ARF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.49863858
2protein retention in ER lumen (GO:0006621)6.03832940
3protein maturation by protein folding (GO:0022417)5.74830245
4* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.55237197
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.18129656
6positive regulation of nuclease activity (GO:0032075)5.12763390
7proline biosynthetic process (GO:0006561)4.77069793
8* vesicle coating (GO:0006901)4.67546344
9regulation of nuclease activity (GO:0032069)4.65715821
10COPII vesicle coating (GO:0048208)4.61920730
11regulation of early endosome to late endosome transport (GO:2000641)4.49290742
12endoplasmic reticulum unfolded protein response (GO:0030968)4.31925758
13cellular response to unfolded protein (GO:0034620)4.12243856
14cellular response to topologically incorrect protein (GO:0035967)4.08707619
15protein localization to endosome (GO:0036010)3.96916796
16regulation of translational termination (GO:0006449)3.94949412
17ER-nucleus signaling pathway (GO:0006984)3.93948762
18galactose catabolic process (GO:0019388)3.92796292
19nuclear envelope reassembly (GO:0031468)3.88709364
20mitotic nuclear envelope reassembly (GO:0007084)3.88709364
21folic acid-containing compound biosynthetic process (GO:0009396)3.88682992
22NADH metabolic process (GO:0006734)3.77488816
23tricarboxylic acid cycle (GO:0006099)3.76482933
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.67275153
25Arp2/3 complex-mediated actin nucleation (GO:0034314)3.50768556
26glucose 6-phosphate metabolic process (GO:0051156)3.44681236
27barbed-end actin filament capping (GO:0051016)3.37411665
28chaperone mediated protein folding requiring cofactor (GO:0051085)3.35792456
29oxaloacetate metabolic process (GO:0006107)3.35130022
30response to unfolded protein (GO:0006986)3.33286734
31response to endoplasmic reticulum stress (GO:0034976)3.29543497
32response to topologically incorrect protein (GO:0035966)3.28122396
33GDP-mannose metabolic process (GO:0019673)3.27006545
34nucleobase-containing small molecule interconversion (GO:0015949)3.24482879
35pentose-phosphate shunt (GO:0006098)3.20353983
36positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.20129554
37de novo protein folding (GO:0006458)3.19792261
38formation of translation preinitiation complex (GO:0001731)3.19001217
39glycolytic process (GO:0006096)3.18593768
40proline metabolic process (GO:0006560)3.18425285
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.17119602
42signal peptide processing (GO:0006465)3.16661467
43peptidyl-asparagine modification (GO:0018196)3.16288900
44tricarboxylic acid metabolic process (GO:0072350)3.15633723
45negative regulation of microtubule polymerization (GO:0031115)3.15535817
46protein N-linked glycosylation via asparagine (GO:0018279)3.15467618
47sequestering of metal ion (GO:0051238)3.14455526
48negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.12804368
49positive regulation of lamellipodium assembly (GO:0010592)3.09904992
50glucose catabolic process (GO:0006007)3.09112773
51virion assembly (GO:0019068)3.08262841
52regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07964912
53peptidyl-proline hydroxylation (GO:0019511)3.07440415
54negative regulation of cell size (GO:0045792)3.07386230
554-hydroxyproline metabolic process (GO:0019471)3.06913118
56amyloid precursor protein catabolic process (GO:0042987)3.03025911
57de novo posttranslational protein folding (GO:0051084)2.99663820
58monosaccharide biosynthetic process (GO:0046364)2.95102235
59protein deneddylation (GO:0000338)2.94342861
60regulation of protein heterodimerization activity (GO:0043497)2.93440728
61protein hydroxylation (GO:0018126)2.93096469
62ER to Golgi vesicle-mediated transport (GO:0006888)2.92858776
63membrane budding (GO:0006900)2.92710216
64localization within membrane (GO:0051668)2.89798038
65regulation of translational fidelity (GO:0006450)2.88168089
66growth hormone secretion (GO:0030252)2.85168354
67L-serine transport (GO:0015825)2.83929314
68protein N-linked glycosylation (GO:0006487)2.82839160
69protein insertion into membrane (GO:0051205)2.82695564
70positive regulation of lamellipodium organization (GO:1902745)2.80876393
71hexose biosynthetic process (GO:0019319)2.80651664
72negative regulation of protein localization to plasma membrane (GO:1903077)2.80360831
73glucocorticoid receptor signaling pathway (GO:0042921)2.78039770
74serine transport (GO:0032329)2.77625279
75chaperone-mediated protein folding (GO:0061077)2.76729582
76NADPH regeneration (GO:0006740)2.74344347
77peptidyl-arginine omega-N-methylation (GO:0035247)2.74300420
78negative regulation of erythrocyte differentiation (GO:0045647)2.73999375
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.73717098
80exocrine pancreas development (GO:0031017)2.72853352
81actin filament depolymerization (GO:0030042)2.72657235
82cullin deneddylation (GO:0010388)2.72531145
83maternal placenta development (GO:0001893)2.72518198
84deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72241651
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.71192605
86endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.70663136
87positive regulation of pseudopodium assembly (GO:0031274)2.69517719
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68797027
89positive regulation of glycoprotein metabolic process (GO:1903020)2.68506854
90ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.66583991
91actin nucleation (GO:0045010)2.64747627
92nucleoside diphosphate biosynthetic process (GO:0009133)2.62663482
93amyloid precursor protein metabolic process (GO:0042982)2.62553814
94mitochondrial calcium ion transport (GO:0006851)2.62458570
95cerebellar Purkinje cell layer development (GO:0021680)2.61690829
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60490497
97regulation of proton transport (GO:0010155)2.58643208
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.58259468
99endothelial tube morphogenesis (GO:0061154)2.57755336
100morphogenesis of an endothelium (GO:0003159)2.57755336
101regulation of type B pancreatic cell apoptotic process (GO:2000674)2.57698395
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54784152
103positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.53102695
104epithelial cell-cell adhesion (GO:0090136)2.51571969
105peptide catabolic process (GO:0043171)2.51557417
1063-UTR-mediated mRNA stabilization (GO:0070935)2.51464093
107peptide hormone processing (GO:0016486)2.51261015
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.50990553
109ATP hydrolysis coupled proton transport (GO:0015991)2.50990553
110pinocytosis (GO:0006907)2.50318945
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50039687
112pentose metabolic process (GO:0019321)2.49765273
113positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.49666890
114stress fiber assembly (GO:0043149)2.49467954
115glycosphingolipid catabolic process (GO:0046479)2.49135673
116platelet aggregation (GO:0070527)2.48238881
117negative regulation of glycoprotein biosynthetic process (GO:0010561)2.46763998
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.46753458
119misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.46606377
120nucleobase biosynthetic process (GO:0046112)2.46069334
121* antigen processing and presentation of exogenous antigen (GO:0019884)2.45101221
122Golgi organization (GO:0007030)2.45028746
123* antigen processing and presentation of exogenous peptide antigen (GO:0002478)2.43967914
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43889715
125response to misfolded protein (GO:0051788)2.42910817
126gluconeogenesis (GO:0006094)2.42210480
127regulation of metalloenzyme activity (GO:0048552)2.41828701
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.41505283
129* antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.40742309
130peptidyl-arginine N-methylation (GO:0035246)2.40244452
131peptidyl-arginine methylation (GO:0018216)2.40244452
132purine nucleotide salvage (GO:0032261)2.40162872
133prostanoid biosynthetic process (GO:0046457)2.39909517
134prostaglandin biosynthetic process (GO:0001516)2.39909517
135protein autoprocessing (GO:0016540)2.39585802
136viral protein processing (GO:0019082)2.38529257
137basement membrane organization (GO:0071711)2.35430481
138pyrimidine-containing compound salvage (GO:0008655)2.33370840
139pyrimidine nucleoside salvage (GO:0043097)2.33370840
1402-deoxyribonucleotide biosynthetic process (GO:0009265)2.33080567
141deoxyribose phosphate biosynthetic process (GO:0046385)2.33080567
142glycolipid catabolic process (GO:0019377)2.31575496
143maintenance of protein localization in organelle (GO:0072595)2.31415728
144protein targeting to plasma membrane (GO:0072661)2.31180974
145activation of Rac GTPase activity (GO:0032863)2.30206066
146regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.29742946
147positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.29404673
148regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.29404673
149regulation of superoxide anion generation (GO:0032928)2.28873185
150positive regulation of receptor recycling (GO:0001921)2.28713108
151* regulation of defense response to virus by virus (GO:0050690)2.28246814
152glutamine family amino acid biosynthetic process (GO:0009084)2.27188194
153regulation of pseudopodium assembly (GO:0031272)2.26747556
154transferrin transport (GO:0033572)2.26732111
155negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.25659742
156membrane protein intracellular domain proteolysis (GO:0031293)2.24266403
157NIK/NF-kappaB signaling (GO:0038061)2.24078228
158adherens junction assembly (GO:0034333)2.24020914
159desmosome organization (GO:0002934)2.22502876
160* Golgi transport vesicle coating (GO:0048200)10.4719191
161* COPI coating of Golgi vesicle (GO:0048205)10.4719191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.34553467
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.50117596
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69602791
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68590688
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.65114540
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62107955
7MYC_22102868_ChIP-Seq_BL_Human2.40105310
8CLOCK_20551151_ChIP-Seq_293T_Human2.27152455
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.10689340
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04888205
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04111500
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.01576858
13* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99688704
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98855779
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97387823
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88685985
17ATF3_27146783_Chip-Seq_COLON_Human1.87514362
18* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.86364735
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86234382
20* GABP_19822575_ChIP-Seq_HepG2_Human1.86092876
21XRN2_22483619_ChIP-Seq_HELA_Human1.83314777
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79620135
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.79034231
24* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78656161
25E2F7_22180533_ChIP-Seq_HELA_Human1.77076361
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.76584348
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75695582
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74567230
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74427520
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71241216
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71234286
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67723333
33TFEB_21752829_ChIP-Seq_HELA_Human1.66739629
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66257746
35AR_21909140_ChIP-Seq_LNCAP_Human1.63157262
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62025509
37ZNF263_19887448_ChIP-Seq_K562_Human1.60439453
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58638304
39* LXR_22292898_ChIP-Seq_THP-1_Human1.58607436
40DCP1A_22483619_ChIP-Seq_HELA_Human1.58094627
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.57763954
42* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.53966203
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.50648494
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50031833
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47380347
46CIITA_25753668_ChIP-Seq_RAJI_Human1.46972293
47* TET1_21451524_ChIP-Seq_MESCs_Mouse1.44985305
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44849133
49* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42101917
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41781286
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41181799
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41179156
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39580908
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.39007453
55* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38537962
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37941300
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36766311
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34715054
59* VDR_21846776_ChIP-Seq_THP-1_Human1.34574242
60TCF7_22412390_ChIP-Seq_EML_Mouse1.34093403
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33759063
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33023392
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32932530
64KDM5A_27292631_Chip-Seq_BREAST_Human1.30984079
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30123886
66NCOR1_26117541_ChIP-Seq_K562_Human1.29080793
67KDM2B_26808549_Chip-Seq_DND41_Human1.28824279
68* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28469701
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28420003
70* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27931210
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26709801
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26450079
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26291591
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24536542
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24169865
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22995668
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22332329
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20501410
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20213609
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19761344
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19147118
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.18694033
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18558971
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17699885
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17656943
86* P68_20966046_ChIP-Seq_HELA_Human1.17654612
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17454725
88TTF2_22483619_ChIP-Seq_HELA_Human1.14889412
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14882177
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14836477
91* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14719391
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14281632
93* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12951918
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12518092
95* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12368791
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12078119
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10202000
98* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09889384
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.09317215
100VDR_23849224_ChIP-Seq_CD4+_Human1.09113563
101* CHD1_26751641_Chip-Seq_LNCaP_Human1.09026928
102* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08727041
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07728521
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06683731
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06502548
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06299995
107* ELF1_20517297_ChIP-Seq_JURKAT_Human1.06156917
108* MAF_26560356_Chip-Seq_TH1_Human1.05884822
109UTX_26944678_Chip-Seq_JUKART_Human1.03431779
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02550141
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02530524
112* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01531491
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01279537
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01011458
115* VDR_24763502_ChIP-Seq_THP-1_Human1.00901049
116* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00643418
117BCOR_27268052_Chip-Seq_Bcells_Human1.00299327
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00145523
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99830519
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99827412
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99508161
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99047638
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98870717
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.98652432
125* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97974647
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97834761
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97542785
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96942629
129* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96797025
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96793286
131FOXP3_21729870_ChIP-Seq_TREG_Human0.96783284
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96351496
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95354991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.69316825
2MP0005451_abnormal_body_composition3.47367291
3MP0008260_abnormal_autophagy3.41834344
4MP0010234_abnormal_vibrissa_follicle3.29156878
5MP0003705_abnormal_hypodermis_morpholog3.23993493
6MP0000013_abnormal_adipose_tissue3.09485161
7MP0010352_gastrointestinal_tract_polyps3.06299213
8MP0002877_abnormal_melanocyte_morpholog2.96200202
9MP0003123_paternal_imprinting2.91672243
10MP0002909_abnormal_adrenal_gland2.86029547
11MP0003283_abnormal_digestive_organ2.77115876
12MP0003693_abnormal_embryo_hatching2.76018854
13MP0009780_abnormal_chondrocyte_physiolo2.74618322
14MP0003191_abnormal_cellular_cholesterol2.71807148
15MP0005464_abnormal_platelet_physiology2.39400015
16MP0004957_abnormal_blastocyst_morpholog2.27255107
17MP0004264_abnormal_extraembryonic_tissu2.26168496
18MP0003183_abnormal_peptide_metabolism2.17512424
19MP0003566_abnormal_cell_adhesion2.13030068
20MP0004233_abnormal_muscle_weight1.97092074
21MP0003300_gastrointestinal_ulcer1.95303979
22MP0003436_decreased_susceptibility_to1.89403312
23MP0005501_abnormal_skin_physiology1.89366044
24MP0003122_maternal_imprinting1.88341186
25MP0003806_abnormal_nucleotide_metabolis1.83782158
26MP0002796_impaired_skin_barrier1.83086428
27MP0005076_abnormal_cell_differentiation1.79301526
28MP0001944_abnormal_pancreas_morphology1.76025950
29MP0005058_abnormal_lysosome_morphology1.69961066
30MP0009840_abnormal_foam_cell1.69614137
31MP0010386_abnormal_urinary_bladder1.66781399
32MP0001849_ear_inflammation1.61557750
33MP0001730_embryonic_growth_arrest1.61205882
34MP0000003_abnormal_adipose_tissue1.60850416
35MP0009278_abnormal_bone_marrow1.59059369
36MP0003453_abnormal_keratinocyte_physiol1.57980889
37MP0002693_abnormal_pancreas_physiology1.55846810
38MP0000537_abnormal_urethra_morphology1.54362780
39MP0005220_abnormal_exocrine_pancreas1.52600488
40MP0004782_abnormal_surfactant_physiolog1.50875392
41MP0008438_abnormal_cutaneous_collagen1.47057318
42MP0003221_abnormal_cardiomyocyte_apopto1.44666748
43MP0000358_abnormal_cell_content/1.44070037
44MP0002089_abnormal_postnatal_growth/wei1.43146515
45MP0000678_abnormal_parathyroid_gland1.41412249
46MP0005083_abnormal_biliary_tract1.37723827
47MP0004272_abnormal_basement_membrane1.35580829
48MP0002896_abnormal_bone_mineralization1.35531662
49MP0004510_myositis1.35384267
50MP0004858_abnormal_nervous_system1.34518347
51MP0001756_abnormal_urination1.33348785
52MP0004084_abnormal_cardiac_muscle1.31378326
53MP0004043_abnormal_pH_regulation1.31228612
54MP0008961_abnormal_basal_metabolism1.30502496
55MP0005623_abnormal_meninges_morphology1.30128774
56MP0003119_abnormal_digestive_system1.27287293
57MP0005023_abnormal_wound_healing1.26916531
58MP0001727_abnormal_embryo_implantation1.25214279
59MP0002234_abnormal_pharynx_morphology1.22437285
60MP0004859_abnormal_synaptic_plasticity1.21545922
61MP0002060_abnormal_skin_morphology1.21332902
62MP0002653_abnormal_ependyma_morphology1.21198047
63MP0003329_amyloid_beta_deposits1.20234158
64MP0003075_altered_response_to1.19306344
65MP0005165_increased_susceptibility_to1.18509266
66MP0001697_abnormal_embryo_size1.16745648
67MP0000681_abnormal_thyroid_gland1.15798223
68MP0002837_dystrophic_cardiac_calcinosis1.15247760
69MP0002080_prenatal_lethality1.14890040
70MP0000858_altered_metastatic_potential1.14690911
71MP0005257_abnormal_intraocular_pressure1.14046871
72MP0003656_abnormal_erythrocyte_physiolo1.12665397
73MP0002269_muscular_atrophy1.12562833
74MP0005275_abnormal_skin_tensile1.12388967
75MP0000465_gastrointestinal_hemorrhage1.11990025
76MP0009643_abnormal_urine_homeostasis1.11791856
77MP0003303_peritoneal_inflammation1.10860352
78MP0001765_abnormal_ion_homeostasis1.05705597
79MP0005187_abnormal_penis_morphology1.05413876
80MP0001216_abnormal_epidermal_layer1.04185427
81MP0002132_abnormal_respiratory_system0.99166692
82MP0000350_abnormal_cell_proliferation0.98874243
83MP0005375_adipose_tissue_phenotype0.98364655
84MP0009931_abnormal_skin_appearance0.98096211
85MP0003186_abnormal_redox_activity0.97497453
86MP0001881_abnormal_mammary_gland0.92178906
87MP0003172_abnormal_lysosome_physiology0.91656258
88MP0003866_abnormal_defecation0.90807695
89MP0003077_abnormal_cell_cycle0.90454079
90MP0002078_abnormal_glucose_homeostasis0.89623724
91MP0005384_cellular_phenotype0.88191020
92MP0010155_abnormal_intestine_physiology0.88169424
93MP0001243_abnormal_dermal_layer0.87976526
94MP0001958_emphysema0.87624113
95MP0003984_embryonic_growth_retardation0.87548041
96MP0002088_abnormal_embryonic_growth/wei0.87316773
97MP0010307_abnormal_tumor_latency0.87035967
98MP0005621_abnormal_cell_physiology0.86846822
99MP0001853_heart_inflammation0.86072625
100MP0005397_hematopoietic_system_phenotyp0.85424008
101MP0001545_abnormal_hematopoietic_system0.85424008
102MP0000534_abnormal_ureter_morphology0.84682989
103MP0000750_abnormal_muscle_regeneration0.83784609
104MP0001533_abnormal_skeleton_physiology0.83296727
105MP0000313_abnormal_cell_death0.83010725
106MP0008874_decreased_physiological_sensi0.82158755
107MP0002086_abnormal_extraembryonic_tissu0.81995402
108MP0000490_abnormal_crypts_of0.81338355
109MP0008007_abnormal_cellular_replicative0.80636541
110MP0002084_abnormal_developmental_patter0.79768601
111MP0000343_altered_response_to0.79111051
112MP0002098_abnormal_vibrissa_morphology0.78762327
113MP0002148_abnormal_hypersensitivity_rea0.77027924
114MP0003091_abnormal_cell_migration0.76733915
115MP0008004_abnormal_stomach_pH0.76019081
116MP0004197_abnormal_fetal_growth/weight/0.75754540
117MP0005166_decreased_susceptibility_to0.75744832
118MP0005380_embryogenesis_phenotype0.74749051
119MP0001672_abnormal_embryogenesis/_devel0.74749051
120MP0005025_abnormal_response_to0.74312255
121MP0005084_abnormal_gallbladder_morpholo0.74151306
122MP0006036_abnormal_mitochondrial_physio0.73262286
123MP0003724_increased_susceptibility_to0.72706030
124MP0003111_abnormal_nucleus_morphology0.72673342
125MP0000467_abnormal_esophagus_morphology0.72669736
126MP0003828_pulmonary_edema0.72307783
127MP0002085_abnormal_embryonic_tissue0.71754754
128MP0010771_integument_phenotype0.71018337
129MP0002419_abnormal_innate_immunity0.70980634
130MP0003279_aneurysm0.70612457
131MP0000477_abnormal_intestine_morphology0.69890366
132MP0005409_darkened_coat_color0.69791460
133MP0005666_abnormal_adipose_tissue0.69664704
134MP0009053_abnormal_anal_canal0.69028783
135MP0003795_abnormal_bone_structure0.68111522
136MP0000751_myopathy0.67190805
137MP0003448_altered_tumor_morphology0.67150444
138MP0008932_abnormal_embryonic_tissue0.66990408
139MP0002970_abnormal_white_adipose0.66726522
140MP0009672_abnormal_birth_weight0.66665249
141MP0009333_abnormal_splenocyte_physiolog0.66557721
142MP0001915_intracranial_hemorrhage0.66069862
143MP0000747_muscle_weakness0.65964534
144MP0004808_abnormal_hematopoietic_stem0.65826302
145MP0005167_abnormal_blood-brain_barrier0.64720739
146MP0000462_abnormal_digestive_system0.64578793
147MP0004087_abnormal_muscle_fiber0.63106648
148MP0004947_skin_inflammation0.62949142
149MP0000604_amyloidosis0.62933241
150MP0003121_genomic_imprinting0.62822110
151MP0010368_abnormal_lymphatic_system0.62592395

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)4.99396231
2Cholecystitis (HP:0001082)4.99396231
3Protrusio acetabuli (HP:0003179)3.33025813
4Distal lower limb amyotrophy (HP:0008944)3.25077633
5Abnormality of the anterior horn cell (HP:0006802)3.23176040
6Degeneration of anterior horn cells (HP:0002398)3.23176040
7Cerebral aneurysm (HP:0004944)3.07770115
8Upper limb muscle weakness (HP:0003484)3.06202176
9Petechiae (HP:0000967)3.03244080
10Hand muscle atrophy (HP:0009130)2.99616612
11Hypercortisolism (HP:0001578)2.97828540
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91578598
13Hypoglycemic coma (HP:0001325)2.89805815
14Distal lower limb muscle weakness (HP:0009053)2.86626105
15Hyperacusis (HP:0010780)2.84916471
16Limb-girdle muscle atrophy (HP:0003797)2.72518855
17Cervical subluxation (HP:0003308)2.71514328
18Ragged-red muscle fibers (HP:0003200)2.70903297
19Achilles tendon contracture (HP:0001771)2.69136232
20Mucopolysacchariduria (HP:0008155)2.65603735
21Urinary glycosaminoglycan excretion (HP:0003541)2.65603735
22Shoulder girdle muscle weakness (HP:0003547)2.61313479
23Neoplasm of the adrenal gland (HP:0100631)2.60632934
24Cholelithiasis (HP:0001081)2.55917680
25Pheochromocytoma (HP:0002666)2.54960367
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.52125289
27Abnormality of the Achilles tendon (HP:0005109)2.52087375
28Upper limb amyotrophy (HP:0009129)2.51209802
29Distal upper limb amyotrophy (HP:0007149)2.51209802
30Striae distensae (HP:0001065)2.50020852
31J-shaped sella turcica (HP:0002680)2.49267274
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.46588622
33Angiofibromas (HP:0010615)2.46263065
34Adenoma sebaceum (HP:0009720)2.46263065
35Neuroendocrine neoplasm (HP:0100634)2.44832863
36Dysostosis multiplex (HP:0000943)2.44453975
37Growth hormone excess (HP:0000845)2.43727050
38Long toe (HP:0010511)2.43711391
39Pelvic girdle muscle weakness (HP:0003749)2.43473819
40Late onset (HP:0003584)2.43154599
41Purpura (HP:0000979)2.40350323
42Loss of speech (HP:0002371)2.39899635
43Aortic aneurysm (HP:0004942)2.39169495
44Conjunctival hamartoma (HP:0100780)2.37235982
45Abnormality of the distal phalanges of the toes (HP:0010182)2.34867221
46Increased cerebral lipofuscin (HP:0011813)2.34254265
47Abnormality of glycolysis (HP:0004366)2.34229755
48Hypoglycemic seizures (HP:0002173)2.33953564
49Abnormality of polysaccharide metabolism (HP:0011012)2.33328193
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33328193
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33328193
52Insomnia (HP:0100785)2.31352599
53Lower limb amyotrophy (HP:0007210)2.29706194
54Menorrhagia (HP:0000132)2.27333897
55Abnormal pancreas size (HP:0012094)2.27282194
56Gout (HP:0001997)2.27263870
57Dilatation of the ascending aorta (HP:0005111)2.26809899
58Hypokinesia (HP:0002375)2.26125373
59Neoplasm of the peripheral nervous system (HP:0100007)2.25799886
60Interstitial pulmonary disease (HP:0006530)2.23490463
61Hyperinsulinemic hypoglycemia (HP:0000825)2.23262867
62Ketoacidosis (HP:0001993)2.22269785
63Reticulocytosis (HP:0001923)2.22196971
64Increased connective tissue (HP:0009025)2.22016520
65Abnormal gallbladder morphology (HP:0012437)2.21454310
66Hypoplasia of the pons (HP:0012110)2.21416455
67Hypertensive crisis (HP:0100735)2.18502248
68Aneurysm (HP:0002617)2.18353524
69Right ventricular cardiomyopathy (HP:0011663)2.17034525
70Palpitations (HP:0001962)2.16231999
71Multiple enchondromatosis (HP:0005701)2.12522160
72Abnormality of the gallbladder (HP:0005264)2.10999032
73Difficulty climbing stairs (HP:0003551)2.08256266
74Vacuolated lymphocytes (HP:0001922)2.07356792
75Ankle contracture (HP:0006466)2.07122455
76Neuronal loss in central nervous system (HP:0002529)2.05580047
77Enlarged penis (HP:0000040)2.05575461
78Diminished motivation (HP:0000745)2.05250557
79Fasciculations (HP:0002380)2.04961534
80Myopathic facies (HP:0002058)2.03310452
81Abnormality of the musculature of the pelvis (HP:0001469)2.02511758
82Abnormality of the hip-girdle musculature (HP:0001445)2.02511758
83Deep palmar crease (HP:0006191)2.01453073
84Vertebral compression fractures (HP:0002953)2.01030633
85Long palpebral fissure (HP:0000637)2.00401050
86Increased mean platelet volume (HP:0011877)1.97900736
87Shallow orbits (HP:0000586)1.97321308
88Hyperglycemia (HP:0003074)1.96831474
89Truncus arteriosus (HP:0001660)1.96675348
90Abnormal neuron morphology (HP:0012757)1.95365053
91Abnormality of the motor neurons (HP:0002450)1.95365053
92Trismus (HP:0000211)1.94814542
93Micronodular cirrhosis (HP:0001413)1.94770945
94Severe short stature (HP:0003510)1.94503977
95Spinal canal stenosis (HP:0003416)1.92611026
96Abnormality of the umbilical cord (HP:0010881)1.92575316
97Apathy (HP:0000741)1.92458301
98Abnormal platelet volume (HP:0011876)1.92368008
99Hyperparathyroidism (HP:0000843)1.88900757
100Osteopenia (HP:0000938)1.88851775
101Visual hallucinations (HP:0002367)1.86622757
102Impaired platelet aggregation (HP:0003540)1.85679825
103Abnormal platelet function (HP:0011869)1.85679825
104Aortic dissection (HP:0002647)1.84520233
105Insulin resistance (HP:0000855)1.84399367
106Back pain (HP:0003418)1.84190277
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.84184531
108Abnormality of the pancreatic islet cells (HP:0006476)1.84006602
109Abnormality of endocrine pancreas physiology (HP:0012093)1.84006602
110Supranuclear gaze palsy (HP:0000605)1.83763572
111Athetosis (HP:0002305)1.83474475
112Spinal rigidity (HP:0003306)1.83461635
113Agitation (HP:0000713)1.83165255
114Intestinal polyposis (HP:0200008)1.82692061
115Hepatosplenomegaly (HP:0001433)1.82583685
116Microretrognathia (HP:0000308)1.82211032
117Axonal loss (HP:0003447)1.82109758
118Spinal muscular atrophy (HP:0007269)1.82094777
119Unilateral renal agenesis (HP:0000122)1.81685904
120Fatigue (HP:0012378)1.81145999
121Abnormality of macrophages (HP:0004311)1.81110416
122Distal sensory impairment (HP:0002936)1.80434813
123Premature rupture of membranes (HP:0001788)1.80411694
124Prominent metopic ridge (HP:0005487)1.80208415
125Polycythemia (HP:0001901)1.79023970
126Hydroureter (HP:0000072)1.78314693
127Thin bony cortex (HP:0002753)1.78103474
128Atelectasis (HP:0100750)1.78065843
129Rough bone trabeculation (HP:0100670)1.77190596
130Slender long bone (HP:0003100)1.76547059
131Thoracolumbar scoliosis (HP:0002944)1.74964565
132Postnatal microcephaly (HP:0005484)1.74360756
133Orthostatic hypotension (HP:0001278)1.73817528
134Intestinal polyp (HP:0005266)1.73664944
135Stridor (HP:0010307)1.71877005
136Hyperthyroidism (HP:0000836)1.71422690
137Ulnar deviation of the wrist (HP:0003049)1.71175540
138Poor head control (HP:0002421)1.71155395
139Resting tremor (HP:0002322)1.71061513
140Hammertoe (HP:0001765)1.71058083
141Seborrheic dermatitis (HP:0001051)1.70142574
142Nuclear cataract (HP:0100018)1.69802880
143Joint stiffness (HP:0001387)1.69660116
144Increased density of long bones (HP:0006392)1.69148670
145Abnormality of liposaccharide metabolism (HP:0010968)1.67729956
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.67729956
147Abnormality of glycolipid metabolism (HP:0010969)1.67729956
148Increased serum pyruvate (HP:0003542)1.67159933
149Adrenal overactivity (HP:0002717)1.66775021
150Hyperactive renin-angiotensin system (HP:0000841)1.66180306
151Cerebral inclusion bodies (HP:0100314)1.66131681
152Peritonitis (HP:0002586)1.65588294
153Beaking of vertebral bodies (HP:0004568)1.65473612
154Prolonged bleeding time (HP:0003010)1.64940021
155Symptomatic seizures (HP:0011145)1.64797923
156Polygenic inheritance (HP:0010982)1.64622557
157Tongue fasciculations (HP:0001308)1.64548356
158Progressive neurologic deterioration (HP:0002344)1.64511535
159Gastrointestinal dysmotility (HP:0002579)1.64474367
160Bone pain (HP:0002653)1.64132415
161Sparse lateral eyebrow (HP:0005338)1.63346801
162Hemorrhage of the eye (HP:0011885)1.62029169
163Broad face (HP:0000283)1.61654974
164Ankle clonus (HP:0011448)1.61586254
165Tetraparesis (HP:0002273)1.61468521
166Mildly elevated creatine phosphokinase (HP:0008180)1.61434656
167Single umbilical artery (HP:0001195)1.60617945
168Abnormality of the fetal cardiovascular system (HP:0010948)1.60617945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.15676260
2TESK13.57155613
3NEK13.14547467
4IRAK33.01593157
5ERN12.95676569
6SCYL22.92375840
7KSR22.91670289
8PKN22.82201754
9PRPF4B2.61708164
10PASK2.52576458
11TESK22.15174283
12SIK32.10045840
13ARAF2.06474989
14LIMK12.06108493
15SMG12.03751378
16EPHA21.91294270
17EEF2K1.86507511
18BUB11.78041685
19MAP3K91.77789028
20ICK1.77530850
21PAK41.76893339
22TAOK11.63152164
23MAP3K21.59798629
24MAP3K111.59379367
25SIK11.56711202
26MAP3K121.55034534
27PRKD31.54586041
28TSSK61.54476062
29LRRK21.53857937
30MAPKAPK31.51864788
31EPHB11.49309768
32KSR11.40009943
33RAF11.39689741
34FLT31.38928691
35DAPK11.37397164
36MST1R1.35984748
37KDR1.32434940
38RPS6KA41.28946466
39CDK121.26488230
40FER1.25469007
41BRAF1.24540603
42PTK21.20310298
43ILK1.18191763
44EIF2AK11.18185987
45MAP3K31.17959813
46RIPK11.17429067
47MAP3K11.16589729
48PTK61.13329688
49MAP3K101.12052403
50MAP2K11.11779528
51CCNB11.11132356
52LATS21.06369531
53TGFBR11.05662921
54MINK11.01598352
55MAP3K81.01037455
56BRSK10.94937509
57CAMKK10.94075003
58BMX0.91163196
59RIPK40.90982139
60ZAP700.88144765
61MOS0.87565634
62PDGFRA0.87264604
63MAP2K30.86732906
64WEE10.86684508
65TTN0.85759459
66LMTK20.83786547
67PAK30.83396237
68BRSK20.77869887
69MYLK0.76968580
70NTRK10.76101849
71PRKD20.75478922
72CAMKK20.74423872
73EPHA30.73635743
74PAK10.73155347
75PDK20.72134405
76MAP2K20.69587813
77RET0.69285078
78RPS6KB20.67978228
79CDK140.67946835
80PDPK10.67891181
81STK100.67073775
82FGFR40.66683166
83ABL20.65626564
84NME10.65289692
85NEK20.64023960
86PIM20.62102965
87BCKDK0.61112722
88STK380.59856251
89IRAK20.58332385
90TAOK20.57706635
91MST40.57609140
92AKT20.55375387
93PRKCI0.55156557
94PTK2B0.55146041
95CDK180.54698367
96MAP3K50.54542361
97MTOR0.54353521
98MAP3K130.53825903
99EIF2AK30.53269244
100CDK150.52310605
101MAP3K60.52078889
102CLK10.50956268
103DAPK20.49925180
104PAK60.49421689
105VRK20.48814032
106PLK20.48709051
107MAP3K140.48704437
108PAK20.48348580
109CDK11A0.47958434
110CDK70.47845548
111NTRK30.47594423
112NME20.46902920
113ALK0.46395235
114FRK0.45949404
115GRK60.45210702
116CSNK1G30.43913372
117DAPK30.43053702
118FGFR10.42933350
119TRIM280.42584481
120AURKA0.42535526
121CDK190.41417366
122CDC70.40814291
123ERBB30.40708330
124MET0.40561551
125PDK30.40026888
126PDK40.40026888
127MAPKAPK20.39405341
128MARK20.38916455
129TBK10.37879285
130NEK90.37483733
131DDR20.36396386
132HIPK20.34778070
133PRKG20.34567397
134MAPK110.34544696
135PRKD10.34399205
136CDC42BPA0.33964555

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.36981994
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.93963330
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.92418678
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.59043064
5* Vibrio cholerae infection_Homo sapiens_hsa051102.54894984
6Proteasome_Homo sapiens_hsa030502.40464851
7Protein export_Homo sapiens_hsa030602.38264835
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29813018
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.15334566
10N-Glycan biosynthesis_Homo sapiens_hsa005102.06095977
11Synaptic vesicle cycle_Homo sapiens_hsa047211.92762271
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87983006
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85010404
14Sulfur relay system_Homo sapiens_hsa041221.74758877
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.73985254
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.73196075
17Fatty acid elongation_Homo sapiens_hsa000621.62725939
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56279634
19Shigellosis_Homo sapiens_hsa051311.54248404
20Lysosome_Homo sapiens_hsa041421.53531586
21Bladder cancer_Homo sapiens_hsa052191.41321486
22Galactose metabolism_Homo sapiens_hsa000521.38345702
23Collecting duct acid secretion_Homo sapiens_hsa049661.33071712
24Acute myeloid leukemia_Homo sapiens_hsa052211.32147483
25Carbon metabolism_Homo sapiens_hsa012001.30147563
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27574737
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25370649
28Thyroid cancer_Homo sapiens_hsa052161.24889180
29Oocyte meiosis_Homo sapiens_hsa041141.20781328
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18530325
31* Legionellosis_Homo sapiens_hsa051341.16651656
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16092051
33Insulin secretion_Homo sapiens_hsa049111.12904021
34Biosynthesis of amino acids_Homo sapiens_hsa012301.11088982
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.10418163
36RNA transport_Homo sapiens_hsa030131.08656249
37Long-term potentiation_Homo sapiens_hsa047201.06000656
38Glutathione metabolism_Homo sapiens_hsa004801.02839072
39DNA replication_Homo sapiens_hsa030301.01662809
40VEGF signaling pathway_Homo sapiens_hsa043701.01164518
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.99849450
42mTOR signaling pathway_Homo sapiens_hsa041500.97228309
43Phagosome_Homo sapiens_hsa041450.95781892
44Cell cycle_Homo sapiens_hsa041100.93730506
45Colorectal cancer_Homo sapiens_hsa052100.92862057
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91658354
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88451151
48Chronic myeloid leukemia_Homo sapiens_hsa052200.88154564
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.86920703
50Antigen processing and presentation_Homo sapiens_hsa046120.86687711
51Hepatitis C_Homo sapiens_hsa051600.85755230
52Estrogen signaling pathway_Homo sapiens_hsa049150.85672224
53Fructose and mannose metabolism_Homo sapiens_hsa000510.84888430
54Arginine and proline metabolism_Homo sapiens_hsa003300.84798734
55Glioma_Homo sapiens_hsa052140.84753624
56Phenylalanine metabolism_Homo sapiens_hsa003600.82231385
57Amphetamine addiction_Homo sapiens_hsa050310.81913364
58Thyroid hormone synthesis_Homo sapiens_hsa049180.80336870
59AMPK signaling pathway_Homo sapiens_hsa041520.80255733
60Renin-angiotensin system_Homo sapiens_hsa046140.79469385
61Sphingolipid metabolism_Homo sapiens_hsa006000.78698637
62Pancreatic cancer_Homo sapiens_hsa052120.78675623
63Adherens junction_Homo sapiens_hsa045200.78305646
64Endometrial cancer_Homo sapiens_hsa052130.77421965
65Type I diabetes mellitus_Homo sapiens_hsa049400.76489237
66* Endocytosis_Homo sapiens_hsa041440.76240183
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75794463
68Pentose phosphate pathway_Homo sapiens_hsa000300.74833301
69Folate biosynthesis_Homo sapiens_hsa007900.73708089
70Dopaminergic synapse_Homo sapiens_hsa047280.72903954
71Gap junction_Homo sapiens_hsa045400.72808777
72Insulin signaling pathway_Homo sapiens_hsa049100.72456338
73Prion diseases_Homo sapiens_hsa050200.71660897
74HIF-1 signaling pathway_Homo sapiens_hsa040660.70608683
75Selenocompound metabolism_Homo sapiens_hsa004500.69328844
76Focal adhesion_Homo sapiens_hsa045100.69066873
77Type II diabetes mellitus_Homo sapiens_hsa049300.67415994
78Hippo signaling pathway_Homo sapiens_hsa043900.66747512
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66643033
80Salmonella infection_Homo sapiens_hsa051320.66370872
81Renal cell carcinoma_Homo sapiens_hsa052110.65235333
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.64484037
83Proteoglycans in cancer_Homo sapiens_hsa052050.64410716
84Cocaine addiction_Homo sapiens_hsa050300.62427619
85Glucagon signaling pathway_Homo sapiens_hsa049220.62014336
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60490059
87Arginine biosynthesis_Homo sapiens_hsa002200.60388357
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59777822
89Prolactin signaling pathway_Homo sapiens_hsa049170.58814373
90Pyruvate metabolism_Homo sapiens_hsa006200.58252278
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56771697
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56722816
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.55836561
94Apoptosis_Homo sapiens_hsa042100.55432941
95Insulin resistance_Homo sapiens_hsa049310.55274196
96Osteoclast differentiation_Homo sapiens_hsa043800.54773092
97Other glycan degradation_Homo sapiens_hsa005110.54427100
98Base excision repair_Homo sapiens_hsa034100.53833064
99p53 signaling pathway_Homo sapiens_hsa041150.52999985
100Amoebiasis_Homo sapiens_hsa051460.52722994
101Sulfur metabolism_Homo sapiens_hsa009200.52434802
102Notch signaling pathway_Homo sapiens_hsa043300.52323394
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52273179
104Tight junction_Homo sapiens_hsa045300.52269474
105Non-small cell lung cancer_Homo sapiens_hsa052230.51892298
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51725131
107Epstein-Barr virus infection_Homo sapiens_hsa051690.51144328
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50931840
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50715556
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50506906
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.50440978
112TNF signaling pathway_Homo sapiens_hsa046680.49927110
113Pertussis_Homo sapiens_hsa051330.49342058
114GnRH signaling pathway_Homo sapiens_hsa049120.49143575
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47422688
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46468335
117Viral carcinogenesis_Homo sapiens_hsa052030.45806703
118Pyrimidine metabolism_Homo sapiens_hsa002400.45647597
119Hepatitis B_Homo sapiens_hsa051610.45611423
120HTLV-I infection_Homo sapiens_hsa051660.45183682
121Spliceosome_Homo sapiens_hsa030400.44377647
122Influenza A_Homo sapiens_hsa051640.43597314
123Vitamin B6 metabolism_Homo sapiens_hsa007500.42900857
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42459963
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41974353
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40368472
127Tuberculosis_Homo sapiens_hsa051520.39836327
128ErbB signaling pathway_Homo sapiens_hsa040120.39414473
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38181693
130B cell receptor signaling pathway_Homo sapiens_hsa046620.36700749
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35000401
132Herpes simplex infection_Homo sapiens_hsa051680.34079981
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.32719709
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32683720
135Steroid biosynthesis_Homo sapiens_hsa001000.29846211
136Viral myocarditis_Homo sapiens_hsa054160.29672970

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