ARF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)4.88512414
2protoporphyrinogen IX metabolic process (GO:0046501)4.70290833
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.58939563
4Golgi transport vesicle coating (GO:0048200)4.58894791
5porphyrin-containing compound biosynthetic process (GO:0006779)4.47915459
6protoporphyrinogen IX biosynthetic process (GO:0006782)4.21701145
7GDP-mannose metabolic process (GO:0019673)4.14951380
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01358301
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01358301
10heme metabolic process (GO:0042168)3.99607490
11tetrapyrrole biosynthetic process (GO:0033014)3.79749406
12porphyrin-containing compound metabolic process (GO:0006778)3.70239199
13negative regulation of erythrocyte differentiation (GO:0045647)3.56844593
14maternal placenta development (GO:0001893)3.53336498
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44038257
16erythrocyte maturation (GO:0043249)3.43841897
17antigen processing and presentation of endogenous antigen (GO:0019883)3.43446506
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.37539552
19hemoglobin metabolic process (GO:0020027)3.34429960
20neutrophil activation involved in immune response (GO:0002283)3.31875170
21regulation of early endosome to late endosome transport (GO:2000641)3.31640302
22protein retention in ER lumen (GO:0006621)3.26269034
23glucose catabolic process (GO:0006007)3.25795573
24deoxyribose phosphate biosynthetic process (GO:0046385)3.24691460
252-deoxyribonucleotide biosynthetic process (GO:0009265)3.24691460
26regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.22728620
27NADPH regeneration (GO:0006740)3.18467658
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18196573
29sequestering of actin monomers (GO:0042989)3.18151136
30proline biosynthetic process (GO:0006561)3.10749869
31barbed-end actin filament capping (GO:0051016)3.10583741
32pentose metabolic process (GO:0019321)3.10143421
33sulfur amino acid catabolic process (GO:0000098)3.09084618
34NADH metabolic process (GO:0006734)3.08032937
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.05019912
36NIK/NF-kappaB signaling (GO:0038061)2.98019982
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96762802
38phospholipid efflux (GO:0033700)2.95922286
39pyrimidine nucleoside salvage (GO:0043097)2.91436958
40pyrimidine-containing compound salvage (GO:0008655)2.91436958
41mitotic nuclear envelope reassembly (GO:0007084)2.88356065
42nuclear envelope reassembly (GO:0031468)2.88356065
43virion assembly (GO:0019068)2.87440691
44purine deoxyribonucleotide catabolic process (GO:0009155)2.87386803
45cellular response to virus (GO:0098586)2.81717884
46plasma lipoprotein particle assembly (GO:0034377)2.80538695
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79628371
48peptidyl-arginine omega-N-methylation (GO:0035247)2.78895401
49decidualization (GO:0046697)2.73910681
50negative regulation of cholesterol transport (GO:0032375)2.73704157
51negative regulation of sterol transport (GO:0032372)2.73704157
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73468649
53endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.71505787
54protein-lipid complex assembly (GO:0065005)2.70791487
55natural killer cell differentiation (GO:0001779)2.70161711
56nucleoside diphosphate biosynthetic process (GO:0009133)2.69885793
57amyloid precursor protein catabolic process (GO:0042987)2.69700769
58L-alpha-amino acid transmembrane transport (GO:1902475)2.68402163
59regulation of cholesterol storage (GO:0010885)2.68274161
60regulation of superoxide anion generation (GO:0032928)2.67568296
61desmosome organization (GO:0002934)2.67502162
62positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.66968718
63protein insertion into membrane (GO:0051205)2.66946859
64platelet formation (GO:0030220)2.66620365
65detection of bacterium (GO:0016045)2.66373769
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.65296592
67immunoglobulin mediated immune response (GO:0016064)2.64911209
68negative regulation of cell size (GO:0045792)2.64336501
69viral protein processing (GO:0019082)2.63281483
70peptidyl-glutamic acid carboxylation (GO:0017187)2.63197041
71protein carboxylation (GO:0018214)2.63197041
72regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62552168
73negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.62036250
74glucose 6-phosphate metabolic process (GO:0051156)2.61140465
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.60504770
76negative regulation of cell killing (GO:0031342)2.60504770
77lipopolysaccharide biosynthetic process (GO:0009103)2.58088918
78modulation by virus of host process (GO:0019054)2.57838856
79deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.57775250
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57585531
81negative regulation of myeloid cell apoptotic process (GO:0033033)2.57425623
82positive regulation by symbiont of host defense response (GO:0052509)2.57228732
83modulation by symbiont of host defense response (GO:0052031)2.57228732
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57228732
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57228732
86positive regulation by organism of defense response of other organism involved in symbiotic interact2.57228732
87modulation by symbiont of host immune response (GO:0052553)2.57228732
88regulation of cholesterol homeostasis (GO:2000188)2.57159536
89prostaglandin biosynthetic process (GO:0001516)2.57017437
90prostanoid biosynthetic process (GO:0046457)2.57017437
91deoxyribonucleotide catabolic process (GO:0009264)2.56134576
92positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.56062193
93low-density lipoprotein particle clearance (GO:0034383)2.53391332
94regulation of cholesterol esterification (GO:0010872)2.51533500
95hydrogen peroxide biosynthetic process (GO:0050665)2.50942959
96amino sugar catabolic process (GO:0046348)2.50605845
97negative regulation of fibrinolysis (GO:0051918)2.48944298
98detection of other organism (GO:0098543)2.48328037
99nucleotide salvage (GO:0043173)2.47755153
100lipopolysaccharide metabolic process (GO:0008653)2.47649505
101plasma lipoprotein particle clearance (GO:0034381)2.47441236
102pinocytosis (GO:0006907)2.47103335
103deoxyribose phosphate catabolic process (GO:0046386)2.46928849
104positive thymic T cell selection (GO:0045059)2.46261585
105response to peptidoglycan (GO:0032494)2.45876918
106positive regulation of fatty acid biosynthetic process (GO:0045723)2.45719772
107regulation of mitochondrial membrane potential (GO:0051881)2.45114963
108pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44004772
109protein maturation by protein folding (GO:0022417)2.43421306
110mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43213229
111positive regulation of reactive oxygen species metabolic process (GO:2000379)2.42048557
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41940588
113glycosphingolipid catabolic process (GO:0046479)2.40396407
114positive regulation of lamellipodium assembly (GO:0010592)2.40204158
115activation of MAPKKK activity (GO:0000185)2.39971385
116regulation of autophagic vacuole assembly (GO:2000785)2.39604602
117platelet aggregation (GO:0070527)2.38897271
118respiratory burst (GO:0045730)2.38819989
119modulation by symbiont of host cellular process (GO:0044068)2.38343975
120mitochondrial calcium ion transport (GO:0006851)2.38186414
121response to type I interferon (GO:0034340)2.38036581
122monosaccharide biosynthetic process (GO:0046364)2.37672463
123L-phenylalanine metabolic process (GO:0006558)2.36574356
124erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36574356
125antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.35979725
126regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.35360010
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35049258
128positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34981068
129regulation of erythrocyte differentiation (GO:0045646)2.34689741
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.34570315
131actin nucleation (GO:0045010)2.32634357
132guanosine-containing compound biosynthetic process (GO:1901070)2.32586308
133regulation of release of cytochrome c from mitochondria (GO:0090199)2.32078707
134regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31810498
135actin filament polymerization (GO:0030041)2.31756660
136adenine nucleotide transport (GO:0051503)2.31107890
137positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.30954852
138type I interferon signaling pathway (GO:0060337)2.30698546
139cellular response to type I interferon (GO:0071357)2.30698546
140chaperone mediated protein folding requiring cofactor (GO:0051085)2.30570542
141positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.30299898
142lipoxygenase pathway (GO:0019372)2.30269660
143leukocyte aggregation (GO:0070486)2.28614283
144establishment of viral latency (GO:0019043)2.28121967
145phagosome maturation (GO:0090382)2.28000319
146tricarboxylic acid metabolic process (GO:0072350)2.27723075
147positive regulation of triglyceride biosynthetic process (GO:0010867)2.27453951
148negative regulation of B cell apoptotic process (GO:0002903)2.27080160
149UV protection (GO:0009650)2.26753872
150purine deoxyribonucleotide metabolic process (GO:0009151)2.25979704
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.25452538
152nitric oxide biosynthetic process (GO:0006809)2.25224193
153regulation of fibrinolysis (GO:0051917)2.24101194
154high-density lipoprotein particle remodeling (GO:0034375)2.22989808
155primary alcohol catabolic process (GO:0034310)2.22880800
156tetrapyrrole metabolic process (GO:0033013)2.22469352
157positive regulation of triglyceride metabolic process (GO:0090208)2.21423361
158endothelial cell chemotaxis (GO:0035767)2.21415246
159apoptotic cell clearance (GO:0043277)2.21125225
160positive regulation of lipid catabolic process (GO:0050996)2.19609922
161positive regulation of nitric-oxide synthase activity (GO:0051000)2.19404985
162cysteine metabolic process (GO:0006534)2.18281285
163very-low-density lipoprotein particle assembly (GO:0034379)2.17845039
164activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.15811073
165acute-phase response (GO:0006953)2.15578706
166negative regulation of protein oligomerization (GO:0032460)2.14418498
167regulation of defense response to virus by virus (GO:0050690)2.14223095
168negative regulation of actin filament polymerization (GO:0030837)2.13909883
169pentose-phosphate shunt (GO:0006098)2.13371209
1704-hydroxyproline metabolic process (GO:0019471)2.13238048
171regulation of ruffle assembly (GO:1900027)2.12592943
172CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.12368479
173cellular modified amino acid catabolic process (GO:0042219)2.11567917
174stress fiber assembly (GO:0043149)2.10164672
175urea metabolic process (GO:0019627)2.09449525
176urea cycle (GO:0000050)2.09449525
177positive regulation of nuclease activity (GO:0032075)2.08380741
178sexual reproduction (GO:0019953)2.08138000
179antigen processing and presentation via MHC class Ib (GO:0002475)2.07519183
180reactive oxygen species biosynthetic process (GO:1903409)2.06843135
181positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.06740445
182COPI coating of Golgi vesicle (GO:0048205)2.05899041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.87190208
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.43580606
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84664856
4LXR_22292898_ChIP-Seq_THP-1_Human2.83358951
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63170727
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.56172937
7SRY_22984422_ChIP-ChIP_TESTIS_Rat2.54226283
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52219585
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38004819
10VDR_21846776_ChIP-Seq_THP-1_Human2.37830458
11MYC_22102868_ChIP-Seq_BL_Human2.33174674
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29568458
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.26063917
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22529892
15* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19903441
16KDM2B_26808549_Chip-Seq_DND41_Human2.10454695
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.07194938
18* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05091966
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03209473
20ZNF263_19887448_ChIP-Seq_K562_Human1.97527437
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93828749
22RACK7_27058665_Chip-Seq_MCF-7_Human1.89993224
23TCF7_22412390_ChIP-Seq_EML_Mouse1.85941833
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.85555033
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.82678635
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82206126
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81895229
28MAF_26560356_Chip-Seq_TH1_Human1.80009793
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72795067
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.66520625
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65817099
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64808110
33GATA1_19941826_ChIP-Seq_K562_Human1.63230216
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62935805
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62001231
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60815574
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.60537431
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58377747
39* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57772464
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56529491
41UTX_26944678_Chip-Seq_JUKART_Human1.56195412
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.55567771
43KDM2B_26808549_Chip-Seq_K562_Human1.54289182
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53484815
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52653734
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51782336
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50503898
48VDR_24763502_ChIP-Seq_THP-1_Human1.50246094
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49419161
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.48601122
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46294312
52CREB1_26743006_Chip-Seq_LNCaP_Human1.45344753
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44518955
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43793358
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43210693
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41273061
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41204602
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41101765
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39825136
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.39775699
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38756496
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.38646105
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37139948
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.36451432
65MAF_26560356_Chip-Seq_TH2_Human1.35415385
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35153815
67ATF3_27146783_Chip-Seq_COLON_Human1.34567627
68CLOCK_20551151_ChIP-Seq_293T_Human1.34563031
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30809941
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30405924
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29721698
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29466301
73BCL6_27268052_Chip-Seq_Bcells_Human1.29273195
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29163431
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27427104
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27038542
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26831233
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26179264
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25858594
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25169243
81XRN2_22483619_ChIP-Seq_HELA_Human1.24656583
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.24305797
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24124714
84P68_20966046_ChIP-Seq_HELA_Human1.24118513
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24109801
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23742045
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23637748
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.23128461
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22874294
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.20767439
91BCOR_27268052_Chip-Seq_Bcells_Human1.20339754
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19372331
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18906834
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18268510
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18025120
96CTCF_21964334_Chip-Seq_Bcells_Human1.17425930
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17425271
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17120017
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16543122
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16345939
101EGR1_19032775_ChIP-ChIP_M12_Human1.16264032
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15953733
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15653230
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.15124903
105CTCF_27219007_Chip-Seq_Bcells_Human1.13926617
106SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13514432
107SA1_27219007_Chip-Seq_Bcells_Human1.12104723
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.12081931
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11688392
110* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10917129
111NCOR1_26117541_ChIP-Seq_K562_Human1.10063029
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09325717
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09221136
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09153618
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08648955
116* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08101023
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08050305
118GATA2_19941826_ChIP-Seq_K562_Human1.06642435
119NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06181703
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.06045054
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06037149
122* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05728123
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05306844
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04819375
125SPI1_23547873_ChIP-Seq_NB4_Human1.04328753
126OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03940318
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03804861
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03715143
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03298123
130MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03081201
131PHF8_20622854_ChIP-Seq_HELA_Human1.02991431
132SCL_19346495_ChIP-Seq_HPC-7_Human1.01707833
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01387431
134* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01262877
135* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00963999
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00916180
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00064741
138SPI1_20517297_ChIP-Seq_HL60_Human0.97980066
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97585394
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96897966
141SMC4_20622854_ChIP-Seq_HELA_Human0.96395291
142SPI1_23127762_ChIP-Seq_K562_Human0.96167668
143* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94953606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.74085241
2MP0008260_abnormal_autophagy3.69476778
3MP0005451_abnormal_body_composition3.66272048
4MP0005083_abnormal_biliary_tract3.56939154
5MP0003656_abnormal_erythrocyte_physiolo3.54628261
6MP0010234_abnormal_vibrissa_follicle3.31779754
7MP0002139_abnormal_hepatobiliary_system3.26871586
8MP0003436_decreased_susceptibility_to3.19726588
9MP0000685_abnormal_immune_system2.80293685
10MP0003705_abnormal_hypodermis_morpholog2.79677866
11MP0005360_urolithiasis2.74960340
12MP0004510_myositis2.70366767
13MP0009840_abnormal_foam_cell2.40329819
14MP0003191_abnormal_cellular_cholesterol2.33989889
15MP0003300_gastrointestinal_ulcer2.17669325
16MP0005085_abnormal_gallbladder_physiolo2.11611570
17MP0004858_abnormal_nervous_system1.94527482
18MP0009785_altered_susceptibility_to1.87544730
19MP0006082_CNS_inflammation1.85071869
20MP0003453_abnormal_keratinocyte_physiol1.82804169
21MP0004947_skin_inflammation1.76527136
22MP0003806_abnormal_nucleotide_metabolis1.75447350
23MP0005464_abnormal_platelet_physiology1.74779772
24MP0003724_increased_susceptibility_to1.71026444
25MP0005025_abnormal_response_to1.69091158
26MP0003075_altered_response_to1.64856367
27MP0000465_gastrointestinal_hemorrhage1.62039313
28MP0002822_catalepsy1.60159052
29MP0005058_abnormal_lysosome_morphology1.58651179
30MP0005365_abnormal_bile_salt1.58448026
31MP0005000_abnormal_immune_tolerance1.54737539
32MP0001835_abnormal_antigen_presentation1.51764275
33MP0000490_abnormal_crypts_of1.51639358
34MP0000858_altered_metastatic_potential1.50900091
35MP0001533_abnormal_skeleton_physiology1.49058766
36MP0005076_abnormal_cell_differentiation1.42468155
37MP0010329_abnormal_lipoprotein_level1.42397088
38MP0000609_abnormal_liver_physiology1.41030903
39MP0002796_impaired_skin_barrier1.39849736
40MP0005166_decreased_susceptibility_to1.38881843
41MP0010155_abnormal_intestine_physiology1.38814705
42MP0005275_abnormal_skin_tensile1.34298529
43MP0001790_abnormal_immune_system1.33946340
44MP0005387_immune_system_phenotype1.33946340
45MP0008875_abnormal_xenobiotic_pharmacok1.33444128
46MP0003866_abnormal_defecation1.32579735
47MP0000678_abnormal_parathyroid_gland1.32505152
48MP0008961_abnormal_basal_metabolism1.30243890
49MP0001666_abnormal_nutrient_absorption1.29979321
50MP0005397_hematopoietic_system_phenotyp1.28909928
51MP0001545_abnormal_hematopoietic_system1.28909928
52MP0005636_abnormal_mineral_homeostasis1.28024129
53MP0005671_abnormal_response_to1.25131071
54MP0000604_amyloidosis1.23817940
55MP0000681_abnormal_thyroid_gland1.23693891
56MP0001663_abnormal_digestive_system1.21900535
57MP0002419_abnormal_innate_immunity1.21035641
58MP0001853_heart_inflammation1.20698117
59MP0002138_abnormal_hepatobiliary_system1.20196724
60MP0005501_abnormal_skin_physiology1.17368477
61MP0008469_abnormal_protein_level1.16885987
62MP0001348_abnormal_lacrimal_gland1.16194681
63MP0003283_abnormal_digestive_organ1.15850395
64MP0003329_amyloid_beta_deposits1.14992981
65MP0003566_abnormal_cell_adhesion1.13866818
66MP0001845_abnormal_inflammatory_respons1.13827864
67MP0008874_decreased_physiological_sensi1.13557986
68MP0002723_abnormal_immune_serum1.12798138
69MP0009764_decreased_sensitivity_to1.12516374
70MP0005165_increased_susceptibility_to1.12235043
71MP0002405_respiratory_system_inflammati1.11126980
72MP0002166_altered_tumor_susceptibility1.10295069
73MP0010352_gastrointestinal_tract_polyps1.10181906
74MP0001819_abnormal_immune_cell1.08977631
75MP0002452_abnormal_antigen_presenting1.08887121
76MP0008438_abnormal_cutaneous_collagen1.08358333
77MP0002909_abnormal_adrenal_gland1.08290201
78MP0003183_abnormal_peptide_metabolism1.06970603
79MP0002148_abnormal_hypersensitivity_rea1.06922152
80MP0000750_abnormal_muscle_regeneration1.06049860
81MP0002420_abnormal_adaptive_immunity1.05682086
82MP0009333_abnormal_splenocyte_physiolog1.04681174
83MP0004859_abnormal_synaptic_plasticity1.03242059
84MP0000343_altered_response_to1.03159483
85MP0003448_altered_tumor_morphology1.02894857
86MP0008004_abnormal_stomach_pH1.02240350
87MP0005319_abnormal_enzyme/_coenzyme1.01772852
88MP0002877_abnormal_melanocyte_morpholog1.00992293
89MP0005381_digestive/alimentary_phenotyp0.99936521
90MP0001800_abnormal_humoral_immune0.99792529
91MP0009643_abnormal_urine_homeostasis0.98569031
92MP0002398_abnormal_bone_marrow0.98076844
93MP0009931_abnormal_skin_appearance0.97871911
94MP0006036_abnormal_mitochondrial_physio0.96646436
95MP0005584_abnormal_enzyme/coenzyme_acti0.95406270
96MP0005390_skeleton_phenotype0.93256468
97MP0003252_abnormal_bile_duct0.93152298
98MP0002132_abnormal_respiratory_system0.92998841
99MP0000751_myopathy0.92684140
100MP0002249_abnormal_larynx_morphology0.92439212
101MP0009278_abnormal_bone_marrow0.92299935
102MP0005023_abnormal_wound_healing0.91260794
103MP0005310_abnormal_salivary_gland0.90977393
104MP0001905_abnormal_dopamine_level0.90792722
105MP0004185_abnormal_adipocyte_glucose0.89528150
106MP0001849_ear_inflammation0.89316480
107MP0002254_reproductive_system_inflammat0.86392401
108MP0003123_paternal_imprinting0.86390266
109MP0005666_abnormal_adipose_tissue0.86343005
110MP0002722_abnormal_immune_system0.85821710
111MP0000598_abnormal_liver_morphology0.84155656
112MP0002234_abnormal_pharynx_morphology0.83328222
113MP0002118_abnormal_lipid_homeostasis0.83204527
114MP0003186_abnormal_redox_activity0.82014129
115MP0000689_abnormal_spleen_morphology0.81476516
116MP0002429_abnormal_blood_cell0.81157778
117MP0002006_tumorigenesis0.81051562
118MP0003763_abnormal_thymus_physiology0.80938157
119MP0009053_abnormal_anal_canal0.80804658
120MP0002089_abnormal_postnatal_growth/wei0.79841299
121MP0000716_abnormal_immune_system0.78083364
122MP0005167_abnormal_blood-brain_barrier0.77679441
123MP0003172_abnormal_lysosome_physiology0.76952078
124MP0000703_abnormal_thymus_morphology0.76070286
125MP0002933_joint_inflammation0.75530989
126MP0010030_abnormal_orbit_morphology0.75471917
127MP0001873_stomach_inflammation0.75259489
128MP0000537_abnormal_urethra_morphology0.74955793
129MP0002998_abnormal_bone_remodeling0.72181987
130MP0006035_abnormal_mitochondrial_morpho0.71079886
131MP0009763_increased_sensitivity_to0.68380525
132MP0004381_abnormal_hair_follicle0.66234038
133MP0005375_adipose_tissue_phenotype0.66134605
134MP0001216_abnormal_epidermal_layer0.66088060
135MP0000920_abnormal_myelination0.65676412

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.12830206
2Reticulocytosis (HP:0001923)4.01874657
3Eczematoid dermatitis (HP:0000976)3.98959803
4Polycythemia (HP:0001901)3.51196191
5Abnormality of macrophages (HP:0004311)3.44669948
6Poikilocytosis (HP:0004447)3.37068103
7Abnormality of liposaccharide metabolism (HP:0010968)3.32002617
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.32002617
9Abnormality of glycolipid metabolism (HP:0010969)3.32002617
10Deep venous thrombosis (HP:0002625)3.27769076
11Hypercortisolism (HP:0001578)3.19994075
12Abnormality of the Achilles tendon (HP:0005109)3.11072933
13Achilles tendon contracture (HP:0001771)3.07166000
14Ragged-red muscle fibers (HP:0003200)2.97005196
15Recurrent gram-negative bacterial infections (HP:0005420)2.95586118
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95514226
17Xanthomatosis (HP:0000991)2.88670984
18Hyperbilirubinemia (HP:0002904)2.84421087
19Loss of speech (HP:0002371)2.83923357
20Hepatosplenomegaly (HP:0001433)2.80047746
21Late onset (HP:0003584)2.80028324
22Distal lower limb muscle weakness (HP:0009053)2.79170181
23Acanthocytosis (HP:0001927)2.77624003
24Protrusio acetabuli (HP:0003179)2.76979427
25Pustule (HP:0200039)2.73564536
26Chronic obstructive pulmonary disease (HP:0006510)2.72546064
27Obstructive lung disease (HP:0006536)2.72546064
28Multiple lipomas (HP:0001012)2.70688369
29Peritonitis (HP:0002586)2.65532260
30Cholelithiasis (HP:0001081)2.61384550
31Increased serum ferritin (HP:0003281)2.60198509
32Elevated erythrocyte sedimentation rate (HP:0003565)2.59303929
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.55853617
34Increased cerebral lipofuscin (HP:0011813)2.54559810
35Myopathic facies (HP:0002058)2.51342641
36Progressive neurologic deterioration (HP:0002344)2.49015415
37Prolonged neonatal jaundice (HP:0006579)2.47982301
38Abnormality of complement system (HP:0005339)2.43957457
39Increased IgM level (HP:0003496)2.42912938
40Neuronal loss in central nervous system (HP:0002529)2.41298326
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41112183
42Abnormal gallbladder morphology (HP:0012437)2.40526174
43Urticaria (HP:0001025)2.40404229
44Ankle clonus (HP:0011448)2.40290104
45Vertebral compression fractures (HP:0002953)2.39986474
46Supranuclear gaze palsy (HP:0000605)2.37954077
47J-shaped sella turcica (HP:0002680)2.36280953
48Abnormality of reticulocytes (HP:0004312)2.34783142
49Increased IgE level (HP:0003212)2.34384708
50Upper limb amyotrophy (HP:0009129)2.33316212
51Distal upper limb amyotrophy (HP:0007149)2.33316212
52Hyperparathyroidism (HP:0000843)2.32165252
53Systemic lupus erythematosus (HP:0002725)2.31266294
54Nasal polyposis (HP:0100582)2.28869283
55Insomnia (HP:0100785)2.28448837
56Joint hemorrhage (HP:0005261)2.28288315
57Hypertensive crisis (HP:0100735)2.24596788
58Interstitial pulmonary disease (HP:0006530)2.22246179
59Abnormality of iron homeostasis (HP:0011031)2.20266013
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19319098
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19319098
62Hand muscle atrophy (HP:0009130)2.17344429
63Abnormality of the nasal mucosa (HP:0000433)2.16248786
64Autoimmune thrombocytopenia (HP:0001973)2.15709815
65Menorrhagia (HP:0000132)2.12146330
66Urinary glycosaminoglycan excretion (HP:0003541)2.11828873
67Mucopolysacchariduria (HP:0008155)2.11828873
68Vacuolated lymphocytes (HP:0001922)2.11357200
69Complement deficiency (HP:0004431)2.10315657
70Rhabdomyolysis (HP:0003201)2.09820298
71Myocardial infarction (HP:0001658)2.09664656
72Recurrent abscess formation (HP:0002722)2.09216877
73Gastrointestinal dysmotility (HP:0002579)2.08780594
74Dysostosis multiplex (HP:0000943)2.08443300
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.08290309
76Deep palmar crease (HP:0006191)2.07647266
77Myositis (HP:0100614)2.07562912
78Purpura (HP:0000979)2.06006873
79Fragile skin (HP:0001030)2.05802447
80Mildly elevated creatine phosphokinase (HP:0008180)2.04693946
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03659156
82Verrucae (HP:0200043)2.02977647
83Papilloma (HP:0012740)2.02977647
84Abnormal platelet function (HP:0011869)2.00063760
85Impaired platelet aggregation (HP:0003540)2.00063760
86Abnormality of transition element cation homeostasis (HP:0011030)1.99721384
87Distal lower limb amyotrophy (HP:0008944)1.98132107
88Gastrointestinal infarctions (HP:0005244)1.98061503
89Petechiae (HP:0000967)1.96752821
90Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95888279
91Meningitis (HP:0001287)1.93711992
92Neonatal onset (HP:0003623)1.93164827
93Epistaxis (HP:0000421)1.92580630
94Agammaglobulinemia (HP:0004432)1.92055651
95Woolly hair (HP:0002224)1.90590214
96Axonal loss (HP:0003447)1.90463160
97Right ventricular cardiomyopathy (HP:0011663)1.90376836
98Hypochromic anemia (HP:0001931)1.90360098
99Abnormal gallbladder physiology (HP:0012438)1.89521516
100Cholecystitis (HP:0001082)1.89521516
101Cerebral aneurysm (HP:0004944)1.87993345
102Gingivitis (HP:0000230)1.87952425
103Hypergammaglobulinemia (HP:0010702)1.87910200
104Conjunctival hamartoma (HP:0100780)1.85838022
105Cellulitis (HP:0100658)1.85494467
106Multiple enchondromatosis (HP:0005701)1.85158784
107Generalized hyperpigmentation (HP:0007440)1.85026538
108Recurrent bacterial skin infections (HP:0005406)1.84448627
109Hepatocellular carcinoma (HP:0001402)1.84256751
110Rough bone trabeculation (HP:0100670)1.84025694
111Amyloidosis (HP:0011034)1.83780040
112Trismus (HP:0000211)1.83686431
113Premature rupture of membranes (HP:0001788)1.83156953
114Abnormality of polysaccharide metabolism (HP:0011012)1.83085264
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83085264
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83085264
117Stridor (HP:0010307)1.82761436
118Diminished motivation (HP:0000745)1.81733201
119Increased muscle lipid content (HP:0009058)1.81601340
120Glomerulonephritis (HP:0000099)1.81360737
121Paralysis (HP:0003470)1.80936123
122Ketosis (HP:0001946)1.80873537
123Hypertriglyceridemia (HP:0002155)1.80661843
124Exercise-induced myalgia (HP:0003738)1.80538314
125Abnormality of the gallbladder (HP:0005264)1.80405945
126Striae distensae (HP:0001065)1.79603603
127Genu recurvatum (HP:0002816)1.78125963
128Hypoglycemic coma (HP:0001325)1.77477696
129Abnormality of the common coagulation pathway (HP:0010990)1.76767247
130Microcytic anemia (HP:0001935)1.76722195
131Gastrointestinal inflammation (HP:0004386)1.76216842
132Muscle stiffness (HP:0003552)1.75504211
133Polygenic inheritance (HP:0010982)1.75311877
134Nonimmune hydrops fetalis (HP:0001790)1.75068197
135Acute hepatic failure (HP:0006554)1.74464219
136Cutaneous melanoma (HP:0012056)1.74303352
137Increased intramyocellular lipid droplets (HP:0012240)1.73850838
138Apathy (HP:0000741)1.72308357
139Fragile nails (HP:0001808)1.72007195
140Malnutrition (HP:0004395)1.71683980
141Recurrent fungal infections (HP:0002841)1.70654773
142Microvesicular hepatic steatosis (HP:0001414)1.70373840
143Broad distal phalanx of finger (HP:0009836)1.69678706
144Hyperacusis (HP:0010780)1.69531656
145Mediastinal lymphadenopathy (HP:0100721)1.69061024
146Fasciculations (HP:0002380)1.68214488
147Cerebral palsy (HP:0100021)1.68020019
148Lower limb hyperreflexia (HP:0002395)1.67956388
149Ketoacidosis (HP:0001993)1.67855227
150Growth hormone excess (HP:0000845)1.67303701
151Seborrheic dermatitis (HP:0001051)1.67123164
152Nuclear cataract (HP:0100018)1.66800887
153Erythema (HP:0010783)1.66300326
154Bulbar palsy (HP:0001283)1.65784365
155Abnormality of the motor neurons (HP:0002450)1.65617332
156Abnormal neuron morphology (HP:0012757)1.65617332
157Mutism (HP:0002300)1.65123556
158Asymmetric septal hypertrophy (HP:0001670)1.64843142
159Difficulty climbing stairs (HP:0003551)1.64261290
160Hypokinesia (HP:0002375)1.64047761
161Delusions (HP:0000746)1.61974011
162Neurofibrillary tangles (HP:0002185)1.60736243
163Hemorrhage of the eye (HP:0011885)1.59287970
164Myoglobinuria (HP:0002913)1.58854329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.27000047
2ERN14.11024030
3MAP3K103.42327436
4PKN22.64401749
5PRPF4B2.48503044
6SMG12.25055385
7VRK22.21355691
8TBK12.18123087
9KSR22.17261740
10GRK62.12440569
11CDK192.08282487
12PIM22.00769497
13TESK11.98163471
14ARAF1.94169111
15TAOK21.92439553
16TESK21.90093864
17MAP3K111.84384719
18FGFR41.83340217
19IRAK31.79943548
20BLK1.79842277
21MAP4K11.68727439
22TAOK11.65222968
23EPHB21.64366986
24RIPK41.63595473
25NME21.49433394
26EPHA21.48772881
27MAP2K21.33934680
28KDR1.28633853
29MAP3K11.25662973
30LIMK11.22876039
31BMX1.22810939
32EEF2K1.22289599
33DAPK21.22130295
34IKBKE1.21845189
35TYK21.21323055
36MAP3K31.20297917
37ZAP701.17925830
38ABL21.15718427
39DAPK31.15018729
40DYRK1B1.14044240
41EPHA31.11088423
42MAP3K21.08355144
43LRRK21.07889323
44JAK21.05047065
45RIPK11.03654465
46EPHB11.02938674
47BCKDK1.02866538
48IRAK41.01705471
49JAK31.01050254
50PTK61.01041946
51SCYL21.00555731
52MAP3K90.96636995
53MST1R0.94333136
54KSR10.92011802
55CSK0.90775701
56SIK10.89961517
57TNK20.89568521
58SIK20.88675650
59FES0.87976313
60MAPKAPK30.83236458
61MATK0.82716472
62MAP2K10.81260952
63NTRK10.81144605
64SYK0.79591688
65PRKD30.79564696
66ALK0.78564431
67RET0.76307365
68RAF10.76051771
69MAPK110.75032008
70HIPK20.73689787
71JAK10.73599718
72PRKG20.73392001
73PRKD20.73311859
74LMTK20.71288946
75PAK60.70647664
76GRK50.70077188
77MAP3K130.69245211
78ICK0.69196780
79CAMKK10.68657393
80PDGFRA0.65802283
81DAPK10.65279015
82DMPK0.63365670
83PTK20.63364914
84IKBKB0.63039532
85TGFBR20.62741531
86CSNK1G30.61659433
87IRAK20.60541072
88PIM10.60029662
89ILK0.59648629
90PAK40.58973258
91PAK10.58955000
92BRAF0.57741682
93FGFR30.57089085
94MAP3K120.56108978
95UHMK10.55918435
96CDK140.54496085
97AURKA0.54446824
98LATS20.53974427
99CDK11A0.53867212
100CAMK2G0.52007370
101STK100.51538855
102FLT30.50632663
103MINK10.50349713
104EPHA40.50305745
105MAPK150.50041977
106DDR20.47956240
107MAP3K60.47922594
108CDK150.47566667
109MAP3K80.47535063
110PDPK10.47214218
111FER0.46855642
112HCK0.45174262
113CDK180.44891970
114PRKCH0.44770335
115MUSK0.44374814
116MAP2K30.44053064
117MAP3K140.43199897
118RPS6KA10.41990528
119CSF1R0.41555980
120MAPKAPK20.40999109
121CCNB10.40963914
122BUB10.40744878
123DYRK30.39453061
124FGR0.38863758
125BTK0.38789947
126MOS0.38463142
127PTK2B0.38382793
128MARK20.38294845
129SIK30.37701314
130RPS6KC10.37080349
131RPS6KA40.35816741
132LYN0.34303318
133RPS6KA20.32902967

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.43507558
2Pentose phosphate pathway_Homo sapiens_hsa000302.61347850
3Vibrio cholerae infection_Homo sapiens_hsa051102.32614672
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29877474
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28097155
6Fructose and mannose metabolism_Homo sapiens_hsa000512.26807364
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.17262799
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15539948
9Synaptic vesicle cycle_Homo sapiens_hsa047211.92924127
10Biosynthesis of amino acids_Homo sapiens_hsa012301.92881402
11Staphylococcus aureus infection_Homo sapiens_hsa051501.92518529
12Bladder cancer_Homo sapiens_hsa052191.91512400
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.90861792
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87920134
15Leishmaniasis_Homo sapiens_hsa051401.84564222
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84123238
17Proteasome_Homo sapiens_hsa030501.82974032
18Base excision repair_Homo sapiens_hsa034101.72561482
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64348585
20Fatty acid elongation_Homo sapiens_hsa000621.59550140
21VEGF signaling pathway_Homo sapiens_hsa043701.53658680
22Carbon metabolism_Homo sapiens_hsa012001.53542223
23Primary immunodeficiency_Homo sapiens_hsa053401.52453196
24Collecting duct acid secretion_Homo sapiens_hsa049661.47439864
25Acute myeloid leukemia_Homo sapiens_hsa052211.47092351
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42590040
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.42402634
28Prion diseases_Homo sapiens_hsa050201.41452050
29Chronic myeloid leukemia_Homo sapiens_hsa052201.38701920
30Osteoclast differentiation_Homo sapiens_hsa043801.38588350
31Arginine biosynthesis_Homo sapiens_hsa002201.36202185
32Complement and coagulation cascades_Homo sapiens_hsa046101.33827952
33Pertussis_Homo sapiens_hsa051331.32022861
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30691511
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.29193387
36Glutathione metabolism_Homo sapiens_hsa004801.25940791
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25286389
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24769819
39Fat digestion and absorption_Homo sapiens_hsa049751.24121601
40DNA replication_Homo sapiens_hsa030301.17053751
41Salmonella infection_Homo sapiens_hsa051321.14399887
42Phagosome_Homo sapiens_hsa041451.12244420
43* Endocytosis_Homo sapiens_hsa041441.11567933
44Tryptophan metabolism_Homo sapiens_hsa003801.10852364
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10825441
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10649293
47Non-small cell lung cancer_Homo sapiens_hsa052231.10200254
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07405232
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05691638
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03975061
51Folate biosynthesis_Homo sapiens_hsa007901.03376685
52Pancreatic cancer_Homo sapiens_hsa052121.02744532
53Oxidative phosphorylation_Homo sapiens_hsa001901.02655761
54Tuberculosis_Homo sapiens_hsa051521.02231890
55Bile secretion_Homo sapiens_hsa049760.99414870
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99127489
57Shigellosis_Homo sapiens_hsa051310.97474258
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97425682
59Apoptosis_Homo sapiens_hsa042100.97297305
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95940916
61B cell receptor signaling pathway_Homo sapiens_hsa046620.95834186
62Toxoplasmosis_Homo sapiens_hsa051450.94446078
63Prolactin signaling pathway_Homo sapiens_hsa049170.94290356
64Galactose metabolism_Homo sapiens_hsa000520.94247655
65Sulfur metabolism_Homo sapiens_hsa009200.93986493
66TNF signaling pathway_Homo sapiens_hsa046680.93259563
67Viral myocarditis_Homo sapiens_hsa054160.92160863
68Legionellosis_Homo sapiens_hsa051340.91449831
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.90906256
70Parkinsons disease_Homo sapiens_hsa050120.90838109
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90478277
72Glioma_Homo sapiens_hsa052140.90019021
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.85742910
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84671379
75Rheumatoid arthritis_Homo sapiens_hsa053230.84589157
76Starch and sucrose metabolism_Homo sapiens_hsa005000.84288814
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83999059
78Thyroid cancer_Homo sapiens_hsa052160.83522926
79T cell receptor signaling pathway_Homo sapiens_hsa046600.83141059
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.83054488
81Autoimmune thyroid disease_Homo sapiens_hsa053200.82447218
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79852113
83Phenylalanine metabolism_Homo sapiens_hsa003600.78887460
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.78732151
85beta-Alanine metabolism_Homo sapiens_hsa004100.78480412
86Measles_Homo sapiens_hsa051620.78447469
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77803779
88Hepatitis B_Homo sapiens_hsa051610.77469970
89Fatty acid degradation_Homo sapiens_hsa000710.76035694
90Caffeine metabolism_Homo sapiens_hsa002320.75785360
91Insulin resistance_Homo sapiens_hsa049310.74694156
92Pyrimidine metabolism_Homo sapiens_hsa002400.73331621
93Ribosome_Homo sapiens_hsa030100.72985844
94Histidine metabolism_Homo sapiens_hsa003400.71968278
95Endometrial cancer_Homo sapiens_hsa052130.71235472
96Malaria_Homo sapiens_hsa051440.71167606
97Lysosome_Homo sapiens_hsa041420.70437066
98Influenza A_Homo sapiens_hsa051640.70291904
99Herpes simplex infection_Homo sapiens_hsa051680.70289052
100Epstein-Barr virus infection_Homo sapiens_hsa051690.69719968
101Amoebiasis_Homo sapiens_hsa051460.69606487
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68998291
103Chemical carcinogenesis_Homo sapiens_hsa052040.68866993
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68625972
105Chemokine signaling pathway_Homo sapiens_hsa040620.66489025
106Graft-versus-host disease_Homo sapiens_hsa053320.66308332
107Hepatitis C_Homo sapiens_hsa051600.65132894
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65099065
109Notch signaling pathway_Homo sapiens_hsa043300.63476414
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.62177351
111Type I diabetes mellitus_Homo sapiens_hsa049400.61992323
112PPAR signaling pathway_Homo sapiens_hsa033200.61422764
113N-Glycan biosynthesis_Homo sapiens_hsa005100.60566336
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.60242701
115Insulin signaling pathway_Homo sapiens_hsa049100.57233927
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55932325
117Antigen processing and presentation_Homo sapiens_hsa046120.55195825
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54760668
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.52949059
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52323584
121Alzheimers disease_Homo sapiens_hsa050100.51147544
122Viral carcinogenesis_Homo sapiens_hsa052030.49419996
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48814297
124Nitrogen metabolism_Homo sapiens_hsa009100.48793494
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.48374887
126Other glycan degradation_Homo sapiens_hsa005110.47977779
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.47938892
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47858660
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47320187
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.47218623
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46625666
132ABC transporters_Homo sapiens_hsa020100.46444149
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46059894
134African trypanosomiasis_Homo sapiens_hsa051430.44900787
135HIF-1 signaling pathway_Homo sapiens_hsa040660.44460553
136Arginine and proline metabolism_Homo sapiens_hsa003300.43678347
137Platelet activation_Homo sapiens_hsa046110.42282804
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42098535
139Allograft rejection_Homo sapiens_hsa053300.40128670
140Type II diabetes mellitus_Homo sapiens_hsa049300.39700681
141HTLV-I infection_Homo sapiens_hsa051660.36875779
142Hematopoietic cell lineage_Homo sapiens_hsa046400.36072618

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