ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	7.61637666
2	Golgi transport vesicle coating (GO:0048200)	7.61637666
3	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	6.60165674
4	protein retention in ER lumen (GO:0006621)	6.21325621
5	signal peptide processing (GO:0006465)	5.68748609
6	proteasome assembly (GO:0043248)	4.82522331
7	COPII vesicle coating (GO:0048208)	4.47116912
8	keratan sulfate catabolic process (GO:0042340)	4.28411309
9	collagen fibril organization (GO:0030199)	4.27478486
10	chondrocyte development (GO:0002063)	4.01820662
11	chondrocyte proliferation (GO:0035988)	3.98495304
12	nucleotide-sugar biosynthetic process (GO:0009226)	3.67576829
13	ribosome assembly (GO:0042255)	3.67084059
14	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.63919702
15	positive regulation of actin filament depolymerization (GO:0030836)	3.55525493
16	exocrine pancreas development (GO:0031017)	3.43984205
17	regulation of metalloenzyme activity (GO:0048552)	3.42976726
18	lipid particle organization (GO:0034389)	3.38199451
19	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.38181260
20	tRNA aminoacylation for protein translation (GO:0006418)	3.35452358
21	regulation of cellular amino acid metabolic process (GO:0006521)	3.33440604
22	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.32897001
23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.24497389
24	dermatan sulfate biosynthetic process (GO:0030208)	3.23421975
25	amino acid activation (GO:0043038)	3.23312388
26	tRNA aminoacylation (GO:0043039)	3.23312388
27	establishment of viral latency (GO:0019043)	3.20413936
28	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.19695816
29	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.19429113
30	vesicle coating (GO:0006901)	3.18815849
31	platelet dense granule organization (GO:0060155)	3.18271067
32	cellular response to vitamin D (GO:0071305)	3.17718949
33	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.15643593
34	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.12102397
35	negative regulation of ligase activity (GO:0051352)	3.12102397
36	cholesterol biosynthetic process (GO:0006695)	3.09631466
37	dermatan sulfate metabolic process (GO:0030205)	3.04162702
38	sterol biosynthetic process (GO:0016126)	2.99780014
39	type B pancreatic cell proliferation (GO:0044342)	2.97332740
40	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.96558750
41	protein N-linked glycosylation via asparagine (GO:0018279)	2.96401378
42	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.92954354
43	peptidyl-asparagine modification (GO:0018196)	2.90724279
44	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.88877229
45	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.88877229
46	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.88517859
47	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.87439873
48	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.87439873
49	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.87439873
50	fatty acid elongation (GO:0030497)	2.86825865
51	cartilage condensation (GO:0001502)	2.85743400
52	cell aggregation (GO:0098743)	2.85743400
53	positive regulation of nuclease activity (GO:0032075)	2.84419210
54	viral protein processing (GO:0019082)	2.83333653
55	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.81491968
56	cullin deneddylation (GO:0010388)	2.81349472
57	endoplasmic reticulum unfolded protein response (GO:0030968)	2.81114120
58	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.81049753
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.80572224
60	protein neddylation (GO:0045116)	2.80345135
61	membrane budding (GO:0006900)	2.79622113
62	response to redox state (GO:0051775)	2.79016334
63	sequestering of extracellular ligand from receptor (GO:0035581)	2.77893591
64	endothelial cell morphogenesis (GO:0001886)	2.77243118
65	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.73978202
66	peptidyl-histidine modification (GO:0018202)	2.73872712
67	cellular response to unfolded protein (GO:0034620)	2.73352177
68	4-hydroxyproline metabolic process (GO:0019471)	2.72508001
69	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71867199
70	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71867199
71	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71162115
72	protein heterotrimerization (GO:0070208)	2.70719287
73	ER to Golgi vesicle-mediated transport (GO:0006888)	2.70719043
74	ER overload response (GO:0006983)	2.70593858
75	protein N-linked glycosylation (GO:0006487)	2.70070962
76	peptidyl-proline hydroxylation (GO:0019511)	2.69736071
77	collagen metabolic process (GO:0032963)	2.68193860
78	embryonic skeletal joint morphogenesis (GO:0060272)	2.67647708
79	regulation of integrin-mediated signaling pathway (GO:2001044)	2.67221175
80	L-serine transport (GO:0015825)	2.66898830
81	virion assembly (GO:0019068)	2.66376293
82	DNA damage response, detection of DNA damage (GO:0042769)	2.65855043
83	regulation of nuclease activity (GO:0032069)	2.65831077
84	mannosylation (GO:0097502)	2.65750796
85	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.65678775
86	positive regulation of ligase activity (GO:0051351)	2.65362918
87	fibril organization (GO:0097435)	2.65071021
88	cellular response to vitamin (GO:0071295)	2.64531449
89	positive regulation of extracellular matrix organization (GO:1903055)	2.64420312
90	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.63918275
91	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.61992364
92	skin morphogenesis (GO:0043589)	2.61913739
93	protein deneddylation (GO:0000338)	2.61732921
94	mesenchyme morphogenesis (GO:0072132)	2.61408778
95	cellular response to topologically incorrect protein (GO:0035967)	2.60737603
96	collagen catabolic process (GO:0030574)	2.60352477
97	cell adhesion mediated by integrin (GO:0033627)	2.59903052
98	de novo protein folding (GO:0006458)	2.59827953
99	peptidyl-cysteine modification (GO:0018198)	2.58018146
100	notochord development (GO:0030903)	2.57060599
101	protein K11-linked ubiquitination (GO:0070979)	2.56878104
102	protein maturation by protein folding (GO:0022417)	2.56234385
103	intra-Golgi vesicle-mediated transport (GO:0006891)	2.55637210
104	positive regulation of receptor biosynthetic process (GO:0010870)	2.55460466
105	positive regulation of cartilage development (GO:0061036)	2.54738601
106	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.54369404
107	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.54204583
108	aldehyde catabolic process (GO:0046185)	2.54163614
109	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.52996353
110	tricarboxylic acid cycle (GO:0006099)	2.52535298
111	multicellular organismal catabolic process (GO:0044243)	2.52389346
112	ER-nucleus signaling pathway (GO:0006984)	2.51901104
113	regulation of cofactor metabolic process (GO:0051193)	2.51809068
114	regulation of coenzyme metabolic process (GO:0051196)	2.51809068
115	negative regulation of chondrocyte differentiation (GO:0032331)	2.51572215
116	endodermal cell differentiation (GO:0035987)	2.51254028
117	negative regulation of cartilage development (GO:0061037)	2.50671213
118	regulation of interleukin-8 secretion (GO:2000482)	2.50095575
119	chondroitin sulfate biosynthetic process (GO:0030206)	2.49550229
120	de novo posttranslational protein folding (GO:0051084)	2.49328611
121	ventricular cardiac muscle cell development (GO:0055015)	2.48716394
122	extracellular fibril organization (GO:0043206)	2.47738625
123	extracellular matrix disassembly (GO:0022617)	2.46842511
124	positive regulation of mitochondrial fission (GO:0090141)	2.46621693
125	amino acid salvage (GO:0043102)	2.45497026
126	L-methionine salvage (GO:0071267)	2.45497026
127	L-methionine biosynthetic process (GO:0071265)	2.45497026
128	multicellular organismal metabolic process (GO:0044236)	2.45484081
129	nucleotide-sugar metabolic process (GO:0009225)	2.45249381
130	multicellular organismal macromolecule metabolic process (GO:0044259)	2.45146591
131	negative regulation of keratinocyte proliferation (GO:0010839)	2.44423367
132	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.43792382
133	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.43792382
134	establishment of integrated proviral latency (GO:0075713)	2.43551447
135	sequestering of metal ion (GO:0051238)	2.42542894
136	C-terminal protein amino acid modification (GO:0018410)	2.42384369
137	regulation of ligase activity (GO:0051340)	2.42117890
138	mesodermal cell differentiation (GO:0048333)	2.41876803
139	aspartate family amino acid biosynthetic process (GO:0009067)	2.41860302
140	neural crest cell development (GO:0014032)	2.41573885
141	DNA double-strand break processing (GO:0000729)	2.40927084
142	nucleotide transmembrane transport (GO:1901679)	2.39933765
143	positive regulation of epithelial to mesenchymal transition (GO:0010718)	2.38804121
144	peptidyl-proline modification (GO:0018208)	2.36397072
145	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.35901678
146	protein refolding (GO:0042026)	2.35831216
147	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)	2.35041028
148	C-terminal protein lipidation (GO:0006501)	2.34762828
149	negative regulation of protein ubiquitination (GO:0031397)	2.33815861
150	7-methylguanosine mRNA capping (GO:0006370)	2.33168944
151	response to endoplasmic reticulum stress (GO:0034976)	2.33039387
152	regulation of cellular amine metabolic process (GO:0033238)	2.32025474
153	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.31967093
154	chaperone-mediated protein folding (GO:0061077)	2.31697678
155	cell proliferation involved in kidney development (GO:0072111)	2.31502870
156	cellular response to hepatocyte growth factor stimulus (GO:0035729)	2.31363016
157	response to hepatocyte growth factor (GO:0035728)	2.31363016
158	wound healing, spreading of epidermal cells (GO:0035313)	2.31245609
159	negative regulation of stem cell proliferation (GO:2000647)	2.30125792
160	bone trabecula formation (GO:0060346)	2.30023851
161	limb bud formation (GO:0060174)	2.29266985
162	protein peptidyl-prolyl isomerization (GO:0000413)	2.28818830
163	endocardial cushion morphogenesis (GO:0003203)	2.27781319
164	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.25677825
165	negative regulation of glycogen biosynthetic process (GO:0045719)	2.23285616
166	cartilage development (GO:0051216)	2.22758898
167	lipopolysaccharide biosynthetic process (GO:0009103)	2.22250277
168	extracellular matrix organization (GO:0030198)	2.21057409

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRIM28_21343339_ChIP-Seq_HEK293_Human	6.21026336
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.85440572
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.65250373
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.45893023
5	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.43564758
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.38635092
7	CLOCK_20551151_ChIP-Seq_293T_Human	3.06324454
8	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.97343896
9	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.88573727
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85665564
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.58457221
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57377837
13	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	2.45040106
14	* ELK1_19687146_ChIP-ChIP_HELA_Human	2.21725336
15	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.20422665
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.19397266
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.10036970
18	SOX2_20726797_ChIP-Seq_SW620_Human	2.08214202
19	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.07777708
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07717109
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.05585593
22	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.04824340
23	CJUN_26792858_Chip-Seq_BT549_Human	2.03964406
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.01497273
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.01010805
26	* ELK1_22589737_ChIP-Seq_MCF10A_Human	1.98131144
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97720870
28	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.93286751
29	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.90884250
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.88730695
31	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.87510370
32	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.86282581
33	BRD4_25478319_ChIP-Seq_HGPS_Human	1.85507641
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.77205989
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76010261
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75504858
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74992613
38	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.74911247
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73110393
40	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.68954693
41	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.68954693
42	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.66753082
43	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.66753082
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65115080
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.64155356
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.63911351
47	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.63317944
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.62812403
49	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.61975102
50	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.57097822
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56973597
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.55786269
53	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.55624330
54	* EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53431270
55	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.53352942
56	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.50853730
57	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.49842801
58	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.47575580
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45810274
60	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.45406832
61	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.44639113
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41561887
63	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.41493927
64	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41156048
65	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.40444151
66	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.39318810
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.38932609
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38850116
69	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.36799496
70	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.34901767
71	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.34037051
72	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.31890304
73	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.31779279
74	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.30849782
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29380520
76	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.28706683
77	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27864239
78	EWS_26573619_Chip-Seq_HEK293_Human	1.26370260
79	AR_21909140_ChIP-Seq_LNCAP_Human	1.26047858
80	TFEB_21752829_ChIP-Seq_HELA_Human	1.24228449
81	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.24087204
82	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.23531625
83	* NANOG_16153702_ChIP-ChIP_HESCs_Human	1.23333858
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23087521
85	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.22924439
86	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.21149150
87	* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20098178
88	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19703276
89	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19656611
90	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.19002765
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18951620
92	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17177346
93	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16703265
94	P300_19829295_ChIP-Seq_ESCs_Human	1.16565909
95	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.14738196
96	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12834170
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.11747077
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.11446512
99	* VDR_23849224_ChIP-Seq_CD4+_Human	1.09700077
100	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.09117230
101	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.08782671
102	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08666655
103	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.08203381
104	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.06733356
105	GABP_19822575_ChIP-Seq_HepG2_Human	1.05968935
106	MYC_18940864_ChIP-ChIP_HL60_Human	1.05470439
107	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.05018237
108	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04477103
109	EOMES_21245162_ChIP-Seq_HESCs_Human	1.04361639
110	FUS_26573619_Chip-Seq_HEK293_Human	1.02312527
111	* XRN2_22483619_ChIP-Seq_HELA_Human	1.02136410
112	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.01180994
113	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.00420050
114	GATA4_25053715_ChIP-Seq_YYC3_Human	0.98834965
115	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98506852
116	* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97446433
117	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.96990934
118	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.96766306
119	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96514677
120	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96433289
121	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.95156305
122	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95080512
123	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.94953825
124	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.94557599
125	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.93981869
126	* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.93842142
127	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.93733839
128	CDX2_22108803_ChIP-Seq_LS180_Human	0.93554702
129	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92905714
130	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.92811308
131	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91901472
132	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.90986542
133	* NFI_21473784_ChIP-Seq_ESCs_Mouse	0.90396811
134	GBX2_23144817_ChIP-Seq_PC3_Human	0.90121315
135	GATA1_22025678_ChIP-Seq_K562_Human	0.88719379
136	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.88356386
137	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.88305163
138	* TTF2_22483619_ChIP-Seq_HELA_Human	0.88014836
139	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.87076718
140	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.85740221
141	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85062856
142	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83590017
143	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.83512136
144	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82738339
145	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.82639003
146	TAF15_26573619_Chip-Seq_HEK293_Human	0.81810867

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	5.19623394
2	MP0005503_abnormal_tendon_morphology	4.64430447
3	MP0005275_abnormal_skin_tensile	3.24524228
4	MP0006054_spinal_hemorrhage	2.87822876
5	MP0003950_abnormal_plasma_membrane	2.75597611
6	MP0004272_abnormal_basement_membrane	2.59298660
7	MP0009384_cardiac_valve_regurgitation	2.57542977
8	MP0009250_abnormal_appendicular_skeleto	2.49143696
9	MP0002102_abnormal_ear_morphology	2.48542856
10	MP0003279_aneurysm	2.46132020
11	MP0004134_abnormal_chest_morphology	2.42983838
12	MP0003705_abnormal_hypodermis_morpholog	2.30180604
13	MP0002282_abnormal_trachea_morphology	2.22560327
14	MP0001529_abnormal_vocalization	2.15900725
15	MP0005508_abnormal_skeleton_morphology	2.14012298
16	MP0002933_joint_inflammation	2.12519842
17	MP0001542_abnormal_bone_strength	2.11547603
18	MP0010030_abnormal_orbit_morphology	2.03623544
19	MP0000163_abnormal_cartilage_morphology	1.98440111
20	MP0002877_abnormal_melanocyte_morpholog	1.96514251
21	MP0005220_abnormal_exocrine_pancreas	1.90652155
22	MP0001958_emphysema	1.87282836
23	MP0003806_abnormal_nucleotide_metabolis	1.76647709
24	MP0005084_abnormal_gallbladder_morpholo	1.73030697
25	MP0002896_abnormal_bone_mineralization	1.70699647
26	MP0001879_abnormal_lymphatic_vessel	1.69984638
27	MP0005390_skeleton_phenotype	1.65571253
28	MP0003385_abnormal_body_wall	1.64927843
29	MP0002115_abnormal_skeleton_extremities	1.64167686
30	MP0003942_abnormal_urinary_system	1.63599230
31	MP0009053_abnormal_anal_canal	1.62131359
32	MP0002938_white_spotting	1.59480480
33	MP0002113_abnormal_skeleton_development	1.57038124
34	MP0008789_abnormal_olfactory_epithelium	1.54702607
35	MP0004957_abnormal_blastocyst_morpholog	1.54417728
36	MP0010368_abnormal_lymphatic_system	1.53697856
37	MP0008932_abnormal_embryonic_tissue	1.53506021
38	MP0002295_abnormal_pulmonary_circulatio	1.51296797
39	MP0000049_abnormal_middle_ear	1.48313039
40	MP0003890_abnormal_embryonic-extraembry	1.45016647
41	MP0001533_abnormal_skeleton_physiology	1.37669464
42	MP0002163_abnormal_gland_morphology	1.37269370
43	MP0003795_abnormal_bone_structure	1.35850372
44	MP0005023_abnormal_wound_healing	1.31426692
45	MP0003566_abnormal_cell_adhesion	1.29145484
46	MP0003122_maternal_imprinting	1.28480115
47	MP0008058_abnormal_DNA_repair	1.27033119
48	MP0002060_abnormal_skin_morphology	1.24209424
49	MP0000678_abnormal_parathyroid_gland	1.22084823
50	MP0006276_abnormal_autonomic_nervous	1.21297814
51	MP0003786_premature_aging	1.20795604
52	MP0010352_gastrointestinal_tract_polyps	1.19586059
53	MP0001299_abnormal_eye_distance/	1.19327740
54	MP0000749_muscle_degeneration	1.18716592
55	MP0000566_synostosis	1.16621197
56	MP0002932_abnormal_joint_morphology	1.16454679
57	MP0005394_taste/olfaction_phenotype	1.16420929
58	MP0005499_abnormal_olfactory_system	1.16420929
59	MP0002109_abnormal_limb_morphology	1.14356566
60	MP0003221_abnormal_cardiomyocyte_apopto	1.14079876
61	MP0000013_abnormal_adipose_tissue	1.11895615
62	MP0001243_abnormal_dermal_layer	1.10817274
63	MP0003718_maternal_effect	1.10740448
64	MP0003755_abnormal_palate_morphology	1.09656613
65	MP0005171_absent_coat_pigmentation	1.08544719
66	MP0000516_abnormal_urinary_system	1.07873559
67	MP0005367_renal/urinary_system_phenotyp	1.07873559
68	MP0002090_abnormal_vision	1.07594785
69	MP0000613_abnormal_salivary_gland	1.06081264
70	MP0005197_abnormal_uvea_morphology	1.05515851
71	MP0000537_abnormal_urethra_morphology	1.04684879
72	MP0000358_abnormal_cell_content/	1.04439710
73	MP0003693_abnormal_embryo_hatching	1.04340035
74	MP0003724_increased_susceptibility_to	1.03467837
75	MP0000767_abnormal_smooth_muscle	1.03447656
76	MP0001270_distended_abdomen	1.02014366
77	MP0009780_abnormal_chondrocyte_physiolo	1.01124615
78	MP0002108_abnormal_muscle_morphology	1.01035658
79	MP0005257_abnormal_intraocular_pressure	0.99851303
80	MP0000534_abnormal_ureter_morphology	0.99373511
81	MP0008007_abnormal_cellular_replicative	0.98981433
82	MP0002254_reproductive_system_inflammat	0.98607572
83	MP0000343_altered_response_to	0.98342985
84	MP0002116_abnormal_craniofacial_bone	0.98302468
85	MP0000762_abnormal_tongue_morphology	0.97563427
86	MP0003943_abnormal_hepatobiliary_system	0.97392568
87	MP0002089_abnormal_postnatal_growth/wei	0.97246884
88	MP0002084_abnormal_developmental_patter	0.97211232
89	MP0003123_paternal_imprinting	0.97133420
90	MP0009697_abnormal_copulation	0.96880502
91	MP0001348_abnormal_lacrimal_gland	0.96434162
92	MP0002138_abnormal_hepatobiliary_system	0.94657350
93	MP0000647_abnormal_sebaceous_gland	0.94486811
94	MP0005187_abnormal_penis_morphology	0.94125747
95	MP0002998_abnormal_bone_remodeling	0.94098377
96	MP0003091_abnormal_cell_migration	0.94072809
97	MP0000858_altered_metastatic_potential	0.92748997
98	MP0005379_endocrine/exocrine_gland_phen	0.92463870
99	MP0003186_abnormal_redox_activity	0.89488103
100	MP0008004_abnormal_stomach_pH	0.88921833
101	MP0006072_abnormal_retinal_apoptosis	0.88821731
102	MP0000372_irregular_coat_pigmentation	0.88606993
103	MP0001915_intracranial_hemorrhage	0.88570603
104	MP0005164_abnormal_response_to	0.88037388
105	MP0004133_heterotaxia	0.87628340
106	MP0001293_anophthalmia	0.86139518
107	MP0003937_abnormal_limbs/digits/tail_de	0.85976593
108	MP0000681_abnormal_thyroid_gland	0.85619397
109	MP0010386_abnormal_urinary_bladder	0.85562429
110	MP0001944_abnormal_pancreas_morphology	0.85410425
111	MP0005360_urolithiasis	0.84547945
112	MP0000751_myopathy	0.82890680
113	MP0004782_abnormal_surfactant_physiolog	0.82002607
114	MP0002751_abnormal_autonomic_nervous	0.81605191
115	MP0003283_abnormal_digestive_organ	0.80874734
116	MP0004264_abnormal_extraembryonic_tissu	0.80600933
117	MP0003868_abnormal_feces_composition	0.79401479
118	MP0002233_abnormal_nose_morphology	0.79348597
119	MP0008260_abnormal_autophagy	0.77503869
120	MP0003115_abnormal_respiratory_system	0.77241700
121	MP0000432_abnormal_head_morphology	0.76958590
122	MP0005085_abnormal_gallbladder_physiolo	0.76733957
123	MP0001346_abnormal_lacrimal_gland	0.76286970
124	MP0001177_atelectasis	0.75995818
125	MP0005623_abnormal_meninges_morphology	0.75988472
126	MP0004215_abnormal_myocardial_fiber	0.75735244
127	MP0005248_abnormal_Harderian_gland	0.75645837
128	MP0002177_abnormal_outer_ear	0.74347935
129	MP0003011_delayed_dark_adaptation	0.73087231
130	MP0002111_abnormal_tail_morphology	0.73062186
131	MP0002249_abnormal_larynx_morphology	0.72562096
132	MP0003941_abnormal_skin_development	0.72309718
133	MP0005408_hypopigmentation	0.72023186
134	MP0001175_abnormal_lung_morphology	0.71949417
135	MP0005253_abnormal_eye_physiology	0.70310177
136	MP0003935_abnormal_craniofacial_develop	0.70136438
137	MP0001764_abnormal_homeostasis	0.69910198
138	MP0002085_abnormal_embryonic_tissue	0.68985878
139	MP0003448_altered_tumor_morphology	0.68306466
140	MP0005501_abnormal_skin_physiology	0.67814693
141	MP0002234_abnormal_pharynx_morphology	0.67009547
142	MP0000639_abnormal_adrenal_gland	0.66572607
143	MP0003195_calcinosis	0.65106373
144	MP0003119_abnormal_digestive_system	0.64909932
145	MP0001697_abnormal_embryo_size	0.64901055
146	MP0009379_abnormal_foot_pigmentation	0.64544656
147	MP0010771_integument_phenotype	0.61820148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Epiphyseal dysplasia (HP:0002656)	5.69776246
2	Irregular epiphyses (HP:0010582)	4.98395254
3	Protrusio acetabuli (HP:0003179)	4.80175659
4	Abnormality of glycolysis (HP:0004366)	4.14333096
5	Vitreoretinal degeneration (HP:0000655)	4.05168998
6	Increased serum pyruvate (HP:0003542)	4.03436410
7	Cupped ribs (HP:0000887)	3.95970244
8	Premature rupture of membranes (HP:0001788)	3.95019611
9	Cervical subluxation (HP:0003308)	3.88287001
10	Small epiphyses (HP:0010585)	3.75327487
11	Upper limb muscle weakness (HP:0003484)	3.67374630
12	Abnormal tarsal ossification (HP:0008369)	3.66232199
13	Metaphyseal dysplasia (HP:0100255)	3.51398959
14	Flat capital femoral epiphysis (HP:0003370)	3.44395092
15	Delayed epiphyseal ossification (HP:0002663)	3.40559964
16	Neonatal short-limb short stature (HP:0008921)	3.37948070
17	Vertebral compression fractures (HP:0002953)	3.24264573
18	Hand muscle atrophy (HP:0009130)	3.21316503
19	Beaking of vertebral bodies (HP:0004568)	3.19638318
20	Hypoplastic ischia (HP:0003175)	3.13326895
21	Genu varum (HP:0002970)	3.07129668
22	Abnormality of dentin (HP:0010299)	3.04952878
23	Platyspondyly (HP:0000926)	3.01700315
24	Soft skin (HP:0000977)	3.01573602
25	Abnormal foot bone ossification (HP:0010675)	2.99456784
26	Reduced antithrombin III activity (HP:0001976)	2.96320986
27	Osteoarthritis (HP:0002758)	2.91156772
28	Aortic aneurysm (HP:0004942)	2.91088197
29	Mild short stature (HP:0003502)	2.90635171
30	Irregular vertebral endplates (HP:0003301)	2.90459790
31	Tetraparesis (HP:0002273)	2.89386521
32	Abnormality of the vertebral endplates (HP:0005106)	2.88241300
33	Metaphyseal cupping (HP:0003021)	2.86785051
34	Delayed gross motor development (HP:0002194)	2.84917407
35	Wormian bones (HP:0002645)	2.78155388
36	Thoracolumbar scoliosis (HP:0002944)	2.76791529
37	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.76344034
38	Coxa vara (HP:0002812)	2.74346022
39	Abnormality of the ischium (HP:0003174)	2.72799236
40	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.68296099
41	Abnormality of femoral epiphyses (HP:0006499)	2.68296099
42	Vascular tortuosity (HP:0004948)	2.66923797
43	Flattened epiphyses (HP:0003071)	2.66294396
44	Aortic dissection (HP:0002647)	2.66054259
45	Flat acetabular roof (HP:0003180)	2.65581076
46	Biconcave vertebral bodies (HP:0004586)	2.59804214
47	Abnormality of the anterior horn cell (HP:0006802)	2.56809937
48	Degeneration of anterior horn cells (HP:0002398)	2.56809937
49	Postnatal microcephaly (HP:0005484)	2.54127055
50	Congenital primary aphakia (HP:0007707)	2.54119226
51	Abnormality of the acetabulum (HP:0003170)	2.53376037
52	Medial flaring of the eyebrow (HP:0010747)	2.48925774
53	Abnormality of carpal bone ossification (HP:0006257)	2.47806531
54	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.44046061
55	Methylmalonic acidemia (HP:0002912)	2.42207098
56	Abnormal gallbladder physiology (HP:0012438)	2.39053384
57	Cholecystitis (HP:0001082)	2.39053384
58	Abnormality of the femoral head (HP:0003368)	2.38478453
59	Distal upper limb amyotrophy (HP:0007149)	2.38286033
60	Upper limb amyotrophy (HP:0009129)	2.38286033
61	Gait imbalance (HP:0002141)	2.37664080
62	Hepatoblastoma (HP:0002884)	2.31623043
63	Disproportionate short-trunk short stature (HP:0003521)	2.29881989
64	Joint stiffness (HP:0001387)	2.29850213
65	Follicular hyperkeratosis (HP:0007502)	2.29403694
66	Hypoplastic pelvis (HP:0008839)	2.28614252
67	Nephrogenic diabetes insipidus (HP:0009806)	2.28376099
68	Blue sclerae (HP:0000592)	2.28286567
69	Abnormal pancreas size (HP:0012094)	2.27763597
70	Acute necrotizing encephalopathy (HP:0006965)	2.25354485
71	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.25191400
72	Absent epiphyses (HP:0010577)	2.25191400
73	Abnormality of incisor morphology (HP:0011063)	2.21795333
74	Enlarged epiphyses (HP:0010580)	2.20562890
75	Metaphyseal irregularity (HP:0003025)	2.18392012
76	Arterial tortuosity (HP:0005116)	2.16419561
77	Vertebral hypoplasia (HP:0008417)	2.15414431
78	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.15414431
79	Hypoplasia of the odontoid process (HP:0003311)	2.14488962
80	Acute encephalopathy (HP:0006846)	2.13608108
81	Glossoptosis (HP:0000162)	2.13458954
82	Exostoses (HP:0100777)	2.12653061
83	Abnormality of the distal phalanges of the toes (HP:0010182)	2.11561848
84	Short femoral neck (HP:0100864)	2.10070394
85	Redundant skin (HP:0001582)	2.09650045
86	Mesomelia (HP:0003027)	2.09509988
87	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08336179
88	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08336179
89	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.07824939
90	Type I transferrin isoform profile (HP:0003642)	2.07118122
91	Abnormal vertebral ossification (HP:0100569)	2.06528621
92	Dilatation of the ascending aorta (HP:0005111)	2.05349167
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05030303
94	Abnormality of alanine metabolism (HP:0010916)	2.05030303
95	Hyperalaninemia (HP:0003348)	2.05030303
96	Abnormal protein glycosylation (HP:0012346)	2.04958012
97	Abnormal glycosylation (HP:0012345)	2.04958012
98	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04958012
99	Abnormal protein N-linked glycosylation (HP:0012347)	2.04958012
100	Atrophic scars (HP:0001075)	2.04514846
101	Abnormality of methionine metabolism (HP:0010901)	2.03949190
102	Ovoid vertebral bodies (HP:0003300)	2.03578859
103	Methylmalonic aciduria (HP:0012120)	2.03450027
104	Intrahepatic cholestasis (HP:0001406)	2.01174117
105	Secondary amenorrhea (HP:0000869)	2.00039267
106	Spondylolisthesis (HP:0003302)	1.99260007
107	Decreased skull ossification (HP:0004331)	1.98660525
108	Spinal cord compression (HP:0002176)	1.98322276
109	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.97785734
110	Micromelia (HP:0002983)	1.96870308
111	Increased CSF lactate (HP:0002490)	1.95151984
112	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95085621
113	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.95044416
114	Broad long bones (HP:0005622)	1.94261195
115	Abnormal hand bone ossification (HP:0010660)	1.93806972
116	Vaginal atresia (HP:0000148)	1.92979003
117	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.92889897
118	Abnormality of the musculature of the pelvis (HP:0001469)	1.92314150
119	Abnormality of the hip-girdle musculature (HP:0001445)	1.92314150
120	Genital tract atresia (HP:0001827)	1.92162756
121	Abnormal cartilage morphology (HP:0002763)	1.91132585
122	Shoulder girdle muscle weakness (HP:0003547)	1.90081082
123	Hepatocellular necrosis (HP:0001404)	1.89799530
124	Proximal tubulopathy (HP:0000114)	1.89692215
125	Hepatic necrosis (HP:0002605)	1.89621305
126	Abnormal ossification of hand bones (HP:0005921)	1.88886422
127	Patchy hypopigmentation of hair (HP:0011365)	1.88302954
128	Overgrowth (HP:0001548)	1.88002872
129	Protuberant abdomen (HP:0001538)	1.87004609
130	Progressive macrocephaly (HP:0004481)	1.86737084
131	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.86500235
132	Abnormality of the fetal cardiovascular system (HP:0010948)	1.86400459
133	Abnormal umbilical cord blood vessels (HP:0011403)	1.86400459
134	Single umbilical artery (HP:0001195)	1.86400459
135	Bifid tongue (HP:0010297)	1.86171348
136	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.85311266
137	Arthropathy (HP:0003040)	1.83858056
138	Abnormality of the odontoid process (HP:0003310)	1.83783665
139	Ankle contracture (HP:0006466)	1.83711349
140	Broad phalanx (HP:0006009)	1.83527491
141	Neonatal respiratory distress (HP:0002643)	1.82731850
142	Spinal rigidity (HP:0003306)	1.82484732
143	Peritonitis (HP:0002586)	1.82313446
144	Bladder diverticulum (HP:0000015)	1.81752414
145	Shallow orbits (HP:0000586)	1.81359823
146	Coxa valga (HP:0002673)	1.80975642
147	Decreased testicular size (HP:0008734)	1.79852043
148	Entropion (HP:0000621)	1.79553259
149	Hypothermia (HP:0002045)	1.78602238
150	Short nail (HP:0001799)	1.78500541
151	Cerebral hypomyelination (HP:0006808)	1.78485519
152	Ectopia lentis (HP:0001083)	1.76847529
153	Abnormal delivery (HP:0001787)	1.75521737
154	Wide anterior fontanel (HP:0000260)	1.74618931
155	Tongue fasciculations (HP:0001308)	1.73618649
156	Cortical dysplasia (HP:0002539)	1.72726120
157	Abnormality of the umbilical cord (HP:0010881)	1.72504272
158	Cerebral edema (HP:0002181)	1.71158997
159	Microglossia (HP:0000171)	1.70812067
160	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.69783121
161	Stenosis of the external auditory canal (HP:0000402)	1.69567828
162	Short tibia (HP:0005736)	1.69339684
163	Hydroxyprolinuria (HP:0003080)	1.67626716
164	Abnormality of proline metabolism (HP:0010907)	1.67626716
165	Broad foot (HP:0001769)	1.65457302
166	Limb-girdle muscle atrophy (HP:0003797)	1.65115633
167	Abnormalities of placenta or umbilical cord (HP:0001194)	1.64890036
168	Mitochondrial inheritance (HP:0001427)	1.64686309
169	Increased serum lactate (HP:0002151)	1.63686912
170	Poor head control (HP:0002421)	1.59983399
171	Generalized aminoaciduria (HP:0002909)	1.58121058
172	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.57172220
173	Adrenal hypoplasia (HP:0000835)	1.56978148
174	Abnormality of the labia (HP:0000058)	1.56877526
175	Abnormality of serum amino acid levels (HP:0003112)	1.56846009
176	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.56479152
177	Keratoconus (HP:0000563)	1.54787951
178	Increased corneal curvature (HP:0100692)	1.54787951
179	Abnormality of the intrinsic pathway (HP:0010989)	1.54653724
180	Poor suck (HP:0002033)	1.53461600
181	Nonimmune hydrops fetalis (HP:0001790)	1.53446518

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.19578472
2	ERBB3	3.52398634
3	MAP4K2	3.36157850
4	TESK1	3.15711156
5	LIMK1	2.76645428
6	EPHA3	2.58687654
7	PIM2	2.51040541
8	MAP3K3	2.49131988
9	DDR2	2.45247385
10	MAP3K12	2.44502228
11	ERN1	2.09653492
12	FRK	2.08137255
13	RPS6KA4	2.06967045
14	NEK1	1.98430535
15	PDK2	1.98393670
16	PASK	1.94658693
17	TGFBR1	1.85995632
18	IRAK1	1.85678018
19	EIF2AK3	1.80882465
20	NUAK1	1.76425253
21	STK38L	1.74882820
22	MST4	1.73036851
23	WNK3	1.72122548
24	LATS1	1.67486050
25	NEK9	1.64192578
26	BRSK2	1.63061209
27	BCR	1.54026740
28	EPHB2	1.52534641
29	NME2	1.51095448
30	IRAK4	1.48786264
31	EIF2AK1	1.48089332
32	MAPK15	1.48018039
33	ACVR1B	1.46898695
34	MKNK1	1.44743390
35	ERBB4	1.39711847
36	BMPR1B	1.32941487
37	TBK1	1.31074429
38	MAP3K14	1.27632810
39	INSRR	1.26572640
40	PBK	1.24227515
41	EPHA2	1.20929761
42	PTK2	1.20311188
43	SIK3	1.19938495
44	PIK3CG	1.19221117
45	CSNK1G3	1.18215489
46	DYRK2	1.16362120
47	FLT3	1.16241389
48	TESK2	1.14876764
49	TTK	1.14025994
50	CSNK1G1	1.12357519
51	CHUK	1.11538403
52	MYLK	1.10826509
53	CSNK1A1L	1.09604117
54	NLK	1.09275702
55	WEE1	1.06013665
56	PRKG2	1.05621519
57	TAOK2	1.03856390
58	KDR	1.01554767
59	STK24	1.00082166
60	IRAK3	0.97985358
61	JAK3	0.97258122
62	FER	0.93956073
63	CSNK1G2	0.92604285
64	VRK1	0.91950856
65	MST1R	0.91209413
66	IRAK2	0.88522469
67	PLK4	0.85850277
68	MAP3K5	0.85784331
69	IKBKB	0.85498130
70	DYRK3	0.85225163
71	PAK2	0.84982782
72	VRK2	0.83953409
73	MET	0.83849114
74	PLK2	0.83021300
75	PRKCE	0.83008312
76	PIK3CA	0.82814371
77	PDGFRA	0.80048452
78	CDK8	0.79290766
79	MKNK2	0.79260245
80	TGFBR2	0.77215325
81	TRIB3	0.74083176
82	PAK3	0.73983471
83	STK3	0.73964591
84	PLK1	0.72659118
85	STK16	0.72523691
86	DYRK1B	0.72479039
87	GRK1	0.71700299
88	IKBKE	0.71669878
89	LMTK2	0.71240182
90	MINK1	0.70760525
91	EIF2AK2	0.70690078
92	MAPKAPK5	0.70066479
93	TRPM7	0.69990854
94	PLK3	0.68570936
95	ROCK1	0.66277694
96	TEC	0.65181491
97	KSR1	0.63969504
98	MAPK13	0.63270761
99	SRPK1	0.61999066
100	BUB1	0.61615364
101	LRRK2	0.61102405
102	PAK4	0.60681532
103	ILK	0.59901538
104	ABL2	0.59881374
105	RPS6KB2	0.59480306
106	FGFR1	0.59400334
107	BCKDK	0.59382067
108	NME1	0.56865623
109	BRSK1	0.56150277
110	TNIK	0.55726689
111	PTK6	0.55458905
112	MAP2K7	0.55178329
113	STK39	0.55026109
114	ZAK	0.51938108
115	MAP2K2	0.50303036
116	AKT3	0.47546432
117	TSSK6	0.47537760
118	SCYL2	0.47030322
119	MAP3K4	0.46872840
120	ROCK2	0.45846459
121	SIK1	0.44405192
122	NEK6	0.43777732
123	MAPKAPK2	0.43448132
124	ADRBK2	0.42559485
125	EPHB1	0.42219601
126	LATS2	0.41991711
127	PNCK	0.41580494
128	ADRBK1	0.40854297
129	MAPKAPK3	0.40434275
130	TIE1	0.40433949
131	CASK	0.39709581
132	IGF1R	0.38141868
133	ZAP70	0.37572504
134	MAP3K11	0.36979864
135	MAP3K2	0.36305951
136	MAP2K1	0.36171746
137	CDK14	0.35687880
138	CDK18	0.34472206
139	CSNK2A1	0.33058216
140	OXSR1	0.31785949
141	CDK6	0.31428852
142	PTK2B	0.31078998
143	GSK3A	0.28673315
144	GRK7	0.27594185
145	PAK1	0.27262017
146	STK38	0.26927986

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	5.51640199
2	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.92900437
3	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.88051943
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.52612962
5	Proteasome_Homo sapiens_hsa03050	2.49085624
6	ECM-receptor interaction_Homo sapiens_hsa04512	2.40476326
7	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.34610606
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.26542828
9	Sulfur metabolism_Homo sapiens_hsa00920	2.13677510
10	Protein digestion and absorption_Homo sapiens_hsa04974	2.12857246
11	Fatty acid elongation_Homo sapiens_hsa00062	2.11608501
12	Propanoate metabolism_Homo sapiens_hsa00640	2.05275990
13	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.03181832
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.95495177
15	Legionellosis_Homo sapiens_hsa05134	1.90289423
16	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.89083572
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83865669
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78281190
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.76395887
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.65358572
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46054909
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.45643636
23	Focal adhesion_Homo sapiens_hsa04510	1.44200318
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.42299688
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.42171845
26	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.40924800
27	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.40636480
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.40329461
29	Malaria_Homo sapiens_hsa05144	1.38744597
30	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.34431992
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.33759960
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.31909858
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.30039527
34	Carbon metabolism_Homo sapiens_hsa01200	1.28486296
35	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.26980228
36	Shigellosis_Homo sapiens_hsa05131	1.25975665
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.25399928
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.25046176
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.23001443
40	Parkinsons disease_Homo sapiens_hsa05012	1.20906113
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.17532012
42	Hippo signaling pathway_Homo sapiens_hsa04390	1.14902904
43	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.14478956
44	TNF signaling pathway_Homo sapiens_hsa04668	1.11845025
45	Adherens junction_Homo sapiens_hsa04520	1.11636232
46	p53 signaling pathway_Homo sapiens_hsa04115	1.10189095
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.09876541
48	Other glycan degradation_Homo sapiens_hsa00511	1.09086939
49	Phagosome_Homo sapiens_hsa04145	1.08584216
50	Ribosome_Homo sapiens_hsa03010	1.07690323
51	Small cell lung cancer_Homo sapiens_hsa05222	1.01982706
52	Antigen processing and presentation_Homo sapiens_hsa04612	1.01873129
53	Viral myocarditis_Homo sapiens_hsa05416	0.99511600
54	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.98118329
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97342480
56	Proteoglycans in cancer_Homo sapiens_hsa05205	0.96306665
57	Glutathione metabolism_Homo sapiens_hsa00480	0.94898458
58	Leishmaniasis_Homo sapiens_hsa05140	0.94215826
59	Huntingtons disease_Homo sapiens_hsa05016	0.93399848
60	RNA degradation_Homo sapiens_hsa03018	0.91357997
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.91246251
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.90348682
63	Peroxisome_Homo sapiens_hsa04146	0.90155366
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89250461
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88721899
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.88656469
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88600121
68	Prostate cancer_Homo sapiens_hsa05215	0.87407772
69	Butanoate metabolism_Homo sapiens_hsa00650	0.86904519
70	Cell cycle_Homo sapiens_hsa04110	0.86820277
71	Toxoplasmosis_Homo sapiens_hsa05145	0.86442027
72	Apoptosis_Homo sapiens_hsa04210	0.85767245
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.84853776
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84815055
75	Measles_Homo sapiens_hsa05162	0.84543143
76	Thyroid cancer_Homo sapiens_hsa05216	0.84162654
77	Bladder cancer_Homo sapiens_hsa05219	0.84048157
78	Folate biosynthesis_Homo sapiens_hsa00790	0.82980055
79	Hepatitis B_Homo sapiens_hsa05161	0.81440374
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.81408846
81	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.79996523
82	Pertussis_Homo sapiens_hsa05133	0.79614490
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79012862
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78252913
85	MicroRNAs in cancer_Homo sapiens_hsa05206	0.77957691
86	Spliceosome_Homo sapiens_hsa03040	0.77169665
87	Allograft rejection_Homo sapiens_hsa05330	0.75897865
88	Metabolic pathways_Homo sapiens_hsa01100	0.75184540
89	HTLV-I infection_Homo sapiens_hsa05166	0.74103309
90	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.73739149
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73602884
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.73057219
93	RNA polymerase_Homo sapiens_hsa03020	0.72991715
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72079664
95	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69725893
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69692144
97	Amoebiasis_Homo sapiens_hsa05146	0.68539957
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68057351
99	Mismatch repair_Homo sapiens_hsa03430	0.67709756
100	Galactose metabolism_Homo sapiens_hsa00052	0.67407220
101	Fat digestion and absorption_Homo sapiens_hsa04975	0.66933795
102	Influenza A_Homo sapiens_hsa05164	0.66729760
103	Regulation of autophagy_Homo sapiens_hsa04140	0.65199069
104	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65187408
105	Herpes simplex infection_Homo sapiens_hsa05168	0.65100289
106	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.64105392
107	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62373024
108	Base excision repair_Homo sapiens_hsa03410	0.61709022
109	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.61312043
110	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61185682
111	Alzheimers disease_Homo sapiens_hsa05010	0.60289298
112	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.59507261
113	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.59492571
114	Selenocompound metabolism_Homo sapiens_hsa00450	0.59037305
115	Renin-angiotensin system_Homo sapiens_hsa04614	0.58537148
116	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58185774
117	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57872444
118	Lysosome_Homo sapiens_hsa04142	0.57702090
119	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57430656
120	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.57374848
121	Viral carcinogenesis_Homo sapiens_hsa05203	0.57227160
122	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56947241
123	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56755807
124	Sphingolipid metabolism_Homo sapiens_hsa00600	0.55566629
125	RNA transport_Homo sapiens_hsa03013	0.55058918
126	Pancreatic cancer_Homo sapiens_hsa05212	0.53682423
127	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.53219346
128	Purine metabolism_Homo sapiens_hsa00230	0.51704378
129	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50989311
130	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50944709
131	Basal transcription factors_Homo sapiens_hsa03022	0.50419203
132	Fatty acid degradation_Homo sapiens_hsa00071	0.50192127
133	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.49823730
134	Pathways in cancer_Homo sapiens_hsa05200	0.49721741
135	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49320764
136	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.48813838
137	Pentose phosphate pathway_Homo sapiens_hsa00030	0.48677752
138	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.46433655
139	Graft-versus-host disease_Homo sapiens_hsa05332	0.46167502
140	Colorectal cancer_Homo sapiens_hsa05210	0.44913966
141	Hepatitis C_Homo sapiens_hsa05160	0.44793658
142	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43910549
143	mRNA surveillance pathway_Homo sapiens_hsa03015	0.43171303
144	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.43162004
145	Caffeine metabolism_Homo sapiens_hsa00232	0.42989262
146	Phototransduction_Homo sapiens_hsa04744	0.42168964
147	Melanoma_Homo sapiens_hsa05218	0.42023186
148	Oocyte meiosis_Homo sapiens_hsa04114	0.41863515
149	Mineral absorption_Homo sapiens_hsa04978	0.40284607
150	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.39702447
151	Tyrosine metabolism_Homo sapiens_hsa00350	0.39201190
152	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38835886
153	Nucleotide excision repair_Homo sapiens_hsa03420	0.38713132
154	Retinol metabolism_Homo sapiens_hsa00830	0.37832241
155	Salmonella infection_Homo sapiens_hsa05132	0.37363515
156	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37015288
157	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.36742692
158	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36606264
159	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36491191
160	One carbon pool by folate_Homo sapiens_hsa00670	0.36055964
161	Complement and coagulation cascades_Homo sapiens_hsa04610	0.35699471
162	Sulfur relay system_Homo sapiens_hsa04122	0.34157796

ARF4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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