ARF4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)5.75094019
2regulation of isotype switching to IgG isotypes (GO:0048302)5.50291905
3regulation of podosome assembly (GO:0071801)5.41912060
4positive regulation of chemokine biosynthetic process (GO:0045080)5.06964363
5regulation of chronic inflammatory response (GO:0002676)4.78934681
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71238912
7regulation of MHC class II biosynthetic process (GO:0045346)4.51681400
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.50435962
9protein neddylation (GO:0045116)4.37170105
10proteasome assembly (GO:0043248)4.29106304
11DNA deamination (GO:0045006)4.16357036
12regulation of immunoglobulin secretion (GO:0051023)4.11358093
13L-fucose catabolic process (GO:0042355)4.08154853
14fucose catabolic process (GO:0019317)4.08154853
15L-fucose metabolic process (GO:0042354)4.08154853
16sequestering of actin monomers (GO:0042989)3.93143990
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85873164
18ATP synthesis coupled proton transport (GO:0015986)3.85873164
19regulation of chemokine biosynthetic process (GO:0045073)3.81399870
20fucose metabolic process (GO:0006004)3.76932820
21protein polyglutamylation (GO:0018095)3.69359235
22cell wall macromolecule catabolic process (GO:0016998)3.68124163
23negative regulation of neurological system process (GO:0031645)3.64244440
24alpha-beta T cell differentiation involved in immune response (GO:0002293)3.61485723
25alpha-beta T cell activation involved in immune response (GO:0002287)3.61485723
26T cell differentiation involved in immune response (GO:0002292)3.61485723
27positive regulation of DNA recombination (GO:0045911)3.56688089
28fucosylation (GO:0036065)3.56632112
29protein complex biogenesis (GO:0070271)3.55426814
30positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.49833275
31negative regulation of T-helper cell differentiation (GO:0045623)3.49189142
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.49189142
33positive regulation of isotype switching (GO:0045830)3.47437076
34negative regulation of acute inflammatory response (GO:0002674)3.44090570
35cullin deneddylation (GO:0010388)3.41779464
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40654079
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.37278445
38NADH dehydrogenase complex assembly (GO:0010257)3.37278445
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37278445
40chaperone-mediated protein transport (GO:0072321)3.28780994
41neuron fate determination (GO:0048664)3.27948902
42intracellular protein transmembrane import (GO:0044743)3.27179959
43outer ear morphogenesis (GO:0042473)3.26042203
44protein deneddylation (GO:0000338)3.25747440
45aldehyde catabolic process (GO:0046185)3.25565860
46cellular ketone body metabolic process (GO:0046950)3.19952642
47regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.14610457
48mitochondrial respiratory chain complex assembly (GO:0033108)3.10600069
49water-soluble vitamin biosynthetic process (GO:0042364)3.09090010
50inner mitochondrial membrane organization (GO:0007007)3.08351182
51cell wall macromolecule metabolic process (GO:0044036)3.05837152
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04271805
53regulation of proton transport (GO:0010155)3.03988433
54signal peptide processing (GO:0006465)3.02447433
55regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.02435022
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01268228
57termination of RNA polymerase III transcription (GO:0006386)3.00926333
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.00926333
59secretory granule organization (GO:0033363)2.97649769
60regulation of cilium movement (GO:0003352)2.93803084
61cellular response to nicotine (GO:0071316)2.89124424
62positive regulation of transcription regulatory region DNA binding (GO:2000679)2.88816094
63regulation of vitamin D biosynthetic process (GO:0060556)2.88263268
64mitotic cell cycle arrest (GO:0071850)2.84130068
65ketone body metabolic process (GO:1902224)2.82488189
66axoneme assembly (GO:0035082)2.81570051
67positive regulation of immunoglobulin production (GO:0002639)2.80457350
68mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.80042718
69synapsis (GO:0007129)2.79265240
70negative regulation of alpha-beta T cell differentiation (GO:0046639)2.78846324
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.77442470
72CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.75065853
73T-helper cell differentiation (GO:0042093)2.75065853
74regulation of mitotic spindle checkpoint (GO:1903504)2.74282946
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74282946
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72303669
77isotype switching (GO:0045190)2.72303669
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72303669
79auditory receptor cell stereocilium organization (GO:0060088)2.64289104
80prenylation (GO:0097354)2.63994411
81protein prenylation (GO:0018342)2.63994411
82GTP biosynthetic process (GO:0006183)2.62651101
83anterograde synaptic vesicle transport (GO:0048490)2.61628287
84negative regulation of oligodendrocyte differentiation (GO:0048715)2.59716836
85regulation of feeding behavior (GO:0060259)2.59661926
86proline transport (GO:0015824)2.58645137
87respiratory electron transport chain (GO:0022904)2.58540483
88organelle disassembly (GO:1903008)2.57469010
89type B pancreatic cell proliferation (GO:0044342)2.57466158
90inositol phosphate-mediated signaling (GO:0048016)2.56518423
91positive regulation of organelle assembly (GO:1902117)2.55470428
92electron transport chain (GO:0022900)2.55157402
93lactate metabolic process (GO:0006089)2.51994395
94nephron epithelium morphogenesis (GO:0072088)2.51329240
95nephron tubule morphogenesis (GO:0072078)2.51329240
96negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.51105050
97positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.51060511
98regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.51060511
99defense response to protozoan (GO:0042832)2.51054705
100kinetochore assembly (GO:0051382)2.50407633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98647739
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.65935294
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.42769707
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.98982765
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.86959988
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66585141
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.64023468
8ELK1_19687146_ChIP-ChIP_HELA_Human2.54488450
9EWS_26573619_Chip-Seq_HEK293_Human2.49100606
10ZNF274_21170338_ChIP-Seq_K562_Hela2.40959197
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32387319
12IGF1R_20145208_ChIP-Seq_DFB_Human2.29391613
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.23672303
14VDR_22108803_ChIP-Seq_LS180_Human2.18963653
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17217706
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13816265
17VDR_23849224_ChIP-Seq_CD4+_Human2.12140592
18FUS_26573619_Chip-Seq_HEK293_Human2.09899109
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09369270
20TAF15_26573619_Chip-Seq_HEK293_Human2.08730489
21P300_19829295_ChIP-Seq_ESCs_Human2.08245962
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05193204
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98378538
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77669013
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.77542815
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74504409
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.71217551
28FOXP3_21729870_ChIP-Seq_TREG_Human1.68663524
29TP53_22573176_ChIP-Seq_HFKS_Human1.65123933
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64742843
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64295972
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.63593119
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.63388574
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60278658
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55146906
36GBX2_23144817_ChIP-Seq_PC3_Human1.54958609
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51232964
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49893181
39MYC_18940864_ChIP-ChIP_HL60_Human1.49503144
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49154025
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48386294
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47844264
43BCAT_22108803_ChIP-Seq_LS180_Human1.46613923
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45291458
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45013528
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43937264
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40320614
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40171424
49P53_22387025_ChIP-Seq_ESCs_Mouse1.39392122
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.38909564
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33212939
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32263986
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29163227
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.28969930
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.28264777
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26647652
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25854432
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25457277
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24879328
60CBP_20019798_ChIP-Seq_JUKART_Human1.24879328
61SOX2_19829295_ChIP-Seq_ESCs_Human1.24201172
62NANOG_19829295_ChIP-Seq_ESCs_Human1.24201172
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.23345201
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23155052
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21655584
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19187704
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18895046
68IRF1_19129219_ChIP-ChIP_H3396_Human1.17800833
69TCF4_22108803_ChIP-Seq_LS180_Human1.15895122
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15161518
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14784154
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13244785
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11607946
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.11607946
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11473477
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.09371958
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.09127325
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08567557
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.08562606
80CDX2_22108803_ChIP-Seq_LS180_Human1.08243278
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08144625
82TP53_18474530_ChIP-ChIP_U2OS_Human1.07404702
83ER_23166858_ChIP-Seq_MCF-7_Human1.06901268
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06318366
85P300_18555785_Chip-Seq_ESCs_Mouse1.05979639
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.05100599
87AR_20517297_ChIP-Seq_VCAP_Human1.04861913
88JUN_21703547_ChIP-Seq_K562_Human1.04676777
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04068091
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02586884
91DCP1A_22483619_ChIP-Seq_HELA_Human1.01735613
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.00975515
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.00345072
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00206135
95AR_25329375_ChIP-Seq_VCAP_Human0.99329121
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99234416
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98403957
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98398698
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.98325125
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98021848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.81261509
2MP0008875_abnormal_xenobiotic_pharmacok4.05702560
3MP0001348_abnormal_lacrimal_gland3.68890852
4MP0006082_CNS_inflammation3.36350082
5MP0002837_dystrophic_cardiac_calcinosis2.95423537
6MP0006072_abnormal_retinal_apoptosis2.93658232
7MP0009697_abnormal_copulation2.64459777
8MP0001835_abnormal_antigen_presentation2.54733747
9MP0001984_abnormal_olfaction2.32751254
10MP0003195_calcinosis2.32477898
11MP0006054_spinal_hemorrhage2.28285130
12MP0001986_abnormal_taste_sensitivity2.18073620
13MP0004142_abnormal_muscle_tone2.17085505
14MP0008877_abnormal_DNA_methylation2.15246491
15MP0005310_abnormal_salivary_gland2.14765213
16MP0009046_muscle_twitch2.08540457
17MP0003122_maternal_imprinting2.06261950
18MP0008872_abnormal_physiological_respon2.01378491
19MP0005671_abnormal_response_to1.99936181
20MP0002254_reproductive_system_inflammat1.99493945
21MP0005645_abnormal_hypothalamus_physiol1.98784934
22MP0003186_abnormal_redox_activity1.95237502
23MP0005551_abnormal_eye_electrophysiolog1.93421807
24MP0001905_abnormal_dopamine_level1.79684937
25MP0005253_abnormal_eye_physiology1.78357458
26MP0004782_abnormal_surfactant_physiolog1.75521354
27MP0005367_renal/urinary_system_phenotyp1.74264455
28MP0000516_abnormal_urinary_system1.74264455
29MP0002876_abnormal_thyroid_physiology1.71421854
30MP0002822_catalepsy1.58227805
31MP0005387_immune_system_phenotype1.44732107
32MP0001790_abnormal_immune_system1.44732107
33MP0003787_abnormal_imprinting1.40572701
34MP0009384_cardiac_valve_regurgitation1.35107137
35MP0004043_abnormal_pH_regulation1.34669579
36MP0001968_abnormal_touch/_nociception1.29338006
37MP0001502_abnormal_circadian_rhythm1.27890264
38MP0009745_abnormal_behavioral_response1.26628897
39MP0002272_abnormal_nervous_system1.24008918
40MP0002693_abnormal_pancreas_physiology1.22848166
41MP0002163_abnormal_gland_morphology1.20878923
42MP0009333_abnormal_splenocyte_physiolog1.14984854
43MP0005075_abnormal_melanosome_morpholog1.11534814
44MP0003718_maternal_effect1.11218875
45MP0003937_abnormal_limbs/digits/tail_de1.04018596
46MP0009379_abnormal_foot_pigmentation1.03538950
47MP0002009_preneoplasia1.02375635
48MP0001501_abnormal_sleep_pattern1.01964717
49MP0004215_abnormal_myocardial_fiber1.00892491
50MP0003137_abnormal_impulse_conducting1.00189157
51MP0000049_abnormal_middle_ear0.98284554
52MP0004885_abnormal_endolymph0.98135917
53MP0005379_endocrine/exocrine_gland_phen0.97295828
54MP0005410_abnormal_fertilization0.96954854
55MP0005084_abnormal_gallbladder_morpholo0.94228911
56MP0005187_abnormal_penis_morphology0.94224330
57MP0002736_abnormal_nociception_after0.94073148
58MP0001485_abnormal_pinna_reflex0.93942772
59MP0005167_abnormal_blood-brain_barrier0.92089601
60MP0002653_abnormal_ependyma_morphology0.91254925
61MP0005085_abnormal_gallbladder_physiolo0.87146448
62MP0003880_abnormal_central_pattern0.85925977
63MP0004145_abnormal_muscle_electrophysio0.85471722
64MP0002148_abnormal_hypersensitivity_rea0.85306528
65MP0009764_decreased_sensitivity_to0.85058442
66MP0001188_hyperpigmentation0.83570613
67MP0010386_abnormal_urinary_bladder0.82085539
68MP0005395_other_phenotype0.81375332
69MP0001529_abnormal_vocalization0.80500771
70MP0002751_abnormal_autonomic_nervous0.80069760
71MP0005319_abnormal_enzyme/_coenzyme0.79973687
72MP0006276_abnormal_autonomic_nervous0.79889866
73MP0005000_abnormal_immune_tolerance0.79748625
74MP0002006_tumorigenesis0.78539059
75MP0003011_delayed_dark_adaptation0.76424838
76MP0002168_other_aberrant_phenotype0.75505430
77MP0006292_abnormal_olfactory_placode0.75421213
78MP0002166_altered_tumor_susceptibility0.74165004
79MP0004084_abnormal_cardiac_muscle0.73743666
80MP0005646_abnormal_pituitary_gland0.72952961
81MP0000013_abnormal_adipose_tissue0.72370763
82MP0005174_abnormal_tail_pigmentation0.72191470
83MP0005332_abnormal_amino_acid0.71329844
84MP0001881_abnormal_mammary_gland0.71035036
85MP0001663_abnormal_digestive_system0.70885931
86MP0004924_abnormal_behavior0.70551393
87MP0005386_behavior/neurological_phenoty0.70551393
88MP0000569_abnormal_digit_pigmentation0.70427270
89MP0003121_genomic_imprinting0.68558839
90MP0003252_abnormal_bile_duct0.68515465
91MP0004883_abnormal_blood_vessel0.67528942
92MP0008873_increased_physiological_sensi0.65812993
93MP0005408_hypopigmentation0.65798584
94MP0003646_muscle_fatigue0.65534250
95MP0002277_abnormal_respiratory_mucosa0.62807376
96MP0002733_abnormal_thermal_nociception0.62017168
97MP0000427_abnormal_hair_cycle0.61642270
98MP0000015_abnormal_ear_pigmentation0.61641999
99MP0002102_abnormal_ear_morphology0.61572221
100MP0008007_abnormal_cellular_replicative0.61339389

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.28910892
2Abnormality of midbrain morphology (HP:0002418)4.12301405
3Molar tooth sign on MRI (HP:0002419)4.12301405
4True hermaphroditism (HP:0010459)3.89909782
5Pancreatic fibrosis (HP:0100732)3.82760009
6Colon cancer (HP:0003003)3.59848122
7Abnormal rod and cone electroretinograms (HP:0008323)3.30182325
8Hypoproteinemia (HP:0003075)3.27054782
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19637237
10Abnormality of alanine metabolism (HP:0010916)3.19637237
11Hyperalaninemia (HP:0003348)3.19637237
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.07044023
13Medial flaring of the eyebrow (HP:0010747)3.06631157
14Lipid accumulation in hepatocytes (HP:0006561)2.95529474
15Nephronophthisis (HP:0000090)2.94659039
16Congenital stationary night blindness (HP:0007642)2.90477354
17Large for gestational age (HP:0001520)2.80486681
18Acute encephalopathy (HP:0006846)2.79208512
19Decreased central vision (HP:0007663)2.77419042
20Renal cortical cysts (HP:0000803)2.74649571
21Cystic liver disease (HP:0006706)2.70678031
22Limb dystonia (HP:0002451)2.68250959
23Sclerocornea (HP:0000647)2.66860236
24Abnormality of the renal cortex (HP:0011035)2.64517341
25Increased hepatocellular lipid droplets (HP:0006565)2.62057538
26Acute necrotizing encephalopathy (HP:0006965)2.58563681
27Mitochondrial inheritance (HP:0001427)2.53461330
28Hypothermia (HP:0002045)2.53387447
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.43346789
30Congenital primary aphakia (HP:0007707)2.38962618
31Attenuation of retinal blood vessels (HP:0007843)2.37799046
32Hypoalbuminemia (HP:0003073)2.37217366
33Abnormal albumin level (HP:0012116)2.37217366
34Abnormality of the renal medulla (HP:0100957)2.35909272
35Increased CSF lactate (HP:0002490)2.35708615
36Hemiparesis (HP:0001269)2.34566482
37Constricted visual fields (HP:0001133)2.34356537
38Type I transferrin isoform profile (HP:0003642)2.31352072
39Gait imbalance (HP:0002141)2.30927747
40Opisthotonus (HP:0002179)2.30925869
41Nephrogenic diabetes insipidus (HP:0009806)2.30802912
42Furrowed tongue (HP:0000221)2.29671163
43Hepatic necrosis (HP:0002605)2.26778917
44Abnormality of macular pigmentation (HP:0008002)2.26719013
45Abnormal sex determination (HP:0012244)2.25481007
46Sex reversal (HP:0012245)2.25481007
47Intestinal atresia (HP:0011100)2.21902945
48Palpitations (HP:0001962)2.21481357
49Abnormal biliary tract physiology (HP:0012439)2.21162750
50Bile duct proliferation (HP:0001408)2.21162750
51Abnormal mitochondria in muscle tissue (HP:0008316)2.18483182
52Progressive macrocephaly (HP:0004481)2.17285927
53Hemiplegia (HP:0002301)2.16067785
54Male pseudohermaphroditism (HP:0000037)2.14132022
55Type II lissencephaly (HP:0007260)2.12415459
56Hepatocellular necrosis (HP:0001404)2.10391292
573-Methylglutaconic aciduria (HP:0003535)2.07874446
58Posterior subcapsular cataract (HP:0007787)2.06508669
59Abnormal glycosylation (HP:0012345)2.06080404
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06080404
61Abnormal protein N-linked glycosylation (HP:0012347)2.06080404
62Abnormal protein glycosylation (HP:0012346)2.06080404
63Tachypnea (HP:0002789)2.04000353
64Optic disc pallor (HP:0000543)2.01576752
65Hypoplasia of the fovea (HP:0007750)2.01423339
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.01423339
67Postural tremor (HP:0002174)1.99709354
68Abolished electroretinogram (ERG) (HP:0000550)1.98129232
69Abnormality of renal resorption (HP:0011038)1.95723376
70Stomatitis (HP:0010280)1.92737950
71Hyperglycinuria (HP:0003108)1.92596393
72Renal Fanconi syndrome (HP:0001994)1.91199797
73Cerebral edema (HP:0002181)1.90334181
74Postaxial hand polydactyly (HP:0001162)1.89763542
75Delayed CNS myelination (HP:0002188)1.88544309
76Retinal dysplasia (HP:0007973)1.88458789
77Hypoglycemic coma (HP:0001325)1.88206847
78Pendular nystagmus (HP:0012043)1.87597766
79Lethargy (HP:0001254)1.87024785
80Cerebral hypomyelination (HP:0006808)1.86382904
81Congenital hepatic fibrosis (HP:0002612)1.86270715
82Increased intramyocellular lipid droplets (HP:0012240)1.86021549
83Delayed gross motor development (HP:0002194)1.85815006
84Narrow forehead (HP:0000341)1.84820022
85Increased serum lactate (HP:0002151)1.84797330
86Adactyly (HP:0009776)1.84605653
87Anencephaly (HP:0002323)1.83730009
88Optic nerve coloboma (HP:0000588)1.81923458
89Pancreatic islet-cell hyperplasia (HP:0004510)1.81317175
90Increased muscle lipid content (HP:0009058)1.79509673
91Fibular aplasia (HP:0002990)1.79297100
92Hyperglycinemia (HP:0002154)1.78852419
93Short tibia (HP:0005736)1.78492964
94Hypokinesia (HP:0002375)1.78084932
95Keratoconus (HP:0000563)1.77669259
96Increased corneal curvature (HP:0100692)1.77669259
97Abnormality of the fovea (HP:0000493)1.75162187
98Postaxial foot polydactyly (HP:0001830)1.74315617
99Cupped ear (HP:0000378)1.73108118
100Preaxial hand polydactyly (HP:0001177)1.72711509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.32565016
2EIF2AK33.27412995
3SRPK13.25694541
4PIM22.78916668
5TXK2.75360554
6MAP4K22.63093628
7BCR2.59433583
8TSSK62.58617134
9FRK2.24835740
10TRIM282.24668397
11EIF2AK11.97218748
12NME11.92086379
13CSNK1G31.89704433
14NUAK11.88098354
15ARAF1.81677861
16ERBB31.78150067
17PAK31.74450020
18WNK41.67493178
19CSNK1G21.60449028
20ADRBK21.54741012
21MAP3K41.49793129
22EIF2AK21.45549000
23BMPR21.44926808
24PBK1.44652883
25CSNK1A1L1.43028499
26CSNK1G11.42004438
27MUSK1.40184355
28WNK31.39155034
29GRK11.38136213
30TIE11.36855726
31VRK11.33384170
32MAP2K71.27385408
33EPHA31.27245466
34PLK21.25954500
35SIK31.24849445
36PTK2B1.21104737
37MAPK131.15370837
38PLK31.14191486
39WEE11.11098646
40BUB11.10737835
41BCKDK1.09463423
42STK38L1.08946786
43MAP2K61.05488002
44KDR1.04029351
45MST41.03390257
46ITK0.99773951
47GRK70.93895721
48STK240.92903580
49STK390.91503377
50ZAK0.88896702
51PRKCE0.85720089
52INSRR0.80928963
53TNIK0.80612232
54BRAF0.79823892
55ADRBK10.74059815
56MYLK0.73670486
57MAP3K120.72944119
58STK40.72598446
59BMPR1B0.72445695
60PRKG10.68197548
61GRK50.66591078
62TEC0.61267256
63PKN10.59324685
64CSNK1A10.59055234
65STK160.58402730
66TAF10.54214962
67IKBKB0.51834049
68UHMK10.50493833
69AKT30.50375209
70STK30.50076020
71CAMK2A0.45778670
72WNK10.45718883
73NEK10.45039681
74MKNK10.44545212
75CAMK2D0.42580760
76PRKCQ0.42381390
77DAPK30.41822189
78PRKG20.40388792
79CAMK2G0.39715918
80MINK10.39690825
81RPS6KA50.38466340
82MARK10.36675124
83DYRK20.36491844
84PAK10.36100112
85PHKG10.35944827
86PHKG20.35944827
87PRKACA0.35148035
88YES10.34121370
89PRKCG0.33675086
90OXSR10.33187508
91CSNK1D0.32689053
92PIM10.32569500
93CSNK2A10.31195503
94PINK10.29660097
95PRKACG0.29593052
96KIT0.29450891
97DAPK20.27958073
98FGFR10.27682931
99ROCK20.27440896
100PLK40.26832048

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.77288803
2Proteasome_Homo sapiens_hsa030503.53448585
3Oxidative phosphorylation_Homo sapiens_hsa001903.26214919
4Sulfur metabolism_Homo sapiens_hsa009203.21790522
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74036360
6Parkinsons disease_Homo sapiens_hsa050122.56312189
7Propanoate metabolism_Homo sapiens_hsa006402.53398826
8Allograft rejection_Homo sapiens_hsa053302.35624682
9RNA polymerase_Homo sapiens_hsa030202.31131063
10Asthma_Homo sapiens_hsa053101.97453332
11Autoimmune thyroid disease_Homo sapiens_hsa053201.94982919
12Basal transcription factors_Homo sapiens_hsa030221.93252331
13Alzheimers disease_Homo sapiens_hsa050101.71834493
14Huntingtons disease_Homo sapiens_hsa050161.70576134
15Fatty acid elongation_Homo sapiens_hsa000621.69794275
16Butanoate metabolism_Homo sapiens_hsa006501.69516092
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69285960
18Nitrogen metabolism_Homo sapiens_hsa009101.64375952
19Regulation of autophagy_Homo sapiens_hsa041401.62231125
20Caffeine metabolism_Homo sapiens_hsa002321.59355449
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.58076613
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57944046
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42324735
24Phototransduction_Homo sapiens_hsa047441.36946092
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33632739
26Nucleotide excision repair_Homo sapiens_hsa034201.32758116
27Type I diabetes mellitus_Homo sapiens_hsa049401.28935961
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25008731
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23797231
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19722329
31Tryptophan metabolism_Homo sapiens_hsa003801.16851900
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.15873665
33Non-homologous end-joining_Homo sapiens_hsa034501.15303624
34T cell receptor signaling pathway_Homo sapiens_hsa046601.13006529
35Collecting duct acid secretion_Homo sapiens_hsa049661.12634931
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08081859
37Purine metabolism_Homo sapiens_hsa002301.07655576
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05944030
39Pyrimidine metabolism_Homo sapiens_hsa002400.99422233
40Rheumatoid arthritis_Homo sapiens_hsa053230.98770858
41Graft-versus-host disease_Homo sapiens_hsa053320.98145407
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97482118
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96686605
44Cardiac muscle contraction_Homo sapiens_hsa042600.95013525
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93795112
46Peroxisome_Homo sapiens_hsa041460.93622494
47Steroid biosynthesis_Homo sapiens_hsa001000.90475708
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86670432
49African trypanosomiasis_Homo sapiens_hsa051430.85824179
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84911564
51Fatty acid metabolism_Homo sapiens_hsa012120.84520826
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84341566
53One carbon pool by folate_Homo sapiens_hsa006700.79174252
54Sulfur relay system_Homo sapiens_hsa041220.75970246
55ABC transporters_Homo sapiens_hsa020100.74231334
56beta-Alanine metabolism_Homo sapiens_hsa004100.74196788
57Chemical carcinogenesis_Homo sapiens_hsa052040.73425592
58Primary immunodeficiency_Homo sapiens_hsa053400.71713714
59Linoleic acid metabolism_Homo sapiens_hsa005910.71319913
60RNA transport_Homo sapiens_hsa030130.71047275
61Salmonella infection_Homo sapiens_hsa051320.70562559
62Folate biosynthesis_Homo sapiens_hsa007900.69371747
63Pyruvate metabolism_Homo sapiens_hsa006200.68919935
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66934050
65RNA degradation_Homo sapiens_hsa030180.66644524
66Hematopoietic cell lineage_Homo sapiens_hsa046400.64439993
67Mismatch repair_Homo sapiens_hsa034300.63562380
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63482317
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.63054537
70p53 signaling pathway_Homo sapiens_hsa041150.60760944
71Fatty acid degradation_Homo sapiens_hsa000710.58531492
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57760680
73Insulin secretion_Homo sapiens_hsa049110.57011078
74Metabolic pathways_Homo sapiens_hsa011000.56236996
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53728679
76Retinol metabolism_Homo sapiens_hsa008300.52903830
77Homologous recombination_Homo sapiens_hsa034400.51710891
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48756731
79Vitamin B6 metabolism_Homo sapiens_hsa007500.45425106
80Circadian entrainment_Homo sapiens_hsa047130.45416298
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43466506
82Antigen processing and presentation_Homo sapiens_hsa046120.42485454
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42406696
84Morphine addiction_Homo sapiens_hsa050320.41832540
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41642463
86Renin secretion_Homo sapiens_hsa049240.40998448
87Glutathione metabolism_Homo sapiens_hsa004800.40531044
88Dopaminergic synapse_Homo sapiens_hsa047280.39349452
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38317973
90Fanconi anemia pathway_Homo sapiens_hsa034600.38059435
91GABAergic synapse_Homo sapiens_hsa047270.37010297
92Selenocompound metabolism_Homo sapiens_hsa004500.35794112
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35625045
94Vibrio cholerae infection_Homo sapiens_hsa051100.33899177
95Spliceosome_Homo sapiens_hsa030400.33755180
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32326893
97Arginine and proline metabolism_Homo sapiens_hsa003300.32103327
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29954907
99Olfactory transduction_Homo sapiens_hsa047400.29472022
100Salivary secretion_Homo sapiens_hsa049700.29267914

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