ARAF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.25231160
2vocalization behavior (GO:0071625)5.03528499
3synaptic vesicle exocytosis (GO:0016079)4.75271233
4negative regulation of cell killing (GO:0031342)4.70833745
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70833745
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56105365
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52040595
8neutrophil activation involved in immune response (GO:0002283)4.39816516
9presynaptic membrane assembly (GO:0097105)4.39535043
10antigen processing and presentation of endogenous antigen (GO:0019883)4.37664591
11positive regulation of gamma-delta T cell activation (GO:0046645)4.37098561
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24486800
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24059225
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14485380
15regulation of synaptic vesicle exocytosis (GO:2000300)4.13809741
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.13018850
17negative regulation of erythrocyte differentiation (GO:0045647)4.11551892
18presynaptic membrane organization (GO:0097090)4.02307822
19gamma-aminobutyric acid signaling pathway (GO:0007214)3.94647251
20regulation of glutamate receptor signaling pathway (GO:1900449)3.94096818
21protein localization to synapse (GO:0035418)3.93174274
22neuronal action potential propagation (GO:0019227)3.92784032
23neurotransmitter secretion (GO:0007269)3.92047226
24response to peptidoglycan (GO:0032494)3.88326425
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84200913
26glutamate secretion (GO:0014047)3.79438429
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78856398
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76135359
29ATP hydrolysis coupled proton transport (GO:0015991)3.74527700
30energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.74527700
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.72313803
32neuron-neuron synaptic transmission (GO:0007270)3.72259523
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63565055
34regulation of synaptic vesicle transport (GO:1902803)3.62696034
35glutamate receptor signaling pathway (GO:0007215)3.58449721
36positive regulation by symbiont of host defense response (GO:0052509)3.57256898
37modulation by symbiont of host defense response (GO:0052031)3.57256898
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57256898
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57256898
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.57256898
41modulation by symbiont of host immune response (GO:0052553)3.57256898
42neurotransmitter-gated ion channel clustering (GO:0072578)3.54302083
43startle response (GO:0001964)3.53479364
44response to histamine (GO:0034776)3.53196365
45detection of bacterium (GO:0016045)3.52719928
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49402738
47postsynaptic membrane organization (GO:0001941)3.48318080
48positive regulation of synapse assembly (GO:0051965)3.48199036
49transferrin transport (GO:0033572)3.46558041
50detection of other organism (GO:0098543)3.46100959
51regulation of gamma-delta T cell activation (GO:0046643)3.44707626
52synaptic transmission, glutamatergic (GO:0035249)3.44046657
53NIK/NF-kappaB signaling (GO:0038061)3.42903527
54neurotransmitter transport (GO:0006836)3.42347625
55neuron recognition (GO:0008038)3.40899297
56detection of calcium ion (GO:0005513)3.40471008
57transmission of nerve impulse (GO:0019226)3.38969352
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38139026
59gamma-aminobutyric acid transport (GO:0015812)3.32545563
60regulation of gamma-delta T cell differentiation (GO:0045586)3.32217688
61regulation of glutamate secretion (GO:0014048)3.32199630
62locomotory exploration behavior (GO:0035641)3.31503611
63leukocyte aggregation (GO:0070486)3.29992839
64trivalent inorganic cation transport (GO:0072512)3.25183476
65ferric iron transport (GO:0015682)3.25183476
66immunoglobulin mediated immune response (GO:0016064)3.23779622
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22646136
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22314671
69long-term synaptic potentiation (GO:0060291)3.21207308
70synaptic vesicle maturation (GO:0016188)3.20782113
71ATP synthesis coupled proton transport (GO:0015986)3.16551275
72energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16551275
73regulation of neurotransmitter levels (GO:0001505)3.15609979
74female mating behavior (GO:0060180)3.13069987
75regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11329998
76pinocytosis (GO:0006907)3.08595803
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.08445263
78response to muramyl dipeptide (GO:0032495)3.08285372
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08239432
80exploration behavior (GO:0035640)3.05648519
81negative regulation of neurotransmitter transport (GO:0051589)3.03600106
82behavioral response to cocaine (GO:0048148)3.02785030
83regulation of vesicle fusion (GO:0031338)3.02770402
84regulation of postsynaptic membrane potential (GO:0060078)3.02753892
85positive regulation of amino acid transport (GO:0051957)3.02351327
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01784372
87macrophage activation involved in immune response (GO:0002281)3.00767305
88cerebellar granule cell differentiation (GO:0021707)2.98210224
89positive regulation of membrane potential (GO:0045838)2.97812296
90negative regulation of interleukin-12 production (GO:0032695)2.96417204
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96323648
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96174888
93striatum development (GO:0021756)2.96123970
94type I interferon signaling pathway (GO:0060337)2.95553412
95cellular response to type I interferon (GO:0071357)2.95553412
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93499270
97proline transport (GO:0015824)2.92611005
98response to type I interferon (GO:0034340)2.92292354
99long-term memory (GO:0007616)2.91692440
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.90957034
101lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90045681
102respiratory electron transport chain (GO:0022904)2.89891447
103neutrophil activation (GO:0042119)2.89183525
104regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88064905
105synaptic vesicle endocytosis (GO:0048488)2.87898312
106negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87326715
107regulation of female receptivity (GO:0045924)2.87142976
108regulation of synaptic transmission, GABAergic (GO:0032228)2.86523481
109regulation of protein kinase A signaling (GO:0010738)2.86366002
110response to cocaine (GO:0042220)2.86216555
111regulation of neuronal synaptic plasticity (GO:0048168)2.85808296
112regulation of dopamine metabolic process (GO:0042053)2.85515250
113regulation of catecholamine metabolic process (GO:0042069)2.85515250
114membrane hyperpolarization (GO:0060081)2.85326795
115synapse assembly (GO:0007416)2.84681446
116electron transport chain (GO:0022900)2.83362624
1173-UTR-mediated mRNA stabilization (GO:0070935)2.83336009
118germinal center formation (GO:0002467)2.83108327
119regulation of neurotransmitter secretion (GO:0046928)2.82039716
120NADH metabolic process (GO:0006734)2.81690312
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80786184
122detection of external biotic stimulus (GO:0098581)2.80197840
123succinate metabolic process (GO:0006105)2.79562101
124neuromuscular process controlling posture (GO:0050884)2.78893919
125establishment of synaptic vesicle localization (GO:0097480)2.76707755
126synaptic vesicle transport (GO:0048489)2.76707755
127regulation of mast cell degranulation (GO:0043304)2.76656026
128positive regulation of B cell differentiation (GO:0045579)2.76633665
129negative regulation of innate immune response (GO:0045824)2.76527474
130cellular extravasation (GO:0045123)2.76291361
131positive thymic T cell selection (GO:0045059)2.76201297
132granulocyte activation (GO:0036230)2.75654150
133regulation of interferon-beta biosynthetic process (GO:0045357)2.75387634
134activation of protein kinase A activity (GO:0034199)2.74922420
135regulation of B cell receptor signaling pathway (GO:0050855)2.74483713
136chaperone-mediated protein transport (GO:0072321)2.73383383
137mating behavior (GO:0007617)2.73322142
138synaptic transmission (GO:0007268)2.73032864
139long-chain fatty acid biosynthetic process (GO:0042759)2.72715088
140positive regulation of synapse maturation (GO:0090129)2.71829347
141synaptic transmission, dopaminergic (GO:0001963)2.71508413
142cerebellar Purkinje cell differentiation (GO:0021702)2.71195781
143membrane depolarization (GO:0051899)2.69685767
144mechanosensory behavior (GO:0007638)2.69364690
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.68923768
146axonal fasciculation (GO:0007413)2.68198425
147regulation of synapse assembly (GO:0051963)2.67895951
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.67718713
149behavioral defense response (GO:0002209)2.67685205
150positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67595731
151regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66735312
152modulation by symbiont of host cellular process (GO:0044068)2.65319151
153tolerance induction (GO:0002507)2.63311834
154modulation by virus of host process (GO:0019054)2.61468311
155negative regulation of phagocytosis (GO:0050765)2.61264460
156negative regulation of cytokine production involved in immune response (GO:0002719)2.60775264
157negative regulation of leukocyte mediated immunity (GO:0002704)2.60003519
158mannose metabolic process (GO:0006013)2.59464996
159regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58986046
160thymic T cell selection (GO:0045061)2.57442024
161regulation of necroptotic process (GO:0060544)2.55840510
162antigen processing and presentation via MHC class Ib (GO:0002475)2.55635079
163regulation of leukocyte degranulation (GO:0043300)2.55427765
164cellular response to virus (GO:0098586)2.54846799
165regulation of superoxide anion generation (GO:0032928)2.54548955
166regulation of T-helper 2 cell differentiation (GO:0045628)2.53353953
167regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52759077
168response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49331579
169response to host (GO:0075136)2.49331579
170response to host defenses (GO:0052200)2.49331579
171negative regulation of necroptotic process (GO:0060546)2.48638085
172response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47579468
173response to host immune response (GO:0052572)2.47579468
174regulation of T cell tolerance induction (GO:0002664)2.47455878
175myeloid cell activation involved in immune response (GO:0002275)2.46224140
176pentose-phosphate shunt (GO:0006098)2.45354953
177detection of biotic stimulus (GO:0009595)2.45303900
178negative thymic T cell selection (GO:0045060)2.44619809
179respiratory burst (GO:0045730)2.43673955
180negative regulation of interleukin-6 production (GO:0032715)2.42759895
181regulation of necrotic cell death (GO:0010939)2.40892254
182B cell mediated immunity (GO:0019724)2.39064222
183regulation of mast cell activation involved in immune response (GO:0033006)2.37960753
184myeloid dendritic cell differentiation (GO:0043011)2.35888429
185T cell selection (GO:0045058)2.34803136
186defense response to protozoan (GO:0042832)2.33166492
187interferon-gamma-mediated signaling pathway (GO:0060333)2.31704246
188regulation of natural killer cell mediated immunity (GO:0002715)2.30749242
189regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.30749242
190response to laminar fluid shear stress (GO:0034616)2.30486678
191negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29944023
192B cell receptor signaling pathway (GO:0050853)2.28705630
193positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.28007213
194regulation of antigen processing and presentation (GO:0002577)2.27941730
195myeloid dendritic cell activation (GO:0001773)2.27541148
196regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.27267581
197regulation of B cell differentiation (GO:0045577)2.27215529
198negative T cell selection (GO:0043383)2.26976011
199regulation of T cell mediated cytotoxicity (GO:0001914)2.25976738
200response to interleukin-15 (GO:0070672)2.25768870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04024968
2GBX2_23144817_ChIP-Seq_PC3_Human4.30084435
3TAF15_26573619_Chip-Seq_HEK293_Human3.00315680
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94715423
5VDR_21846776_ChIP-Seq_THP-1_Human2.89396038
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.87257504
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81109200
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69034759
9MYC_22102868_ChIP-Seq_BL_Human2.63208513
10REST_21632747_ChIP-Seq_MESCs_Mouse2.51394917
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.46556841
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46094659
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44243275
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39107745
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38112179
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34378949
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34039433
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.32511695
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32165808
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29091367
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27187224
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25310265
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25051878
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24749644
25LXR_22292898_ChIP-Seq_THP-1_Human2.24311504
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23040005
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23040005
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22466145
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.20393649
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17947980
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16623528
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.10535308
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10338121
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09256059
35VDR_24763502_ChIP-Seq_THP-1_Human2.09152724
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08022875
37MAF_26560356_Chip-Seq_TH1_Human2.06921245
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99865791
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98247263
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96742709
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96712889
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96635089
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96506844
44TCF7_22412390_ChIP-Seq_EML_Mouse1.94840577
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94781382
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94060971
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.92909351
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92090432
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89899833
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.89743913
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.88198934
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87470461
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84765122
54P300_19829295_ChIP-Seq_ESCs_Human1.84292665
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84071068
56UTX_26944678_Chip-Seq_JUKART_Human1.82725117
57SMAD4_21799915_ChIP-Seq_A2780_Human1.81273927
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.77596576
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76651206
60KDM2B_26808549_Chip-Seq_DND41_Human1.76282899
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74614941
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.73983344
63RACK7_27058665_Chip-Seq_MCF-7_Human1.73913673
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72633153
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72118491
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.71531251
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71283221
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70305088
69DROSHA_22980978_ChIP-Seq_HELA_Human1.70229200
70IGF1R_20145208_ChIP-Seq_DFB_Human1.69076492
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66864198
72AR_21572438_ChIP-Seq_LNCaP_Human1.66798452
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66773398
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65733000
75MAF_26560356_Chip-Seq_TH2_Human1.65563026
76VDR_22108803_ChIP-Seq_LS180_Human1.64928063
77SPI1_23547873_ChIP-Seq_NB4_Human1.63539725
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59897060
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.58608068
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.57154120
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56968733
82FUS_26573619_Chip-Seq_HEK293_Human1.54282222
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54106237
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53786000
85SPI1_23127762_ChIP-Seq_K562_Human1.53627899
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52898564
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51698971
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49780501
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49486357
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48433361
91ZNF274_21170338_ChIP-Seq_K562_Hela1.46938817
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.46217300
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.45626313
94ER_23166858_ChIP-Seq_MCF-7_Human1.45576993
95SCL_19346495_ChIP-Seq_HPC-7_Human1.45300003
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43730143
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43466985
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40311194
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40135275
100NCOR1_26117541_ChIP-Seq_K562_Human1.39893179
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39646093
102AR_25329375_ChIP-Seq_VCAP_Human1.39193637
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37840891
104RNF2_27304074_Chip-Seq_NSC_Mouse1.37299405
105MYB_26560356_Chip-Seq_TH2_Human1.37219685
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.36798773
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36674446
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36410372
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36183711
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36140642
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.35626240
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32535236
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31938815
114BCOR_27268052_Chip-Seq_Bcells_Human1.31366066
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31276372
116MYB_26560356_Chip-Seq_TH1_Human1.30969189
117BCL6_27268052_Chip-Seq_Bcells_Human1.30114230
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.28712416
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28588227
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.28386420
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28348973
122P68_20966046_ChIP-Seq_HELA_Human1.27900040
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27856050
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.27231455
125STAT3_23295773_ChIP-Seq_U87_Human1.26454673
126GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26020366
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.25893208
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25544636
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.23680222
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23091095
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22875758
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21688576
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21607065
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20477334
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19906063
136PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19219085
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18221512
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18118919
139TCF4_23295773_ChIP-Seq_U87_Human1.16891956
140RUNX2_22187159_ChIP-Seq_PCA_Human1.16263837
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14571801
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13493685
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13203687
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13186317
145GATA1_19941826_ChIP-Seq_K562_Human1.12987251
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12444955
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12404982
148KDM2B_26808549_Chip-Seq_JURKAT_Human1.11799414
149STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11623744
150ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10809839
151RUNX_20019798_ChIP-Seq_JUKART_Human1.10308431
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10217585
153ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09973277
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09865669
155NANOG_18555785_Chip-Seq_ESCs_Mouse1.09834911
156ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09399011
157ERG_21242973_ChIP-ChIP_JURKAT_Human1.08469680
158JUN_21703547_ChIP-Seq_K562_Human1.07688983
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07103295
160STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06859738
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06221021
162PRDM14_20953172_ChIP-Seq_ESCs_Human1.05829443
163CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05153485
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04397076
165CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04277429
166CTCF_26484167_Chip-Seq_Bcells_Mouse1.03826339
167LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03042999
168ESR2_21235772_ChIP-Seq_MCF-7_Human1.02511815
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02262629
170TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02115309
171CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01566618
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01537041
173CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01332268
174PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00902418
175ARNT_22903824_ChIP-Seq_MCF-7_Human1.00831219
176SMAD_19615063_ChIP-ChIP_OVARY_Human1.00819634
177* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00574400
178VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00451022
179P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00164012
180CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96893939
181KDM2B_26808549_Chip-Seq_REH_Human0.96691565
182BCAT_22108803_ChIP-Seq_LS180_Human0.96029882
183MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96014341
184MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95009246
185EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94780618
186* AR_19668381_ChIP-Seq_PC3_Human0.94386606
187MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93892917
188CBP_20019798_ChIP-Seq_JUKART_Human0.92896841
189IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92896841
190FLI1_21867929_ChIP-Seq_TH2_Mouse0.92616124
191NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92456825
192GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92026744
193AHR_22903824_ChIP-Seq_MCF-7_Human0.91393223
194* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90213302
195YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90010568
196FLI1_27457419_Chip-Seq_LIVER_Mouse0.89652463
197RING1B_27294783_Chip-Seq_ESCs_Mouse0.89496357
198P53_22387025_ChIP-Seq_ESCs_Mouse0.89191148
199HTT_18923047_ChIP-ChIP_STHdh_Human0.88933641
200EWS_26573619_Chip-Seq_HEK293_Human0.87283990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.65416352
2MP0004859_abnormal_synaptic_plasticity3.92139753
3MP0003436_decreased_susceptibility_to3.52623607
4MP0003635_abnormal_synaptic_transmissio3.46357095
5MP0009745_abnormal_behavioral_response3.16943970
6MP0009046_muscle_twitch3.16727066
7MP0002064_seizures3.08815359
8MP0005451_abnormal_body_composition3.08705789
9MP0001968_abnormal_touch/_nociception2.90849787
10MP0003303_peritoneal_inflammation2.86012838
11MP0004270_analgesia2.81277385
12MP0002063_abnormal_learning/memory/cond2.77096022
13MP0003724_increased_susceptibility_to2.72831941
14MP0006276_abnormal_autonomic_nervous2.69742454
15* MP0002572_abnormal_emotion/affect_behav2.65497643
16MP0002736_abnormal_nociception_after2.64895208
17MP0001835_abnormal_antigen_presentation2.64235009
18MP0002272_abnormal_nervous_system2.60534929
19MP0005058_abnormal_lysosome_morphology2.57555336
20MP0001529_abnormal_vocalization2.56951959
21MP0002735_abnormal_chemical_nociception2.54407912
22MP0002822_catalepsy2.45257562
23MP0002734_abnormal_mechanical_nocicepti2.42297111
24MP0001501_abnormal_sleep_pattern2.38791946
25MP0005464_abnormal_platelet_physiology2.34081589
26MP0003122_maternal_imprinting2.33971690
27MP0003191_abnormal_cellular_cholesterol2.33810765
28MP0001486_abnormal_startle_reflex2.30646088
29MP0002837_dystrophic_cardiac_calcinosis2.27930610
30MP0001440_abnormal_grooming_behavior2.27814109
31MP0003763_abnormal_thymus_physiology2.24393060
32MP0002419_abnormal_innate_immunity2.21879022
33MP0005000_abnormal_immune_tolerance2.20149855
34MP0004510_myositis2.20149650
35MP0005423_abnormal_somatic_nervous2.19055104
36MP0003300_gastrointestinal_ulcer2.18790878
37MP0005025_abnormal_response_to2.16717455
38MP0005646_abnormal_pituitary_gland2.16688098
39MP0009780_abnormal_chondrocyte_physiolo2.12646877
40MP0008260_abnormal_autophagy2.07380347
41MP0009785_altered_susceptibility_to2.05583222
42MP0009840_abnormal_foam_cell2.04325240
43MP0000685_abnormal_immune_system2.03640612
44* MP0002067_abnormal_sensory_capabilities2.01725636
45MP0005387_immune_system_phenotype2.00684822
46MP0001790_abnormal_immune_system2.00684822
47MP0009333_abnormal_splenocyte_physiolog1.99957186
48MP0001800_abnormal_humoral_immune1.99115105
49MP0005645_abnormal_hypothalamus_physiol1.98299087
50MP0002733_abnormal_thermal_nociception1.96257517
51MP0001905_abnormal_dopamine_level1.95238741
52MP0001970_abnormal_pain_threshold1.95142519
53MP0002148_abnormal_hypersensitivity_rea1.93605327
54MP0004947_skin_inflammation1.91210931
55MP0002723_abnormal_immune_serum1.87839513
56MP0004142_abnormal_muscle_tone1.86658015
57MP0001533_abnormal_skeleton_physiology1.86605298
58MP0005671_abnormal_response_to1.86545957
59MP0006082_CNS_inflammation1.86464091
60MP0009278_abnormal_bone_marrow1.83539942
61MP0005386_behavior/neurological_phenoty1.82469294
62MP0004924_abnormal_behavior1.82469294
63MP0002452_abnormal_antigen_presenting1.82114885
64MP0002909_abnormal_adrenal_gland1.81817018
65MP0002420_abnormal_adaptive_immunity1.79094370
66MP0001819_abnormal_immune_cell1.77339415
67MP0001984_abnormal_olfaction1.77244732
68MP0010386_abnormal_urinary_bladder1.74320644
69MP0003172_abnormal_lysosome_physiology1.74231504
70MP0010155_abnormal_intestine_physiology1.72815996
71MP0002184_abnormal_innervation1.68215568
72MP0002557_abnormal_social/conspecific_i1.66577662
73MP0002876_abnormal_thyroid_physiology1.64747024
74MP0000013_abnormal_adipose_tissue1.63572025
75MP0001873_stomach_inflammation1.60759479
76MP0003329_amyloid_beta_deposits1.59310134
77MP0000858_altered_metastatic_potential1.57092917
78MP0003705_abnormal_hypodermis_morpholog1.56665640
79MP0002398_abnormal_bone_marrow1.54560195
80MP0003787_abnormal_imprinting1.52701340
81MP0001502_abnormal_circadian_rhythm1.47797983
82MP0005551_abnormal_eye_electrophysiolog1.47599597
83MP0002405_respiratory_system_inflammati1.47564781
84MP0001188_hyperpigmentation1.44570441
85MP0000778_abnormal_nervous_system1.44335927
86MP0001845_abnormal_inflammatory_respons1.43041708
87MP0000716_abnormal_immune_system1.42440899
88MP0008569_lethality_at_weaning1.40578050
89MP0005397_hematopoietic_system_phenotyp1.39618310
90MP0001545_abnormal_hematopoietic_system1.39618310
91MP0003879_abnormal_hair_cell1.35147452
92MP0003806_abnormal_nucleotide_metabolis1.35094167
93MP0001851_eye_inflammation1.32746443
94* MP0002722_abnormal_immune_system1.30967939
95MP0008469_abnormal_protein_level1.30718109
96* MP0002066_abnormal_motor_capabilities/c1.30158472
97MP0001853_heart_inflammation1.28689744
98MP0003075_altered_response_to1.28464982
99MP0000689_abnormal_spleen_morphology1.28456817
100MP0001986_abnormal_taste_sensitivity1.28324271
101MP0006072_abnormal_retinal_apoptosis1.28125030
102MP0002429_abnormal_blood_cell1.27192713
103MP0000955_abnormal_spinal_cord1.26910654
104MP0002882_abnormal_neuron_morphology1.25958903
105MP0000465_gastrointestinal_hemorrhage1.25944113
106MP0008004_abnormal_stomach_pH1.23279515
107MP0003828_pulmonary_edema1.23194365
108MP0002998_abnormal_bone_remodeling1.22489407
109MP0003566_abnormal_cell_adhesion1.20457166
110MP0003183_abnormal_peptide_metabolism1.20116841
111MP0002132_abnormal_respiratory_system1.19810596
112MP0004811_abnormal_neuron_physiology1.19670118
113* MP0000703_abnormal_thymus_morphology1.18888734
114MP0002229_neurodegeneration1.17237105
115MP0002396_abnormal_hematopoietic_system1.16495216
116MP0000343_altered_response_to1.16335410
117MP0004185_abnormal_adipocyte_glucose1.15974580
118MP0003656_abnormal_erythrocyte_physiolo1.14856108
119MP0002638_abnormal_pupillary_reflex1.14853738
120MP0000751_myopathy1.14205638
121MP0002933_joint_inflammation1.14014396
122MP0004043_abnormal_pH_regulation1.13152685
123MP0005379_endocrine/exocrine_gland_phen1.09878152
124MP0009764_decreased_sensitivity_to1.08717654
125MP0005083_abnormal_biliary_tract1.08065138
126MP0004742_abnormal_vestibular_system1.07887476
127MP0003866_abnormal_defecation1.03664216
128MP0005535_abnormal_body_temperature1.03451958
129MP0005166_decreased_susceptibility_to1.02087680
130MP0000490_abnormal_crypts_of1.00306372
131MP0003453_abnormal_keratinocyte_physiol0.99284395
132MP0004145_abnormal_muscle_electrophysio0.98030107
133MP0000631_abnormal_neuroendocrine_gland0.97289165
134MP0005076_abnormal_cell_differentiation0.97108050
135MP0003633_abnormal_nervous_system0.96194883
136MP0005666_abnormal_adipose_tissue0.95948965
137MP0001849_ear_inflammation0.95769502
138* MP0002069_abnormal_eating/drinking_beha0.94299487
139MP0002166_altered_tumor_susceptibility0.94125690
140MP0001963_abnormal_hearing_physiology0.92885046
141MP0005390_skeleton_phenotype0.92385982
142MP0002877_abnormal_melanocyte_morpholog0.92338684
143MP0004858_abnormal_nervous_system0.91102062
144MP0005360_urolithiasis0.90246014
145MP0008872_abnormal_physiological_respon0.89729693
146MP0003091_abnormal_cell_migration0.88827818
147MP0004085_abnormal_heartbeat0.87176553
148MP0003631_nervous_system_phenotype0.86930862
149MP0004885_abnormal_endolymph0.86048490
150MP0003634_abnormal_glial_cell0.85760729
151MP0001664_abnormal_digestion0.85521649
152MP0001663_abnormal_digestive_system0.85332828
153MP0002138_abnormal_hepatobiliary_system0.84891393
154MP0002152_abnormal_brain_morphology0.84739859
155MP0005253_abnormal_eye_physiology0.84162537
156MP0005165_increased_susceptibility_to0.84095999
157MP0000750_abnormal_muscle_regeneration0.83278976
158MP0009763_increased_sensitivity_to0.83043062
159MP0000249_abnormal_blood_vessel0.82894000
160MP0002752_abnormal_somatic_nervous0.82161555
161MP0004808_abnormal_hematopoietic_stem0.82154104
162MP0005330_cardiomyopathy0.81557562
163MP0005375_adipose_tissue_phenotype0.81276231
164MP0002139_abnormal_hepatobiliary_system0.80292813
165MP0000759_abnormal_skeletal_muscle0.78304614
166MP0000747_muscle_weakness0.77985020
167MP0000920_abnormal_myelination0.76545420
168MP0000609_abnormal_liver_physiology0.76515917
169MP0003795_abnormal_bone_structure0.75911095
170MP0000749_muscle_degeneration0.75345938
171MP0004215_abnormal_myocardial_fiber0.75279619
172MP0006036_abnormal_mitochondrial_physio0.75006649
173MP0005319_abnormal_enzyme/_coenzyme0.74395835
174MP0004233_abnormal_muscle_weight0.74287342
175MP0006035_abnormal_mitochondrial_morpho0.73666776
176MP0005023_abnormal_wound_healing0.73627788
177MP0003195_calcinosis0.73138535
178MP0002090_abnormal_vision0.72302063
179MP0003121_genomic_imprinting0.71937604
180MP0005409_darkened_coat_color0.69966077
181MP0004036_abnormal_muscle_relaxation0.69845337
182MP0003690_abnormal_glial_cell0.69742161
183MP0008874_decreased_physiological_sensi0.69719450
184MP0000604_amyloidosis0.69335486
185MP0003632_abnormal_nervous_system0.67173664
186MP0000026_abnormal_inner_ear0.63558842
187MP0002693_abnormal_pancreas_physiology0.59297147
188MP0005394_taste/olfaction_phenotype0.58748443
189MP0005499_abnormal_olfactory_system0.58748443
190MP0005171_absent_coat_pigmentation0.57657454
191MP0000230_abnormal_systemic_arterial0.57298868
192MP0002078_abnormal_glucose_homeostasis0.57189590
193MP0002332_abnormal_exercise_endurance0.56780450
194MP0001943_abnormal_respiration0.55850428
195MP0001485_abnormal_pinna_reflex0.55705530
196MP0000538_abnormal_urinary_bladder0.55535466

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.63057855
2Atonic seizures (HP:0010819)5.43601202
3Epileptic encephalopathy (HP:0200134)4.70537615
4Focal seizures (HP:0007359)4.58266597
5Febrile seizures (HP:0002373)4.40046143
6Hyperventilation (HP:0002883)4.25707395
7Absence seizures (HP:0002121)4.19703398
8Visual hallucinations (HP:0002367)4.17474780
9Eczematoid dermatitis (HP:0000976)4.14788353
10Acute necrotizing encephalopathy (HP:0006965)4.00995818
11Dialeptic seizures (HP:0011146)3.85498851
12Abnormal mitochondria in muscle tissue (HP:0008316)3.84465849
13Myokymia (HP:0002411)3.72399290
14Recurrent abscess formation (HP:0002722)3.65730883
15Pheochromocytoma (HP:0002666)3.61078464
16Progressive macrocephaly (HP:0004481)3.53014332
17Abnormality of macrophages (HP:0004311)3.48106934
18Generalized tonic-clonic seizures (HP:0002069)3.46734211
19Neuroendocrine neoplasm (HP:0100634)3.45017220
20Mitochondrial inheritance (HP:0001427)3.22944392
21Abnormal hair whorl (HP:0010721)3.21335931
22Myositis (HP:0100614)3.19715320
23Elevated erythrocyte sedimentation rate (HP:0003565)3.19665810
24Acute encephalopathy (HP:0006846)3.15251472
25Recurrent gram-negative bacterial infections (HP:0005420)3.14432599
26Progressive cerebellar ataxia (HP:0002073)3.13683563
27Limb dystonia (HP:0002451)3.09124884
28Petechiae (HP:0000967)3.06971551
29Gait imbalance (HP:0002141)3.02183337
30Exercise-induced myalgia (HP:0003738)3.00816487
31Prolonged bleeding time (HP:0003010)2.99869899
32Broad-based gait (HP:0002136)2.99185285
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.98645307
34Recurrent bacterial skin infections (HP:0005406)2.92548142
35Distal lower limb muscle weakness (HP:0009053)2.90405087
36Epileptiform EEG discharges (HP:0011182)2.87472868
37Obstructive lung disease (HP:0006536)2.83482772
38Chronic obstructive pulmonary disease (HP:0006510)2.83482772
39Polyphagia (HP:0002591)2.82756983
40Medial flaring of the eyebrow (HP:0010747)2.79079996
41Increased connective tissue (HP:0009025)2.78785819
42EEG with generalized epileptiform discharges (HP:0011198)2.78626778
43Hypothermia (HP:0002045)2.77824707
44Orchitis (HP:0100796)2.77722906
45Congenital primary aphakia (HP:0007707)2.76178148
46Progressive inability to walk (HP:0002505)2.74248839
47Purpura (HP:0000979)2.72816614
48Anxiety (HP:0000739)2.72751681
49Epistaxis (HP:0000421)2.69967028
50Nemaline bodies (HP:0003798)2.68046720
51Cellulitis (HP:0100658)2.67908550
52Increased CSF lactate (HP:0002490)2.66052932
53Myopathic facies (HP:0002058)2.64972863
54Increased IgE level (HP:0003212)2.64637196
55Hepatocellular necrosis (HP:0001404)2.64226937
56Muscle fiber inclusion bodies (HP:0100299)2.62904158
57Abnormality of skeletal muscle fiber size (HP:0012084)2.62457959
58Hypsarrhythmia (HP:0002521)2.62198601
59Poor suck (HP:0002033)2.62146537
60Mediastinal lymphadenopathy (HP:0100721)2.61379717
61Dysostosis multiplex (HP:0000943)2.60670276
62Distal lower limb amyotrophy (HP:0008944)2.59930546
63Increased serum ferritin (HP:0003281)2.59744736
64Fatigue (HP:0012378)2.59689432
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57158733
66Abnormal eating behavior (HP:0100738)2.55756849
67Nephrogenic diabetes insipidus (HP:0009806)2.54235792
68Failure to thrive in infancy (HP:0001531)2.53458873
69Spontaneous hematomas (HP:0007420)2.52188765
70Hepatosplenomegaly (HP:0001433)2.49269484
71Meningitis (HP:0001287)2.48311191
72Truncal ataxia (HP:0002078)2.48096082
73Gastrointestinal inflammation (HP:0004386)2.48010012
74Abnormality of liposaccharide metabolism (HP:0010968)2.47159681
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.47159681
76Abnormality of glycolipid metabolism (HP:0010969)2.47159681
77Colitis (HP:0002583)2.46125655
78Systemic lupus erythematosus (HP:0002725)2.45322458
79Increased IgM level (HP:0003496)2.43707435
80Gingivitis (HP:0000230)2.43251339
81Optic disc pallor (HP:0000543)2.42863359
82Oligomenorrhea (HP:0000876)2.41258651
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39807864
84Supranuclear gaze palsy (HP:0000605)2.37291707
85Inflammation of the large intestine (HP:0002037)2.36613735
86Excessive salivation (HP:0003781)2.36231130
87Drooling (HP:0002307)2.36231130
88Hypertensive crisis (HP:0100735)2.36119900
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.36096431
90Stomatitis (HP:0010280)2.35265732
91Recurrent fungal infections (HP:0002841)2.34402022
92Genital tract atresia (HP:0001827)2.33265234
93Vaginal atresia (HP:0000148)2.32986384
94Gastrointestinal infarctions (HP:0005244)2.32739824
95Gingival bleeding (HP:0000225)2.32691709
96Increased variability in muscle fiber diameter (HP:0003557)2.32218112
97Rhabdomyolysis (HP:0003201)2.27852762
98Gaze-evoked nystagmus (HP:0000640)2.26856300
99Increased cerebral lipofuscin (HP:0011813)2.26720150
100Recurrent viral infections (HP:0004429)2.26637757
101Amblyopia (HP:0000646)2.26618404
102Chest pain (HP:0100749)2.26233828
103Abnormal social behavior (HP:0012433)2.26227382
104Impaired social interactions (HP:0000735)2.26227382
105Asymmetric septal hypertrophy (HP:0001670)2.25895861
106Vasculitis (HP:0002633)2.24988729
107Poor eye contact (HP:0000817)2.24844033
108Vertebral compression fractures (HP:0002953)2.24734594
109Neurofibrillary tangles (HP:0002185)2.24028474
110Depression (HP:0000716)2.23751346
111Urticaria (HP:0001025)2.23003743
112Granulocytopenia (HP:0001913)2.22478579
113Optic neuritis (HP:0100653)2.21552733
114Retrobulbar optic neuritis (HP:0100654)2.21552733
115Protruding tongue (HP:0010808)2.21414266
116Blue irides (HP:0000635)2.20822938
117Cerebral inclusion bodies (HP:0100314)2.20272678
118Agitation (HP:0000713)2.19819357
119Dysdiadochokinesis (HP:0002075)2.19013571
120Abnormality of binocular vision (HP:0011514)2.18664638
121Diplopia (HP:0000651)2.18664638
122Amyloidosis (HP:0011034)2.17989816
123Generalized myoclonic seizures (HP:0002123)2.17748651
124Dysmetria (HP:0001310)2.17664142
125Psychosis (HP:0000709)2.17081034
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16054248
127Degeneration of the lateral corticospinal tracts (HP:0002314)2.16054248
128Abnormality of iron homeostasis (HP:0011031)2.14838552
129Type 1 muscle fiber predominance (HP:0003803)2.14597136
130Esotropia (HP:0000565)2.13338200
131Inability to walk (HP:0002540)2.12450890
132Hypergammaglobulinemia (HP:0010702)2.10234550
133Loss of speech (HP:0002371)2.10194462
134Gastrointestinal stroma tumor (HP:0100723)2.10184093
135Interstitial pulmonary disease (HP:0006530)2.09681240
136Leukodystrophy (HP:0002415)2.08830264
137Abnormality of the corticospinal tract (HP:0002492)2.07216752
138Scanning speech (HP:0002168)2.06972433
139Pustule (HP:0200039)2.06321495
140Hypertriglyceridemia (HP:0002155)2.06266028
141Absent speech (HP:0001344)2.04831020
142Specific learning disability (HP:0001328)2.04680971
143Impaired vibration sensation in the lower limbs (HP:0002166)2.04173074
144Ankle clonus (HP:0011448)2.03806646
145Ragged-red muscle fibers (HP:0003200)2.03655882
146Encephalitis (HP:0002383)2.03333258
147Akinesia (HP:0002304)2.02816457
148Spastic gait (HP:0002064)2.00738278
149Polycythemia (HP:0001901)2.00403337
150Hemiparesis (HP:0001269)2.00332115
151Abnormal gallbladder physiology (HP:0012438)1.98155944
152Cholecystitis (HP:0001082)1.98155944
153Pulmonary infiltrates (HP:0002113)1.98009475
154Resting tremor (HP:0002322)1.97537722
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.96438910
156Hepatic necrosis (HP:0002605)1.95838456
157Cerebral edema (HP:0002181)1.94118227
158Recurrent skin infections (HP:0001581)1.94004121
159Poor coordination (HP:0002370)1.93471088
160Hemorrhage of the eye (HP:0011885)1.93202004
161Bradykinesia (HP:0002067)1.92874691
162Muscle fiber splitting (HP:0003555)1.92820563
163Abnormal platelet volume (HP:0011876)1.92471785
164Abnormality of calcium-phosphate metabolism (HP:0100530)1.91838465
165Achilles tendon contracture (HP:0001771)1.89952761
166Round ear (HP:0100830)1.89491773
167Polygenic inheritance (HP:0010982)1.89453236
168Abnormal platelet function (HP:0011869)1.88624519
169Impaired platelet aggregation (HP:0003540)1.88624519
170X-linked dominant inheritance (HP:0001423)1.88603126
171Arterial thrombosis (HP:0004420)1.87696289
172Menorrhagia (HP:0000132)1.87231571
173Abnormality of glycolysis (HP:0004366)1.86835364
174Increased serum pyruvate (HP:0003542)1.86835364
175Bulbar palsy (HP:0001283)1.86727345
176Abnormality of the Achilles tendon (HP:0005109)1.86594476
177Hypoventilation (HP:0002791)1.86505888
178Delusions (HP:0000746)1.85884899
179Abnormality of polysaccharide metabolism (HP:0011012)1.85617549
180Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85617549
181Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85617549
182Metaphyseal cupping (HP:0003021)1.85137030
183Agammaglobulinemia (HP:0004432)1.84903517
184Vacuolated lymphocytes (HP:0001922)1.83934210
185Fetal akinesia sequence (HP:0001989)1.83786623
186Action tremor (HP:0002345)1.82077694
187Recurrent cutaneous fungal infections (HP:0011370)1.81480977
188Chronic mucocutaneous candidiasis (HP:0002728)1.81480977
189Hyperthyroidism (HP:0000836)1.81346734
190Axonal loss (HP:0003447)1.80582995
191Difficulty climbing stairs (HP:0003551)1.80402723
192Cerebral hemorrhage (HP:0001342)1.80393253
193Easy fatigability (HP:0003388)1.80387896
194Narrow nasal bridge (HP:0000446)1.78918989
195Retinal dysplasia (HP:0007973)1.78111108
196Status epilepticus (HP:0002133)1.76435628
197Postural tremor (HP:0002174)1.76190150
198Lactic acidosis (HP:0003128)1.75615648
199Insidious onset (HP:0003587)1.74328858
200Termporal pattern (HP:0011008)1.74328858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.75995423
2NTRK33.83840104
3MAP3K123.63562374
4ERN13.55325663
5MAP3K43.19153395
6MAP4K13.18053314
7MAP2K73.03002780
8TRIB32.90008309
9MAP2K32.62580848
10EPHA42.61682088
11IRAK32.46759938
12PNCK2.37641145
13MARK12.24710956
14SMG12.23267841
15MAP3K92.15661720
16NME22.12286456
17TESK22.08527208
18MAP2K42.08037091
19TNIK2.05388775
20TYK22.02701699
21TBK11.98493886
22SIK11.97049810
23MINK11.93043503
24ARAF1.91553210
25TTN1.91537920
26NTRK21.83822310
27TAOK21.77750114
28MAP3K31.75495758
29ZAP701.74309441
30GRK51.73040322
31PLK21.69192194
32OXSR11.68530424
33MAP3K111.67363761
34EPHB11.65166725
35CDK191.64579471
36NME11.62899736
37IRAK41.60948551
38AKT31.58453053
39TESK11.57994976
40GRK61.56054685
41MAPK131.54828811
42MAP3K141.53608313
43DAPK21.52446736
44NTRK11.51369941
45CSK1.39769857
46TAOK11.37177955
47BLK1.30778162
48JAK31.29682522
49RIPK41.28835549
50INSRR1.28304292
51IKBKE1.27647435
52ICK1.27472957
53CDK51.26850407
54DAPK11.25098438
55PRKCG1.24229961
56PRPF4B1.21330121
57UHMK11.20318080
58CAMK2A1.20297178
59IKBKB1.16082850
60STK391.15818242
61CAMK2B1.14873333
62BTK1.13779855
63TSSK61.13195676
64SIK31.13163498
65GRK71.12938275
66WNK31.12492701
67FES1.12256000
68PIM21.11208733
69FGFR41.10489046
70BCR1.08606578
71MAP3K131.08067263
72RIPK11.03645007
73CSF1R1.03431229
74WNK41.02287282
75PRKCE1.00282876
76SGK4940.99551460
77SGK2230.99551460
78TXK0.99424758
79PRKD20.98823130
80TNK20.97778682
81SIK20.95943757
82HCK0.94660660
83KIT0.92889497
84CAMKK20.91370192
85LRRK20.90440637
86CDC42BPA0.90431629
87PHKG10.90385652
88PHKG20.90385652
89ADRBK20.89646929
90CAMK2D0.89605376
91KDR0.88450516
92PAK60.88349426
93STK100.87437174
94PAK40.87133729
95PTK60.87128146
96SYK0.86670897
97TAOK30.85544453
98BMX0.85331710
99EEF2K0.84280985
100BMPR20.83242951
101JAK10.83209830
102MYLK0.82356232
103CDK120.81409468
104MAPK120.80589932
105MAPK110.78436888
106EPHA20.78308542
107MUSK0.77163127
108HIPK20.76990625
109SGK20.76240140
110BRAF0.75660576
111TGFBR20.74867457
112PAK30.74151943
113MAP2K20.73988038
114CAMK2G0.73486431
115KSR10.72948747
116OBSCN0.72678496
117CSNK1G20.72396174
118ADRBK10.72366191
119FGR0.72261057
120PDPK10.71199593
121PKN20.69648210
122LCK0.69298056
123KSR20.68651573
124LYN0.67083772
125MAP3K100.66715116
126MARK30.66518714
127LMTK20.66316961
128PRKCH0.66151488
129DYRK1A0.65774642
130MAPKAPK30.65540123
131JAK20.63969264
132CDK140.63802851
133MAPKAPK20.63681414
134BMPR1B0.63600572
135CDK180.62956378
136VRK20.62937927
137STK160.60497997
138PTK2B0.60283152
139MAPK70.60038840
140MAPK150.59774107
141CCNB10.59718816
142RPS6KL10.59570739
143RPS6KC10.59570739
144PKN10.58390179
145FER0.58338634
146CSNK1G30.57731795
147BCKDK0.57543428
148CAMK10.57320081
149CDK150.56893881
150SGK10.55652148
151CDK40.55525111
152MAP3K70.55343016
153PDK10.55292079
154MAP3K80.54938912
155MOS0.54287762
156PRKACA0.53726387
157WNK10.53130201
158CAMK1G0.52552419
159MAPKAPK50.52389433
160IRAK20.50387866
161MATK0.49741815
162TEC0.49282551
163CDK11A0.48037040
164ERBB40.47335781
165RPS6KA20.46306559
166PRKD30.45013984
167MTOR0.44876494
168PIK3CG0.44872637
169ITK0.44803917
170MAP3K20.43857689
171ROCK20.43481391
172SCYL20.43249544
173IRAK10.42373801
174PDK30.42230239
175PDK40.42230239
176MAPK40.41902797
177DYRK1B0.40277845
178RPS6KA60.39773187
179MAP3K60.39225889
180NEK60.38186297
181PRKCA0.36872759
182MARK20.36840539
183STK110.36581889
184RET0.36445275
185CAMKK10.36339750
186MAP3K10.36283597
187PRKG10.35631683
188PRKCQ0.35001059
189FYN0.34777697

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98588880
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54826440
3Collecting duct acid secretion_Homo sapiens_hsa049663.28410736
4Oxidative phosphorylation_Homo sapiens_hsa001903.25852607
5Other glycan degradation_Homo sapiens_hsa005112.99107110
6GABAergic synapse_Homo sapiens_hsa047272.77590199
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74974680
8Osteoclast differentiation_Homo sapiens_hsa043802.42650999
9Parkinsons disease_Homo sapiens_hsa050122.41178265
10Morphine addiction_Homo sapiens_hsa050322.38487154
11Leishmaniasis_Homo sapiens_hsa051402.36485177
12Vibrio cholerae infection_Homo sapiens_hsa051102.23510751
13Circadian entrainment_Homo sapiens_hsa047132.15504249
14Alzheimers disease_Homo sapiens_hsa050102.13966861
15Amphetamine addiction_Homo sapiens_hsa050312.09493937
16Staphylococcus aureus infection_Homo sapiens_hsa051502.07191822
17Glutamatergic synapse_Homo sapiens_hsa047242.06429834
18Taste transduction_Homo sapiens_hsa047422.05049599
19B cell receptor signaling pathway_Homo sapiens_hsa046622.00390031
20* Acute myeloid leukemia_Homo sapiens_hsa052211.99606170
21Insulin secretion_Homo sapiens_hsa049111.96485077
22Olfactory transduction_Homo sapiens_hsa047401.95458852
23Allograft rejection_Homo sapiens_hsa053301.92498350
24Dopaminergic synapse_Homo sapiens_hsa047281.91088931
25Primary immunodeficiency_Homo sapiens_hsa053401.90937965
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88873196
27Graft-versus-host disease_Homo sapiens_hsa053321.84720487
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.83708768
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83215104
30* Long-term potentiation_Homo sapiens_hsa047201.82168595
31* Serotonergic synapse_Homo sapiens_hsa047261.80653079
32Autoimmune thyroid disease_Homo sapiens_hsa053201.78347643
33Viral myocarditis_Homo sapiens_hsa054161.74961073
34Malaria_Homo sapiens_hsa051441.72756053
35Cocaine addiction_Homo sapiens_hsa050301.64965865
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63158807
37Pentose phosphate pathway_Homo sapiens_hsa000301.60920965
38Tuberculosis_Homo sapiens_hsa051521.56956623
39Salivary secretion_Homo sapiens_hsa049701.56318735
40Cardiac muscle contraction_Homo sapiens_hsa042601.56233890
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54299390
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53800408
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52046225
44Huntingtons disease_Homo sapiens_hsa050161.51945867
45Measles_Homo sapiens_hsa051621.50968073
46Phototransduction_Homo sapiens_hsa047441.50669184
47* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50481783
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49841236
49Cholinergic synapse_Homo sapiens_hsa047251.49018528
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47729004
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.43344916
52Herpes simplex infection_Homo sapiens_hsa051681.43198607
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41975456
54Renin secretion_Homo sapiens_hsa049241.41610931
55Toxoplasmosis_Homo sapiens_hsa051451.40923885
56Influenza A_Homo sapiens_hsa051641.39887228
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38460676
58TNF signaling pathway_Homo sapiens_hsa046681.35546280
59Calcium signaling pathway_Homo sapiens_hsa040201.35148674
60Pertussis_Homo sapiens_hsa051331.34376093
61Fructose and mannose metabolism_Homo sapiens_hsa000511.33884740
62T cell receptor signaling pathway_Homo sapiens_hsa046601.33584032
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32525443
64Antigen processing and presentation_Homo sapiens_hsa046121.31167870
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31037602
66* Long-term depression_Homo sapiens_hsa047301.30807169
67Hematopoietic cell lineage_Homo sapiens_hsa046401.30119322
68Legionellosis_Homo sapiens_hsa051341.29111852
69Lysosome_Homo sapiens_hsa041421.26983364
70* Chronic myeloid leukemia_Homo sapiens_hsa052201.25526939
71Gastric acid secretion_Homo sapiens_hsa049711.25408677
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23528413
73Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22764935
74Shigellosis_Homo sapiens_hsa051311.21976628
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.21009154
76Hepatitis B_Homo sapiens_hsa051611.20915086
77Protein export_Homo sapiens_hsa030601.20873383
78Intestinal immune network for IgA production_Homo sapiens_hsa046721.19543491
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17857096
80Galactose metabolism_Homo sapiens_hsa000521.16852609
81* Hepatitis C_Homo sapiens_hsa051601.16108529
82* Non-small cell lung cancer_Homo sapiens_hsa052231.15670108
83Apoptosis_Homo sapiens_hsa042101.13247899
84NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09770363
85Cyanoamino acid metabolism_Homo sapiens_hsa004601.08997523
86VEGF signaling pathway_Homo sapiens_hsa043701.07964601
87Oxytocin signaling pathway_Homo sapiens_hsa049211.07662322
88* Pancreatic cancer_Homo sapiens_hsa052121.06963137
89Platelet activation_Homo sapiens_hsa046111.06718890
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04810986
91Asthma_Homo sapiens_hsa053101.04622091
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02867428
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01910535
94Rheumatoid arthritis_Homo sapiens_hsa053231.01890382
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00991884
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.99995760
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.99421892
98Chemokine signaling pathway_Homo sapiens_hsa040620.98356467
99Butanoate metabolism_Homo sapiens_hsa006500.97190907
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95745552
101Notch signaling pathway_Homo sapiens_hsa043300.94023115
102Fatty acid elongation_Homo sapiens_hsa000620.91679716
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91060778
104Type I diabetes mellitus_Homo sapiens_hsa049400.90516848
105Insulin resistance_Homo sapiens_hsa049310.90429604
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89261166
107Salmonella infection_Homo sapiens_hsa051320.89014677
108Gap junction_Homo sapiens_hsa045400.87707610
109Amoebiasis_Homo sapiens_hsa051460.86889880
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.86820084
111Epstein-Barr virus infection_Homo sapiens_hsa051690.84571296
112GnRH signaling pathway_Homo sapiens_hsa049120.84358927
113HTLV-I infection_Homo sapiens_hsa051660.83197331
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82171018
115Viral carcinogenesis_Homo sapiens_hsa052030.80358107
116Sulfur metabolism_Homo sapiens_hsa009200.79534388
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79469318
118African trypanosomiasis_Homo sapiens_hsa051430.79090008
119Sulfur relay system_Homo sapiens_hsa041220.78811018
120cAMP signaling pathway_Homo sapiens_hsa040240.77348125
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77224432
122Type II diabetes mellitus_Homo sapiens_hsa049300.75973270
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73163583
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73071740
125Endocytosis_Homo sapiens_hsa041440.72156813
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.71872775
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71112585
128Axon guidance_Homo sapiens_hsa043600.70665818
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70548240
130Complement and coagulation cascades_Homo sapiens_hsa046100.70486673
131Phagosome_Homo sapiens_hsa041450.69963023
132Pyruvate metabolism_Homo sapiens_hsa006200.69962124
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.69353548
134* Bladder cancer_Homo sapiens_hsa052190.68127851
135* Insulin signaling pathway_Homo sapiens_hsa049100.67943996
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67500436
137Biosynthesis of amino acids_Homo sapiens_hsa012300.66535965
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65687508
139Pancreatic secretion_Homo sapiens_hsa049720.65680306
140* Vascular smooth muscle contraction_Homo sapiens_hsa042700.65651389
141Estrogen signaling pathway_Homo sapiens_hsa049150.64891102
142Carbon metabolism_Homo sapiens_hsa012000.64556447
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62806397
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62315852
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61516165
146Thyroid cancer_Homo sapiens_hsa052160.59513441
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58987042
148Small cell lung cancer_Homo sapiens_hsa052220.57987963
149Regulation of autophagy_Homo sapiens_hsa041400.57552115
150Thyroid hormone synthesis_Homo sapiens_hsa049180.56806297
151Melanogenesis_Homo sapiens_hsa049160.56588972
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54489874
153Prolactin signaling pathway_Homo sapiens_hsa049170.51303622
154* Renal cell carcinoma_Homo sapiens_hsa052110.51221232
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49442322
156mTOR signaling pathway_Homo sapiens_hsa041500.47908356
157Glucagon signaling pathway_Homo sapiens_hsa049220.47039527
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47009534
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.46318283
160Dilated cardiomyopathy_Homo sapiens_hsa054140.44650491
161HIF-1 signaling pathway_Homo sapiens_hsa040660.44158750
162Circadian rhythm_Homo sapiens_hsa047100.43917417
163Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41777990
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41284688
165* ErbB signaling pathway_Homo sapiens_hsa040120.39604946
166Phenylalanine metabolism_Homo sapiens_hsa003600.37684863
167MAPK signaling pathway_Homo sapiens_hsa040100.37292950
168Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35376995
169Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34223067
170Ras signaling pathway_Homo sapiens_hsa040140.32981988
171Prion diseases_Homo sapiens_hsa050200.31332704
172Inositol phosphate metabolism_Homo sapiens_hsa005620.28656792
173Tyrosine metabolism_Homo sapiens_hsa003500.28238961
174Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27912883
175Dorso-ventral axis formation_Homo sapiens_hsa043200.27568307
176Ether lipid metabolism_Homo sapiens_hsa005650.27081936
177Ovarian steroidogenesis_Homo sapiens_hsa049130.26585985
178Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24639858
179* Alcoholism_Homo sapiens_hsa050340.24626412
1802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24565218
181Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24384052
182Phospholipase D signaling pathway_Homo sapiens_hsa040720.22796006
183Glycerophospholipid metabolism_Homo sapiens_hsa005640.21988106
184Choline metabolism in cancer_Homo sapiens_hsa052310.21889804
185Metabolic pathways_Homo sapiens_hsa011000.20054688
186Sphingolipid metabolism_Homo sapiens_hsa006000.19786980
187Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19683458

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