AQP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.52884031
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52884031
3L-phenylalanine metabolic process (GO:0006558)7.18184815
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18184815
5aromatic amino acid family catabolic process (GO:0009074)6.84750043
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27330384
7indole-containing compound catabolic process (GO:0042436)6.24387248
8indolalkylamine catabolic process (GO:0046218)6.24387248
9tryptophan catabolic process (GO:0006569)6.24387248
10kynurenine metabolic process (GO:0070189)6.09233119
11bile acid biosynthetic process (GO:0006699)5.99098298
12positive regulation by symbiont of host defense response (GO:0052509)5.91552773
13modulation by symbiont of host defense response (GO:0052031)5.91552773
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.91552773
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.91552773
16positive regulation by organism of defense response of other organism involved in symbiotic interact5.91552773
17modulation by symbiont of host immune response (GO:0052553)5.91552773
18tryptophan metabolic process (GO:0006568)5.88362555
19urea cycle (GO:0000050)5.73685780
20urea metabolic process (GO:0019627)5.73685780
21glyoxylate metabolic process (GO:0046487)5.71454111
22alpha-linolenic acid metabolic process (GO:0036109)5.61072461
23negative regulation of fibrinolysis (GO:0051918)5.59253529
24high-density lipoprotein particle remodeling (GO:0034375)5.54817207
25complement activation, alternative pathway (GO:0006957)5.48883202
26detection of molecule of bacterial origin (GO:0032490)5.47249925
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47126583
28negative regulation of cell killing (GO:0031342)5.47126583
29cysteine metabolic process (GO:0006534)5.45486174
30regulation of protein activation cascade (GO:2000257)5.41476620
31regulation of fibrinolysis (GO:0051917)5.38786647
32sulfur amino acid catabolic process (GO:0000098)5.37807295
33protein carboxylation (GO:0018214)5.37147982
34peptidyl-glutamic acid carboxylation (GO:0017187)5.37147982
35response to peptidoglycan (GO:0032494)5.35430824
36positive regulation of gamma-delta T cell activation (GO:0046645)5.28596369
37nitrogen cycle metabolic process (GO:0071941)5.27242041
38serine family amino acid catabolic process (GO:0009071)5.25405743
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20577670
40macrophage activation involved in immune response (GO:0002281)5.18753856
41bile acid metabolic process (GO:0008206)5.11527424
42regulation of complement activation (GO:0030449)5.07300125
43negative regulation of interleukin-12 production (GO:0032695)5.05167767
44aromatic amino acid family metabolic process (GO:0009072)5.01186993
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93365903
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.90899693
47detection of other organism (GO:0098543)4.89737204
48regulation of cholesterol esterification (GO:0010872)4.86672579
49neutrophil activation involved in immune response (GO:0002283)4.86495984
50homocysteine metabolic process (GO:0050667)4.84508064
51regulation of triglyceride catabolic process (GO:0010896)4.81024784
52reverse cholesterol transport (GO:0043691)4.80636995
53tyrosine metabolic process (GO:0006570)4.78397353
54protein-lipid complex remodeling (GO:0034368)4.74836900
55macromolecular complex remodeling (GO:0034367)4.74836900
56plasma lipoprotein particle remodeling (GO:0034369)4.74836900
57amino-acid betaine metabolic process (GO:0006577)4.71166439
58alpha-amino acid catabolic process (GO:1901606)4.66673652
59detection of external biotic stimulus (GO:0098581)4.65977733
60glycine metabolic process (GO:0006544)4.60314651
61lysine metabolic process (GO:0006553)4.59778028
62lysine catabolic process (GO:0006554)4.59778028
63regulation of interferon-beta biosynthetic process (GO:0045357)4.58697243
64triglyceride homeostasis (GO:0070328)4.57221587
65acylglycerol homeostasis (GO:0055090)4.57221587
66phospholipid efflux (GO:0033700)4.54828258
67negative regulation of sterol transport (GO:0032372)4.54677573
68negative regulation of cholesterol transport (GO:0032375)4.54677573
69indolalkylamine metabolic process (GO:0006586)4.42701337
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41702306
71imidazole-containing compound metabolic process (GO:0052803)4.41131993
72cellular extravasation (GO:0045123)4.40845978
73detection of bacterium (GO:0016045)4.36980668
74cellular ketone body metabolic process (GO:0046950)4.35409772
75coenzyme catabolic process (GO:0009109)4.35328029
76amine catabolic process (GO:0009310)4.35324966
77cellular biogenic amine catabolic process (GO:0042402)4.35324966
78plasma lipoprotein particle clearance (GO:0034381)4.33373985
79serine family amino acid metabolic process (GO:0009069)4.30260648
80cellular amino acid catabolic process (GO:0009063)4.27648367
81cellular glucuronidation (GO:0052695)4.23181768
82antigen processing and presentation of endogenous antigen (GO:0019883)4.19277771
83cholesterol efflux (GO:0033344)4.18280629
84* bile acid and bile salt transport (GO:0015721)4.16331047
85glutamate metabolic process (GO:0006536)4.15189820
86detection of biotic stimulus (GO:0009595)4.15006324
87serine family amino acid biosynthetic process (GO:0009070)4.13881137
88benzene-containing compound metabolic process (GO:0042537)4.12734604
89ethanol oxidation (GO:0006069)4.10434327
90neutrophil activation (GO:0042119)4.09299303
91regulation of B cell receptor signaling pathway (GO:0050855)4.08291008
92fibrinolysis (GO:0042730)4.04919354
93microglial cell activation (GO:0001774)4.04485850
94arginine metabolic process (GO:0006525)4.03675112
95low-density lipoprotein particle remodeling (GO:0034374)4.02727800
96leukocyte aggregation (GO:0070486)4.02487387
97blood coagulation, intrinsic pathway (GO:0007597)4.01609855
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.00007243
99response to host immune response (GO:0052572)4.00007243
100cellular modified amino acid catabolic process (GO:0042219)3.97574613
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97224692
102plasma lipoprotein particle assembly (GO:0034377)3.96363733
103macrophage activation (GO:0042116)3.95144159
104aldehyde catabolic process (GO:0046185)3.93402648
105leukocyte migration involved in inflammatory response (GO:0002523)3.93221232
106dicarboxylic acid biosynthetic process (GO:0043650)3.91822866
107neutrophil mediated immunity (GO:0002446)3.90503711
108drug catabolic process (GO:0042737)3.89598411
109granulocyte activation (GO:0036230)3.87249502
110regulation of gamma-delta T cell activation (GO:0046643)3.86883647
111lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86767846
112respiratory burst (GO:0045730)3.85122935
113cofactor catabolic process (GO:0051187)3.85000969
114complement activation, classical pathway (GO:0006958)3.84420214
115complement activation (GO:0006956)3.81920705
116negative regulation of lymphocyte mediated immunity (GO:0002707)3.81907483
117protein activation cascade (GO:0072376)3.80661777
118production of molecular mediator involved in inflammatory response (GO:0002532)3.79547283
119positive regulation of lipoprotein lipase activity (GO:0051006)3.77971220
120positive regulation of triglyceride lipase activity (GO:0061365)3.77971220
121ketone body metabolic process (GO:1902224)3.76048594
122carboxylic acid catabolic process (GO:0046395)3.74693473
123organic acid catabolic process (GO:0016054)3.74693473
124regulation of bile acid biosynthetic process (GO:0070857)3.74386115
125cholesterol homeostasis (GO:0042632)3.73027322
126glucuronate metabolic process (GO:0019585)3.72629528
127uronic acid metabolic process (GO:0006063)3.72629528
128very-low-density lipoprotein particle assembly (GO:0034379)3.72570417
129immunoglobulin mediated immune response (GO:0016064)3.72268050
130cytolysis (GO:0019835)3.70559449
131phospholipid homeostasis (GO:0055091)3.70004046
132positive regulation of lipid catabolic process (GO:0050996)3.69702252
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68810346
134negative regulation of lipase activity (GO:0060192)3.67947231
135sterol homeostasis (GO:0055092)3.66662543
136response to host (GO:0075136)3.64506429
137response to host defenses (GO:0052200)3.64506429
138response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.64506429
139NAD biosynthetic process (GO:0009435)3.63737924
140pyridine nucleotide biosynthetic process (GO:0019363)3.62446915
141nicotinamide nucleotide biosynthetic process (GO:0019359)3.62446915
142acetyl-CoA metabolic process (GO:0006084)3.61919165
143positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.61913170
144plasma lipoprotein particle organization (GO:0071827)3.60504903
145type I interferon signaling pathway (GO:0060337)3.59581928
146cellular response to type I interferon (GO:0071357)3.59581928
147germinal center formation (GO:0002467)3.59035648
148regulation of cholesterol homeostasis (GO:2000188)3.58290623
149short-chain fatty acid metabolic process (GO:0046459)3.57215612
150response to type I interferon (GO:0034340)3.55877218
151myeloid cell activation involved in immune response (GO:0002275)3.52726643
152response to interleukin-15 (GO:0070672)3.47120660
153positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.37265856
154regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.36926120
155defense response to protozoan (GO:0042832)3.35318925
156regulation of mast cell degranulation (GO:0043304)3.34570142
157negative regulation of leukocyte mediated immunity (GO:0002704)3.33869815
158positive regulation of interferon-alpha production (GO:0032727)3.33051396
159regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32877853
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.31646624
161myeloid leukocyte mediated immunity (GO:0002444)3.31305656
162regulation of interferon-alpha production (GO:0032647)3.30960981
163negative regulation of T cell mediated immunity (GO:0002710)3.29293153
164T-helper 1 type immune response (GO:0042088)3.27519584
165regulation of T-helper 2 cell differentiation (GO:0045628)3.27086312
166response to muramyl dipeptide (GO:0032495)3.25096130
167positive regulation of toll-like receptor signaling pathway (GO:0034123)3.23924250
168positive regulation of cellular amide metabolic process (GO:0034250)3.20171299
169cellular response to interleukin-15 (GO:0071350)3.12965143
170regulation of gamma-delta T cell differentiation (GO:0045586)3.12682066
171interferon-gamma-mediated signaling pathway (GO:0060333)3.11924613
172negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11388763
173negative regulation of cytokine production involved in immune response (GO:0002719)3.10308240
174positive regulation of mast cell activation (GO:0033005)3.08298191
175regulation of mast cell activation involved in immune response (GO:0033006)3.07657928
176regulation of tolerance induction (GO:0002643)3.05234711
177regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04392865
178response to protozoan (GO:0001562)3.00544250
179regulation of mast cell activation (GO:0033003)2.98875215
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96718060
181neutrophil chemotaxis (GO:0030593)2.96378255
182regulation of leukocyte degranulation (GO:0043300)2.91435771
183regulation of T cell tolerance induction (GO:0002664)2.91155463
184B cell mediated immunity (GO:0019724)2.90864019
185dendritic cell chemotaxis (GO:0002407)2.89836409
186negative regulation of interleukin-6 production (GO:0032715)2.89463634
187myeloid leukocyte activation (GO:0002274)2.89098589
188neutrophil migration (GO:1990266)2.88523499
189positive regulation of NF-kappaB import into nucleus (GO:0042346)2.86619035
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.86114111
191negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85300631
192regulation of toll-like receptor signaling pathway (GO:0034121)2.84981118
193positive regulation of type 2 immune response (GO:0002830)2.84355934
194dendritic cell migration (GO:0036336)2.83646940
195positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82529969
196regulation of interleukin-8 biosynthetic process (GO:0045414)2.82325420
197positive regulation of interferon-beta production (GO:0032728)2.79952614
198leukocyte degranulation (GO:0043299)2.79090441
199negative regulation of innate immune response (GO:0045824)2.77996594
200negative regulation of T-helper cell differentiation (GO:0045623)2.77066893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.37479204
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20907156
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.14534474
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.43254679
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28052670
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.27628258
7BP1_19119308_ChIP-ChIP_Hs578T_Human5.15559500
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80557192
9IRF8_21731497_ChIP-ChIP_J774_Mouse4.72334813
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.19038533
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83665176
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67179251
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.58627678
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52022506
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50082466
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47964493
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98474011
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95053686
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79182529
20SPI1_23547873_ChIP-Seq_NB4_Human2.54079596
21RUNX_20019798_ChIP-Seq_JUKART_Human2.49342572
22SPI1_23127762_ChIP-Seq_K562_Human2.47253380
23* VDR_24763502_ChIP-Seq_THP-1_Human2.30413507
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23744331
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23118819
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.18775342
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.14870156
28VDR_21846776_ChIP-Seq_THP-1_Human2.08420193
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04251128
30VDR_24787735_ChIP-Seq_THP-1_Human2.01982138
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01044493
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00311380
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9804636
34MAF_26560356_Chip-Seq_TH1_Human1.99211591
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.96637050
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94770662
37* MYB_26560356_Chip-Seq_TH2_Human1.94701492
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94686590
39SCL_19346495_ChIP-Seq_HPC-7_Human1.92000288
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90170466
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82208899
42MYB_26560356_Chip-Seq_TH1_Human1.68336388
43UTX_26944678_Chip-Seq_JUKART_Human1.67297887
44GATA1_22025678_ChIP-Seq_K562_Human1.65987267
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63393793
46TCF7_22412390_ChIP-Seq_EML_Mouse1.62148148
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61096307
48HTT_18923047_ChIP-ChIP_STHdh_Human1.60922922
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60537074
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54739745
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54724840
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54586937
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49485119
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.48562424
55GATA3_27048872_Chip-Seq_THYMUS_Human1.48260009
56PU_27001747_Chip-Seq_BMDM_Mouse1.46200567
57* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41828634
58CLOCK_20551151_ChIP-Seq_293T_Human1.41112178
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.38328178
60* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38178710
61MYC_22102868_ChIP-Seq_BL_Human1.35595934
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35321535
63MAF_26560356_Chip-Seq_TH2_Human1.33446485
64GATA3_26560356_Chip-Seq_TH2_Human1.33146591
65KDM2B_26808549_Chip-Seq_DND41_Human1.32408996
66* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32167320
67RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27547865
68* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26999038
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.26951613
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25132806
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25115570
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24832939
73* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23690062
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20991008
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19930941
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18958370
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18018359
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.16680223
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14737774
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14508687
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13476251
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10619587
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10422244
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07458648
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.05269153
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03754487
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02977778
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02164651
89KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01291533
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00305060
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99716735
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95898683
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94782975
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91796949
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.90363334
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90317430
97* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90094534
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87297404
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86446232
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85204206
101GATA4_25053715_ChIP-Seq_YYC3_Human0.82900576
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82312437
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81687395
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81532651
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80817887
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.80619363
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80299266
108BCL6_27268052_Chip-Seq_Bcells_Human0.79584875
109ZNF263_19887448_ChIP-Seq_K562_Human0.78855649
110* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76535308
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73572943
112* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71560399
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.71314903
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71202466
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70919908
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69885608
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67820098
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66262933
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65722606
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65121119
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64907124
122CEBPB_22108803_ChIP-Seq_LS180_Human0.62592196
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61088629
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60956161
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59243385
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.57070896
127AR_20517297_ChIP-Seq_VCAP_Human0.56670064
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.55548794
129P53_21459846_ChIP-Seq_SAOS-2_Human0.53186005
130* STAT1_17558387_ChIP-Seq_HELA_Human0.52793317
131* GATA1_19941827_ChIP-Seq_MEL_Mouse0.52184269
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.51227612
133MYC_19915707_ChIP-ChIP_AK7_Human0.50868674
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50322875
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50203517
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.49605591
137EGR1_19032775_ChIP-ChIP_M12_Human0.49550840
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49410718
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.48105088
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.48105088
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47542126
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46168548
143CBP_21632823_ChIP-Seq_H3396_Human0.46019978
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45538403
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45213864
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44831919
147TAF2_19829295_ChIP-Seq_ESCs_Human0.44335597
148LXR_22292898_ChIP-Seq_THP-1_Human0.43567428
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43464826
150GATA1_19941826_ChIP-Seq_K562_Human0.43365800
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.42099740
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.40334001
153BCOR_27268052_Chip-Seq_Bcells_Human0.40168202
154* GATA2_19941826_ChIP-Seq_K562_Human0.39630934
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39442420
156GATA6_25053715_ChIP-Seq_YYC3_Human0.38529199
157NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.38357026
158IRF1_19129219_ChIP-ChIP_H3396_Human0.38101306
159ESR1_21235772_ChIP-Seq_MCF-7_Human0.37689788
160* ERG_20517297_ChIP-Seq_VCAP_Human0.37323612
161SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.37180898
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36821541
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.36724607
164* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.36712135
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36566852
166LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35980579
167* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.35917217
168BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.35756700
169SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35279197
170NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.35162156
171PPAR_26484153_Chip-Seq_NCI-H1993_Human0.34916767
172PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.34015881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27537552
2MP0005360_urolithiasis7.37972568
3MP0005085_abnormal_gallbladder_physiolo6.43746761
4MP0005365_abnormal_bile_salt6.16984511
5MP0008875_abnormal_xenobiotic_pharmacok5.15645400
6MP0003303_peritoneal_inflammation4.69961705
7MP0003806_abnormal_nucleotide_metabolis4.21088563
8MP0003252_abnormal_bile_duct3.87920294
9MP0010329_abnormal_lipoprotein_level3.54221871
10MP0001835_abnormal_antigen_presentation3.42294624
11MP0009840_abnormal_foam_cell3.41354498
12MP0002419_abnormal_innate_immunity3.13322254
13MP0005083_abnormal_biliary_tract2.95589173
14MP0003195_calcinosis2.77441941
15* MP0005025_abnormal_response_to2.76819782
16MP0005000_abnormal_immune_tolerance2.76783600
17MP0005332_abnormal_amino_acid2.72900417
18MP0002148_abnormal_hypersensitivity_rea2.64582740
19MP0005671_abnormal_response_to2.64415397
20MP0001790_abnormal_immune_system2.61198401
21MP0005387_immune_system_phenotype2.61198401
22MP0001800_abnormal_humoral_immune2.60239954
23MP0001666_abnormal_nutrient_absorption2.53504647
24MP0002723_abnormal_immune_serum2.44779604
25MP0000685_abnormal_immune_system2.43037281
26MP0003191_abnormal_cellular_cholesterol2.39883380
27MP0003300_gastrointestinal_ulcer2.36734087
28MP0002452_abnormal_antigen_presenting2.35899096
29MP0001533_abnormal_skeleton_physiology2.23158561
30MP0002420_abnormal_adaptive_immunity2.22171368
31MP0001819_abnormal_immune_cell2.20862417
32MP0000609_abnormal_liver_physiology2.20204862
33MP0004019_abnormal_vitamin_homeostasis2.14836279
34* MP0002118_abnormal_lipid_homeostasis2.05315578
35MP0002138_abnormal_hepatobiliary_system1.97073089
36MP0003868_abnormal_feces_composition1.91410187
37MP0008260_abnormal_autophagy1.90919464
38MP0009278_abnormal_bone_marrow1.89794076
39MP0002405_respiratory_system_inflammati1.87858369
40MP0005319_abnormal_enzyme/_coenzyme1.87130439
41MP0001764_abnormal_homeostasis1.78807012
42MP0010155_abnormal_intestine_physiology1.72750679
43MP0003172_abnormal_lysosome_physiology1.72183298
44MP0004510_myositis1.71360789
45MP0009697_abnormal_copulation1.61931686
46MP0005451_abnormal_body_composition1.61344301
47MP0000716_abnormal_immune_system1.61283317
48MP0002277_abnormal_respiratory_mucosa1.58342039
49MP0003828_pulmonary_edema1.57513268
50MP0005584_abnormal_enzyme/coenzyme_acti1.55253706
51MP0002398_abnormal_bone_marrow1.52909565
52MP0005397_hematopoietic_system_phenotyp1.44487523
53MP0001545_abnormal_hematopoietic_system1.44487523
54MP0003011_delayed_dark_adaptation1.44046690
55MP0000858_altered_metastatic_potential1.42174946
56MP0003763_abnormal_thymus_physiology1.40840958
57MP0003186_abnormal_redox_activity1.37657687
58MP0009333_abnormal_splenocyte_physiolog1.36884773
59MP0005164_abnormal_response_to1.36280934
60MP0000465_gastrointestinal_hemorrhage1.34438198
61MP0002998_abnormal_bone_remodeling1.28330931
62MP0002722_abnormal_immune_system1.27096232
63MP0000689_abnormal_spleen_morphology1.26840410
64MP0008004_abnormal_stomach_pH1.26145943
65MP0002429_abnormal_blood_cell1.23115532
66MP0009643_abnormal_urine_homeostasis1.22906553
67MP0000598_abnormal_liver_morphology1.22289637
68MP0000343_altered_response_to1.20916255
69MP0005310_abnormal_salivary_gland1.20419685
70MP0005647_abnormal_sex_gland1.17621417
71MP0009764_decreased_sensitivity_to1.17340415
72MP0003448_altered_tumor_morphology1.15211378
73MP0003866_abnormal_defecation1.13320376
74MP0002332_abnormal_exercise_endurance1.13304790
75MP0003183_abnormal_peptide_metabolism1.09472736
76MP0009763_increased_sensitivity_to1.07805701
77MP0005167_abnormal_blood-brain_barrier1.06493863
78MP0000604_amyloidosis1.05159891
79MP0001851_eye_inflammation1.03907056
80MP0003705_abnormal_hypodermis_morpholog1.01775377
81* MP0003656_abnormal_erythrocyte_physiolo1.00969477
82MP0008469_abnormal_protein_level0.99262588
83MP0002254_reproductive_system_inflammat0.99147162
84MP0005636_abnormal_mineral_homeostasis0.96046147
85MP0000703_abnormal_thymus_morphology0.94317166
86MP0010368_abnormal_lymphatic_system0.88921700
87* MP0009642_abnormal_blood_homeostasis0.87347260
88MP0005408_hypopigmentation0.86730204
89MP0006036_abnormal_mitochondrial_physio0.86191847
90MP0005390_skeleton_phenotype0.85456910
91MP0009765_abnormal_xenobiotic_induced0.83601246
92MP0003221_abnormal_cardiomyocyte_apopto0.82366825
93MP0005670_abnormal_white_adipose0.81612576
94MP0005376_homeostasis/metabolism_phenot0.80729535
95MP0001663_abnormal_digestive_system0.77493870
96MP0005084_abnormal_gallbladder_morpholo0.75550224
97MP0003045_fibrosis0.74023218
98MP0002876_abnormal_thyroid_physiology0.72979553
99MP0002396_abnormal_hematopoietic_system0.71832884
100MP0005464_abnormal_platelet_physiology0.70960380
101MP0005220_abnormal_exocrine_pancreas0.70338514
102MP0001661_extended_life_span0.70091233
103MP0002971_abnormal_brown_adipose0.69635316
104* MP0002078_abnormal_glucose_homeostasis0.69586662
105MP0005334_abnormal_fat_pad0.68734618
106MP0003718_maternal_effect0.68210162
107MP0000569_abnormal_digit_pigmentation0.68029411
108MP0006054_spinal_hemorrhage0.66925563
109MP0003453_abnormal_keratinocyte_physiol0.66423787
110MP0004130_abnormal_muscle_cell0.66417841
111MP0002006_tumorigenesis0.65518083
112MP0003724_increased_susceptibility_to0.65425246
113MP0005535_abnormal_body_temperature0.65292073
114MP0002166_altered_tumor_susceptibility0.64047886
115MP0003690_abnormal_glial_cell0.63737428
116MP0005266_abnormal_metabolism0.63056460
117MP0004808_abnormal_hematopoietic_stem0.61642477
118MP0006035_abnormal_mitochondrial_morpho0.61173972
119MP0003091_abnormal_cell_migration0.60934174
120MP0003436_decreased_susceptibility_to0.60585362
121MP0000920_abnormal_myelination0.59997963
122MP0001756_abnormal_urination0.59354501
123MP0003329_amyloid_beta_deposits0.56264513
124MP0000639_abnormal_adrenal_gland0.55377548
125MP0005395_other_phenotype0.54934080
126MP0009053_abnormal_anal_canal0.53674460
127MP0005448_abnormal_energy_balance0.50870828
128MP0004381_abnormal_hair_follicle0.48834688
129MP0001853_heart_inflammation0.48681340
130MP0003638_abnormal_response/metabolism_0.48634947
131MP0008873_increased_physiological_sensi0.48110245
132MP0004782_abnormal_surfactant_physiolog0.47599703
133MP0002136_abnormal_kidney_physiology0.47151440
134MP0002928_abnormal_bile_duct0.43138221
135MP0008874_decreased_physiological_sensi0.43111196
136MP0006082_CNS_inflammation0.41527813
137MP0003075_altered_response_to0.41424456
138MP0002132_abnormal_respiratory_system0.41169938
139MP0005166_decreased_susceptibility_to0.39779511
140MP0001845_abnormal_inflammatory_respons0.38676784
141MP0008872_abnormal_physiological_respon0.38145415
142MP0003953_abnormal_hormone_level0.37558832
143MP0002796_impaired_skin_barrier0.36239602
144MP0009115_abnormal_fat_cell0.35956663
145MP0009672_abnormal_birth_weight0.34636331
146MP0002822_catalepsy0.34432915
147MP0000579_abnormal_nail_morphology0.34119737
148MP0005058_abnormal_lysosome_morphology0.33334745
149MP0005666_abnormal_adipose_tissue0.33225383
150MP0000249_abnormal_blood_vessel0.33037128
151MP0001243_abnormal_dermal_layer0.32331765
152MP0005248_abnormal_Harderian_gland0.31956905
153MP0009785_altered_susceptibility_to0.30587015
154MP0002970_abnormal_white_adipose0.30472043
155MP0004883_abnormal_blood_vessel0.29957756
156MP0001881_abnormal_mammary_gland0.29673452
157MP0000230_abnormal_systemic_arterial0.28590426
158MP0002837_dystrophic_cardiac_calcinosis0.28076258
159MP0004947_skin_inflammation0.26559428
160MP0002168_other_aberrant_phenotype0.26486972
161MP0005075_abnormal_melanosome_morpholog0.26034311

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33641414
2Deep venous thrombosis (HP:0002625)7.33115848
3Intrahepatic cholestasis (HP:0001406)7.28689436
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65126095
5Prolonged partial thromboplastin time (HP:0003645)6.61679104
6Eczematoid dermatitis (HP:0000976)6.47535664
7Hypobetalipoproteinemia (HP:0003563)6.38330490
8Orchitis (HP:0100796)6.33809640
9Xanthomatosis (HP:0000991)6.21700511
10Retrobulbar optic neuritis (HP:0100654)6.15008629
11Optic neuritis (HP:0100653)6.15008629
12Myositis (HP:0100614)6.12393986
13Recurrent bacterial skin infections (HP:0005406)5.93357428
14Recurrent abscess formation (HP:0002722)5.88408756
15Hyperlipoproteinemia (HP:0010980)5.64063820
16Abnormality of macrophages (HP:0004311)5.46190501
17Complement deficiency (HP:0004431)5.43750791
18Stomatitis (HP:0010280)5.05819212
19Joint hemorrhage (HP:0005261)4.82418824
20Hypolipoproteinemia (HP:0010981)4.76768486
21Hyperammonemia (HP:0001987)4.61508281
22Hyperglycinemia (HP:0002154)4.56270882
23Keratoconjunctivitis sicca (HP:0001097)4.47780719
24Epidermoid cyst (HP:0200040)4.46303951
25Abnormality of the common coagulation pathway (HP:0010990)4.44416447
26Elevated erythrocyte sedimentation rate (HP:0003565)4.40440132
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38074962
28Abnormality of methionine metabolism (HP:0010901)4.32522197
29Gastrointestinal infarctions (HP:0005244)4.29806504
30Abnormality of sulfur amino acid metabolism (HP:0004339)4.26130215
31Hypoalphalipoproteinemia (HP:0003233)4.15922065
32Mediastinal lymphadenopathy (HP:0100721)4.14798377
33Ketosis (HP:0001946)4.14626688
34Keratoconjunctivitis (HP:0001096)4.12271349
35Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11510677
36Fat malabsorption (HP:0002630)4.10435251
37Hyperglycinuria (HP:0003108)4.02412681
38Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01245384
39Abnormality of complement system (HP:0005339)3.99340723
40Abnormality of glycine metabolism (HP:0010895)3.98034294
41Abnormality of serine family amino acid metabolism (HP:0010894)3.98034294
42Abnormality of pyrimidine metabolism (HP:0004353)3.94694761
43Abnormality of the intrinsic pathway (HP:0010989)3.78294915
44Chronic obstructive pulmonary disease (HP:0006510)3.76374144
45Obstructive lung disease (HP:0006536)3.76374144
46Hypoglycemic coma (HP:0001325)3.71355867
47Conjugated hyperbilirubinemia (HP:0002908)3.70760707
48Recurrent skin infections (HP:0001581)3.70623661
49Recurrent fungal infections (HP:0002841)3.70426797
50Hypercholesterolemia (HP:0003124)3.63944214
51Meningitis (HP:0001287)3.62426137
52Encephalitis (HP:0002383)3.55537484
53Vasculitis (HP:0002633)3.54913729
54Gingivitis (HP:0000230)3.51329186
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41775275
56Hyperbilirubinemia (HP:0002904)3.37633438
57Abnormality of fatty-acid metabolism (HP:0004359)3.37602938
58Urticaria (HP:0001025)3.33566248
59Spontaneous hematomas (HP:0007420)3.31820093
60Peritonitis (HP:0002586)3.23398058
61Arterial thrombosis (HP:0004420)3.23352790
62Gangrene (HP:0100758)3.21964773
63Hemoptysis (HP:0002105)3.21128786
64Abnormality of serum amino acid levels (HP:0003112)3.19747669
65Steatorrhea (HP:0002570)3.14639531
66Spontaneous abortion (HP:0005268)3.14246253
67Anorexia (HP:0002039)3.13075889
68Episodic fever (HP:0001954)3.13042341
69Pulmonary infiltrates (HP:0002113)3.11336477
70Abnormal delayed hypersensitivity skin test (HP:0002963)3.10461604
71Abnormality of nucleobase metabolism (HP:0010932)3.10268432
72Increased IgE level (HP:0003212)3.08360815
73T lymphocytopenia (HP:0005403)3.07783741
74Delayed CNS myelination (HP:0002188)3.04959220
75Myocardial infarction (HP:0001658)2.98946362
76Abnormality of T cell number (HP:0011839)2.96098886
77Hepatocellular carcinoma (HP:0001402)2.94568854
78Abnormality of glycolipid metabolism (HP:0010969)2.93981001
79Abnormality of liposaccharide metabolism (HP:0010968)2.93981001
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.93981001
81Hypochromic microcytic anemia (HP:0004840)2.91801484
82Recurrent cutaneous fungal infections (HP:0011370)2.90143688
83Chronic mucocutaneous candidiasis (HP:0002728)2.90143688
84Chest pain (HP:0100749)2.88857337
85Systemic lupus erythematosus (HP:0002725)2.84987217
86Ketoacidosis (HP:0001993)2.80397873
87Metabolic acidosis (HP:0001942)2.73327493
88Leukocytosis (HP:0001974)2.72130625
89Acanthocytosis (HP:0001927)2.70703310
90Cellulitis (HP:0100658)2.69685582
91Skin nodule (HP:0200036)2.68599886
92Abnormality of purine metabolism (HP:0004352)2.68055268
93Lethargy (HP:0001254)2.63283390
94Hypochromic anemia (HP:0001931)2.63198058
95Increased IgM level (HP:0003496)2.63179803
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61839491
97Dicarboxylic aciduria (HP:0003215)2.61839491
98Recurrent gram-negative bacterial infections (HP:0005420)2.60327546
99Prolonged bleeding time (HP:0003010)2.60301380
100Vascular calcification (HP:0004934)2.54759153
101Abnormality of the pleura (HP:0002103)2.51504738
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50277395
103Glomerulonephritis (HP:0000099)2.49812655
104Epistaxis (HP:0000421)2.48914471
105Gout (HP:0001997)2.48389295
106Spastic diplegia (HP:0001264)2.46280089
107Gingival bleeding (HP:0000225)2.41069301
108Abnormal gallbladder morphology (HP:0012437)2.40865418
109Loss of speech (HP:0002371)2.37949741
110Recurrent viral infections (HP:0004429)2.37210504
111Cholelithiasis (HP:0001081)2.35579139
112Irritability (HP:0000737)2.35289747
113Cerebral edema (HP:0002181)2.34114372
114Mitral stenosis (HP:0001718)2.31824527
115Abnormality of the endocardium (HP:0004306)2.31543800
116Abnormality of the peritoneum (HP:0002585)2.31308317
117Cholecystitis (HP:0001082)2.31062195
118Abnormal gallbladder physiology (HP:0012438)2.31062195
119Hypoglycemic seizures (HP:0002173)2.29294612
120Increased cerebral lipofuscin (HP:0011813)2.28936222
121Menorrhagia (HP:0000132)2.28806413
122Neonatal onset (HP:0003623)2.27031153
123Increased serum ferritin (HP:0003281)2.25611666
124Amyloidosis (HP:0011034)2.24305166
125Cardiovascular calcification (HP:0011915)2.23396189
126Brushfield spots (HP:0001088)2.23025689
127Osteomyelitis (HP:0002754)2.22422383
128Acne (HP:0001061)2.22398572
129Glomerulopathy (HP:0100820)2.21927323
130Esophageal varix (HP:0002040)2.20916462
131Sepsis (HP:0100806)2.19564008
132Purpura (HP:0000979)2.19492054
133Abnormality of T cells (HP:0002843)2.19465368
134Poikilocytosis (HP:0004447)2.18987455
135Keratitis (HP:0000491)2.18225148
136Inflammation of the large intestine (HP:0002037)2.17764666
137Malnutrition (HP:0004395)2.17034095
138Autoimmune thrombocytopenia (HP:0001973)2.16962005
139Thrombophlebitis (HP:0004418)2.15701398
140Vertigo (HP:0002321)2.15693956
141Hypergammaglobulinemia (HP:0010702)2.14442634
142Disinhibition (HP:0000734)2.14262721
143Pancreatitis (HP:0001733)2.12710999
144Petechiae (HP:0000967)2.11769924
145Abnormality of the pericardium (HP:0001697)2.11513016
146Sensorimotor neuropathy (HP:0007141)2.10436006
147Granulocytopenia (HP:0001913)2.09156203
148Polyneuropathy (HP:0001271)2.08107201
149Joint swelling (HP:0001386)2.06668524
150Segmental peripheral demyelination/remyelination (HP:0003481)2.06240611
151Gastrointestinal inflammation (HP:0004386)2.05569121
152Generalized aminoaciduria (HP:0002909)2.03260212
153Opisthotonus (HP:0002179)2.02023425
154Vomiting (HP:0002013)2.00897548
155Abnormality of iron homeostasis (HP:0011031)2.00130762
156Microcytic anemia (HP:0001935)1.98382495
157Late onset (HP:0003584)1.98343936
158Hemorrhage of the eye (HP:0011885)1.96899712
159Abnormality of transition element cation homeostasis (HP:0011030)1.96174965
160Premature loss of primary teeth (HP:0006323)1.96112965
161Abnormality of the gallbladder (HP:0005264)1.95400677
162Enlarged kidneys (HP:0000105)1.94658302
163Pustule (HP:0200039)1.94377817
164Interstitial pulmonary disease (HP:0006530)1.93634447
165Slow saccadic eye movements (HP:0000514)1.93085506
166Hepatosplenomegaly (HP:0001433)1.91785122
167Eosinophilia (HP:0001880)1.91047483
168Renal cortical cysts (HP:0000803)1.88572371
169Elevated hepatic transaminases (HP:0002910)1.87421701
170Acute hepatic failure (HP:0006554)1.86390588
171Recurrent pneumonia (HP:0006532)1.85751717
172Abnormal cartilage morphology (HP:0002763)1.85447896
173Subacute progressive viral hepatitis (HP:0006572)1.83916727
174Autoimmune hemolytic anemia (HP:0001890)1.83592132
175Abnormal enzyme/coenzyme activity (HP:0012379)1.83420997
176Rickets (HP:0002748)1.82901503
177Hyperinsulinemic hypoglycemia (HP:0000825)1.80910651
178Skin ulcer (HP:0200042)1.79223312
179Arthralgia (HP:0002829)1.79156473
180Splenomegaly (HP:0001744)1.78891566
181Dysostosis multiplex (HP:0000943)1.78583027
182Nephritis (HP:0000123)1.75336946
183Reticulocytosis (HP:0001923)1.74781883
184Hydroxyprolinuria (HP:0003080)1.73431438
185Abnormality of proline metabolism (HP:0010907)1.73431438
186Hyperglycemia (HP:0003074)1.72257093
187Hypophosphatemic rickets (HP:0004912)1.71701635
188Hypertriglyceridemia (HP:0002155)1.71578843
189Pulmonary embolism (HP:0002204)1.71351796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17835834
2RIPK44.60603100
3FGFR44.54696533
4SIK14.24156369
5ERN14.18803385
6IRAK43.53850265
7TAOK33.37034138
8ERBB42.85730015
9INSRR2.73851052
10MAP2K42.21414072
11PKN22.12613313
12MST1R2.09265752
13TXK2.06623760
14MAPK112.04817444
15FLT32.04119802
16FGR2.02815027
17TYK22.00230172
18TAOK11.98244523
19FES1.92316542
20PRPF4B1.85662774
21PIK3CG1.76840524
22MATK1.71447287
23TRIB31.69864515
24TNK21.69200864
25LATS11.65542638
26ABL21.61213756
27HCK1.57149264
28PINK11.56333759
29NEK91.54171621
30IRAK21.50613125
31KDR1.44898671
32MAP3K11.42493704
33IRAK31.40909717
34SYK1.38268041
35BMPR21.37029375
36TBK11.35264984
37KSR21.34819913
38JAK21.33591124
39LYN1.31730665
40MAP2K31.29029027
41PTK61.26847032
42YES11.22740768
43SIK31.18151214
44DAPK21.17521734
45PRKAA21.16390238
46FRK1.15867400
47MAP3K141.09253789
48MAPK41.06672649
49GRK71.05088185
50TIE11.04847783
51JAK11.03533397
52MAP3K71.02224073
53GRK61.01339009
54ERBB20.99752637
55FGFR20.99368897
56LCK0.99350125
57MAP3K20.95954634
58MARK30.95893949
59MAP3K30.95661421
60STK38L0.92611619
61MAP3K110.89325397
62CDK60.86032540
63MARK20.83911801
64CSF1R0.78178076
65CDC42BPA0.77797939
66MAPK120.76643310
67EPHA30.74497753
68STK100.73968490
69MAP3K100.73375233
70ITK0.71922198
71EPHB10.71733162
72PRKACG0.71651039
73IKBKE0.71133930
74CAMK1D0.70000820
75MAP2K60.68878606
76PRKAA10.68119333
77CSK0.65942180
78CDK40.65389030
79TGFBR20.65105558
80TESK20.64854920
81MAP3K50.60113582
82MET0.59519165
83FYN0.59511405
84DYRK1B0.59328094
85PRKD20.59031069
86CAMK2G0.58245384
87MAPK150.58113370
88KIT0.57565073
89MAP4K10.57529278
90LRRK20.57035196
91SIK20.56303283
92PDK30.56291023
93PDK40.56291023
94GSK3A0.56042664
95GRK10.53706381
96KSR10.53267566
97CHUK0.52638361
98TAOK20.52471313
99RAF10.51728602
100TEC0.51613967
101CSNK1G10.51001201
102MOS0.50768201
103STK30.50252029
104SGK30.50121601
105MAP3K60.50019211
106FGFR30.49646530
107DYRK30.48563109
108MAPK70.48558313
109PDPK10.46717788
110STK110.46420909
111PIM10.44829882
112NLK0.43788475
113CDK190.43504189
114* PRKCZ0.43140549
115AKT30.42821923
116PTK2B0.41797761
117PRKCQ0.41568503
118HIPK20.41266410
119IGF1R0.40636832
120RIPK10.39037744
121WNK10.38267849
122STK160.38003386
123EIF2AK10.36618190
124RPS6KL10.35817045
125RPS6KC10.35817045
126MAP3K130.34394669
127PRKG20.34258673
128ACVR1B0.34201471
129SGK20.33907617
130MAPKAPK20.33006132
131ALK0.32740759
132PDK10.32622471
133PRKCG0.32325587
134EGFR0.32181575
135IKBKB0.31862622
136ZAP700.31681586
137PTK20.31215696
138BTK0.30507496
139PBK0.29973518
140BLK0.29792369
141IRAK10.29008809
142ABL10.27527591
143JAK30.27268569
144CSNK1G30.27259192
145MTOR0.26891565
146NUAK10.26079323
147RET0.24617153
148MAP2K10.24500603
149CSNK1G20.23994504

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55260682
2Nitrogen metabolism_Homo sapiens_hsa009103.53335185
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36242974
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33923493
5Leishmaniasis_Homo sapiens_hsa051403.18358036
6Osteoclast differentiation_Homo sapiens_hsa043803.16121177
7Arginine biosynthesis_Homo sapiens_hsa002203.02563582
8Complement and coagulation cascades_Homo sapiens_hsa046102.79782331
9Tryptophan metabolism_Homo sapiens_hsa003802.66369011
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64022135
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61323180
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60134121
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58479303
14Fatty acid degradation_Homo sapiens_hsa000712.47188662
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38493268
16Tuberculosis_Homo sapiens_hsa051522.34283475
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33834668
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28310628
19Malaria_Homo sapiens_hsa051442.22497916
20Graft-versus-host disease_Homo sapiens_hsa053322.15120656
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11563349
22Peroxisome_Homo sapiens_hsa041462.09598709
23Butanoate metabolism_Homo sapiens_hsa006502.06097729
24NF-kappa B signaling pathway_Homo sapiens_hsa040642.03811697
25Allograft rejection_Homo sapiens_hsa053302.02423584
26B cell receptor signaling pathway_Homo sapiens_hsa046621.98609663
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98585091
28Chemical carcinogenesis_Homo sapiens_hsa052041.95250351
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.94932489
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94868452
31Caffeine metabolism_Homo sapiens_hsa002321.94060089
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93280805
33Histidine metabolism_Homo sapiens_hsa003401.89047723
34Propanoate metabolism_Homo sapiens_hsa006401.88715907
35PPAR signaling pathway_Homo sapiens_hsa033201.86534738
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.85956402
37Staphylococcus aureus infection_Homo sapiens_hsa051501.85574447
38Measles_Homo sapiens_hsa051621.84503087
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84035030
40Fatty acid metabolism_Homo sapiens_hsa012121.76987608
41Retinol metabolism_Homo sapiens_hsa008301.74885621
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74133554
43beta-Alanine metabolism_Homo sapiens_hsa004101.71977127
44TNF signaling pathway_Homo sapiens_hsa046681.71663675
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71150460
46Autoimmune thyroid disease_Homo sapiens_hsa053201.70248189
47Influenza A_Homo sapiens_hsa051641.67229302
48Chemokine signaling pathway_Homo sapiens_hsa040621.64963676
49Selenocompound metabolism_Homo sapiens_hsa004501.63551754
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59722739
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55357720
52Toxoplasmosis_Homo sapiens_hsa051451.54655293
53Phenylalanine metabolism_Homo sapiens_hsa003601.53720481
54Type I diabetes mellitus_Homo sapiens_hsa049401.53667322
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50297466
56Hematopoietic cell lineage_Homo sapiens_hsa046401.49416775
57Acute myeloid leukemia_Homo sapiens_hsa052211.48847074
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47017311
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45852170
60Phagosome_Homo sapiens_hsa041451.41061297
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.40803595
62Tyrosine metabolism_Homo sapiens_hsa003501.40687549
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.39526151
64Rheumatoid arthritis_Homo sapiens_hsa053231.37318039
65* Bile secretion_Homo sapiens_hsa049761.34853038
66Folate biosynthesis_Homo sapiens_hsa007901.34342433
67Salmonella infection_Homo sapiens_hsa051321.32495257
68Pyruvate metabolism_Homo sapiens_hsa006201.32079961
69T cell receptor signaling pathway_Homo sapiens_hsa046601.31203579
70Fatty acid elongation_Homo sapiens_hsa000621.28655549
71Primary immunodeficiency_Homo sapiens_hsa053401.28538297
72Herpes simplex infection_Homo sapiens_hsa051681.26736983
73Sulfur metabolism_Homo sapiens_hsa009201.25644804
74Starch and sucrose metabolism_Homo sapiens_hsa005001.25487053
75ABC transporters_Homo sapiens_hsa020101.24439027
76Biosynthesis of amino acids_Homo sapiens_hsa012301.23000018
77Vitamin B6 metabolism_Homo sapiens_hsa007501.21542876
78Antigen processing and presentation_Homo sapiens_hsa046121.21189398
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20471789
80Hepatitis B_Homo sapiens_hsa051611.19157664
81Other glycan degradation_Homo sapiens_hsa005111.17009809
82Steroid biosynthesis_Homo sapiens_hsa001001.15911528
83Fat digestion and absorption_Homo sapiens_hsa049751.13296703
84Carbon metabolism_Homo sapiens_hsa012001.11737495
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11293165
86Viral myocarditis_Homo sapiens_hsa054161.08909202
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04316568
88Intestinal immune network for IgA production_Homo sapiens_hsa046721.02857183
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02598445
90Lysosome_Homo sapiens_hsa041421.02454258
91Sulfur relay system_Homo sapiens_hsa041221.00122576
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00101435
93Shigellosis_Homo sapiens_hsa051310.98171548
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.96724792
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96425117
96Asthma_Homo sapiens_hsa053100.96197174
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94950412
98Arginine and proline metabolism_Homo sapiens_hsa003300.94464162
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.94373907
100Vitamin digestion and absorption_Homo sapiens_hsa049770.93334123
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.92019106
102Non-small cell lung cancer_Homo sapiens_hsa052230.89816348
103Apoptosis_Homo sapiens_hsa042100.89666557
104Prolactin signaling pathway_Homo sapiens_hsa049170.89515045
105Amoebiasis_Homo sapiens_hsa051460.87747084
106Pancreatic cancer_Homo sapiens_hsa052120.84519087
107VEGF signaling pathway_Homo sapiens_hsa043700.81983625
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81966543
109One carbon pool by folate_Homo sapiens_hsa006700.81625133
110Platelet activation_Homo sapiens_hsa046110.80851011
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77380793
112Chronic myeloid leukemia_Homo sapiens_hsa052200.76232409
113Lysine degradation_Homo sapiens_hsa003100.75574749
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.72809403
115Pentose phosphate pathway_Homo sapiens_hsa000300.69448442
116Renal cell carcinoma_Homo sapiens_hsa052110.69363911
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68277965
118Glycerolipid metabolism_Homo sapiens_hsa005610.67716554
119Glutathione metabolism_Homo sapiens_hsa004800.66337024
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.63429957
121FoxO signaling pathway_Homo sapiens_hsa040680.61029935
122Dorso-ventral axis formation_Homo sapiens_hsa043200.60508455
123Notch signaling pathway_Homo sapiens_hsa043300.57136955
124Type II diabetes mellitus_Homo sapiens_hsa049300.56970880
125Endocytosis_Homo sapiens_hsa041440.54701141
126Fatty acid biosynthesis_Homo sapiens_hsa000610.54588170
127HIF-1 signaling pathway_Homo sapiens_hsa040660.52440399
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52280329
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50419027
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50339169
131Epstein-Barr virus infection_Homo sapiens_hsa051690.49694977
132Metabolic pathways_Homo sapiens_hsa011000.48577030
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.45289198
134Viral carcinogenesis_Homo sapiens_hsa052030.44696719
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41510365
136Endometrial cancer_Homo sapiens_hsa052130.40483633
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37813458
138GnRH signaling pathway_Homo sapiens_hsa049120.36665052
139Prion diseases_Homo sapiens_hsa050200.35014454
140mTOR signaling pathway_Homo sapiens_hsa041500.33667063
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33602160
142Choline metabolism in cancer_Homo sapiens_hsa052310.33376764
143MAPK signaling pathway_Homo sapiens_hsa040100.33268792
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30181186
145Linoleic acid metabolism_Homo sapiens_hsa005910.30000152
146Bladder cancer_Homo sapiens_hsa052190.29933426
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29380858
148Collecting duct acid secretion_Homo sapiens_hsa049660.28807793
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27025331
150ErbB signaling pathway_Homo sapiens_hsa040120.26586583
151Galactose metabolism_Homo sapiens_hsa000520.25941914
152Fructose and mannose metabolism_Homo sapiens_hsa000510.25902137
153Rap1 signaling pathway_Homo sapiens_hsa040150.25888608
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.22734722
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.22720277
156Insulin resistance_Homo sapiens_hsa049310.20779973
157Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16039238
158Glucagon signaling pathway_Homo sapiens_hsa049220.05927341
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01422774
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2424167
161Ether lipid metabolism_Homo sapiens_hsa00565-0.2353910
162Legionellosis_Homo sapiens_hsa05134-0.2346086
163Pertussis_Homo sapiens_hsa05133-0.2119570
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2004031
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1990875
166Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1968428
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1910046
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1838322
169Hepatitis C_Homo sapiens_hsa05160-0.1639965
170Pyrimidine metabolism_Homo sapiens_hsa00240-0.1587553
171Renin-angiotensin system_Homo sapiens_hsa04614-0.1558807
172African trypanosomiasis_Homo sapiens_hsa05143-0.1490072
173Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1410072
174Insulin signaling pathway_Homo sapiens_hsa04910-0.1329805
175Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1278481
176Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0856676
177Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0716424
178Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0647783
179Regulation of autophagy_Homo sapiens_hsa04140-0.0063450
180AMPK signaling pathway_Homo sapiens_hsa04152-0.0008323

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