ARF1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.39378307
2glucosamine-containing compound catabolic process (GO:1901072)5.74332079
3response to nitrosative stress (GO:0051409)5.47255401
4negative regulation of T cell differentiation in thymus (GO:0033085)5.45474136
5response to xenobiotic stimulus (GO:0009410)5.43635780
6regulation of telomere maintenance via telomerase (GO:0032210)5.32119787
7regulation of gamma-delta T cell differentiation (GO:0045586)5.19934923
8sleep (GO:0030431)4.81869504
9RNA destabilization (GO:0050779)4.79152079
10negative T cell selection (GO:0043383)4.77427541
11positive regulation of T cell apoptotic process (GO:0070234)4.76522088
12cysteine metabolic process (GO:0006534)4.76460428
13regulation of gamma-delta T cell activation (GO:0046643)4.69062699
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.62504892
15regulation of B cell receptor signaling pathway (GO:0050855)4.49465598
16positive T cell selection (GO:0043368)4.43866642
17positive regulation of T cell differentiation in thymus (GO:0033089)4.43056296
18regulation of thymocyte apoptotic process (GO:0070243)4.37972416
19negative regulation of telomere maintenance (GO:0032205)4.27879806
20regulation of T cell differentiation in thymus (GO:0033081)4.19770242
21negative thymic T cell selection (GO:0045060)4.18936298
22cell wall macromolecule metabolic process (GO:0044036)4.13255010
23positive regulation of gamma-delta T cell activation (GO:0046645)4.13248932
24positive thymic T cell selection (GO:0045059)4.06727019
25regulation of isotype switching to IgG isotypes (GO:0048302)3.94838760
26mature B cell differentiation (GO:0002335)3.88993797
27ubiquinone biosynthetic process (GO:0006744)3.82123015
28cellular response to nicotine (GO:0071316)3.70817194
29positive regulation of lymphocyte apoptotic process (GO:0070230)3.67490226
30positive regulation of B cell differentiation (GO:0045579)3.56469690
31positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55207372
32regulation of mitochondrial depolarization (GO:0051900)3.48654930
33negative regulation of necroptotic process (GO:0060546)3.40502005
34dopamine biosynthetic process (GO:0042416)3.38011852
35amino sugar catabolic process (GO:0046348)3.31931632
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31867520
37ubiquinone metabolic process (GO:0006743)3.30702646
38positive regulation of T-helper 1 type immune response (GO:0002827)3.29946648
39mature B cell differentiation involved in immune response (GO:0002313)3.29107922
40negative regulation of interleukin-1 beta production (GO:0032691)3.23812822
41T cell receptor signaling pathway (GO:0050852)3.21781492
42phosphatidylinositol dephosphorylation (GO:0046856)3.17285943
43quinone biosynthetic process (GO:1901663)3.13428946
44negative regulation of B cell mediated immunity (GO:0002713)3.11749169
45negative regulation of immunoglobulin mediated immune response (GO:0002890)3.11749169
46interferon-gamma production (GO:0032609)3.11125329
47L-ascorbic acid metabolic process (GO:0019852)3.09341236
48pyrimidine nucleobase catabolic process (GO:0006208)3.08387194
49thymic T cell selection (GO:0045061)3.07389252
50leukocyte aggregation (GO:0070486)3.05910063
51tachykinin receptor signaling pathway (GO:0007217)3.05106860
52regulation of activation of Janus kinase activity (GO:0010533)3.05043311
53mast cell activation involved in immune response (GO:0002279)3.03543815
54mast cell degranulation (GO:0043303)3.03543815
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02100648
56aspartate family amino acid catabolic process (GO:0009068)3.00356846
57positive regulation of RNA splicing (GO:0033120)2.99814333
58phospholipid dephosphorylation (GO:0046839)2.99641095
59grooming behavior (GO:0007625)2.98288637
60neuronal action potential (GO:0019228)2.97624005
61S-adenosylmethionine metabolic process (GO:0046500)2.96358994
62T cell selection (GO:0045058)2.91255559
63regulation of B cell differentiation (GO:0045577)2.90190809
64cytidine metabolic process (GO:0046087)2.89776364
65cytidine catabolic process (GO:0006216)2.89776364
66cytidine deamination (GO:0009972)2.89776364
67antigen receptor-mediated signaling pathway (GO:0050851)2.88934242
68T cell migration (GO:0072678)2.88139563
69nucleoside transmembrane transport (GO:1901642)2.87281810
70phosphorylated carbohydrate dephosphorylation (GO:0046838)2.87078051
71inositol phosphate dephosphorylation (GO:0046855)2.87078051
72mast cell activation (GO:0045576)2.86270037
73NIK/NF-kappaB signaling (GO:0038061)2.86043105
74DNA deamination (GO:0045006)2.84803499
75regulation of alpha-beta T cell proliferation (GO:0046640)2.84747165
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84291831
77DNA methylation involved in gamete generation (GO:0043046)2.83992370
78positive regulation of defense response to virus by host (GO:0002230)2.83737210
79negative regulation of interleukin-6 production (GO:0032715)2.81981354
80response to muramyl dipeptide (GO:0032495)2.81085077
81positive regulation of calcium-mediated signaling (GO:0050850)2.80428964
82positive regulation of leukocyte apoptotic process (GO:2000108)2.77258586
83neural tube formation (GO:0001841)2.75413288
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75313998
85negative regulation of necrotic cell death (GO:0060547)2.75137084
86actin nucleation (GO:0045010)2.74618376
87positive regulation of uterine smooth muscle contraction (GO:0070474)2.69563340
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68301817
89regulation of telomere maintenance (GO:0032204)2.68295955
90regulation of T cell apoptotic process (GO:0070232)2.67157395
91negative regulation of interleukin-1 production (GO:0032692)2.65568800
92behavioral response to nicotine (GO:0035095)2.65377401
93T cell costimulation (GO:0031295)2.64256420
94regulation of necroptotic process (GO:0060544)2.63785540
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62988534
96sequestering of actin monomers (GO:0042989)2.62602525
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61815915
98T-helper cell differentiation (GO:0042093)2.61059378
99CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61059378
100lymphocyte costimulation (GO:0031294)2.60902148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.57775533
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04731900
3GATA1_22025678_ChIP-Seq_K562_Human4.64403747
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.43523484
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.36512706
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.64135077
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57396145
8IGF1R_20145208_ChIP-Seq_DFB_Human3.24325433
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54930222
10RUNX_20019798_ChIP-Seq_JUKART_Human2.51072985
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40120581
12MYB_26560356_Chip-Seq_TH2_Human2.29560127
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04372544
14STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96849893
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86939195
16RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.77766142
17GATA3_26560356_Chip-Seq_TH2_Human1.77433529
18VDR_23849224_ChIP-Seq_CD4+_Human1.74533602
19TAF15_26573619_Chip-Seq_HEK293_Human1.68960824
20EWS_26573619_Chip-Seq_HEK293_Human1.68126280
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65757463
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63224162
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63154398
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62244024
25GATA3_27048872_Chip-Seq_THYMUS_Human1.61924276
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59402189
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56721740
28MYB_26560356_Chip-Seq_TH1_Human1.51518166
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51383200
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49056298
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40473156
32UTX_26944678_Chip-Seq_JUKART_Human1.38534191
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.34771290
34AR_21572438_ChIP-Seq_LNCaP_Human1.34138247
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30678529
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29235172
37ZNF274_21170338_ChIP-Seq_K562_Hela1.28934277
38P300_19829295_ChIP-Seq_ESCs_Human1.27616289
39MAF_26560356_Chip-Seq_TH1_Human1.22076581
40FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21536087
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19338146
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19307153
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18962680
44RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17884285
45VDR_22108803_ChIP-Seq_LS180_Human1.15704256
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15057258
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.14933184
48DROSHA_22980978_ChIP-Seq_HELA_Human1.14566068
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14551089
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13734078
51IRF1_19129219_ChIP-ChIP_H3396_Human1.10899895
52AR_20517297_ChIP-Seq_VCAP_Human1.10484651
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10436427
54MYC_18940864_ChIP-ChIP_HL60_Human1.07888181
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.07876510
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07276246
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.06491273
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06016400
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05392051
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04779604
61FOXH1_21741376_ChIP-Seq_ESCs_Human1.00874829
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00381207
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.00381207
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99583883
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98779426
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97581428
67EZH2_22144423_ChIP-Seq_EOC_Human0.96684027
68EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96096843
69SPI1_20517297_ChIP-Seq_HL60_Human0.94771984
70IRF8_21731497_ChIP-ChIP_J774_Mouse0.94621378
71PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94603127
72GATA3_26560356_Chip-Seq_TH1_Human0.94274010
73BCL6_27268052_Chip-Seq_Bcells_Human0.92798300
74PRDM14_20953172_ChIP-Seq_ESCs_Human0.92720332
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89436396
76HOXB7_26014856_ChIP-Seq_BT474_Human0.88077262
77FOXP3_21729870_ChIP-Seq_TREG_Human0.87628312
78ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87492971
79MAF_26560356_Chip-Seq_TH2_Human0.87017733
80FUS_26573619_Chip-Seq_HEK293_Human0.86485404
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86156327
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86018325
83GBX2_23144817_ChIP-Seq_PC3_Human0.85902800
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85866949
85MYC_19829295_ChIP-Seq_ESCs_Human0.84121164
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82797919
87CEBPB_22108803_ChIP-Seq_LS180_Human0.82582646
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82347373
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82332022
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82162149
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82099220
92SPI1_23547873_ChIP-Seq_NB4_Human0.81920871
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80683202
94CDX2_22108803_ChIP-Seq_LS180_Human0.79321403
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.79013844
96PHF8_20622854_ChIP-Seq_HELA_Human0.78778966
97LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.78627429
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78364165
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76826918
100ER_23166858_ChIP-Seq_MCF-7_Human0.76114406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.30654433
2MP0003763_abnormal_thymus_physiology3.25708509
3MP0003436_decreased_susceptibility_to3.18616520
4MP0005671_abnormal_response_to3.06792409
5MP0002166_altered_tumor_susceptibility3.06066188
6MP0001835_abnormal_antigen_presentation2.84492620
7MP0005423_abnormal_somatic_nervous2.66932238
8MP0006276_abnormal_autonomic_nervous2.64679915
9MP0003646_muscle_fatigue2.54388008
10MP0001800_abnormal_humoral_immune2.23681880
11MP0002006_tumorigenesis2.16960861
12MP0002405_respiratory_system_inflammati2.06075720
13MP0000685_abnormal_immune_system2.06009768
14MP0008877_abnormal_DNA_methylation2.05980188
15MP0001984_abnormal_olfaction2.01846310
16MP0002332_abnormal_exercise_endurance1.97363854
17MP0009764_decreased_sensitivity_to1.93979043
18MP0004145_abnormal_muscle_electrophysio1.84872487
19MP0005646_abnormal_pituitary_gland1.80824692
20MP0000750_abnormal_muscle_regeneration1.78265755
21MP0005000_abnormal_immune_tolerance1.77302598
22MP0000604_amyloidosis1.75985940
23MP0009785_altered_susceptibility_to1.75923045
24MP0002723_abnormal_immune_serum1.75533749
25MP0002452_abnormal_antigen_presenting1.71144757
26MP0005410_abnormal_fertilization1.70209184
27MP0003724_increased_susceptibility_to1.67703313
28MP0001440_abnormal_grooming_behavior1.64827516
29MP0000372_irregular_coat_pigmentation1.63570340
30MP0001986_abnormal_taste_sensitivity1.63457747
31MP0003252_abnormal_bile_duct1.56519564
32MP0004142_abnormal_muscle_tone1.56508594
33MP0000465_gastrointestinal_hemorrhage1.55416279
34MP0002420_abnormal_adaptive_immunity1.54366232
35MP0003122_maternal_imprinting1.54208436
36MP0001819_abnormal_immune_cell1.53967220
37MP0008872_abnormal_physiological_respon1.52709576
38MP0003806_abnormal_nucleotide_metabolis1.50553605
39MP0002933_joint_inflammation1.38307862
40MP0010155_abnormal_intestine_physiology1.35716431
41MP0001873_stomach_inflammation1.33215891
42MP0003329_amyloid_beta_deposits1.30579331
43MP0008961_abnormal_basal_metabolism1.29437967
44MP0002398_abnormal_bone_marrow1.25935182
45MP0001853_heart_inflammation1.23607205
46MP0002736_abnormal_nociception_after1.22462296
47MP0000716_abnormal_immune_system1.21851234
48MP0001968_abnormal_touch/_nociception1.20336971
49MP0005025_abnormal_response_to1.19115250
50MP0001502_abnormal_circadian_rhythm1.18999525
51MP0002419_abnormal_innate_immunity1.17470975
52MP0005266_abnormal_metabolism1.16966042
53MP0002876_abnormal_thyroid_physiology1.11864301
54MP0001501_abnormal_sleep_pattern1.09068151
55MP0003866_abnormal_defecation1.07847423
56MP0000703_abnormal_thymus_morphology1.05957561
57MP0003890_abnormal_embryonic-extraembry1.04142962
58MP0003635_abnormal_synaptic_transmissio1.01943620
59MP0005645_abnormal_hypothalamus_physiol1.01782434
60MP0001727_abnormal_embryo_implantation1.01130373
61MP0000689_abnormal_spleen_morphology1.00519668
62MP0003300_gastrointestinal_ulcer0.96830413
63MP0001845_abnormal_inflammatory_respons0.95719088
64MP0001790_abnormal_immune_system0.95633367
65MP0005387_immune_system_phenotype0.95633367
66MP0006072_abnormal_retinal_apoptosis0.95474612
67MP0001905_abnormal_dopamine_level0.94316287
68MP0003186_abnormal_redox_activity0.93814483
69MP0008469_abnormal_protein_level0.93482934
70MP0002557_abnormal_social/conspecific_i0.92666641
71MP0000569_abnormal_digit_pigmentation0.92165356
72MP0010368_abnormal_lymphatic_system0.92003254
73MP0005379_endocrine/exocrine_gland_phen0.90916508
74MP0005166_decreased_susceptibility_to0.89842687
75MP0002139_abnormal_hepatobiliary_system0.89561502
76MP0002733_abnormal_thermal_nociception0.88684705
77MP0002722_abnormal_immune_system0.87476849
78MP0002272_abnormal_nervous_system0.86492821
79MP0001533_abnormal_skeleton_physiology0.86188394
80MP0005365_abnormal_bile_salt0.85322057
81MP0008875_abnormal_xenobiotic_pharmacok0.84932492
82MP0003121_genomic_imprinting0.83068827
83MP0001970_abnormal_pain_threshold0.82435935
84MP0002429_abnormal_blood_cell0.81726314
85MP0002277_abnormal_respiratory_mucosa0.80986823
86MP0000230_abnormal_systemic_arterial0.79893347
87MP0002138_abnormal_hepatobiliary_system0.78498777
88MP0002269_muscular_atrophy0.77678429
89MP0005448_abnormal_energy_balance0.74180171
90MP0005084_abnormal_gallbladder_morpholo0.72859392
91MP0002067_abnormal_sensory_capabilities0.72765640
92MP0003828_pulmonary_edema0.72652519
93MP0008057_abnormal_DNA_replication0.71872317
94MP0001348_abnormal_lacrimal_gland0.71317003
95MP0002106_abnormal_muscle_physiology0.71009434
96MP0000955_abnormal_spinal_cord0.69865163
97MP0009745_abnormal_behavioral_response0.69620837
98MP0004947_skin_inflammation0.69560423
99MP0004264_abnormal_extraembryonic_tissu0.68997362
100MP0001765_abnormal_ion_homeostasis0.68455057

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)6.75590530
2Type II lissencephaly (HP:0007260)5.43062941
3Oral leukoplakia (HP:0002745)5.15857580
4Retinal dysplasia (HP:0007973)5.12508888
5Aplastic anemia (HP:0001915)5.03191822
6Amyotrophic lateral sclerosis (HP:0007354)4.55343137
7Stomatitis (HP:0010280)4.22971346
8IgG deficiency (HP:0004315)4.12655593
9Severe combined immunodeficiency (HP:0004430)4.05313290
10Elevated erythrocyte sedimentation rate (HP:0003565)3.94832185
11Hypoproteinemia (HP:0003075)3.92180122
12Renal Fanconi syndrome (HP:0001994)3.49466453
13Mesangial abnormality (HP:0001966)3.45354283
14Atrophy/Degeneration involving motor neurons (HP:0007373)3.35100175
15T lymphocytopenia (HP:0005403)3.22118997
16Fetal akinesia sequence (HP:0001989)3.17057648
17Combined immunodeficiency (HP:0005387)3.10644675
18Cheilitis (HP:0100825)3.00949848
19Hypoplasia of the thymus (HP:0000778)3.00617662
20Prostate neoplasm (HP:0100787)2.91495777
21Poikiloderma (HP:0001029)2.91158109
22Entropion (HP:0000621)2.90478198
23Fatigue (HP:0012378)2.80637216
24Stomach cancer (HP:0012126)2.78974452
25Popliteal pterygium (HP:0009756)2.76618903
26Thyroiditis (HP:0100646)2.75622196
27Abnormality of DNA repair (HP:0003254)2.74958739
28Abnormality of T cell number (HP:0011839)2.72250875
29Abnormality of renal resorption (HP:0011038)2.69875728
30Pancytopenia (HP:0001876)2.62608601
31Abnormality of the prostate (HP:0008775)2.60889797
32Lissencephaly (HP:0001339)2.58904651
33Akinesia (HP:0002304)2.58466652
34Cerebellar dysplasia (HP:0007033)2.57001023
35Increased hepatocellular lipid droplets (HP:0006565)2.55290223
36Aplasia of the musculature (HP:0100854)2.52696789
37Pustule (HP:0200039)2.47641168
38Oligodactyly (hands) (HP:0001180)2.30531825
39Protruding tongue (HP:0010808)2.27583157
40Lipid accumulation in hepatocytes (HP:0006561)2.25376757
41Capillary hemangiomas (HP:0005306)2.25064450
42Abnormality of male internal genitalia (HP:0000022)2.21275337
43Degeneration of anterior horn cells (HP:0002398)2.19350578
44Abnormality of the anterior horn cell (HP:0006802)2.19350578
45Metaphyseal dysplasia (HP:0100255)2.18701554
46Recurrent fungal infections (HP:0002841)2.18661653
47Alveolar cell carcinoma (HP:0006519)2.18102699
48Hypoplastic nipples (HP:0002557)2.11784873
49Exertional dyspnea (HP:0002875)2.11057204
50Chronic hepatic failure (HP:0100626)2.09799152
51Rib fusion (HP:0000902)2.03178250
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.02587905
53Abnormality of T cells (HP:0002843)2.01135926
54Abnormality of eosinophils (HP:0001879)1.99469269
55Slow saccadic eye movements (HP:0000514)1.97254759
56Pheochromocytoma (HP:0002666)1.97109568
57Panhypogammaglobulinemia (HP:0003139)1.97044536
58Constricted visual fields (HP:0001133)1.96606233
59Hyperphosphaturia (HP:0003109)1.95007999
60Hyperglycinuria (HP:0003108)1.93118798
61Amyloidosis (HP:0011034)1.92642560
62Pancreatic cysts (HP:0001737)1.92495873
63Rough bone trabeculation (HP:0100670)1.91595240
64Deep philtrum (HP:0002002)1.89577922
65Premature graying of hair (HP:0002216)1.88771715
66Opisthotonus (HP:0002179)1.86666160
67Gingivitis (HP:0000230)1.86282058
68Abnormality of glycine metabolism (HP:0010895)1.85942170
69Abnormality of serine family amino acid metabolism (HP:0010894)1.85942170
70Hemiplegia (HP:0002301)1.85664725
71Attenuation of retinal blood vessels (HP:0007843)1.85581641
72Cutaneous melanoma (HP:0012056)1.85184456
73Reduced antithrombin III activity (HP:0001976)1.83169059
74Neoplasm of the tracheobronchial system (HP:0100552)1.82920199
75Abnormality of calcium-phosphate metabolism (HP:0100530)1.82060196
76Aplasia/hypoplasia of the uterus (HP:0008684)1.81454990
77Molar tooth sign on MRI (HP:0002419)1.81450951
78Abnormality of midbrain morphology (HP:0002418)1.81450951
79Self-mutilation (HP:0000742)1.81064159
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80158929
81Abnormal albumin level (HP:0012116)1.78795401
82Hypoalbuminemia (HP:0003073)1.78795401
83Hyperlipoproteinemia (HP:0010980)1.77093193
84Abnormal mitochondria in muscle tissue (HP:0008316)1.75116364
85Megalocornea (HP:0000485)1.72667651
86Eczematoid dermatitis (HP:0000976)1.72516788
87Abnormality of the periventricular white matter (HP:0002518)1.72317264
88Increased CSF lactate (HP:0002490)1.71220168
89Chronic diarrhea (HP:0002028)1.71095250
90Increased intramyocellular lipid droplets (HP:0012240)1.70023862
91Urinary bladder sphincter dysfunction (HP:0002839)1.68915609
92Spinal muscular atrophy (HP:0007269)1.68267312
93Keratitis (HP:0000491)1.67953805
94Recurrent bacterial skin infections (HP:0005406)1.67679937
95Poor suck (HP:0002033)1.67615601
96Abnormality of placental membranes (HP:0011409)1.64672872
97Amniotic constriction ring (HP:0009775)1.64672872
98Abnormality of the columella (HP:0009929)1.64600439
99Recurrent bronchitis (HP:0002837)1.64556971
100Polyneuropathy (HP:0001271)1.64182293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.63702399
2SCYL22.90203013
3ZAK2.63551950
4NUAK12.45673898
5PIM22.43060289
6MAP3K122.11541138
7MAP4K12.01677919
8TLK11.97632375
9DYRK21.95665595
10LATS11.94542750
11IKBKE1.94378618
12TRPM71.92611639
13BMPR21.90113583
14TAOK11.88056707
15INSRR1.86533179
16CAMKK21.84035667
17PIM11.79233453
18TAOK21.68609736
19MAP3K111.67054299
20ZAP701.62202101
21IKBKB1.62119832
22ITK1.54584188
23GRK61.50051343
24FRK1.48155420
25PIK3CA1.47930603
26NTRK11.43331302
27CSNK1A1L1.34779835
28CHUK1.33699517
29HIPK21.28481063
30AKT31.28407912
31TIE11.28184977
32RIPK41.28170011
33PIK3CG1.27210349
34MAP3K141.27052155
35MARK31.25507265
36TXK1.20561756
37CSNK1G21.18558268
38MAP2K31.17140210
39FES1.16072179
40MAP3K71.12632089
41SYK1.11922019
42MAPKAPK51.08794513
43MATK1.08438024
44BTK1.05046196
45MAP3K31.03871728
46RPS6KA51.01546635
47ADRBK20.99905687
48CSNK1G30.99573191
49MST40.99462585
50ERBB30.98547312
51GRK50.98398162
52VRK10.94598039
53CDK80.94592109
54BLK0.92158488
55DAPK20.92109319
56EIF2AK20.91675611
57TEC0.89814639
58TAF10.83120254
59LCK0.82957598
60KIT0.79193296
61STK160.78859669
62CSNK1G10.77852344
63CAMK1D0.76054686
64NEK60.74654400
65CAMKK10.74623997
66PHKG10.73438587
67PHKG20.73438587
68EIF2AK30.73436573
69MAP2K20.72987581
70KDR0.72503248
71JAK30.72453307
72PAK30.71612833
73CHEK20.71549177
74GRK10.68671517
75CDK40.68527323
76PAK60.66849364
77DAPK30.66283443
78LYN0.63329315
79ABL10.62618023
80GRK70.58948849
81HCK0.57939044
82PRKCI0.57676138
83STK100.57503990
84TBK10.53578612
85STK390.53030808
86CSF1R0.51570035
87PRKAA10.50218957
88ERBB20.47904585
89OXSR10.46530994
90IRAK40.45404324
91PKN10.40732434
92PRKCQ0.38574941
93DAPK10.37989507
94PRKD20.37524855
95NME10.34856633
96MKNK10.34327563
97CDK90.33269235
98IGF1R0.32261042
99JAK10.31071728
100ADRBK10.29634110

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.14307735
2Primary immunodeficiency_Homo sapiens_hsa053404.02551249
3Allograft rejection_Homo sapiens_hsa053303.81281185
4Autoimmune thyroid disease_Homo sapiens_hsa053203.54712858
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.31892371
6Graft-versus-host disease_Homo sapiens_hsa053323.10191823
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07351498
8Systemic lupus erythematosus_Homo sapiens_hsa053223.02216722
9Type I diabetes mellitus_Homo sapiens_hsa049402.83053422
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54457040
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41020968
12Linoleic acid metabolism_Homo sapiens_hsa005912.37874257
13Antigen processing and presentation_Homo sapiens_hsa046122.29643286
14Viral myocarditis_Homo sapiens_hsa054162.16502628
15Ether lipid metabolism_Homo sapiens_hsa005652.09292956
16T cell receptor signaling pathway_Homo sapiens_hsa046601.98456254
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.77115472
18Leishmaniasis_Homo sapiens_hsa051401.63711580
19Staphylococcus aureus infection_Homo sapiens_hsa051501.47437108
20Alcoholism_Homo sapiens_hsa050341.45747250
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43684149
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.43350122
23Regulation of autophagy_Homo sapiens_hsa041401.34339826
24Rheumatoid arthritis_Homo sapiens_hsa053231.30455646
25Selenocompound metabolism_Homo sapiens_hsa004501.28895429
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24586426
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21333474
28Nitrogen metabolism_Homo sapiens_hsa009101.16293468
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15226867
30Proteasome_Homo sapiens_hsa030501.10429700
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09719613
32Phototransduction_Homo sapiens_hsa047441.05910675
33Toxoplasmosis_Homo sapiens_hsa051451.04060223
34Hematopoietic cell lineage_Homo sapiens_hsa046401.00183020
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99611672
36Nicotine addiction_Homo sapiens_hsa050330.94251581
37p53 signaling pathway_Homo sapiens_hsa041150.89590765
38Oxidative phosphorylation_Homo sapiens_hsa001900.88263921
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.85658697
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84926505
41Arachidonic acid metabolism_Homo sapiens_hsa005900.83958260
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83829486
43Circadian rhythm_Homo sapiens_hsa047100.80896446
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79615518
45Salivary secretion_Homo sapiens_hsa049700.73559104
46Measles_Homo sapiens_hsa051620.73376782
47Olfactory transduction_Homo sapiens_hsa047400.72586387
48Circadian entrainment_Homo sapiens_hsa047130.68168961
49Tryptophan metabolism_Homo sapiens_hsa003800.65735690
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65306992
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61380264
52Folate biosynthesis_Homo sapiens_hsa007900.59166460
53Herpes simplex infection_Homo sapiens_hsa051680.57119769
54Legionellosis_Homo sapiens_hsa051340.55862802
55Peroxisome_Homo sapiens_hsa041460.55469743
56Spliceosome_Homo sapiens_hsa030400.55436650
57Tuberculosis_Homo sapiens_hsa051520.55240406
58Morphine addiction_Homo sapiens_hsa050320.54983124
59Serotonergic synapse_Homo sapiens_hsa047260.54137901
60Cardiac muscle contraction_Homo sapiens_hsa042600.53963369
61Inositol phosphate metabolism_Homo sapiens_hsa005620.52826220
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52403635
63Gastric acid secretion_Homo sapiens_hsa049710.51500146
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51302109
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50028316
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47972192
67Collecting duct acid secretion_Homo sapiens_hsa049660.47142942
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46771158
69GABAergic synapse_Homo sapiens_hsa047270.45660681
70Viral carcinogenesis_Homo sapiens_hsa052030.45320655
71Taste transduction_Homo sapiens_hsa047420.44914832
72Oxytocin signaling pathway_Homo sapiens_hsa049210.44405698
73Chemical carcinogenesis_Homo sapiens_hsa052040.43908534
74B cell receptor signaling pathway_Homo sapiens_hsa046620.43357126
75Epstein-Barr virus infection_Homo sapiens_hsa051690.43269539
76Parkinsons disease_Homo sapiens_hsa050120.42350310
77Influenza A_Homo sapiens_hsa051640.42118604
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41753810
79Homologous recombination_Homo sapiens_hsa034400.40365588
80Glutathione metabolism_Homo sapiens_hsa004800.38529218
81Shigellosis_Homo sapiens_hsa051310.38049815
82Synaptic vesicle cycle_Homo sapiens_hsa047210.38035891
83Calcium signaling pathway_Homo sapiens_hsa040200.37481495
84ABC transporters_Homo sapiens_hsa020100.36446867
85Ovarian steroidogenesis_Homo sapiens_hsa049130.36400721
86Vitamin digestion and absorption_Homo sapiens_hsa049770.35712983
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35591324
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.34135153
89Apoptosis_Homo sapiens_hsa042100.34095903
90Nucleotide excision repair_Homo sapiens_hsa034200.33999839
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32368540
92Alzheimers disease_Homo sapiens_hsa050100.29151657
93Cholinergic synapse_Homo sapiens_hsa047250.28410897
94Phagosome_Homo sapiens_hsa041450.26212578
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25788650
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22448152
97Caffeine metabolism_Homo sapiens_hsa002320.22056126
98RNA polymerase_Homo sapiens_hsa030200.20273641
99Pyrimidine metabolism_Homo sapiens_hsa002400.19084945
100TNF signaling pathway_Homo sapiens_hsa046680.19025589

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