AREL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08528370
2locomotory exploration behavior (GO:0035641)5.06664063
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05741679
4synaptic vesicle maturation (GO:0016188)4.83320253
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50280512
6vocalization behavior (GO:0071625)4.47536857
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35734385
8regulation of synapse structural plasticity (GO:0051823)4.34172761
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30466612
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.30466612
11modulation by symbiont of host immune response (GO:0052553)4.30466612
12positive regulation by symbiont of host defense response (GO:0052509)4.30466612
13modulation by symbiont of host defense response (GO:0052031)4.30466612
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30466612
15regulation of glutamate receptor signaling pathway (GO:1900449)4.30096944
16synaptic vesicle exocytosis (GO:0016079)4.19713643
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.15180618
18neurotransmitter-gated ion channel clustering (GO:0072578)4.13602219
19protein localization to endosome (GO:0036010)4.07811332
20regulation of synaptic vesicle exocytosis (GO:2000300)3.99204168
21glutamate secretion (GO:0014047)3.97455335
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.95002956
23layer formation in cerebral cortex (GO:0021819)3.91523606
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87897121
25positive regulation of gamma-delta T cell activation (GO:0046645)3.85665106
26regulation of neuronal synaptic plasticity (GO:0048168)3.85272407
27prepulse inhibition (GO:0060134)3.81938398
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81200316
29negative regulation of cell killing (GO:0031342)3.81132967
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81132967
31protein localization to synapse (GO:0035418)3.77572486
32detection of molecule of bacterial origin (GO:0032490)3.71971373
33neurotransmitter secretion (GO:0007269)3.69236471
34regulation of dendritic spine morphogenesis (GO:0061001)3.68327665
35exploration behavior (GO:0035640)3.67284828
36G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65524041
37activation of protein kinase A activity (GO:0034199)3.62005679
38regulation of synaptic vesicle transport (GO:1902803)3.58430922
39gamma-aminobutyric acid transport (GO:0015812)3.57051600
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56972149
41negative regulation of erythrocyte differentiation (GO:0045647)3.55802476
42synaptic transmission, glutamatergic (GO:0035249)3.51391967
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50747717
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48568526
45neuron-neuron synaptic transmission (GO:0007270)3.43638907
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40953344
47long-term memory (GO:0007616)3.39887779
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39458099
49glutamate receptor signaling pathway (GO:0007215)3.36533182
50response to peptidoglycan (GO:0032494)3.36200873
51dendritic spine morphogenesis (GO:0060997)3.34838876
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34608255
53neuromuscular process controlling balance (GO:0050885)3.31822887
54regulation of ARF protein signal transduction (GO:0032012)3.31657212
55adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.30524532
56neuron cell-cell adhesion (GO:0007158)3.30171324
57cellular extravasation (GO:0045123)3.29274190
58macrophage activation involved in immune response (GO:0002281)3.26466038
59positive regulation of membrane potential (GO:0045838)3.23396214
60regulation of postsynaptic membrane potential (GO:0060078)3.22529451
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.21713782
62behavioral response to cocaine (GO:0048148)3.15297120
63regulation of synaptic plasticity (GO:0048167)3.14585021
64auditory behavior (GO:0031223)3.14414600
65detection of other organism (GO:0098543)3.13602862
66hypotonic response (GO:0006971)3.12898557
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12043253
68dopamine receptor signaling pathway (GO:0007212)3.11802153
69proline transport (GO:0015824)3.11764388
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11139690
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09714585
72striatum development (GO:0021756)3.09228128
73response to laminar fluid shear stress (GO:0034616)3.08427796
74nuclear pore complex assembly (GO:0051292)3.08349649
75response to auditory stimulus (GO:0010996)3.04922216
76response to host (GO:0075136)3.04475188
77response to host defenses (GO:0052200)3.04475188
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.04475188
79positive regulation of synapse maturation (GO:0090129)3.03432728
80nerve growth factor signaling pathway (GO:0038180)3.02883511
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02351266
82detection of external biotic stimulus (GO:0098581)3.00936411
83neutrophil activation involved in immune response (GO:0002283)3.00023580
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.99725860
85leukocyte aggregation (GO:0070486)2.99239449
86neutrophil mediated immunity (GO:0002446)2.99171213
87long-term synaptic potentiation (GO:0060291)2.98616866
88regulation of dendritic spine development (GO:0060998)2.96869477
89sodium ion export (GO:0071436)2.96064276
90neuronal action potential propagation (GO:0019227)2.95132952
91vesicle transport along microtubule (GO:0047496)2.94723703
92antigen processing and presentation of endogenous antigen (GO:0019883)2.93866245
93regulation of female receptivity (GO:0045924)2.93799879
94negative regulation of interleukin-12 production (GO:0032695)2.93355425
95cAMP catabolic process (GO:0006198)2.91671397
96germinal center formation (GO:0002467)2.91393571
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91143870
98response to host immune response (GO:0052572)2.91143870
99iron ion import (GO:0097286)2.90667706
100positive regulation of neurotransmitter transport (GO:0051590)2.89414444
101regulation of interferon-beta biosynthetic process (GO:0045357)2.88816095
102clathrin coat assembly (GO:0048268)2.87406200
103cellular potassium ion homeostasis (GO:0030007)2.86315800
104glycine transport (GO:0015816)2.85606808
105positive regulation of neurotransmitter secretion (GO:0001956)2.84698863
106synaptic transmission, dopaminergic (GO:0001963)2.84227066
107cAMP biosynthetic process (GO:0006171)2.83099941
108response to interleukin-15 (GO:0070672)2.82862322
109regulation of B cell receptor signaling pathway (GO:0050855)2.80591356
110membrane depolarization during action potential (GO:0086010)2.80521363
111transmission of nerve impulse (GO:0019226)2.80156619
112dendrite morphogenesis (GO:0048813)2.79965002
113neurotransmitter transport (GO:0006836)2.79111473
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78706771
115membrane depolarization (GO:0051899)2.77885193
116regulation of Rap GTPase activity (GO:0032317)2.77008761
117adenosine receptor signaling pathway (GO:0001973)2.76726124
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76572485
119hepatocyte apoptotic process (GO:0097284)2.74865205
120cAMP metabolic process (GO:0046058)2.73460503
121regulation of neurotransmitter levels (GO:0001505)2.73031458
122regulation of glutamate secretion (GO:0014048)2.71917303
123response to amphetamine (GO:0001975)2.71038403
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70273146
125detection of bacterium (GO:0016045)2.69888514
126regulation of leukocyte degranulation (GO:0043300)2.69246085
127regulation of gamma-delta T cell activation (GO:0046643)2.67443767
128neuronal ion channel clustering (GO:0045161)2.66694353
129behavioral defense response (GO:0002209)2.66090776
130behavioral fear response (GO:0001662)2.66090776
131granulocyte activation (GO:0036230)2.65650733
132regulation of neurotransmitter secretion (GO:0046928)2.65270159
133stress fiber assembly (GO:0043149)2.65204800
134mechanosensory behavior (GO:0007638)2.64896285
135regulation of necroptotic process (GO:0060544)2.64459586
136neuron recognition (GO:0008038)2.64209625
137visual learning (GO:0008542)2.62425691
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62195034
139cerebellar Purkinje cell differentiation (GO:0021702)2.61914195
140membrane hyperpolarization (GO:0060081)2.61348330
141regulation of voltage-gated calcium channel activity (GO:1901385)2.60708008
142learning (GO:0007612)2.60125170
143positive regulation of synaptic transmission (GO:0050806)2.59349753
144cyclic nucleotide catabolic process (GO:0009214)2.59223133
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59036863
146response to muramyl dipeptide (GO:0032495)2.58533143
147neuromuscular process (GO:0050905)2.57829449
148synaptic vesicle endocytosis (GO:0048488)2.57391274
149negative regulation of dendrite development (GO:2000171)2.57129705
150neutrophil activation (GO:0042119)2.56824888
151embryonic process involved in female pregnancy (GO:0060136)2.56720308
152histone H3-K36 demethylation (GO:0070544)2.56641443
153L-amino acid import (GO:0043092)2.56257828
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56228323
155detection of biotic stimulus (GO:0009595)2.52380580
156nuclear pore organization (GO:0006999)2.51845178
157regulation of defense response to virus by virus (GO:0050690)2.49983338
158positive regulation of cellular amide metabolic process (GO:0034250)2.49720271
159skin morphogenesis (GO:0043589)2.48820520
160phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47305156
161Golgi transport vesicle coating (GO:0048200)2.44913438
162COPI coating of Golgi vesicle (GO:0048205)2.44913438
163regulation of nucleobase-containing compound transport (GO:0032239)2.44127443
164myeloid leukocyte mediated immunity (GO:0002444)2.43713283
165negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43003369
166modulation by symbiont of host cellular process (GO:0044068)2.42055671
167cell adhesion mediated by integrin (GO:0033627)2.40075876
168peptidyl-threonine modification (GO:0018210)2.39853832
169regulation of NFAT protein import into nucleus (GO:0051532)2.38650710
170negative regulation of lymphocyte mediated immunity (GO:0002707)2.37794901
171peptidyl-threonine phosphorylation (GO:0018107)2.36123639
172leukocyte migration involved in inflammatory response (GO:0002523)2.35620360
173pentose-phosphate shunt (GO:0006098)2.34559126
174NIK/NF-kappaB signaling (GO:0038061)2.33804463
1753-UTR-mediated mRNA stabilization (GO:0070935)2.32998353
176antigen processing and presentation via MHC class Ib (GO:0002475)2.31235635
177JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.31144430
178regulation of gamma-delta T cell differentiation (GO:0045586)2.29123045
179regulation of mast cell degranulation (GO:0043304)2.28826783
180regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27474752
181pore complex assembly (GO:0046931)2.27418376
182regulation of myeloid leukocyte mediated immunity (GO:0002886)2.26940747
183production of molecular mediator involved in inflammatory response (GO:0002532)2.26814635
184regulation of regulated secretory pathway (GO:1903305)2.26787345
185positive regulation of leukocyte degranulation (GO:0043302)2.26126469
186negative thymic T cell selection (GO:0045060)2.25825776
187B cell receptor signaling pathway (GO:0050853)2.25673930
188regulation of RNA export from nucleus (GO:0046831)2.25500654
189cellular response to type I interferon (GO:0071357)2.24253829
190type I interferon signaling pathway (GO:0060337)2.24253829
191regulation of macrophage cytokine production (GO:0010935)2.22589994
192negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22227311
193cortical actin cytoskeleton organization (GO:0030866)2.21969129
194positive regulation of receptor recycling (GO:0001921)2.21775446
195negative regulation of leukocyte mediated immunity (GO:0002704)2.21304208
196dosage compensation (GO:0007549)2.20105717
197macrophage activation (GO:0042116)2.19814279
198regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19395014
199response to type I interferon (GO:0034340)2.18914673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62595468
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.08675087
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54280422
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.39765973
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93359322
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.88335597
7GBX2_23144817_ChIP-Seq_PC3_Human2.85974025
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83951355
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75865147
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69641520
11MYC_22102868_ChIP-Seq_BL_Human2.61621349
12DROSHA_22980978_ChIP-Seq_HELA_Human2.56908634
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.51289646
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43935669
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42547529
16TCF7_22412390_ChIP-Seq_EML_Mouse2.37315808
17REST_21632747_ChIP-Seq_MESCs_Mouse2.35108124
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28989132
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.26137944
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21487510
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.20827197
22VDR_21846776_ChIP-Seq_THP-1_Human2.20692670
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19177695
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18049032
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17919462
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14389605
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13548366
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06146963
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05623820
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05623820
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03925062
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02170072
33IRF8_21731497_ChIP-ChIP_J774_Mouse2.01635948
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99423632
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95924632
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.95814492
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.93643268
38AR_21572438_ChIP-Seq_LNCaP_Human1.93616714
39SPI1_23127762_ChIP-Seq_K562_Human1.92959368
40VDR_24763502_ChIP-Seq_THP-1_Human1.91167273
41KDM2B_26808549_Chip-Seq_DND41_Human1.90987441
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90695463
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.88992535
44MAF_26560356_Chip-Seq_TH1_Human1.87890784
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87478544
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86571820
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82736855
48RUNX_20019798_ChIP-Seq_JUKART_Human1.80961010
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80433549
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78283537
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.77003439
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76282674
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75755703
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74595005
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71464255
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70564546
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.67313651
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67199291
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66136664
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.65921869
61SCL_19346495_ChIP-Seq_HPC-7_Human1.65580110
62SPI1_23547873_ChIP-Seq_NB4_Human1.64531728
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63374081
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62095690
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.59485017
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.58942927
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57934596
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.57544895
69UTX_26944678_Chip-Seq_JUKART_Human1.57360468
70TAF15_26573619_Chip-Seq_HEK293_Human1.56000331
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55653323
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.54457391
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54246532
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53489222
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51458710
76PU_27001747_Chip-Seq_BMDM_Mouse1.48008021
77MYB_26560356_Chip-Seq_TH1_Human1.47899327
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46222422
79SMAD4_21799915_ChIP-Seq_A2780_Human1.45259471
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43576787
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43576787
82MYB_26560356_Chip-Seq_TH2_Human1.42330584
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41018474
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40945280
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40416720
86CLOCK_20551151_ChIP-Seq_293T_Human1.39286362
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37267514
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37218711
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36004021
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34453269
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34071163
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.33731195
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33724341
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.33256897
95RACK7_27058665_Chip-Seq_MCF-7_Human1.32414949
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.32243288
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32112158
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.30309026
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27518883
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.27076629
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26892007
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25924921
103STAT3_23295773_ChIP-Seq_U87_Human1.24878386
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24496132
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24135952
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23500211
107KDM2B_26808549_Chip-Seq_K562_Human1.22953652
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.22786117
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22759940
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22691981
111AR_19668381_ChIP-Seq_PC3_Human1.22197290
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.20654213
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20476879
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18576831
115BP1_19119308_ChIP-ChIP_Hs578T_Human1.18414216
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17824602
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17467189
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17324317
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16376554
120VDR_24787735_ChIP-Seq_THP-1_Human1.16018443
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.15995955
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15799330
123MAF_26560356_Chip-Seq_TH2_Human1.15443197
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15206155
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15154257
126AHR_22903824_ChIP-Seq_MCF-7_Human1.15043772
127TFEB_21752829_ChIP-Seq_HELA_Human1.14916291
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14816086
129GATA1_22025678_ChIP-Seq_K562_Human1.13785273
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13471335
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12635139
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.12553864
133P300_19829295_ChIP-Seq_ESCs_Human1.12393464
134TCF4_23295773_ChIP-Seq_U87_Human1.12016075
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10857703
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10664856
137AR_25329375_ChIP-Seq_VCAP_Human1.10498073
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09888755
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09788066
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07859078
141LXR_22292898_ChIP-Seq_THP-1_Human1.07836008
142GATA2_19941826_ChIP-Seq_K562_Human1.07535566
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06110795
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05975710
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04402538
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04047452
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03692210
148P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03665889
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03520013
150NCOR1_26117541_ChIP-Seq_K562_Human1.02875198
151ATF3_27146783_Chip-Seq_COLON_Human1.02831050
152CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02282960
153UBF1/2_26484160_Chip-Seq_HMECs_Human1.00923894
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99390840
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99330918
156ESR1_20079471_ChIP-ChIP_T-47D_Human0.98098679
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97221544
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97092851
159TP53_16413492_ChIP-PET_HCT116_Human0.96797969
160FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96572685
161WT1_19549856_ChIP-ChIP_CCG9911_Human0.96509345
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.96248172
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95767052
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94661417
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.94417718
166RXR_22108803_ChIP-Seq_LS180_Human0.94412998
167TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93582027
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.93207706
169KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93200637
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93156547
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.93121886
172BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92662371
173RING1B_27294783_Chip-Seq_ESCs_Mouse0.91149249
174TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90458618
175GATA1_19941826_ChIP-Seq_K562_Human0.90205376
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89820466
177PRDM14_20953172_ChIP-Seq_ESCs_Human0.89688986
178CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88606906
179TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87560498
180ZNF274_21170338_ChIP-Seq_K562_Hela0.87499294
181THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87328536
182SMAD4_21741376_ChIP-Seq_EPCs_Human0.87098547
183SMAD3_21741376_ChIP-Seq_ESCs_Human0.85975489
184CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85174523
185STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84655304
186RUNX2_22187159_ChIP-Seq_PCA_Human0.83468174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.55240070
2MP0002822_catalepsy5.49879964
3MP0003635_abnormal_synaptic_transmissio3.93963947
4MP0003880_abnormal_central_pattern3.75299908
5MP0004270_analgesia3.58617730
6MP0003705_abnormal_hypodermis_morpholog3.44401929
7MP0002063_abnormal_learning/memory/cond3.30563809
8MP0009745_abnormal_behavioral_response3.25812875
9MP0005451_abnormal_body_composition2.95247505
10MP0002064_seizures2.94623179
11MP0008260_abnormal_autophagy2.90490443
12MP0003436_decreased_susceptibility_to2.73806674
13MP0009046_muscle_twitch2.71602601
14MP0003724_increased_susceptibility_to2.71367423
15MP0002572_abnormal_emotion/affect_behav2.60171595
16MP0001968_abnormal_touch/_nociception2.41033173
17MP0001486_abnormal_startle_reflex2.38066307
18MP0003329_amyloid_beta_deposits2.28026278
19MP0002272_abnormal_nervous_system2.26236722
20MP0002734_abnormal_mechanical_nocicepti2.19011337
21MP0002877_abnormal_melanocyte_morpholog2.18804633
22MP0003091_abnormal_cell_migration2.18318305
23MP0003566_abnormal_cell_adhesion2.16876402
24MP0010352_gastrointestinal_tract_polyps2.12825574
25MP0001501_abnormal_sleep_pattern2.01168104
26MP0002735_abnormal_chemical_nociception2.01070851
27MP0001835_abnormal_antigen_presentation1.99905954
28MP0005076_abnormal_cell_differentiation1.96631633
29MP0002909_abnormal_adrenal_gland1.95507288
30MP0002419_abnormal_innate_immunity1.89986640
31MP0004947_skin_inflammation1.89345841
32MP0008569_lethality_at_weaning1.87699253
33MP0005386_behavior/neurological_phenoty1.85871776
34MP0004924_abnormal_behavior1.85871776
35MP0000858_altered_metastatic_potential1.82485682
36MP0009780_abnormal_chondrocyte_physiolo1.81762659
37MP0003763_abnormal_thymus_physiology1.79552255
38MP0002733_abnormal_thermal_nociception1.79380234
39MP0003183_abnormal_peptide_metabolism1.78635691
40MP0005423_abnormal_somatic_nervous1.77742122
41MP0002736_abnormal_nociception_after1.76006993
42MP0001440_abnormal_grooming_behavior1.75839070
43MP0004811_abnormal_neuron_physiology1.74487218
44MP0000569_abnormal_digit_pigmentation1.73342503
45MP0000604_amyloidosis1.69457208
46MP0001970_abnormal_pain_threshold1.69060164
47MP0003828_pulmonary_edema1.67867399
48MP0004858_abnormal_nervous_system1.66212969
49MP0004264_abnormal_extraembryonic_tissu1.64292724
50MP0003633_abnormal_nervous_system1.63446935
51MP0004233_abnormal_muscle_weight1.63423308
52MP0005000_abnormal_immune_tolerance1.61100445
53MP0005025_abnormal_response_to1.56787663
54MP0003075_altered_response_to1.56483227
55MP0002067_abnormal_sensory_capabilities1.54859178
56MP0004510_myositis1.54329572
57MP0001529_abnormal_vocalization1.53219527
58MP0005464_abnormal_platelet_physiology1.53085263
59MP0002396_abnormal_hematopoietic_system1.50797689
60MP0003453_abnormal_keratinocyte_physiol1.49813284
61MP0004808_abnormal_hematopoietic_stem1.48437686
62MP0003690_abnormal_glial_cell1.47078176
63MP0005058_abnormal_lysosome_morphology1.45393171
64MP0009278_abnormal_bone_marrow1.42583629
65MP0001533_abnormal_skeleton_physiology1.42442417
66MP0001800_abnormal_humoral_immune1.41487491
67MP0002405_respiratory_system_inflammati1.41465570
68MP0000015_abnormal_ear_pigmentation1.40239014
69MP0002420_abnormal_adaptive_immunity1.40159311
70MP0001984_abnormal_olfaction1.39711661
71MP0003631_nervous_system_phenotype1.39557217
72MP0001819_abnormal_immune_cell1.39475792
73MP0002452_abnormal_antigen_presenting1.39449098
74MP0000685_abnormal_immune_system1.38749234
75MP0008874_decreased_physiological_sensi1.38702191
76MP0000778_abnormal_nervous_system1.37655530
77MP0001849_ear_inflammation1.37636952
78MP0006082_CNS_inflammation1.37181410
79MP0003221_abnormal_cardiomyocyte_apopto1.36538036
80MP0005646_abnormal_pituitary_gland1.35669241
81MP0009785_altered_susceptibility_to1.34037199
82MP0002557_abnormal_social/conspecific_i1.33880585
83MP0002723_abnormal_immune_serum1.33675545
84MP0002166_altered_tumor_susceptibility1.32656940
85MP0004185_abnormal_adipocyte_glucose1.32365046
86MP0005310_abnormal_salivary_gland1.30773281
87MP0003879_abnormal_hair_cell1.28602871
88MP0004130_abnormal_muscle_cell1.28432601
89MP0002398_abnormal_bone_marrow1.28221042
90MP0004885_abnormal_endolymph1.27971868
91MP0002009_preneoplasia1.27591881
92MP0002066_abnormal_motor_capabilities/c1.27245434
93MP0008057_abnormal_DNA_replication1.26669182
94MP0000920_abnormal_myelination1.25944968
95MP0000955_abnormal_spinal_cord1.25739291
96MP0003448_altered_tumor_morphology1.24804416
97MP0002006_tumorigenesis1.23906620
98MP0001790_abnormal_immune_system1.23480024
99MP0005387_immune_system_phenotype1.23480024
100MP0010155_abnormal_intestine_physiology1.20454085
101MP0000703_abnormal_thymus_morphology1.18740761
102MP0005535_abnormal_body_temperature1.18231868
103MP0003656_abnormal_erythrocyte_physiolo1.18221552
104MP0003303_peritoneal_inflammation1.18061446
105MP0002998_abnormal_bone_remodeling1.16197800
106MP0002184_abnormal_innervation1.16129186
107MP0005621_abnormal_cell_physiology1.14007477
108MP0002837_dystrophic_cardiac_calcinosis1.12957390
109MP0000716_abnormal_immune_system1.12442365
110MP0004381_abnormal_hair_follicle1.12417521
111MP0002722_abnormal_immune_system1.11715157
112MP0001915_intracranial_hemorrhage1.11124968
113MP0000465_gastrointestinal_hemorrhage1.10585250
114MP0002882_abnormal_neuron_morphology1.09512439
115MP0010234_abnormal_vibrissa_follicle1.08815572
116MP0005167_abnormal_blood-brain_barrier1.07856593
117MP0004883_abnormal_blood_vessel1.05681847
118MP0002148_abnormal_hypersensitivity_rea1.05496245
119MP0005360_urolithiasis1.03806831
120MP0003632_abnormal_nervous_system1.03503851
121MP0010307_abnormal_tumor_latency1.00519251
122MP0001851_eye_inflammation1.00509147
123MP0005085_abnormal_gallbladder_physiolo1.00505477
124MP0001177_atelectasis1.00482781
125MP0005248_abnormal_Harderian_gland1.00372075
126MP0003787_abnormal_imprinting0.99691244
127MP0006054_spinal_hemorrhage0.98970924
128MP0001845_abnormal_inflammatory_respons0.98881447
129MP0002229_neurodegeneration0.96624054
130MP0002429_abnormal_blood_cell0.96535706
131MP0004085_abnormal_heartbeat0.96491757
132MP0000689_abnormal_spleen_morphology0.95956908
133MP0003172_abnormal_lysosome_physiology0.94881365
134MP0002332_abnormal_exercise_endurance0.94767505
135MP0005164_abnormal_response_to0.94620561
136MP0001545_abnormal_hematopoietic_system0.94268342
137MP0005397_hematopoietic_system_phenotyp0.94268342
138MP0001502_abnormal_circadian_rhythm0.94139747
139MP0003634_abnormal_glial_cell0.93117508
140MP0002090_abnormal_vision0.93072086
141MP0008961_abnormal_basal_metabolism0.92465418
142MP0000767_abnormal_smooth_muscle0.92436411
143MP0008872_abnormal_physiological_respon0.92280980
144MP0000013_abnormal_adipose_tissue0.92198484
145MP0003866_abnormal_defecation0.91848671
146MP0002152_abnormal_brain_morphology0.91210747
147MP0002069_abnormal_eating/drinking_beha0.87143260
148MP0010329_abnormal_lipoprotein_level0.86811571
149MP0000751_myopathy0.86071485
150MP0002139_abnormal_hepatobiliary_system0.84575186
151MP0002796_impaired_skin_barrier0.84320820
152MP0001905_abnormal_dopamine_level0.83966451
153MP0001348_abnormal_lacrimal_gland0.83098778
154MP0005671_abnormal_response_to0.81812427
155MP0003300_gastrointestinal_ulcer0.80197238
156MP0010678_abnormal_skin_adnexa0.79888219
157MP0002086_abnormal_extraembryonic_tissu0.76928432
158MP0000490_abnormal_crypts_of0.75864706
159MP0001216_abnormal_epidermal_layer0.75160338
160MP0005584_abnormal_enzyme/coenzyme_acti0.73902120
161MP0009764_decreased_sensitivity_to0.73273939
162MP0005166_decreased_susceptibility_to0.73009082
163MP0001958_emphysema0.72966987
164MP0005023_abnormal_wound_healing0.72525938
165MP0005384_cellular_phenotype0.72219216
166MP0009840_abnormal_foam_cell0.72215254
167MP0005645_abnormal_hypothalamus_physiol0.72098658
168MP0003646_muscle_fatigue0.71761065
169MP0004142_abnormal_muscle_tone0.71754826
170MP0006276_abnormal_autonomic_nervous0.71639438
171MP0005410_abnormal_fertilization0.70715612
172MP0004215_abnormal_myocardial_fiber0.68843006
173MP0004036_abnormal_muscle_relaxation0.68726042
174MP0005409_darkened_coat_color0.67919148
175MP0005365_abnormal_bile_salt0.67698908
176MP0003252_abnormal_bile_duct0.64756279
177MP0003045_fibrosis0.62958927
178MP0002118_abnormal_lipid_homeostasis0.62794358
179MP0005448_abnormal_energy_balance0.60312858
180MP0004484_altered_response_of0.60124589
181MP0005623_abnormal_meninges_morphology0.57862688
182MP0010386_abnormal_urinary_bladder0.57481189
183MP0002078_abnormal_glucose_homeostasis0.56960448
184MP0005551_abnormal_eye_electrophysiolog0.56678287
185MP0003191_abnormal_cellular_cholesterol0.54188882
186MP0005187_abnormal_penis_morphology0.53464957

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.28531337
2Focal motor seizures (HP:0011153)5.97361156
3Focal seizures (HP:0007359)4.87703278
4Eczematoid dermatitis (HP:0000976)4.02577004
5Visual hallucinations (HP:0002367)3.99332791
6Action tremor (HP:0002345)3.70568246
7Poor eye contact (HP:0000817)3.66324362
8Epileptic encephalopathy (HP:0200134)3.64747962
9Impaired social interactions (HP:0000735)3.61023697
10Abnormal social behavior (HP:0012433)3.61023697
11Supranuclear gaze palsy (HP:0000605)3.51849924
12Impaired vibration sensation in the lower limbs (HP:0002166)3.47187900
13Atonic seizures (HP:0010819)3.33553359
14Urinary bladder sphincter dysfunction (HP:0002839)3.31442295
15Recurrent abscess formation (HP:0002722)3.31118772
16Cerebral inclusion bodies (HP:0100314)3.28781888
17Febrile seizures (HP:0002373)3.27840760
18Neurofibrillary tangles (HP:0002185)3.26364852
19Generalized tonic-clonic seizures (HP:0002069)3.26183986
20Recurrent bacterial skin infections (HP:0005406)3.20313165
21Papilledema (HP:0001085)3.20306582
22Dysmetric saccades (HP:0000641)3.19552675
23Depression (HP:0000716)3.17856725
24Hyperventilation (HP:0002883)3.14915185
25Absence seizures (HP:0002121)3.14867726
26Ankle clonus (HP:0011448)3.14434406
27Subacute progressive viral hepatitis (HP:0006572)3.13082247
28Urinary urgency (HP:0000012)3.07543712
29Dysdiadochokinesis (HP:0002075)3.07025064
30Progressive cerebellar ataxia (HP:0002073)3.03923852
31Postural instability (HP:0002172)3.02642905
32Insidious onset (HP:0003587)3.00762705
33Termporal pattern (HP:0011008)3.00762705
34Dysmetria (HP:0001310)2.97243389
35Abnormality of the lower motor neuron (HP:0002366)2.94702948
36Dialeptic seizures (HP:0011146)2.88888530
37Anxiety (HP:0000739)2.87923116
38Gaze-evoked nystagmus (HP:0000640)2.87138522
39Abnormality of macrophages (HP:0004311)2.86736993
40Truncal ataxia (HP:0002078)2.84239891
41Intention tremor (HP:0002080)2.84175993
42Resting tremor (HP:0002322)2.81591973
43Broad-based gait (HP:0002136)2.81146724
44Spastic gait (HP:0002064)2.78027468
45Torticollis (HP:0000473)2.76939900
46Abnormality of the corticospinal tract (HP:0002492)2.74510664
47Gingivitis (HP:0000230)2.71188512
48Arterial tortuosity (HP:0005116)2.70702881
49Orchitis (HP:0100796)2.69453371
50Impaired smooth pursuit (HP:0007772)2.62721803
51Scanning speech (HP:0002168)2.58825264
52Recurrent gram-negative bacterial infections (HP:0005420)2.58161085
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56478498
54Peritonitis (HP:0002586)2.55087070
55Impaired vibratory sensation (HP:0002495)2.52360577
56Myositis (HP:0100614)2.45940713
57Lower limb amyotrophy (HP:0007210)2.43672842
58Progressive inability to walk (HP:0002505)2.43396405
59Excessive salivation (HP:0003781)2.43210901
60Drooling (HP:0002307)2.43210901
61Status epilepticus (HP:0002133)2.42965720
62Syringomyelia (HP:0003396)2.40839606
63Spinal cord lesions (HP:0100561)2.40839606
64Focal dystonia (HP:0004373)2.40067983
65Vascular tortuosity (HP:0004948)2.36481727
66Hemiplegia (HP:0002301)2.36060308
67Lower limb muscle weakness (HP:0007340)2.35833677
68Stereotypic behavior (HP:0000733)2.35429701
69Epileptiform EEG discharges (HP:0011182)2.35333005
70Cellulitis (HP:0100658)2.34983987
71Insomnia (HP:0100785)2.32287812
72Abnormality of saccadic eye movements (HP:0000570)2.32091828
73Amblyopia (HP:0000646)2.31104344
74Hyperacusis (HP:0010780)2.30685867
75EEG with generalized epileptiform discharges (HP:0011198)2.28849330
76Abnormal eating behavior (HP:0100738)2.27942625
77Bradykinesia (HP:0002067)2.27233845
78Flat acetabular roof (HP:0003180)2.27101316
79Hypsarrhythmia (HP:0002521)2.26268177
80Abnormality of ocular smooth pursuit (HP:0000617)2.25654238
81Craniofacial dystonia (HP:0012179)2.23684991
82Megalencephaly (HP:0001355)2.23483724
83Bundle branch block (HP:0011710)2.20707875
84Neuronal loss in central nervous system (HP:0002529)2.20132610
85Spontaneous hematomas (HP:0007420)2.16794202
86Spastic tetraparesis (HP:0001285)2.16724645
87Hemiparesis (HP:0001269)2.16098596
88Mutism (HP:0002300)2.16001410
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.15585132
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15585132
91Optic neuritis (HP:0100653)2.15199726
92Retrobulbar optic neuritis (HP:0100654)2.15199726
93Genetic anticipation (HP:0003743)2.15153641
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.14519915
95Osteolytic defects of the hand bones (HP:0009699)2.14519915
96Diplopia (HP:0000651)2.14240339
97Abnormality of binocular vision (HP:0011514)2.14240339
98Long palpebral fissure (HP:0000637)2.13892512
99Asymmetry of the thorax (HP:0001555)2.13791962
100Annular pancreas (HP:0001734)2.09290736
101T lymphocytopenia (HP:0005403)2.08738878
102Clonus (HP:0002169)2.07050780
103Blue irides (HP:0000635)2.06723783
104Viral hepatitis (HP:0006562)2.05846565
105Abnormality of the periventricular white matter (HP:0002518)2.04760864
106Interstitial pulmonary disease (HP:0006530)2.04379695
107Broad face (HP:0000283)2.00897128
108Slow saccadic eye movements (HP:0000514)1.99044525
109Amyotrophic lateral sclerosis (HP:0007354)1.98361852
110Vertebral compression fractures (HP:0002953)1.98336963
111Micronodular cirrhosis (HP:0001413)1.96637342
112Myocardial infarction (HP:0001658)1.96542291
113Heterotopia (HP:0002282)1.96069762
114Upper motor neuron abnormality (HP:0002127)1.95566504
115Recurrent skin infections (HP:0001581)1.94560734
116Gastrointestinal infarctions (HP:0005244)1.94171203
117Pointed chin (HP:0000307)1.93356828
118Distal lower limb amyotrophy (HP:0008944)1.91665589
119Recurrent fungal infections (HP:0002841)1.91123361
120Spondylolisthesis (HP:0003302)1.90230925
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.89524406
122Pheochromocytoma (HP:0002666)1.89360608
123Global brain atrophy (HP:0002283)1.88015328
124Generalized myoclonic seizures (HP:0002123)1.87645976
125Difficulty running (HP:0009046)1.85406252
126Abnormality of the peritoneum (HP:0002585)1.85354639
127Mediastinal lymphadenopathy (HP:0100721)1.85236695
128Absent frontal sinuses (HP:0002688)1.84402629
129Gait ataxia (HP:0002066)1.83976201
130Ankyloglossia (HP:0010296)1.82387155
131Papillary thyroid carcinoma (HP:0002895)1.82140031
132Inappropriate behavior (HP:0000719)1.81745530
133Abnormality of T cell number (HP:0011839)1.81586647
134Dilatation of the ascending aorta (HP:0005111)1.81244333
135Abnormal gallbladder physiology (HP:0012438)1.81173034
136Cholecystitis (HP:0001082)1.81173034
137Deep philtrum (HP:0002002)1.80241076
138Osteomyelitis (HP:0002754)1.80050485
139Psychosis (HP:0000709)1.79873239
140Rigidity (HP:0002063)1.79358556
141Abnormality of oral frenula (HP:0000190)1.79269940
142Recurrent viral infections (HP:0004429)1.78600813
143Loss of speech (HP:0002371)1.77760529
144Macroorchidism (HP:0000053)1.77610536
145Thick nail (HP:0001805)1.77456378
146Urticaria (HP:0001025)1.77099231
147Decreased motor nerve conduction velocity (HP:0003431)1.75842701
148Thin bony cortex (HP:0002753)1.75738411
149Deep venous thrombosis (HP:0002625)1.75625946
150Sensorimotor neuropathy (HP:0007141)1.74813764
151Abnormality of glycolipid metabolism (HP:0010969)1.73731933
152Abnormality of liposaccharide metabolism (HP:0010968)1.73731933
153Abnormality of glycosphingolipid metabolism (HP:0004343)1.73731933
154Absent speech (HP:0001344)1.73149968
155Stomatitis (HP:0010280)1.72573777
156Tetraplegia (HP:0002445)1.72382590
157Cerebral aneurysm (HP:0004944)1.72038914
158Onion bulb formation (HP:0003383)1.71910386
159Short nail (HP:0001799)1.71120436
160Rapidly progressive (HP:0003678)1.70724035
161Vertebral arch anomaly (HP:0008438)1.69718730
162Periodontitis (HP:0000704)1.68772703
163Apathy (HP:0000741)1.68760123
164Recurrent cutaneous fungal infections (HP:0011370)1.67735180
165Chronic mucocutaneous candidiasis (HP:0002728)1.67735180
166Abnormal delayed hypersensitivity skin test (HP:0002963)1.67712931
167Abnormality of vision evoked potentials (HP:0000649)1.67000627
168Aneurysm (HP:0002617)1.66813240
169Centrally nucleated skeletal muscle fibers (HP:0003687)1.66622715
170Cholelithiasis (HP:0001081)1.66559103
171Segmental peripheral demyelination/remyelination (HP:0003481)1.66424225
172Chest pain (HP:0100749)1.66252049
173Disproportionate tall stature (HP:0001519)1.63366841
174Coarse hair (HP:0002208)1.63299969
175Urinary glycosaminoglycan excretion (HP:0003541)1.61802058
176Mucopolysacchariduria (HP:0008155)1.61802058
177Orthostatic hypotension (HP:0001278)1.61662101
178Increased IgE level (HP:0003212)1.61388424
179Uterine leiomyosarcoma (HP:0002891)1.60942089
180Leiomyosarcoma (HP:0100243)1.60942089
181Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60567114
182Elevated erythrocyte sedimentation rate (HP:0003565)1.60264529
183Gingival bleeding (HP:0000225)1.59568200
184Fatigue (HP:0012378)1.59311729
185Transitional cell carcinoma of the bladder (HP:0006740)1.59046695
186Episodic fever (HP:0001954)1.58496270
187Bladder carcinoma (HP:0002862)1.58303798
188Bladder neoplasm (HP:0009725)1.58303798
189Dysostosis multiplex (HP:0000943)1.57505814
190Abnormality of the fingertips (HP:0001211)1.55951732
191Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55949363
192Arterial thrombosis (HP:0004420)1.54825009
193Bone pain (HP:0002653)1.53614296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.08598399
2NTRK33.49239143
3MAP3K93.36614171
4DAPK22.89985144
5CDK122.87350556
6MARK12.65201372
7EPHB12.63158495
8MAP3K42.62841555
9IRAK32.61206242
10RIPK42.55510329
11MAP2K32.50083218
12KSR22.44262880
13ERN12.37665719
14SMG12.29807818
15PRKD32.24054308
16PAK62.07404906
17CAMKK12.01628002
18MINK11.98676711
19PRPF4B1.97794048
20MAP3K131.93296646
21MAP3K141.87048408
22NTRK11.85931920
23IRAK41.84740238
24NTRK21.83785737
25TYK21.67289601
26CSK1.62928359
27MAP2K71.60002273
28KSR11.59150487
29FGFR41.58559223
30MAP4K11.58103120
31MAP3K31.55349335
32MAP2K41.50493099
33CDK51.49387272
34YES11.48606689
35BLK1.47640784
36SIK21.44043254
37SIK31.43268328
38ZAP701.41331618
39DAPK11.40311625
40SGK31.38749193
41TAOK31.37904882
42SIK11.35385817
43FES1.35266282
44PRKCH1.33394885
45JAK31.30207674
46SGK2231.29620734
47SGK4941.29620734
48MAP3K101.27799787
49SGK21.26341522
50PTK2B1.22831541
51PDGFRA1.21462070
52TTN1.17221457
53TRIB31.15357038
54TYRO31.14898321
55MAP3K21.10362326
56RET1.09450274
57PDK11.07472360
58ARAF1.06727998
59BRD41.05629199
60STK381.00888430
61IRAK21.00426644
62PDPK10.98850855
63TAOK20.98202740
64FGFR20.98175619
65STK110.97335775
66TGFBR20.94735616
67PTK60.94014623
68STK100.93215282
69RAF10.93077779
70RIPK10.92443074
71CDK60.90442744
72IRAK10.90414305
73CAMK1D0.87585323
74SGK10.87051684
75PLK20.86822344
76HCK0.86119281
77CDC42BPA0.84433848
78MELK0.83748348
79PHKG10.83270380
80PHKG20.83270380
81PAK40.83039153
82PRKCG0.82712056
83PDGFRB0.82503778
84TAOK10.82016105
85PRKD20.82007957
86CAMKK20.81946237
87LMTK20.80675888
88MAP3K60.79637131
89LRRK20.78031639
90JAK10.77751147
91WNK10.77343578
92MAPK130.77152662
93NEK60.75144921
94MAP3K70.74727946
95PTK20.74208269
96CASK0.72823485
97MTOR0.72580164
98IKBKE0.72503174
99ALK0.72314801
100PAK30.71838239
101MST1R0.71666006
102MAP3K80.71644382
103CAMK2A0.70916071
104CAMK1G0.70188683
105MARK20.69291168
106BTK0.67920618
107TESK20.67314154
108CDK150.66300903
109PKN10.65393695
110PKN20.65363591
111CDK180.65208097
112UHMK10.65147992
113EPHA20.64246395
114PRKCZ0.63636480
115FYN0.63162526
116MATK0.62953227
117EPHA30.62804792
118PDK40.61815427
119PDK30.61815427
120CAMK2B0.61525614
121HIPK20.61056086
122NEK90.59823559
123PINK10.59377836
124TBK10.59266126
125PRKCQ0.58914011
126CDK140.58594200
127BMPR20.57921470
128GRK50.57306729
129CSNK1G20.55346921
130RPS6KA30.54874373
131ICK0.53096050
132MAP2K10.52450810
133CDK11A0.52248188
134LATS20.51898279
135CDK40.51636624
136EIF2AK10.51077599
137MAP3K120.50281021
138DMPK0.50222841
139GRK60.49289106
140DYRK1B0.49205198
141CSF1R0.48967999
142CAMK10.47995889
143MAP3K10.47487889
144RPS6KA20.46716550
145MAP3K110.45119510
146FGR0.44994139
147EEF2K0.44891432
148BMX0.44888664
149MOS0.44879347
150LCK0.43328361
151MAP3K50.43063189
152JAK20.42562269
153PDK20.41776115
154SYK0.41640231
155FGFR30.41062868
156MAPK100.39944679
157TESK10.39363787
158MAPK120.39339926
159PRKCB0.39319971
160TNK20.39048478
161DAPK30.38583300
162CLK10.36997569
163FRK0.36715102
164CAMK40.36232101
165SCYL20.35721617
166PRKAA10.35103858

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.80591271
2Nicotine addiction_Homo sapiens_hsa050332.43472958
3Nitrogen metabolism_Homo sapiens_hsa009102.43462296
4Synaptic vesicle cycle_Homo sapiens_hsa047212.33478343
5Morphine addiction_Homo sapiens_hsa050322.28953614
6Long-term potentiation_Homo sapiens_hsa047202.27867986
7GABAergic synapse_Homo sapiens_hsa047272.24682829
8Circadian entrainment_Homo sapiens_hsa047132.24538631
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23682074
10Chronic myeloid leukemia_Homo sapiens_hsa052202.18055165
11Glutamatergic synapse_Homo sapiens_hsa047242.15633966
12Amphetamine addiction_Homo sapiens_hsa050312.03864898
13Pancreatic cancer_Homo sapiens_hsa052122.02491282
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02198409
15Osteoclast differentiation_Homo sapiens_hsa043801.92832749
16Dopaminergic synapse_Homo sapiens_hsa047281.90544444
17Acute myeloid leukemia_Homo sapiens_hsa052211.90145799
18Salivary secretion_Homo sapiens_hsa049701.79980698
19Cholinergic synapse_Homo sapiens_hsa047251.76246763
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71383824
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65669455
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59815430
23Renin secretion_Homo sapiens_hsa049241.59340545
24Cocaine addiction_Homo sapiens_hsa050301.58546515
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56816400
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56720161
27Gastric acid secretion_Homo sapiens_hsa049711.55712316
28Insulin secretion_Homo sapiens_hsa049111.53095168
29Thyroid cancer_Homo sapiens_hsa052161.52858187
30Measles_Homo sapiens_hsa051621.51927873
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49106139
32Hepatitis B_Homo sapiens_hsa051611.45800648
33Oxytocin signaling pathway_Homo sapiens_hsa049211.44171011
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42975200
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40920644
36Type II diabetes mellitus_Homo sapiens_hsa049301.40450712
37Leishmaniasis_Homo sapiens_hsa051401.40412716
38T cell receptor signaling pathway_Homo sapiens_hsa046601.36971631
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36122017
40Hepatitis C_Homo sapiens_hsa051601.32669999
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30005479
42Calcium signaling pathway_Homo sapiens_hsa040201.28468440
43Influenza A_Homo sapiens_hsa051641.27019900
44TNF signaling pathway_Homo sapiens_hsa046681.27001886
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.26684990
46Colorectal cancer_Homo sapiens_hsa052101.25564587
47Long-term depression_Homo sapiens_hsa047301.24680315
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24230442
49Tuberculosis_Homo sapiens_hsa051521.22992026
50Glioma_Homo sapiens_hsa052141.22248928
51Apoptosis_Homo sapiens_hsa042101.22020246
52Toxoplasmosis_Homo sapiens_hsa051451.21698503
53Other glycan degradation_Homo sapiens_hsa005111.21050094
54Prostate cancer_Homo sapiens_hsa052151.19428419
55Taste transduction_Homo sapiens_hsa047421.18980073
56Gap junction_Homo sapiens_hsa045401.18676304
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16567904
58Malaria_Homo sapiens_hsa051441.16396454
59Shigellosis_Homo sapiens_hsa051311.15596763
60GnRH signaling pathway_Homo sapiens_hsa049121.15508166
61Serotonergic synapse_Homo sapiens_hsa047261.15124857
62cAMP signaling pathway_Homo sapiens_hsa040241.15005900
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.14739421
64Bladder cancer_Homo sapiens_hsa052191.13403184
65Legionellosis_Homo sapiens_hsa051341.10321683
66Small cell lung cancer_Homo sapiens_hsa052221.10117514
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.09748675
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08411531
69Adherens junction_Homo sapiens_hsa045201.07838897
70Notch signaling pathway_Homo sapiens_hsa043301.06103833
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05504827
72Proteoglycans in cancer_Homo sapiens_hsa052051.04072571
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04053285
74Estrogen signaling pathway_Homo sapiens_hsa049151.04034606
75Salmonella infection_Homo sapiens_hsa051321.03168803
76NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03163578
77FoxO signaling pathway_Homo sapiens_hsa040681.02729917
78Dorso-ventral axis formation_Homo sapiens_hsa043201.00895931
79Arginine biosynthesis_Homo sapiens_hsa002201.00882362
80Amoebiasis_Homo sapiens_hsa051461.00573694
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98102272
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.98046802
83Bile secretion_Homo sapiens_hsa049760.95615818
84ErbB signaling pathway_Homo sapiens_hsa040120.92868482
85MicroRNAs in cancer_Homo sapiens_hsa052060.92508276
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90119187
87Viral carcinogenesis_Homo sapiens_hsa052030.89636965
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89177046
89Focal adhesion_Homo sapiens_hsa045100.88865398
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87215765
91Butanoate metabolism_Homo sapiens_hsa006500.87084245
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.86490294
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.85428930
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84707751
95Platelet activation_Homo sapiens_hsa046110.84012204
96Non-small cell lung cancer_Homo sapiens_hsa052230.83816256
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.83644723
98HIF-1 signaling pathway_Homo sapiens_hsa040660.77853680
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76199223
100Lysosome_Homo sapiens_hsa041420.76190082
101Phagosome_Homo sapiens_hsa041450.76030106
102Axon guidance_Homo sapiens_hsa043600.75333110
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74859141
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.73414051
105Herpes simplex infection_Homo sapiens_hsa051680.73210266
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72395307
107VEGF signaling pathway_Homo sapiens_hsa043700.70475199
108Chemokine signaling pathway_Homo sapiens_hsa040620.68418249
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.67779705
110Glucagon signaling pathway_Homo sapiens_hsa049220.67611267
111mTOR signaling pathway_Homo sapiens_hsa041500.67244475
112Choline metabolism in cancer_Homo sapiens_hsa052310.66389529
113Dilated cardiomyopathy_Homo sapiens_hsa054140.65426118
114Fatty acid biosynthesis_Homo sapiens_hsa000610.64376846
115Melanogenesis_Homo sapiens_hsa049160.62729962
116Collecting duct acid secretion_Homo sapiens_hsa049660.62687785
117Pentose phosphate pathway_Homo sapiens_hsa000300.62656980
118HTLV-I infection_Homo sapiens_hsa051660.61062780
119MAPK signaling pathway_Homo sapiens_hsa040100.60563346
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59390259
121Hematopoietic cell lineage_Homo sapiens_hsa046400.58887671
122Thyroid hormone synthesis_Homo sapiens_hsa049180.58822654
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58545920
124Endometrial cancer_Homo sapiens_hsa052130.58335417
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57739221
126Insulin signaling pathway_Homo sapiens_hsa049100.57657407
127B cell receptor signaling pathway_Homo sapiens_hsa046620.57384609
128Inositol phosphate metabolism_Homo sapiens_hsa005620.56669348
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56588646
130Pancreatic secretion_Homo sapiens_hsa049720.56560330
131Pertussis_Homo sapiens_hsa051330.56401340
132Pathways in cancer_Homo sapiens_hsa052000.55701436
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.54410376
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54121252
135AMPK signaling pathway_Homo sapiens_hsa041520.54105488
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.53592203
137Endocytosis_Homo sapiens_hsa041440.53143033
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52658533
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52067063
140Melanoma_Homo sapiens_hsa052180.51446224
141Type I diabetes mellitus_Homo sapiens_hsa049400.51294358
142Rap1 signaling pathway_Homo sapiens_hsa040150.50641249
143Oocyte meiosis_Homo sapiens_hsa041140.50475207
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50287663
145Renal cell carcinoma_Homo sapiens_hsa052110.50220888
146Insulin resistance_Homo sapiens_hsa049310.46538545
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46097850
148Alcoholism_Homo sapiens_hsa050340.45884085
149Ras signaling pathway_Homo sapiens_hsa040140.44946390
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44774927
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44704459
152Prion diseases_Homo sapiens_hsa050200.43819275
153African trypanosomiasis_Homo sapiens_hsa051430.42319883
154PPAR signaling pathway_Homo sapiens_hsa033200.42043707
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41492030
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41032240
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39745611
158ABC transporters_Homo sapiens_hsa020100.39395803
159Fatty acid metabolism_Homo sapiens_hsa012120.37950229
160Prolactin signaling pathway_Homo sapiens_hsa049170.36739407
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36290464

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