ARAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44812728
2negative regulation of cell killing (GO:0031342)5.44812728
3vascular endothelial growth factor signaling pathway (GO:0038084)5.31273974
4lymph vessel development (GO:0001945)4.95464240
5endothelium development (GO:0003158)4.78215504
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62958301
7detection of other organism (GO:0098543)4.57990237
8blood vessel maturation (GO:0001955)4.49056121
9surfactant homeostasis (GO:0043129)4.47866463
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.43920986
11detection of molecule of bacterial origin (GO:0032490)4.38733031
12antigen processing and presentation of endogenous antigen (GO:0019883)4.31268140
13neutrophil activation involved in immune response (GO:0002283)4.28207256
14response to peptidoglycan (GO:0032494)4.21616761
15detection of bacterium (GO:0016045)4.21089661
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.11896564
17positive regulation of gamma-delta T cell activation (GO:0046645)4.11625365
18detection of external biotic stimulus (GO:0098581)4.10067538
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06952283
20endothelial tube morphogenesis (GO:0061154)3.98976496
21morphogenesis of an endothelium (GO:0003159)3.98976496
22positive regulation of vasculogenesis (GO:2001214)3.89865409
23regulation of endothelial cell differentiation (GO:0045601)3.81838114
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.79692802
25lymphangiogenesis (GO:0001946)3.76146613
26detection of biotic stimulus (GO:0009595)3.66627484
27cardiac myofibril assembly (GO:0055003)3.65999113
28respiratory burst (GO:0045730)3.64317389
29negative regulation of erythrocyte differentiation (GO:0045647)3.62908033
30negative regulation of interleukin-12 production (GO:0032695)3.61464131
31neutrophil activation (GO:0042119)3.58525198
32regulation of vasculogenesis (GO:2001212)3.56304068
33leukocyte aggregation (GO:0070486)3.51399264
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.47291829
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46624870
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.46624870
37modulation by symbiont of host immune response (GO:0052553)3.46624870
38positive regulation by symbiont of host defense response (GO:0052509)3.46624870
39modulation by symbiont of host defense response (GO:0052031)3.46624870
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46624870
41heart trabecula formation (GO:0060347)3.41153098
42basement membrane organization (GO:0071711)3.40158647
43response to muramyl dipeptide (GO:0032495)3.39660619
44negative regulation of granulocyte differentiation (GO:0030853)3.38942497
45substrate-dependent cell migration (GO:0006929)3.35035626
46macrophage activation (GO:0042116)3.34919312
47cellular extravasation (GO:0045123)3.34850023
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.34199695
49chemical homeostasis within a tissue (GO:0048875)3.30444794
50patterning of blood vessels (GO:0001569)3.30105325
51vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.29055910
52granulocyte activation (GO:0036230)3.26852505
53sarcomere organization (GO:0045214)3.24802074
54myofibril assembly (GO:0030239)3.22621962
55negative regulation of phagocytosis (GO:0050765)3.19474760
56positive regulation of Cdc42 GTPase activity (GO:0043089)3.19233839
57regulation of interferon-beta biosynthetic process (GO:0045357)3.18641685
58antigen processing and presentation via MHC class Ib (GO:0002475)3.18481205
59neutrophil mediated immunity (GO:0002446)3.17187957
60blood vessel endothelial cell migration (GO:0043534)3.17099926
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16787562
62venous blood vessel morphogenesis (GO:0048845)3.16653269
63regulation of gamma-delta T cell activation (GO:0046643)3.14083295
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10013056
65positive regulation of receptor recycling (GO:0001921)3.07877324
66cell migration involved in sprouting angiogenesis (GO:0002042)3.07318557
67endothelial cell morphogenesis (GO:0001886)3.06808599
68regulation of mast cell degranulation (GO:0043304)3.06696297
69regulation of T-helper 2 cell differentiation (GO:0045628)3.03218465
70response to interleukin-15 (GO:0070672)3.02011437
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01647969
72glomerular filtration (GO:0003094)3.01376750
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01079550
74coronary vasculature morphogenesis (GO:0060977)3.00654655
75regulation of leukocyte degranulation (GO:0043300)3.00054436
76negative regulation of leukocyte mediated immunity (GO:0002704)2.99086063
77production of molecular mediator involved in inflammatory response (GO:0002532)2.97059589
78renal filtration (GO:0097205)2.96170113
79protein localization to endosome (GO:0036010)2.94369781
80germinal center formation (GO:0002467)2.91302611
81ovulation from ovarian follicle (GO:0001542)2.91125593
82macrophage activation involved in immune response (GO:0002281)2.89949741
83plasma membrane repair (GO:0001778)2.86990560
84low-density lipoprotein particle clearance (GO:0034383)2.84848845
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84150080
86myeloid cell activation involved in immune response (GO:0002275)2.83917636
87regulation of macrophage cytokine production (GO:0010935)2.83634820
88regulation of p38MAPK cascade (GO:1900744)2.82857943
89negative regulation of blood vessel endothelial cell migration (GO:0043537)2.82168514
90leukocyte migration involved in inflammatory response (GO:0002523)2.79770653
91apoptotic cell clearance (GO:0043277)2.77652679
92vasculogenesis (GO:0001570)2.75250915
93response to fluid shear stress (GO:0034405)2.74301034
94regulation of cholesterol storage (GO:0010885)2.73883861
95positive regulation of p38MAPK cascade (GO:1900745)2.73532389
96regulation of mast cell activation involved in immune response (GO:0033006)2.73232642
97positive regulation of histone deacetylation (GO:0031065)2.72511857
98negative regulation of type 2 immune response (GO:0002829)2.71906689
99regulation of gamma-delta T cell differentiation (GO:0045586)2.71649745
100positive regulation of cellular amide metabolic process (GO:0034250)2.71511337
101regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70973482
102regulation of T cell tolerance induction (GO:0002664)2.70373527
103endothelial cell differentiation (GO:0045446)2.69254813
104regulation of sequestering of triglyceride (GO:0010889)2.69034084
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.68868085
106fatty acid transmembrane transport (GO:1902001)2.68817038
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68415688
108response to laminar fluid shear stress (GO:0034616)2.67572935
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66621037
110myeloid leukocyte mediated immunity (GO:0002444)2.66079712
111hyaluronan catabolic process (GO:0030214)2.65557993
112cell adhesion mediated by integrin (GO:0033627)2.63185594
113negative regulation of glycoprotein biosynthetic process (GO:0010561)2.62577480
114negative regulation of stress fiber assembly (GO:0051497)2.61905572
115establishment of endothelial barrier (GO:0061028)2.61659505
116angiogenesis involved in wound healing (GO:0060055)2.61655783
117negative regulation of nitric-oxide synthase activity (GO:0051001)2.61325221
118germ cell migration (GO:0008354)2.60766347
119regulation of tolerance induction (GO:0002643)2.60174309
120regulation of sarcomere organization (GO:0060297)2.60057327
121neutrophil chemotaxis (GO:0030593)2.57714265
122stress fiber assembly (GO:0043149)2.55504879
123regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.55177063
124regulation of regulated secretory pathway (GO:1903305)2.54533791
125sprouting angiogenesis (GO:0002040)2.52841470
126endothelial cell chemotaxis (GO:0035767)2.52659025
127microglial cell activation (GO:0001774)2.52356607
128neutrophil migration (GO:1990266)2.50264722
129negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.49396052
130positive regulation of mast cell activation (GO:0033005)2.49300222
131regulation of necroptotic process (GO:0060544)2.48732458
132positive regulation of endothelial cell differentiation (GO:0045603)2.48535345
1333-UTR-mediated mRNA stabilization (GO:0070935)2.47792578
134endothelial cell migration (GO:0043542)2.47781986
135negative regulation of endothelial cell migration (GO:0010596)2.47525385
136negative regulation of glial cell proliferation (GO:0060253)2.47172946
137pinocytosis (GO:0006907)2.47079848
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46998849
139negative regulation of T cell mediated immunity (GO:0002710)2.46760509
140negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46507210
141response to host immune response (GO:0052572)2.46385458
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46385458
143apoptotic process involved in morphogenesis (GO:0060561)2.46013884
144macrophage differentiation (GO:0030225)2.45936357
145cellular response to interleukin-15 (GO:0071350)2.45934896
146leukocyte degranulation (GO:0043299)2.45630280
147regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45519853
148blood vessel remodeling (GO:0001974)2.45502944
149phospholipid homeostasis (GO:0055091)2.44649265
150negative regulation of heart growth (GO:0061117)2.43363755
151negative regulation of cardiac muscle tissue growth (GO:0055022)2.43363755
152negative regulation of interleukin-6 production (GO:0032715)2.43343472
153pathway-restricted SMAD protein phosphorylation (GO:0060389)2.42803201
154regulation of B cell receptor signaling pathway (GO:0050855)2.42705930
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41508283
156mRNA transcription from RNA polymerase II promoter (GO:0042789)2.41104904
157positive regulation of interleukin-8 secretion (GO:2000484)2.41090232
158negative regulation of platelet activation (GO:0010544)2.41076895
159semaphorin-plexin signaling pathway (GO:0071526)2.38693302
160response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38636068
161response to host (GO:0075136)2.38636068
162response to host defenses (GO:0052200)2.38636068
163cardiac muscle hypertrophy (GO:0003300)2.35622924
164positive regulation of adherens junction organization (GO:1903393)2.34926242
165positive regulation of cell junction assembly (GO:1901890)2.33381749
166positive regulation of focal adhesion assembly (GO:0051894)2.33381749
167carnitine shuttle (GO:0006853)2.30978876
168regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.29173157
169cell-substrate junction assembly (GO:0007044)2.28626168
170positive regulation of lamellipodium assembly (GO:0010592)2.27261779
171antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26992921
172actomyosin structure organization (GO:0031032)2.26823276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.32501945
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.12726905
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38077849
4GATA1_22025678_ChIP-Seq_K562_Human2.84610229
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76793802
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.66858874
7SCL_19346495_ChIP-Seq_HPC-7_Human2.61365814
8* GATA2_21666600_ChIP-Seq_HMVEC_Human2.61222410
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.58950391
10CLOCK_20551151_ChIP-Seq_293T_Human2.56833133
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55073034
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.46073242
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46005515
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26672041
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26021584
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24537629
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.22404304
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16897591
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14109259
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12534877
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10815655
22* SPI1_23127762_ChIP-Seq_K562_Human2.03932576
23TCF7_22412390_ChIP-Seq_EML_Mouse2.01307116
24VDR_21846776_ChIP-Seq_THP-1_Human2.01010686
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.99345419
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92493498
27* TBX20_22328084_ChIP-Seq_HEART_Mouse1.91159786
28* TBX20_22080862_ChIP-Seq_HEART_Mouse1.91159786
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88702106
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.88000212
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86343405
32GATA1_19941826_ChIP-Seq_K562_Human1.85218089
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81008741
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.80681821
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73607553
36KDM2B_26808549_Chip-Seq_DND41_Human1.71646340
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.68797823
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.66946266
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66798201
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66617172
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66567097
42MAF_26560356_Chip-Seq_TH1_Human1.66350752
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65002821
44RUNX_20019798_ChIP-Seq_JUKART_Human1.59521780
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58655686
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.56660174
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.56109872
48VDR_24763502_ChIP-Seq_THP-1_Human1.55690342
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55450597
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54798229
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.54247150
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53559552
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53260655
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51227170
55MAF_26560356_Chip-Seq_TH2_Human1.50908844
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49746418
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.49689231
58* LXR_22292898_ChIP-Seq_THP-1_Human1.47372302
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47010890
60MYC_22102868_ChIP-Seq_BL_Human1.46808327
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42875786
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42630757
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41284970
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41187272
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40402547
66GATA2_19941826_ChIP-Seq_K562_Human1.39656990
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35233200
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35112353
69UTX_26944678_Chip-Seq_JUKART_Human1.34570465
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32350384
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29115019
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28340475
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28249669
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27076275
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27041585
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27034439
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24461720
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24332270
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.24231806
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24089500
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24037997
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22476575
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22476575
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22476575
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21968846
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21439042
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21003708
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20930196
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19587583
90RACK7_27058665_Chip-Seq_MCF-7_Human1.18578557
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.18546806
92VDR_24787735_ChIP-Seq_THP-1_Human1.18542678
93* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18124044
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17928231
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17868764
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17020479
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16312029
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15354842
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15261419
100ZNF263_19887448_ChIP-Seq_K562_Human1.14360276
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.13317173
102* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11249820
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10319938
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10296695
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.09913410
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09648415
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08863637
108NCOR1_26117541_ChIP-Seq_K562_Human1.08430260
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08194656
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.07956704
111P68_20966046_ChIP-Seq_HELA_Human1.07000999
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06743516
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05621222
114* SPI1_23547873_ChIP-Seq_NB4_Human1.05118304
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04058706
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03607647
117* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02462325
118* KDM2B_26808549_Chip-Seq_K562_Human1.02018671
119* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01949642
120* SMC4_20622854_ChIP-Seq_HELA_Human1.01351110
121* MYB_26560356_Chip-Seq_TH1_Human1.00492688
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00479183
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00359467
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00300065
125PU_27001747_Chip-Seq_BMDM_Mouse0.99066812
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.98435092
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98073314
128MYB_26560356_Chip-Seq_TH2_Human0.97981910
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95202442
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93975078
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92960108
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92500702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.14735409
2MP0005167_abnormal_blood-brain_barrier3.78506020
3MP0001879_abnormal_lymphatic_vessel3.71585910
4MP0004084_abnormal_cardiac_muscle3.35813154
5MP0003828_pulmonary_edema2.92616128
6MP0008260_abnormal_autophagy2.66290623
7MP0003303_peritoneal_inflammation2.65982473
8MP0004272_abnormal_basement_membrane2.55199525
9MP0003191_abnormal_cellular_cholesterol2.49901458
10MP0002837_dystrophic_cardiac_calcinosis2.41648316
11MP0009278_abnormal_bone_marrow2.32835204
12MP0003724_increased_susceptibility_to2.31004585
13MP0000343_altered_response_to2.22255233
14MP0003566_abnormal_cell_adhesion2.16220297
15MP0004858_abnormal_nervous_system2.10445718
16MP0004036_abnormal_muscle_relaxation2.02374367
17MP0004215_abnormal_myocardial_fiber2.01554618
18MP0003300_gastrointestinal_ulcer2.01148817
19MP0003705_abnormal_hypodermis_morpholog2.00747794
20MP0003279_aneurysm1.96871396
21MP0005451_abnormal_body_composition1.90779046
22MP0001849_ear_inflammation1.89040755
23MP0005409_darkened_coat_color1.78358584
24MP0006138_congestive_heart_failure1.76775112
25MP0000767_abnormal_smooth_muscle1.75881459
26MP0010630_abnormal_cardiac_muscle1.75570144
27MP0004510_myositis1.75543613
28MP0004130_abnormal_muscle_cell1.73390432
29MP0005330_cardiomyopathy1.70112141
30MP0001544_abnormal_cardiovascular_syste1.67888923
31MP0005385_cardiovascular_system_phenoty1.67888923
32MP0001790_abnormal_immune_system1.64167238
33MP0005387_immune_system_phenotype1.64167238
34MP0008775_abnormal_heart_ventricle1.64035837
35MP0000751_myopathy1.63992231
36MP0002420_abnormal_adaptive_immunity1.63190489
37MP0001819_abnormal_immune_cell1.62911129
38MP0005670_abnormal_white_adipose1.62581599
39MP0005000_abnormal_immune_tolerance1.60478817
40MP0002972_abnormal_cardiac_muscle1.55862002
41MP0000465_gastrointestinal_hemorrhage1.54849240
42MP0002723_abnormal_immune_serum1.54412672
43MP0005397_hematopoietic_system_phenotyp1.53692405
44MP0001545_abnormal_hematopoietic_system1.53692405
45MP0000685_abnormal_immune_system1.53488165
46MP0000858_altered_metastatic_potential1.52634380
47MP0001958_emphysema1.51316868
48MP0001800_abnormal_humoral_immune1.50582696
49MP0005464_abnormal_platelet_physiology1.48516123
50MP0002998_abnormal_bone_remodeling1.48265079
51MP0005058_abnormal_lysosome_morphology1.45805399
52MP0004947_skin_inflammation1.44318366
53MP0004381_abnormal_hair_follicle1.43133043
54MP0000249_abnormal_blood_vessel1.42669498
55MP0002132_abnormal_respiratory_system1.41719724
56MP0006054_spinal_hemorrhage1.41409586
57MP0009840_abnormal_foam_cell1.40498887
58MP0002138_abnormal_hepatobiliary_system1.38906085
59MP0004087_abnormal_muscle_fiber1.36867096
60MP0004484_altered_response_of1.32867734
61MP0005165_increased_susceptibility_to1.32044669
62MP0003436_decreased_susceptibility_to1.25824184
63MP0000749_muscle_degeneration1.25673331
64MP0002419_abnormal_innate_immunity1.24377782
65MP0002128_abnormal_blood_circulation1.24314317
66MP0005076_abnormal_cell_differentiation1.24056239
67MP0002396_abnormal_hematopoietic_system1.22989848
68MP0001851_eye_inflammation1.22946149
69MP0005666_abnormal_adipose_tissue1.22552949
70MP0000750_abnormal_muscle_regeneration1.22075751
71MP0004185_abnormal_adipocyte_glucose1.18842409
72MP0004808_abnormal_hematopoietic_stem1.18276157
73MP0002925_abnormal_cardiovascular_devel1.16847557
74MP0005671_abnormal_response_to1.16685406
75MP0005390_skeleton_phenotype1.16050254
76MP0002398_abnormal_bone_marrow1.15720772
77MP0002933_joint_inflammation1.15378135
78MP0002332_abnormal_exercise_endurance1.13254634
79MP0000716_abnormal_immune_system1.12388438
80MP0008004_abnormal_stomach_pH1.09950966
81MP0003075_altered_response_to1.09457826
82MP0004883_abnormal_blood_vessel1.08750695
83MP0002148_abnormal_hypersensitivity_rea1.08202915
84MP0001614_abnormal_blood_vessel1.08061862
85MP0004085_abnormal_heartbeat1.07926344
86MP0000266_abnormal_heart_morphology1.06903545
87MP0005620_abnormal_muscle_contractility1.06723380
88MP0010155_abnormal_intestine_physiology1.05867096
89MP0001915_intracranial_hemorrhage1.02830241
90MP0001533_abnormal_skeleton_physiology1.02799102
91MP0002166_altered_tumor_susceptibility1.02550042
92MP0002877_abnormal_melanocyte_morpholog1.00137199
93MP0000678_abnormal_parathyroid_gland0.98845023
94MP0003172_abnormal_lysosome_physiology0.98688810
95MP0003646_muscle_fatigue0.97721111
96MP0002429_abnormal_blood_cell0.95751887
97MP0008438_abnormal_cutaneous_collagen0.95650601
98MP0002722_abnormal_immune_system0.95411695
99MP0001853_heart_inflammation0.94836568
100MP0002133_abnormal_respiratory_system0.94478536
101MP0005388_respiratory_system_phenotype0.94478536
102MP0005023_abnormal_wound_healing0.93932747
103MP0002254_reproductive_system_inflammat0.92529855
104MP0004233_abnormal_muscle_weight0.92450075
105MP0000703_abnormal_thymus_morphology0.92169125
106MP0004147_increased_porphyrin_level0.91957421
107MP0005595_abnormal_vascular_smooth0.91731572
108MP0003567_abnormal_fetal_cardiomyocyte0.91033516
109MP0003690_abnormal_glial_cell0.89977646
110MP0006082_CNS_inflammation0.89876692
111MP0003091_abnormal_cell_migration0.89600148
112MP0005164_abnormal_response_to0.88443728
113MP0003453_abnormal_keratinocyte_physiol0.88422572
114MP0005375_adipose_tissue_phenotype0.87286039
115MP0005025_abnormal_response_to0.86868499
116MP0005360_urolithiasis0.86329464
117MP0003950_abnormal_plasma_membrane0.85955541
118MP0003252_abnormal_bile_duct0.85612134
119MP0003763_abnormal_thymus_physiology0.84768791
120MP0002106_abnormal_muscle_physiology0.84728523
121MP0008469_abnormal_protein_level0.84348938
122MP0009785_altered_susceptibility_to0.83666273
123MP0005377_hearing/vestibular/ear_phenot0.83542660
124MP0003878_abnormal_ear_physiology0.83542660
125MP0010329_abnormal_lipoprotein_level0.82414599
126MP0004782_abnormal_surfactant_physiolog0.81425545
127MP0000689_abnormal_spleen_morphology0.80620458
128MP0001835_abnormal_antigen_presentation0.80296656
129MP0002127_abnormal_cardiovascular_syste0.80071442
130MP0009053_abnormal_anal_canal0.79601054
131MP0009333_abnormal_splenocyte_physiolog0.79250896
132MP0005248_abnormal_Harderian_gland0.78844997
133MP0009764_decreased_sensitivity_to0.78273389
134MP0008961_abnormal_basal_metabolism0.77749198
135MP0000609_abnormal_liver_physiology0.75947627
136MP0005319_abnormal_enzyme/_coenzyme0.74368341
137MP0005166_decreased_susceptibility_to0.72741102
138MP0003221_abnormal_cardiomyocyte_apopto0.72581769
139MP0002452_abnormal_antigen_presenting0.70829399
140MP0000230_abnormal_systemic_arterial0.68490145
141MP0003448_altered_tumor_morphology0.68398028
142MP0002405_respiratory_system_inflammati0.68202644
143MP0002269_muscular_atrophy0.68167343
144MP0003045_fibrosis0.67930141
145MP0001845_abnormal_inflammatory_respons0.67879222

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)5.43850672
2Polycythemia (HP:0001901)5.05715078
3Spontaneous hematomas (HP:0007420)4.79813186
4Cerebral aneurysm (HP:0004944)4.50548394
5Myositis (HP:0100614)4.38148375
6Orchitis (HP:0100796)4.17390160
7Ventricular tachycardia (HP:0004756)3.94115575
8Sudden death (HP:0001699)3.71871619
9Systemic lupus erythematosus (HP:0002725)3.67655889
10Optic neuritis (HP:0100653)3.48334540
11Retrobulbar optic neuritis (HP:0100654)3.48334540
12Esophageal varix (HP:0002040)3.38742593
13Muscle fiber splitting (HP:0003555)3.35860124
14Eczematoid dermatitis (HP:0000976)3.28746533
15Peritonitis (HP:0002586)3.22911624
16Obstructive lung disease (HP:0006536)3.19093171
17Chronic obstructive pulmonary disease (HP:0006510)3.19093171
18Lymphangioma (HP:0100764)3.13078578
19Gingivitis (HP:0000230)3.13050365
20Elevated erythrocyte sedimentation rate (HP:0003565)3.09749195
21Recurrent abscess formation (HP:0002722)3.05613182
22Asymmetric septal hypertrophy (HP:0001670)3.03118202
23Atrial fibrillation (HP:0005110)3.01400436
24Increased connective tissue (HP:0009025)2.99804536
25Gastrointestinal infarctions (HP:0005244)2.97238499
26Abnormality of the nasal mucosa (HP:0000433)2.97228594
27Hyporeflexia of lower limbs (HP:0002600)2.96667089
28Cellulitis (HP:0100658)2.92275593
29Complement deficiency (HP:0004431)2.90538207
30Glomerulonephritis (HP:0000099)2.90394262
31Lipoatrophy (HP:0100578)2.84736247
32Aortic aneurysm (HP:0004942)2.84042712
33Supraventricular arrhythmia (HP:0005115)2.81691126
34Primary atrial arrhythmia (HP:0001692)2.79515770
35Increased IgE level (HP:0003212)2.79306501
36Metaphyseal cupping (HP:0003021)2.76326392
37Recurrent bacterial skin infections (HP:0005406)2.75772789
38Recurrent gram-negative bacterial infections (HP:0005420)2.75477559
39Abnormal vertebral ossification (HP:0100569)2.73304178
40Deep venous thrombosis (HP:0002625)2.72786928
41Keratoconjunctivitis sicca (HP:0001097)2.72767331
42Stomatitis (HP:0010280)2.71647785
43Hypochromic microcytic anemia (HP:0004840)2.68388623
44Supraventricular tachycardia (HP:0004755)2.66314571
45Protrusio acetabuli (HP:0003179)2.64128674
46Abnormal platelet function (HP:0011869)2.63360334
47Impaired platelet aggregation (HP:0003540)2.63360334
48Subaortic stenosis (HP:0001682)2.62779365
49Abnormality of the left ventricular outflow tract (HP:0011103)2.62779365
50Visceral angiomatosis (HP:0100761)2.62550826
51Conjunctival telangiectasia (HP:0000524)2.61691263
52Chest pain (HP:0100749)2.59793459
53Aneurysm (HP:0002617)2.59776892
54Mediastinal lymphadenopathy (HP:0100721)2.55369330
55Broad metatarsal (HP:0001783)2.53748205
56Exercise-induced muscle cramps (HP:0003710)2.52769788
57Hemangiomatosis (HP:0007461)2.52416281
58Right ventricular cardiomyopathy (HP:0011663)2.50547786
59Cerebral hemorrhage (HP:0001342)2.48296274
60Difficulty running (HP:0009046)2.47994936
61Disproportionate tall stature (HP:0001519)2.47874866
62Obstructive sleep apnea (HP:0002870)2.45065119
63Increased variability in muscle fiber diameter (HP:0003557)2.45053874
64Axonal loss (HP:0003447)2.43224163
65Interstitial pulmonary disease (HP:0006530)2.42418613
66Segmental peripheral demyelination/remyelination (HP:0003481)2.41963669
67Prolonged bleeding time (HP:0003010)2.41252334
68Nonimmune hydrops fetalis (HP:0001790)2.40807207
69Nephritis (HP:0000123)2.38984704
70Recurrent fungal infections (HP:0002841)2.38661683
71Keratoconjunctivitis (HP:0001096)2.36826270
72Hemorrhage of the eye (HP:0011885)2.34612720
73Urticaria (HP:0001025)2.31810665
74Recurrent skin infections (HP:0001581)2.30611449
75Atrioventricular block (HP:0001678)2.30603314
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30407177
77Arterial tortuosity (HP:0005116)2.27959874
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25807160
79Abnormality of skeletal muscle fiber size (HP:0012084)2.25069623
80Meningitis (HP:0001287)2.24843301
81Mucosal telangiectasiae (HP:0100579)2.24416445
82Dilated cardiomyopathy (HP:0001644)2.23686858
83Hemoptysis (HP:0002105)2.23528286
84Pulmonary artery stenosis (HP:0004415)2.19559121
85Dilatation of the ascending aorta (HP:0005111)2.17378417
86Mitral valve prolapse (HP:0001634)2.17331278
87Bicuspid aortic valve (HP:0001647)2.15979532
88Broad face (HP:0000283)2.15543715
89Abnormality of the peritoneum (HP:0002585)2.14473452
90Hypochromic anemia (HP:0001931)2.14444364
91Striae distensae (HP:0001065)2.12255828
92Cavernous hemangioma (HP:0001048)2.12066295
93Abnormality of complement system (HP:0005339)2.11775649
94Myoglobinuria (HP:0002913)2.11506937
95Arterial thrombosis (HP:0004420)2.11134299
96Increased cerebral lipofuscin (HP:0011813)2.09601221
97Syncope (HP:0001279)2.09390664
98Episodic fever (HP:0001954)2.07835795
99Vascular tortuosity (HP:0004948)2.07662154
100EMG: myopathic abnormalities (HP:0003458)2.06680320
101Calf muscle hypertrophy (HP:0008981)2.06536527
102Neonatal death (HP:0003811)2.05400448
103Subacute progressive viral hepatitis (HP:0006572)2.05123665
104Bone cyst (HP:0012062)2.03755698
105Encephalitis (HP:0002383)2.01538026
106Cervical subluxation (HP:0003308)2.00541901
107Shallow orbits (HP:0000586)2.00448686
108Exercise-induced myalgia (HP:0003738)1.99841865
109Colitis (HP:0002583)1.99567070
110Polygenic inheritance (HP:0010982)1.99487181
111Epistaxis (HP:0000421)1.97980671
112Pulmonary embolism (HP:0002204)1.97414759
113Tetraparesis (HP:0002273)1.94851197
114Heart block (HP:0012722)1.94081332
115Abnormality of macrophages (HP:0004311)1.93636040
116Myocardial infarction (HP:0001658)1.93162881
117Urethral obstruction (HP:0000796)1.93119209
118Joint hemorrhage (HP:0005261)1.92999230
119Aortic dissection (HP:0002647)1.92961855
120Abnormal delayed hypersensitivity skin test (HP:0002963)1.92458305
121Facial diplegia (HP:0001349)1.91560074
122Premature loss of primary teeth (HP:0006323)1.91491240
123Premature rupture of membranes (HP:0001788)1.90419145
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.89892785
125Vasculitis (HP:0002633)1.89830280
126Microcytic anemia (HP:0001935)1.89692961
127Hemiplegia (HP:0002301)1.87680075
128Mesangial abnormality (HP:0001966)1.86408291
129Skull defect (HP:0001362)1.80313362
130Abnormal atrioventricular conduction (HP:0005150)1.79828124
131Stroke (HP:0001297)1.78127700
132Long toe (HP:0010511)1.76576753
133Difficulty climbing stairs (HP:0003551)1.76481900
134Menorrhagia (HP:0000132)1.76288774
135Rhabdomyolysis (HP:0003201)1.76236699
136Blue sclerae (HP:0000592)1.76213959
137Abnormal platelet volume (HP:0011876)1.75641410
138Abnormality of the endocardium (HP:0004306)1.75033968
139Osteomyelitis (HP:0002754)1.74811436
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.74453790
141Portal hypertension (HP:0001409)1.74421064
142Recurrent cutaneous fungal infections (HP:0011370)1.73618157
143Chronic mucocutaneous candidiasis (HP:0002728)1.73618157
144Cardiomegaly (HP:0001640)1.73354393
145Increased mean platelet volume (HP:0011877)1.73051915
146Sepsis (HP:0100806)1.72935929
147Thoracic kyphosis (HP:0002942)1.72387038
148Abnormality of the calf musculature (HP:0001430)1.72284135
149Onion bulb formation (HP:0003383)1.71953386
150Gastrointestinal inflammation (HP:0004386)1.71949783
151Palpitations (HP:0001962)1.71715992
152Bundle branch block (HP:0011710)1.71483209
153Muscle hypertrophy of the lower extremities (HP:0008968)1.71476266
154Hypoglycemic coma (HP:0001325)1.71367958
155Hepatosplenomegaly (HP:0001433)1.71198110
156Distal lower limb muscle weakness (HP:0009053)1.70708995
157Prolonged QT interval (HP:0001657)1.70688954
158Amyloidosis (HP:0011034)1.70678241
159Distal lower limb amyotrophy (HP:0008944)1.68222183
160Anorexia (HP:0002039)1.66640398
161Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64692365
162Short 4th metacarpal (HP:0010044)1.64692365
163Gingival bleeding (HP:0000225)1.64649812
164Hypertriglyceridemia (HP:0002155)1.64206465
165Inflammation of the large intestine (HP:0002037)1.63312833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.58720704
2TGFBR24.99739497
3KDR4.82339209
4RIPK43.39721085
5TTN2.85593742
6TRIB32.73105944
7PKN22.59380896
8ERN12.22167670
9RIPK12.16377091
10MAP2K32.04930322
11EPHB11.94921350
12TAOK11.93248551
13CAMK1D1.88126961
14SMG11.86569657
15PTK61.86549867
16TNK21.82556689
17PAK41.78891596
18TGFBR11.78169859
19PRPF4B1.77383246
20MARK21.74501481
21FGR1.60554940
22DMPK1.59285752
23CAMK1G1.58155365
24PTK2B1.46107531
25PRKD21.45846854
26MAP4K11.42556748
27KSR21.41570591
28TYK21.33258434
29MAP3K61.30283170
30STK101.29276489
31MYLK1.28654876
32MAP3K131.24545032
33KIT1.21341510
34YES11.21182554
35GRK61.13663168
36TBK11.10028240
37LRRK21.09835914
38MAP3K31.08785632
39CSK1.08323097
40CSF1R1.08117176
41FES1.05334289
42ZAP701.01608190
43JAK11.00114105
44CDC42BPA0.99224776
45PRKG20.98393052
46MAPK120.97177455
47MAPK150.95981420
48SIK30.93344301
49EPHB20.90653640
50MAP3K100.89795918
51TEC0.88780606
52GRK70.87900810
53FGFR40.86935945
54PRKD10.86541694
55PDGFRA0.86186592
56PRKAA20.83383208
57IRAK20.83168539
58BMX0.82353687
59HCK0.81197100
60EEF2K0.79720887
61RPS6KA20.79634718
62ITK0.78043172
63IRAK40.77118511
64IRAK30.74584859
65JAK20.73077363
66TRPM70.72793512
67MAP3K140.72022065
68LYN0.69355969
69IRAK10.69178186
70BTK0.68683592
71SIK10.68025044
72CDK190.67571865
73FGFR30.67538252
74PTK20.67049937
75STK380.66028615
76LMTK20.66017188
77MAPK70.65763592
78CLK10.65349667
79NEK90.64994205
80SIK20.64782009
81MAP3K70.64512688
82FLT30.64397172
83CAMK40.64210425
84MAPKAPK30.63530768
85NTRK10.61853782
86MAP3K110.61219782
87GRK10.60903834
88BCKDK0.60714896
89TAOK20.59046234
90MAP3K80.58939030
91DYRK1B0.58787414
92PDPK10.58538823
93STK110.58356527
94MARK30.58012564
95PDK20.57060678
96SGK30.56592504
97OBSCN0.55910827
98CDK60.55105010
99FYN0.54372672
100JAK30.54328003
101SYK0.52589815
102PDGFRB0.50538919
103MOS0.49942438
104PAK20.49519983
105EGFR0.48620238
106TAOK30.48450766
107MAP2K40.48415224
108ILK0.47823946
109PRKCH0.47504191
110ICK0.47134239
111KSR10.46255627
112MATK0.46045020
113MAP3K20.45349672
114INSRR0.43472534
115CDK120.43070358
116MTOR0.42581943
117GSK3A0.41640794
118PHKG10.41537773
119PHKG20.41537773
120TESK20.41310784
121IKBKE0.40225950
122HIPK20.39679791
123STK240.38744519
124TYRO30.38501908
125LCK0.37580789
126STK40.37342211
127FGFR20.36530890
128IGF1R0.35823916
129PDK10.35669435
130RET0.34820095
131MAPK40.33473363
132MAP3K10.33370747
133FER0.32796969
134RPS6KC10.32557338
135RPS6KL10.32557338
136PRKAA10.32227389
137RPS6KA60.32206261
138STK30.30597232
139BLK0.29448411
140MAPKAPK20.28258314

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.72035338
2Caffeine metabolism_Homo sapiens_hsa002322.04917921
3Leukocyte transendothelial migration_Homo sapiens_hsa046702.03898510
4Dilated cardiomyopathy_Homo sapiens_hsa054141.95561777
5Osteoclast differentiation_Homo sapiens_hsa043801.91793055
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89045403
7Leishmaniasis_Homo sapiens_hsa051401.81556700
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81121433
9Fatty acid degradation_Homo sapiens_hsa000711.81050355
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.77694235
11Complement and coagulation cascades_Homo sapiens_hsa046101.73547593
12Focal adhesion_Homo sapiens_hsa045101.70389921
13Platelet activation_Homo sapiens_hsa046111.62168150
14ECM-receptor interaction_Homo sapiens_hsa045121.59466921
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59233121
16Viral myocarditis_Homo sapiens_hsa054161.57915726
17Toxoplasmosis_Homo sapiens_hsa051451.53844501
18Insulin resistance_Homo sapiens_hsa049311.45959973
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44582998
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43875569
21Adherens junction_Homo sapiens_hsa045201.39691853
22PPAR signaling pathway_Homo sapiens_hsa033201.39469146
23B cell receptor signaling pathway_Homo sapiens_hsa046621.36635909
24Non-small cell lung cancer_Homo sapiens_hsa052231.35868084
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32470165
26Amoebiasis_Homo sapiens_hsa051461.31445780
27Pertussis_Homo sapiens_hsa051331.31187522
28Small cell lung cancer_Homo sapiens_hsa052221.31114055
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31055494
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28954606
31Other glycan degradation_Homo sapiens_hsa005111.28840248
32Notch signaling pathway_Homo sapiens_hsa043301.26667159
33Lysine degradation_Homo sapiens_hsa003101.23882881
34Propanoate metabolism_Homo sapiens_hsa006401.17529854
35Arginine biosynthesis_Homo sapiens_hsa002201.16988390
36VEGF signaling pathway_Homo sapiens_hsa043701.13573391
37Endometrial cancer_Homo sapiens_hsa052131.11825046
38Phagosome_Homo sapiens_hsa041451.11339980
39Fatty acid metabolism_Homo sapiens_hsa012121.11319749
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.11199008
41Chronic myeloid leukemia_Homo sapiens_hsa052201.10489046
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10432935
43Malaria_Homo sapiens_hsa051441.10149981
44Nitrogen metabolism_Homo sapiens_hsa009101.10139011
45Hematopoietic cell lineage_Homo sapiens_hsa046401.10109400
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09151374
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09073253
48T cell receptor signaling pathway_Homo sapiens_hsa046601.08293806
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04632266
50Lysosome_Homo sapiens_hsa041421.02187749
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01172946
52Dorso-ventral axis formation_Homo sapiens_hsa043201.00951782
53Bladder cancer_Homo sapiens_hsa052191.00895492
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98362556
55GnRH signaling pathway_Homo sapiens_hsa049120.98327970
56Colorectal cancer_Homo sapiens_hsa052100.97908364
57ABC transporters_Homo sapiens_hsa020100.97325616
58Hepatitis C_Homo sapiens_hsa051600.97208288
59Proteoglycans in cancer_Homo sapiens_hsa052050.96169152
60* Rap1 signaling pathway_Homo sapiens_hsa040150.93940796
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93597270
62HIF-1 signaling pathway_Homo sapiens_hsa040660.93379106
63Thyroid cancer_Homo sapiens_hsa052160.92294901
64Renal cell carcinoma_Homo sapiens_hsa052110.91478217
65Choline metabolism in cancer_Homo sapiens_hsa052310.90684761
66Prolactin signaling pathway_Homo sapiens_hsa049170.89855220
67ErbB signaling pathway_Homo sapiens_hsa040120.88691829
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88410642
69Acute myeloid leukemia_Homo sapiens_hsa052210.87160701
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85621850
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85556437
72Pancreatic cancer_Homo sapiens_hsa052120.85336302
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84059575
74FoxO signaling pathway_Homo sapiens_hsa040680.81591457
75Tuberculosis_Homo sapiens_hsa051520.81290432
76Prostate cancer_Homo sapiens_hsa052150.79618517
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79159829
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.79065683
79TNF signaling pathway_Homo sapiens_hsa046680.79054873
80Tryptophan metabolism_Homo sapiens_hsa003800.78868061
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.77959531
82Bile secretion_Homo sapiens_hsa049760.77806393
83Herpes simplex infection_Homo sapiens_hsa051680.77363960
84Glioma_Homo sapiens_hsa052140.76328684
85Legionellosis_Homo sapiens_hsa051340.75707640
86Salmonella infection_Homo sapiens_hsa051320.75351124
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74717623
88Carbon metabolism_Homo sapiens_hsa012000.74540624
89Chemokine signaling pathway_Homo sapiens_hsa040620.73911250
90Axon guidance_Homo sapiens_hsa043600.71603376
91Influenza A_Homo sapiens_hsa051640.71472571
92MAPK signaling pathway_Homo sapiens_hsa040100.68553333
93Measles_Homo sapiens_hsa051620.68362857
94Apoptosis_Homo sapiens_hsa042100.67762647
95Starch and sucrose metabolism_Homo sapiens_hsa005000.66629534
96Inositol phosphate metabolism_Homo sapiens_hsa005620.66537097
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65998356
98mTOR signaling pathway_Homo sapiens_hsa041500.65924315
99Ras signaling pathway_Homo sapiens_hsa040140.65175046
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65126149
101Shigellosis_Homo sapiens_hsa051310.64163171
102Viral carcinogenesis_Homo sapiens_hsa052030.63998599
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63791187
104HTLV-I infection_Homo sapiens_hsa051660.63257628
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63142563
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.63003279
107Insulin signaling pathway_Homo sapiens_hsa049100.63003131
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62839679
109Graft-versus-host disease_Homo sapiens_hsa053320.62690885
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.61382677
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59608243
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59162933
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57662494
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.57450510
115Estrogen signaling pathway_Homo sapiens_hsa049150.57078669
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56808625
117AMPK signaling pathway_Homo sapiens_hsa041520.56654544
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56604341
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.56185970
120* Endocytosis_Homo sapiens_hsa041440.55036349
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.54686126
122Pathways in cancer_Homo sapiens_hsa052000.54344744
123Hepatitis B_Homo sapiens_hsa051610.54215969
124Renin-angiotensin system_Homo sapiens_hsa046140.54124443
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49786007
126Prion diseases_Homo sapiens_hsa050200.49586024
127Renin secretion_Homo sapiens_hsa049240.49403579
128African trypanosomiasis_Homo sapiens_hsa051430.49101820
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48372294
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47950518
131MicroRNAs in cancer_Homo sapiens_hsa052060.47607925
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46211954
133Antigen processing and presentation_Homo sapiens_hsa046120.45471759
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44928566
135Type II diabetes mellitus_Homo sapiens_hsa049300.44228064

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