AR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)7.65935417
2opsonization (GO:0008228)6.81552327
3iron ion import (GO:0097286)5.58549401
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.57892205
5carnitine shuttle (GO:0006853)5.52073726
6artery development (GO:0060840)5.31379962
7prostate gland epithelium morphogenesis (GO:0060740)4.94229501
8fatty acid transmembrane transport (GO:1902001)4.84375856
9epithelial cell maturation (GO:0002070)4.79789691
10positive regulation of macrophage cytokine production (GO:0060907)4.64891736
11regulation of receptor binding (GO:1900120)4.62944083
12insulin-like growth factor receptor signaling pathway (GO:0048009)4.22407996
13carnitine transmembrane transport (GO:1902603)4.18465988
14regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.10930387
15regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.01512778
16Golgi to endosome transport (GO:0006895)3.95765209
17intestinal epithelial cell development (GO:0060576)3.91514285
18carnitine transport (GO:0015879)3.87846248
19amino-acid betaine transport (GO:0015838)3.87846248
20quaternary ammonium group transport (GO:0015697)3.68179877
21positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.67647511
22import into cell (GO:0098657)3.60917452
23response to testosterone (GO:0033574)3.49895818
24epithelial cell differentiation involved in prostate gland development (GO:0060742)3.48308539
25epoxygenase P450 pathway (GO:0019373)3.48067817
26pharyngeal system development (GO:0060037)3.44097511
27omega-hydroxylase P450 pathway (GO:0097267)3.43230126
28negative regulation of glycogen biosynthetic process (GO:0045719)3.43093988
29positive regulation of steroid hormone secretion (GO:2000833)3.32445462
30lung epithelial cell differentiation (GO:0060487)3.30180214
31mitotic cell cycle arrest (GO:0071850)3.23162468
32lung cell differentiation (GO:0060479)3.22796116
33regulation of fatty acid beta-oxidation (GO:0031998)3.22143919
34regulation of protein polyubiquitination (GO:1902914)3.21720647
35L-serine metabolic process (GO:0006563)3.21244551
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.20660331
37valine metabolic process (GO:0006573)3.16794611
38coenzyme A metabolic process (GO:0015936)3.12463533
39exogenous drug catabolic process (GO:0042738)3.10394539
40vocalization behavior (GO:0071625)3.06686161
41regulation of plasminogen activation (GO:0010755)3.05875021
42fatty-acyl-CoA biosynthetic process (GO:0046949)3.05183885
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.04850900
44positive regulation of cellular amine metabolic process (GO:0033240)3.04840209
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00631609
46embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98718416
47coenzyme A biosynthetic process (GO:0015937)2.96045770
48regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.92596188
49drug catabolic process (GO:0042737)2.90060433
50presynaptic membrane assembly (GO:0097105)2.84660817
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82571030
52lung lobe morphogenesis (GO:0060463)2.81314402
53endothelial cell chemotaxis (GO:0035767)2.80784621
54thioester biosynthetic process (GO:0035384)2.80631724
55acyl-CoA biosynthetic process (GO:0071616)2.80631724
56anterior/posterior axis specification, embryo (GO:0008595)2.79005345
57gamma-aminobutyric acid signaling pathway (GO:0007214)2.78993403
58positive regulation of histone deacetylation (GO:0031065)2.78264312
59positive regulation of smoothened signaling pathway (GO:0045880)2.77576035
60basement membrane organization (GO:0071711)2.76546491
61positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.74339163
62neuronal action potential propagation (GO:0019227)2.71583471
63endoplasmic reticulum organization (GO:0007029)2.70602108
64regulation of glucose import in response to insulin stimulus (GO:2001273)2.69909923
65negative regulation of cell size (GO:0045792)2.68215779
66purine nucleotide transport (GO:0015865)2.66790404
67peptidyl-tyrosine autophosphorylation (GO:0038083)2.66781608
68apical protein localization (GO:0045176)2.66628991
69auditory receptor cell differentiation (GO:0042491)2.66434181
70negative regulation of DNA repair (GO:0045738)2.66049914
71cytoskeletal anchoring at plasma membrane (GO:0007016)2.65730794
72negative regulation of fatty acid transport (GO:2000192)2.65660509
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64733755
74L-phenylalanine catabolic process (GO:0006559)2.64733755
75regulation of female receptivity (GO:0045924)2.64648412
76establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63279055
77regulation of ARF protein signal transduction (GO:0032012)2.63036421
78ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.62002723
79nucleoside bisphosphate biosynthetic process (GO:0033866)2.62002723
80purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.62002723
81negative regulation of potassium ion transmembrane transport (GO:1901380)2.61576659
82vascular endothelial growth factor signaling pathway (GO:0038084)2.60657231
83regulation of endothelial cell chemotaxis (GO:2001026)2.60269660
84sulfur amino acid catabolic process (GO:0000098)2.59684082
85piRNA metabolic process (GO:0034587)2.59241487
86regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.58861636
87glutamate secretion (GO:0014047)2.58517647
88intracellular lipid transport (GO:0032365)2.57811354
89cysteine metabolic process (GO:0006534)2.56303956
90regulation of macrophage cytokine production (GO:0010935)2.55925524
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55827715
92neurotransmitter catabolic process (GO:0042135)2.53531879
93neuron cell-cell adhesion (GO:0007158)2.53521180
94short-chain fatty acid metabolic process (GO:0046459)2.52927622
95oxidative demethylation (GO:0070989)2.52919231
96negative regulation of glycogen metabolic process (GO:0070874)2.52707584
97regulation of cholesterol biosynthetic process (GO:0045540)2.52383440
98ethanol oxidation (GO:0006069)2.50200416
99positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.49282124
100regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48518780
101complement activation, alternative pathway (GO:0006957)2.46701865
102positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46566585
103presynaptic membrane organization (GO:0097090)2.46534756
104protein localization to synapse (GO:0035418)2.45283631
105negative regulation of lipase activity (GO:0060192)2.45275857
106phenol-containing compound catabolic process (GO:0019336)2.44803402
107glutamate receptor signaling pathway (GO:0007215)2.44061193
108serine family amino acid biosynthetic process (GO:0009070)2.42314196
109response to phenylpropanoid (GO:0080184)2.40894937
110positive regulation of fatty acid oxidation (GO:0046321)2.40820402
111regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.40630728
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39971272
113L-phenylalanine metabolic process (GO:0006558)2.39971272
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.38295458
115regulation of glutamate receptor signaling pathway (GO:1900449)2.38110466
116membrane assembly (GO:0071709)2.37282489
117negative regulation of dendrite morphogenesis (GO:0050774)2.37086578
118female mating behavior (GO:0060180)2.37012691
119succinate metabolic process (GO:0006105)2.35513263
120branched-chain amino acid metabolic process (GO:0009081)2.33900657
121regulation of glutamate secretion (GO:0014048)2.33757829
122aromatic amino acid family catabolic process (GO:0009074)2.33068340
1232-oxoglutarate metabolic process (GO:0006103)2.31893189
124oxaloacetate metabolic process (GO:0006107)2.29506992
125drug transmembrane transport (GO:0006855)2.27940718
126neurotransmitter-gated ion channel clustering (GO:0072578)2.25877163
127mating behavior (GO:0007617)2.25496900
128synaptic vesicle docking involved in exocytosis (GO:0016081)2.25340929
129regulation of neuronal synaptic plasticity (GO:0048168)2.22048366
130neurotransmitter secretion (GO:0007269)2.20471702
131regulation of synaptic vesicle exocytosis (GO:2000300)2.20430048
132fatty acid oxidation (GO:0019395)2.20157462
133bile acid biosynthetic process (GO:0006699)2.20105292
134ethanol metabolic process (GO:0006067)2.19916969
135negative regulation of dendrite development (GO:2000171)2.19836293
136protein targeting to Golgi (GO:0000042)2.18415811
137regulation of excitatory postsynaptic membrane potential (GO:0060079)2.18005776
138desmosome organization (GO:0002934)2.17673818
139glutamate metabolic process (GO:0006536)2.17038395
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.16910285
141cellular ketone body metabolic process (GO:0046950)2.16310605
142branched-chain amino acid catabolic process (GO:0009083)2.15999006
143cellular modified amino acid catabolic process (GO:0042219)2.15512959
144behavioral response to cocaine (GO:0048148)2.15472490
145response to histamine (GO:0034776)2.15402225
146lipid oxidation (GO:0034440)2.14915886
147positive regulation of fatty acid beta-oxidation (GO:0032000)2.13959916
148regulation of long-term neuronal synaptic plasticity (GO:0048169)2.12152242
149regulation of clathrin-mediated endocytosis (GO:2000369)2.11267447
150fatty-acyl-CoA metabolic process (GO:0035337)2.10525478
151positive regulation of respiratory burst (GO:0060267)2.08628396
152fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.08240274
153regulation of postsynaptic membrane potential (GO:0060078)2.07852745
154indole-containing compound catabolic process (GO:0042436)2.07798153
155indolalkylamine catabolic process (GO:0046218)2.07798153
156tryptophan catabolic process (GO:0006569)2.07798153
157kynurenine metabolic process (GO:0070189)2.07478863
158acylglycerol catabolic process (GO:0046464)2.06886770
159neutral lipid catabolic process (GO:0046461)2.06886770
160synaptic vesicle exocytosis (GO:0016079)2.05111333
161high-density lipoprotein particle remodeling (GO:0034375)2.05011365
162benzene-containing compound metabolic process (GO:0042537)2.04492461
163tryptophan metabolic process (GO:0006568)2.04422323
164postsynaptic membrane organization (GO:0001941)2.04274406
165regulation of protein kinase A signaling (GO:0010738)2.03448944
166glyoxylate metabolic process (GO:0046487)2.02895444
167fatty acid catabolic process (GO:0009062)2.02825171
168suckling behavior (GO:0001967)2.02502297
169glucocorticoid metabolic process (GO:0008211)2.02075741
170triglyceride catabolic process (GO:0019433)2.01983758
171alpha-linolenic acid metabolic process (GO:0036109)2.01840347
172long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.00929879
173neuron-neuron synaptic transmission (GO:0007270)2.00237498
174calcium-mediated signaling using intracellular calcium source (GO:0035584)1.99997678
175very long-chain fatty acid metabolic process (GO:0000038)1.99379149
176amino-acid betaine metabolic process (GO:0006577)1.98924314
177fatty acid beta-oxidation (GO:0006635)1.98765698
178biotin metabolic process (GO:0006768)1.98740976
179proline transport (GO:0015824)1.97961023
180positive regulation of vesicle fusion (GO:0031340)1.97824130
181innervation (GO:0060384)1.97745739
182negative regulation of synaptic transmission, GABAergic (GO:0032229)1.97024349
183negative regulation of protein autophosphorylation (GO:0031953)1.95989829
184acetyl-CoA metabolic process (GO:0006084)1.95633193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21909140_ChIP-Seq_LNCAP_Human5.36375488
2CHD1_26751641_Chip-Seq_LNCaP_Human3.25067875
3FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.20360613
4GBX2_23144817_ChIP-Seq_PC3_Human3.11698290
5* FOXA1_25552417_ChIP-Seq_VCAP_Human3.11056430
6AR_21915096_ChIP-Seq_LNCaP-1F5_Human3.08869883
7EZH2_22144423_ChIP-Seq_EOC_Human3.05084502
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.75856238
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68093621
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47340929
11ZNF263_19887448_ChIP-Seq_K562_Human2.40407553
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32980044
13TAF15_26573619_Chip-Seq_HEK293_Human2.29517926
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23692596
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.23608398
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20467613
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19757773
18* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12357330
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12357330
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04797966
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02973898
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01127954
23RACK7_27058665_Chip-Seq_MCF-7_Human2.00700220
24* EED_16625203_ChIP-ChIP_MESCs_Mouse1.99913629
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96697073
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92392194
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89950846
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.82214421
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80820127
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79864035
31* PIAS1_25552417_ChIP-Seq_VCAP_Human1.79799954
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78013276
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77120262
34AR_21572438_ChIP-Seq_LNCaP_Human1.75983564
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75657153
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75657153
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75657153
38CLOCK_20551151_ChIP-Seq_293T_Human1.73875824
39CREB1_26743006_Chip-Seq_LNCaP_Human1.72907354
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70794079
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70731394
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68543489
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.65695815
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62983925
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62947236
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.60483577
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.59023933
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58076409
49P300_19829295_ChIP-Seq_ESCs_Human1.55140366
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54420133
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53741997
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52627465
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52571058
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.51974791
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51328437
56* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51200775
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.50191624
58BCAT_22108803_ChIP-Seq_LS180_Human1.49690792
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49145140
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47230465
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46024186
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.45841775
63AHR_22903824_ChIP-Seq_MCF-7_Human1.43741896
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43337966
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42931989
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.42654408
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42620737
68HTT_18923047_ChIP-ChIP_STHdh_Human1.41538335
69KDM5A_27292631_Chip-Seq_BREAST_Human1.41141825
70TP53_18474530_ChIP-ChIP_U2OS_Human1.40033880
71DROSHA_22980978_ChIP-Seq_HELA_Human1.39892939
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38749615
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38749615
74* EZH2_27294783_Chip-Seq_ESCs_Mouse1.38344932
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38064441
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.37999411
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.34499547
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34125093
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34095540
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32884037
81AR_25329375_ChIP-Seq_VCAP_Human1.32861349
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32786126
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32671593
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32182312
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.31488104
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31223522
87ELF5_23300383_ChIP-Seq_T47D_Human1.31121719
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.30381787
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29175968
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28536280
91GATA6_25053715_ChIP-Seq_YYC3_Human1.27749829
92VDR_22108803_ChIP-Seq_LS180_Human1.27182093
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26918871
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25599189
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25431866
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25318622
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25204752
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24907316
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22222835
100* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22147057
101ERG_20517297_ChIP-Seq_VCAP_Human1.21797443
102* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21753129
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.21553681
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21089471
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20676592
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19649496
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18204272
108RXR_22108803_ChIP-Seq_LS180_Human1.18201370
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17392371
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.17224104
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16372914
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14643285
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14540743
114TP53_16413492_ChIP-PET_HCT116_Human1.13570788
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13331749
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.12146673
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.11960536
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.11831176
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10760075
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.08725799
121REST_21632747_ChIP-Seq_MESCs_Mouse1.07798348
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.07724329
123ER_23166858_ChIP-Seq_MCF-7_Human1.07184692
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06797565
125ZNF274_21170338_ChIP-Seq_K562_Hela1.06784299
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.03759233
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.03759233
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03048372
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01748772
130STAT3_23295773_ChIP-Seq_U87_Human1.01029473
131GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00518349
132TCF4_22108803_ChIP-Seq_LS180_Human0.99763414
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99683886
134TCF7_22412390_ChIP-Seq_EML_Mouse0.99050925
135KDM2B_26808549_Chip-Seq_REH_Human0.98969175
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.98882088
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97155329
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97140909
139RUNX2_22187159_ChIP-Seq_PCA_Human0.96425001
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96102333
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95029327
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.94692073
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94404932
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.94271874
145HNF4A_19822575_ChIP-Seq_HepG2_Human0.93791563
146RARB_27405468_Chip-Seq_BRAIN_Mouse0.93670494
147FUS_26573619_Chip-Seq_HEK293_Human0.93434471
148GATA4_25053715_ChIP-Seq_YYC3_Human0.92841563
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92581963
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.92580644
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.92367038
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91706515
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91437404
154CBP_20019798_ChIP-Seq_JUKART_Human0.91437404
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90705209
156* TCF4_23295773_ChIP-Seq_U87_Human0.90509314
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90006444
158IGF1R_20145208_ChIP-Seq_DFB_Human0.89745915
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.89731314
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89602460
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88862646
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.88781316
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88066668
164CJUN_26792858_Chip-Seq_BT549_Human0.87288499
165SMC4_20622854_ChIP-Seq_HELA_Human0.85949657
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84989161
167DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81214316
168FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81163523
169* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80102462
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80064854
171KDM2B_26808549_Chip-Seq_K562_Human0.79362326
172NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77658721
173TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76930025
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.75871711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.39772660
2MP0002139_abnormal_hepatobiliary_system3.25198751
3MP0003283_abnormal_digestive_organ3.08308461
4MP0003705_abnormal_hypodermis_morpholog2.97729806
5MP0004233_abnormal_muscle_weight2.87382682
6MP0005645_abnormal_hypothalamus_physiol2.79440756
7MP0005275_abnormal_skin_tensile2.77256470
8MP0010386_abnormal_urinary_bladder2.72922343
9MP0005360_urolithiasis2.70172445
10MP0004859_abnormal_synaptic_plasticity2.67684636
11MP0008438_abnormal_cutaneous_collagen2.60604065
12MP0002234_abnormal_pharynx_morphology2.59872080
13MP0002876_abnormal_thyroid_physiology2.56714736
14MP0009780_abnormal_chondrocyte_physiolo2.56537859
15MP0004185_abnormal_adipocyte_glucose2.43815197
16MP0005310_abnormal_salivary_gland2.39660796
17MP0003195_calcinosis2.39326975
18MP0005367_renal/urinary_system_phenotyp2.33210684
19MP0000516_abnormal_urinary_system2.33210684
20* MP0002166_altered_tumor_susceptibility2.33142251
21MP0008875_abnormal_xenobiotic_pharmacok2.28343284
22MP0001501_abnormal_sleep_pattern2.27763574
23MP0001968_abnormal_touch/_nociception2.22287513
24MP0002837_dystrophic_cardiac_calcinosis2.20428036
25MP0003635_abnormal_synaptic_transmissio2.12467722
26MP0005451_abnormal_body_composition2.12242389
27MP0009745_abnormal_behavioral_response2.03200045
28MP0002736_abnormal_nociception_after1.94651733
29MP0005365_abnormal_bile_salt1.88815806
30MP0006276_abnormal_autonomic_nervous1.86921600
31MP0004270_analgesia1.83015046
32MP0000751_myopathy1.81650643
33MP0008961_abnormal_basal_metabolism1.80668745
34MP0005085_abnormal_gallbladder_physiolo1.78996101
35MP0009046_muscle_twitch1.78038274
36MP0010234_abnormal_vibrissa_follicle1.75803608
37MP0010329_abnormal_lipoprotein_level1.70501088
38MP0002063_abnormal_learning/memory/cond1.69876215
39MP0005503_abnormal_tendon_morphology1.68654021
40MP0002254_reproductive_system_inflammat1.66377919
41MP0003123_paternal_imprinting1.63561377
42MP0000013_abnormal_adipose_tissue1.63372725
43MP0004130_abnormal_muscle_cell1.62394215
44MP0002064_seizures1.61391119
45MP0001873_stomach_inflammation1.59081118
46MP0009053_abnormal_anal_canal1.58078810
47MP0005076_abnormal_cell_differentiation1.55571583
48MP0005220_abnormal_exocrine_pancreas1.53467844
49MP0002272_abnormal_nervous_system1.52861145
50* MP0000537_abnormal_urethra_morphology1.52082242
51MP0002572_abnormal_emotion/affect_behav1.52058817
52MP0000534_abnormal_ureter_morphology1.51458739
53MP0001661_extended_life_span1.50371759
54MP0005670_abnormal_white_adipose1.50098983
55MP0002796_impaired_skin_barrier1.47258279
56MP0005332_abnormal_amino_acid1.45950549
57MP0002735_abnormal_chemical_nociception1.44890037
58* MP0004145_abnormal_muscle_electrophysio1.41961319
59MP0000566_synostosis1.41652572
60MP0005535_abnormal_body_temperature1.39801726
61MP0001765_abnormal_ion_homeostasis1.38845381
62MP0005647_abnormal_sex_gland1.37653906
63* MP0002006_tumorigenesis1.35823545
64MP0000613_abnormal_salivary_gland1.34016783
65MP0003942_abnormal_urinary_system1.33867404
66MP0004272_abnormal_basement_membrane1.33529550
67MP0004019_abnormal_vitamin_homeostasis1.33290758
68MP0001984_abnormal_olfaction1.31807066
69MP0004264_abnormal_extraembryonic_tissu1.30584961
70MP0003868_abnormal_feces_composition1.30419705
71MP0003252_abnormal_bile_duct1.29678447
72MP0001764_abnormal_homeostasis1.29451030
73MP0002249_abnormal_larynx_morphology1.27758832
74MP0000733_abnormal_muscle_development1.27554057
75MP0001440_abnormal_grooming_behavior1.26303904
76MP0000427_abnormal_hair_cycle1.25124861
77MP0002822_catalepsy1.23054832
78MP0002734_abnormal_mechanical_nocicepti1.22079984
79* MP0003315_abnormal_perineum_morphology1.18672457
80MP0003941_abnormal_skin_development1.17834553
81MP0009379_abnormal_foot_pigmentation1.17743611
82MP0002067_abnormal_sensory_capabilities1.17615238
83MP0000750_abnormal_muscle_regeneration1.17255079
84MP0001486_abnormal_startle_reflex1.17197403
85MP0002108_abnormal_muscle_morphology1.17185895
86MP0002909_abnormal_adrenal_gland1.14682631
87MP0003329_amyloid_beta_deposits1.09102162
88MP0005646_abnormal_pituitary_gland1.08490139
89MP0002733_abnormal_thermal_nociception1.05708655
90MP0006138_congestive_heart_failure1.04922133
91MP0001177_atelectasis1.04783694
92MP0000230_abnormal_systemic_arterial1.04239171
93MP0002118_abnormal_lipid_homeostasis1.02635812
94MP0002653_abnormal_ependyma_morphology1.00382694
95MP0004087_abnormal_muscle_fiber1.00316856
96MP0004858_abnormal_nervous_system0.98909668
97MP0001970_abnormal_pain_threshold0.98381875
98MP0001188_hyperpigmentation0.95328595
99MP0008874_decreased_physiological_sensi0.94992759
100MP0005666_abnormal_adipose_tissue0.94857137
101MP0004924_abnormal_behavior0.94694621
102MP0005386_behavior/neurological_phenoty0.94694621
103MP0001756_abnormal_urination0.93729790
104MP0002060_abnormal_skin_morphology0.91194780
105MP0001348_abnormal_lacrimal_gland0.91166255
106MP0000604_amyloidosis0.89441884
107MP0001944_abnormal_pancreas_morphology0.89344723
108MP0002184_abnormal_innervation0.88311644
109MP0010630_abnormal_cardiac_muscle0.88174714
110MP0010368_abnormal_lymphatic_system0.86634340
111MP0002971_abnormal_brown_adipose0.84675345
112* MP0000538_abnormal_urinary_bladder0.84567845
113MP0004484_altered_response_of0.84551826
114MP0003879_abnormal_hair_cell0.83651759
115MP0005334_abnormal_fat_pad0.83340937
116* MP0005636_abnormal_mineral_homeostasis0.83183622
117MP0003045_fibrosis0.82960688
118* MP0002557_abnormal_social/conspecific_i0.82875847
119MP0005584_abnormal_enzyme/coenzyme_acti0.82826215
120MP0004084_abnormal_cardiac_muscle0.81874684
121MP0004147_increased_porphyrin_level0.81699663
122MP0001485_abnormal_pinna_reflex0.79362114
123MP0005187_abnormal_penis_morphology0.78494473
124MP0005375_adipose_tissue_phenotype0.78139634
125MP0002269_muscular_atrophy0.77675911
126MP0001502_abnormal_circadian_rhythm0.77313984
127MP0002088_abnormal_embryonic_growth/wei0.76480215
128MP0000759_abnormal_skeletal_muscle0.75920717
129MP0001299_abnormal_eye_distance/0.75743949
130MP0003633_abnormal_nervous_system0.75376423
131MP0010771_integument_phenotype0.75061644
132MP0003984_embryonic_growth_retardation0.75002391
133* MP0000627_abnormal_mammary_gland0.74435038
134MP0002168_other_aberrant_phenotype0.74247790
135MP0002896_abnormal_bone_mineralization0.74142570
136MP0002295_abnormal_pulmonary_circulatio0.74020155
137MP0001346_abnormal_lacrimal_gland0.73820447
138* MP0004036_abnormal_muscle_relaxation0.73530316
139MP0003638_abnormal_response/metabolism_0.72484225
140MP0000003_abnormal_adipose_tissue0.72037785
141MP0002069_abnormal_eating/drinking_beha0.71756825
142MP0002078_abnormal_glucose_homeostasis0.71659803
143MP0002160_abnormal_reproductive_system0.71099601
144MP0000467_abnormal_esophagus_morphology0.70623477
145MP0003011_delayed_dark_adaptation0.70075336
146MP0008872_abnormal_physiological_respon0.70010470
147MP0003959_abnormal_lean_body0.69726681
148MP0005369_muscle_phenotype0.69568258
149MP0009643_abnormal_urine_homeostasis0.69533757
150MP0005620_abnormal_muscle_contractility0.68218800
151MP0008569_lethality_at_weaning0.67298833
152MP0001666_abnormal_nutrient_absorption0.67291612
153MP0002090_abnormal_vision0.66731595
154MP0009250_abnormal_appendicular_skeleto0.66673150
155MP0009384_cardiac_valve_regurgitation0.66433374
156MP0005448_abnormal_energy_balance0.64480871
157MP0001881_abnormal_mammary_gland0.63039481
158MP0000266_abnormal_heart_morphology0.61302251
159MP0004085_abnormal_heartbeat0.60195607
160MP0005330_cardiomyopathy0.59865860
161MP0003953_abnormal_hormone_level0.58574176

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.32248972
2Sparse lateral eyebrow (HP:0005338)5.09385232
3Abnormality of the 1st metacarpal (HP:0010009)4.74989454
4Neonatal hypoglycemia (HP:0001998)4.61011578
5Short 1st metacarpal (HP:0010034)4.14105031
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.14105031
7Hyperventilation (HP:0002883)4.10280134
8Septate vagina (HP:0001153)3.87418615
9Broad face (HP:0000283)3.78930558
10Short phalanx of the thumb (HP:0009660)3.75551910
11Overgrowth (HP:0001548)3.75138481
12Oligomenorrhea (HP:0000876)3.65351374
13Abnormality of the parathyroid morphology (HP:0011766)3.62534500
14Flat acetabular roof (HP:0003180)3.60640139
15Abnormality of carpal bone ossification (HP:0006257)3.50039505
16Atonic seizures (HP:0010819)3.37169684
17Shallow orbits (HP:0000586)3.36171541
18Abnormality of the distal phalanx of the thumb (HP:0009617)3.31117495
19Abnormality of the proximal phalanges of the hand (HP:0009834)3.30995812
20Lip pit (HP:0100267)3.28421729
21Focal seizures (HP:0007359)3.24205744
22Abnormal tarsal ossification (HP:0008369)3.19555915
23Absence seizures (HP:0002121)3.17282924
24Obstructive sleep apnea (HP:0002870)3.10762868
25Abnormality of the phalanges of the hallux (HP:0010057)3.10140169
26Abnormal hand bone ossification (HP:0010660)3.08978632
27Myokymia (HP:0002411)3.05838415
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.04672223
29Germ cell neoplasia (HP:0100728)2.98132369
30Abnormality of the fingertips (HP:0001211)2.92377758
31Aplasia involving bones of the extremities (HP:0009825)2.87932297
32Aplasia involving bones of the upper limbs (HP:0009823)2.87932297
33Aplasia of the phalanges of the hand (HP:0009802)2.87932297
34Abnormal ossification of hand bones (HP:0005921)2.81999348
35Action tremor (HP:0002345)2.81199642
36Advanced eruption of teeth (HP:0006288)2.80681594
37Complement deficiency (HP:0004431)2.76816606
38Anal stenosis (HP:0002025)2.75609054
39Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.71068977
40Neoplasm of the adrenal cortex (HP:0100641)2.65077802
41Depressed nasal tip (HP:0000437)2.63892283
42Generalized tonic-clonic seizures (HP:0002069)2.61486910
43Cervical subluxation (HP:0003308)2.60235475
44Febrile seizures (HP:0002373)2.58221342
45Acanthosis nigricans (HP:0000956)2.57488312
46Hyperglycinuria (HP:0003108)2.55809280
47Dialeptic seizures (HP:0011146)2.53641147
48Ketosis (HP:0001946)2.53198542
49Deep venous thrombosis (HP:0002625)2.52694160
50Macroorchidism (HP:0000053)2.52199293
51Spontaneous abortion (HP:0005268)2.50432722
52Exercise-induced myalgia (HP:0003738)2.49447734
53Ketoacidosis (HP:0001993)2.46732579
54Hypophosphatemic rickets (HP:0004912)2.42748359
55Abnormal eating behavior (HP:0100738)2.35949134
56Fibular aplasia (HP:0002990)2.34534310
57Abnormal foot bone ossification (HP:0010675)2.33346254
58Abnormality of serine family amino acid metabolism (HP:0010894)2.32422454
59Abnormality of glycine metabolism (HP:0010895)2.32422454
60Laryngomalacia (HP:0001601)2.28146635
61Abnormality of the nasal septum (HP:0000419)2.27697845
62Aplasia of the musculature (HP:0100854)2.25512096
63Prolonged partial thromboplastin time (HP:0003645)2.25114960
64Hyperglycinemia (HP:0002154)2.24932430
65Myotonia (HP:0002486)2.24164229
6611 pairs of ribs (HP:0000878)2.22852777
67Neonatal death (HP:0003811)2.20220992
68Xanthomatosis (HP:0000991)2.17988300
69Short nail (HP:0001799)2.17836458
70Hypoplasia of the odontoid process (HP:0003311)2.16959949
71Short humerus (HP:0005792)2.16761346
72Scanning speech (HP:0002168)2.16372214
73Hyperkalemia (HP:0002153)2.15055608
74Increased variability in muscle fiber diameter (HP:0003557)2.14226364
75Glossoptosis (HP:0000162)2.13177444
76Hyperthyroidism (HP:0000836)2.11745573
77Polyphagia (HP:0002591)2.11543074
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10381961
79Infantile muscular hypotonia (HP:0008947)2.10274679
80Progressive cerebellar ataxia (HP:0002073)2.08694226
81Hyporeflexia of lower limbs (HP:0002600)2.08570333
82Dysmetric saccades (HP:0000641)2.05511224
83Amelogenesis imperfecta (HP:0000705)2.05161178
84Precocious puberty (HP:0000826)2.05115750
85Visual hallucinations (HP:0002367)2.01057189
86Epileptic encephalopathy (HP:0200134)2.00983346
87Excessive salivation (HP:0003781)2.00030145
88Drooling (HP:0002307)2.00030145
89Type 1 muscle fiber predominance (HP:0003803)1.99724816
90Cardiovascular calcification (HP:0011915)1.99364106
91Fair hair (HP:0002286)1.97318771
92Broad-based gait (HP:0002136)1.97014601
93Broad metatarsal (HP:0001783)1.96959507
94Abnormality of the Achilles tendon (HP:0005109)1.96826583
95Long eyelashes (HP:0000527)1.95358092
96Exotropia (HP:0000577)1.91338701
97Increased circulating renin level (HP:0000848)1.89276038
98Aortic aneurysm (HP:0004942)1.89272807
99Gout (HP:0001997)1.87477086
100Hypoventilation (HP:0002791)1.86433713
101Hypoalphalipoproteinemia (HP:0003233)1.85729641
102Increased connective tissue (HP:0009025)1.85315007
103Epidermoid cyst (HP:0200040)1.84456932
104Aplastic anemia (HP:0001915)1.84036871
105Choanal stenosis (HP:0000452)1.83474770
106Blue irides (HP:0000635)1.83366836
107Aplasia/hypoplasia of the humerus (HP:0006507)1.83100770
108Broad nasal tip (HP:0000455)1.82845014
109Vascular calcification (HP:0004934)1.82812464
110Dysdiadochokinesis (HP:0002075)1.82767145
111Abnormal social behavior (HP:0012433)1.81578802
112Impaired social interactions (HP:0000735)1.81578802
113Blue sclerae (HP:0000592)1.81213934
114Conjugated hyperbilirubinemia (HP:0002908)1.81114714
115Anxiety (HP:0000739)1.81060408
116Abnormality of purine metabolism (HP:0004352)1.80499641
117Status epilepticus (HP:0002133)1.79315909
118Narrow palate (HP:0000189)1.79150791
119Hypokalemic alkalosis (HP:0001949)1.78379223
120Popliteal pterygium (HP:0009756)1.77459381
121Hyperlipoproteinemia (HP:0010980)1.76202318
122Right ventricular cardiomyopathy (HP:0011663)1.76087833
123Intrahepatic cholestasis (HP:0001406)1.75313853
124Hypoplastic nipples (HP:0002557)1.74500747
125Narrow nasal bridge (HP:0000446)1.73224452
126Back pain (HP:0003418)1.73097719
127Hypomagnesemia (HP:0002917)1.72717244
128Cerebral inclusion bodies (HP:0100314)1.72353254
129Shawl scrotum (HP:0000049)1.71537115
130Achilles tendon contracture (HP:0001771)1.71290415
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70743828
132Delayed CNS myelination (HP:0002188)1.68930339
133Abnormality of the odontoid process (HP:0003310)1.68400764
134Facial diplegia (HP:0001349)1.68027457
135Abnormality of skeletal muscle fiber size (HP:0012084)1.67703814
136* Gonadotropin excess (HP:0000837)1.67396479
137Intention tremor (HP:0002080)1.66710116
138Ulnar claw (HP:0001178)1.66092374
139Bronchomalacia (HP:0002780)1.65762625
140Myocardial infarction (HP:0001658)1.65729988
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65706562
142Abnormal cartilage morphology (HP:0002763)1.65403189
143Hypothermia (HP:0002045)1.64305019
144Metabolic alkalosis (HP:0200114)1.63962695
145Impaired smooth pursuit (HP:0007772)1.62437590
146Hyperactive renin-angiotensin system (HP:0000841)1.62096978
147Amblyopia (HP:0000646)1.62070960
148Dysmetria (HP:0001310)1.62067093
149Long palpebral fissure (HP:0000637)1.61669206
150* Hyperpituitarism (HP:0010514)1.61260769
151Distal arthrogryposis (HP:0005684)1.59950871
152Vertebral clefting (HP:0008428)1.59940924
153Hyperuricemia (HP:0002149)1.59719573
154Increased purine levels (HP:0004368)1.59719573
155Abnormality of complement system (HP:0005339)1.59355692
156Impaired vibration sensation in the lower limbs (HP:0002166)1.59044839
157Polycystic kidney dysplasia (HP:0000113)1.58747866
158Hyperammonemia (HP:0001987)1.57713112
159Hypopigmentation of the fundus (HP:0007894)1.57638483
160Neoplasm of the adrenal gland (HP:0100631)1.57337134
161Short hallux (HP:0010109)1.57078451
162Generalized hypopigmentation of hair (HP:0011358)1.56991243
163Gaze-evoked nystagmus (HP:0000640)1.56090088
164Asymmetric septal hypertrophy (HP:0001670)1.55623574
165Rickets (HP:0002748)1.55602915
166Seborrheic dermatitis (HP:0001051)1.55506228
167Growth hormone excess (HP:0000845)1.55312774
168Spinal cord compression (HP:0002176)1.54799159
169Abnormality of the distal phalanges of the toes (HP:0010182)1.54723013
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.54149248
171Renal cortical cysts (HP:0000803)1.51654035
172Exercise-induced muscle cramps (HP:0003710)1.51530742
173Death in childhood (HP:0003819)1.51252122
174Abnormality of sulfur amino acid metabolism (HP:0004339)1.50789672
175Abnormality of the 2nd finger (HP:0004100)1.50348527
176Lymphangioma (HP:0100764)1.49959902
177Relative macrocephaly (HP:0004482)1.49503583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.00339621
2EEF2K4.15051496
3TAOK14.11913069
4TRIB33.80708002
5CASK3.74913338
6EPHA43.24961001
7PIM22.93903953
8OXSR12.92135111
9NTRK32.90343350
10PRKD22.86219936
11STK392.77755757
12AKT32.66631188
13MAP3K42.63814387
14MAP3K122.32951774
15MAP2K42.18460591
16FRK2.09375102
17RIPK41.94619792
18INSRR1.92963467
19MARK21.91761942
20MAP2K71.91162813
21MYLK1.88863703
22SMG11.87152103
23PKN21.80357266
24DAPK21.56487414
25NTRK11.56259962
26BCKDK1.54425903
27MTOR1.48538238
28ICK1.47027034
29PDK21.43959678
30CDK121.38235162
31MST1R1.37007751
32SIK11.34265370
33MINK11.33811672
34FGFR21.33667872
35BMPR21.31146834
36PRKCI1.26734874
37MAP3K21.26177998
38PIK3CA1.20376081
39PDK31.19618658
40PDK41.19618658
41PAK21.19505943
42SGK21.19290120
43MAP3K91.18515004
44LMTK21.17897159
45GRK51.17090259
46WNK31.16667155
47WNK41.16291403
48MST41.14731410
49PLK21.10821155
50CAMK1G1.10642313
51ARAF1.09526834
52RAF11.07544177
53LATS11.07296666
54MAPKAPK31.07036747
55MAP3K71.05853857
56PTK2B1.03081651
57PHKG11.02609876
58PHKG21.02609876
59STK381.01956327
60SGK2231.00669449
61SGK4941.00669449
62ERN10.98317133
63* FER0.95734497
64SGK30.94736332
65CAMK1D0.94279626
66PIK3CG0.93636246
67CAMK2A0.89045936
68TAF10.88088777
69PRKAA10.86364852
70EIF2AK10.85098074
71BRSK20.84635259
72IRAK20.84587533
73MUSK0.83869516
74PRKCG0.79749088
75* CDK50.79540831
76PRKCE0.78486407
77SCYL20.78345073
78EPHA20.77899551
79PDGFRA0.76765560
80DMPK0.76271869
81WNK10.75768301
82DAPK10.72367778
83LATS20.72044885
84CAMKK20.70918055
85RET0.69581706
86BCR0.66588403
87SGK10.64820379
88PINK10.64365178
89PAK30.63624167
90TTN0.62758307
91CAMK2G0.62464741
92MAPK120.62442797
93MAP2K10.62093167
94CAMK2B0.60545643
95ILK0.60524062
96MAPK130.58778800
97NEK60.58567834
98CDK190.58116665
99TNIK0.57857319
100FGFR30.57444215
101PDPK10.57223167
102CAMKK10.56868416
103PRKD10.56197361
104GRK70.55870253
105PDK10.55561112
106MAPKAPK50.55515309
107BRD40.55454546
108PRKCH0.55286746
109ADRBK10.54784725
110PRPF4B0.53965788
111GRK10.52825620
112JAK10.52282671
113BRAF0.51871114
114IRAK30.50977788
115KSR20.50903040
116CAMK10.50093356
117EPHB20.50063912
118PRKCZ0.49820515
119ROCK20.49702199
120TRPM70.49591920
121PRKCQ0.48829872
122MAP3K130.48511428
123OBSCN0.48504890
124RPS6KA20.48326771
125ADRBK20.48149571
126CDK90.46211231
127DYRK1B0.45885550
128NME10.45768916
129CAMK2D0.44042112
130GSK3A0.42166250
131ROCK10.41645778
132MAPK70.40160445
133PNCK0.38711455
134PRKAA20.38190046
135RPS6KB20.37989438
136JAK20.37437132
137PRKACA0.37090894
138NEK90.35922297
139MAPK100.35792689
140TESK10.35044457
141PTK20.35005684
142CHUK0.33298805
143PDGFRB0.33134016
144AKT20.33080995
145CSNK1E0.33079520
146GSK3B0.30129686
147TESK20.30056272
148STK110.27413888
149CAMK40.25106329
150* MAPK80.24974157
151RPS6KL10.24922284
152RPS6KC10.24922284
153RPS6KA60.19092639
154PRKDC0.18951674
155* AKT10.18259937
156RPS6KB10.17078054
157* MAPK140.16177347
158CSNK2A20.15950531
159STK38L0.15818466
160* CDK10.15544121

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.39832181
2Lysine degradation_Homo sapiens_hsa003102.33457268
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31820981
4Renin-angiotensin system_Homo sapiens_hsa046142.14415502
5Caffeine metabolism_Homo sapiens_hsa002322.09409469
6Propanoate metabolism_Homo sapiens_hsa006402.06479561
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.79617907
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74953962
9Fatty acid degradation_Homo sapiens_hsa000711.73472288
10Arginine and proline metabolism_Homo sapiens_hsa003301.69850394
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68909762
12Renin secretion_Homo sapiens_hsa049241.62389890
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58544959
14PPAR signaling pathway_Homo sapiens_hsa033201.56538175
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56111741
16Long-term potentiation_Homo sapiens_hsa047201.55158291
17Sulfur metabolism_Homo sapiens_hsa009201.53663063
18Butanoate metabolism_Homo sapiens_hsa006501.51772046
19Salivary secretion_Homo sapiens_hsa049701.51706503
20Fatty acid metabolism_Homo sapiens_hsa012121.50621586
21Amphetamine addiction_Homo sapiens_hsa050311.49098608
22Nitrogen metabolism_Homo sapiens_hsa009101.48829003
23Arginine biosynthesis_Homo sapiens_hsa002201.48510934
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45621455
25Fatty acid biosynthesis_Homo sapiens_hsa000611.44794650
26GABAergic synapse_Homo sapiens_hsa047271.40362205
27Steroid biosynthesis_Homo sapiens_hsa001001.40076178
28AMPK signaling pathway_Homo sapiens_hsa041521.34504969
29Circadian entrainment_Homo sapiens_hsa047131.31360125
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29075325
31Peroxisome_Homo sapiens_hsa041461.25944324
32Morphine addiction_Homo sapiens_hsa050321.25818162
33Synaptic vesicle cycle_Homo sapiens_hsa047211.25341830
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.25326858
35Glutamatergic synapse_Homo sapiens_hsa047241.22994021
36Collecting duct acid secretion_Homo sapiens_hsa049661.21811581
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21221965
38Olfactory transduction_Homo sapiens_hsa047401.20763478
39Taste transduction_Homo sapiens_hsa047421.19575110
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19337776
41beta-Alanine metabolism_Homo sapiens_hsa004101.17254820
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16771095
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16755082
44Pyruvate metabolism_Homo sapiens_hsa006201.15287047
45Gastric acid secretion_Homo sapiens_hsa049711.15123492
46Notch signaling pathway_Homo sapiens_hsa043301.13540893
47Insulin resistance_Homo sapiens_hsa049311.10821604
48Linoleic acid metabolism_Homo sapiens_hsa005911.04942289
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03771988
50Calcium signaling pathway_Homo sapiens_hsa040201.03509686
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02967981
52Tryptophan metabolism_Homo sapiens_hsa003801.02648677
53Bile secretion_Homo sapiens_hsa049761.02542388
54Dopaminergic synapse_Homo sapiens_hsa047281.02018640
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01593241
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.99715909
57Complement and coagulation cascades_Homo sapiens_hsa046100.99382806
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97608984
59Mineral absorption_Homo sapiens_hsa049780.97480369
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95483886
61Fatty acid elongation_Homo sapiens_hsa000620.95266912
62Carbon metabolism_Homo sapiens_hsa012000.94690484
63Vitamin B6 metabolism_Homo sapiens_hsa007500.94189661
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93910447
65Phenylalanine metabolism_Homo sapiens_hsa003600.93691603
66Oxytocin signaling pathway_Homo sapiens_hsa049210.93678528
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92766532
68* Prostate cancer_Homo sapiens_hsa052150.92334507
69Chemical carcinogenesis_Homo sapiens_hsa052040.91501855
70Biosynthesis of amino acids_Homo sapiens_hsa012300.91160408
71Glycerolipid metabolism_Homo sapiens_hsa005610.88686288
72Serotonergic synapse_Homo sapiens_hsa047260.88378355
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86158067
74Long-term depression_Homo sapiens_hsa047300.86092539
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86088275
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85198637
77Tyrosine metabolism_Homo sapiens_hsa003500.84991523
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84273906
79Cholinergic synapse_Homo sapiens_hsa047250.82291825
80Retinol metabolism_Homo sapiens_hsa008300.80987380
81cAMP signaling pathway_Homo sapiens_hsa040240.80610450
82Insulin secretion_Homo sapiens_hsa049110.79777472
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78324497
84Thyroid cancer_Homo sapiens_hsa052160.78268910
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78182090
86Endometrial cancer_Homo sapiens_hsa052130.77699934
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76277217
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.75663092
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.75426959
90Ovarian steroidogenesis_Homo sapiens_hsa049130.75013862
91Glucagon signaling pathway_Homo sapiens_hsa049220.73588906
92Prion diseases_Homo sapiens_hsa050200.72578520
93Cocaine addiction_Homo sapiens_hsa050300.72271964
94Thyroid hormone synthesis_Homo sapiens_hsa049180.69051644
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67896073
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.67590449
97Histidine metabolism_Homo sapiens_hsa003400.66829054
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66710335
99mTOR signaling pathway_Homo sapiens_hsa041500.66257702
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65865740
101Starch and sucrose metabolism_Homo sapiens_hsa005000.64708872
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.64570591
103GnRH signaling pathway_Homo sapiens_hsa049120.64457745
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62368095
105Tight junction_Homo sapiens_hsa045300.61765210
106Alzheimers disease_Homo sapiens_hsa050100.61165529
107Estrogen signaling pathway_Homo sapiens_hsa049150.60813599
108Melanogenesis_Homo sapiens_hsa049160.60403621
109Oxidative phosphorylation_Homo sapiens_hsa001900.60003435
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57136605
111ABC transporters_Homo sapiens_hsa020100.57111393
112Vibrio cholerae infection_Homo sapiens_hsa051100.56494177
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54412279
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51574133
115Gap junction_Homo sapiens_hsa045400.49053363
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48514989
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48035420
118Arachidonic acid metabolism_Homo sapiens_hsa005900.47506041
119Adherens junction_Homo sapiens_hsa045200.45868515
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44184263
121Cardiac muscle contraction_Homo sapiens_hsa042600.41431699
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40703789
123Glioma_Homo sapiens_hsa052140.40559449
124Insulin signaling pathway_Homo sapiens_hsa049100.40299367
125Vitamin digestion and absorption_Homo sapiens_hsa049770.40010027
126Choline metabolism in cancer_Homo sapiens_hsa052310.39980969
127Hedgehog signaling pathway_Homo sapiens_hsa043400.39765692
128Axon guidance_Homo sapiens_hsa043600.39088032
129Type II diabetes mellitus_Homo sapiens_hsa049300.38672843
130Pancreatic secretion_Homo sapiens_hsa049720.38236782
131Circadian rhythm_Homo sapiens_hsa047100.38209172
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37486020
133Dilated cardiomyopathy_Homo sapiens_hsa054140.34398149
134Fructose and mannose metabolism_Homo sapiens_hsa000510.33267927
135FoxO signaling pathway_Homo sapiens_hsa040680.33151228
136One carbon pool by folate_Homo sapiens_hsa006700.32147209
137Metabolic pathways_Homo sapiens_hsa011000.28637834
138Proteoglycans in cancer_Homo sapiens_hsa052050.27882965
139Pentose phosphate pathway_Homo sapiens_hsa000300.25358200
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24273487
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24047390
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23603417
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23551800
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23538922

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