ARF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.45068944
2locomotory exploration behavior (GO:0035641)6.30481917
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18677090
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.95487565
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51496008
6synaptic vesicle exocytosis (GO:0016079)5.46163574
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.45603729
8vocalization behavior (GO:0071625)5.42886396
9glutamate secretion (GO:0014047)5.31559375
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27522184
11regulation of glutamate receptor signaling pathway (GO:1900449)5.08733989
12regulation of synaptic vesicle exocytosis (GO:2000300)5.06267179
13cytoskeletal anchoring at plasma membrane (GO:0007016)4.97345414
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.82586835
15regulation of neuronal synaptic plasticity (GO:0048168)4.77743050
16regulation of synapse structural plasticity (GO:0051823)4.74935763
17exploration behavior (GO:0035640)4.74043492
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.60131224
19regulation of synaptic vesicle transport (GO:1902803)4.52596341
20protein localization to synapse (GO:0035418)4.46265881
21neurotransmitter secretion (GO:0007269)4.34300574
22layer formation in cerebral cortex (GO:0021819)4.34219645
23dendritic spine morphogenesis (GO:0060997)4.33046695
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07089764
25amino acid import (GO:0043090)4.04659340
26synaptic transmission, glutamatergic (GO:0035249)4.03771684
27protein localization to endosome (GO:0036010)4.02586370
28neuronal action potential propagation (GO:0019227)4.00981559
29long-term memory (GO:0007616)4.00286880
30cerebellar granule cell differentiation (GO:0021707)3.95671457
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93255460
32glutamate receptor signaling pathway (GO:0007215)3.91013848
33neurotransmitter-gated ion channel clustering (GO:0072578)3.91009327
34positive regulation of membrane potential (GO:0045838)3.90237891
35L-amino acid import (GO:0043092)3.90089885
36regulation of dendritic spine morphogenesis (GO:0061001)3.88903157
37proline transport (GO:0015824)3.87295204
38regulation of synaptic plasticity (GO:0048167)3.85919874
39neuron cell-cell adhesion (GO:0007158)3.83104971
40cellular potassium ion homeostasis (GO:0030007)3.83032084
41neuron-neuron synaptic transmission (GO:0007270)3.82927075
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75038982
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.74957285
44regulation of early endosome to late endosome transport (GO:2000641)3.74526066
45neuromuscular process controlling balance (GO:0050885)3.73751264
46COPI coating of Golgi vesicle (GO:0048205)3.73037302
47Golgi transport vesicle coating (GO:0048200)3.73037302
48activation of protein kinase A activity (GO:0034199)3.69554757
49regulation of postsynaptic membrane potential (GO:0060078)3.69221122
50sodium ion export (GO:0071436)3.62973405
51negative regulation of microtubule polymerization (GO:0031115)3.55961800
52prepulse inhibition (GO:0060134)3.55031636
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.53851511
54positive regulation of neurotransmitter transport (GO:0051590)3.53581766
55long-term synaptic potentiation (GO:0060291)3.51638412
56positive regulation of neurotransmitter secretion (GO:0001956)3.50749731
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49672375
58gamma-aminobutyric acid transport (GO:0015812)3.46900202
59activation of Rac GTPase activity (GO:0032863)3.45722348
60protein retention in ER lumen (GO:0006621)3.45371383
61auditory behavior (GO:0031223)3.44098527
62synaptic vesicle endocytosis (GO:0048488)3.43569874
63chemosensory behavior (GO:0007635)3.43345772
64positive regulation of synapse maturation (GO:0090129)3.42194484
65dendritic spine organization (GO:0097061)3.40184306
66neurotransmitter transport (GO:0006836)3.39387274
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38137627
68adherens junction assembly (GO:0034333)3.36618041
69mating behavior (GO:0007617)3.30776454
70regulation of neurotransmitter secretion (GO:0046928)3.30533487
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.30402151
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29713270
73vesicle transport along microtubule (GO:0047496)3.27671482
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26251495
75response to auditory stimulus (GO:0010996)3.25314864
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25030295
77regulation of ARF protein signal transduction (GO:0032012)3.24864950
78regulation of neurotransmitter levels (GO:0001505)3.22385388
79regulation of dendritic spine development (GO:0060998)3.22063305
80regulation of vesicle fusion (GO:0031338)3.21780167
81behavioral defense response (GO:0002209)3.19833676
82behavioral fear response (GO:0001662)3.19833676
83stress fiber assembly (GO:0043149)3.19481454
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17927333
85response to histamine (GO:0034776)3.16047642
86transmission of nerve impulse (GO:0019226)3.14053623
87glycine transport (GO:0015816)3.12738101
88focal adhesion assembly (GO:0048041)3.12533520
89cell-substrate adherens junction assembly (GO:0007045)3.12533520
90regulation of neurotransmitter transport (GO:0051588)3.12505367
91neuronal ion channel clustering (GO:0045161)3.12205226
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11915482
93negative regulation of dendrite morphogenesis (GO:0050774)3.10766490
94neuron recognition (GO:0008038)3.10655036
95positive regulation of synaptic transmission (GO:0050806)3.07367342
96innervation (GO:0060384)3.06694233
97learning (GO:0007612)3.06116826
98regulation of clathrin-mediated endocytosis (GO:2000369)3.05989090
99negative regulation of erythrocyte differentiation (GO:0045647)3.05671105
100membrane depolarization (GO:0051899)3.05161267
101positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.02926901
102dendrite morphogenesis (GO:0048813)3.02680086
103positive regulation of dendritic spine development (GO:0060999)3.02495934
104cell communication by electrical coupling (GO:0010644)3.02113641
105regulation of female receptivity (GO:0045924)3.00867785
106cerebellar Purkinje cell differentiation (GO:0021702)2.99938664
107neuromuscular process (GO:0050905)2.99252701
108regulation of synaptic transmission (GO:0050804)2.98520025
109peptidyl-tyrosine autophosphorylation (GO:0038083)2.98111929
110neuromuscular process controlling posture (GO:0050884)2.98005119
111positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.96694610
112regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.96694610
113membrane hyperpolarization (GO:0060081)2.95727287
114long term synaptic depression (GO:0060292)2.93784701
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.93642773
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93427673
117fear response (GO:0042596)2.93402313
118dopamine receptor signaling pathway (GO:0007212)2.92687939
119social behavior (GO:0035176)2.91215457
120intraspecies interaction between organisms (GO:0051703)2.91215457
121axonal fasciculation (GO:0007413)2.91172354
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.90587429
123adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87949028
124behavioral response to cocaine (GO:0048148)2.86819195
125maternal placenta development (GO:0001893)2.86144466
126potassium ion homeostasis (GO:0055075)2.85898143
127positive regulation of protein dephosphorylation (GO:0035307)2.82430950
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81461753
129cerebellar Purkinje cell layer development (GO:0021680)2.76968972
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.74751798
131regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.71873417
132response to parathyroid hormone (GO:0071107)2.71062424
133semaphorin-plexin signaling pathway (GO:0071526)2.70570248
134signal complex assembly (GO:0007172)2.69683167
135protein complex localization (GO:0031503)2.68710546
136protein targeting to plasma membrane (GO:0072661)2.67798667
137epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65583616
138positive regulation of nitric-oxide synthase activity (GO:0051000)2.65124594
139cellular protein complex localization (GO:0034629)2.62147362
140barbed-end actin filament capping (GO:0051016)2.61500966
141actin filament bundle organization (GO:0061572)2.57671867
142actin filament bundle assembly (GO:0051017)2.57671867
143cell-substrate junction assembly (GO:0007044)2.56610831
144cell-cell junction maintenance (GO:0045217)2.56568261
145cortical actin cytoskeleton organization (GO:0030866)2.54961798
146regulation of protein dephosphorylation (GO:0035304)2.46482228
147regulation of NFAT protein import into nucleus (GO:0051532)2.44522103
148myelin maintenance (GO:0043217)2.43583695
149regulation of glucose import in response to insulin stimulus (GO:2001273)2.41724787
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41220243
151regulation of defense response to virus by virus (GO:0050690)2.38916161
152epithelial cell-cell adhesion (GO:0090136)2.37990435
153positive regulation of receptor recycling (GO:0001921)2.36229410
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.34185660
155cellular sodium ion homeostasis (GO:0006883)2.31294070
156positive regulation of Rap GTPase activity (GO:0032854)2.31226316
157desmosome organization (GO:0002934)2.31074772
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26933305
159regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.26460681
160cell communication involved in cardiac conduction (GO:0086065)2.25231572
161regulation of synapse maturation (GO:0090128)2.24513020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83161679
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.13079140
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.09511409
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00597543
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97167535
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93840087
7GBX2_23144817_ChIP-Seq_PC3_Human2.90603496
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80312684
9DROSHA_22980978_ChIP-Seq_HELA_Human2.69619617
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69617321
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69617321
12REST_21632747_ChIP-Seq_MESCs_Mouse2.67438309
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.66409700
14LXR_22292898_ChIP-Seq_THP-1_Human2.59132727
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57188300
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53716459
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50926126
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49554452
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36274801
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35751234
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34980921
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.33679654
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32044991
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.27833505
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27629674
26RACK7_27058665_Chip-Seq_MCF-7_Human2.24599786
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21687082
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.19584781
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.17931247
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.13264177
31MYC_22102868_ChIP-Seq_BL_Human2.00841398
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.00171732
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96120818
34TCF7_22412390_ChIP-Seq_EML_Mouse1.95561998
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95460397
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95296777
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93265265
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89514793
39KDM2B_26808549_Chip-Seq_DND41_Human1.89425512
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88774250
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.87803487
42ZNF263_19887448_ChIP-Seq_K562_Human1.86821710
43AR_21572438_ChIP-Seq_LNCaP_Human1.83239222
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.81732952
45CLOCK_20551151_ChIP-Seq_293T_Human1.80402310
46VDR_21846776_ChIP-Seq_THP-1_Human1.77557623
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73948921
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72843722
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.70811241
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70494636
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55303202
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51139839
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50250373
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49485233
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49482201
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45361906
57SMAD4_21799915_ChIP-Seq_A2780_Human1.44922352
58* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44106116
59KDM2B_26808549_Chip-Seq_K562_Human1.43718253
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41244839
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40884891
62SMC4_20622854_ChIP-Seq_HELA_Human1.40783528
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39811426
64* CREB1_26743006_Chip-Seq_LNCaP_Human1.39790241
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39009653
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38117323
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38039954
68* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37203576
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37188112
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36118969
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35955137
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33177091
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.33071321
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32484808
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.31486400
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30855780
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.28837784
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28767024
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28674922
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28341378
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27698622
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.26232611
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25985355
84* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25895642
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25365862
86AR_19668381_ChIP-Seq_PC3_Human1.24807301
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.24721765
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23859154
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23655830
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22296830
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22111595
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22095045
93P68_20966046_ChIP-Seq_HELA_Human1.21872411
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21068427
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.19934236
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19788699
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18036921
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.17927484
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17410844
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17161887
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.16305762
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15808119
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15093088
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15022202
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14843485
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14141708
107TRIM28_21343339_ChIP-Seq_HEK293_Human1.13628621
108ZNF274_21170338_ChIP-Seq_K562_Hela1.13551764
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.12779170
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12258094
111STAT3_23295773_ChIP-Seq_U87_Human1.11661970
112RXR_22108803_ChIP-Seq_LS180_Human1.10423840
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09737712
114AR_25329375_ChIP-Seq_VCAP_Human1.08267053
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08217488
116* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07477222
117* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06861876
118* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06581088
119TAF15_26573619_Chip-Seq_HEK293_Human1.05620180
120TP53_16413492_ChIP-PET_HCT116_Human1.05608162
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05525857
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04044659
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.03019272
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.02000111
125AHR_22903824_ChIP-Seq_MCF-7_Human1.01954028
126ATF3_27146783_Chip-Seq_COLON_Human1.01869319
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01633874
128VDR_24763502_ChIP-Seq_THP-1_Human1.00976570
129P300_19829295_ChIP-Seq_ESCs_Human1.00974956
130SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00245891
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00205085
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99988498
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99671073
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98573561
135* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98332553
136* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96542755
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.96466894
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.95923858
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95707022
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.94997159
141* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94029496
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93949286
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93852943
144* TCF4_23295773_ChIP-Seq_U87_Human0.93497810
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93191857
146KAP1_27257070_Chip-Seq_ESCs_Mouse0.92423380
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92077016
148CTCF_27219007_Chip-Seq_Bcells_Human0.91010837
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90728365
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89908222
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89543221
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89061579
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89024882
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88904041
155RUNX1_22412390_ChIP-Seq_EML_Mouse0.87951870
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87661799
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87400820
158JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87269120
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86309613
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86223468
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.84547546
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.84201504
163AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83767207
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83674535
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82372277
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.82358564
167TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81843056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.73870555
2MP0003880_abnormal_central_pattern4.58749831
3MP0003635_abnormal_synaptic_transmissio4.45024308
4MP0003705_abnormal_hypodermis_morpholog4.25012985
5MP0002822_catalepsy3.99634342
6MP0004270_analgesia3.96002031
7MP0002063_abnormal_learning/memory/cond3.60666826
8MP0009745_abnormal_behavioral_response3.55191252
9MP0002064_seizures3.22215071
10MP0002572_abnormal_emotion/affect_behav2.90751511
11MP0001968_abnormal_touch/_nociception2.83515604
12MP0009046_muscle_twitch2.79440225
13MP0001486_abnormal_startle_reflex2.58222130
14MP0005423_abnormal_somatic_nervous2.51205844
15MP0002734_abnormal_mechanical_nocicepti2.44309355
16MP0002272_abnormal_nervous_system2.42563869
17MP0003566_abnormal_cell_adhesion2.38893802
18MP0002796_impaired_skin_barrier2.32058627
19MP0001501_abnormal_sleep_pattern2.30108249
20MP0002877_abnormal_melanocyte_morpholog2.27493061
21MP0009780_abnormal_chondrocyte_physiolo2.26635574
22MP0005058_abnormal_lysosome_morphology2.18460682
23MP0002909_abnormal_adrenal_gland2.13589953
24MP0001849_ear_inflammation2.12992203
25MP0004858_abnormal_nervous_system2.01492072
26MP0005076_abnormal_cell_differentiation2.01460978
27MP0002736_abnormal_nociception_after1.99963441
28MP0001440_abnormal_grooming_behavior1.98198298
29MP0004811_abnormal_neuron_physiology1.93675356
30MP0002733_abnormal_thermal_nociception1.90435573
31MP0001970_abnormal_pain_threshold1.87533722
32MP0008569_lethality_at_weaning1.84263592
33MP0000579_abnormal_nail_morphology1.83020699
34MP0002735_abnormal_chemical_nociception1.82899113
35MP0000537_abnormal_urethra_morphology1.80810345
36MP0003329_amyloid_beta_deposits1.79173777
37MP0003879_abnormal_hair_cell1.75088576
38MP0002557_abnormal_social/conspecific_i1.71600554
39MP0004185_abnormal_adipocyte_glucose1.70564853
40MP0005386_behavior/neurological_phenoty1.68983679
41MP0004924_abnormal_behavior1.68983679
42MP0005646_abnormal_pituitary_gland1.68632761
43MP0002067_abnormal_sensory_capabilities1.65626517
44MP0001348_abnormal_lacrimal_gland1.64024653
45MP0003453_abnormal_keratinocyte_physiol1.61712571
46MP0003123_paternal_imprinting1.60903241
47MP0008260_abnormal_autophagy1.55632751
48MP0004264_abnormal_extraembryonic_tissu1.54475649
49MP0002184_abnormal_innervation1.54388330
50MP0003191_abnormal_cellular_cholesterol1.52318164
51MP0000569_abnormal_digit_pigmentation1.51416862
52MP0000778_abnormal_nervous_system1.49925900
53MP0003787_abnormal_imprinting1.49740172
54MP0003091_abnormal_cell_migration1.46882032
55MP0004885_abnormal_endolymph1.45341085
56MP0003633_abnormal_nervous_system1.43897890
57MP0000955_abnormal_spinal_cord1.41768367
58MP0009672_abnormal_birth_weight1.40049068
59MP0001984_abnormal_olfaction1.39381263
60MP0002089_abnormal_postnatal_growth/wei1.38916419
61MP0005451_abnormal_body_composition1.37752572
62MP0003075_altered_response_to1.36306151
63MP0002066_abnormal_motor_capabilities/c1.36090506
64MP0001346_abnormal_lacrimal_gland1.34941148
65MP0008961_abnormal_basal_metabolism1.33013361
66MP0003300_gastrointestinal_ulcer1.32907990
67MP0005501_abnormal_skin_physiology1.31991444
68MP0002882_abnormal_neuron_morphology1.29952641
69MP0010352_gastrointestinal_tract_polyps1.28392781
70MP0001529_abnormal_vocalization1.27927491
71MP0000566_synostosis1.27795694
72MP0010234_abnormal_vibrissa_follicle1.23506495
73MP0005645_abnormal_hypothalamus_physiol1.16925122
74MP0008874_decreased_physiological_sensi1.14254430
75MP0003631_nervous_system_phenotype1.14089306
76MP0000678_abnormal_parathyroid_gland1.12992916
77MP0001502_abnormal_circadian_rhythm1.10134392
78MP0001905_abnormal_dopamine_level1.07225557
79MP0006276_abnormal_autonomic_nervous1.06776965
80MP0008872_abnormal_physiological_respon1.06680068
81MP0003183_abnormal_peptide_metabolism1.06184648
82MP0002152_abnormal_brain_morphology1.05870953
83MP0004947_skin_inflammation1.04597556
84MP0003122_maternal_imprinting1.04296168
85MP0004782_abnormal_surfactant_physiolog1.00741717
86MP0003283_abnormal_digestive_organ0.98793548
87MP0002069_abnormal_eating/drinking_beha0.98186277
88MP0005167_abnormal_blood-brain_barrier0.97488567
89MP0001177_atelectasis0.97465010
90MP0005666_abnormal_adipose_tissue0.94177322
91MP0004510_myositis0.90228095
92MP0002098_abnormal_vibrissa_morphology0.90029721
93MP0005621_abnormal_cell_physiology0.89822672
94MP0000013_abnormal_adipose_tissue0.88865280
95MP0000462_abnormal_digestive_system0.88836014
96MP0009278_abnormal_bone_marrow0.88581896
97MP0002896_abnormal_bone_mineralization0.87024258
98MP0003172_abnormal_lysosome_physiology0.86174517
99MP0003690_abnormal_glial_cell0.83882436
100MP0000604_amyloidosis0.83251118
101MP0005409_darkened_coat_color0.83212324
102MP0004085_abnormal_heartbeat0.81900649
103MP0001188_hyperpigmentation0.81827597
104MP0005535_abnormal_body_temperature0.81493733
105MP0005257_abnormal_intraocular_pressure0.81235590
106MP0001730_embryonic_growth_arrest0.80408752
107MP0002090_abnormal_vision0.78759660
108MP0000467_abnormal_esophagus_morphology0.77433850
109MP0000627_abnormal_mammary_gland0.77338668
110MP0002249_abnormal_larynx_morphology0.75150708
111MP0002229_neurodegeneration0.74347997
112MP0003634_abnormal_glial_cell0.74192225
113MP0000751_myopathy0.73882100
114MP0004142_abnormal_muscle_tone0.73515305
115MP0010678_abnormal_skin_adnexa0.70457645
116MP0002060_abnormal_skin_morphology0.70305361
117MP0000858_altered_metastatic_potential0.69774439
118MP0005623_abnormal_meninges_morphology0.69495198
119MP0005394_taste/olfaction_phenotype0.69477422
120MP0005499_abnormal_olfactory_system0.69477422
121MP0000377_abnormal_hair_follicle0.69257667
122MP0000920_abnormal_myelination0.68975000
123MP0010771_integument_phenotype0.68963546
124MP0009840_abnormal_foam_cell0.68909666
125MP0003632_abnormal_nervous_system0.67972617
126MP0001958_emphysema0.67011538
127MP0001216_abnormal_epidermal_layer0.66190752
128MP0008438_abnormal_cutaneous_collagen0.65620987
129MP0000681_abnormal_thyroid_gland0.64528081
130MP0010386_abnormal_urinary_bladder0.64266143
131MP0005375_adipose_tissue_phenotype0.63772686
132MP0004233_abnormal_muscle_weight0.63687596
133MP0005166_decreased_susceptibility_to0.61811649
134MP0004484_altered_response_of0.61681847
135MP0000534_abnormal_ureter_morphology0.61615518
136MP0004742_abnormal_vestibular_system0.60963331
137MP0000631_abnormal_neuroendocrine_gland0.60730989
138MP0001664_abnormal_digestion0.60585074
139MP0001963_abnormal_hearing_physiology0.59935378
140MP0003045_fibrosis0.58129601
141MP0003303_peritoneal_inflammation0.56252143
142MP0001299_abnormal_eye_distance/0.55224944
143MP0005187_abnormal_penis_morphology0.53193667
144MP0001943_abnormal_respiration0.50504063
145MP0010769_abnormal_survival0.50230546
146MP0003861_abnormal_nervous_system0.48885855
147MP0004145_abnormal_muscle_electrophysio0.48313245
148MP0001485_abnormal_pinna_reflex0.47979051
149MP0003956_abnormal_body_size0.47836659
150MP0004130_abnormal_muscle_cell0.47786610
151MP0005551_abnormal_eye_electrophysiolog0.47277901
152MP0002752_abnormal_somatic_nervous0.46904236

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.62578747
2Focal motor seizures (HP:0011153)7.53348727
3Focal seizures (HP:0007359)5.79766595
4Visual hallucinations (HP:0002367)5.17981647
5Epileptic encephalopathy (HP:0200134)4.47778643
6Action tremor (HP:0002345)4.05454844
7Atonic seizures (HP:0010819)3.88481496
8Progressive cerebellar ataxia (HP:0002073)3.87806587
9Absence seizures (HP:0002121)3.86852775
10Febrile seizures (HP:0002373)3.80485799
11Papilledema (HP:0001085)3.79481867
12Generalized tonic-clonic seizures (HP:0002069)3.73491318
13Impaired vibration sensation in the lower limbs (HP:0002166)3.55355551
14Poor eye contact (HP:0000817)3.54182393
15Supranuclear gaze palsy (HP:0000605)3.53485511
16Dialeptic seizures (HP:0011146)3.53079632
17Hyperacusis (HP:0010780)3.45962785
18Ankle clonus (HP:0011448)3.45757770
19Depression (HP:0000716)3.43233967
20Broad-based gait (HP:0002136)3.31011180
21Urinary bladder sphincter dysfunction (HP:0002839)3.27985535
22Impaired social interactions (HP:0000735)3.25661014
23Abnormal social behavior (HP:0012433)3.25661014
24Postural instability (HP:0002172)3.15583291
25Anxiety (HP:0000739)3.11274148
26Torticollis (HP:0000473)3.10798687
27Gaze-evoked nystagmus (HP:0000640)3.07444333
28Dysmetria (HP:0001310)3.02538792
29Dysdiadochokinesis (HP:0002075)3.01638176
30Mutism (HP:0002300)3.00479537
31Annular pancreas (HP:0001734)2.98209268
32Amblyopia (HP:0000646)2.91473956
33Abnormality of the lower motor neuron (HP:0002366)2.87584763
34Genetic anticipation (HP:0003743)2.87475661
35Focal dystonia (HP:0004373)2.87038948
36Truncal ataxia (HP:0002078)2.86078700
37Stereotypic behavior (HP:0000733)2.82808156
38Urinary urgency (HP:0000012)2.80409243
39Abnormal eating behavior (HP:0100738)2.75597612
40Impaired smooth pursuit (HP:0007772)2.73845185
41Hyperventilation (HP:0002883)2.72506225
42Cerebral inclusion bodies (HP:0100314)2.60037874
43Pointed chin (HP:0000307)2.59037566
44Ankyloglossia (HP:0010296)2.57004981
45Hyperparathyroidism (HP:0000843)2.55987172
46Dysmetric saccades (HP:0000641)2.54671994
47Craniofacial dystonia (HP:0012179)2.53270181
48Megalencephaly (HP:0001355)2.50947808
49Excessive salivation (HP:0003781)2.50384218
50Drooling (HP:0002307)2.50384218
51Bradykinesia (HP:0002067)2.48360165
52Obstructive sleep apnea (HP:0002870)2.40862632
53Intention tremor (HP:0002080)2.40815902
54Hemiplegia (HP:0002301)2.39573182
55Spastic gait (HP:0002064)2.39455637
56Neurofibrillary tangles (HP:0002185)2.39159151
57Upper limb amyotrophy (HP:0009129)2.38648167
58Distal upper limb amyotrophy (HP:0007149)2.38648167
59Abnormality of ocular smooth pursuit (HP:0000617)2.38149812
60Insidious onset (HP:0003587)2.37587944
61Termporal pattern (HP:0011008)2.37587944
62Impaired vibratory sensation (HP:0002495)2.34556875
63Ventricular fibrillation (HP:0001663)2.33600305
64Resting tremor (HP:0002322)2.30446518
65Epileptiform EEG discharges (HP:0011182)2.28547829
66Diplopia (HP:0000651)2.27425747
67Abnormality of binocular vision (HP:0011514)2.27425747
68Spinal cord compression (HP:0002176)2.25623041
69Broad face (HP:0000283)2.24324781
70Overriding aorta (HP:0002623)2.24272452
71Scanning speech (HP:0002168)2.24035932
72Distal lower limb amyotrophy (HP:0008944)2.23717278
73Lower limb amyotrophy (HP:0007210)2.23537862
74Status epilepticus (HP:0002133)2.19001281
75EEG with generalized epileptiform discharges (HP:0011198)2.17799805
76Absent speech (HP:0001344)2.15539475
77Insomnia (HP:0100785)2.14058029
78Hemiparesis (HP:0001269)2.13818959
79Progressive inability to walk (HP:0002505)2.12231309
80Hypsarrhythmia (HP:0002521)2.10260875
81Shallow orbits (HP:0000586)2.09791317
82Peripheral hypomyelination (HP:0007182)2.06178411
83Asymmetry of the thorax (HP:0001555)2.06149961
84Inappropriate behavior (HP:0000719)2.03890751
85Cerebral aneurysm (HP:0004944)2.03317217
86Generalized myoclonic seizures (HP:0002123)2.03294412
87Bronchomalacia (HP:0002780)2.01673302
88Protrusio acetabuli (HP:0003179)2.01204275
89Lower limb muscle weakness (HP:0007340)2.00804235
90Limb dystonia (HP:0002451)2.00787635
91Bundle branch block (HP:0011710)2.00094112
92Hand muscle atrophy (HP:0009130)1.99757435
93Distal lower limb muscle weakness (HP:0009053)1.99329682
94Aplasia involving bones of the upper limbs (HP:0009823)1.98552049
95Aplasia of the phalanges of the hand (HP:0009802)1.98552049
96Aplasia involving bones of the extremities (HP:0009825)1.98552049
97Apathy (HP:0000741)1.98251719
98Flat acetabular roof (HP:0003180)1.97533679
99Incomplete penetrance (HP:0003829)1.96742108
100Rapidly progressive (HP:0003678)1.96596605
101Neuronal loss in central nervous system (HP:0002529)1.95915024
102Long palpebral fissure (HP:0000637)1.95849277
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95817203
104Tetraplegia (HP:0002445)1.93370793
105Lower limb asymmetry (HP:0100559)1.93318912
106Abnormality of oral frenula (HP:0000190)1.92423107
107Fetal akinesia sequence (HP:0001989)1.92141631
108Arnold-Chiari malformation (HP:0002308)1.90749704
109Turricephaly (HP:0000262)1.87664278
110Akinesia (HP:0002304)1.86672767
111Agitation (HP:0000713)1.86402924
112Gait ataxia (HP:0002066)1.85563001
113Vertebral compression fractures (HP:0002953)1.85499058
114Hammertoe (HP:0001765)1.85482731
115Amyotrophic lateral sclerosis (HP:0007354)1.85045896
116Hypercortisolism (HP:0001578)1.84197236
117Clonus (HP:0002169)1.83559085
118Increased cerebral lipofuscin (HP:0011813)1.83241060
119Slow saccadic eye movements (HP:0000514)1.83066933
120Bowel incontinence (HP:0002607)1.82726851
121Elfin facies (HP:0004428)1.82081611
122Macroorchidism (HP:0000053)1.82042229
123Abnormal EKG (HP:0003115)1.81689530
124Distal sensory impairment (HP:0002936)1.81221990
125Intellectual disability, profound (HP:0002187)1.79976495
126J-shaped sella turcica (HP:0002680)1.79378752
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.79119653
128Rigidity (HP:0002063)1.79117790
129Abnormality of the corticospinal tract (HP:0002492)1.78416295
130Abnormality of the periventricular white matter (HP:0002518)1.77833299
131Abnormality of the salivary glands (HP:0010286)1.76041875
132Abnormal large intestine physiology (HP:0012700)1.75096152
133Axonal loss (HP:0003447)1.74761071
134Inability to walk (HP:0002540)1.74344961
135Polygenic inheritance (HP:0010982)1.74007081
136Decreased motor nerve conduction velocity (HP:0003431)1.73671413
137Achilles tendon contracture (HP:0001771)1.73481490
138Abnormality of saccadic eye movements (HP:0000570)1.72941557
139Diminished motivation (HP:0000745)1.72232654
140Dysostosis multiplex (HP:0000943)1.71548478
141Abnormality of the Achilles tendon (HP:0005109)1.69321240
142Thin bony cortex (HP:0002753)1.68924124
143Spinal canal stenosis (HP:0003416)1.68478047
144Interstitial pulmonary disease (HP:0006530)1.67136248
145Premature rupture of membranes (HP:0001788)1.66544505
146Dementia (HP:0000726)1.65233366
147Germ cell neoplasia (HP:0100728)1.64726621
148Patellar dislocation (HP:0002999)1.63042398
149Growth hormone excess (HP:0000845)1.62008974
150Back pain (HP:0003418)1.60279494
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.58684288
152Athetosis (HP:0002305)1.58344211
153Renal duplication (HP:0000075)1.56438568
154Personality changes (HP:0000751)1.55841800
155Ulnar bowing (HP:0003031)1.55802065
156Relative macrocephaly (HP:0004482)1.53546846
157Arterial tortuosity (HP:0005116)1.52698148
158Hypercalcemia (HP:0003072)1.52042668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.12059090
2NTRK34.47794901
3MAP3K94.18963852
4DAPK22.80846476
5KSR22.71457862
6MAP3K42.70804651
7PRKD32.66524621
8MINK12.59778246
9SMG12.54045218
10EEF2K2.50166036
11PAK62.37631219
12RIPK42.29081282
13MARK12.25221126
14ICK2.24394979
15CAMKK12.15455577
16SIK12.08077965
17MAP2K72.03206087
18CDK121.93844337
19NTRK11.90582446
20KSR11.81782254
21DAPK11.77109620
22NTRK21.77016266
23MAP2K41.76543752
24MAP3K121.67356090
25SIK21.66434239
26EPHA21.64328370
27ERN11.61766328
28MAP3K131.60651376
29TAOK11.59632720
30MAP3K21.59400221
31CDK51.58534933
32TESK11.52519966
33STK381.48839911
34ARAF1.43423571
35TYRO31.39487403
36FES1.38755697
37PKN21.30036448
38PLK21.25436649
39FGFR41.23193408
40PAK41.22058914
41IRAK31.15591576
42PRPF4B1.15441140
43LATS21.14537906
44NEK61.12698339
45GRK51.12468165
46RAF11.09976970
47CDK191.06942617
48RET1.05503079
49PRKCG1.04648789
50CAMK11.01248431
51ALK1.00240359
52PRKCH0.99242180
53PTK20.97950643
54CAMKK20.97171566
55STK110.94851980
56UHMK10.93453621
57TAOK20.92057703
58PTK2B0.90533077
59CDK180.90106423
60CDK150.88780081
61CDK140.87323609
62MST1R0.87198393
63TNIK0.85849107
64MAP3K10.84686169
65CAMK2A0.84471568
66PNCK0.82850553
67RIPK10.82469886
68PDK10.82452319
69TESK20.81250525
70MAPK130.80541135
71DMPK0.79672464
72CDK11A0.78802779
73MARK20.78669947
74SGK30.77792879
75PTK60.77397675
76PAK30.76339520
77MTOR0.74131823
78PDPK10.73684624
79SGK2230.72870894
80SGK4940.72870894
81CAMK1D0.71945855
82EPHB10.70495353
83RPS6KB20.70083217
84MAP3K110.69507597
85SGK10.69479406
86BRAF0.69304169
87SGK20.66826597
88PRKG20.66001525
89SIK30.65907861
90BMPR20.65421376
91LIMK10.65094115
92CAMK2B0.63130729
93NME20.62509335
94TRIB30.61936199
95MAP3K30.61412582
96NEK10.61184255
97CAMK1G0.58965979
98IRAK20.57949885
99MAP3K70.57095443
100MAPK120.56076842
101CAMK40.51811728
102MAP2K10.50679745
103TNK20.50646124
104FYN0.50592827
105ROCK20.50022084
106RPS6KA30.49896176
107LMTK20.49642311
108LRRK20.49492296
109PRKCZ0.48887074
110DYRK1A0.48717705
111CSNK1G20.48289782
112MAP3K100.47609882
113FER0.47094161
114PHKG20.47029337
115PHKG10.47029337
116CAMK2G0.46774748
117PINK10.46393177
118SCYL20.46200946
119MET0.45580093
120MAPK100.45372211
121PDGFRB0.44057411
122PAK20.43765946
123DAPK30.42863877
124FGR0.41560833
125MAP3K80.41291581
126TTN0.40943516
127BRSK10.40313935
128AKT20.40251340
129CASK0.39873009
130CDC42BPA0.38389497
131MAP2K20.37625492
132PDGFRA0.36831385
133DDR20.36604392
134MAPKAPK30.34876114
135OXSR10.34298438
136MAP3K60.34210404
137PRKD20.33939329
138MOS0.31505939
139RPS6KA20.31104702
140BMX0.29726415
141PRKCB0.29494489
142WNK10.28735249

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02671022
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96164811
3Olfactory transduction_Homo sapiens_hsa047402.84724659
4Long-term potentiation_Homo sapiens_hsa047202.70390435
5Circadian entrainment_Homo sapiens_hsa047132.56885447
6Amphetamine addiction_Homo sapiens_hsa050312.49885929
7GABAergic synapse_Homo sapiens_hsa047272.39500280
8Glutamatergic synapse_Homo sapiens_hsa047242.38470413
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34470377
10Morphine addiction_Homo sapiens_hsa050322.31040902
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19385119
12Dopaminergic synapse_Homo sapiens_hsa047282.13823177
13Salivary secretion_Homo sapiens_hsa049702.10616463
14Cholinergic synapse_Homo sapiens_hsa047251.95112341
15Insulin secretion_Homo sapiens_hsa049111.94952221
16Gastric acid secretion_Homo sapiens_hsa049711.91502250
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90827522
18Cocaine addiction_Homo sapiens_hsa050301.79043634
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71762716
20Renin secretion_Homo sapiens_hsa049241.71062559
21Oxytocin signaling pathway_Homo sapiens_hsa049211.69476005
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65101528
23Long-term depression_Homo sapiens_hsa047301.56411700
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54176474
25GnRH signaling pathway_Homo sapiens_hsa049121.52646636
26Calcium signaling pathway_Homo sapiens_hsa040201.50148794
27Nitrogen metabolism_Homo sapiens_hsa009101.43811148
28Serotonergic synapse_Homo sapiens_hsa047261.43252108
29Glioma_Homo sapiens_hsa052141.43012686
30Chronic myeloid leukemia_Homo sapiens_hsa052201.42552696
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38327145
32Gap junction_Homo sapiens_hsa045401.37555429
33Thyroid cancer_Homo sapiens_hsa052161.35940959
34Taste transduction_Homo sapiens_hsa047421.33499426
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33412266
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31009451
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.30306941
38cAMP signaling pathway_Homo sapiens_hsa040241.29755550
39Type II diabetes mellitus_Homo sapiens_hsa049301.27517877
40Estrogen signaling pathway_Homo sapiens_hsa049151.23462960
41Acute myeloid leukemia_Homo sapiens_hsa052211.16982333
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16649854
43ErbB signaling pathway_Homo sapiens_hsa040121.15459990
44Melanogenesis_Homo sapiens_hsa049161.07287346
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07011510
46Vitamin B6 metabolism_Homo sapiens_hsa007501.05413577
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03500702
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02040634
49Pancreatic cancer_Homo sapiens_hsa052121.01093119
50Dorso-ventral axis formation_Homo sapiens_hsa043201.00116811
51Axon guidance_Homo sapiens_hsa043600.99575501
52Bladder cancer_Homo sapiens_hsa052190.98870834
53Collecting duct acid secretion_Homo sapiens_hsa049660.97863719
54Adherens junction_Homo sapiens_hsa045200.95336561
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94718362
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.93143057
57VEGF signaling pathway_Homo sapiens_hsa043700.91997700
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.91864469
59Oocyte meiosis_Homo sapiens_hsa041140.90685005
60Notch signaling pathway_Homo sapiens_hsa043300.90507011
61Other glycan degradation_Homo sapiens_hsa005110.88561802
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.86718516
63Proteoglycans in cancer_Homo sapiens_hsa052050.86376499
64B cell receptor signaling pathway_Homo sapiens_hsa046620.85622452
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82671963
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.81992837
67Thyroid hormone synthesis_Homo sapiens_hsa049180.81776555
68Amoebiasis_Homo sapiens_hsa051460.81351552
69Choline metabolism in cancer_Homo sapiens_hsa052310.81305037
70Pancreatic secretion_Homo sapiens_hsa049720.81177808
71mTOR signaling pathway_Homo sapiens_hsa041500.81125316
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80729584
73Non-small cell lung cancer_Homo sapiens_hsa052230.80432801
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79110178
75Focal adhesion_Homo sapiens_hsa045100.75371748
76MAPK signaling pathway_Homo sapiens_hsa040100.75128091
77Pentose phosphate pathway_Homo sapiens_hsa000300.74238351
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74037340
79AMPK signaling pathway_Homo sapiens_hsa041520.73850129
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73384938
81Tight junction_Homo sapiens_hsa045300.73117612
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72159014
83Rap1 signaling pathway_Homo sapiens_hsa040150.70964989
84Lysosome_Homo sapiens_hsa041420.69803500
85Hepatitis C_Homo sapiens_hsa051600.69599364
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69010748
87Dilated cardiomyopathy_Homo sapiens_hsa054140.68548231
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.65878633
89Vibrio cholerae infection_Homo sapiens_hsa051100.65139294
90Ras signaling pathway_Homo sapiens_hsa040140.64150505
91Endometrial cancer_Homo sapiens_hsa052130.63767528
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63166339
93HIF-1 signaling pathway_Homo sapiens_hsa040660.62399103
94Glucagon signaling pathway_Homo sapiens_hsa049220.62069792
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60504435
96Shigellosis_Homo sapiens_hsa051310.58213627
97Renal cell carcinoma_Homo sapiens_hsa052110.58207321
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57250265
99Salmonella infection_Homo sapiens_hsa051320.57217960
100Prostate cancer_Homo sapiens_hsa052150.57144251
101* Endocytosis_Homo sapiens_hsa041440.56506933
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56429579
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54336466
104Type I diabetes mellitus_Homo sapiens_hsa049400.54282582
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54154618
106Chemokine signaling pathway_Homo sapiens_hsa040620.51838874
107Cardiac muscle contraction_Homo sapiens_hsa042600.49567469
108Prion diseases_Homo sapiens_hsa050200.49088309
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48962585
110Inositol phosphate metabolism_Homo sapiens_hsa005620.48272223
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47318976
112African trypanosomiasis_Homo sapiens_hsa051430.47126476
113Bile secretion_Homo sapiens_hsa049760.47092748
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47066071
115Wnt signaling pathway_Homo sapiens_hsa043100.47019016
116Insulin signaling pathway_Homo sapiens_hsa049100.46521877
117Phototransduction_Homo sapiens_hsa047440.46346065
118Alcoholism_Homo sapiens_hsa050340.45353035
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42740552
120Platelet activation_Homo sapiens_hsa046110.42558237
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42223769
122Prolactin signaling pathway_Homo sapiens_hsa049170.42133688
123Colorectal cancer_Homo sapiens_hsa052100.41326248
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40232459
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39091565
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36619193
127Circadian rhythm_Homo sapiens_hsa047100.36344936
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33796818
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31642355
130Ovarian steroidogenesis_Homo sapiens_hsa049130.31554604

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