257)2.48684233
88Glomerulonephritis (HP:0000099)2.47983939
89Acanthocytosis (HP:0001927)2.47422037
90Abnormality of the 1st metacarpal (HP:0010009)2.45779689
91Lethargy (HP:0001254)2.45388530
92Spastic diplegia (HP:0001264)2.43445919
93Dehydration (HP:0001944)2.43082085
94Abnormal gallbladder physiology (HP:0012438)2.42092960
95Cholecystitis (HP:0001082)2.42092960
96Gout (HP:0001997)2.40015712
97Abnormal gallbladder morphology (HP:0012437)2.39365173
98Esophageal varix (HP:0002040)2.39193145
99Abnormal biliary tract morphology (HP:0012440)2.38248947
100Abnormal hair laboratory examination (HP:0003328)2.37610898
101Late onset (HP:0003584)2.33847752
102Cholelithiasis (HP:0001081)2.33297288
103Irritability (HP:0000737)2.30190578
104Abnormality of small intestinal villus morphology (HP:0011472)2.27297628
105Villous atrophy (HP:0011473)2.27297628
106Pancreatitis (HP:0001733)2.26344079
107Cardiovascular calcification (HP:0011915)2.26088711
108Increased density of long bones (HP:0006392)2.25509246
109Generalized aminoaciduria (HP:0002909)2.21816468
110Renal tubular acidosis (HP:0001947)2.18402837
111Petechiae (HP:0000967)2.16825844
112Congenital sensorineural hearing impairment (HP:0008527)2.16800463
113Aplasia/hypoplasia of the femur (HP:0005613)2.16440203
114Amyloidosis (HP:0011034)2.15249803
115Cerebral edema (HP:0002181)2.11801373
116Gingival bleeding (HP:0000225)2.11170317
117Mitral stenosis (HP:0001718)2.09741481
118Neonatal onset (HP:0003623)2.09589995
119Menorrhagia (HP:0000132)2.08241494
120Sensorimotor neuropathy (HP:0007141)2.07683137
121Chronic bronchitis (HP:0004469)2.06006752
122Hemorrhage of the eye (HP:0011885)2.04529017
123Abnormal foot bone ossification (HP:0010675)2.04285953
124Hoarse voice (HP:0001609)2.03575013
125Short middle phalanx of finger (HP:0005819)2.03043396
126Vomiting (HP:0002013)2.02045312
127Hyperactive renin-angiotensin system (HP:0000841)12.1415113
128Metabolic alkalosis (HP:0200114)10.6077159
129Hyperparathyroidism (HP:0000843)1.99719031
130Alkalosis (HP:0001948)1.99291327
131Hyperinsulinemic hypoglycemia (HP:0000825)1.98724714
132Abnormality of the gallbladder (HP:0005264)1.98268862
133Palpitations (HP:0001962)1.95592327
134Brushfield spots (HP:0001088)1.95043334
135Hydroxyprolinuria (HP:0003080)1.94645468
136Abnormality of proline metabolism (HP:0010907)1.94645468
137Thrombophlebitis (HP:0004418)1.94155963
138Poikilocytosis (HP:0004447)1.93716287
139Abnormal tarsal ossification (HP:0008369)1.93418558
140Bundle branch block (HP:0011710)1.93231540
141Rickets (HP:0002748)1.91863155
142Abnormal hand bone ossification (HP:0010660)1.90038702
143Renal cortical cysts (HP:0000803)1.89996468
144Enlarged kidneys (HP:0000105)1.88435255
145Abnormal ossification of hand bones (HP:0005921)1.87128196
146Glycosuria (HP:0003076)1.86787419
147Abnormality of urine glucose concentration (HP:0011016)1.86787419
148Cone-rod dystrophy (HP:0000548)1.86317085
149Hip contracture (HP:0003273)1.85652568
150Opisthotonus (HP:0002179)1.84850550
151Abnormality of transition element cation homeostasis (HP:0011030)1.84187136
152Symptomatic seizures (HP:0011145)1.83918678
153Short phalanx of the thumb (HP:0009660)1.83076031
154Abnormality of iron homeostasis (HP:0011031)1.82665831
155Hyperglycemia (HP:0003074)1.82456952
156Abnormal enzyme/coenzyme activity (HP:0012379)1.82407622
157Recurrent gram-negative bacterial infections (HP:0005420)1.76732552
158Increased purine levels (HP:0004368)1.76038078
159Biliary tract neoplasm (HP:0100574)1.75531423
160Amelogenesis imperfecta (HP:0000705)1.75394916
161Curly hair (HP:0002212)1.75240435
162Thin bony cortex (HP:0002753)1.74344070
163Renal salt wasting (HP:0000127)1.70335319
164Abnormality of the vitamin B12 metabolism (HP:0004341)1.69296835
165Severe short stature (HP:0003510)1.68518142
166Chronic diarrhea (HP:0002028)1.66872409
167Cerebral hemorrhage (HP:0001342)1.66341583
168Abnormality of the acetabulum (HP:0003170)1.64087864
169Stillbirth (HP:0003826)1.63018521
170Hip dysplasia (HP:0001385)1.60527587
171Hypotension (HP:0002615)1.59761249
172Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58715770
173Cupped ribs (HP:0000887)1.55675179
174Abnormality of the phalanges of the hallux (HP:0010057)1.55605949
175Abnormality of vitamin B metabolism (HP:0004340)1.54760823
176Protuberant abdomen (HP:0001538)1.53824449
177Eczematoid dermatitis (HP:0000976)1.53080792
178Neoplasm of the rectum (HP:0100743)1.49495704
179Bone pain (HP:0002653)1.47063635
180Ankle clonus (HP:0011448)1.42888828
181Axonal loss (HP:0003447)1.42284290
182Growth hormone excess (HP:0000845)1.41728617
183Abnormality of vitamin metabolism (HP:0100508)1.39937271
184Focal segmental glomerulosclerosis (HP:0000097)1.39815080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK39.22004091
2EPHA25.73908101
3BCKDK5.41822458
4ACVR1B5.38919408
5LMTK25.38471812
6MST1R4.18785179
7FGFR43.32473746
8ERN13.26014560
9SIK13.11118416
10EPHB22.41743694
11PIK3CA2.41142007
12PKN21.92296143
13PIK3CG1.88854199
14INSRR1.84985040
15WNK41.75524259
16KSR21.69544605
17MAP3K121.65659019
18STK241.64454592
19MET1.62241367
20TRIB31.58921991
21MAP2K21.58887813
22TESK21.57643250
23RIPK11.57283655
24TESK11.54977641
25ERBB41.49539439
26MAP3K21.49240004
27STK391.48590686
28PTK61.47846603
29FLT31.36314908
30MAPK111.28408371
31FRK1.21885979
32MAP2K41.18735887
33RIPK41.16664612
34GRK61.12390470
35ABL21.09422500
36KDR1.08479280
37MAP2K11.08396747
38TYK21.07491658
39MYLK1.07132995
40LATS11.02359319
41MAP3K141.00235434
42CAMK2D0.96778730
43DAPK20.94737545
44PTK20.91437641
45OXSR10.88161874
46PRKAA20.84889193
47JAK20.84866966
48ICK0.84146592
49FGFR20.83222817
50MST40.81451753
51MAP3K70.78754657
52TBK10.77623162
53TGFBR20.75116808
54DDR20.74658502
55ERBB20.71583600
56PAK40.70795904
57PRKCZ0.68837492
58NEK90.68296118
59PRPF4B0.66511759
60MAP2K30.66202509
61MAP3K10.66114569
62MAP3K30.63542760
63MAP3K100.63295265
64EPHB10.59096905
65MAP3K130.57941978
66TAOK10.57702064
67TIE10.57088395
68MAPK40.55126864
69PDPK10.53699978
70JAK10.53026269
71PRKACG0.52897519
72MAP3K110.52860843
73CSK0.52747075
74MAPK120.52334106
75RET0.51051615
76PRKCI0.50619726
77MATK0.49801688
78MAPK150.48859291
79CAMK2G0.48038573
80NME10.44986583
81SMG10.44306140
82PRKAA10.43308855
83CDK60.42246769
84GSK3A0.40841236
85MAP2K60.40815382
86CSNK1A10.40742825
87TNIK0.39828210
88RPS6KA20.39220280
89ARAF0.38989768
90DYRK1B0.38970453
91EPHA30.37171364
92MAP3K80.36214424
93MAPKAPK20.35248428
94STK38L0.34683002
95SRC0.34357515
96PRKCQ0.33902264
97CDK40.33856394
98FER0.33748132
99MTOR0.33625103
100NME20.33258272
101TAOK20.32793408
102PDK10.32677511
103PHKG20.32242472
104PHKG10.32242472
105IGF1R0.32060413
106CDC42BPA0.31956978
107DMPK0.30195084
108PDK20.29804510
109PINK10.29488824
110PRKG20.29459698
111CDK190.28883375
112LATS20.27677671
113PDK30.27423090
114PDK40.27423090
115CAMK1D0.27422621
116PTK2B0.26898699
117WNK10.26594681
118PDGFRA0.26149962
119IKBKE0.24520349
120PRKCA0.23074156
121SGK4940.21232932
122SGK2230.21232932
123EPHA40.19987570
124ITK0.19675199
125MAPK70.19621498
126FGFR10.19071714
127GRK10.18834390
128LYN0.18726863
129DAPK30.18566046
130BMX0.18071147
131NEK10.17338783
132ZAP700.17261092
133PAK20.17190547
134EGFR0.16657873
135MAPKAPK30.16639393
136PIM20.16384092
137YES10.16348632
138SGK30.16244256
139CSNK1G10.16187308
140RPS6KC10.15154194
141RPS6KL10.15154194
142ROCK10.14751655
143EEF2K0.10974420
144CDK90.10220578
145FGFR30.09209449
146FYN0.09142372
147RPS6KA60.08593301
148PRKCD0.07844582
149STK380.07596875
150PRKCB0.06342480
151LRRK20.06119722
152MAP4K10.05726926
153RPS6KB10.05455862
154NEK60.05319943
155ILK0.04821504

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26702212
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47010294
3Nitrogen metabolism_Homo sapiens_hsa009103.43605792
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.06690684
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06296653
6Arginine biosynthesis_Homo sapiens_hsa002202.84381278
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70296722
8Complement and coagulation cascades_Homo sapiens_hsa046102.63093236
9Tryptophan metabolism_Homo sapiens_hsa003802.62928400
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62029566
11Fatty acid degradation_Homo sapiens_hsa000712.46781964
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44902571
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40485876
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28114916
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17176827
16Butanoate metabolism_Homo sapiens_hsa006502.12652440
17Pancreatic secretion_Homo sapiens_hsa049722.06088090
18Chemical carcinogenesis_Homo sapiens_hsa052042.01484843
19Propanoate metabolism_Homo sapiens_hsa006402.00720849
20Steroid hormone biosynthesis_Homo sapiens_hsa001402.00632979
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00572128
22Peroxisome_Homo sapiens_hsa041461.96029912
23Histidine metabolism_Homo sapiens_hsa003401.92939734
24PPAR signaling pathway_Homo sapiens_hsa033201.92294733
25Sulfur metabolism_Homo sapiens_hsa009201.85094969
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.84346499
27Fatty acid metabolism_Homo sapiens_hsa012121.83625353
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77958408
29Retinol metabolism_Homo sapiens_hsa008301.71062191
30beta-Alanine metabolism_Homo sapiens_hsa004101.67405697
31Caffeine metabolism_Homo sapiens_hsa002321.66871025
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66851949
33Staphylococcus aureus infection_Homo sapiens_hsa051501.65723297
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59932903
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57526992
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55035594
37* Bile secretion_Homo sapiens_hsa049761.53118034
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44035421
39Selenocompound metabolism_Homo sapiens_hsa004501.43189878
40Pyruvate metabolism_Homo sapiens_hsa006201.42644887
41Phenylalanine metabolism_Homo sapiens_hsa003601.41077285
42Fat digestion and absorption_Homo sapiens_hsa049751.40890232
43Steroid biosynthesis_Homo sapiens_hsa001001.39823496
44Starch and sucrose metabolism_Homo sapiens_hsa005001.31302483
45Fatty acid elongation_Homo sapiens_hsa000621.30853719
46Tyrosine metabolism_Homo sapiens_hsa003501.29698218
47Folate biosynthesis_Homo sapiens_hsa007901.23429628
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.20882443
49Carbon metabolism_Homo sapiens_hsa012001.19189451
50ABC transporters_Homo sapiens_hsa020101.15422886
51Biosynthesis of amino acids_Homo sapiens_hsa012301.13975921
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.13501521
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.12550821
54Arginine and proline metabolism_Homo sapiens_hsa003300.97532431
55Sulfur relay system_Homo sapiens_hsa041220.96269471
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96086907
57Vitamin digestion and absorption_Homo sapiens_hsa049770.94817302
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92534294
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89555958
60Glycerolipid metabolism_Homo sapiens_hsa005610.84820705
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84580733
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83892240
63Glutathione metabolism_Homo sapiens_hsa004800.80209888
64Tight junction_Homo sapiens_hsa045300.79628816
65Vitamin B6 metabolism_Homo sapiens_hsa007500.79167859
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78556104
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76790051
68Pentose phosphate pathway_Homo sapiens_hsa000300.76585457
69Lysine degradation_Homo sapiens_hsa003100.70338511
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.67951700
71One carbon pool by folate_Homo sapiens_hsa006700.64452741
72Fatty acid biosynthesis_Homo sapiens_hsa000610.52371113
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49602019
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48770068
75Metabolic pathways_Homo sapiens_hsa011000.47594081
76Renin secretion_Homo sapiens_hsa049240.46631601
77Galactose metabolism_Homo sapiens_hsa000520.44028137
78Fructose and mannose metabolism_Homo sapiens_hsa000510.39905299
79Prion diseases_Homo sapiens_hsa050200.33827220
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32634278
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26179078
82Linoleic acid metabolism_Homo sapiens_hsa005910.23484095
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.21912649
84Sphingolipid metabolism_Homo sapiens_hsa006000.21823383
85Collecting duct acid secretion_Homo sapiens_hsa049660.20310853
86Gastric acid secretion_Homo sapiens_hsa049710.18367434
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.18073840
88Thyroid cancer_Homo sapiens_hsa052160.18042361
89Insulin resistance_Homo sapiens_hsa049310.17329828
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15791812
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.15302743
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14774733
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13507418
94Mineral absorption_Homo sapiens_hsa049780.13429310
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10357684
96Choline metabolism in cancer_Homo sapiens_hsa052310.09628859
97Ether lipid metabolism_Homo sapiens_hsa005650.07480105
98Salmonella infection_Homo sapiens_hsa051320.06917195
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04389481
100Inositol phosphate metabolism_Homo sapiens_hsa005620.03526988
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03314605
102Endocytosis_Homo sapiens_hsa041440.02151223
103Glucagon signaling pathway_Homo sapiens_hsa049220.00975792
104GnRH signaling pathway_Homo sapiens_hsa049120.00517723
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1826315
106Other glycan degradation_Homo sapiens_hsa00511-0.1769248
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1556657
108African trypanosomiasis_Homo sapiens_hsa05143-0.1371421
109Protein digestion and absorption_Homo sapiens_hsa04974-0.1343342
110Hepatitis C_Homo sapiens_hsa05160-0.1315821
111Regulation of autophagy_Homo sapiens_hsa04140-0.1270942
112Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1239462
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1223426
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1206846
115Amoebiasis_Homo sapiens_hsa05146-0.1099583
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1039500
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0999857
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0988874
119Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0887929
120Shigellosis_Homo sapiens_hsa05131-0.0715837
121Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0695128
122Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0682044
123Renin-angiotensin system_Homo sapiens_hsa04614-0.0674753
124Insulin signaling pathway_Homo sapiens_hsa04910-0.0669911
125Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0620727
126Pertussis_Homo sapiens_hsa05133-0.0561552
127Influenza A_Homo sapiens_hsa05164-0.0544518
128Allograft rejection_Homo sapiens_hsa05330-0.0534974
129Taste transduction_Homo sapiens_hsa04742-0.0476439
130Cardiac muscle contraction_Homo sapiens_hsa04260-0.0423845
131Vibrio cholerae infection_Homo sapiens_hsa05110-0.0198789
132Alzheimers disease_Homo sapiens_hsa05010-0.0186804
133AMPK signaling pathway_Homo sapiens_hsa04152-0.0126498

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