ARF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.28666877
2proteasome assembly (GO:0043248)4.96477137
3DNA double-strand break processing (GO:0000729)4.55850740
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.53850335
5cytidine deamination (GO:0009972)4.23828921
6cytidine metabolic process (GO:0046087)4.23828921
7cytidine catabolic process (GO:0006216)4.23828921
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.15719600
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15719600
10antigen processing and presentation of endogenous antigen (GO:0019883)3.92189810
11keratinocyte development (GO:0003334)3.88732232
12positive regulation of gamma-delta T cell activation (GO:0046645)3.87256563
13negative regulation of DNA-dependent DNA replication (GO:2000104)3.84613287
14pyrimidine ribonucleoside catabolic process (GO:0046133)3.63912769
15lactate metabolic process (GO:0006089)3.61072712
16positive regulation of protein autophosphorylation (GO:0031954)3.59579962
17replication fork processing (GO:0031297)3.52499409
18signal peptide processing (GO:0006465)3.48497340
19somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.46919570
20somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.46919570
21isotype switching (GO:0045190)3.46919570
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46709096
23cullin deneddylation (GO:0010388)3.43445399
24positive regulation of glycoprotein biosynthetic process (GO:0010560)3.39519293
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39382665
26positive thymic T cell selection (GO:0045059)3.38516206
27protein K6-linked ubiquitination (GO:0085020)3.36107380
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35623451
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35332713
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35332713
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35332713
32regulation of gamma-delta T cell differentiation (GO:0045586)3.34970118
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31571169
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31571169
35regulation of DNA endoreduplication (GO:0032875)3.30136943
36DNA catabolic process, exonucleolytic (GO:0000738)3.30108888
37viral transcription (GO:0019083)3.27527261
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25602981
39regulation of cellular amino acid metabolic process (GO:0006521)3.24974714
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18438032
41protein deneddylation (GO:0000338)3.18151049
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17522811
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.17522811
44mitotic sister chromatid cohesion (GO:0007064)3.16466774
45translational termination (GO:0006415)3.16460028
46response to X-ray (GO:0010165)3.15208171
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.14303939
48melanin biosynthetic process (GO:0042438)3.12658199
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.12063440
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08334766
51ribosome assembly (GO:0042255)3.07881357
52regulation of gamma-delta T cell activation (GO:0046643)3.06959480
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05926952
54positive regulation of glycoprotein metabolic process (GO:1903020)3.05481876
55negative regulation of ligase activity (GO:0051352)3.04925684
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04925684
57Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00270534
58attachment of spindle microtubules to kinetochore (GO:0008608)2.99395466
59melanin metabolic process (GO:0006582)2.98940018
60regulation of T cell chemotaxis (GO:0010819)2.96320567
61positive regulation of T cell chemotaxis (GO:0010820)2.96320567
62histone exchange (GO:0043486)2.93711084
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87207959
64thymic T cell selection (GO:0045061)2.85841256
65Rap protein signal transduction (GO:0032486)2.84088610
66CENP-A containing nucleosome assembly (GO:0034080)2.83151694
67establishment of chromosome localization (GO:0051303)2.83134526
68nuclear pore complex assembly (GO:0051292)2.82344452
69chromatin remodeling at centromere (GO:0031055)2.81356466
70platelet dense granule organization (GO:0060155)2.81223970
71secondary metabolite biosynthetic process (GO:0044550)2.80525155
72respiratory chain complex IV assembly (GO:0008535)2.80022277
73mitotic metaphase plate congression (GO:0007080)2.78268029
74negative regulation of thymocyte apoptotic process (GO:0070244)2.78223809
75germ cell migration (GO:0008354)2.75810020
76regulation of protein autophosphorylation (GO:0031952)2.74571927
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74004866
78metaphase plate congression (GO:0051310)2.73024170
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72982042
80regulation of mitotic spindle checkpoint (GO:1903504)2.72982042
81negative T cell selection (GO:0043383)2.71641328
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71574783
83negative regulation of protein autophosphorylation (GO:0031953)2.69993389
84negative thymic T cell selection (GO:0045060)2.69991613
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69785995
86synapsis (GO:0007129)2.69488550
87regulation of translational termination (GO:0006449)2.67812724
88spindle checkpoint (GO:0031577)2.65905203
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.65149758
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64385870
91regulation of centriole replication (GO:0046599)2.64232687
92positive regulation of cell cycle arrest (GO:0071158)2.63511149
93negative regulation of phagocytosis (GO:0050765)2.63272808
94mitotic G2 DNA damage checkpoint (GO:0007095)2.62056345
95rRNA methylation (GO:0031167)2.60760806
96mitotic sister chromatid segregation (GO:0000070)2.60085353
97mitotic nuclear envelope disassembly (GO:0007077)2.58577571
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.57344856
99regulation of B cell receptor signaling pathway (GO:0050855)2.56801261
100translational elongation (GO:0006414)2.56411398
101positive regulation of ligase activity (GO:0051351)2.56139551
102ribosomal small subunit biogenesis (GO:0042274)2.55739274
103developmental pigmentation (GO:0048066)2.55336427
104ribosomal small subunit assembly (GO:0000028)2.54763489
105telomere maintenance via telomerase (GO:0007004)2.54582315
106leukocyte aggregation (GO:0070486)2.54280505
107skin morphogenesis (GO:0043589)2.53179666
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.53021794
109positive T cell selection (GO:0043368)2.52912707
110mitotic G2/M transition checkpoint (GO:0044818)2.52778070
111interferon-gamma secretion (GO:0072643)2.52685982
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.52650203
113JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52533772
114interferon-gamma production (GO:0032609)2.52280476
115nuclear pore organization (GO:0006999)2.52096997
116viral life cycle (GO:0019058)2.51828045
117negative regulation of signal transduction by p53 class mediator (GO:1901797)2.51060789
118pinocytosis (GO:0006907)2.50961524
119* hepatocyte apoptotic process (GO:0097284)2.50819097
120embryonic process involved in female pregnancy (GO:0060136)2.50149338
121tolerance induction (GO:0002507)2.49939122
122response to laminar fluid shear stress (GO:0034616)2.49779846
123T cell selection (GO:0045058)2.49315148
124negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.49028978
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.47830956
126mitotic spindle checkpoint (GO:0071174)2.47365039
127histone mRNA catabolic process (GO:0071044)2.46754886
128regulation of ligase activity (GO:0051340)2.46185375
129sister chromatid segregation (GO:0000819)2.45252380
130negative regulation of cell killing (GO:0031342)2.45215958
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45215958
132positive regulation by symbiont of host defense response (GO:0052509)2.44397524
133modulation by symbiont of host defense response (GO:0052031)2.44397524
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44397524
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44397524
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.44397524
137modulation by symbiont of host immune response (GO:0052553)2.44397524
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44268801
139positive regulation of defense response to virus by host (GO:0002230)2.43880822
140kinetochore organization (GO:0051383)2.43619417
141negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.43585941
142protein targeting to ER (GO:0045047)2.43448033
143postreplication repair (GO:0006301)2.42933763
144recombinational repair (GO:0000725)2.42836420
145rRNA modification (GO:0000154)2.41883985
146positive regulation of interferon-alpha production (GO:0032727)2.41381149
147negative regulation of protein ubiquitination (GO:0031397)2.40940470
148double-strand break repair via homologous recombination (GO:0000724)2.40766973
149immunoglobulin mediated immune response (GO:0016064)2.40722045
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40600458
151cotranslational protein targeting to membrane (GO:0006613)2.38101578
152regulation of interferon-beta biosynthetic process (GO:0045357)2.36727982
153regulation of interferon-alpha production (GO:0032647)2.36035453
154negative regulation of B cell proliferation (GO:0030889)2.35402319
155establishment of protein localization to endoplasmic reticulum (GO:0072599)2.33935114
156RNA stabilization (GO:0043489)2.33133107
157mRNA stabilization (GO:0048255)2.33133107
158NIK/NF-kappaB signaling (GO:0038061)2.32245868
159positive regulation of natural killer cell differentiation (GO:0032825)2.31492669
160establishment of endothelial barrier (GO:0061028)2.31413089
161cellular protein complex disassembly (GO:0043624)2.31101320
162regulation of T cell tolerance induction (GO:0002664)2.30617651
163hemidesmosome assembly (GO:0031581)2.30555972
164translational initiation (GO:0006413)2.30505993
165response to interleukin-15 (GO:0070672)2.29614913
166positive regulation of B cell differentiation (GO:0045579)2.28767794
167myeloid dendritic cell activation (GO:0001773)2.28016927
168T cell costimulation (GO:0031295)2.27837774
1693-UTR-mediated mRNA stabilization (GO:0070935)2.27454613
170definitive hemopoiesis (GO:0060216)2.25062053
171positive regulation of isotype switching (GO:0045830)2.24910138
172pore complex assembly (GO:0046931)2.22958097
173B cell mediated immunity (GO:0019724)2.22606144
174leukocyte cell-cell adhesion (GO:0007159)2.22018802
175lymphocyte costimulation (GO:0031294)2.21153909
176B cell receptor signaling pathway (GO:0050853)2.20626709
177T cell migration (GO:0072678)2.20250333
178positive regulation of histone deacetylation (GO:0031065)2.20226848
179protein localization to endoplasmic reticulum (GO:0070972)2.19571058
180actin nucleation (GO:0045010)2.19384361
181maturation of SSU-rRNA (GO:0030490)2.19129677
182regulation of B cell differentiation (GO:0045577)2.18605333
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.16921383
184regulation of response to interferon-gamma (GO:0060330)2.16766311
185dosage compensation (GO:0007549)2.16667444
186T cell apoptotic process (GO:0070231)2.16529928
187trophectodermal cell differentiation (GO:0001829)2.16135785
188regulation of type I interferon-mediated signaling pathway (GO:0060338)2.14614341
189regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.14337685
190interferon-gamma-mediated signaling pathway (GO:0060333)2.14205592
191endothelial tube morphogenesis (GO:0061154)2.12739133
192morphogenesis of an endothelium (GO:0003159)2.12739133
193response to muramyl dipeptide (GO:0032495)2.12371861
194natural killer cell differentiation (GO:0001779)2.11428023
195cell adhesion mediated by integrin (GO:0033627)2.11227483
196neutrophil activation involved in immune response (GO:0002283)2.10847749
197regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.09958179
198regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.09319904
199myeloid dendritic cell differentiation (GO:0043011)2.08980289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.27620556
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.61422555
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07555541
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.87573050
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50621335
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48301571
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.97348046
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96922332
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.95564401
10* FOXM1_23109430_ChIP-Seq_U2OS_Human2.95336163
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.91357188
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.81922824
13MYC_22102868_ChIP-Seq_BL_Human2.75509794
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49077667
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45271807
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.44917045
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40616653
18* EST1_17652178_ChIP-ChIP_JURKAT_Human2.32974795
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24176568
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12434951
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.09429798
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07611834
23VDR_21846776_ChIP-Seq_THP-1_Human2.06651619
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04747611
25MAF_26560356_Chip-Seq_TH1_Human2.04106882
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03376055
27VDR_22108803_ChIP-Seq_LS180_Human2.01407903
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98059349
29VDR_23849224_ChIP-Seq_CD4+_Human1.97158322
30MYB_26560356_Chip-Seq_TH2_Human1.95832814
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.90706364
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88638464
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88558741
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87405689
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86634664
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85182104
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84214893
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83279417
39MYB_26560356_Chip-Seq_TH1_Human1.80266569
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79527749
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79075026
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79055490
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.78018100
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77431636
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76029124
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75810433
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75142243
48UTX_26944678_Chip-Seq_JUKART_Human1.74912667
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67566290
50FOXP3_21729870_ChIP-Seq_TREG_Human1.66053212
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.62570957
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60903563
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60340569
54* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60179693
55* EWS_26573619_Chip-Seq_HEK293_Human1.58730294
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57962777
57RUNX_20019798_ChIP-Seq_JUKART_Human1.57584604
58VDR_24763502_ChIP-Seq_THP-1_Human1.57070114
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53785305
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52552762
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51057155
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50159301
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49793557
64ZNF274_21170338_ChIP-Seq_K562_Hela1.49544222
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.49333362
66CLOCK_20551151_ChIP-Seq_293T_Human1.49282432
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.47684327
68* SPI1_23547873_ChIP-Seq_NB4_Human1.46856416
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46845801
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46640445
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46624747
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46385577
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46385577
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44089287
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.43568900
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43355028
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43181019
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41827657
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40502491
80* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39404538
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.36752584
82KDM2B_26808549_Chip-Seq_DND41_Human1.32553842
83P300_19829295_ChIP-Seq_ESCs_Human1.31197572
84* FOXO3_23340844_ChIP-Seq_DLD1_Human1.28765858
85FUS_26573619_Chip-Seq_HEK293_Human1.27768873
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27684932
87AR_21909140_ChIP-Seq_LNCAP_Human1.26484833
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.24624627
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24104116
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.23131438
91MAF_26560356_Chip-Seq_TH2_Human1.22986573
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.22871049
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22789600
94ATF3_27146783_Chip-Seq_COLON_Human1.20846819
95GATA3_26560356_Chip-Seq_TH2_Human1.20460170
96* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19624417
97SCL_19346495_ChIP-Seq_HPC-7_Human1.19334036
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18195466
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17987233
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17727554
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17112947
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.16416844
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16273424
104* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15831034
105BRD4_25478319_ChIP-Seq_HGPS_Human1.15587502
106* PU_27001747_Chip-Seq_BMDM_Mouse1.14122277
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14095306
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13956402
109* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12906874
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12272899
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12212227
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.11898191
113MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11855267
114* GATA6_25053715_ChIP-Seq_YYC3_Human1.11720134
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.11200096
116CDX2_22108803_ChIP-Seq_LS180_Human1.10359941
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09914828
118ER_23166858_ChIP-Seq_MCF-7_Human1.09830073
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08972217
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08940012
121NCOR1_26117541_ChIP-Seq_K562_Human1.08871461
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08825972
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06728320
124MYC_18940864_ChIP-ChIP_HL60_Human1.05608914
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05080050
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04030111
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.03986107
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03321348
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02723309
130ZNF263_19887448_ChIP-Seq_K562_Human1.02612629
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01010897
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99680891
133GATA3_27048872_Chip-Seq_THYMUS_Human0.99441117
134* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98496728
135SALL4_22934838_ChIP-ChIP_CD34+_Human0.98042659
136ETS1_20019798_ChIP-Seq_JURKAT_Human0.97563874
137EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97530362
138P300_18555785_Chip-Seq_ESCs_Mouse0.95951958
139* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95369588
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95184804
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94469062
142ELK1_19687146_ChIP-ChIP_HELA_Human0.94187371
143BCAT_22108803_ChIP-Seq_LS180_Human0.93927784
144RACK7_27058665_Chip-Seq_MCF-7_Human0.93568239
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92925699
146* ELF5_23300383_ChIP-Seq_T47D_Human0.92681461
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92526256
148* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92268779
149* SOX2_19829295_ChIP-Seq_ESCs_Human0.92175559
150* NANOG_19829295_ChIP-Seq_ESCs_Human0.92175559
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92076668
152* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91642392
153BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90229330
154P53_22387025_ChIP-Seq_ESCs_Mouse0.89807049
155CHD1_26751641_Chip-Seq_LNCaP_Human0.89782750
156RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89149920
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89036092
158RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88557703
159RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88004974
160TFEB_21752829_ChIP-Seq_HELA_Human0.87931148
161* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87621675
162STAT3_18555785_Chip-Seq_ESCs_Mouse0.87558175
163CMYC_18555785_Chip-Seq_ESCs_Mouse0.87262697
164OCT4_18555785_Chip-Seq_ESCs_Mouse0.86935428
165CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86529632
166TAF15_26573619_Chip-Seq_HEK293_Human0.86113660
167KDM2B_26808549_Chip-Seq_JURKAT_Human0.85997525
168SPI1_23127762_ChIP-Seq_K562_Human0.85418281
169NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84182226
170GATA1_22025678_ChIP-Seq_K562_Human0.83688947
171SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80839350
172GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80603368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.79459184
2MP0005075_abnormal_melanosome_morpholog3.39033141
3MP0008057_abnormal_DNA_replication3.18233795
4MP0010352_gastrointestinal_tract_polyps2.81098333
5MP0010234_abnormal_vibrissa_follicle2.73703035
6MP0003806_abnormal_nucleotide_metabolis2.70154009
7MP0003300_gastrointestinal_ulcer2.65554244
8MP0005408_hypopigmentation2.55301843
9MP0003950_abnormal_plasma_membrane2.48264800
10MP0003303_peritoneal_inflammation2.48112248
11MP0003705_abnormal_hypodermis_morpholog2.42193955
12MP0002102_abnormal_ear_morphology2.40898385
13MP0000015_abnormal_ear_pigmentation2.34800138
14MP0001835_abnormal_antigen_presentation2.30359732
15MP0003195_calcinosis2.24846664
16MP0003436_decreased_susceptibility_to2.23812829
17MP0002166_altered_tumor_susceptibility2.16220510
18MP0008058_abnormal_DNA_repair2.00006940
19MP0000685_abnormal_immune_system1.97825646
20MP0000371_diluted_coat_color1.94119496
21MP0003763_abnormal_thymus_physiology1.93897648
22MP0005076_abnormal_cell_differentiation1.93245852
23MP0004947_skin_inflammation1.93088894
24MP0003786_premature_aging1.93045077
25MP0001800_abnormal_humoral_immune1.92768847
26MP0001790_abnormal_immune_system1.83710540
27MP0005387_immune_system_phenotype1.83710540
28MP0003566_abnormal_cell_adhesion1.81680316
29MP0002006_tumorigenesis1.81456502
30MP0005671_abnormal_response_to1.79678218
31MP0005174_abnormal_tail_pigmentation1.79029092
32MP0000569_abnormal_digit_pigmentation1.75101049
33MP0002796_impaired_skin_barrier1.74927135
34MP0002452_abnormal_antigen_presenting1.74897693
35MP0005000_abnormal_immune_tolerance1.74281553
36MP0003453_abnormal_keratinocyte_physiol1.73367432
37MP0010155_abnormal_intestine_physiology1.68258376
38MP0010307_abnormal_tumor_latency1.67021957
39MP0002877_abnormal_melanocyte_morpholog1.64285792
40MP0002095_abnormal_skin_pigmentation1.63948580
41MP0005275_abnormal_skin_tensile1.62101253
42MP0000516_abnormal_urinary_system1.59615448
43MP0005367_renal/urinary_system_phenotyp1.59615448
44MP0002420_abnormal_adaptive_immunity1.59093935
45MP0001873_stomach_inflammation1.58689503
46MP0001819_abnormal_immune_cell1.57758186
47MP0002723_abnormal_immune_serum1.57488405
48MP0005025_abnormal_response_to1.54940544
49MP0002405_respiratory_system_inflammati1.54745056
50MP0009785_altered_susceptibility_to1.52695387
51MP0009333_abnormal_splenocyte_physiolog1.51411203
52MP0005171_absent_coat_pigmentation1.49917222
53MP0003448_altered_tumor_morphology1.49800953
54MP0002398_abnormal_bone_marrow1.49755123
55MP0006054_spinal_hemorrhage1.47934989
56MP0005023_abnormal_wound_healing1.47173220
57MP0000490_abnormal_crypts_of1.46985203
58MP0002396_abnormal_hematopoietic_system1.44335221
59MP0008438_abnormal_cutaneous_collagen1.41781881
60MP0004808_abnormal_hematopoietic_stem1.41713401
61MP0008877_abnormal_DNA_methylation1.40755580
62MP0000465_gastrointestinal_hemorrhage1.38151670
63MP0002148_abnormal_hypersensitivity_rea1.37519710
64MP0002060_abnormal_skin_morphology1.37405653
65MP0000858_altered_metastatic_potential1.36513035
66MP0002419_abnormal_innate_immunity1.35599920
67MP0000427_abnormal_hair_cycle1.34614922
68MP0001216_abnormal_epidermal_layer1.34287465
69MP0002009_preneoplasia1.34014274
70MP0005501_abnormal_skin_physiology1.33514782
71MP0009278_abnormal_bone_marrow1.32490197
72MP0000716_abnormal_immune_system1.30930597
73MP0003724_increased_susceptibility_to1.30061851
74MP0002722_abnormal_immune_system1.26722801
75MP0006082_CNS_inflammation1.26251566
76MP0000689_abnormal_spleen_morphology1.25999490
77MP0005464_abnormal_platelet_physiology1.25212033
78MP0001545_abnormal_hematopoietic_system1.18328377
79MP0005397_hematopoietic_system_phenotyp1.18328377
80MP0001533_abnormal_skeleton_physiology1.16872756
81MP0003718_maternal_effect1.16488539
82MP0001845_abnormal_inflammatory_respons1.16470848
83MP0000703_abnormal_thymus_morphology1.14069552
84MP0004957_abnormal_blastocyst_morpholog1.13988176
85* MP0002429_abnormal_blood_cell1.13412902
86MP0002138_abnormal_hepatobiliary_system1.12602122
87MP0003866_abnormal_defecation1.12482447
88MP0003091_abnormal_cell_migration1.11262730
89MP0010678_abnormal_skin_adnexa1.06061931
90MP0001853_heart_inflammation1.05519339
91MP0002933_joint_inflammation1.04619283
92MP0003693_abnormal_embryo_hatching1.04408347
93MP0000377_abnormal_hair_follicle1.04345106
94MP0005395_other_phenotype1.02998409
95MP0002168_other_aberrant_phenotype1.01978788
96MP0004185_abnormal_adipocyte_glucose1.00141687
97MP0001324_abnormal_eye_pigmentation0.98530531
98MP0002090_abnormal_vision0.97247562
99MP0002019_abnormal_tumor_incidence0.97163949
100MP0003077_abnormal_cell_cycle0.96565023
101MP0002254_reproductive_system_inflammat0.96023705
102MP0008932_abnormal_embryonic_tissue0.94738692
103MP0009053_abnormal_anal_canal0.92748513
104MP0008007_abnormal_cellular_replicative0.92596900
105MP0001243_abnormal_dermal_layer0.92594804
106MP0002098_abnormal_vibrissa_morphology0.91204142
107MP0003941_abnormal_skin_development0.90593929
108MP0001851_eye_inflammation0.89392194
109MP0000350_abnormal_cell_proliferation0.89368434
110MP0000383_abnormal_hair_follicle0.89178860
111MP0009931_abnormal_skin_appearance0.87532929
112MP0006036_abnormal_mitochondrial_physio0.86909772
113MP0004510_myositis0.86806124
114MP0000627_abnormal_mammary_gland0.85865621
115MP0002075_abnormal_coat/hair_pigmentati0.85428051
116MP0000733_abnormal_muscle_development0.84905141
117MP0002277_abnormal_respiratory_mucosa0.84355812
118MP0001958_emphysema0.83677165
119MP0002938_white_spotting0.83648946
120MP0001191_abnormal_skin_condition0.83601591
121MP0004782_abnormal_surfactant_physiolog0.83266393
122MP0002998_abnormal_bone_remodeling0.83257383
123MP0003191_abnormal_cellular_cholesterol0.82681930
124MP0001186_pigmentation_phenotype0.82410087
125MP0000647_abnormal_sebaceous_gland0.81590072
126MP0000477_abnormal_intestine_morphology0.81565182
127MP0010094_abnormal_chromosome_stability0.79876351
128MP0002086_abnormal_extraembryonic_tissu0.79520359
129MP0001119_abnormal_female_reproductive0.78731504
130MP0003111_abnormal_nucleus_morphology0.77639255
131MP0003828_pulmonary_edema0.75925824
132MP0000613_abnormal_salivary_gland0.74860483
133MP0002751_abnormal_autonomic_nervous0.74513405
134MP0004381_abnormal_hair_follicle0.72881146
135MP0005310_abnormal_salivary_gland0.71625535
136MP0008873_increased_physiological_sensi0.71600093
137MP0005390_skeleton_phenotype0.70768245
138MP0003186_abnormal_redox_activity0.66925065
139MP0002282_abnormal_trachea_morphology0.65967495
140MP0009697_abnormal_copulation0.58802368
141MP0001697_abnormal_embryo_size0.55896733

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.64955566
2Abnormality of chromosome stability (HP:0003220)3.15698829
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01955575
4Hypoplasia of the fovea (HP:0007750)2.99510529
5Aplasia/Hypoplasia of the fovea (HP:0008060)2.99510529
6IgG deficiency (HP:0004315)2.93089097
7Interstitial pulmonary disease (HP:0006530)2.86191704
8Recurrent fungal infections (HP:0002841)2.85489661
9Albinism (HP:0001022)2.85220222
10Recurrent viral infections (HP:0004429)2.82777469
11Pustule (HP:0200039)2.80891539
12Breast carcinoma (HP:0003002)2.80115610
13Hematochezia (HP:0002573)2.79147196
14Chromsome breakage (HP:0040012)2.79038563
15Hypoproteinemia (HP:0003075)2.78647886
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.78334052
17Osteolytic defects of the hand bones (HP:0009699)2.78334052
18Cellulitis (HP:0100658)2.76056254
19Increased IgE level (HP:0003212)2.75217999
20Aplasia/Hypoplasia of the macula (HP:0008059)2.74453410
21Ocular albinism (HP:0001107)2.73382896
22Abnormality of the preputium (HP:0100587)2.67090224
23Posterior subcapsular cataract (HP:0007787)2.65577662
24Neoplasm of the adrenal gland (HP:0100631)2.64333161
25T lymphocytopenia (HP:0005403)2.63334677
26Recurrent abscess formation (HP:0002722)2.63106595
27Abnormality of T cell number (HP:0011839)2.58293148
28Increased density of long bones (HP:0006392)2.57648466
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.57215991
30Patchy hypopigmentation of hair (HP:0011365)2.56602175
31Small intestinal stenosis (HP:0012848)2.52636522
32Duodenal stenosis (HP:0100867)2.52636522
33Abnormal platelet volume (HP:0011876)2.51349649
34Volvulus (HP:0002580)2.49329961
35Meckel diverticulum (HP:0002245)2.49323815
36Abnormal lung lobation (HP:0002101)2.49318796
37Recurrent bronchitis (HP:0002837)2.49166811
38Aplasia/Hypoplasia affecting the retina (HP:0008061)2.48995059
39Abnormality of the fovea (HP:0000493)2.48465761
40Myositis (HP:0100614)2.48114322
41Thrombocytosis (HP:0001894)2.47242113
42Chronic otitis media (HP:0000389)2.46386140
43Iris hypopigmentation (HP:0007730)2.44074804
44Sensory axonal neuropathy (HP:0003390)2.43801474
45Neoplasm of the adrenal cortex (HP:0100641)2.43294027
46Elevated erythrocyte sedimentation rate (HP:0003565)2.42861000
47Myocardial infarction (HP:0001658)2.42678441
48Tongue fasciculations (HP:0001308)2.41009644
49Subacute progressive viral hepatitis (HP:0006572)2.37943886
50Abnormality of the ileum (HP:0001549)2.37911120
51Increased mean platelet volume (HP:0011877)2.36163361
52White forelock (HP:0002211)2.35721147
53Abnormality of methionine metabolism (HP:0010901)2.35126855
54Ependymoma (HP:0002888)2.34526053
55Congenital stationary night blindness (HP:0007642)2.33534065
56Autoimmune thrombocytopenia (HP:0001973)2.33440687
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31694425
58Spontaneous hematomas (HP:0007420)2.30031060
59Hamartoma of the eye (HP:0010568)2.29854395
60Clubbing of toes (HP:0100760)2.29298861
61IgM deficiency (HP:0002850)2.27002105
62Recurrent bacterial skin infections (HP:0005406)2.26159433
63Abnormal auditory evoked potentials (HP:0006958)2.23496169
64Conjunctival hamartoma (HP:0100780)2.23233791
65Persistence of primary teeth (HP:0006335)2.22077186
66Verrucae (HP:0200043)2.20853381
67Papilloma (HP:0012740)2.20853381
68Abnormality of the duodenum (HP:0002246)2.19366305
69Rectal prolapse (HP:0002035)2.19042190
70Milia (HP:0001056)2.18673541
71Abnormality of T cells (HP:0002843)2.18153003
72Chronic diarrhea (HP:0002028)2.17949767
73Abnormality of the fingertips (HP:0001211)2.17678161
74Abnormality of the prostate (HP:0008775)2.16505572
75Premature rupture of membranes (HP:0001788)2.15712361
76Nasal polyposis (HP:0100582)2.14401701
77Arterial thrombosis (HP:0004420)2.13036935
78Generalized hypopigmentation (HP:0007513)2.11957557
79Peritonitis (HP:0002586)2.11115884
80Prostate neoplasm (HP:0100787)2.10562712
81Glioma (HP:0009733)2.09321783
82Osteomyelitis (HP:0002754)2.09067800
83Abnormality of eosinophils (HP:0001879)2.08833141
84Nephroblastoma (Wilms tumor) (HP:0002667)2.07975104
85Atrophic scars (HP:0001075)2.07857031
86Embryonal renal neoplasm (HP:0011794)2.06735002
87Inflammation of the large intestine (HP:0002037)2.06709112
88Periodontitis (HP:0000704)2.05674283
89Reticulocytopenia (HP:0001896)2.05171557
90Thick nail (HP:0001805)2.02931668
91Skin ulcer (HP:0200042)2.02378840
92Muscle fibrillation (HP:0010546)2.01791323
93Ulnar bowing (HP:0003031)2.00688017
94Cerebral aneurysm (HP:0004944)2.00484332
95Leukocytosis (HP:0001974)2.00259405
96Hypothermia (HP:0002045)1.99435231
97Orchitis (HP:0100796)1.99363720
98Pulmonary infiltrates (HP:0002113)1.99189838
99Vasculitis (HP:0002633)1.99108686
100Protrusio acetabuli (HP:0003179)1.99070043
101Ovarian neoplasm (HP:0100615)1.98962675
102Woolly hair (HP:0002224)1.98683765
103Gastrointestinal inflammation (HP:0004386)1.98653511
104Methylmalonic acidemia (HP:0002912)1.98642310
105Mediastinal lymphadenopathy (HP:0100721)1.98037005
106Eosinophilia (HP:0001880)1.96359496
107Mitral valve prolapse (HP:0001634)1.96006325
108Aortic aneurysm (HP:0004942)1.95859525
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.95151093
110Colitis (HP:0002583)1.94471817
111Meningitis (HP:0001287)1.94383353
112Aortic dissection (HP:0002647)1.93756494
113Abnormality of the nasal mucosa (HP:0000433)1.93368128
114Stomatitis (HP:0010280)1.92967467
115Sloping forehead (HP:0000340)1.92816564
116Abnormality of T cell physiology (HP:0011840)1.92537408
117IgA deficiency (HP:0002720)1.92323608
118Progressive inability to walk (HP:0002505)1.91765529
119Chronic obstructive pulmonary disease (HP:0006510)1.91221598
120Obstructive lung disease (HP:0006536)1.91221598
121Myelodysplasia (HP:0002863)1.89917907
122Spinal cord lesions (HP:0100561)1.88637763
123Syringomyelia (HP:0003396)1.88637763
124Gastrointestinal infarctions (HP:0005244)1.86181994
125Stillbirth (HP:0003826)1.85130836
126Recurrent gram-negative bacterial infections (HP:0005420)1.84588351
127Emphysema (HP:0002097)1.84488418
128Meningioma (HP:0002858)1.83853079
129Pancreatic islet-cell hyperplasia (HP:0004510)1.83638251
130Chronic mucocutaneous candidiasis (HP:0002728)1.83617225
131Recurrent cutaneous fungal infections (HP:0011370)1.83617225
132Viral hepatitis (HP:0006562)1.83083826
133Abnormality of macrophages (HP:0004311)1.82183909
134Combined immunodeficiency (HP:0005387)1.81504738
135Intestinal atresia (HP:0011100)1.81411481
136Erythroderma (HP:0001019)1.81232486
137Abnormality of cells of the lymphoid lineage (HP:0012140)1.78811419
138Autoimmune hemolytic anemia (HP:0001890)1.76741393
139Dilatation of the ascending aorta (HP:0005111)1.76121856
140Freckling (HP:0001480)1.75020308
141Lymphoma (HP:0002665)1.74767754
142Blepharitis (HP:0000498)1.74669394
143Lymphopenia (HP:0001888)1.74368324
144Horizontal nystagmus (HP:0000666)1.73847813
145Generalized hypopigmentation of hair (HP:0011358)1.73366366
146Abnormality of the astrocytes (HP:0100707)1.72932783
147Astrocytoma (HP:0009592)1.72932783
148Thyroiditis (HP:0100646)1.72822574
149Ascites (HP:0001541)1.72037894
150Congenital, generalized hypertrichosis (HP:0004540)1.71963516
151Hypophosphatemic rickets (HP:0004912)1.71937026
152Abnormal hemoglobin (HP:0011902)1.71892995
153Curly hair (HP:0002212)1.71558844
154Entropion (HP:0000621)1.70551796
155Abnormality of the distal phalanges of the toes (HP:0010182)1.70464766
156Genu recurvatum (HP:0002816)1.69786582
157Deviation of the thumb (HP:0009603)1.68905803
158Recurrent skin infections (HP:0001581)1.68569732
159Rhabdomyosarcoma (HP:0002859)1.68371396
160Panhypogammaglobulinemia (HP:0003139)1.67334133
161Aplastic anemia (HP:0001915)1.67118466
162Petechiae (HP:0000967)1.66617697
163Severe combined immunodeficiency (HP:0004430)1.66358241
164Abnormality of the vitamin B12 metabolism (HP:0004341)1.65857673
165Neoplasm of the colon (HP:0100273)1.65790000
166B lymphocytopenia (HP:0010976)1.65527836
167Abnormality of B cell number (HP:0010975)1.65527836
168Lip pit (HP:0100267)1.65523946
169Abnormality of the gastric mucosa (HP:0004295)1.64392045
170Cutaneous melanoma (HP:0012056)1.64346646
171Agammaglobulinemia (HP:0004432)1.64335162
172Retrobulbar optic neuritis (HP:0100654)1.63729582
173Optic neuritis (HP:0100653)1.63729582
174Methylmalonic aciduria (HP:0012120)1.63674650
175Gangrene (HP:0100758)1.63595585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.26834698
2EIF2AK33.57311860
3BUB13.38284899
4ACVR1B3.36956796
5SIK33.22225496
6MAP4K13.13285651
7WEE13.00031660
8MKNK22.89844823
9EIF2AK12.73625829
10STK102.69671423
11ERBB32.60594894
12EEF2K2.56967971
13MST42.36447611
14MAP3K102.34371965
15TRIB32.25350959
16PLK32.16934779
17PKN22.08959540
18LRRK22.07015492
19BMPR1B2.06212281
20JAK31.90911097
21MAP3K141.86654630
22BRSK21.79279240
23TSSK61.75879518
24TYK21.75873349
25RPS6KA41.71705939
26CDK121.69075546
27WNK31.64195409
28TNIK1.63072071
29TXK1.62167919
30FGFR31.62158227
31MKNK11.62058703
32NEK11.61028776
33ERN11.60415819
34GRK61.58507903
35TBK11.58113268
36BCR1.52170494
37MAP3K31.50222811
38NME21.49653557
39PLK21.47954209
40CSK1.47851990
41FGFR41.47593081
42ZAP701.47337324
43PLK41.45503948
44PIM11.43175224
45MAP3K121.42611100
46TAF11.41277266
47CDK61.40488008
48PTK61.39998988
49EIF2AK21.39158943
50FRK1.37722823
51STK31.36058740
52ITK1.31445643
53TTK1.31297128
54ZAK1.31132485
55JAK11.30906265
56TGFBR21.30246911
57IKBKE1.29076142
58VRK21.28060418
59SRPK11.27956996
60NEK91.27135385
61TRPM71.25801397
62LATS11.24371318
63IKBKB1.24188607
64EPHB11.24083281
65RPS6KB21.23513617
66MST1R1.20708041
67TTN1.18177933
68EPHA21.17215794
69BLK1.14522736
70NLK1.12009862
71STK391.10383534
72CHUK1.09197563
73MAP2K31.09003741
74MAP3K81.06463184
75BMX1.05765870
76GRK11.03656173
77EPHA31.03349451
78FER1.03087027
79PDK21.03070370
80SCYL20.99199015
81STK40.98769617
82TLK10.98638023
83NEK20.97652908
84TEC0.95972727
85HCK0.95483232
86BTK0.95336310
87ALK0.94024412
88LCK0.93190744
89OXSR10.92479272
90CDK40.92299487
91PAK40.90273483
92IRAK40.89862798
93CSF1R0.87038047
94RIPK10.86534138
95BMPR20.83815855
96STK38L0.83233310
97KIT0.82883788
98PLK10.81919966
99VRK10.81303922
100TESK20.79990490
101CDK90.77499381
102IRAK30.76609453
103CLK10.76086709
104TGFBR10.75934321
105MARK30.74688706
106PIM20.73830301
107STK240.73824352
108MELK0.73341753
109JAK20.72652347
110CDC70.72217468
111PDGFRB0.72147506
112SYK0.66099403
113DMPK0.65803697
114NUAK10.65687312
115MAP3K110.61301009
116AURKB0.60968948
117MAP2K20.59529557
118SIK10.59439557
119MAPKAPK30.59361550
120TESK10.55976274
121PBK0.55701190
122PDGFRA0.55502673
123DYRK1B0.53537068
124MAPKAPK20.52797956
125BRSK10.52273518
126PAK30.51653605
127LIMK10.51038987
128FLT30.50381962
129FGFR20.50341645
130MAPK130.50199500
131TIE10.50122857
132KDR0.49003157
133ABL10.48863595
134PAK20.48369260
135LYN0.48064667
136EGFR0.47346664
137RPS6KA50.47100017
138ADRBK20.46867728
139PRKCI0.46436890
140ATR0.45478275
141GSK3A0.43433666
142STK160.43136166
143ATM0.42920470
144CSNK1G10.41969685
145HIPK20.41900054
146IGF1R0.41762414
147ILK0.41352215
148MUSK0.41185180
149TAOK10.40322443
150MAP3K20.39864440
151PRKCQ0.39767090
152PRKCE0.39393381
153MAP4K20.38723183
154FGFR10.38172553
155ERBB40.36564334
156GRK50.35822023
157PTK2B0.35750982
158DAPK10.33381228
159CSNK1G30.32864201
160FGR0.32165739
161CHEK20.30619755
162YES10.30356349
163PRKCH0.29566863
164MYLK0.27269010
165CSNK2A10.24195185
166CSNK1A1L0.24062862

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.11005001
2Non-homologous end-joining_Homo sapiens_hsa034503.72602764
3Protein export_Homo sapiens_hsa030603.40072679
4Homologous recombination_Homo sapiens_hsa034402.48512626
5Primary immunodeficiency_Homo sapiens_hsa053402.20936472
6Antigen processing and presentation_Homo sapiens_hsa046122.11878672
7Leishmaniasis_Homo sapiens_hsa051402.11799279
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.04277797
9Fanconi anemia pathway_Homo sapiens_hsa034601.93387740
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86791791
11Basal transcription factors_Homo sapiens_hsa030221.86320807
12B cell receptor signaling pathway_Homo sapiens_hsa046621.84213732
13Osteoclast differentiation_Homo sapiens_hsa043801.81864377
14Measles_Homo sapiens_hsa051621.80418776
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79586573
16Propanoate metabolism_Homo sapiens_hsa006401.77858609
17RNA degradation_Homo sapiens_hsa030181.77271421
18Small cell lung cancer_Homo sapiens_hsa052221.67826637
19Toxoplasmosis_Homo sapiens_hsa051451.66387979
20Graft-versus-host disease_Homo sapiens_hsa053321.64771736
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61686677
22T cell receptor signaling pathway_Homo sapiens_hsa046601.59594322
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.57415523
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.56505106
25Chronic myeloid leukemia_Homo sapiens_hsa052201.56027344
26Ribosome_Homo sapiens_hsa030101.55388022
27Hematopoietic cell lineage_Homo sapiens_hsa046401.53345919
28Herpes simplex infection_Homo sapiens_hsa051681.48947810
29Apoptosis_Homo sapiens_hsa042101.47785987
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44585342
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41086934
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.40448401
33Type I diabetes mellitus_Homo sapiens_hsa049401.39515874
34Legionellosis_Homo sapiens_hsa051341.39416661
35Viral carcinogenesis_Homo sapiens_hsa052031.38229440
36Nucleotide excision repair_Homo sapiens_hsa034201.36344544
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36189946
38Viral myocarditis_Homo sapiens_hsa054161.36099447
39Allograft rejection_Homo sapiens_hsa053301.35976548
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34580376
41RNA polymerase_Homo sapiens_hsa030201.33881402
42TNF signaling pathway_Homo sapiens_hsa046681.33746528
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33670651
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32518543
45Hepatitis B_Homo sapiens_hsa051611.32503281
46Malaria_Homo sapiens_hsa051441.31746845
47Acute myeloid leukemia_Homo sapiens_hsa052211.31222632
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30163065
49Shigellosis_Homo sapiens_hsa051311.29405436
50MicroRNAs in cancer_Homo sapiens_hsa052061.28804208
51Pancreatic cancer_Homo sapiens_hsa052121.28633587
52p53 signaling pathway_Homo sapiens_hsa041151.28154326
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26545147
54Adherens junction_Homo sapiens_hsa045201.26169557
55Fatty acid elongation_Homo sapiens_hsa000621.24795419
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22585080
57Influenza A_Homo sapiens_hsa051641.21880741
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20580395
59Pertussis_Homo sapiens_hsa051331.20043989
60Systemic lupus erythematosus_Homo sapiens_hsa053221.18149483
61* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17629252
62Vitamin B6 metabolism_Homo sapiens_hsa007501.16403607
63Sulfur metabolism_Homo sapiens_hsa009201.16270585
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15534277
65HTLV-I infection_Homo sapiens_hsa051661.14063469
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11005758
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09438935
68Staphylococcus aureus infection_Homo sapiens_hsa051501.08470210
69Tuberculosis_Homo sapiens_hsa051521.08168985
70Proteoglycans in cancer_Homo sapiens_hsa052051.05108704
71Salmonella infection_Homo sapiens_hsa051321.00561651
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99616195
73Hepatitis C_Homo sapiens_hsa051600.97640404
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97451349
75Platelet activation_Homo sapiens_hsa046110.97290538
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97243443
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.96678205
78Focal adhesion_Homo sapiens_hsa045100.96666264
79Prostate cancer_Homo sapiens_hsa052150.95042681
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94025030
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93458173
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91621305
83One carbon pool by folate_Homo sapiens_hsa006700.90812644
84DNA replication_Homo sapiens_hsa030300.90712078
85Thyroid cancer_Homo sapiens_hsa052160.90192965
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89400043
87Epstein-Barr virus infection_Homo sapiens_hsa051690.89312136
88Amoebiasis_Homo sapiens_hsa051460.88900977
89Chemokine signaling pathway_Homo sapiens_hsa040620.88328805
90Rheumatoid arthritis_Homo sapiens_hsa053230.88095332
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87802558
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87677977
93Bladder cancer_Homo sapiens_hsa052190.87203010
94ECM-receptor interaction_Homo sapiens_hsa045120.87142860
95Prolactin signaling pathway_Homo sapiens_hsa049170.86958214
96Non-small cell lung cancer_Homo sapiens_hsa052230.84538560
97Pyrimidine metabolism_Homo sapiens_hsa002400.84429551
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83492530
99Caffeine metabolism_Homo sapiens_hsa002320.83465573
100Selenocompound metabolism_Homo sapiens_hsa004500.83036075
101Cell cycle_Homo sapiens_hsa041100.82382145
102VEGF signaling pathway_Homo sapiens_hsa043700.81457680
103Glutathione metabolism_Homo sapiens_hsa004800.79438779
104Steroid biosynthesis_Homo sapiens_hsa001000.78465645
105Colorectal cancer_Homo sapiens_hsa052100.77760094
106Oocyte meiosis_Homo sapiens_hsa041140.76260346
107Autoimmune thyroid disease_Homo sapiens_hsa053200.72916283
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71663388
109TGF-beta signaling pathway_Homo sapiens_hsa043500.71528652
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70844805
111Spliceosome_Homo sapiens_hsa030400.69496741
112Endometrial cancer_Homo sapiens_hsa052130.69447263
113Renal cell carcinoma_Homo sapiens_hsa052110.69267822
114Asthma_Homo sapiens_hsa053100.65730389
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65136835
116Renin-angiotensin system_Homo sapiens_hsa046140.64312581
117Notch signaling pathway_Homo sapiens_hsa043300.63894464
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62940315
119RNA transport_Homo sapiens_hsa030130.62494890
120HIF-1 signaling pathway_Homo sapiens_hsa040660.60999390
121FoxO signaling pathway_Homo sapiens_hsa040680.60544118
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.60486627
123Pathways in cancer_Homo sapiens_hsa052000.60077716
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57038003
125mTOR signaling pathway_Homo sapiens_hsa041500.56852594
126Purine metabolism_Homo sapiens_hsa002300.56389943
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55250548
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53913796
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53483318
130Nitrogen metabolism_Homo sapiens_hsa009100.53373132
131Base excision repair_Homo sapiens_hsa034100.51703299
132mRNA surveillance pathway_Homo sapiens_hsa030150.48938134
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48512850
134Sphingolipid metabolism_Homo sapiens_hsa006000.48462689
135Phototransduction_Homo sapiens_hsa047440.48377194
136Insulin resistance_Homo sapiens_hsa049310.46874258
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45144178
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43978394
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.42661844
140Hippo signaling pathway_Homo sapiens_hsa043900.41843811
141* Endocytosis_Homo sapiens_hsa041440.40658860
142N-Glycan biosynthesis_Homo sapiens_hsa005100.40404786
143Mismatch repair_Homo sapiens_hsa034300.39981457
144Pyruvate metabolism_Homo sapiens_hsa006200.38848740
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35713279
146Tryptophan metabolism_Homo sapiens_hsa003800.33598939
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.33283748
148Ether lipid metabolism_Homo sapiens_hsa005650.33189795
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33016746
150Vitamin digestion and absorption_Homo sapiens_hsa049770.25611105
151Peroxisome_Homo sapiens_hsa041460.24469735
152Fatty acid degradation_Homo sapiens_hsa000710.22130908
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21933497
154Metabolic pathways_Homo sapiens_hsa011000.21723486
155Circadian rhythm_Homo sapiens_hsa047100.20518344

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