ARAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.34485372
2axon ensheathment in central nervous system (GO:0032291)7.34485372
3positive regulation of gamma-delta T cell activation (GO:0046645)5.68839958
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.26623745
5negative regulation of cell killing (GO:0031342)5.26623745
6fatty acid elongation (GO:0030497)4.86764329
7myelination (GO:0042552)4.81539461
8ensheathment of neurons (GO:0007272)4.79848069
9axon ensheathment (GO:0008366)4.79848069
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66851870
11regulation of B cell receptor signaling pathway (GO:0050855)4.62590782
12long-chain fatty acid biosynthetic process (GO:0042759)4.43323257
13negative regulation of neurotransmitter secretion (GO:0046929)4.40938720
14presynaptic membrane assembly (GO:0097105)4.37431404
15negative regulation of T cell mediated immunity (GO:0002710)4.34623318
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31690162
17regulation of gamma-delta T cell activation (GO:0046643)4.29276736
18L-amino acid import (GO:0043092)4.21692876
19presynaptic membrane organization (GO:0097090)4.13909003
20regulation of gamma-delta T cell differentiation (GO:0045586)4.12484412
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07038639
22negative regulation of neurotransmitter transport (GO:0051589)4.01922915
23positive T cell selection (GO:0043368)4.00251696
24response to interleukin-15 (GO:0070672)3.94997666
25cellular response to interleukin-15 (GO:0071350)3.93533344
26antigen processing and presentation of endogenous antigen (GO:0019883)3.86410614
27T cell migration (GO:0072678)3.85663513
28positive thymic T cell selection (GO:0045059)3.82306561
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82241391
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.54995966
31negative regulation of interleukin-12 production (GO:0032695)3.54149719
32T cell selection (GO:0045058)3.54073984
33macrophage activation involved in immune response (GO:0002281)3.43937936
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.43859177
35oligodendrocyte differentiation (GO:0048709)3.43627298
36type I interferon signaling pathway (GO:0060337)3.43264097
37cellular response to type I interferon (GO:0071357)3.43264097
38regulation of memory T cell differentiation (GO:0043380)3.42256440
39B cell receptor signaling pathway (GO:0050853)3.41478527
40response to type I interferon (GO:0034340)3.41240202
41leukocyte aggregation (GO:0070486)3.39656713
42neuronal action potential propagation (GO:0019227)3.38719121
43thymic T cell selection (GO:0045061)3.36913183
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36060629
45detection of other organism (GO:0098543)3.34554268
46regulation of isotype switching to IgG isotypes (GO:0048302)3.33744585
47regulation of alpha-beta T cell proliferation (GO:0046640)3.28861461
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28050034
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28050034
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.28050034
51modulation by symbiont of host immune response (GO:0052553)3.28050034
52positive regulation by symbiont of host defense response (GO:0052509)3.28050034
53modulation by symbiont of host defense response (GO:0052031)3.28050034
54asymmetric protein localization (GO:0008105)3.25988887
55virion attachment to host cell (GO:0019062)3.23236067
56adhesion of symbiont to host cell (GO:0044650)3.23236067
57cellular response to ethanol (GO:0071361)3.23185415
58interferon-gamma-mediated signaling pathway (GO:0060333)3.23080665
59myelin maintenance (GO:0043217)3.22350745
60CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21297457
61T-helper cell differentiation (GO:0042093)3.21297457
62cellular extravasation (GO:0045123)3.19049837
63neuron cell-cell adhesion (GO:0007158)3.18839812
64cerebral cortex radially oriented cell migration (GO:0021799)3.18509316
65positive regulation of humoral immune response (GO:0002922)3.17370646
66negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.17271146
67detection of bacterium (GO:0016045)3.16884364
68interferon-gamma production (GO:0032609)3.15895429
69cerebellar granule cell differentiation (GO:0021707)3.15166485
70positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14426022
71positive regulation of granulocyte differentiation (GO:0030854)3.12629912
72regulation of B cell differentiation (GO:0045577)3.12016970
73amino acid import (GO:0043090)3.11510408
74nerve growth factor signaling pathway (GO:0038180)3.11024538
75defense response to protozoan (GO:0042832)3.10390847
76negative regulation of leukocyte mediated immunity (GO:0002704)3.08166732
77photoreceptor cell differentiation (GO:0046530)3.07522421
78eye photoreceptor cell differentiation (GO:0001754)3.07522421
79transmission of nerve impulse (GO:0019226)3.04591308
80microglial cell activation (GO:0001774)3.01412886
81negative regulation of adaptive immune response (GO:0002820)3.00756273
82regulation of interleukin-2 biosynthetic process (GO:0045076)2.98850104
83peptidyl-tyrosine autophosphorylation (GO:0038083)2.96940451
84glycerophospholipid catabolic process (GO:0046475)2.95902961
85gamma-aminobutyric acid signaling pathway (GO:0007214)2.93692043
86apical protein localization (GO:0045176)2.92701930
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.92434764
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89672884
89response to protozoan (GO:0001562)2.89525144
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.88773388
91regulation of T cell tolerance induction (GO:0002664)2.88763938
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88356012
93positive regulation of B cell differentiation (GO:0045579)2.87282553
94tolerance induction (GO:0002507)2.87199951
95ionotropic glutamate receptor signaling pathway (GO:0035235)2.86601785
96negative regulation of T-helper cell differentiation (GO:0045623)2.84921555
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84921555
98myeloid cell activation involved in immune response (GO:0002275)2.84075473
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83663701
100CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.83426853
101phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83394641
102protein localization to endosome (GO:0036010)2.82615198
103regulation of chronic inflammatory response (GO:0002676)2.82472785
104response to muramyl dipeptide (GO:0032495)2.82451115
105T cell differentiation involved in immune response (GO:0002292)2.82429168
106alpha-beta T cell differentiation involved in immune response (GO:0002293)2.82429168
107alpha-beta T cell activation involved in immune response (GO:0002287)2.82429168
108negative regulation of protein localization to cell surface (GO:2000009)2.81784022
109membrane assembly (GO:0071709)2.80843026
110adult walking behavior (GO:0007628)2.80780897
111regulation of B cell proliferation (GO:0030888)2.80762278
112mast cell activation (GO:0045576)2.80113833
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79062662
114antigen receptor-mediated signaling pathway (GO:0050851)2.78929820
115regulation of regulatory T cell differentiation (GO:0045589)2.78324381
116germinal center formation (GO:0002467)2.77191494
117alpha-beta T cell differentiation (GO:0046632)2.77184281
118glutamate receptor signaling pathway (GO:0007215)2.76784730
119regulation of tolerance induction (GO:0002643)2.76156950
120regulation of interferon-beta biosynthetic process (GO:0045357)2.75966420
121response to peptidoglycan (GO:0032494)2.75689418
122glutamate secretion (GO:0014047)2.74847268
123regulation of activation of Janus kinase activity (GO:0010533)2.73979888
124regulation of collateral sprouting (GO:0048670)2.73699324
125detection of external biotic stimulus (GO:0098581)2.72946589
126myeloid dendritic cell activation (GO:0001773)2.72839778
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72793773
128positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72622973
129positive regulation of B cell mediated immunity (GO:0002714)2.72622973
130T cell receptor signaling pathway (GO:0050852)2.72575189
131positive regulation of B cell proliferation (GO:0030890)2.72087653
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71276091
133regulation of natural killer cell mediated immunity (GO:0002715)2.71276091
134myeloid dendritic cell differentiation (GO:0043011)2.70339233
135positive regulation of cellular amide metabolic process (GO:0034250)2.69670888
136creatine metabolic process (GO:0006600)2.68739751
137activated T cell proliferation (GO:0050798)2.68489230
138hepatocyte apoptotic process (GO:0097284)2.68349820
139regulation of T cell mediated cytotoxicity (GO:0001914)2.68041717
140positive regulation of interleukin-2 production (GO:0032743)2.66641360
141astrocyte development (GO:0014002)2.65051983
142positive regulation of interleukin-17 production (GO:0032740)2.63291237
143gamma-aminobutyric acid transport (GO:0015812)2.59542834
144Golgi to endosome transport (GO:0006895)2.58407057
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58230235
146negative regulation of axonogenesis (GO:0050771)2.56178564
147Rap protein signal transduction (GO:0032486)2.54566734
148magnesium ion transport (GO:0015693)2.54151280
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53739062
150substantia nigra development (GO:0021762)2.53215507
151myelination in peripheral nervous system (GO:0022011)2.52492142
152peripheral nervous system axon ensheathment (GO:0032292)2.52492142
153synaptic vesicle exocytosis (GO:0016079)2.51364717
154cellular potassium ion homeostasis (GO:0030007)2.51327460
155positive regulation of T-helper cell differentiation (GO:0045624)2.50455107
156positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.50254378
157L-serine transport (GO:0015825)2.49490278
158cholesterol biosynthetic process (GO:0006695)2.48366594
159serine transport (GO:0032329)2.47873431
160regulation of dendritic spine morphogenesis (GO:0061001)2.45838058
161regulation of dendritic spine development (GO:0060998)2.45800125
162import into cell (GO:0098657)2.45337420
163regulation of synaptic vesicle exocytosis (GO:2000300)2.45138834
164neuron-neuron synaptic transmission (GO:0007270)2.44389527
165synaptic vesicle maturation (GO:0016188)2.44319246
166cellular response to epinephrine stimulus (GO:0071872)2.42738648
167membrane tubulation (GO:0097320)2.41624652
168synaptic transmission, glutamatergic (GO:0035249)2.40950884
169negative regulation of inclusion body assembly (GO:0090084)2.40032062
170long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.38914394
171regulation of voltage-gated calcium channel activity (GO:1901385)2.38860193
172locomotory exploration behavior (GO:0035641)2.38277582
173dendritic spine morphogenesis (GO:0060997)2.36772673
174long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.34106040
175neuronal ion channel clustering (GO:0045161)2.33664317
176cyclic nucleotide catabolic process (GO:0009214)2.33374097
177negative T cell selection (GO:0043383)2.33331633
178peripheral nervous system development (GO:0007422)2.32368913
179regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31931516
180positive regulation of action potential (GO:0045760)2.30616752
181regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.29683156
182regulation of T-helper cell differentiation (GO:0045622)2.29374419
183response to lipoprotein particle (GO:0055094)2.29047073
184positive regulation of interleukin-4 production (GO:0032753)2.28168292
185negative regulation of synaptic transmission (GO:0050805)2.28165536
186long-term synaptic potentiation (GO:0060291)2.28010430
187response to epinephrine (GO:0071871)2.25855316
188establishment of mitochondrion localization (GO:0051654)2.25668435
189positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.25519438
190protein localization to synapse (GO:0035418)2.25012516
191negative thymic T cell selection (GO:0045060)2.24734392
192glycosphingolipid biosynthetic process (GO:0006688)2.24387050
193regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.24331962
194organ growth (GO:0035265)2.21818028
195regulation of excitatory postsynaptic membrane potential (GO:0060079)2.21122041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.35477753
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.78361005
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.72292570
4GBX2_23144817_ChIP-Seq_PC3_Human3.22699993
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.06470233
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95209870
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.69228015
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60331186
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58898565
10EZH2_22144423_ChIP-Seq_EOC_Human2.46642693
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43260375
12TAF15_26573619_Chip-Seq_HEK293_Human2.40999258
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40335642
14MYB_26560356_Chip-Seq_TH2_Human2.35532656
15SCL_19346495_ChIP-Seq_HPC-7_Human2.29341491
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28314868
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25707187
18AR_21572438_ChIP-Seq_LNCaP_Human2.23060339
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.17376063
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13514419
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11844811
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10903751
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08152559
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07762979
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06961381
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05435325
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97760883
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89428800
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84381405
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82060448
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81169254
32GATA1_22025678_ChIP-Seq_K562_Human1.80943448
33* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80794331
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80639887
35MYB_26560356_Chip-Seq_TH1_Human1.79625181
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79290294
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79290294
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78939838
39DROSHA_22980978_ChIP-Seq_HELA_Human1.77229973
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75813771
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72654949
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71390733
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66701337
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66559345
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.65524949
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.63697271
47* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60535299
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60404402
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58826304
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.56297453
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53853585
52VDR_22108803_ChIP-Seq_LS180_Human1.52815997
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.52812138
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52800615
55SPI1_23127762_ChIP-Seq_K562_Human1.51909588
56P300_19829295_ChIP-Seq_ESCs_Human1.51053962
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50678841
58MAF_26560356_Chip-Seq_TH1_Human1.49482994
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48909702
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47971004
61GATA3_26560356_Chip-Seq_TH2_Human1.46657540
62SMAD4_21799915_ChIP-Seq_A2780_Human1.46002153
63ER_23166858_ChIP-Seq_MCF-7_Human1.45362090
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45009737
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.41860755
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.39991006
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39982746
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39843888
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39432560
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38726102
71RUNX_20019798_ChIP-Seq_JUKART_Human1.38696081
72TP53_16413492_ChIP-PET_HCT116_Human1.35897417
73* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34852902
74STAT3_23295773_ChIP-Seq_U87_Human1.33743978
75* RARB_27405468_Chip-Seq_BRAIN_Mouse1.32436257
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30423546
77* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30118550
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29281735
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.28721753
80* PRDM14_20953172_ChIP-Seq_ESCs_Human1.28134499
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.27834805
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.27632855
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27021875
84AHR_22903824_ChIP-Seq_MCF-7_Human1.26162148
85* SPI1_23547873_ChIP-Seq_NB4_Human1.25700790
86RXR_22108803_ChIP-Seq_LS180_Human1.24668170
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23607891
88VDR_24763502_ChIP-Seq_THP-1_Human1.23239814
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23079775
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22014222
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21476805
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.21145578
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.16887893
94TP53_18474530_ChIP-ChIP_U2OS_Human1.16866165
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.16066891
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15414281
97* TCF4_23295773_ChIP-Seq_U87_Human1.15008496
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14629301
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12878977
100PU_27001747_Chip-Seq_BMDM_Mouse1.12466271
101* REST_21632747_ChIP-Seq_MESCs_Mouse1.12465642
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12112440
103FUS_26573619_Chip-Seq_HEK293_Human1.11384367
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10756818
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08510392
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.07836162
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07644915
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07096337
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06302204
110* AR_25329375_ChIP-Seq_VCAP_Human1.06088840
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06025727
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.05871031
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05589888
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.05479466
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.05245717
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05235163
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04405309
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04186590
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03944691
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.03667358
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03566680
122RUNX1_22412390_ChIP-Seq_EML_Mouse1.03438367
123* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03293513
124* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03293513
125IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02700674
126UTX_26944678_Chip-Seq_JUKART_Human1.01739139
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01207577
128TCF7_22412390_ChIP-Seq_EML_Mouse1.00999722
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00984544
130P53_22387025_ChIP-Seq_ESCs_Mouse1.00620311
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00497230
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99607917
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.99570665
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98809302
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98691707
136SMRT_27268052_Chip-Seq_Bcells_Human0.98278720
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97943776
138P300_18555785_Chip-Seq_ESCs_Mouse0.97716703
139CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97475352
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97183091
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97183091
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96970198
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96667851
144* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96585037
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96021081
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.95907711
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95039908
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93929965
149VDR_24787735_ChIP-Seq_THP-1_Human0.93193405
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.92395764
151* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92278291
152SOX2_18555785_Chip-Seq_ESCs_Mouse0.92241210
153GATA1_19941826_ChIP-Seq_K562_Human0.90851256
154TP63_17297297_ChIP-ChIP_HaCaT_Human0.88719991
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.88133047
156GATA2_19941826_ChIP-Seq_K562_Human0.87584503
157* MAF_26560356_Chip-Seq_TH2_Human0.86732630
158TP63_23658742_ChIP-Seq_EP156T_Human0.85355030
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83738414
160KDM2B_26808549_Chip-Seq_DND41_Human0.83676432
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82056720
162GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81448551
163FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77860078
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77014209
165CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74932252
166CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74118198
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73684584
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71748205
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71540034
170VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70854907
171MYC_22102868_ChIP-Seq_BL_Human0.68936730
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67262356
173SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67262356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.52543484
2MP0000920_abnormal_myelination4.03652170
3MP0004859_abnormal_synaptic_plasticity3.91276645
4MP0004270_analgesia3.81430871
5MP0001835_abnormal_antigen_presentation3.74011477
6MP0003303_peritoneal_inflammation3.35258075
7MP0003436_decreased_susceptibility_to3.12589304
8MP0003690_abnormal_glial_cell2.97284614
9MP0003724_increased_susceptibility_to2.94887395
10MP0001486_abnormal_startle_reflex2.75982972
11MP0009785_altered_susceptibility_to2.61325285
12MP0009046_muscle_twitch2.60852230
13MP0000569_abnormal_digit_pigmentation2.59551731
14MP0003329_amyloid_beta_deposits2.58044389
15MP0002064_seizures2.56791588
16MP0003635_abnormal_synaptic_transmissio2.55765182
17MP0003950_abnormal_plasma_membrane2.55408668
18MP0004885_abnormal_endolymph2.46103445
19MP0005025_abnormal_response_to2.42676995
20MP0004742_abnormal_vestibular_system2.41664319
21MP0009745_abnormal_behavioral_response2.40505253
22MP0002452_abnormal_antigen_presenting2.38916707
23MP0002148_abnormal_hypersensitivity_rea2.38509700
24MP0002272_abnormal_nervous_system2.38033866
25MP0002420_abnormal_adaptive_immunity2.32802646
26MP0002419_abnormal_innate_immunity2.30852857
27MP0001819_abnormal_immune_cell2.28760198
28MP0010678_abnormal_skin_adnexa2.20652881
29MP0004381_abnormal_hair_follicle2.15243353
30MP0005423_abnormal_somatic_nervous2.07833999
31MP0001485_abnormal_pinna_reflex1.99467713
32MP0005171_absent_coat_pigmentation1.99380880
33MP0000383_abnormal_hair_follicle1.97078240
34MP0002166_altered_tumor_susceptibility1.93395117
35MP0002063_abnormal_learning/memory/cond1.92874112
36MP0009333_abnormal_splenocyte_physiolog1.91134850
37MP0005451_abnormal_body_composition1.89427661
38MP0000778_abnormal_nervous_system1.88950248
39MP0002398_abnormal_bone_marrow1.86852439
40MP0010155_abnormal_intestine_physiology1.86342080
41MP0002405_respiratory_system_inflammati1.84598649
42MP0001440_abnormal_grooming_behavior1.83680940
43MP0003136_yellow_coat_color1.83510765
44MP0002572_abnormal_emotion/affect_behav1.81901808
45MP0000716_abnormal_immune_system1.81183379
46MP0002734_abnormal_mechanical_nocicepti1.75459173
47MP0001905_abnormal_dopamine_level1.68926143
48MP0000604_amyloidosis1.67776376
49MP0001346_abnormal_lacrimal_gland1.67133624
50MP0005310_abnormal_salivary_gland1.66989877
51MP0003634_abnormal_glial_cell1.66815017
52MP0005409_darkened_coat_color1.64994136
53MP0003632_abnormal_nervous_system1.63450406
54MP0008569_lethality_at_weaning1.62509597
55MP0003866_abnormal_defecation1.59970270
56MP0001873_stomach_inflammation1.59587398
57MP0001845_abnormal_inflammatory_respons1.58604468
58MP0004142_abnormal_muscle_tone1.56227233
59MP0008057_abnormal_DNA_replication1.56181845
60MP0001501_abnormal_sleep_pattern1.53116335
61MP0003183_abnormal_peptide_metabolism1.48699297
62MP0002006_tumorigenesis1.47870573
63MP0000703_abnormal_thymus_morphology1.47214559
64MP0003631_nervous_system_phenotype1.46035268
65MP0000689_abnormal_spleen_morphology1.45174934
66MP0002722_abnormal_immune_system1.42436648
67MP0002067_abnormal_sensory_capabilities1.39812538
68MP0010234_abnormal_vibrissa_follicle1.39407582
69MP0003633_abnormal_nervous_system1.38736024
70MP0003191_abnormal_cellular_cholesterol1.37672508
71MP0001348_abnormal_lacrimal_gland1.37430580
72MP0001853_heart_inflammation1.36158939
73MP0000465_gastrointestinal_hemorrhage1.34331784
74MP0005671_abnormal_response_to1.34053787
75MP0001533_abnormal_skeleton_physiology1.34022620
76MP0001529_abnormal_vocalization1.32583122
77MP0002429_abnormal_blood_cell1.31334097
78MP0005387_immune_system_phenotype1.29120107
79MP0001790_abnormal_immune_system1.29120107
80MP0001851_eye_inflammation1.28594373
81MP0002254_reproductive_system_inflammat1.28499106
82MP0005464_abnormal_platelet_physiology1.26690969
83MP0005386_behavior/neurological_phenoty1.26393437
84MP0004924_abnormal_behavior1.26393437
85MP0009764_decreased_sensitivity_to1.26144988
86MP0002138_abnormal_hepatobiliary_system1.25389883
87MP0002229_neurodegeneration1.25205325
88MP0003172_abnormal_lysosome_physiology1.24083720
89MP0000579_abnormal_nail_morphology1.21563626
90MP0005166_decreased_susceptibility_to1.17727322
91MP0001968_abnormal_touch/_nociception1.14675809
92MP0002796_impaired_skin_barrier1.13279005
93MP0008260_abnormal_autophagy1.13189849
94MP0002998_abnormal_bone_remodeling1.10266844
95MP0002882_abnormal_neuron_morphology1.09791910
96MP0000015_abnormal_ear_pigmentation1.09779310
97MP0003787_abnormal_imprinting1.09595298
98MP0000566_synostosis1.09400395
99MP0002009_preneoplasia1.09275659
100MP0002066_abnormal_motor_capabilities/c1.09266588
101MP0008469_abnormal_protein_level1.07669836
102MP0003656_abnormal_erythrocyte_physiolo1.07481412
103MP0000955_abnormal_spinal_cord1.07421509
104MP0005623_abnormal_meninges_morphology1.06962918
105MP0009278_abnormal_bone_marrow1.05002179
106MP0000647_abnormal_sebaceous_gland1.04975899
107MP0001545_abnormal_hematopoietic_system1.03977193
108MP0005397_hematopoietic_system_phenotyp1.03977193
109MP0001502_abnormal_circadian_rhythm1.03551739
110MP0001970_abnormal_pain_threshold1.02651905
111MP0004883_abnormal_blood_vessel1.02032235
112MP0002396_abnormal_hematopoietic_system0.99975428
113MP0003453_abnormal_keratinocyte_physiol0.99522820
114MP0004808_abnormal_hematopoietic_stem0.98673646
115MP0001963_abnormal_hearing_physiology0.97449029
116MP0005000_abnormal_immune_tolerance0.95266266
117MP0004510_myositis0.95253050
118MP0005410_abnormal_fertilization0.94259828
119MP0002733_abnormal_thermal_nociception0.92604915
120MP0003091_abnormal_cell_migration0.91729812
121MP0009780_abnormal_chondrocyte_physiolo0.89599010
122MP0000685_abnormal_immune_system0.89356663
123MP0000427_abnormal_hair_cycle0.89167549
124MP0003828_pulmonary_edema0.88898558
125MP0005551_abnormal_eye_electrophysiolog0.88340039
126MP0003448_altered_tumor_morphology0.87139360
127MP0008874_decreased_physiological_sensi0.85805651
128MP0006082_CNS_inflammation0.85049255
129MP0002332_abnormal_exercise_endurance0.84096557
130MP0002736_abnormal_nociception_after0.83813542
131MP0001661_extended_life_span0.83207910
132MP0000858_altered_metastatic_potential0.80958226
133MP0004185_abnormal_adipocyte_glucose0.80324779
134MP0008004_abnormal_stomach_pH0.80237436
135MP0002557_abnormal_social/conspecific_i0.79182974
136MP0001984_abnormal_olfaction0.77786403
137MP0005164_abnormal_response_to0.76332849
138MP0001800_abnormal_humoral_immune0.75906953
139MP0004147_increased_porphyrin_level0.75805874
140MP0005174_abnormal_tail_pigmentation0.75438207
141MP0004947_skin_inflammation0.73941210
142MP0003763_abnormal_thymus_physiology0.72593228
143MP0009763_increased_sensitivity_to0.72289787
144MP0001177_atelectasis0.72137135
145MP0002822_catalepsy0.71875644
146MP0004484_altered_response_of0.71744619
147MP0002723_abnormal_immune_serum0.71528120
148MP0003075_altered_response_to0.71372919
149MP0005167_abnormal_blood-brain_barrier0.70402714
150MP0000462_abnormal_digestive_system0.67958794
151MP0002152_abnormal_brain_morphology0.67894069
152MP0003300_gastrointestinal_ulcer0.67720291
153MP0009765_abnormal_xenobiotic_induced0.67011859
154MP0002735_abnormal_chemical_nociception0.66925688
155MP0001299_abnormal_eye_distance/0.66456076
156MP0000377_abnormal_hair_follicle0.65434718
157MP0004043_abnormal_pH_regulation0.63465553
158MP0005075_abnormal_melanosome_morpholog0.63376832
159MP0002752_abnormal_somatic_nervous0.62480932
160MP0003045_fibrosis0.61815122
161MP0005646_abnormal_pituitary_gland0.61014051
162MP0000249_abnormal_blood_vessel0.60674026
163MP0002933_joint_inflammation0.60595931
164MP0001216_abnormal_epidermal_layer0.59917016
165MP0001663_abnormal_digestive_system0.59853364

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.44630002
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.44630002
3Parakeratosis (HP:0001036)5.33212423
4Neurofibrillary tangles (HP:0002185)5.28922654
5Eczematoid dermatitis (HP:0000976)4.81501157
6Sensory axonal neuropathy (HP:0003390)4.60940493
7Recurrent bacterial skin infections (HP:0005406)4.47276369
8Focal motor seizures (HP:0011153)4.33913258
9Abnormality of the corticospinal tract (HP:0002492)4.29749584
10Cerebral inclusion bodies (HP:0100314)3.99728622
11Orchitis (HP:0100796)3.91599050
12Recurrent fungal infections (HP:0002841)3.91279223
13Myositis (HP:0100614)3.85639081
14Recurrent abscess formation (HP:0002722)3.82488773
15Peripheral hypomyelination (HP:0007182)3.81869208
16Atonic seizures (HP:0010819)3.62558185
17Dysmetria (HP:0001310)3.62336638
18Recurrent viral infections (HP:0004429)3.61894044
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.61571899
20Epileptic encephalopathy (HP:0200134)3.58985152
21Autoimmune hemolytic anemia (HP:0001890)3.53140594
22Chronic mucocutaneous candidiasis (HP:0002728)3.51311794
23Recurrent cutaneous fungal infections (HP:0011370)3.51311794
24Abnormality of T cells (HP:0002843)3.50600052
25Supranuclear gaze palsy (HP:0000605)3.47994522
26Recurrent skin infections (HP:0001581)3.46215989
27Scanning speech (HP:0002168)3.44577011
28Mediastinal lymphadenopathy (HP:0100721)3.36044845
29Spastic gait (HP:0002064)3.32406504
30Elevated erythrocyte sedimentation rate (HP:0003565)3.30286303
31Myokymia (HP:0002411)3.28925587
32Intention tremor (HP:0002080)3.28380717
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.27307968
34Keratoconjunctivitis sicca (HP:0001097)3.24840102
35Meningitis (HP:0001287)3.22865256
36Onion bulb formation (HP:0003383)3.18090470
37Thickened helices (HP:0000391)3.16561752
38Abnormality of macrophages (HP:0004311)3.15997770
39Vasculitis (HP:0002633)3.07648624
40Gastrointestinal infarctions (HP:0005244)3.03365605
41Pulmonary infiltrates (HP:0002113)2.99944400
42Encephalitis (HP:0002383)2.99671074
43Panhypogammaglobulinemia (HP:0003139)2.99163231
44Recurrent bronchitis (HP:0002837)2.97592241
45Keratoconjunctivitis (HP:0001096)2.96530388
46Slow saccadic eye movements (HP:0000514)2.93851668
47Increased IgE level (HP:0003212)2.92920626
48Pustule (HP:0200039)2.92078414
49Diplopia (HP:0000651)2.86992361
50Abnormality of binocular vision (HP:0011514)2.86992361
51Insidious onset (HP:0003587)2.86012433
52Termporal pattern (HP:0011008)2.86012433
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81197210
54Colitis (HP:0002583)2.80890290
55Aplasia involving bones of the extremities (HP:0009825)2.73601913
56Aplasia involving bones of the upper limbs (HP:0009823)2.73601913
57Aplasia of the phalanges of the hand (HP:0009802)2.73601913
58Megalencephaly (HP:0001355)2.73091988
59Focal seizures (HP:0007359)2.72643457
60Clumsiness (HP:0002312)2.72309984
61Hemoptysis (HP:0002105)2.72257647
62Chronic diarrhea (HP:0002028)2.72192092
63Eosinophilia (HP:0001880)2.71921045
64Gaze-evoked nystagmus (HP:0000640)2.71464938
65Progressive cerebellar ataxia (HP:0002073)2.69211585
66Hyperventilation (HP:0002883)2.67424305
67Autoimmune thrombocytopenia (HP:0001973)2.64780649
68Leukocytosis (HP:0001974)2.61470322
69Akinesia (HP:0002304)2.60788074
70Agammaglobulinemia (HP:0004432)2.57443940
71Congenital ichthyosiform erythroderma (HP:0007431)2.57262348
72Cerebral hemorrhage (HP:0001342)2.56770919
73Broad-based gait (HP:0002136)2.53656415
74Inflammation of the large intestine (HP:0002037)2.53644286
75Recurrent gram-negative bacterial infections (HP:0005420)2.53464998
76Increased IgM level (HP:0003496)2.53292778
77Gingivitis (HP:0000230)2.53282700
78Alacrima (HP:0000522)2.50680754
79IgG deficiency (HP:0004315)2.50631697
80Abnormality of eosinophils (HP:0001879)2.49908491
81Granulocytopenia (HP:0001913)2.44755378
82Abnormality of B cell number (HP:0010975)2.44466528
83Spontaneous hematomas (HP:0007420)2.43645152
84Abnormal auditory evoked potentials (HP:0006958)2.43099108
85Pulmonary embolism (HP:0002204)2.41210856
86Severe combined immunodeficiency (HP:0004430)2.37769775
87Arterial thrombosis (HP:0004420)2.36782185
88Metabolic alkalosis (HP:0200114)2.35380761
89Gastrointestinal inflammation (HP:0004386)2.34477404
90Papilledema (HP:0001085)2.33783756
91Premature skin wrinkling (HP:0100678)2.31923421
92Thyroiditis (HP:0100646)2.31605157
93Increased circulating renin level (HP:0000848)2.31588239
94Cupped ear (HP:0000378)2.30508626
95Urinary bladder sphincter dysfunction (HP:0002839)2.30439538
96Hypoplasia of the thymus (HP:0000778)2.27777422
97Viral hepatitis (HP:0006562)2.26998151
98Chest pain (HP:0100749)2.26741570
99Action tremor (HP:0002345)2.26570957
100Dysdiadochokinesis (HP:0002075)2.26231296
101Abnormality of T cell physiology (HP:0011840)2.26186484
102Chronic otitis media (HP:0000389)2.25343931
103IgA deficiency (HP:0002720)2.22896114
104Erythroderma (HP:0001019)2.20680386
105Widely spaced teeth (HP:0000687)2.20210849
106B lymphocytopenia (HP:0010976)2.19951098
107Subacute progressive viral hepatitis (HP:0006572)2.19597408
108Joint swelling (HP:0001386)2.19399045
109Urticaria (HP:0001025)2.19079854
110Abnormality of T cell number (HP:0011839)2.17147278
111T lymphocytopenia (HP:0005403)2.16949444
112Ankle clonus (HP:0011448)2.16512525
113Dialeptic seizures (HP:0011146)2.14395689
114Decreased lacrimation (HP:0000633)2.13395999
115Hypergammaglobulinemia (HP:0010702)2.11358898
116Neoplasm of the tracheobronchial system (HP:0100552)2.11067288
117Optic neuritis (HP:0100653)2.09568400
118Retrobulbar optic neuritis (HP:0100654)2.09568400
119Lower limb muscle weakness (HP:0007340)2.08254443
120Cellulitis (HP:0100658)2.07572842
121Thick nail (HP:0001805)2.07209780
122Absence seizures (HP:0002121)2.06738764
123Partial agenesis of the corpus callosum (HP:0001338)2.06722424
124Excessive salivation (HP:0003781)2.05230473
125Drooling (HP:0002307)2.05230473
126Verrucae (HP:0200043)2.03374600
127Papilloma (HP:0012740)2.03374600
128Blue irides (HP:0000635)2.03020308
129Anteriorly placed anus (HP:0001545)2.01916878
130Gingival bleeding (HP:0000225)2.01582541
131Progressive inability to walk (HP:0002505)2.00873488
132Urinary urgency (HP:0000012)2.00399539
133Chronic obstructive pulmonary disease (HP:0006510)1.99724482
134Obstructive lung disease (HP:0006536)1.99724482
135Abnormality of the fingertips (HP:0001211)1.96793378
136Split foot (HP:0001839)1.95703638
137Generalized myoclonic seizures (HP:0002123)1.95532175
138Stomatitis (HP:0010280)1.94825594
139Generalized hypopigmentation of hair (HP:0011358)1.93428282
140Alveolar cell carcinoma (HP:0006519)1.92296178
141Febrile seizures (HP:0002373)1.91893689
142Osteomyelitis (HP:0002754)1.91402534
143Abnormality of salivation (HP:0100755)1.91250927
144Fair hair (HP:0002286)1.90532248
145Autoamputation (HP:0001218)1.89373218
146Absent septum pellucidum (HP:0001331)1.88160942
147Vertigo (HP:0002321)1.87051373
148Gangrene (HP:0100758)1.87013503
149Hemiparesis (HP:0001269)1.86849193
150Abnormality of saccadic eye movements (HP:0000570)1.86075642
151Combined immunodeficiency (HP:0005387)1.85479903
152Interstitial pulmonary disease (HP:0006530)1.85226176
153Stomach cancer (HP:0012126)1.84696202
154Abnormality of the pleura (HP:0002103)1.84657333
155Anorexia (HP:0002039)1.84306605
156Lymphopenia (HP:0001888)1.84175521
157Oligodactyly (hands) (HP:0001180)1.83752959
158Abnormal hair whorl (HP:0010721)1.82390973
159Hypokalemic alkalosis (HP:0001949)1.82246362
160Ectropion (HP:0000656)1.82165394
161Hypoplasia of the iris (HP:0007676)1.81970583
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.81134815
163Sepsis (HP:0100806)1.80912325
164Chin dimple (HP:0010751)1.80753411
165Increased CSF protein (HP:0002922)1.80218999
166Long nose (HP:0003189)1.77839375
167Hemiplegia (HP:0002301)1.75843294
168Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74375916
169Truncal ataxia (HP:0002078)1.74247786
170Relative macrocephaly (HP:0004482)1.72975004
171Spastic tetraparesis (HP:0001285)1.72564333
172Generalized tonic-clonic seizures (HP:0002069)1.72553433
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72403055
174Conical tooth (HP:0000698)1.72353661
175Esophageal atresia (HP:0002032)1.71391264
176Postural instability (HP:0002172)1.71083324
177Impaired vibration sensation in the lower limbs (HP:0002166)1.70919973
178Dynein arm defect of respiratory motile cilia (HP:0012255)1.70655335
179Absent/shortened dynein arms (HP:0200106)1.70655335
180Absent speech (HP:0001344)1.70095415
181Confusion (HP:0001289)1.69782273
182Aqueductal stenosis (HP:0002410)1.69100103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.70804475
2OXSR14.20054318
3EPHA43.07003646
4CDK192.92937047
5EPHB12.71895945
6TNIK2.59798745
7TAOK32.50190992
8FGFR22.40554750
9TYK22.39062007
10CASK2.30348108
11MAP3K132.25721287
12BCR2.18791631
13MST42.08516556
14PKN11.90673455
15PAK61.82954330
16SYK1.75337483
17IRAK41.73725175
18BTK1.72246700
19ZAP701.69873126
20WNK11.66518866
21RIPK41.59163244
22FGFR31.59071727
23CAMKK21.56891477
24NEK61.49024599
25WNK41.47754433
26TYRO31.46437120
27FGR1.40889334
28MAP3K141.39728031
29MET1.37797725
30MAP3K91.36885682
31BMPR21.34749409
32SGK21.34630799
33PRKCQ1.33145931
34NLK1.31638989
35PIK3CG1.31081141
36JAK21.29670439
37HCK1.28794165
38TXK1.28350832
39TEC1.26499936
40CSNK1A1L1.26142421
41CAMK2B1.22780302
42ROCK21.20453663
43TBK11.20003349
44NTRK11.18606247
45ITK1.17369525
46PRPF4B1.16542806
47MAP3K31.15040426
48GRK61.14304553
49CAMKK11.13477276
50CSNK1G21.12603523
51MAP2K31.12430962
52MAP3K11.09981222
53CSNK1G31.09191900
54RIPK11.09132564
55SGK31.09126953
56NTRK21.07811826
57MARK31.07368031
58LYN1.06211467
59CLK11.05580683
60MAP3K41.05111746
61DMPK1.04315584
62SGK4941.03995119
63SGK2231.03995119
64PAK31.02064816
65CDK51.00000780
66NTRK30.99682314
67MAPKAPK50.98072162
68FGFR40.97651818
69PNCK0.95711071
70CSNK1G10.94693177
71PBK0.94659111
72CSF1R0.94524241
73ERBB40.94372515
74STK240.93490851
75KSR20.93108723
76STK110.91776674
77SIK30.88948811
78MAP3K120.88893247
79IRAK10.88550875
80KIT0.88057267
81CAMK2A0.85529319
82MARK20.84148799
83PIM10.81786932
84MAP2K70.81311271
85PDPK10.79624778
86CAMK2D0.79603665
87GRK70.76720016
88FRK0.75770942
89TNK20.75191244
90FES0.74726570
91SCYL20.74216815
92CAMK2G0.73266049
93CHUK0.72718561
94HIPK20.71931982
95MAPK120.71463721
96PTK2B0.70930408
97RAF10.70908900
98DAPK20.70011952
99FYN0.68933021
100BRD40.68576935
101TGFBR20.68466793
102PDK10.67857141
103PRKCH0.67056893
104CDK30.66752824
105ICK0.64393882
106JAK10.63683402
107PDGFRB0.62962387
108STK100.62898950
109MAPK70.62355353
110PRKCE0.61589163
111TRPM70.61200484
112MAP3K110.60984112
113UHMK10.58501323
114NUAK10.57735824
115MAP4K10.57466342
116CAMK40.56746218
117TAOK10.55813784
118GRK50.54872476
119IRAK20.54404092
120MAP3K70.54354619
121MAP3K20.54172269
122MAPK110.53711549
123SGK10.53410416
124ARAF0.52992186
125MAP3K50.51433871
126CSNK1D0.51145270
127LCK0.50798422
128CSK0.50570136
129IKBKE0.50102367
130CDK140.50002235
131CAMK1G0.49532326
132SIK20.49163748
133CDK150.47851224
134EGFR0.47270476
135RET0.47135760
136TAOK20.46787193
137YES10.45747129
138JAK30.45506200
139MELK0.44807261
140CDK180.44551311
141PRKD10.43163484
142CDK11A0.42700819
143PIK3CA0.42694388
144CDK60.42612909
145IKBKB0.42127952
146PRKG10.40086447
147MOS0.39966524
148BLK0.39378767
149MAPK130.39280132
150EPHA30.38698560
151KSR10.38083371
152MARK10.37723996
153ABL10.37507124
154PLK20.37474042
155MAP2K60.36759416
156DYRK1A0.36486219
157LIMK10.34491684

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.27216845
2Steroid biosynthesis_Homo sapiens_hsa001002.25077807
3Leishmaniasis_Homo sapiens_hsa051402.16940325
4Glutamatergic synapse_Homo sapiens_hsa047242.02579870
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95992655
6Nitrogen metabolism_Homo sapiens_hsa009101.92726778
7Nicotine addiction_Homo sapiens_hsa050331.89881711
8Asthma_Homo sapiens_hsa053101.88151304
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.84913070
10Fatty acid elongation_Homo sapiens_hsa000621.84295063
11Measles_Homo sapiens_hsa051621.82070927
12Ether lipid metabolism_Homo sapiens_hsa005651.79522918
13Autoimmune thyroid disease_Homo sapiens_hsa053201.75636684
14Axon guidance_Homo sapiens_hsa043601.75280209
15Morphine addiction_Homo sapiens_hsa050321.74263527
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69669715
17Staphylococcus aureus infection_Homo sapiens_hsa051501.69587430
18Salivary secretion_Homo sapiens_hsa049701.65715798
19GABAergic synapse_Homo sapiens_hsa047271.63815088
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61460634
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59038052
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59033770
23Antigen processing and presentation_Homo sapiens_hsa046121.56117115
24Allograft rejection_Homo sapiens_hsa053301.55811475
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55802802
26T cell receptor signaling pathway_Homo sapiens_hsa046601.53762055
27Tuberculosis_Homo sapiens_hsa051521.52459799
28Long-term depression_Homo sapiens_hsa047301.48054553
29Long-term potentiation_Homo sapiens_hsa047201.47053640
30TNF signaling pathway_Homo sapiens_hsa046681.45588366
31Graft-versus-host disease_Homo sapiens_hsa053321.44295988
32Circadian entrainment_Homo sapiens_hsa047131.44038345
33Gastric acid secretion_Homo sapiens_hsa049711.43869248
34Influenza A_Homo sapiens_hsa051641.41566431
35Dorso-ventral axis formation_Homo sapiens_hsa043201.41405367
36Toxoplasmosis_Homo sapiens_hsa051451.40219461
37Serotonergic synapse_Homo sapiens_hsa047261.33889455
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30864477
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24471024
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24090354
41ErbB signaling pathway_Homo sapiens_hsa040121.23123592
42Renin secretion_Homo sapiens_hsa049241.22132662
43Renal cell carcinoma_Homo sapiens_hsa052111.21473981
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16937767
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15445848
46Viral myocarditis_Homo sapiens_hsa054161.14456706
47Acute myeloid leukemia_Homo sapiens_hsa052211.13756196
48Hepatitis B_Homo sapiens_hsa051611.12617698
49Sphingolipid metabolism_Homo sapiens_hsa006001.12155885
50Herpes simplex infection_Homo sapiens_hsa051681.11889270
51Amphetamine addiction_Homo sapiens_hsa050311.11832281
52Rheumatoid arthritis_Homo sapiens_hsa053231.10059327
53Non-small cell lung cancer_Homo sapiens_hsa052231.10005893
54Olfactory transduction_Homo sapiens_hsa047401.09204843
55Hepatitis C_Homo sapiens_hsa051601.07675829
56Synaptic vesicle cycle_Homo sapiens_hsa047211.06863550
57Sphingolipid signaling pathway_Homo sapiens_hsa040711.04421856
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04274654
59Phospholipase D signaling pathway_Homo sapiens_hsa040721.03295360
60Collecting duct acid secretion_Homo sapiens_hsa049661.03119264
61Chemokine signaling pathway_Homo sapiens_hsa040621.02968340
62Primary immunodeficiency_Homo sapiens_hsa053401.02387442
63Cholinergic synapse_Homo sapiens_hsa047251.02168983
64Legionellosis_Homo sapiens_hsa051341.02102833
65cAMP signaling pathway_Homo sapiens_hsa040241.01510095
66Dopaminergic synapse_Homo sapiens_hsa047281.00974860
67Ras signaling pathway_Homo sapiens_hsa040141.00525646
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98879320
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98497163
70Platelet activation_Homo sapiens_hsa046110.95801731
71Oxytocin signaling pathway_Homo sapiens_hsa049210.94153230
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93140069
73Prolactin signaling pathway_Homo sapiens_hsa049170.91872035
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91307034
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.90797374
76B cell receptor signaling pathway_Homo sapiens_hsa046620.90562876
77Pertussis_Homo sapiens_hsa051330.89762187
78Pancreatic cancer_Homo sapiens_hsa052120.89274559
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88146250
80Apoptosis_Homo sapiens_hsa042100.87049306
81Pancreatic secretion_Homo sapiens_hsa049720.85785463
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.85391855
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.84822695
84Choline metabolism in cancer_Homo sapiens_hsa052310.84583371
85Fatty acid biosynthesis_Homo sapiens_hsa000610.84258862
86Taste transduction_Homo sapiens_hsa047420.82987295
87MAPK signaling pathway_Homo sapiens_hsa040100.82908714
88Cocaine addiction_Homo sapiens_hsa050300.81404011
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80473555
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79564727
91African trypanosomiasis_Homo sapiens_hsa051430.77308356
92Calcium signaling pathway_Homo sapiens_hsa040200.77006605
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76113432
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76081926
95FoxO signaling pathway_Homo sapiens_hsa040680.75966849
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75386545
97Chronic myeloid leukemia_Homo sapiens_hsa052200.75321272
98* Endocytosis_Homo sapiens_hsa041440.73354829
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73049498
100Inositol phosphate metabolism_Homo sapiens_hsa005620.72643465
101GnRH signaling pathway_Homo sapiens_hsa049120.70214027
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70160401
103Salmonella infection_Homo sapiens_hsa051320.68453301
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68167057
105mTOR signaling pathway_Homo sapiens_hsa041500.65723741
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65607747
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64889720
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64737853
109Tight junction_Homo sapiens_hsa045300.64621172
110Insulin secretion_Homo sapiens_hsa049110.63766965
111Mineral absorption_Homo sapiens_hsa049780.62862592
112Endometrial cancer_Homo sapiens_hsa052130.61869394
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60901268
114Gap junction_Homo sapiens_hsa045400.60388422
115Malaria_Homo sapiens_hsa051440.59583057
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.56760581
117Phagosome_Homo sapiens_hsa041450.56228444
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55232809
119VEGF signaling pathway_Homo sapiens_hsa043700.54521342
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54449138
121Rap1 signaling pathway_Homo sapiens_hsa040150.53910116
122Melanogenesis_Homo sapiens_hsa049160.53769728
123Type II diabetes mellitus_Homo sapiens_hsa049300.53727879
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.52238026
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.50696984
126Ovarian steroidogenesis_Homo sapiens_hsa049130.50522401
127Vibrio cholerae infection_Homo sapiens_hsa051100.50459927
128Type I diabetes mellitus_Homo sapiens_hsa049400.49837646
129HTLV-I infection_Homo sapiens_hsa051660.49835797
130Osteoclast differentiation_Homo sapiens_hsa043800.49348222
131Viral carcinogenesis_Homo sapiens_hsa052030.48891909
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48849335
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48417376
134Epstein-Barr virus infection_Homo sapiens_hsa051690.47606966
135Estrogen signaling pathway_Homo sapiens_hsa049150.47513558
136Amoebiasis_Homo sapiens_hsa051460.46612615
137Linoleic acid metabolism_Homo sapiens_hsa005910.45127789
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44882470
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.43489446
140Insulin resistance_Homo sapiens_hsa049310.40459350
141Sulfur metabolism_Homo sapiens_hsa009200.40248588
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39985790
143Circadian rhythm_Homo sapiens_hsa047100.39244902
144Glioma_Homo sapiens_hsa052140.38055654
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.37476215

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