ARCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* Golgi transport vesicle coating (GO:0048200)8.40762318
2* COPI coating of Golgi vesicle (GO:0048205)8.40762318
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.13241821
4COPII vesicle coating (GO:0048208)5.71396339
5protein retention in ER lumen (GO:0006621)5.50994360
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.89576433
7positive regulation of nuclease activity (GO:0032075)4.77599970
8folic acid-containing compound biosynthetic process (GO:0009396)4.58043424
9regulation of nuclease activity (GO:0032069)4.41508022
10* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.39360835
11endoplasmic reticulum unfolded protein response (GO:0030968)4.32159090
12cell adhesion mediated by integrin (GO:0033627)4.31799582
13cellular response to unfolded protein (GO:0034620)4.18077368
14exocrine pancreas development (GO:0031017)4.06587562
15ER-nucleus signaling pathway (GO:0006984)4.03372811
16* vesicle coating (GO:0006901)3.96187316
17cellular response to topologically incorrect protein (GO:0035967)3.93791166
18protein localization to endosome (GO:0036010)3.92636536
194-hydroxyproline metabolic process (GO:0019471)3.84426594
20intestinal cholesterol absorption (GO:0030299)3.75717168
21UDP-N-acetylglucosamine metabolic process (GO:0006047)3.69760241
22desmosome organization (GO:0002934)3.58075935
23pore complex assembly (GO:0046931)3.47927765
24intestinal absorption (GO:0050892)3.44460361
25response to endoplasmic reticulum stress (GO:0034976)3.42004835
26sequestering of metal ion (GO:0051238)3.38456249
27basement membrane organization (GO:0071711)3.29540452
28regulation of RNA export from nucleus (GO:0046831)3.27977048
29cell-substrate junction assembly (GO:0007044)3.20902722
30response to unfolded protein (GO:0006986)3.19759364
31hemidesmosome assembly (GO:0031581)3.19181207
32valine metabolic process (GO:0006573)3.15915037
33hypotonic response (GO:0006971)3.15057181
34L-alpha-amino acid transmembrane transport (GO:1902475)3.08787449
35tetrahydrofolate metabolic process (GO:0046653)3.08064981
36signal peptide processing (GO:0006465)3.07957194
37ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.07315898
38protein maturation by protein folding (GO:0022417)3.07288078
39response to topologically incorrect protein (GO:0035966)3.06303970
40adherens junction assembly (GO:0034333)3.05345482
41epithelial cell-cell adhesion (GO:0090136)3.05275037
42regulation of nucleobase-containing compound transport (GO:0032239)3.04710147
43protein localization to microtubule (GO:0035372)3.03946368
44focal adhesion assembly (GO:0048041)3.01506374
45cell-substrate adherens junction assembly (GO:0007045)3.01506374
46peptidyl-asparagine modification (GO:0018196)2.99531898
47protein N-linked glycosylation via asparagine (GO:0018279)2.98036062
48regulation of early endosome to late endosome transport (GO:2000641)2.96722607
49embryonic process involved in female pregnancy (GO:0060136)2.92750027
50mitotic chromosome condensation (GO:0007076)2.90566545
51nuclear pore organization (GO:0006999)2.87119113
52endocrine pancreas development (GO:0031018)2.85330438
53endodermal cell differentiation (GO:0035987)2.81709485
54nuclear pore complex assembly (GO:0051292)2.81237123
55lysine metabolic process (GO:0006553)2.80177495
56lysine catabolic process (GO:0006554)2.80177495
57cellular response to vitamin D (GO:0071305)2.78394470
58Golgi organization (GO:0007030)2.77379341
59regulation of cholesterol homeostasis (GO:2000188)2.77364769
60tricarboxylic acid metabolic process (GO:0072350)2.76746058
61regulation of mitotic spindle organization (GO:0060236)2.76579604
62ER to Golgi vesicle-mediated transport (GO:0006888)2.76336691
63mammary gland epithelial cell proliferation (GO:0033598)2.75980467
64regulation of transforming growth factor beta2 production (GO:0032909)2.74153162
65mesodermal cell differentiation (GO:0048333)2.73001853
66chondrocyte proliferation (GO:0035988)2.72777558
67protein N-linked glycosylation (GO:0006487)2.72040747
68protein autoprocessing (GO:0016540)2.71613326
69activation of Rac GTPase activity (GO:0032863)2.71608186
70barbed-end actin filament capping (GO:0051016)2.71016070
71cysteine metabolic process (GO:0006534)2.68863870
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.68346016
73pteridine-containing compound biosynthetic process (GO:0042559)2.67837228
74intestinal epithelial cell development (GO:0060576)2.67828322
75paraxial mesoderm development (GO:0048339)2.67587598
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.66051577
77branching involved in mammary gland duct morphogenesis (GO:0060444)2.65728186
78peptide catabolic process (GO:0043171)2.64465544
79glucocorticoid receptor signaling pathway (GO:0042921)2.64317482
80type B pancreatic cell development (GO:0003323)2.63218359
81protein export from nucleus (GO:0006611)2.61710055
82peptidyl-proline hydroxylation (GO:0019511)2.61671091
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61257560
84chondrocyte development (GO:0002063)2.60057617
85DNA unwinding involved in DNA replication (GO:0006268)2.59718840
86protein carboxylation (GO:0018214)2.59237285
87peptidyl-glutamic acid carboxylation (GO:0017187)2.59237285
88one-carbon metabolic process (GO:0006730)2.58958092
89alpha-linolenic acid metabolic process (GO:0036109)2.58758283
90regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57161333
91membrane protein ectodomain proteolysis (GO:0006509)2.57052383
92negative regulation of protein localization to plasma membrane (GO:1903077)2.56770096
93protein hydroxylation (GO:0018126)2.56595365
94positive regulation of hormone biosynthetic process (GO:0046886)2.56111912
95substrate-dependent cell migration (GO:0006929)2.55925044
96cellular copper ion homeostasis (GO:0006878)2.54495476
97mitotic sister chromatid cohesion (GO:0007064)2.54222778
98positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53847996
99stress fiber assembly (GO:0043149)2.52397849
100peptide hormone processing (GO:0016486)2.51972879
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51703810
102nucleotide-sugar biosynthetic process (GO:0009226)2.51665978
103membrane raft organization (GO:0031579)2.51359008
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50907548
105L-phenylalanine catabolic process (GO:0006559)2.50907548
106negative regulation of fibrinolysis (GO:0051918)2.50408096
107wound healing, spreading of epidermal cells (GO:0035313)2.49782521
108ribosome assembly (GO:0042255)2.49149707
109apoptotic cell clearance (GO:0043277)2.48324355
110regulation of transforming growth factor beta1 production (GO:0032908)2.47861034
111actin filament depolymerization (GO:0030042)2.47007599
112low-density lipoprotein particle clearance (GO:0034383)2.46352957
113folic acid-containing compound metabolic process (GO:0006760)2.46064202
114regulation of translational fidelity (GO:0006450)2.45811671
115collagen fibril organization (GO:0030199)2.45485729
116positive regulation of glycolytic process (GO:0045821)2.45067952
117maternal placenta development (GO:0001893)2.44793690
118homocysteine metabolic process (GO:0050667)2.43291872
119cellular protein complex localization (GO:0034629)2.42871800
120regulation of NFAT protein import into nucleus (GO:0051532)2.42575790
121mitotic cytokinesis (GO:0000281)2.42290557
122cytoskeleton-dependent cytokinesis (GO:0061640)2.42170654
123L-phenylalanine metabolic process (GO:0006558)2.41766885
124erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.41766885
125folic acid metabolic process (GO:0046655)2.41748134
126glycine metabolic process (GO:0006544)2.41472836
127macroautophagy (GO:0016236)2.41333169
128cellular zinc ion homeostasis (GO:0006882)2.40103746
129regulation of extracellular matrix disassembly (GO:0010715)2.39850939
130regulation of translational termination (GO:0006449)2.39537316
131sulfur amino acid catabolic process (GO:0000098)2.37896942
132ER overload response (GO:0006983)2.37291966
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36658136
134cellular response to vitamin (GO:0071295)2.36215762
135positive regulation of cell size (GO:0045793)2.36138681
136negative regulation of fatty acid transport (GO:2000192)2.35233990
137localization within membrane (GO:0051668)2.33807059
138regulation of histone H3-K27 methylation (GO:0061085)2.32913439
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.32473019
140negative regulation of anoikis (GO:2000811)2.31923093
141keratan sulfate catabolic process (GO:0042340)2.31533813
142lipoprotein metabolic process (GO:0042157)2.30314935
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.30101907
144L-serine transport (GO:0015825)2.30012299
145transcytosis (GO:0045056)2.29999678
146IMP biosynthetic process (GO:0006188)2.29121400
147proline biosynthetic process (GO:0006561)2.27808374
148columnar/cuboidal epithelial cell development (GO:0002066)2.26696846
149serine family amino acid biosynthetic process (GO:0009070)2.26111352
150hormone catabolic process (GO:0042447)2.25987637
151corticosteroid receptor signaling pathway (GO:0031958)2.23814092
152histone-serine phosphorylation (GO:0035404)2.23740645
153glandular epithelial cell development (GO:0002068)2.22893374
154iron ion import (GO:0097286)2.22765685
155positive regulation of histone deacetylation (GO:0031065)2.22763489
156skin morphogenesis (GO:0043589)2.22497730
157regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.21194487
158mitotic nuclear envelope disassembly (GO:0007077)2.19937502
159hippo signaling (GO:0035329)2.19918701
160positive regulation of SMAD protein import into nucleus (GO:0060391)2.19756267
161growth hormone receptor signaling pathway (GO:0060396)2.19727563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.30422288
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.03461824
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.90911740
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58469510
5CLOCK_20551151_ChIP-Seq_293T_Human3.20296373
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99683331
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.84311592
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74955312
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.73257175
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71130323
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.56692101
12ZNF263_19887448_ChIP-Seq_K562_Human2.44028181
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.32681701
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.30564123
15GATA1_22025678_ChIP-Seq_K562_Human2.30515278
16AR_21909140_ChIP-Seq_LNCAP_Human2.29017422
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22237213
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13212053
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03840310
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99322680
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93703529
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83585866
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.77390854
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76322197
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76080712
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73384693
27MYC_22102868_ChIP-Seq_BL_Human1.71431865
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69469636
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69144681
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69063791
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66248218
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.65873065
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61502596
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59933641
35* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57789513
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57482057
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57178461
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55482271
39CHD1_26751641_Chip-Seq_LNCaP_Human1.53232645
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51788217
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50362940
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50269817
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.49735282
44RACK7_27058665_Chip-Seq_MCF-7_Human1.49492042
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.48397651
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45198294
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43418558
48TFEB_21752829_ChIP-Seq_HELA_Human1.42385228
49GATA6_25053715_ChIP-Seq_YYC3_Human1.42275641
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41229964
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.39293538
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38732559
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38515690
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.34048030
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32875021
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30473693
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30383054
58ATF3_27146783_Chip-Seq_COLON_Human1.29859960
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29362640
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28237921
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28179510
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27266068
63GATA4_25053715_ChIP-Seq_YYC3_Human1.26047433
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25532759
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24240720
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22827830
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22700165
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22611026
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.22164872
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21514167
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21302660
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21208782
73* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20776109
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20697992
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20238385
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18913779
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16419754
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15845960
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15578387
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15571338
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15066440
82ELK1_19687146_ChIP-ChIP_HELA_Human1.14824589
83KDM5A_27292631_Chip-Seq_BREAST_Human1.14425145
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13751754
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13619500
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13601302
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13576237
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11028043
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10867385
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10687077
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10348769
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08568070
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08451823
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.08146859
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07929077
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07725115
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.07221804
98* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07019476
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06979586
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06300193
101BRD4_25478319_ChIP-Seq_HGPS_Human1.06194097
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04862887
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04862887
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04295148
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03847031
106TCF7_22412390_ChIP-Seq_EML_Mouse1.02563887
107GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02496085
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01813060
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01274143
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01104077
111* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00709349
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00700300
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.00507268
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.00507268
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99027437
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98474779
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.98202185
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98170635
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97442262
120BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97245117
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96898531
122GABP_19822575_ChIP-Seq_HepG2_Human0.95884320
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95796334
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.95622608
125GABP_17652178_ChIP-ChIP_JURKAT_Human0.94936473
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.94934671
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94826270
128* XRN2_22483619_ChIP-Seq_HELA_Human0.94103240
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.93518773
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92993702
131DCP1A_22483619_ChIP-Seq_HELA_Human0.92768470
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92663751
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91476256
134* NCOR1_26117541_ChIP-Seq_K562_Human0.90555550
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90475573
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90183339
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.89741745
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89212812
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88947593
140CIITA_25753668_ChIP-Seq_RAJI_Human0.88375862
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.87650151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.33937428
2MP0008438_abnormal_cutaneous_collagen3.32225652
3MP0002139_abnormal_hepatobiliary_system3.00468218
4MP0006054_spinal_hemorrhage2.81239130
5MP0002877_abnormal_melanocyte_morpholog2.79915786
6MP0010352_gastrointestinal_tract_polyps2.55623633
7MP0005257_abnormal_intraocular_pressure2.55485066
8MP0005360_urolithiasis2.50822298
9MP0003300_gastrointestinal_ulcer2.44307376
10MP0005365_abnormal_bile_salt2.42358319
11MP0005623_abnormal_meninges_morphology2.37262655
12MP0005275_abnormal_skin_tensile2.16732971
13MP0005220_abnormal_exocrine_pancreas2.16390937
14MP0004264_abnormal_extraembryonic_tissu2.11292086
15MP0010234_abnormal_vibrissa_follicle2.10269482
16MP0003941_abnormal_skin_development2.07073564
17MP0001666_abnormal_nutrient_absorption2.03933044
18MP0005085_abnormal_gallbladder_physiolo2.03030888
19MP0003252_abnormal_bile_duct2.02651493
20MP0003806_abnormal_nucleotide_metabolis1.94482587
21MP0005451_abnormal_body_composition1.81083687
22MP0003195_calcinosis1.79833357
23MP0004233_abnormal_muscle_weight1.79579854
24MP0003950_abnormal_plasma_membrane1.75465510
25MP0005076_abnormal_cell_differentiation1.74761438
26MP0003566_abnormal_cell_adhesion1.72795935
27MP0005083_abnormal_biliary_tract1.68909970
28MP0005409_darkened_coat_color1.68721233
29MP0004858_abnormal_nervous_system1.58134165
30MP0005503_abnormal_tendon_morphology1.56247389
31MP0003283_abnormal_digestive_organ1.53306765
32MP0001944_abnormal_pancreas_morphology1.44104603
33MP0002896_abnormal_bone_mineralization1.40217952
34MP0005023_abnormal_wound_healing1.36118267
35MP0004272_abnormal_basement_membrane1.32882554
36MP0009840_abnormal_foam_cell1.32615441
37MP0000013_abnormal_adipose_tissue1.30832268
38MP0002796_impaired_skin_barrier1.29249086
39MP0000767_abnormal_smooth_muscle1.27333170
40MP0003693_abnormal_embryo_hatching1.25679458
41MP0000537_abnormal_urethra_morphology1.24261103
42MP0003868_abnormal_feces_composition1.23965832
43MP0003123_paternal_imprinting1.23690710
44MP0009384_cardiac_valve_regurgitation1.22941295
45MP0009643_abnormal_urine_homeostasis1.21582863
46MP0010329_abnormal_lipoprotein_level1.20852439
47MP0009053_abnormal_anal_canal1.18997912
48MP0002693_abnormal_pancreas_physiology1.18562359
49MP0010307_abnormal_tumor_latency1.17485938
50MP0003453_abnormal_keratinocyte_physiol1.17323332
51MP0009780_abnormal_chondrocyte_physiolo1.15815538
52MP0005501_abnormal_skin_physiology1.15305688
53MP0001348_abnormal_lacrimal_gland1.12650699
54MP0003111_abnormal_nucleus_morphology1.11886855
55MP0000609_abnormal_liver_physiology1.11059348
56MP0002060_abnormal_skin_morphology1.10297717
57MP0005408_hypopigmentation1.08185773
58MP0000003_abnormal_adipose_tissue1.08051297
59* MP0005621_abnormal_cell_physiology1.07985025
60MP0001542_abnormal_bone_strength1.07835565
61MP0002138_abnormal_hepatobiliary_system1.06070874
62MP0004782_abnormal_surfactant_physiolog1.05087136
63MP0008932_abnormal_embryonic_tissue1.04950247
64MP0004197_abnormal_fetal_growth/weight/1.04407173
65MP0000858_altered_metastatic_potential1.03984984
66MP0003279_aneurysm1.03848573
67MP0001216_abnormal_epidermal_layer1.03520189
68MP0004957_abnormal_blastocyst_morpholog1.02944213
69MP0000627_abnormal_mammary_gland0.99067642
70MP0002009_preneoplasia0.97737334
71MP0000462_abnormal_digestive_system0.97677658
72MP0001730_embryonic_growth_arrest0.97102585
73MP0001299_abnormal_eye_distance/0.94334683
74MP0003448_altered_tumor_morphology0.91494053
75MP0005332_abnormal_amino_acid0.90829036
76MP0003183_abnormal_peptide_metabolism0.90368913
77MP0000598_abnormal_liver_morphology0.90277747
78MP0008875_abnormal_xenobiotic_pharmacok0.89544290
79MP0009672_abnormal_birth_weight0.89269519
80MP0000534_abnormal_ureter_morphology0.89055507
81MP0003385_abnormal_body_wall0.88881266
82MP0003115_abnormal_respiratory_system0.87230799
83MP0001756_abnormal_urination0.86465850
84MP0001881_abnormal_mammary_gland0.86176625
85MP0002086_abnormal_extraembryonic_tissu0.86005111
86MP0002078_abnormal_glucose_homeostasis0.85646595
87MP0008007_abnormal_cellular_replicative0.85464946
88MP0001243_abnormal_dermal_layer0.85223723
89MP0004808_abnormal_hematopoietic_stem0.85123039
90MP0002166_altered_tumor_susceptibility0.84038222
91MP0002006_tumorigenesis0.83856050
92MP0003942_abnormal_urinary_system0.83245487
93MP0002085_abnormal_embryonic_tissue0.82689395
94MP0000762_abnormal_tongue_morphology0.82000032
95MP0004043_abnormal_pH_regulation0.81230653
96MP0001727_abnormal_embryo_implantation0.81148887
97MP0004185_abnormal_adipocyte_glucose0.80953455
98MP0003221_abnormal_cardiomyocyte_apopto0.80798595
99MP0002909_abnormal_adrenal_gland0.80753585
100MP0002088_abnormal_embryonic_growth/wei0.80408590
101MP0000377_abnormal_hair_follicle0.80015048
102* MP0005384_cellular_phenotype0.79852061
103MP0003984_embryonic_growth_retardation0.79261716
104MP0003959_abnormal_lean_body0.79246326
105MP0005375_adipose_tissue_phenotype0.78942202
106MP0001915_intracranial_hemorrhage0.78415066
107MP0001958_emphysema0.78271616
108MP0000428_abnormal_craniofacial_morphol0.77058583
109MP0005319_abnormal_enzyme/_coenzyme0.76545289
110MP0005165_increased_susceptibility_to0.76064762
111MP0002925_abnormal_cardiovascular_devel0.76052080
112MP0001697_abnormal_embryo_size0.75880731
113MP0003795_abnormal_bone_structure0.75629678
114MP0005380_embryogenesis_phenotype0.75587497
115MP0001672_abnormal_embryogenesis/_devel0.75587497
116MP0005248_abnormal_Harderian_gland0.74752026
117MP0008260_abnormal_autophagy0.74531745
118MP0000432_abnormal_head_morphology0.73600944
119MP0005058_abnormal_lysosome_morphology0.73475461
120MP0002084_abnormal_developmental_patter0.73126260
121MP0005187_abnormal_penis_morphology0.72856025
122MP0000350_abnormal_cell_proliferation0.72688533
123MP0001879_abnormal_lymphatic_vessel0.71998653
124MP0002118_abnormal_lipid_homeostasis0.71217622
125MP0001614_abnormal_blood_vessel0.70801907
126MP0001661_extended_life_span0.70693156
127MP0010368_abnormal_lymphatic_system0.70484436
128MP0000613_abnormal_salivary_gland0.70454646
129MP0002928_abnormal_bile_duct0.70441354
130MP0003890_abnormal_embryonic-extraembry0.70245048
131MP0005508_abnormal_skeleton_morphology0.70014743
132MP0002080_prenatal_lethality0.69801458
133MP0009703_decreased_birth_body0.68388528
134MP0003119_abnormal_digestive_system0.68247153
135MP0002168_other_aberrant_phenotype0.66968320
136MP0005666_abnormal_adipose_tissue0.66805098
137MP0000163_abnormal_cartilage_morphology0.64336657
138MP0003077_abnormal_cell_cycle0.63871220
139MP0001849_ear_inflammation0.63169182
140MP0003191_abnormal_cellular_cholesterol0.63000966
141MP0003091_abnormal_cell_migration0.62865206
142MP0000733_abnormal_muscle_development0.62422271
143MP0002115_abnormal_skeleton_extremities0.61788336
144MP0002089_abnormal_postnatal_growth/wei0.61751939

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.04848898
2Protrusio acetabuli (HP:0003179)3.75318394
3Hypoglycemic seizures (HP:0002173)3.47631798
4Hyperinsulinemic hypoglycemia (HP:0000825)3.32131850
5Vascular tortuosity (HP:0004948)3.26011416
6Arterial tortuosity (HP:0005116)3.24913529
7Premature rupture of membranes (HP:0001788)3.15556496
8Asymmetry of the thorax (HP:0001555)3.04066744
9Hyperglycemia (HP:0003074)3.01134433
10Vertebral compression fractures (HP:0002953)3.00265538
11Abnormality of the common coagulation pathway (HP:0010990)2.98979697
12Abnormality of the intrinsic pathway (HP:0010989)2.97808912
13Intrahepatic cholestasis (HP:0001406)2.94799462
14Abnormality of the pancreatic islet cells (HP:0006476)2.83761452
15Abnormality of endocrine pancreas physiology (HP:0012093)2.83761452
16Cervical subluxation (HP:0003308)2.81893163
17Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77868933
18Symptomatic seizures (HP:0011145)2.63301533
19Abnormality of dentin (HP:0010299)2.61597100
20Hyperacusis (HP:0010780)2.60220521
21Spinal rigidity (HP:0003306)2.59553427
22Insidious onset (HP:0003587)2.58569757
23Termporal pattern (HP:0011008)2.58569757
24Ankle contracture (HP:0006466)2.55279780
25Aortic aneurysm (HP:0004942)2.53571774
26Back pain (HP:0003418)2.52624401
27Fragile skin (HP:0001030)2.51984955
28Ankyloglossia (HP:0010296)2.51530607
29Ketoacidosis (HP:0001993)2.49660869
30Cerebral aneurysm (HP:0004944)2.47934581
31Pancreatic islet-cell hyperplasia (HP:0004510)2.46382814
32Short nail (HP:0001799)2.41493815
33Xanthomatosis (HP:0000991)2.41122690
34Abnormal foot bone ossification (HP:0010675)2.40829705
35Abnormality of oral frenula (HP:0000190)2.38844622
36Deep venous thrombosis (HP:0002625)2.38561771
37Upper limb amyotrophy (HP:0009129)2.37971324
38Distal upper limb amyotrophy (HP:0007149)2.37971324
39Thoracolumbar scoliosis (HP:0002944)2.37897566
40Metaphyseal cupping (HP:0003021)2.37102683
41Follicular hyperkeratosis (HP:0007502)2.36920050
42Subacute progressive viral hepatitis (HP:0006572)2.34551351
43Syringomyelia (HP:0003396)2.33500804
44Spinal cord lesions (HP:0100561)2.33500804
45Aneurysm (HP:0002617)2.27527998
46Severe short stature (HP:0003510)2.26857614
47Late onset (HP:0003584)2.20233816
48Aortic dissection (HP:0002647)2.18352222
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16606683
50Abnormal cartilage morphology (HP:0002763)2.14496169
51Insulin-resistant diabetes mellitus (HP:0000831)2.11184621
52Abnormal biliary tract morphology (HP:0012440)2.10706570
53Distal lower limb amyotrophy (HP:0008944)2.10306468
54Genu recurvatum (HP:0002816)2.09455150
55Soft skin (HP:0000977)2.09432782
56Hyperextensible skin (HP:0000974)2.08597803
57Insomnia (HP:0100785)2.08490599
58Ketosis (HP:0001946)2.07417083
59Natal tooth (HP:0000695)2.07067403
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06882811
61Insulin resistance (HP:0000855)2.06719442
62Disproportionate tall stature (HP:0001519)2.06155755
63Conjugated hyperbilirubinemia (HP:0002908)2.05992435
64Hypobetalipoproteinemia (HP:0003563)2.05739380
65Broad face (HP:0000283)2.05630695
66Bladder diverticulum (HP:0000015)2.05050315
67Dilatation of the ascending aorta (HP:0005111)2.04452988
68Elbow flexion contracture (HP:0002987)2.02129296
69Exostoses (HP:0100777)2.00560952
70Atrophic scars (HP:0001075)1.99674000
71Abnormal tarsal ossification (HP:0008369)1.99045261
72Abnormality of the calcaneus (HP:0008364)1.98378392
73Abdominal distention (HP:0003270)1.98354445
74Ulnar bowing (HP:0003031)1.97775559
75Fat malabsorption (HP:0002630)1.97519961
76Nonimmune hydrops fetalis (HP:0001790)1.97467406
77Platyspondyly (HP:0000926)1.97194519
78Joint laxity (HP:0001388)1.96855868
79Achilles tendon contracture (HP:0001771)1.96710679
80Abnormal delivery (HP:0001787)1.96667494
81Epiphyseal dysplasia (HP:0002656)1.96475772
82Rectal prolapse (HP:0002035)1.95812007
83Abnormal pancreas size (HP:0012094)1.94847565
84Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94530279
85Skin nodule (HP:0200036)1.93962554
86Mitral valve prolapse (HP:0001634)1.93846435
87Advanced eruption of teeth (HP:0006288)1.92881638
88Flat acetabular roof (HP:0003180)1.92815150
89Mucopolysacchariduria (HP:0008155)1.92555889
90Urinary glycosaminoglycan excretion (HP:0003541)1.92555889
91Shallow orbits (HP:0000586)1.90135906
92Right ventricular cardiomyopathy (HP:0011663)1.89663763
93Blue sclerae (HP:0000592)1.89590082
94Deep philtrum (HP:0002002)1.89336696
95Increased connective tissue (HP:0009025)1.89213848
96Renal duplication (HP:0000075)1.88432077
97Protuberant abdomen (HP:0001538)1.88292436
98Abnormality of proline metabolism (HP:0010907)1.88028805
99Hydroxyprolinuria (HP:0003080)1.88028805
100Hepatocellular carcinoma (HP:0001402)1.87831859
101Overgrowth (HP:0001548)1.87058431
102Neonatal short-limb short stature (HP:0008921)1.86842576
103Beaking of vertebral bodies (HP:0004568)1.86179246
104Cupped ribs (HP:0000887)1.84733922
105Peritonitis (HP:0002586)1.84645197
106Abnormality of purine metabolism (HP:0004352)1.84633473
107Hand muscle atrophy (HP:0009130)1.84582270
108Mitral regurgitation (HP:0001653)1.84436049
109Abnormality of carpal bone ossification (HP:0006257)1.83086907
110Relative macrocephaly (HP:0004482)1.81749570
111Long palpebral fissure (HP:0000637)1.81674174
112Cortical dysplasia (HP:0002539)1.80541947
113Abnormality of the Achilles tendon (HP:0005109)1.79646440
114Bowel diverticulosis (HP:0005222)1.78921484
115Tetraparesis (HP:0002273)1.77750096
116Orthostatic hypotension (HP:0001278)1.76991807
117Spinal cord compression (HP:0002176)1.76829258
118Wormian bones (HP:0002645)1.76521770
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.76151411
120Epidermoid cyst (HP:0200040)1.76098933
121Abnormality of the acetabulum (HP:0003170)1.75993041
122Breech presentation (HP:0001623)1.75228154
123Cardiovascular calcification (HP:0011915)1.74785047
124Hypolipoproteinemia (HP:0010981)1.74485813
125Deviation of the thumb (HP:0009603)1.74154314
126Thin bony cortex (HP:0002753)1.73260480
127Abnormal ossification of hand bones (HP:0005921)1.72991317
128Mitral stenosis (HP:0001718)1.72490465
129Long toe (HP:0010511)1.71975249
130Sparse lateral eyebrow (HP:0005338)1.71265964
131Unilateral renal agenesis (HP:0000122)1.70574693
132Biliary tract neoplasm (HP:0100574)1.70520958
133Absent frontal sinuses (HP:0002688)1.70307577
134Abnormality of the distal phalanges of the toes (HP:0010182)1.70280786
135Osteolytic defects of the hand bones (HP:0009699)1.68788337
136Osteolytic defects of the phalanges of the hand (HP:0009771)1.68788337
137Trismus (HP:0000211)1.68639155
138Esophageal varix (HP:0002040)1.68578884
139Hyperparathyroidism (HP:0000843)1.68559714
140Spastic diplegia (HP:0001264)1.67798315
141Lower limb amyotrophy (HP:0007210)1.67394561
142Entropion (HP:0000621)1.66675181
143Coxa vara (HP:0002812)1.66621562
144Exocrine pancreatic insufficiency (HP:0001738)1.66482006
145Delayed closure of the anterior fontanelle (HP:0001476)1.65546122
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65366053
147Papillary thyroid carcinoma (HP:0002895)1.65246867
148Hematochezia (HP:0002573)1.64073168
149Enlarged penis (HP:0000040)1.63576059
150Missing ribs (HP:0000921)1.62891622
151Gout (HP:0001997)1.62280556
152Vertebral arch anomaly (HP:0008438)1.62185119
153Ectopia lentis (HP:0001083)1.62012346
154Lymphangioma (HP:0100764)1.61637702
155Hammertoe (HP:0001765)1.61258122
156Mildly elevated creatine phosphokinase (HP:0008180)1.61177824
157Spondylolisthesis (HP:0003302)1.60898590
158Abnormal enzyme/coenzyme activity (HP:0012379)1.60237941
159Micronodular cirrhosis (HP:0001413)1.60110405
160Hepatoblastoma (HP:0002884)1.59447044
161Abnormality of skull ossification (HP:0002703)1.58576133
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.58432957
163Abnormality of the umbilical cord (HP:0010881)1.58416147
164Macroorchidism (HP:0000053)1.58112326
165Abnormality of alkaline phosphatase activity (HP:0004379)1.57299545
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57039956
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57039956
168Biconcave vertebral bodies (HP:0004586)1.56901927
169Persistence of primary teeth (HP:0006335)1.56876781
170Increased variability in muscle fiber diameter (HP:0003557)1.55589128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.17642878
2TRIB33.11858029
3PKN22.98925830
4LATS12.91841386
5PASK2.86033773
6FLT32.81586845
7SCYL22.76082031
8FRK2.74037025
9ICK2.33238173
10PTK62.22874679
11TAOK32.16371835
12SMG12.12583431
13PDGFRA1.99680099
14SIK11.99581857
15BCKDK1.76994128
16STK31.74992058
17RIPK11.73478351
18EEF2K1.71654300
19BRSK21.68506687
20INSRR1.68046863
21KSR21.67604746
22EPHA31.65479630
23EPHA21.63278340
24PRPF4B1.60619955
25FGFR41.56574045
26NEK91.51099268
27YES11.50961990
28NTRK11.46457082
29TESK11.46401832
30STK101.44810100
31LRRK21.41213930
32EIF2AK31.34702431
33MAP3K101.31061728
34DDR21.28838768
35MET1.27906708
36NEK11.24117520
37ERBB41.20614106
38SIK31.19273416
39TSSK61.19159669
40MAP3K31.18759306
41TTN1.18139290
42RPS6KA41.16620277
43KSR11.16148681
44PTK21.15569663
45MAP3K91.13798432
46EIF2AK11.10068842
47PIK3CG1.08722808
48MAP3K21.06617027
49PAK41.06612033
50RPS6KB21.06599359
51CDK121.04975277
52CDK71.04487344
53MYLK1.04278651
54MAP3K81.01890180
55MTOR1.01396066
56TRPM70.98189428
57TGFBR10.97791258
58LMTK20.95725581
59FGFR10.94961003
60MAP3K140.94929881
61JAK30.94911416
62PAK20.94604818
63PBK0.94530272
64FGFR30.94006686
65IRAK30.93738607
66ARAF0.92153187
67CDK60.91447951
68FER0.91080071
69MAP3K130.90168176
70MAP2K30.89744908
71CDC70.86380215
72MOS0.85547217
73CLK10.83889149
74ACVR1B0.82809353
75TTK0.81142635
76STK380.80174673
77BCR0.76017421
78EPHB10.76010425
79MAPK150.75283373
80NUAK10.73809973
81CAMK1G0.70713806
82HIPK20.70104635
83PDGFRB0.66771086
84NEK20.66655407
85TESK20.66555998
86DMPK0.66075298
87SRPK10.66042921
88MAPKAPK30.65847227
89DYRK1B0.63373333
90RAF10.62803201
91BRAF0.61363372
92WNK10.60429310
93BUB10.59708978
94MST1R0.59453440
95WEE10.59258742
96RET0.58679148
97MELK0.58265191
98TAOK20.56062962
99PAK30.56027288
100CAMK1D0.55496515
101JAK10.54879368
102AURKB0.54092152
103ERBB30.53766061
104BRD40.53443340
105JAK20.52655884
106KDR0.52645488
107TYK20.52641162
108MAP3K120.52412893
109ROCK20.51178222
110LATS20.51015088
111PRKD20.50052747
112CDK40.49890056
113PLK30.49715102
114LIMK10.47127733
115PRKCI0.47080448
116MAPK110.46931168
117CDC42BPA0.45169615
118TGFBR20.44808041
119STK38L0.44771509
120IRAK10.44237081
121BRSK10.44176704
122CDK90.44096552
123PRKD30.43613917
124MAP2K20.42848455
125ALK0.42274117
126NEK60.42027784
127MAP2K10.40920227
128ZAP700.40077936
129GSK3A0.39378750
130CDK180.38642041
131MAP3K60.38059802
132STK240.37392639
133AKT20.37132582
134CHUK0.36853343
135PLK40.36841020
136PRKG20.36684795
137ILK0.36124794
138CHEK10.35568047
139CDK150.34598894
140MAP3K10.34460770
141RPS6KA20.34064807
142AKT30.34005026
143ATR0.33891462
144ITK0.33724719

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.47899356
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.16572344
3Protein export_Homo sapiens_hsa030602.83150306
4Selenocompound metabolism_Homo sapiens_hsa004502.75149860
5One carbon pool by folate_Homo sapiens_hsa006702.26436844
6Sulfur metabolism_Homo sapiens_hsa009202.15745414
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96789233
8Fat digestion and absorption_Homo sapiens_hsa049751.87571494
9Nitrogen metabolism_Homo sapiens_hsa009101.87424953
10Tryptophan metabolism_Homo sapiens_hsa003801.78172789
11Fatty acid degradation_Homo sapiens_hsa000711.69361639
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.68044037
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65551378
14N-Glycan biosynthesis_Homo sapiens_hsa005101.58672545
15Folate biosynthesis_Homo sapiens_hsa007901.58362777
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57652305
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54204950
18Protein digestion and absorption_Homo sapiens_hsa049741.50126312
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46787844
20Vibrio cholerae infection_Homo sapiens_hsa051101.44550600
21Non-small cell lung cancer_Homo sapiens_hsa052231.43548017
22Renal cell carcinoma_Homo sapiens_hsa052111.42188066
23Lysine degradation_Homo sapiens_hsa003101.39804754
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31853292
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29326926
26Glioma_Homo sapiens_hsa052141.26429472
27Prion diseases_Homo sapiens_hsa050201.24884148
28Starch and sucrose metabolism_Homo sapiens_hsa005001.24394639
29Shigellosis_Homo sapiens_hsa051311.24161615
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20534114
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20026612
32Other glycan degradation_Homo sapiens_hsa005111.15942254
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.15644926
34Caffeine metabolism_Homo sapiens_hsa002321.14408830
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13885293
36Acute myeloid leukemia_Homo sapiens_hsa052211.13254919
37Renin-angiotensin system_Homo sapiens_hsa046141.08601224
38Arginine biosynthesis_Homo sapiens_hsa002201.07188290
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06542004
40Complement and coagulation cascades_Homo sapiens_hsa046101.06052118
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05882011
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05647237
43Hepatitis B_Homo sapiens_hsa051611.01766501
44ECM-receptor interaction_Homo sapiens_hsa045121.00741377
45Propanoate metabolism_Homo sapiens_hsa006401.00143138
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99616528
47Adherens junction_Homo sapiens_hsa045200.98241379
48Insulin resistance_Homo sapiens_hsa049310.97850744
49Antigen processing and presentation_Homo sapiens_hsa046120.97234708
50ErbB signaling pathway_Homo sapiens_hsa040120.96294230
51Biosynthesis of amino acids_Homo sapiens_hsa012300.95965892
52Fatty acid metabolism_Homo sapiens_hsa012120.95484813
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95404399
54Colorectal cancer_Homo sapiens_hsa052100.95374983
55Galactose metabolism_Homo sapiens_hsa000520.92891388
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92805275
57Legionellosis_Homo sapiens_hsa051340.92361686
58Fructose and mannose metabolism_Homo sapiens_hsa000510.92156979
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92039987
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.91697186
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91641650
62Carbon metabolism_Homo sapiens_hsa012000.91277965
63Tight junction_Homo sapiens_hsa045300.91182463
64Insulin signaling pathway_Homo sapiens_hsa049100.90775438
65Focal adhesion_Homo sapiens_hsa045100.87583451
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85889158
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82676063
68PPAR signaling pathway_Homo sapiens_hsa033200.82461300
69Small cell lung cancer_Homo sapiens_hsa052220.82188452
70Melanoma_Homo sapiens_hsa052180.81860118
71VEGF signaling pathway_Homo sapiens_hsa043700.81640457
72Hepatitis C_Homo sapiens_hsa051600.81377644
73Cell cycle_Homo sapiens_hsa041100.80770486
74Lysosome_Homo sapiens_hsa041420.80023651
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79991674
76Histidine metabolism_Homo sapiens_hsa003400.79565791
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78685587
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78378192
79mRNA surveillance pathway_Homo sapiens_hsa030150.78275917
80Thyroid cancer_Homo sapiens_hsa052160.77178025
81Endocytosis_Homo sapiens_hsa041440.77066240
82Bladder cancer_Homo sapiens_hsa052190.76455568
83Chronic myeloid leukemia_Homo sapiens_hsa052200.75748835
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75101992
85Estrogen signaling pathway_Homo sapiens_hsa049150.74625233
86Apoptosis_Homo sapiens_hsa042100.73795298
87ABC transporters_Homo sapiens_hsa020100.73302675
88RNA transport_Homo sapiens_hsa030130.71442423
89Pathways in cancer_Homo sapiens_hsa052000.71431290
90Proteoglycans in cancer_Homo sapiens_hsa052050.71141614
91p53 signaling pathway_Homo sapiens_hsa041150.69843942
92Butanoate metabolism_Homo sapiens_hsa006500.69615280
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68908659
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.68847900
95Viral carcinogenesis_Homo sapiens_hsa052030.68469468
96Sphingolipid metabolism_Homo sapiens_hsa006000.67972699
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.67840464
98Pyruvate metabolism_Homo sapiens_hsa006200.67366380
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.67277373
100beta-Alanine metabolism_Homo sapiens_hsa004100.66851771
101Phenylalanine metabolism_Homo sapiens_hsa003600.66798051
102Salmonella infection_Homo sapiens_hsa051320.66282331
103MicroRNAs in cancer_Homo sapiens_hsa052060.65778132
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.64544069
105Peroxisome_Homo sapiens_hsa041460.64226713
106HIF-1 signaling pathway_Homo sapiens_hsa040660.63151292
107Steroid biosynthesis_Homo sapiens_hsa001000.60779678
108Vitamin digestion and absorption_Homo sapiens_hsa049770.59983351
109Pentose phosphate pathway_Homo sapiens_hsa000300.59539613
110Bile secretion_Homo sapiens_hsa049760.58938527
111mTOR signaling pathway_Homo sapiens_hsa041500.58873733
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58454226
113Inositol phosphate metabolism_Homo sapiens_hsa005620.58363077
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58100363
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57304083
116Measles_Homo sapiens_hsa051620.56151956
117Arginine and proline metabolism_Homo sapiens_hsa003300.55877655
118Amoebiasis_Homo sapiens_hsa051460.55575840
119AMPK signaling pathway_Homo sapiens_hsa041520.55514836
120HTLV-I infection_Homo sapiens_hsa051660.53520781
121Prostate cancer_Homo sapiens_hsa052150.53293176
122Choline metabolism in cancer_Homo sapiens_hsa052310.52192387
123TNF signaling pathway_Homo sapiens_hsa046680.52130607
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50593194
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49734784
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48659253
127Fatty acid biosynthesis_Homo sapiens_hsa000610.48347560
128Thyroid hormone synthesis_Homo sapiens_hsa049180.48240637
129Type II diabetes mellitus_Homo sapiens_hsa049300.47450870
130Wnt signaling pathway_Homo sapiens_hsa043100.46830833
131Pancreatic cancer_Homo sapiens_hsa052120.46464662
132Glutathione metabolism_Homo sapiens_hsa004800.45849363
133TGF-beta signaling pathway_Homo sapiens_hsa043500.45436308
134Tyrosine metabolism_Homo sapiens_hsa003500.44957777
135Gap junction_Homo sapiens_hsa045400.44453342
136Influenza A_Homo sapiens_hsa051640.43828458
137Hippo signaling pathway_Homo sapiens_hsa043900.43778598
138FoxO signaling pathway_Homo sapiens_hsa040680.43750756
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43389832
140Endometrial cancer_Homo sapiens_hsa052130.43373109
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43285487
142Pancreatic secretion_Homo sapiens_hsa049720.43120308
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.42750015
144Prolactin signaling pathway_Homo sapiens_hsa049170.42438057
145Glycerolipid metabolism_Homo sapiens_hsa005610.41861741
146Toxoplasmosis_Homo sapiens_hsa051450.41653972
147Glucagon signaling pathway_Homo sapiens_hsa049220.40955023
148Chemical carcinogenesis_Homo sapiens_hsa052040.40227365
149Cyanoamino acid metabolism_Homo sapiens_hsa004600.39337410
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39036602

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