AREG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)7.42297203
2cell-substrate junction assembly (GO:0007044)7.41684295
3negative regulation of keratinocyte proliferation (GO:0010839)6.66202829
4negative regulation of B cell proliferation (GO:0030889)5.97040696
5regulation of cytokine secretion involved in immune response (GO:0002739)5.70962959
6interferon-gamma secretion (GO:0072643)5.54705053
7regulation of chemokine secretion (GO:0090196)5.47390298
8hypotonic response (GO:0006971)5.45271455
9surfactant homeostasis (GO:0043129)5.44817975
10branching involved in labyrinthine layer morphogenesis (GO:0060670)5.39647317
11regulation of regulatory T cell differentiation (GO:0045589)5.35769719
12desmosome organization (GO:0002934)5.03213920
13positive regulation of epidermal cell differentiation (GO:0045606)5.00382375
14regulation of transforming growth factor beta2 production (GO:0032909)4.94439083
15regulation of hair follicle development (GO:0051797)4.85016598
16positive regulation of epidermis development (GO:0045684)4.82964742
17chemical homeostasis within a tissue (GO:0048875)4.79589371
18regulation of keratinocyte proliferation (GO:0010837)4.68666268
19positive regulation of chemokine secretion (GO:0090197)4.59118337
20positive regulation of hair follicle development (GO:0051798)4.33629966
21positive regulation of hair cycle (GO:0042635)4.33629966
22intermediate filament organization (GO:0045109)4.24627888
23negative regulation of nitric oxide biosynthetic process (GO:0045019)4.23870268
24negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.19469480
25hair cycle (GO:0042633)4.17841403
26molting cycle (GO:0042303)4.17841403
27mesodermal cell differentiation (GO:0048333)4.14397185
28negative regulation of interleukin-12 production (GO:0032695)4.10008883
29regulation of epidermal growth factor-activated receptor activity (GO:0007176)4.07146763
30positive regulation of keratinocyte differentiation (GO:0045618)4.01961142
31regulation of hair cycle (GO:0042634)4.01082020
32positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.00225093
33regulation of MHC class II biosynthetic process (GO:0045346)3.99529079
34regulation of T cell tolerance induction (GO:0002664)3.99486307
35tolerance induction (GO:0002507)3.94664936
36keratinocyte development (GO:0003334)3.90427030
37negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.90150646
38skin morphogenesis (GO:0043589)3.87587655
39negative regulation of interferon-gamma production (GO:0032689)3.82832123
40regulation of epidermis development (GO:0045682)3.73202605
41epidermis development (GO:0008544)3.72662744
42endodermal cell differentiation (GO:0035987)3.72538546
43regulation of membrane protein ectodomain proteolysis (GO:0051043)3.72402713
44gap junction assembly (GO:0016264)3.70257742
45membrane raft organization (GO:0031579)3.67391140
46regulation of keratinocyte differentiation (GO:0045616)3.67184941
47hepatocyte apoptotic process (GO:0097284)3.65645904
48protein localization to endosome (GO:0036010)3.63719137
49keratinocyte proliferation (GO:0043616)3.63238619
50intestinal epithelial cell development (GO:0060576)3.63208454
51negative regulation of B cell activation (GO:0050869)3.59674810
52negative regulation of T cell proliferation (GO:0042130)3.54581109
53negative regulation of cytokine production involved in immune response (GO:0002719)3.52550109
54positive regulation of tolerance induction (GO:0002645)3.49573257
55keratinization (GO:0031424)3.47205309
56hemidesmosome assembly (GO:0031581)3.44869475
57hepatocyte differentiation (GO:0070365)3.44782175
58negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.42057269
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.40516097
60T-helper cell differentiation (GO:0042093)3.38253373
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.38253373
62response to inactivity (GO:0014854)3.27975323
63renal system development (GO:0072001)3.25233702
64cell adhesion mediated by integrin (GO:0033627)3.22508718
65regulation of metalloenzyme activity (GO:0048552)3.21824234
66negative regulation of chondrocyte differentiation (GO:0032331)3.20893206
67interferon-gamma production (GO:0032609)3.20755573
68positive thymic T cell selection (GO:0045059)3.18488350
69regulation of isotype switching (GO:0045191)3.18230017
70negative regulation of production of molecular mediator of immune response (GO:0002701)3.17337709
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17016257
72regulation of podosome assembly (GO:0071801)3.16918502
73cellular copper ion homeostasis (GO:0006878)3.14734345
74regulation of epidermal cell differentiation (GO:0045604)3.13465426
75regulation of B cell proliferation (GO:0030888)3.12263131
76regulation of water loss via skin (GO:0033561)3.10540084
77regulation of T cell receptor signaling pathway (GO:0050856)3.07325304
78positive regulation of interleukin-8 secretion (GO:2000484)3.06259345
79negative regulation of NF-kappaB import into nucleus (GO:0042347)3.04226852
80regulation of transforming growth factor beta production (GO:0071634)3.04016003
81regulation of vitamin D biosynthetic process (GO:0060556)3.03608858
82regulation of tolerance induction (GO:0002643)3.03170544
83negative regulation of T cell mediated immunity (GO:0002710)2.98867306
84leukocyte aggregation (GO:0070486)2.96981482
85negative regulation of lymphocyte proliferation (GO:0050672)2.96355178
86negative regulation of mononuclear cell proliferation (GO:0032945)2.96355178
87tyrosine phosphorylation of STAT protein (GO:0007260)2.95315649
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95009827
89positive regulation of chemokine biosynthetic process (GO:0045080)2.94745013
90response to muramyl dipeptide (GO:0032495)2.92155783
91negative regulation of leukocyte proliferation (GO:0070664)2.91540619
92regulation of interleukin-13 production (GO:0032656)2.88378874
93regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88349963
94negative regulation of T cell differentiation (GO:0045581)2.87682943
95epidermal cell differentiation (GO:0009913)2.87506372
96growth hormone receptor signaling pathway (GO:0060396)2.86631352
97cell junction assembly (GO:0034329)2.86590757
98regulation of interferon-alpha production (GO:0032647)2.86281090
99alpha-beta T cell differentiation involved in immune response (GO:0002293)2.85221952
100alpha-beta T cell activation involved in immune response (GO:0002287)2.85221952
101T cell differentiation involved in immune response (GO:0002292)2.85221952
102renal filtration (GO:0097205)2.85142321
103regulation of inflammatory response to antigenic stimulus (GO:0002861)2.85083298
104regulation of immunoglobulin production (GO:0002637)2.84443259
105negative regulation of T cell activation (GO:0050868)2.80828112
106thymic T cell selection (GO:0045061)2.80232733
107lung lobe morphogenesis (GO:0060463)2.79759221
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76954977
109skin development (GO:0043588)2.75614872
110ER overload response (GO:0006983)2.74822489
111regulation of transforming growth factor beta1 production (GO:0032908)2.74492018
112negative regulation of interleukin-2 production (GO:0032703)2.74007056
113water homeostasis (GO:0030104)2.73828969
114mammary gland development (GO:0030879)2.73368011
115polarized epithelial cell differentiation (GO:0030859)2.72492376
116bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72359977
117ectoderm development (GO:0007398)2.67445239
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.65770339
119regulation of isotype switching to IgG isotypes (GO:0048302)2.65299924
120regulation of immunoglobulin mediated immune response (GO:0002889)2.64243875
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.64127062
122natural killer cell mediated immunity (GO:0002228)2.63561577
123natural killer cell mediated cytotoxicity (GO:0042267)2.63561577
124* dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62770125
125lymphocyte costimulation (GO:0031294)2.62691528
126G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61733164
127cell junction organization (GO:0034330)2.61461533
128wound healing, spreading of epidermal cells (GO:0035313)2.60890416
129negative regulation of epidermis development (GO:0045683)2.60160502
130regulation of immunoglobulin secretion (GO:0051023)2.58756835
131* epithelial cell proliferation (GO:0050673)2.57359794
132pattern specification involved in kidney development (GO:0061004)2.57263356
133epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57115000
134positive regulation of positive chemotaxis (GO:0050927)2.56660213
135ventricular cardiac muscle cell action potential (GO:0086005)2.54120301
136cell differentiation involved in embryonic placenta development (GO:0060706)2.54014432
137establishment of skin barrier (GO:0061436)2.53377424
138positive T cell selection (GO:0043368)2.53209059
139negative regulation of adaptive immune response (GO:0002820)2.53158503
140regulation of endothelial cell chemotaxis (GO:2001026)2.52972153
141regulation of interleukin-8 secretion (GO:2000482)2.52593986
142negative regulation of T cell receptor signaling pathway (GO:0050860)2.52386992
143T cell mediated immunity (GO:0002456)2.52004611
144establishment of endothelial barrier (GO:0061028)2.51740102
145regulation of B cell mediated immunity (GO:0002712)2.51223316
146intermediate filament cytoskeleton organization (GO:0045104)2.50875525
147positive regulation of astrocyte differentiation (GO:0048711)2.48817548
148activation of Rac GTPase activity (GO:0032863)2.48622894
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48162854
150positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.47061155
151regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.47061155
152cellular response to vitamin D (GO:0071305)2.46103417
153positive regulation of isotype switching (GO:0045830)2.45252550
154negative regulation of cytokine secretion (GO:0050710)2.44854299
155multicellular organismal water homeostasis (GO:0050891)2.44614087
156T cell costimulation (GO:0031295)2.44555443
157regulation of vitamin metabolic process (GO:0030656)2.43576688
158regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.43537435
159wound healing (GO:0042060)2.42679988
160negative regulation of cytokine biosynthetic process (GO:0042036)2.42566212
161decidualization (GO:0046697)2.41616335
162positive regulation of type 2 immune response (GO:0002830)2.41554767
163regulation of positive chemotaxis (GO:0050926)2.40362762
164intermediate filament-based process (GO:0045103)2.39106405
165positive regulation of p38MAPK cascade (GO:1900745)2.38899755
166Golgi transport vesicle coating (GO:0048200)2.37038271
167COPI coating of Golgi vesicle (GO:0048205)2.37038271
168cellular response to growth hormone stimulus (GO:0071378)2.36845532
169positive regulation of immunoglobulin production (GO:0002639)2.36824729
170T cell selection (GO:0045058)2.36471921
171positive regulation of protein export from nucleus (GO:0046827)2.36382492
172copper ion homeostasis (GO:0055070)2.36244580
173keratinocyte differentiation (GO:0030216)2.35178650
174sphingosine metabolic process (GO:0006670)2.34964543
175regulation of integrin activation (GO:0033623)2.34259818
176* mammary gland epithelial cell proliferation (GO:0033598)2.29732894
177extracellular matrix disassembly (GO:0022617)2.29677853
178regulation of transmission of nerve impulse (GO:0051969)2.28429318
179wound healing, spreading of cells (GO:0044319)2.28377329
180regulation of p38MAPK cascade (GO:1900744)2.27513771
181establishment of epithelial cell polarity (GO:0090162)2.27046434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.76616389
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.93431055
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.87914209
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56606025
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.41779498
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74230956
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72919547
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.64450412
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.49284517
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.40225136
11FOXO3_23340844_ChIP-Seq_DLD1_Human2.25333430
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18000601
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18000601
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.17453251
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.15399414
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08698819
17* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06589687
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97695234
19* SOX2_20726797_ChIP-Seq_SW620_Human1.92002814
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88661748
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.85812998
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.84744811
23* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84313145
24RUNX_20019798_ChIP-Seq_JUKART_Human1.80932623
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74520389
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.69822953
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.66923662
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63761430
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62890512
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61867795
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60682483
32GATA4_25053715_ChIP-Seq_YYC3_Human1.57279400
33* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53763079
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.52482577
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49841128
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49602177
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45386000
38GATA6_25053715_ChIP-Seq_YYC3_Human1.44548454
39CJUN_26792858_Chip-Seq_BT549_Human1.42660585
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42635547
41FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42447597
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39779027
43MYB_26560356_Chip-Seq_TH2_Human1.39120326
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.38871564
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.38243738
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37166735
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36781427
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35372947
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34510046
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.33131197
51KLF5_25053715_ChIP-Seq_YYC3_Human1.32473020
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32231000
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32014455
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31721874
55CLOCK_20551151_ChIP-Seq_293T_Human1.30347317
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.27143963
57AR_21909140_ChIP-Seq_LNCAP_Human1.25556033
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.23706312
59ATF3_27146783_Chip-Seq_COLON_Human1.21645507
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20871464
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.20636511
62GATA1_22025678_ChIP-Seq_K562_Human1.18276941
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.17772939
64MAF_26560356_Chip-Seq_TH1_Human1.16925215
65* AHR_22903824_ChIP-Seq_MCF-7_Human1.16810689
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16120879
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14773295
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13911589
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13391362
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12113387
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07759488
72VDR_24787735_ChIP-Seq_THP-1_Human1.06901771
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06670416
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06058023
75TP53_18474530_ChIP-ChIP_U2OS_Human1.03964265
76ZNF263_19887448_ChIP-Seq_K562_Human1.03925523
77TP63_23658742_ChIP-Seq_EP156T_Human1.03879219
78* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02479362
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02253272
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02002447
81TCF7_22412390_ChIP-Seq_EML_Mouse1.01900755
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.00160224
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99267181
84RACK7_27058665_Chip-Seq_MCF-7_Human0.98874881
85* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97656757
86UBF1/2_26484160_Chip-Seq_HMECs_Human0.97156817
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96986938
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96162306
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95288382
90* LXR_22158963_ChIP-Seq_LIVER_Mouse0.94854718
91GATA3_27048872_Chip-Seq_THYMUS_Human0.92214868
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92036740
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91630171
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91590060
95GATA2_19941826_ChIP-Seq_K562_Human0.90841627
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90609323
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90471508
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89690621
99* BRD4_25478319_ChIP-Seq_HGPS_Human0.89406350
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.88914127
101MYB_26560356_Chip-Seq_TH1_Human0.88741675
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88384853
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88321531
104PU_27001747_Chip-Seq_BMDM_Mouse0.87632736
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86569073
106TP63_22573176_ChIP-Seq_HFKS_Human0.86305897
107EGR1_19032775_ChIP-ChIP_M12_Human0.86053887
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83258051
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82981088
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82545888
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81873176
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80847141
113* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80768731
114* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80768731
115* RXR_22108803_ChIP-Seq_LS180_Human0.80758879
116TP53_22127205_ChIP-Seq_IMR90_Human0.80713611
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79990702
118* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79928744
119UTX_26944678_Chip-Seq_JUKART_Human0.78278460
120TP53_16413492_ChIP-PET_HCT116_Human0.78067037
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76278165
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76203039
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75943687
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73754309
125ELF5_23300383_ChIP-Seq_T47D_Human0.72684074
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70888314
127MYC_18555785_ChIP-Seq_MESCs_Mouse0.69972709
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69461735
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.66855574
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66115306
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.65249349
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.65249349
133VDR_24763502_ChIP-Seq_THP-1_Human0.63960023
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.63457759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer4.65915253
2MP0003303_peritoneal_inflammation4.33278154
3MP0001873_stomach_inflammation3.81266783
4MP0000762_abnormal_tongue_morphology3.54716417
5MP0010234_abnormal_vibrissa_follicle3.26908297
6MP0000467_abnormal_esophagus_morphology3.03401152
7MP0004782_abnormal_surfactant_physiolog2.97195987
8MP0002796_impaired_skin_barrier2.90250225
9MP0003724_increased_susceptibility_to2.72282096
10MP0002234_abnormal_pharynx_morphology2.70308623
11MP0001853_heart_inflammation2.61365127
12MP0008004_abnormal_stomach_pH2.51066890
13MP0003453_abnormal_keratinocyte_physiol2.42017112
14* MP0004947_skin_inflammation2.35929202
15MP0004272_abnormal_basement_membrane2.35120638
16MP0001849_ear_inflammation2.20724104
17MP0005671_abnormal_response_to2.10032464
18MP0005409_darkened_coat_color2.07408353
19MP0003436_decreased_susceptibility_to2.00779692
20MP0005501_abnormal_skin_physiology1.98563408
21MP0010352_gastrointestinal_tract_polyps1.97577910
22MP0003763_abnormal_thymus_physiology1.94734454
23MP0005310_abnormal_salivary_gland1.92099590
24MP0005387_immune_system_phenotype1.90115531
25MP0001790_abnormal_immune_system1.90115531
26MP0010155_abnormal_intestine_physiology1.89647933
27MP0001216_abnormal_epidermal_layer1.89637835
28MP0009785_altered_susceptibility_to1.86673292
29MP0002009_preneoplasia1.82380120
30MP0005000_abnormal_immune_tolerance1.72793816
31MP0002933_joint_inflammation1.67617149
32MP0002148_abnormal_hypersensitivity_rea1.65162187
33MP0005023_abnormal_wound_healing1.64949550
34MP0002006_tumorigenesis1.64755890
35MP0003566_abnormal_cell_adhesion1.63910954
36MP0000678_abnormal_parathyroid_gland1.63337865
37MP0005025_abnormal_response_to1.61548016
38MP0002060_abnormal_skin_morphology1.61237355
39MP0010678_abnormal_skin_adnexa1.61155872
40MP0001835_abnormal_antigen_presentation1.60001681
41MP0009053_abnormal_anal_canal1.59027470
42MP0002405_respiratory_system_inflammati1.58379175
43MP0006082_CNS_inflammation1.55770478
44MP0000537_abnormal_urethra_morphology1.54023328
45MP0000383_abnormal_hair_follicle1.53090633
46MP0002254_reproductive_system_inflammat1.52190617
47MP0003191_abnormal_cellular_cholesterol1.50592646
48MP0001663_abnormal_digestive_system1.50429449
49* MP0002098_abnormal_vibrissa_morphology1.49244837
50MP0002877_abnormal_melanocyte_morpholog1.47103180
51MP0004264_abnormal_extraembryonic_tissu1.45775397
52MP0003315_abnormal_perineum_morphology1.45599411
53MP0001533_abnormal_skeleton_physiology1.45479511
54* MP0000627_abnormal_mammary_gland1.42506100
55MP0003806_abnormal_nucleotide_metabolis1.42394175
56* MP0009931_abnormal_skin_appearance1.40094897
57MP0001542_abnormal_bone_strength1.36316206
58MP0001800_abnormal_humoral_immune1.36211144
59MP0003941_abnormal_skin_development1.35204291
60MP0001851_eye_inflammation1.32802731
61MP0003866_abnormal_defecation1.31352669
62MP0008260_abnormal_autophagy1.30689159
63MP0005076_abnormal_cell_differentiation1.30114694
64MP0005257_abnormal_intraocular_pressure1.29811986
65MP0002166_altered_tumor_susceptibility1.27503916
66MP0002723_abnormal_immune_serum1.26980894
67MP0003448_altered_tumor_morphology1.24340413
68MP0005360_urolithiasis1.23431376
69MP0002452_abnormal_antigen_presenting1.23296266
70MP0000465_gastrointestinal_hemorrhage1.21867903
71MP0008995_early_reproductive_senescence1.20515667
72MP0010771_integument_phenotype1.17752543
73MP0003828_pulmonary_edema1.17295453
74MP0001666_abnormal_nutrient_absorption1.17011931
75MP0000858_altered_metastatic_potential1.16364665
76MP0005275_abnormal_skin_tensile1.16285353
77MP0005381_digestive/alimentary_phenotyp1.14868961
78MP0000427_abnormal_hair_cycle1.14404065
79MP0004185_abnormal_adipocyte_glucose1.13212845
80MP0001845_abnormal_inflammatory_respons1.12019774
81MP0004381_abnormal_hair_follicle1.11995437
82MP0000566_synostosis1.10942081
83MP0001819_abnormal_immune_cell1.08821913
84MP0003705_abnormal_hypodermis_morpholog1.06893842
85MP0003075_altered_response_to1.05972597
86MP0005166_decreased_susceptibility_to1.04581095
87MP0005165_increased_susceptibility_to1.03704675
88* MP0001881_abnormal_mammary_gland1.03702850
89MP0005164_abnormal_response_to1.03101692
90MP0002420_abnormal_adaptive_immunity1.03019196
91MP0001348_abnormal_lacrimal_gland1.02888622
92MP0002277_abnormal_respiratory_mucosa1.01926088
93MP0001191_abnormal_skin_condition1.00990793
94MP0002419_abnormal_innate_immunity0.98843083
95MP0009764_decreased_sensitivity_to0.98075920
96MP0001958_emphysema0.97967835
97* MP0000490_abnormal_crypts_of0.97516357
98MP0000377_abnormal_hair_follicle0.97329232
99MP0000343_altered_response_to0.97254879
100MP0000249_abnormal_blood_vessel0.94319541
101* MP0000367_abnormal_coat/_hair0.93748077
102MP0000685_abnormal_immune_system0.92003674
103MP0004510_myositis0.90677249
104MP0002998_abnormal_bone_remodeling0.88674413
105MP0004883_abnormal_blood_vessel0.88523851
106MP0003045_fibrosis0.88022986
107MP0001177_atelectasis0.87182117
108MP0003950_abnormal_plasma_membrane0.86680577
109MP0000647_abnormal_sebaceous_gland0.86059313
110MP0002282_abnormal_trachea_morphology0.84387010
111MP0002133_abnormal_respiratory_system0.83748630
112MP0005388_respiratory_system_phenotype0.83748630
113MP0001346_abnormal_lacrimal_gland0.81987798
114MP0001243_abnormal_dermal_layer0.81649157
115* MP0000477_abnormal_intestine_morphology0.81130617
116MP0005167_abnormal_blood-brain_barrier0.79566599
117MP0001919_abnormal_reproductive_system0.79043242
118MP0006054_spinal_hemorrhage0.78665919
119MP0002896_abnormal_bone_mineralization0.78226414
120MP0003091_abnormal_cell_migration0.77983927
121MP0005083_abnormal_biliary_tract0.77321272
122MP0000579_abnormal_nail_morphology0.76816046
123MP0008961_abnormal_basal_metabolism0.75956506
124MP0009840_abnormal_foam_cell0.75118099
125MP0003786_premature_aging0.70613185
126MP0002396_abnormal_hematopoietic_system0.69406995
127MP0004019_abnormal_vitamin_homeostasis0.65299666
128MP0001727_abnormal_embryo_implantation0.63783753
129MP0005666_abnormal_adipose_tissue0.63329456
130MP0000013_abnormal_adipose_tissue0.62584263
131MP0005621_abnormal_cell_physiology0.62259788
132MP0009780_abnormal_chondrocyte_physiolo0.60299985
133MP0003183_abnormal_peptide_metabolism0.59317170
134MP0000538_abnormal_urinary_bladder0.57746626
135MP0002177_abnormal_outer_ear0.57618863
136MP0001765_abnormal_ion_homeostasis0.57126817
137MP0002089_abnormal_postnatal_growth/wei0.55722617
138MP0005375_adipose_tissue_phenotype0.55704700
139MP0000470_abnormal_stomach_morphology0.55608367
140MP0003755_abnormal_palate_morphology0.53574783
141* MP0001340_abnormal_eyelid_morphology0.52962752
142MP0005451_abnormal_body_composition0.52345162
143MP0004957_abnormal_blastocyst_morpholog0.50891453
144MP0003943_abnormal_hepatobiliary_system0.49959863
145MP0000733_abnormal_muscle_development0.49567197
146MP0004808_abnormal_hematopoietic_stem0.49223294
147MP0005397_hematopoietic_system_phenotyp0.49032798
148MP0001545_abnormal_hematopoietic_system0.49032798
149MP0010307_abnormal_tumor_latency0.46157556
150* MP0005193_abnormal_anterior_eye0.45226937

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)7.40591306
2Optic neuritis (HP:0100653)7.40591306
3Abnormality of nail color (HP:0100643)7.04987472
4Orchitis (HP:0100796)6.96675179
5Interstitial pulmonary disease (HP:0006530)5.89945010
6Myositis (HP:0100614)5.74856257
7Alopecia of scalp (HP:0002293)5.65687095
8Ridged nail (HP:0001807)5.17528150
9Gangrene (HP:0100758)5.05186083
10Pili torti (HP:0003777)5.04898166
11Pulmonary infiltrates (HP:0002113)4.65464846
12Ureteral stenosis (HP:0000071)4.56592826
13Keratoconjunctivitis sicca (HP:0001097)4.45724471
14Autoimmune hemolytic anemia (HP:0001890)4.42344026
15Ureteral obstruction (HP:0006000)4.30588278
16Abnormality of the prostate (HP:0008775)4.13658424
17Abnormal hair laboratory examination (HP:0003328)4.01932271
18Keratoconjunctivitis (HP:0001096)4.01509118
19Stomatitis (HP:0010280)3.99435706
20Arterial thrombosis (HP:0004420)3.97687940
21Fragile skin (HP:0001030)3.95330707
22Hemoptysis (HP:0002105)3.93497064
23Abnormality of the pericardium (HP:0001697)3.81842686
24Pulmonary embolism (HP:0002204)3.77542246
25Vasculitis (HP:0002633)3.73781286
26Right ventricular cardiomyopathy (HP:0011663)3.69794435
27Pterygium (HP:0001059)3.60760469
28Sparse scalp hair (HP:0002209)3.42147636
29Glomerulopathy (HP:0100820)3.39526375
30Onycholysis (HP:0001806)3.35014341
31Ankyloglossia (HP:0010296)3.31916239
32Selective tooth agenesis (HP:0001592)3.28086999
33Abnormality of placental membranes (HP:0011409)3.25701038
34Amniotic constriction ring (HP:0009775)3.25701038
35Sparse eyelashes (HP:0000653)3.19765853
36Chest pain (HP:0100749)3.15140938
37Natal tooth (HP:0000695)3.04446876
38Obstructive lung disease (HP:0006536)3.02064544
39Chronic obstructive pulmonary disease (HP:0006510)3.02064544
40Parakeratosis (HP:0001036)2.97417311
41Polyneuropathy (HP:0001271)2.95605221
42Elevated erythrocyte sedimentation rate (HP:0003565)2.92949854
43Thrombophlebitis (HP:0004418)2.91779701
44Milia (HP:0001056)2.89443677
45Plantar hyperkeratosis (HP:0007556)2.89193924
46Eczematoid dermatitis (HP:0000976)2.82893588
47Abnormality of oral frenula (HP:0000190)2.78672209
48Anorexia (HP:0002039)2.76145987
49Dry hair (HP:0011359)2.73056613
50Oral leukoplakia (HP:0002745)2.67419788
51Fatigable weakness (HP:0003473)2.64717942
52Abnormality of the neuromuscular junction (HP:0003398)2.64717942
53Abnormality of the pleura (HP:0002103)2.59222035
54Hypodontia (HP:0000668)2.56383007
55Gastrointestinal infarctions (HP:0005244)2.55447306
56Fragile nails (HP:0001808)2.54738976
57Anonychia (HP:0001798)2.54161648
58Carious teeth (HP:0000670)2.52692874
59Pustule (HP:0200039)2.49744200
60Abnormal blistering of the skin (HP:0008066)2.49363450
61Woolly hair (HP:0002224)2.46650910
62Lip pit (HP:0100267)2.46223024
63Ectropion (HP:0000656)2.41110460
64Pancreatitis (HP:0001733)2.38243826
65Hyperhidrosis (HP:0000975)2.37580104
66Popliteal pterygium (HP:0009756)2.37068323
67Meningitis (HP:0001287)2.35268135
68Abnormality of the gastric mucosa (HP:0004295)2.35102572
69Anhidrosis (HP:0000970)2.34783640
70Abnormality of male internal genitalia (HP:0000022)2.32288830
71Osteolytic defects of the hand bones (HP:0009699)2.32007257
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.32007257
73Erythema (HP:0010783)2.31045178
74Cheilitis (HP:0100825)2.30560251
75Periodontitis (HP:0000704)2.29827171
76Autoimmune thrombocytopenia (HP:0001973)2.29588937
77Advanced eruption of teeth (HP:0006288)2.28247697
78Restrictive lung disease (HP:0002091)2.25907475
79Xerostomia (HP:0000217)2.23140208
80Subacute progressive viral hepatitis (HP:0006572)2.21471898
81Atrophic scars (HP:0001075)2.17335523
82Abnormality of the nasal septum (HP:0000419)2.15522076
83Short nail (HP:0001799)2.15108860
84Acne (HP:0001061)2.15054382
85Micronodular cirrhosis (HP:0001413)2.13712934
86Palmoplantar hyperkeratosis (HP:0000972)2.13373269
87Death in infancy (HP:0001522)2.10411485
88Hoarse voice (HP:0001609)2.09475428
89Dehydration (HP:0001944)2.06904836
90Blepharitis (HP:0000498)2.04140782
91Trismus (HP:0000211)2.03962620
92Neurofibrillary tangles (HP:0002185)2.02556904
93Amelogenesis imperfecta (HP:0000705)2.02237380
94Ileus (HP:0002595)2.01279985
95Vertebral arch anomaly (HP:0008438)2.01213233
96Severe combined immunodeficiency (HP:0004430)2.00556472
97Premature loss of primary teeth (HP:0006323)1.99378182
98Abnormality of the fingernails (HP:0001231)1.98795328
99Abnormal hemoglobin (HP:0011902)1.98767127
100Palmar hyperkeratosis (HP:0010765)1.98678052
101Poikiloderma (HP:0001029)1.97754195
102Broad face (HP:0000283)1.97542759
103Encephalitis (HP:0002383)1.97174935
104Congenital ichthyosiform erythroderma (HP:0007431)1.96818088
105Esophageal varix (HP:0002040)1.96474845
106Paresthesia (HP:0003401)1.95882513
107Thick nail (HP:0001805)1.95676054
108Hyperactive renin-angiotensin system (HP:0000841)1.95506703
109Follicular hyperkeratosis (HP:0007502)1.94697376
110Increased IgE level (HP:0003212)1.93774083
111Hypoplasia of dental enamel (HP:0006297)1.92461226
112Mediastinal lymphadenopathy (HP:0100721)1.92400228
113Stomach cancer (HP:0012126)1.87259424
114Septate vagina (HP:0001153)1.86559575
115Oligodontia (HP:0000677)1.86214518
116Corneal erosion (HP:0200020)1.86020060
117Absent eyelashes (HP:0000561)1.85433210
118Cerebral ischemia (HP:0002637)1.83762809
119Palmoplantar keratoderma (HP:0000982)1.83337591
120Abnormality of chloride homeostasis (HP:0011422)1.82684701
121Hypotrichosis (HP:0001006)1.81989092
122Stenosis of the external auditory canal (HP:0000402)1.81654512
123Pulmonary fibrosis (HP:0002206)1.81419192
124Skin ulcer (HP:0200042)1.81344132
125Tubulointerstitial fibrosis (HP:0005576)1.79924942
126Aseptic necrosis (HP:0010885)1.79068532
127Abnormality of the distal phalanges of the toes (HP:0010182)1.78946707
128Deviation of the thumb (HP:0009603)1.77909284
129Congenital, generalized hypertrichosis (HP:0004540)1.77108150
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76642331
131IgM deficiency (HP:0002850)1.74913125
132Fatigue (HP:0012378)1.74680068
133Arthralgia (HP:0002829)1.74653559
134Rectal prolapse (HP:0002035)1.74313578
135Vascular calcification (HP:0004934)1.73266966
136Epistaxis (HP:0000421)1.73259170
137Keratitis (HP:0000491)1.73152875
138Abnormality of the salivary glands (HP:0010286)1.71458065
139Esophageal atresia (HP:0002032)1.70705691
140Myocardial infarction (HP:0001658)1.69914485
141Increased mean platelet volume (HP:0011877)1.69796904
142Hypoplastic labia majora (HP:0000059)1.68463317
143Peritonitis (HP:0002586)1.68259644
144Epidermoid cyst (HP:0200040)1.67811890
145Ureteral duplication (HP:0000073)1.67197635
146Aplasia cutis congenita (HP:0001057)1.66751157
147Combined immunodeficiency (HP:0005387)1.66590332
148Abnormality of secondary sexual hair (HP:0009888)1.66306206
149Abnormality of the axillary hair (HP:0100134)1.66306206
150Gingival bleeding (HP:0000225)1.65164614
151Vertigo (HP:0002321)1.65125289
152Corneal dystrophy (HP:0001131)1.63363064
153Laryngomalacia (HP:0001601)1.63201749
154Flat acetabular roof (HP:0003180)1.62960500
155Hematuria (HP:0000790)1.62871564
156Abnormality of the labia majora (HP:0012881)1.61873871
157Nail dystrophy (HP:0008404)1.61559047
158Respiratory distress (HP:0002098)1.61068583
159Acanthosis nigricans (HP:0000956)1.59516980
160Neonatal respiratory distress (HP:0002643)1.58268948
161Abnormal platelet volume (HP:0011876)1.56768049
162Abnormalities of placenta or umbilical cord (HP:0001194)1.54083475
163Squamous cell carcinoma (HP:0002860)1.51696474
164Cerebral inclusion bodies (HP:0100314)1.51354633
165Curly hair (HP:0002212)1.51037556
166Tibial bowing (HP:0002982)1.50353395
167Polygenic inheritance (HP:0010982)1.49411952
168Multifactorial inheritance (HP:0001426)1.49054263
16911 pairs of ribs (HP:0000878)1.47764881
170Cervical subluxation (HP:0003308)1.46718897
171Abnormality of the alveolar ridges (HP:0006477)1.41280525
172Ventricular tachycardia (HP:0004756)1.38162603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.37668636
2EPHA24.61908439
3MST43.68165190
4ARAF3.21186186
5MST1R2.93760547
6SIK12.81991174
7MAP3K142.32731879
8STK101.98339892
9MAP3K31.94058373
10FLT31.91580054
11NME21.87261123
12NTRK11.79754772
13LRRK21.70897586
14TBK11.66358782
15ZAP701.65251900
16ITK1.64974864
17EPHB11.64268232
18EPHB21.56764832
19STK241.43755887
20RIPK11.40488298
21MAP3K91.39792131
22WNK41.37571195
23CDK61.37354269
24CHUK1.37058180
25EPHA31.33761389
26MAP4K11.32552381
27MAP3K21.29286543
28FER1.28304306
29SCYL21.28047316
30FGFR41.27268384
31BMPR21.26907330
32CSF1R1.24913781
33IKBKE1.24302559
34TAOK11.22292664
35FGFR21.21224539
36IKBKB1.18182852
37JAK31.16866503
38PDGFRA1.15749169
39JAK11.15233575
40LATS21.12147443
41PTK61.11928704
42TGFBR11.11666042
43JAK21.07915459
44TEC1.06854274
45CDK31.05611128
46EIF2AK31.05527274
47PIM21.02352213
48FGFR31.02102202
49BMX1.01541107
50TESK10.98415938
51LATS10.96909911
52LMTK20.96070968
53NEK90.92946329
54TGFBR20.91439722
55PBK0.91294694
56PDGFRB0.89061113
57FRK0.88492943
58BRAF0.86849746
59ERN10.86469422
60WNK10.85570657
61PRPF4B0.85274120
62RPS6KB20.84954900
63EIF2AK20.83856724
64TRPM70.80374842
65PRKCI0.78179091
66LCK0.75407406
67MET0.75370644
68TAOK30.75139728
69MAP3K110.73663954
70NUAK10.72552514
71BLK0.70722944
72MAPK150.68283792
73MAP2K20.68129148
74PTK20.67618917
75HCK0.66749234
76CSK0.66105663
77TRIB30.64653708
78NEK60.62980972
79GSK3A0.62891020
80STK38L0.62443510
81DYRK1B0.61880850
82ABL20.61175635
83PRKCQ0.61111409
84DMPK0.60726916
85RPS6KA40.60290103
86MOS0.59964978
87PRKG20.59748012
88IRAK30.59525410
89MAP3K70.59146890
90KSR20.57755773
91TYK20.57098816
92RAF10.55408640
93BTK0.54274351
94PRKCE0.53731757
95RPS6KA20.52097948
96CDK120.52094208
97ERBB30.50635874
98MAP3K120.50525598
99FYN0.49867562
100STK30.49239948
101SIK30.49170403
102BRD40.48887083
103MAP3K10.47588749
104PAK40.47220321
105CDK90.47063583
106MAP3K100.47015046
107PIM10.46333782
108MAP2K30.46254151
109ROCK20.46060978
110MATK0.45965029
111MAPKAPK20.45841919
112BCR0.45444906
113MAPKAPK30.45430139
114MAP3K130.44103109
115FGFR10.41466940
116ERBB20.40025093
117ABL10.39825037
118SYK0.39684208
119IGF1R0.39368806
120TESK20.39212547
121RPS6KL10.38774320
122RPS6KC10.38774320
123MTOR0.38383669
124STK390.37312011
125SMG10.36963859
126RPS6KA10.36527462
127MAP3K80.36457421
128MAP2K60.35349407
129ERBB40.33625792
130MAP3K60.33133315
131HIPK20.32806752
132TAOK20.32680038
133EGFR0.32160754
134EIF2AK10.31771520
135INSR0.30998278
136MUSK0.27743556
137ILK0.27731557
138DAPK20.27362099
139DDR20.25413583
140RPS6KA60.25411490
141PIK3CG0.25084326
142CSNK1D0.24553656
143GRK60.22952239
144TYRO30.22743564
145PRKCD0.20810764
146PRKD20.20780392

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.63748014
2Asthma_Homo sapiens_hsa053104.46696540
3Allograft rejection_Homo sapiens_hsa053304.05606243
4Graft-versus-host disease_Homo sapiens_hsa053323.52944950
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.14703578
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.95101108
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.51032860
8Leishmaniasis_Homo sapiens_hsa051402.44401763
9T cell receptor signaling pathway_Homo sapiens_hsa046602.34851806
10Hematopoietic cell lineage_Homo sapiens_hsa046402.23594000
11Other glycan degradation_Homo sapiens_hsa005111.86804026
12Malaria_Homo sapiens_hsa051441.85841295
13African trypanosomiasis_Homo sapiens_hsa051431.78040279
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74803825
15p53 signaling pathway_Homo sapiens_hsa041151.71156604
16Mineral absorption_Homo sapiens_hsa049781.55474318
17Toxoplasmosis_Homo sapiens_hsa051451.54067275
18Primary immunodeficiency_Homo sapiens_hsa053401.44823072
19Antigen processing and presentation_Homo sapiens_hsa046121.44772295
20Pertussis_Homo sapiens_hsa051331.43377223
21* ErbB signaling pathway_Homo sapiens_hsa040121.40630177
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.39980979
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38805721
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.38417928
25Steroid biosynthesis_Homo sapiens_hsa001001.38246739
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36286391
27Measles_Homo sapiens_hsa051621.35617895
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.34921038
29Staphylococcus aureus infection_Homo sapiens_hsa051501.33821530
30Osteoclast differentiation_Homo sapiens_hsa043801.32706640
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31614486
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.30691244
33TNF signaling pathway_Homo sapiens_hsa046681.30501114
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30476427
35Rheumatoid arthritis_Homo sapiens_hsa053231.28600100
36Bladder cancer_Homo sapiens_hsa052191.19859513
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18611330
38Adherens junction_Homo sapiens_hsa045201.10483164
39Amoebiasis_Homo sapiens_hsa051461.08816340
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06911375
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04978896
42N-Glycan biosynthesis_Homo sapiens_hsa005101.04540123
43Small cell lung cancer_Homo sapiens_hsa052221.01651663
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.01348543
45Prion diseases_Homo sapiens_hsa050200.98001562
46Salmonella infection_Homo sapiens_hsa051320.97737828
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97258520
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96996410
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95677567
50ECM-receptor interaction_Homo sapiens_hsa045120.95562627
51Tuberculosis_Homo sapiens_hsa051520.94992232
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94781543
53Legionellosis_Homo sapiens_hsa051340.94546582
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94382380
55Sphingolipid metabolism_Homo sapiens_hsa006000.89058267
56Apoptosis_Homo sapiens_hsa042100.87563965
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86604247
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86265363
59Fat digestion and absorption_Homo sapiens_hsa049750.85712596
60Caffeine metabolism_Homo sapiens_hsa002320.83739797
61Hepatitis C_Homo sapiens_hsa051600.83450808
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82654147
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80010759
64Proteoglycans in cancer_Homo sapiens_hsa052050.79696497
65Shigellosis_Homo sapiens_hsa051310.79559013
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78989173
67Galactose metabolism_Homo sapiens_hsa000520.78916166
68Tight junction_Homo sapiens_hsa045300.78010488
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76966155
70Renin-angiotensin system_Homo sapiens_hsa046140.76392884
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74387273
72Influenza A_Homo sapiens_hsa051640.74055613
73Endocytosis_Homo sapiens_hsa041440.73039437
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71684863
75Platelet activation_Homo sapiens_hsa046110.70889913
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70520445
77Notch signaling pathway_Homo sapiens_hsa043300.69073270
78Inositol phosphate metabolism_Homo sapiens_hsa005620.67806665
79Pancreatic cancer_Homo sapiens_hsa052120.67000266
80Dilated cardiomyopathy_Homo sapiens_hsa054140.66523764
81Non-small cell lung cancer_Homo sapiens_hsa052230.65328125
82Axon guidance_Homo sapiens_hsa043600.64096572
83Prolactin signaling pathway_Homo sapiens_hsa049170.63525339
84Viral myocarditis_Homo sapiens_hsa054160.62339335
85Insulin signaling pathway_Homo sapiens_hsa049100.60671417
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60513401
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60457635
88Prostate cancer_Homo sapiens_hsa052150.60234355
89Chemokine signaling pathway_Homo sapiens_hsa040620.57842965
90Histidine metabolism_Homo sapiens_hsa003400.57065573
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56058501
92Hepatitis B_Homo sapiens_hsa051610.54174816
93MicroRNAs in cancer_Homo sapiens_hsa052060.52865591
94FoxO signaling pathway_Homo sapiens_hsa040680.50093236
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50086255
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49852915
97Type I diabetes mellitus_Homo sapiens_hsa049400.49221563
98Focal adhesion_Homo sapiens_hsa045100.48865587
99Lysosome_Homo sapiens_hsa041420.48533298
100Melanoma_Homo sapiens_hsa052180.47645519
101Glioma_Homo sapiens_hsa052140.47020313
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.46779869
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46674146
104Vitamin digestion and absorption_Homo sapiens_hsa049770.45975421
105Insulin resistance_Homo sapiens_hsa049310.45798301
106B cell receptor signaling pathway_Homo sapiens_hsa046620.45627193
107VEGF signaling pathway_Homo sapiens_hsa043700.45127425
108HTLV-I infection_Homo sapiens_hsa051660.43970103
109Acute myeloid leukemia_Homo sapiens_hsa052210.43310662
110Renal cell carcinoma_Homo sapiens_hsa052110.40717568
111Fatty acid biosynthesis_Homo sapiens_hsa000610.40551848
112GnRH signaling pathway_Homo sapiens_hsa049120.40532946
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40292767
114Phagosome_Homo sapiens_hsa041450.40236950
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39431729
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39352619
117Viral carcinogenesis_Homo sapiens_hsa052030.38666936
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.38212344
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38111671
120Rap1 signaling pathway_Homo sapiens_hsa040150.37162952
121HIF-1 signaling pathway_Homo sapiens_hsa040660.36973766
122Nucleotide excision repair_Homo sapiens_hsa034200.36668442
123Chemical carcinogenesis_Homo sapiens_hsa052040.36006086
124* Hippo signaling pathway_Homo sapiens_hsa043900.34161856
125Sulfur metabolism_Homo sapiens_hsa009200.33250055
126TGF-beta signaling pathway_Homo sapiens_hsa043500.32577374
127Herpes simplex infection_Homo sapiens_hsa051680.28563779
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28183860
129Dorso-ventral axis formation_Homo sapiens_hsa043200.28179301
130Pathways in cancer_Homo sapiens_hsa052000.28029335
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27994969
132Thyroid cancer_Homo sapiens_hsa052160.27111233
133Endometrial cancer_Homo sapiens_hsa052130.26969876
134Vibrio cholerae infection_Homo sapiens_hsa051100.26476756

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