ARAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01760800
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01760800
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.01760800
4modulation by symbiont of host immune response (GO:0052553)5.01760800
5positive regulation by symbiont of host defense response (GO:0052509)5.01760800
6modulation by symbiont of host defense response (GO:0052031)5.01760800
7positive regulation of gamma-delta T cell activation (GO:0046645)4.96722320
8detection of other organism (GO:0098543)4.74736042
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.71944044
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71944044
11detection of bacterium (GO:0016045)4.53076065
12antigen processing and presentation of endogenous antigen (GO:0019883)4.50649574
13regulation of interferon-beta biosynthetic process (GO:0045357)4.50320315
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43097265
15detection of external biotic stimulus (GO:0098581)4.17557957
16macrophage activation involved in immune response (GO:0002281)3.98216626
17positive regulation of B cell differentiation (GO:0045579)3.95180284
18immunoglobulin mediated immune response (GO:0016064)3.85925500
19neutrophil activation involved in immune response (GO:0002283)3.75339073
20regulation of gamma-delta T cell activation (GO:0046643)3.71955341
21detection of biotic stimulus (GO:0009595)3.67997725
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66388630
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.66182418
24regulation of gamma-delta T cell differentiation (GO:0045586)3.61926939
25positive regulation of interferon-alpha production (GO:0032727)3.61397036
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59754501
27regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51304003
28response to peptidoglycan (GO:0032494)3.48394952
29response to muramyl dipeptide (GO:0032495)3.46147581
30regulation of B cell receptor signaling pathway (GO:0050855)3.44589951
31regulation of leukocyte degranulation (GO:0043300)3.44507830
32regulation of interferon-alpha production (GO:0032647)3.44212810
33negative regulation of leukocyte mediated immunity (GO:0002704)3.39680913
34apoptotic cell clearance (GO:0043277)3.34951977
35regulation of mast cell activation involved in immune response (GO:0033006)3.34945259
36regulation of cholesterol storage (GO:0010885)3.32013341
37leukocyte migration involved in inflammatory response (GO:0002523)3.29911902
38germinal center formation (GO:0002467)3.26605010
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23076400
40response to host immune response (GO:0052572)3.23076400
41positive regulation of antigen processing and presentation (GO:0002579)3.18689456
42negative regulation of T cell mediated immunity (GO:0002710)3.16689493
43mannose metabolic process (GO:0006013)3.16604271
44positive regulation of mast cell activation (GO:0033005)3.16221384
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14238167
46regulation of B cell differentiation (GO:0045577)3.12404555
47response to host defenses (GO:0052200)3.07358075
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07358075
49response to host (GO:0075136)3.07358075
50B cell receptor signaling pathway (GO:0050853)3.07271562
51antigen processing and presentation via MHC class Ib (GO:0002475)3.06715449
52response to interleukin-15 (GO:0070672)3.05873030
53regulation of T-helper 2 cell differentiation (GO:0045628)3.01600816
54regulation of tolerance induction (GO:0002643)3.00906430
55production of molecular mediator involved in inflammatory response (GO:0002532)3.00797076
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00721610
57pinocytosis (GO:0006907)3.00298797
58respiratory burst (GO:0045730)2.99588073
59regulation of mast cell activation (GO:0033003)2.99464001
60regulation of T cell tolerance induction (GO:0002664)2.99155772
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89762867
62regulation of regulated secretory pathway (GO:1903305)2.88396553
63negative thymic T cell selection (GO:0045060)2.87859355
64negative regulation of interleukin-12 production (GO:0032695)2.87528694
65I-kappaB phosphorylation (GO:0007252)2.86956128
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84556711
67positive regulation of mast cell degranulation (GO:0043306)2.82226153
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.82226153
69regulation of interleukin-12 biosynthetic process (GO:0045075)2.81647829
70negative regulation of innate immune response (GO:0045824)2.81486108
71NIK/NF-kappaB signaling (GO:0038061)2.80207044
72positive regulation of cellular amide metabolic process (GO:0034250)2.78376219
73positive thymic T cell selection (GO:0045059)2.78235114
74negative regulation of granulocyte differentiation (GO:0030853)2.78211042
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78079255
76negative regulation of cell killing (GO:0031342)2.78079255
77B cell mediated immunity (GO:0019724)2.77899967
78neutrophil activation (GO:0042119)2.77676355
79response to laminar fluid shear stress (GO:0034616)2.77373927
80myeloid cell activation involved in immune response (GO:0002275)2.76756486
81low-density lipoprotein particle clearance (GO:0034383)2.76738655
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75636786
83leukocyte degranulation (GO:0043299)2.73870349
84granulocyte activation (GO:0036230)2.73344643
85negative regulation of lipid storage (GO:0010888)2.73186555
86negative T cell selection (GO:0043383)2.72404480
87regulation of interleukin-8 biosynthetic process (GO:0045414)2.70330242
88detection of molecule of bacterial origin (GO:0032490)2.68323692
89response to type I interferon (GO:0034340)2.67806630
90positive regulation of cholesterol efflux (GO:0010875)2.67712459
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67296040
92T cell selection (GO:0045058)2.66082605
93defense response to protozoan (GO:0042832)2.65812040
94T-helper 1 type immune response (GO:0042088)2.65807643
95myeloid leukocyte activation (GO:0002274)2.65610471
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65060957
97neutrophil chemotaxis (GO:0030593)2.63296428
98positive regulation of interferon-beta production (GO:0032728)2.62488463
99type I interferon signaling pathway (GO:0060337)2.62161351
100cellular response to type I interferon (GO:0071357)2.62161351
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62031764
102positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61334009
103macrophage activation (GO:0042116)2.60739497
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59731038
105regulation of antigen processing and presentation (GO:0002577)2.59714554
106regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59702780
107positive regulation of histone deacetylation (GO:0031065)2.58289501
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58204231
109positive regulation of sterol transport (GO:0032373)2.57144792
110positive regulation of cholesterol transport (GO:0032376)2.57144792
111microglial cell activation (GO:0001774)2.57055664
112phospholipid homeostasis (GO:0055091)2.55819198
113negative regulation of interleukin-6 production (GO:0032715)2.53106359
114regulation of mast cell degranulation (GO:0043304)2.52956180
115neutrophil mediated immunity (GO:0002446)2.52583946
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50378320
117cellular extravasation (GO:0045123)2.49185729
118negative regulation of toll-like receptor signaling pathway (GO:0034122)2.48069709
119interferon-gamma-mediated signaling pathway (GO:0060333)2.46840301
120complement activation, alternative pathway (GO:0006957)2.45249030
121response to protozoan (GO:0001562)2.45231153
122positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45060272
123leukocyte aggregation (GO:0070486)2.43848808
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42370032
125natural killer cell mediated cytotoxicity (GO:0042267)2.42188217
126natural killer cell mediated immunity (GO:0002228)2.42188217
127plasma lipoprotein particle clearance (GO:0034381)2.40375832
128mature B cell differentiation (GO:0002335)2.39126385
129regulation of phagocytosis (GO:0050764)2.38573590
130negative regulation of interleukin-1 beta production (GO:0032691)2.37689963
131negative regulation of cytokine production involved in immune response (GO:0002719)2.36537220
132regulation of integrin activation (GO:0033623)2.36232094
133negative regulation of erythrocyte differentiation (GO:0045647)2.35127845
134adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.35100414
135cytokine secretion (GO:0050663)2.34643319
136B cell homeostasis (GO:0001782)2.34385546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.87654700
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.03405841
3* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26378905
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.14777888
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.12012908
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99214030
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98047526
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.97378615
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79842927
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.79811792
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67175364
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65596889
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61978913
14SCL_19346495_ChIP-Seq_HPC-7_Human2.61898321
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56990546
16* VDR_21846776_ChIP-Seq_THP-1_Human2.54219452
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46407268
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.44489505
19* RXR_22158963_ChIP-Seq_LIVER_Mouse2.41054520
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36466214
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33888149
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21621934
23MYC_22102868_ChIP-Seq_BL_Human2.21363940
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19451028
25VDR_24763502_ChIP-Seq_THP-1_Human2.10038170
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09004370
27* LXR_22158963_ChIP-Seq_LIVER_Mouse2.00479126
28MAF_26560356_Chip-Seq_TH1_Human2.00282071
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96214994
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95136916
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88680307
32* SPI1_23127762_ChIP-Seq_K562_Human1.87843041
33* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86868589
34TCF7_22412390_ChIP-Seq_EML_Mouse1.85600453
35* SPI1_23547873_ChIP-Seq_NB4_Human1.84299977
36GATA1_22025678_ChIP-Seq_K562_Human1.80915375
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75783545
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74382725
39RUNX_20019798_ChIP-Seq_JUKART_Human1.73631338
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.72646180
41MYB_26560356_Chip-Seq_TH2_Human1.68468352
42MYB_26560356_Chip-Seq_TH1_Human1.68429441
43UTX_26944678_Chip-Seq_JUKART_Human1.67377809
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66731567
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60601665
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58510112
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58241590
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57322472
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51756496
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51645354
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50672186
52PU_27001747_Chip-Seq_BMDM_Mouse1.44811748
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44769836
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.43097955
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42967245
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42333943
57* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41899737
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.39758540
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38803347
60KDM2B_26808549_Chip-Seq_DND41_Human1.38197894
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36067323
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.35970986
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34837608
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32846301
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32048416
66* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30974993
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30245181
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28679341
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28310568
70LXR_22292898_ChIP-Seq_THP-1_Human1.28126229
71RACK7_27058665_Chip-Seq_MCF-7_Human1.27635383
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.25512347
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25428185
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24589169
75* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24524083
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23756556
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21872843
78KDM2B_26808549_Chip-Seq_K562_Human1.18381526
79VDR_24787735_ChIP-Seq_THP-1_Human1.17491505
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.17297724
81MAF_26560356_Chip-Seq_TH2_Human1.17042426
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16491890
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15324473
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14137717
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12220595
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12015324
87GATA3_27048872_Chip-Seq_THYMUS_Human1.11476833
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10514397
89GATA1_19941826_ChIP-Seq_K562_Human1.10021438
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08965302
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07869451
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07690051
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07248518
94CLOCK_20551151_ChIP-Seq_293T_Human1.06433876
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06255199
96BCOR_27268052_Chip-Seq_Bcells_Human1.06173883
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04881277
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04344310
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04221712
100BCL6_27268052_Chip-Seq_Bcells_Human1.04186363
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03325310
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.02341140
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00633297
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99866004
105GATA2_19941826_ChIP-Seq_K562_Human0.99547613
106* NCOR1_26117541_ChIP-Seq_K562_Human0.99449978
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98189439
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97091085
109* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96714092
110* SA1_27219007_Chip-Seq_ERYTHROID_Human0.96357447
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.96028734
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94992317
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.93714416
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92607989
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92492532
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91261915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.23843053
2MP0003303_peritoneal_inflammation2.95973166
3MP0005058_abnormal_lysosome_morphology2.92849167
4MP0003436_decreased_susceptibility_to2.68398462
5MP0000685_abnormal_immune_system2.65935019
6MP0009840_abnormal_foam_cell2.54764697
7MP0000569_abnormal_digit_pigmentation2.54011615
8MP0003191_abnormal_cellular_cholesterol2.53637415
9MP0005387_immune_system_phenotype2.48323725
10MP0001790_abnormal_immune_system2.48323725
11MP0009278_abnormal_bone_marrow2.40385033
12MP0008260_abnormal_autophagy2.39745823
13MP0001800_abnormal_humoral_immune2.36392416
14MP0002419_abnormal_innate_immunity2.36284783
15MP0003300_gastrointestinal_ulcer2.34190377
16MP0005464_abnormal_platelet_physiology2.25367848
17MP0003172_abnormal_lysosome_physiology2.24493658
18MP0002139_abnormal_hepatobiliary_system2.23667968
19MP0002452_abnormal_antigen_presenting2.16451837
20MP0005025_abnormal_response_to2.14747212
21MP0005451_abnormal_body_composition2.14614419
22MP0005000_abnormal_immune_tolerance2.10882384
23MP0009785_altered_susceptibility_to2.05053042
24MP0002723_abnormal_immune_serum1.98302112
25MP0006082_CNS_inflammation1.88243157
26MP0004947_skin_inflammation1.88198196
27MP0003828_pulmonary_edema1.80381331
28MP0002420_abnormal_adaptive_immunity1.79341186
29MP0001819_abnormal_immune_cell1.78860998
30MP0002166_altered_tumor_susceptibility1.73488565
31MP0008438_abnormal_cutaneous_collagen1.73355910
32MP0005671_abnormal_response_to1.70628319
33MP0004510_myositis1.68945724
34MP0002148_abnormal_hypersensitivity_rea1.65278012
35MP0005360_urolithiasis1.60632297
36MP0003724_increased_susceptibility_to1.59315881
37MP0001845_abnormal_inflammatory_respons1.53861699
38MP0002405_respiratory_system_inflammati1.53201087
39MP0001533_abnormal_skeleton_physiology1.52518554
40MP0001853_heart_inflammation1.52377545
41MP0005365_abnormal_bile_salt1.51415040
42MP0003705_abnormal_hypodermis_morpholog1.48057718
43MP0008469_abnormal_protein_level1.47614815
44MP0005174_abnormal_tail_pigmentation1.47220397
45MP0005397_hematopoietic_system_phenotyp1.46525321
46MP0001545_abnormal_hematopoietic_system1.46525321
47MP0010155_abnormal_intestine_physiology1.46110816
48MP0002396_abnormal_hematopoietic_system1.44674305
49MP0002398_abnormal_bone_marrow1.44370664
50MP0000716_abnormal_immune_system1.43619256
51MP0001958_emphysema1.42932110
52MP0000689_abnormal_spleen_morphology1.42394009
53MP0003566_abnormal_cell_adhesion1.41410144
54MP0003690_abnormal_glial_cell1.40877363
55MP0004883_abnormal_blood_vessel1.40850735
56MP0003183_abnormal_peptide_metabolism1.40576791
57MP0002132_abnormal_respiratory_system1.40243303
58MP0005083_abnormal_biliary_tract1.39300912
59MP0000465_gastrointestinal_hemorrhage1.39103778
60MP0001873_stomach_inflammation1.31698772
61MP0004381_abnormal_hair_follicle1.30629728
62MP0000604_amyloidosis1.28137195
63MP0002006_tumorigenesis1.22936242
64MP0002722_abnormal_immune_system1.22516823
65MP0003448_altered_tumor_morphology1.21660027
66MP0002429_abnormal_blood_cell1.20996202
67MP0000609_abnormal_liver_physiology1.18985031
68MP0003252_abnormal_bile_duct1.17609563
69MP0002933_joint_inflammation1.17458865
70MP0005164_abnormal_response_to1.15558599
71MP0005076_abnormal_cell_differentiation1.10430045
72MP0009764_decreased_sensitivity_to1.09352074
73MP0004808_abnormal_hematopoietic_stem1.08736302
74MP0000343_altered_response_to1.08693147
75MP0009333_abnormal_splenocyte_physiolog1.08659180
76MP0005023_abnormal_wound_healing1.08552503
77MP0010329_abnormal_lipoprotein_level1.08117675
78MP0002254_reproductive_system_inflammat1.08057054
79MP0002998_abnormal_bone_remodeling1.05845844
80MP0009763_increased_sensitivity_to1.03251744
81MP0008004_abnormal_stomach_pH1.02251776
82MP0003075_altered_response_to1.01467217
83MP0010307_abnormal_tumor_latency0.99910468
84MP0000371_diluted_coat_color0.99457727
85MP0003279_aneurysm0.97854595
86MP0000858_altered_metastatic_potential0.96801606
87MP0003763_abnormal_thymus_physiology0.94444420
88MP0002138_abnormal_hepatobiliary_system0.93523692
89MP0001851_eye_inflammation0.93269827
90MP0003656_abnormal_erythrocyte_physiolo0.93028307
91MP0005390_skeleton_phenotype0.91665295
92MP0005085_abnormal_gallbladder_physiolo0.91207307
93MP0000249_abnormal_blood_vessel0.87210347
94MP0003329_amyloid_beta_deposits0.86351128
95MP0000598_abnormal_liver_morphology0.85458442
96MP0005257_abnormal_intraocular_pressure0.83963787
97MP0000767_abnormal_smooth_muscle0.83300004
98MP0005319_abnormal_enzyme/_coenzyme0.83265563
99MP0010352_gastrointestinal_tract_polyps0.82939911
100MP0008875_abnormal_xenobiotic_pharmacok0.82530402
101MP0003866_abnormal_defecation0.81782485
102MP0005310_abnormal_salivary_gland0.81398648
103MP0003453_abnormal_keratinocyte_physiol0.81170647
104MP0002928_abnormal_bile_duct0.80233913
105MP0002060_abnormal_skin_morphology0.79909576
106MP0001849_ear_inflammation0.78878697
107MP0000703_abnormal_thymus_morphology0.78746525
108MP0000015_abnormal_ear_pigmentation0.78489257
109MP0003795_abnormal_bone_structure0.77749624
110MP0005075_abnormal_melanosome_morpholog0.77329835
111MP0003045_fibrosis0.77286092
112MP0003091_abnormal_cell_migration0.77268288
113MP0005166_decreased_susceptibility_to0.76219385
114MP0002136_abnormal_kidney_physiology0.74816620
115MP0001663_abnormal_digestive_system0.74742191
116MP0002277_abnormal_respiratory_mucosa0.69800322
117MP0004858_abnormal_nervous_system0.68525092
118MP0002877_abnormal_melanocyte_morpholog0.68074383
119MP0000490_abnormal_crypts_of0.66071568
120MP0008874_decreased_physiological_sensi0.64821327
121MP0000920_abnormal_myelination0.61452109
122MP0005388_respiratory_system_phenotype0.57293930
123MP0002133_abnormal_respiratory_system0.57293930
124MP0009765_abnormal_xenobiotic_induced0.57011682
125MP0003806_abnormal_nucleotide_metabolis0.56590213

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.08685312
2Recurrent bacterial skin infections (HP:0005406)4.90305439
3Eczematoid dermatitis (HP:0000976)4.58918839
4Recurrent gram-negative bacterial infections (HP:0005420)4.24715283
5Systemic lupus erythematosus (HP:0002725)4.04826365
6Vacuolated lymphocytes (HP:0001922)3.51795127
7Gastrointestinal infarctions (HP:0005244)3.51384148
8Elevated erythrocyte sedimentation rate (HP:0003565)3.44983504
9Increased cerebral lipofuscin (HP:0011813)3.41838334
10Abnormality of macrophages (HP:0004311)3.36471688
11Recurrent skin infections (HP:0001581)3.22504094
12Autoimmune thrombocytopenia (HP:0001973)3.18617074
13Periodontitis (HP:0000704)3.14778428
14Gingivitis (HP:0000230)3.13044862
15Cellulitis (HP:0100658)3.11433829
16Glomerulonephritis (HP:0000099)3.10240463
17Complement deficiency (HP:0004431)3.07257860
18Myocardial infarction (HP:0001658)3.05584319
19Mediastinal lymphadenopathy (HP:0100721)3.04470082
20Recurrent fungal infections (HP:0002841)3.00703679
21Dysostosis multiplex (HP:0000943)3.00404169
22Gingival bleeding (HP:0000225)2.97939971
23Hematochezia (HP:0002573)2.93385120
24Keratoconjunctivitis sicca (HP:0001097)2.93178535
25Myositis (HP:0100614)2.92155220
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.88353907
27Colitis (HP:0002583)2.88295165
28Recurrent viral infections (HP:0004429)2.87220613
29Spontaneous hematomas (HP:0007420)2.86478662
30Pustule (HP:0200039)2.80086441
31Encephalitis (HP:0002383)2.77220143
32Axonal loss (HP:0003447)2.75493472
33Chronic otitis media (HP:0000389)2.73175600
34Inflammation of the large intestine (HP:0002037)2.67532871
35Stomatitis (HP:0010280)2.66697916
36Abnormality of complement system (HP:0005339)2.66654626
37Mucopolysacchariduria (HP:0008155)2.66642616
38Urinary glycosaminoglycan excretion (HP:0003541)2.66642616
39Chest pain (HP:0100749)2.64311701
40Joint hemorrhage (HP:0005261)2.62563602
41Keratoconjunctivitis (HP:0001096)2.62514580
42Gastrointestinal inflammation (HP:0004386)2.60996461
43Cerebral aneurysm (HP:0004944)2.59959220
44Hemoptysis (HP:0002105)2.58267685
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58244746
46Abnormality of polysaccharide metabolism (HP:0011012)2.58244746
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58244746
48Amyloidosis (HP:0011034)2.53795763
49T lymphocytopenia (HP:0005403)2.53002031
50Vasculitis (HP:0002633)2.52341794
51Interstitial pulmonary disease (HP:0006530)2.50265684
52Nephritis (HP:0000123)2.45560291
53Deep venous thrombosis (HP:0002625)2.44940706
54Osteomyelitis (HP:0002754)2.42351615
55Purpura (HP:0000979)2.40595990
56Epistaxis (HP:0000421)2.40498960
57Prolonged bleeding time (HP:0003010)2.40101855
58Meningitis (HP:0001287)2.39551936
59Orchitis (HP:0100796)2.36416260
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36391695
61Abnormality of the nasal mucosa (HP:0000433)2.35748469
62Mitral stenosis (HP:0001718)2.35218336
63Abnormality of T cell number (HP:0011839)2.34619249
64Nasal polyposis (HP:0100582)2.33797082
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.32094569
66Episodic fever (HP:0001954)2.31696568
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.29630095
68Osteolytic defects of the hand bones (HP:0009699)2.29630095
69Impaired platelet aggregation (HP:0003540)2.28879029
70Abnormal platelet function (HP:0011869)2.28879029
71Thoracic kyphosis (HP:0002942)2.27426393
72Urticaria (HP:0001025)2.25985844
73Xanthomatosis (HP:0000991)2.25540360
74Loss of speech (HP:0002371)2.25180883
75Pulmonary embolism (HP:0002204)2.24725912
76Abnormality of glycolipid metabolism (HP:0010969)2.23500516
77Abnormality of liposaccharide metabolism (HP:0010968)2.23500516
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.23500516
79Emphysema (HP:0002097)2.18014423
80Obstructive lung disease (HP:0006536)2.16723553
81Chronic obstructive pulmonary disease (HP:0006510)2.16723553
82IgM deficiency (HP:0002850)2.15203968
83Arterial thrombosis (HP:0004420)2.12152359
84Slow saccadic eye movements (HP:0000514)2.11467223
85Menorrhagia (HP:0000132)2.11041816
86Recurrent bronchitis (HP:0002837)2.09418393
87Recurrent cutaneous fungal infections (HP:0011370)2.09223228
88Chronic mucocutaneous candidiasis (HP:0002728)2.09223228
89Premature loss of primary teeth (HP:0006323)2.09019822
90Gastrointestinal stroma tumor (HP:0100723)2.08628642
91Agammaglobulinemia (HP:0004432)2.08141400
92Hypochromic anemia (HP:0001931)2.07256523
93Leukocytosis (HP:0001974)2.07192375
94Anorexia (HP:0002039)2.05828295
95Abnormality of the peritoneum (HP:0002585)2.03710337
96Hepatosplenomegaly (HP:0001433)2.03484239
97Abnormality of the common coagulation pathway (HP:0010990)2.03109444
98Panhypogammaglobulinemia (HP:0003139)2.02753402
99Granulocytopenia (HP:0001913)1.99864381
100Abnormality of the fingertips (HP:0001211)1.98226236
101Segmental peripheral demyelination/remyelination (HP:0003481)1.98084359
102Abnormality of the thoracic spine (HP:0100711)1.97948168
103Malnutrition (HP:0004395)1.97558822
104Sepsis (HP:0100806)1.96861434
105Abnormality of T cells (HP:0002843)1.96568069
106Vertebral compression fractures (HP:0002953)1.95377445
107Peritonitis (HP:0002586)1.93920054
108Aortic aneurysm (HP:0004942)1.93101234
109Hypergammaglobulinemia (HP:0010702)1.92338615
110Restrictive lung disease (HP:0002091)1.92007735
111Increased IgE level (HP:0003212)1.91967382
112Polycythemia (HP:0001901)1.89819966
113Viral hepatitis (HP:0006562)1.89699661
114Lymphopenia (HP:0001888)1.89618098
115Pathologic fracture (HP:0002756)1.89535300
116Skin ulcer (HP:0200042)1.89356518
117Hypochromic microcytic anemia (HP:0004840)1.88949858
118Abnormality of iron homeostasis (HP:0011031)1.86584745
119Increased IgM level (HP:0003496)1.85839345
120Increased CSF protein (HP:0002922)1.85633276
121Glomerulopathy (HP:0100820)1.85195779
122Pulmonary infiltrates (HP:0002113)1.84395715
123Spondylolisthesis (HP:0003302)1.83519448
124Disinhibition (HP:0000734)1.83500249
125Thick nail (HP:0001805)1.83084663
126Abnormality of the endocardium (HP:0004306)1.81778840
127Increased serum ferritin (HP:0003281)1.81522257
128Abnormality of the pleura (HP:0002103)1.81472976
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81263256
130Abnormal platelet volume (HP:0011876)1.80056474
131Optic neuritis (HP:0100653)1.79767824
132Retrobulbar optic neuritis (HP:0100654)1.79767824
133Ulnar bowing (HP:0003031)1.78861327
134Petechiae (HP:0000967)1.78563731
135Thrombocytosis (HP:0001894)1.77856933
136Esophageal varix (HP:0002040)1.76754007
137Bruising susceptibility (HP:0000978)1.76370627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.55431104
2MAP4K13.53912363
3PRPF4B2.83971918
4IRAK32.78125038
5TYK22.71873110
6TRIB32.69038752
7KIT2.50366017
8TBK12.43934005
9BLK2.34189412
10TAOK32.31892932
11MAP3K142.25525043
12TGFBR22.12190887
13IRAK42.03617431
14CSF1R2.02442175
15PKN22.00042577
16EPHB11.93846933
17MAP3K101.93531053
18RIPK41.93135724
19JAK31.90895332
20IKBKE1.82428111
21EEF2K1.76192121
22JAK11.75091281
23TAOK11.71099398
24ZAP701.69709445
25TTN1.64486400
26BTK1.61768684
27MAP2K31.61277318
28IKBKB1.59289154
29FGFR41.55934080
30STK101.53244002
31CSK1.52535374
32CAMK1D1.49745378
33SMG11.41317967
34CDK121.40303651
35MAP3K131.38482333
36HCK1.37256843
37FLT31.36573481
38SIK11.35588253
39LRRK21.24658484
40MARK21.23589428
41SYK1.21838554
42GRK61.18633286
43FES1.18389007
44KSR21.17377458
45CDC42BPA1.16436936
46CAMK1G1.14628498
47TAOK21.10152696
48LCK1.08593343
49SIK21.08532025
50JAK21.07771972
51SIK31.06548695
52RIPK11.04912059
53CHUK1.04745593
54PRKD21.00404588
55TXK0.98636283
56* PTK60.98612775
57NEK90.97268349
58TEC0.94645180
59ITK0.93350291
60LYN0.92417019
61RPS6KA40.90001740
62IRAK20.87920518
63YES10.87075612
64PIM10.86444600
65FGFR30.86329128
66MATK0.86114852
67MAP3K60.84952087
68EPHA30.84137143
69MAP3K30.83701638
70IRAK10.81343496
71ICK0.75402563
72CDK60.75144106
73MARK30.74266358
74PAK40.73465864
75TRPM70.70846055
76MAPK70.69994233
77MAP3K70.68604334
78FGR0.65970207
79BMPR20.63511007
80MAP3K20.63006787
81SCYL20.62160115
82SGK30.61894454
83CLK10.61384119
84TESK20.60415665
85FYN0.58807868
86EGFR0.57000597
87BMX0.56752974
88STK40.56387695
89PIK3CG0.55460969
90HIPK20.54981191
91RET0.54114173
92ABL10.51245876
93PDGFRB0.50977031
94MAPK110.49692351
95PRKCH0.49439824
96MTOR0.49221723
97RPS6KA60.48700682
98CDK40.48086055
99PDK10.45672202
100PTK2B0.45462439
101STK380.45449379
102KDR0.44623427
103MAP3K50.43113565
104PRKAA20.41231663
105NME20.39942501
106RPS6KC10.39833277
107RPS6KL10.39833277
108MAPKAPK20.38992656
109MAPK150.38755368
110CAMKK10.38139736
111PDGFRA0.37844847
112PDPK10.37815962
113MAP2K20.37640824
114MAP3K80.37545135
115PRKG20.37191896
116PAK20.37052151
117MAP2K60.36897701
118GRK70.36744162
119NEK20.35252930
120MAPK120.34332021
121MAPK40.34310774
122RPS6KA20.33573891
123MAP3K110.33551019
124PIM20.33320294
125PTK20.33085348
126DYRK1B0.32679995
127MAP3K10.32574973
128TNK20.32413928

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.42966753
2Leishmaniasis_Homo sapiens_hsa051402.58297208
3B cell receptor signaling pathway_Homo sapiens_hsa046622.52726636
4Caffeine metabolism_Homo sapiens_hsa002322.49179603
5Osteoclast differentiation_Homo sapiens_hsa043802.28530205
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.15691420
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.14805926
8Complement and coagulation cascades_Homo sapiens_hsa046102.10064363
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98139537
10Other glycan degradation_Homo sapiens_hsa005111.90545607
11Lysosome_Homo sapiens_hsa041421.87442277
12Autoimmune thyroid disease_Homo sapiens_hsa053201.84151952
13Pertussis_Homo sapiens_hsa051331.83575840
14Malaria_Homo sapiens_hsa051441.70467098
15Tuberculosis_Homo sapiens_hsa051521.60741620
16Measles_Homo sapiens_hsa051621.60070605
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55640033
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52134543
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.51996415
20Primary immunodeficiency_Homo sapiens_hsa053401.51903114
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48138004
22Toxoplasmosis_Homo sapiens_hsa051451.47830568
23Hematopoietic cell lineage_Homo sapiens_hsa046401.42732391
24Legionellosis_Homo sapiens_hsa051341.41120572
25Type I diabetes mellitus_Homo sapiens_hsa049401.40351830
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38362571
27Influenza A_Homo sapiens_hsa051641.37388580
28Antigen processing and presentation_Homo sapiens_hsa046121.34799754
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29631676
30TNF signaling pathway_Homo sapiens_hsa046681.28147351
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27936005
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26738394
33Apoptosis_Homo sapiens_hsa042101.25567387
34Nitrogen metabolism_Homo sapiens_hsa009101.20944907
35Acute myeloid leukemia_Homo sapiens_hsa052211.20734929
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19740215
37Chronic myeloid leukemia_Homo sapiens_hsa052201.17853061
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.17171232
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17071686
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.16496695
41ABC transporters_Homo sapiens_hsa020101.16155260
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.14591346
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08306178
44Hepatitis C_Homo sapiens_hsa051601.04882337
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04579465
46Lysine degradation_Homo sapiens_hsa003101.03737927
47Herpes simplex infection_Homo sapiens_hsa051681.03108190
48Insulin resistance_Homo sapiens_hsa049311.00696398
49Shigellosis_Homo sapiens_hsa051310.99087411
50Chemokine signaling pathway_Homo sapiens_hsa040620.96775097
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96631269
52Hepatitis B_Homo sapiens_hsa051610.94617120
53PPAR signaling pathway_Homo sapiens_hsa033200.92952230
54Platelet activation_Homo sapiens_hsa046110.92839476
55Renal cell carcinoma_Homo sapiens_hsa052110.90999934
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90470374
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89173297
58T cell receptor signaling pathway_Homo sapiens_hsa046600.88975219
59Amoebiasis_Homo sapiens_hsa051460.88291081
60Tryptophan metabolism_Homo sapiens_hsa003800.86397490
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84242530
62Arginine biosynthesis_Homo sapiens_hsa002200.82791079
63Selenocompound metabolism_Homo sapiens_hsa004500.82127378
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.80287081
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.79872378
66Pancreatic cancer_Homo sapiens_hsa052120.79753978
67Small cell lung cancer_Homo sapiens_hsa052220.79531201
68Fatty acid degradation_Homo sapiens_hsa000710.76730676
69Histidine metabolism_Homo sapiens_hsa003400.74819547
70Phagosome_Homo sapiens_hsa041450.74651593
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.74453589
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73814088
73GnRH signaling pathway_Homo sapiens_hsa049120.73625919
74Salmonella infection_Homo sapiens_hsa051320.73374055
75Starch and sucrose metabolism_Homo sapiens_hsa005000.72716356
76Endometrial cancer_Homo sapiens_hsa052130.71612052
77* Endocytosis_Homo sapiens_hsa041440.70920110
78Notch signaling pathway_Homo sapiens_hsa043300.70623408
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68948953
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68177813
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.66040679
82African trypanosomiasis_Homo sapiens_hsa051430.64323215
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.64287927
84HIF-1 signaling pathway_Homo sapiens_hsa040660.63423370
85Choline metabolism in cancer_Homo sapiens_hsa052310.63248897
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62757060
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62694681
88Allograft rejection_Homo sapiens_hsa053300.62477997
89Sulfur relay system_Homo sapiens_hsa041220.60503616
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60483519
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60209190
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59904499
93Bladder cancer_Homo sapiens_hsa052190.59735865
94FoxO signaling pathway_Homo sapiens_hsa040680.59200822
95Epstein-Barr virus infection_Homo sapiens_hsa051690.58334376
96Prolactin signaling pathway_Homo sapiens_hsa049170.58131060
97HTLV-I infection_Homo sapiens_hsa051660.57713468
98Folate biosynthesis_Homo sapiens_hsa007900.56888534
99Rheumatoid arthritis_Homo sapiens_hsa053230.55943085
100Inositol phosphate metabolism_Homo sapiens_hsa005620.55697420
101Viral myocarditis_Homo sapiens_hsa054160.54926089
102Graft-versus-host disease_Homo sapiens_hsa053320.53195932
103Dorso-ventral axis formation_Homo sapiens_hsa043200.53096066
104Peroxisome_Homo sapiens_hsa041460.52972943
105Proteoglycans in cancer_Homo sapiens_hsa052050.51289422
106Type II diabetes mellitus_Homo sapiens_hsa049300.51052845
107Colorectal cancer_Homo sapiens_hsa052100.48099233
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48020716
109Estrogen signaling pathway_Homo sapiens_hsa049150.46737258
110Rap1 signaling pathway_Homo sapiens_hsa040150.46567386
111Insulin signaling pathway_Homo sapiens_hsa049100.46482561
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46473172
113Non-small cell lung cancer_Homo sapiens_hsa052230.46414691
114ErbB signaling pathway_Homo sapiens_hsa040120.46057457
115Focal adhesion_Homo sapiens_hsa045100.45983720
116Asthma_Homo sapiens_hsa053100.44835480
117mTOR signaling pathway_Homo sapiens_hsa041500.44087187
118beta-Alanine metabolism_Homo sapiens_hsa004100.43747305
119Prostate cancer_Homo sapiens_hsa052150.42623998
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.42221497
121Chemical carcinogenesis_Homo sapiens_hsa052040.41737757
122MAPK signaling pathway_Homo sapiens_hsa040100.41538431
123Renin-angiotensin system_Homo sapiens_hsa046140.40487241
124Viral carcinogenesis_Homo sapiens_hsa052030.39588338
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37944470
126Prion diseases_Homo sapiens_hsa050200.37619430
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36664741
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36402794
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35118306
130VEGF signaling pathway_Homo sapiens_hsa043700.33148713

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