ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phospholipid efflux (GO:0033700)	9.95831683
2	regulation of triglyceride catabolic process (GO:0010896)	9.55105197
3	reverse cholesterol transport (GO:0043691)	8.56893891
4	plasma lipoprotein particle assembly (GO:0034377)	8.22118177
5	very-low-density lipoprotein particle assembly (GO:0034379)	7.47557982
6	regulation of cholesterol esterification (GO:0010872)	7.34217503
7	protein-lipid complex assembly (GO:0065005)	7.20789442
8	cholesterol efflux (GO:0033344)	7.10388269
9	protein-lipid complex remodeling (GO:0034368)	6.15916030
10	macromolecular complex remodeling (GO:0034367)	6.15916030
11	plasma lipoprotein particle remodeling (GO:0034369)	6.15916030
12	negative regulation of lipase activity (GO:0060192)	6.10433422
13	negative regulation of fatty acid biosynthetic process (GO:0045717)	5.98938044
14	polyol transport (GO:0015791)	5.28703865
15	negative regulation of cholesterol transport (GO:0032375)	5.22824880
16	negative regulation of sterol transport (GO:0032372)	5.22824880
17	regulation of lipoprotein metabolic process (GO:0050746)	5.10880276
18	lipoprotein transport (GO:0042953)	5.08424252
19	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.01540691
20	cellular response to zinc ion (GO:0071294)	4.66541304
21	plasma lipoprotein particle organization (GO:0071827)	4.57537940
22	plasma lipoprotein particle clearance (GO:0034381)	4.56409773
23	acrosome reaction (GO:0007340)	4.53810176
24	response to pheromone (GO:0019236)	4.46329283
25	transepithelial transport (GO:0070633)	4.43622086
26	ovulation from ovarian follicle (GO:0001542)	4.32968186
27	protein-lipid complex subunit organization (GO:0071825)	4.24363493
28	triglyceride homeostasis (GO:0070328)	4.18924117
29	acylglycerol homeostasis (GO:0055090)	4.18924117
30	positive regulation of lipoprotein lipase activity (GO:0051006)	4.05857857
31	positive regulation of triglyceride lipase activity (GO:0061365)	4.05857857
32	regulation of triglyceride metabolic process (GO:0090207)	4.02782113
33	regulation of lipoprotein particle clearance (GO:0010984)	3.90418244
34	positive regulation of steroid metabolic process (GO:0045940)	3.78682453
35	positive regulation of insulin receptor signaling pathway (GO:0046628)	3.72121711
36	negative regulation of lipid catabolic process (GO:0050995)	3.68142914
37	cholesterol transport (GO:0030301)	3.67562906
38	sterol transport (GO:0015918)	3.67562906
39	protein carboxylation (GO:0018214)	3.66177912
40	peptidyl-glutamic acid carboxylation (GO:0017187)	3.66177912
41	chemosensory behavior (GO:0007635)	3.60154241
42	regulation of fatty acid biosynthetic process (GO:0042304)	3.49785488
43	negative regulation of gluconeogenesis (GO:0045721)	3.46863713
44	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.44733321
45	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.44733321
46	multicellular organism reproduction (GO:0032504)	3.35886343
47	positive regulation of histone H3-K4 methylation (GO:0051571)	3.31309410
48	serotonin receptor signaling pathway (GO:0007210)	3.27340894
49	removal of superoxide radicals (GO:0019430)	3.24716085
50	cellular response to superoxide (GO:0071451)	3.24716085
51	cellular response to oxygen radical (GO:0071450)	3.24716085
52	regulation of sterol transport (GO:0032371)	3.23945641
53	regulation of cholesterol transport (GO:0032374)	3.23945641
54	regulation of lipoprotein lipase activity (GO:0051004)	3.23825410
55	response to hydroperoxide (GO:0033194)	3.20908312
56	negative regulation of receptor-mediated endocytosis (GO:0048261)	3.19550184
57	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.18876260
58	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.15942862
59	lipoprotein metabolic process (GO:0042157)	3.15699863
60	acylglycerol catabolic process (GO:0046464)	3.14799283
61	neutral lipid catabolic process (GO:0046461)	3.14799283
62	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.14182005
63	positive regulation of triglyceride metabolic process (GO:0090208)	3.13298594
64	synapsis (GO:0007129)	3.12659628
65	sphingoid metabolic process (GO:0046519)	3.10968499
66	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.08568004
67	sperm capacitation (GO:0048240)	3.07142000
68	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.07117847
69	cholesterol homeostasis (GO:0042632)	3.05403953
70	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	3.04425902
71	regulation of MHC class II biosynthetic process (GO:0045346)	3.04361758
72	water-soluble vitamin biosynthetic process (GO:0042364)	3.03605453
73	negative regulation of fatty acid metabolic process (GO:0045922)	3.03073461
74	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.99951356
75	glial cell proliferation (GO:0014009)	2.98041936
76	sterol homeostasis (GO:0055092)	2.96940560
77	triglyceride catabolic process (GO:0019433)	2.91134272
78	negative regulation of metanephros development (GO:0072217)	2.85753924
79	response to phenylpropanoid (GO:0080184)	2.84178156
80	regulation of clathrin-mediated endocytosis (GO:2000369)	2.83397154
81	mannosylation (GO:0097502)	2.82739715
82	regulation of cytokine secretion involved in immune response (GO:0002739)	2.79770554
83	phototransduction, visible light (GO:0007603)	2.79715225
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79557226
85	phosphatidylethanolamine metabolic process (GO:0046337)	2.77923157
86	progesterone metabolic process (GO:0042448)	2.75272831
87	phagocytosis, recognition (GO:0006910)	2.75159861
88	sphingosine metabolic process (GO:0006670)	2.75052571
89	positive regulation of vesicle fusion (GO:0031340)	2.74480192
90	piRNA metabolic process (GO:0034587)	2.71651443
91	centriole replication (GO:0007099)	2.69081531
92	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	2.67665058
93	positive regulation of lipid catabolic process (GO:0050996)	2.67559527
94	one-carbon compound transport (GO:0019755)	2.64246368
95	intra-S DNA damage checkpoint (GO:0031573)	2.61519141
96	response to superoxide (GO:0000303)	2.61307274
97	response to oxygen radical (GO:0000305)	2.60268017
98	peptide biosynthetic process (GO:0043043)	2.59573302
99	detection of visible light (GO:0009584)	2.59139387
100	high-density lipoprotein particle remodeling (GO:0034375)	10.2070942

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.52092191
2	VDR_22108803_ChIP-Seq_LS180_Human	3.39143820
3	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.94063003
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.71910356
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.56217215
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.48222178
7	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.37314597
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.26925454
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24779677
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19155644
11	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.12277558
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.11366659
13	GATA1_22025678_ChIP-Seq_K562_Human	2.10302728
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.02945052
15	FOXA1_27270436_Chip-Seq_PROSTATE_Human	2.02611284
16	FOXA1_25329375_ChIP-Seq_VCAP_Human	2.02611284
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.99525018
18	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.86356720
19	CBP_20019798_ChIP-Seq_JUKART_Human	1.85887899
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.85887899
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85441422
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84226799
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.83643765
24	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.83195568
25	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.78779159
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77211441
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70214934
28	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.68532875
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67722050
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61846400
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60150815
32	FUS_26573619_Chip-Seq_HEK293_Human	1.57721727
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56984709
34	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.55934659
35	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.49894608
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.49812773
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49413060
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46909350
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.44587536
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44060665
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40479469
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38773924
43	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.38542593
44	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37954603
45	P300_19829295_ChIP-Seq_ESCs_Human	1.37750428
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36709142
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.35353317
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35110480
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32801233
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32171540
51	AR_20517297_ChIP-Seq_VCAP_Human	1.28171357
52	CEBPB_22108803_ChIP-Seq_LS180_Human	1.27688707
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.26724294
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26140292
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23874488
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23874488
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22903081
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22737990
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.20393194
60	NCOR_22424771_ChIP-Seq_293T_Human	1.20192497
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.19986081
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19757991
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.17583293
64	AR_25329375_ChIP-Seq_VCAP_Human	1.16959556
65	GATA3_26560356_Chip-Seq_TH1_Human	1.16756867
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.16523013
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16129554
68	STAT3_23295773_ChIP-Seq_U87_Human	1.16094438
69	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.14394451
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.13079764
71	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.12395144
72	OCT4_20526341_ChIP-Seq_ESCs_Human	1.10847697
73	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10773197
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.10521056
75	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.10231894
76	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.10151026
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08914604
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08879353
79	SMRT_27268052_Chip-Seq_Bcells_Human	1.08025094
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06432845
81	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06147510
82	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.05873476
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03206581
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02753186
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01388309
86	TCF4_23295773_ChIP-Seq_U87_Human	1.00947088
87	GATA3_26560356_Chip-Seq_TH2_Human	1.00869737
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.00166299
89	CBP_21632823_ChIP-Seq_H3396_Human	0.99866285
90	EWS_26573619_Chip-Seq_HEK293_Human	0.98201633
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97555437
92	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.97262613
93	FOXP3_21729870_ChIP-Seq_TREG_Human	0.97191787
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96686625
95	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.96605545
96	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94123044
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94044912
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93960784
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.93627673
100	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93350752

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.42582056
2	MP0006054_spinal_hemorrhage	4.04227730
3	MP0001873_stomach_inflammation	3.14401024
4	MP0001835_abnormal_antigen_presentation	3.10146005
5	MP0010329_abnormal_lipoprotein_level	2.41199884
6	MP0004147_increased_porphyrin_level	2.33650426
7	MP0003186_abnormal_redox_activity	2.32662249
8	MP0000372_irregular_coat_pigmentation	2.29957357
9	MP0004270_analgesia	2.28266237
10	MP0003878_abnormal_ear_physiology	2.25012092
11	MP0005377_hearing/vestibular/ear_phenot	2.25012092
12	MP0002876_abnormal_thyroid_physiology	2.24405540
13	MP0005551_abnormal_eye_electrophysiolog	2.12524726
14	MP0008875_abnormal_xenobiotic_pharmacok	2.10107911
15	MP0003567_abnormal_fetal_cardiomyocyte	2.07917711
16	MP0002163_abnormal_gland_morphology	2.03224452
17	MP0001958_emphysema	2.01925618
18	MP0009840_abnormal_foam_cell	10.6099485
19	MP0006072_abnormal_retinal_apoptosis	1.91270099
20	MP0004019_abnormal_vitamin_homeostasis	1.79851066
21	MP0004142_abnormal_muscle_tone	1.65755182
22	MP0005379_endocrine/exocrine_gland_phen	1.59060238
23	MP0004264_abnormal_extraembryonic_tissu	1.54561910
24	MP0010307_abnormal_tumor_latency	1.43319387
25	MP0008058_abnormal_DNA_repair	1.38253154
26	MP0005367_renal/urinary_system_phenotyp	1.28693315
27	MP0000516_abnormal_urinary_system	1.28693315
28	MP0004145_abnormal_muscle_electrophysio	1.25407466
29	MP0001666_abnormal_nutrient_absorption	1.22557915
30	MP0003183_abnormal_peptide_metabolism	1.21327357
31	MP0005410_abnormal_fertilization	1.21181856
32	MP0001986_abnormal_taste_sensitivity	1.20037041
33	MP0002822_catalepsy	1.13418341
34	MP0005253_abnormal_eye_physiology	1.13226720
35	MP0005365_abnormal_bile_salt	1.10841793
36	MP0004782_abnormal_surfactant_physiolog	1.10196051
37	MP0005332_abnormal_amino_acid	1.08727288
38	MP0009643_abnormal_urine_homeostasis	1.06055429
39	MP0005636_abnormal_mineral_homeostasis	1.05544745
40	MP0000003_abnormal_adipose_tissue	1.04865134
41	MP0002254_reproductive_system_inflammat	1.04767911
42	MP0008057_abnormal_DNA_replication	1.01900443
43	MP0005389_reproductive_system_phenotype	0.99826771
44	MP0006292_abnormal_olfactory_placode	0.97776947
45	MP0003718_maternal_effect	0.95645616
46	MP0002160_abnormal_reproductive_system	0.95389163
47	MP0001919_abnormal_reproductive_system	0.92931828
48	MP0010155_abnormal_intestine_physiology	0.92716414
49	MP0001324_abnormal_eye_pigmentation	0.91356153
50	MP0003656_abnormal_erythrocyte_physiolo	0.90399747
51	MP0001790_abnormal_immune_system	0.87726296
52	MP0005387_immune_system_phenotype	0.87726296
53	MP0000427_abnormal_hair_cycle	0.87501363
54	MP0005171_absent_coat_pigmentation	0.87090846
55	MP0002557_abnormal_social/conspecific_i	0.83247346
56	MP0008877_abnormal_DNA_methylation	0.82541297
57	MP0000681_abnormal_thyroid_gland	0.80405014
58	MP0010352_gastrointestinal_tract_polyps	0.79140148
59	MP0001764_abnormal_homeostasis	0.79100562
60	MP0001293_anophthalmia	0.78485720
61	MP0000653_abnormal_sex_gland	0.78142505
62	MP0002166_altered_tumor_susceptibility	0.78021181
63	MP0001119_abnormal_female_reproductive	0.78010556
64	MP0010094_abnormal_chromosome_stability	0.77198508
65	MP0001485_abnormal_pinna_reflex	0.76505762
66	MP0003943_abnormal_hepatobiliary_system	0.75589712
67	MP0005220_abnormal_exocrine_pancreas	0.75144003
68	MP0006036_abnormal_mitochondrial_physio	0.74921174
69	MP0002295_abnormal_pulmonary_circulatio	0.74162482
70	MP0002118_abnormal_lipid_homeostasis	0.73553312
71	MP0005075_abnormal_melanosome_morpholog	0.73220228
72	MP0005646_abnormal_pituitary_gland	0.72781401
73	MP0002210_abnormal_sex_determination	0.68274301
74	MP0003195_calcinosis	0.67046895
75	MP0001800_abnormal_humoral_immune	0.67043070
76	MP0000639_abnormal_adrenal_gland	0.65929227
77	MP0009697_abnormal_copulation	0.65168255
78	MP0001145_abnormal_male_reproductive	0.63354095
79	MP0005397_hematopoietic_system_phenotyp	0.63163931
80	MP0001545_abnormal_hematopoietic_system	0.63163931
81	MP0002733_abnormal_thermal_nociception	0.59526356
82	MP0009642_abnormal_blood_homeostasis	0.59241373
83	MP0003699_abnormal_female_reproductive	0.58582884
84	MP0003011_delayed_dark_adaptation	0.58007449
85	MP0004043_abnormal_pH_regulation	0.56299810
86	MP0002090_abnormal_vision	0.55254157
87	MP0001929_abnormal_gametogenesis	0.55254000
88	MP0002138_abnormal_hepatobiliary_system	0.55235704
89	MP0005535_abnormal_body_temperature	0.55064408
90	MP0003698_abnormal_male_reproductive	0.54058434
91	MP0002405_respiratory_system_inflammati	0.53448204
92	MP0002693_abnormal_pancreas_physiology	0.52998364
93	MP0002148_abnormal_hypersensitivity_rea	0.51396007
94	MP0001502_abnormal_circadian_rhythm	0.50747567
95	MP0002734_abnormal_mechanical_nocicepti	0.50598325
96	MP0000371_diluted_coat_color	0.50482241
97	MP0003632_abnormal_nervous_system	0.50444052
98	MP0005671_abnormal_response_to	0.50369815
99	MP0009333_abnormal_splenocyte_physiolog	0.49094482
100	MP0002229_neurodegeneration	0.48743698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	7.68824005
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.26100005
3	Abnormality of alanine metabolism (HP:0010916)	7.26100005
4	Hyperalaninemia (HP:0003348)	7.26100005
5	Hyperlipoproteinemia (HP:0010980)	5.10573802
6	Microretrognathia (HP:0000308)	4.28740527
7	Decreased central vision (HP:0007663)	3.96553383
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.96111730
9	Hypolipoproteinemia (HP:0010981)	3.91815594
10	Diastasis recti (HP:0001540)	3.76944436
11	Abnormality of serum amino acid levels (HP:0003112)	3.75890508
12	Malnutrition (HP:0004395)	3.72952211
13	Type 2 muscle fiber atrophy (HP:0003554)	3.59078127
14	Dyschromatopsia (HP:0007641)	3.58043864
15	Pigmentary retinal degeneration (HP:0001146)	3.56920362
16	Cone-rod dystrophy (HP:0000548)	3.37064329
17	Abnormality of macular pigmentation (HP:0008002)	3.34033557
18	Abnormality of pyrimidine metabolism (HP:0004353)	3.29380205
19	Vacuolated lymphocytes (HP:0001922)	3.21232056
20	Nausea (HP:0002018)	3.05703016
21	Hypomagnesemia (HP:0002917)	2.97705018
22	Muscle fiber atrophy (HP:0100295)	2.92422271
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.86285171
24	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.83022054
25	Cutaneous melanoma (HP:0012056)	2.82017851
26	Hyperglycinemia (HP:0002154)	2.79879075
27	Abolished electroretinogram (ERG) (HP:0000550)	2.71634500
28	Truncal obesity (HP:0001956)	2.68184571
29	Macular degeneration (HP:0000608)	2.62959352
30	Proximal tubulopathy (HP:0000114)	2.62444541
31	J-shaped sella turcica (HP:0002680)	2.55759778
32	Renal cortical cysts (HP:0000803)	2.54794104
33	Increased corneal curvature (HP:0100692)	2.46667449
34	Keratoconus (HP:0000563)	2.46667449
35	Broad alveolar ridges (HP:0000187)	2.45868667
36	Tetany (HP:0001281)	2.42210294
37	Congenital sensorineural hearing impairment (HP:0008527)	2.38755888
38	Joint hemorrhage (HP:0005261)	2.38636713
39	Abnormality of magnesium homeostasis (HP:0004921)	2.38503741
40	Aplastic anemia (HP:0001915)	2.36973197
41	Hypoplasia of the uterus (HP:0000013)	2.34606748
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.34183279
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.34183279
44	Abnormality of midbrain morphology (HP:0002418)	2.33639066
45	Molar tooth sign on MRI (HP:0002419)	2.33639066
46	Abnormality of liposaccharide metabolism (HP:0010968)	2.31688670
47	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.31688670
48	Abnormality of glycolipid metabolism (HP:0010969)	2.31688670
49	Pendular nystagmus (HP:0012043)	2.22034545
50	Central scotoma (HP:0000603)	2.17757236
51	Prolonged partial thromboplastin time (HP:0003645)	2.15790333
52	Abnormality of macrophages (HP:0004311)	2.15764366
53	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.11277005
54	Genital tract atresia (HP:0001827)	2.09925042
55	Hypoplastic pelvis (HP:0008839)	2.09509467
56	Rhinitis (HP:0012384)	2.04384832
57	Facial diplegia (HP:0001349)	2.02884438
58	Vaginal atresia (HP:0000148)	2.02190656
59	Congenital stationary night blindness (HP:0007642)	2.01286839
60	Congenital primary aphakia (HP:0007707)	1.98911948
61	Severe visual impairment (HP:0001141)	1.96667177
62	Acute lymphatic leukemia (HP:0006721)	1.94829190
63	Acanthocytosis (HP:0001927)	1.94056630
64	Abnormality of vitamin B metabolism (HP:0004340)	1.90960235
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.88316056
66	Gait imbalance (HP:0002141)	1.87854838
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.86639077
68	Dysostosis multiplex (HP:0000943)	1.85849105
69	Delayed CNS myelination (HP:0002188)	1.84972933
70	Medial flaring of the eyebrow (HP:0010747)	1.84669665
71	Abnormality of the renal cortex (HP:0011035)	1.84417185
72	Inability to walk (HP:0002540)	1.83041953
73	Prolonged neonatal jaundice (HP:0006579)	1.80820374
74	Hypoplasia of the iris (HP:0007676)	1.77831480
75	Metabolic acidosis (HP:0001942)	1.75697112
76	Abnormality of the prostate (HP:0008775)	1.75319439
77	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.73482580
78	Nonprogressive disorder (HP:0003680)	1.73277632
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73114678
80	Dysdiadochokinesis (HP:0002075)	1.69224899
81	Inappropriate behavior (HP:0000719)	1.68640820
82	Abnormality of glycine metabolism (HP:0010895)	1.68426345
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.68426345
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68322689
85	Panhypogammaglobulinemia (HP:0003139)	1.68045936
86	Chronic sinusitis (HP:0011109)	1.67965731
87	Hyperinsulinemic hypoglycemia (HP:0000825)	1.67963824
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67553616
89	Hypochromic microcytic anemia (HP:0004840)	1.65194883
90	Nephrogenic diabetes insipidus (HP:0009806)	1.64766617
91	Hyperammonemia (HP:0001987)	1.64667486
92	3-Methylglutaconic aciduria (HP:0003535)	1.64637396
93	Methylmalonic acidemia (HP:0002912)	1.64360843
94	Attenuation of retinal blood vessels (HP:0007843)	1.63692188
95	Progressive inability to walk (HP:0002505)	1.62793516
96	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.61796340
97	Stenosis of the external auditory canal (HP:0000402)	1.60816690
98	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.60438559
99	Ectropion (HP:0000656)	1.60063807
100	Flared iliac wings (HP:0002869)	1.58803678

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	7.82496681
2	MUSK	6.84626821
3	MAP4K2	3.95962107
4	TNIK	3.68497683
5	BCKDK	2.65855697
6	MAP3K12	2.63922326
7	TXK	2.49037166
8	NLK	2.39057268
9	TESK2	2.31766002
10	FLT3	2.11096195
11	PDK2	2.05252784
12	FRK	1.96744285
13	TAOK3	1.95980351
14	WNK3	1.95914662
15	ACVR1B	1.68967426
16	MAP3K6	1.61158721
17	MAP3K4	1.57518292
18	CSF1R	1.50264810
19	MAP2K3	1.48793774
20	ERBB3	1.44834423
21	RPS6KA4	1.27388371
22	KIT	1.19645251
23	MAP2K6	1.16395994
24	MAP2K4	1.14495101
25	MYLK	1.09562295
26	BRSK2	1.07057961
27	STK38L	1.05514105
28	YES1	1.02855268
29	BMPR1B	1.02682610
30	PRKCE	0.93773964
31	FGFR2	0.92431247
32	TRIM28	0.88537823
33	TNK2	0.86975858
34	GRK1	0.85296157
35	PTK2B	0.83622215
36	PIK3CA	0.82856449
37	WEE1	0.82052419
38	MATK	0.77300922
39	SYK	0.75208934
40	TRPM7	0.74905226
41	PAK3	0.73633477
42	NUAK1	0.71741519
43	ADRBK2	0.66931866
44	PASK	0.66831184
45	EIF2AK1	0.61270607
46	DYRK3	0.58973245
47	RET	0.56656170
48	NTRK3	0.56093026
49	MAP2K7	0.55658162
50	MKNK2	0.54054121
51	ZAP70	0.49382377
52	PBK	0.49349918
53	MKNK1	0.47356707
54	PRKG2	0.45377745
55	NME1	0.44325632
56	RPS6KB2	0.44006166
57	EIF2AK3	0.43997795
58	TLK1	0.43977417
59	SGK2	0.42194504
60	ITK	0.40564080
61	ADRBK1	0.40540283
62	PRKACB	0.39158793
63	TGFBR1	0.38717714
64	NEK6	0.36652507
65	TEC	0.36035009
66	CSK	0.34804735
67	PRKCG	0.34280875
68	CDK8	0.33450322
69	PINK1	0.32414604
70	FGFR1	0.31577785
71	CDK4	0.31444432
72	ABL2	0.31125827
73	CSNK2A1	0.27388586
74	STK3	0.27108639
75	CDK6	0.26627384
76	CSNK1G2	0.24929820
77	HIPK2	0.24525241
78	STK11	0.24210736
79	PRKAA2	0.24072530
80	PDK1	0.23448107
81	PKN1	0.21627399
82	STK24	0.21220569
83	SGK494	0.20194994
84	SGK223	0.20194994
85	PRKCA	0.19999493
86	PRKACG	0.19405028
87	CSNK2A2	0.18724198
88	RPS6KB1	0.17642748
89	STK39	0.17339706
90	IGF1R	0.16679895
91	HCK	0.16350425
92	MINK1	0.15836635
93	ROCK1	0.15229532
94	MAP3K5	0.15182864
95	AURKB	0.15056481
96	MAP3K7	0.14522851
97	ROCK2	0.12674016
98	CAMKK2	0.12369107
99	RIPK4	0.12251828
100	DAPK3	0.12231161

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin digestion and absorption_Homo sapiens_hsa04977	5.48244959
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.84824049
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.29711434
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.95685560
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.94535851
6	Proteasome_Homo sapiens_hsa03050	2.79974998
7	Galactose metabolism_Homo sapiens_hsa00052	2.57781803
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.44053606
9	Sphingolipid metabolism_Homo sapiens_hsa00600	2.30294484
10	Mineral absorption_Homo sapiens_hsa04978	2.06316106
11	Protein export_Homo sapiens_hsa03060	1.93747428
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.70301983
13	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.68234620
14	Chemical carcinogenesis_Homo sapiens_hsa05204	1.65268137
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64382056
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.52350803
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.52214111
18	Allograft rejection_Homo sapiens_hsa05330	1.50969201
19	Complement and coagulation cascades_Homo sapiens_hsa04610	1.45467084
20	Regulation of autophagy_Homo sapiens_hsa04140	1.44339150
21	Taste transduction_Homo sapiens_hsa04742	1.40593393
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39062264
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.37872883
24	Asthma_Homo sapiens_hsa05310	1.34877726
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.31744120
26	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.30166305
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.27773409
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27752977
29	Phototransduction_Homo sapiens_hsa04744	1.25085538
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.23626886
31	Butanoate metabolism_Homo sapiens_hsa00650	1.21288747
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.18514107
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15293391
34	African trypanosomiasis_Homo sapiens_hsa05143	1.13497918
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.09393264
36	Purine metabolism_Homo sapiens_hsa00230	1.06441041
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03714191
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03449719
39	PPAR signaling pathway_Homo sapiens_hsa03320	1.00882531
40	GnRH signaling pathway_Homo sapiens_hsa04912	0.98452995
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96956976
42	Propanoate metabolism_Homo sapiens_hsa00640	0.96128422
43	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.95779743
44	RNA degradation_Homo sapiens_hsa03018	0.91887093
45	Fatty acid elongation_Homo sapiens_hsa00062	0.90751063
46	Pentose phosphate pathway_Homo sapiens_hsa00030	0.90593464
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90450491
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89069894
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.85266508
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85181630
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.85012466
52	Peroxisome_Homo sapiens_hsa04146	0.84968301
53	Folate biosynthesis_Homo sapiens_hsa00790	0.83406840
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.83158440
55	ABC transporters_Homo sapiens_hsa02010	0.81242782
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.80949962
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.80738230
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.76403627
59	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.75119963
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.73265204
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.72380172
62	Homologous recombination_Homo sapiens_hsa03440	0.71731134
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71028629
64	RNA transport_Homo sapiens_hsa03013	0.70021006
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69598520
66	Retinol metabolism_Homo sapiens_hsa00830	0.69097940
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68958800
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66668956
69	Metabolic pathways_Homo sapiens_hsa01100	0.65541548
70	One carbon pool by folate_Homo sapiens_hsa00670	0.61250858
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60972607
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59099887
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57864016
74	Caffeine metabolism_Homo sapiens_hsa00232	0.57674538
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56711704
76	Circadian rhythm_Homo sapiens_hsa04710	0.55601448
77	Nicotine addiction_Homo sapiens_hsa05033	0.55542533
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54012770
79	Base excision repair_Homo sapiens_hsa03410	0.53929813
80	RNA polymerase_Homo sapiens_hsa03020	0.52903222
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.51253685
82	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.50040798
83	Glutathione metabolism_Homo sapiens_hsa00480	0.49922834
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47178612
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42537188
86	Salivary secretion_Homo sapiens_hsa04970	0.41751206
87	Carbon metabolism_Homo sapiens_hsa01200	0.41376600
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.39999606
89	Morphine addiction_Homo sapiens_hsa05032	0.39087462
90	Other glycan degradation_Homo sapiens_hsa00511	0.37934899
91	Salmonella infection_Homo sapiens_hsa05132	0.34255895
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30244256
93	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29818911
94	Histidine metabolism_Homo sapiens_hsa00340	0.29497632
95	Olfactory transduction_Homo sapiens_hsa04740	0.29298934
96	Serotonergic synapse_Homo sapiens_hsa04726	0.27279679
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.26473550
98	Fatty acid degradation_Homo sapiens_hsa00071	0.25232240
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.23608173
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23268525

ARF4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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