ARFGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* COPI coating of Golgi vesicle (GO:0048205)6.37997562
2* Golgi transport vesicle coating (GO:0048200)6.37997562
3mannose metabolic process (GO:0006013)4.87684670
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.85828097
5protein retention in ER lumen (GO:0006621)4.73648747
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68744777
7synaptic vesicle maturation (GO:0016188)4.57281586
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.55722835
9locomotory exploration behavior (GO:0035641)4.40398604
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35868719
11* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.32736509
12semaphorin-plexin signaling pathway (GO:0071526)4.12613688
13regulation of synaptic vesicle exocytosis (GO:2000300)3.96758870
14basement membrane organization (GO:0071711)3.87969309
15cerebellar Purkinje cell layer development (GO:0021680)3.80196113
16adherens junction assembly (GO:0034333)3.79848395
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71868090
18* vesicle coating (GO:0006901)3.68459638
19vocalization behavior (GO:0071625)3.68126242
20cell-substrate adherens junction assembly (GO:0007045)3.67169414
21focal adhesion assembly (GO:0048041)3.67169414
22synaptic vesicle exocytosis (GO:0016079)3.66541062
23glutamate secretion (GO:0014047)3.64736784
24regulation of synapse structural plasticity (GO:0051823)3.63496488
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60533567
26regulation of extracellular matrix disassembly (GO:0010715)3.59140108
27* activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.58519122
28layer formation in cerebral cortex (GO:0021819)3.56699814
29regulation of synaptic vesicle transport (GO:1902803)3.55215927
30positive regulation of synapse maturation (GO:0090129)3.52971388
31activation of protein kinase A activity (GO:0034199)3.45419943
32negative regulation of erythrocyte differentiation (GO:0045647)3.42559193
33proline biosynthetic process (GO:0006561)3.40942708
34activation of Rac GTPase activity (GO:0032863)3.39768526
35apoptotic process involved in morphogenesis (GO:0060561)3.39653204
36protein localization to endosome (GO:0036010)3.36934546
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35197277
38* positive regulation of nuclease activity (GO:0032075)3.34109113
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32967919
40cell-substrate junction assembly (GO:0007044)3.30992402
41insulin-like growth factor receptor signaling pathway (GO:0048009)3.28062574
42cell-cell junction maintenance (GO:0045217)3.26282258
43regulation of glutamate receptor signaling pathway (GO:1900449)3.25461169
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21150020
45dendritic spine morphogenesis (GO:0060997)3.19160217
46regulation of neuronal synaptic plasticity (GO:0048168)3.18154667
47regulation of cholesterol homeostasis (GO:2000188)3.17906199
48negative regulation of cell size (GO:0045792)3.16500270
49COPII vesicle coating (GO:0048208)3.14360434
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.08243303
51cell communication by electrical coupling (GO:0010644)3.08152555
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05595011
53positive regulation of Cdc42 GTPase activity (GO:0043089)3.05508028
54epithelial cell-cell adhesion (GO:0090136)3.05346580
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05240650
56regulation of cholesterol biosynthetic process (GO:0045540)3.04476846
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02128147
58exploration behavior (GO:0035640)3.02020828
59dendritic spine organization (GO:0097061)2.98565823
60pinocytosis (GO:0006907)2.97098266
61positive regulation of blood vessel endothelial cell migration (GO:0043536)2.96563316
62regulation of glucose import in response to insulin stimulus (GO:2001273)2.96283450
63establishment of nucleus localization (GO:0040023)2.95920378
64maternal placenta development (GO:0001893)2.91769347
65barbed-end actin filament capping (GO:0051016)2.91342380
66* regulation of nuclease activity (GO:0032069)2.91094274
67* endoplasmic reticulum unfolded protein response (GO:0030968)2.89828452
68regulation of ARF protein signal transduction (GO:0032012)2.89808615
69inner ear receptor cell development (GO:0060119)2.88422817
70neurotransmitter secretion (GO:0007269)2.88083120
71regulation of histone H3-K27 methylation (GO:0061085)2.87545639
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87385614
73positive regulation of fibroblast migration (GO:0010763)2.87155509
74negative regulation of fatty acid transport (GO:2000192)2.86430913
75regulation of apoptotic cell clearance (GO:2000425)2.83975020
76skin morphogenesis (GO:0043589)2.83930667
77positive regulation of receptor recycling (GO:0001921)2.83549597
78regulation of extracellular matrix organization (GO:1903053)2.81745991
79endothelial cell chemotaxis (GO:0035767)2.80299544
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78457380
81protein maturation by protein folding (GO:0022417)2.78005952
82* cellular response to unfolded protein (GO:0034620)2.75671344
83stress fiber assembly (GO:0043149)2.75545337
84sodium ion export (GO:0071436)2.75411975
85plasma membrane repair (GO:0001778)2.74189185
86* ER-nucleus signaling pathway (GO:0006984)2.73141748
87long-term memory (GO:0007616)2.71385120
88proline metabolic process (GO:0006560)2.70465391
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70190869
90positive regulation of extracellular matrix organization (GO:1903055)2.69908554
91protein heterotrimerization (GO:0070208)2.69412629
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69286184
93detection of calcium ion (GO:0005513)2.67798254
94growth hormone secretion (GO:0030252)2.66664269
95atrioventricular valve morphogenesis (GO:0003181)2.66385168
96* regulation of ARF GTPase activity (GO:0032312)2.65938469
97* cellular response to topologically incorrect protein (GO:0035967)2.64578941
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64482277
99histone H4 deacetylation (GO:0070933)2.64363176
100innervation (GO:0060384)2.64302497
101vesicle transport along microtubule (GO:0047496)2.64051729
102neuromuscular process controlling balance (GO:0050885)2.64001449
103regulation of synaptic plasticity (GO:0048167)2.62969664
104cellular potassium ion homeostasis (GO:0030007)2.62919236
105exocrine pancreas development (GO:0031017)2.62338392
106positive regulation of protein kinase C signaling (GO:0090037)2.61748118
107dendrite morphogenesis (GO:0048813)2.61438485
108retrograde transport, endosome to Golgi (GO:0042147)2.60998801
109proline transport (GO:0015824)2.59962917
110regulation of early endosome to late endosome transport (GO:2000641)2.59782128
111signal complex assembly (GO:0007172)2.59645342
112modulation by symbiont of host cellular process (GO:0044068)2.59608444
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.59187910
114peptidyl-proline hydroxylation (GO:0019511)2.58252940
115synaptic transmission, glutamatergic (GO:0035249)2.58113884
116glucose 6-phosphate metabolic process (GO:0051156)2.57957230
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57478416
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.57319277
119cerebellar Purkinje cell differentiation (GO:0021702)2.56904417
120macroautophagy (GO:0016236)2.56056822
121embryonic process involved in female pregnancy (GO:0060136)2.55180928
122neuronal action potential propagation (GO:0019227)2.55081721
123activation of MAPKKK activity (GO:0000185)2.54185183
124positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.53354042
125lung epithelium development (GO:0060428)2.53141831
126negative regulation of viral release from host cell (GO:1902187)2.52857468
127branching involved in mammary gland duct morphogenesis (GO:0060444)2.52817236
128embryo implantation (GO:0007566)2.52802180
129insulin secretion (GO:0030073)2.52513343
130positive regulation of histone deacetylation (GO:0031065)2.52110911
131cellular response to epidermal growth factor stimulus (GO:0071364)2.52043603
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50067994
133establishment of protein localization to Golgi (GO:0072600)2.49877079
134cell volume homeostasis (GO:0006884)2.49716576
135positive regulation of membrane potential (GO:0045838)2.49212008
136activation of JUN kinase activity (GO:0007257)2.49185078
137protein hydroxylation (GO:0018126)2.49080332
138long term synaptic depression (GO:0060292)2.48904615
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48656339
140vascular endothelial growth factor signaling pathway (GO:0038084)2.48601912
141dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48335586
142protein targeting to Golgi (GO:0000042)2.48138834
143desmosome organization (GO:0002934)2.47977292
144apoptotic cell clearance (GO:0043277)2.46908871
145establishment of apical/basal cell polarity (GO:0035089)2.46707375
146endothelial cell morphogenesis (GO:0001886)2.46514795
147protein-lipid complex assembly (GO:0065005)2.46503099
148hemidesmosome assembly (GO:0031581)2.45777723
149heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.44926257
150neuromuscular process controlling posture (GO:0050884)2.44579844
151regulation of excitatory postsynaptic membrane potential (GO:0060079)2.44116202
152response to pheromone (GO:0019236)2.43777340
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43598091
154intra-Golgi vesicle-mediated transport (GO:0006891)2.43272024
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43040488
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42952033
157glial cell proliferation (GO:0014009)2.41878351
158collagen fibril organization (GO:0030199)2.41520845
159positive regulation of protein dephosphorylation (GO:0035307)2.41056498
160endodermal cell differentiation (GO:0035987)2.40310163
161positive regulation of dendrite morphogenesis (GO:0050775)2.40302353
162axonal fasciculation (GO:0007413)2.39633178
163regulation of dendritic spine morphogenesis (GO:0061001)2.39249540
164response to laminar fluid shear stress (GO:0034616)2.39023691
165plasma lipoprotein particle assembly (GO:0034377)2.38536394
166endocytic recycling (GO:0032456)2.38417784
167protein localization to synapse (GO:0035418)2.37285685
168positive regulation of vesicle fusion (GO:0031340)2.36365700
169alanine transport (GO:0032328)2.35442119
170membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34841799
171protein carboxylation (GO:0018214)2.34687940
172peptidyl-glutamic acid carboxylation (GO:0017187)2.34687940
173long-term synaptic potentiation (GO:0060291)2.34609141
174regulation of nucleobase-containing compound transport (GO:0032239)2.34577472
175neuron projection extension involved in neuron projection guidance (GO:1902284)2.34438834
176axon extension involved in axon guidance (GO:0048846)2.34438834
177pentose-phosphate shunt (GO:0006098)2.34076689
178modulation by virus of host process (GO:0019054)2.34016212
179UV protection (GO:0009650)2.33490451
180GDP-mannose metabolic process (GO:0019673)2.32931535
181regulation of cholesterol metabolic process (GO:0090181)2.32257334
182cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.31430350
183actin filament depolymerization (GO:0030042)2.27881671
184intracellular estrogen receptor signaling pathway (GO:0030520)2.26999045
185receptor catabolic process (GO:0032801)2.26681388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20806117
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.30358045
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.16300731
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.76433907
5DROSHA_22980978_ChIP-Seq_HELA_Human2.68976398
6VDR_21846776_ChIP-Seq_THP-1_Human2.50284789
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47109462
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36854544
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36643402
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26221005
11ZNF263_19887448_ChIP-Seq_K562_Human2.24270646
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22009620
13LXR_22292898_ChIP-Seq_THP-1_Human2.14773846
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12255041
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08989218
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08789625
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05790596
18* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.03350785
19KDM2B_26808549_Chip-Seq_K562_Human2.03138421
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01356862
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99999706
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97819674
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97819674
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95754775
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93971211
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93265220
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92316414
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90694835
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.90553604
30* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89904994
31REST_21632747_ChIP-Seq_MESCs_Mouse1.87107641
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85536569
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.85129472
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.80694897
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79896860
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.77710476
37KDM2B_26808549_Chip-Seq_DND41_Human1.74035845
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73166708
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67360834
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64275410
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.62112221
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61814230
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60454664
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56282280
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56276143
46ZNF274_21170338_ChIP-Seq_K562_Hela1.55754286
47* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.55748148
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.55703261
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53744546
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52584727
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52000136
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.51713027
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48544736
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48457336
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.46649270
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44848414
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43245418
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.41695138
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40751863
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40127367
61MYC_22102868_ChIP-Seq_BL_Human1.39556872
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38457920
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34958523
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.34171119
65CREB1_26743006_Chip-Seq_LNCaP_Human1.33875825
66CLOCK_20551151_ChIP-Seq_293T_Human1.32841774
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32018222
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31404668
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31244040
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.31201516
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.30621497
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30323454
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29230764
74NCOR1_26117541_ChIP-Seq_K562_Human1.29092021
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.28787520
76VDR_24763502_ChIP-Seq_THP-1_Human1.27744251
77ATF3_27146783_Chip-Seq_COLON_Human1.27446188
78* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26991697
79SMC4_20622854_ChIP-Seq_HELA_Human1.25982123
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25878558
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.25490952
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.25358385
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.23767336
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23615658
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23488765
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.22994862
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21986806
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21662596
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21183024
90RACK7_27058665_Chip-Seq_MCF-7_Human1.21159878
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20798388
92GATA1_22025678_ChIP-Seq_K562_Human1.20391779
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20136149
94AR_19668381_ChIP-Seq_PC3_Human1.20095027
95TCF7_22412390_ChIP-Seq_EML_Mouse1.19532806
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18696963
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18211515
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17560541
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17337541
100MAF_26560356_Chip-Seq_TH1_Human1.15678490
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15240081
102MAF_26560356_Chip-Seq_TH2_Human1.15100323
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14927373
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14876593
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14855140
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14719856
107TP53_23651856_ChIP-Seq_MEFs_Mouse1.14296299
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12870797
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.12387795
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11923410
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11564163
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10723070
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.09800952
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09745091
115* BCOR_27268052_Chip-Seq_Bcells_Human1.09549588
116CTCF_27219007_Chip-Seq_Bcells_Human1.09062053
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06543653
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06041056
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05050623
120GBX2_23144817_ChIP-Seq_PC3_Human1.05027647
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04955644
122UTX_26944678_Chip-Seq_JUKART_Human1.04423355
123ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04086127
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03727938
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03569512
126* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03513849
127NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03325634
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03203083
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03093268
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.02991421
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01195952
132* RARA_24833708_ChIP-Seq_LIVER_Mouse1.01014974
133RARB_24833708_ChIP-Seq_LIVER_Mouse1.00725073
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00477239
135TP53_22127205_ChIP-Seq_IMR90_Human0.99917560
136KLF4_19829295_ChIP-Seq_ESCs_Human0.99411669
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99384282
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98714324
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.98618174
140BCL6_27268052_Chip-Seq_Bcells_Human0.98059621
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.97517630
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97420180
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97300164
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97154981
145SPI1_23127762_ChIP-Seq_K562_Human0.96734412
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.95752976
147* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95424248
148P68_20966046_ChIP-Seq_HELA_Human0.94611347
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94292830
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91876732
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.90553106
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89148819
153* MITF_21258399_ChIP-Seq_MELANOMA_Human0.87612196
154AR_21572438_ChIP-Seq_LNCaP_Human0.87300415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.44049685
2MP0005058_abnormal_lysosome_morphology3.87153581
3MP0008438_abnormal_cutaneous_collagen3.86903774
4MP0009780_abnormal_chondrocyte_physiolo3.36364323
5MP0003283_abnormal_digestive_organ3.19618720
6MP0000013_abnormal_adipose_tissue3.06801727
7MP0001849_ear_inflammation2.91833357
8MP0002909_abnormal_adrenal_gland2.80408013
9MP0003635_abnormal_synaptic_transmissio2.80077473
10MP0008260_abnormal_autophagy2.77549063
11MP0005451_abnormal_body_composition2.70107495
12MP0005409_darkened_coat_color2.51737493
13MP0003705_abnormal_hypodermis_morpholog2.42476822
14MP0004858_abnormal_nervous_system2.34740635
15MP0005503_abnormal_tendon_morphology2.29305426
16MP0009840_abnormal_foam_cell2.27492174
17MP0002837_dystrophic_cardiac_calcinosis2.27154468
18MP0004270_analgesia2.21207266
19MP0005275_abnormal_skin_tensile2.09598014
20MP0002063_abnormal_learning/memory/cond2.04900287
21MP0008961_abnormal_basal_metabolism2.03838331
22MP0000569_abnormal_digit_pigmentation2.01800646
23MP0003122_maternal_imprinting2.01772354
24MP0003453_abnormal_keratinocyte_physiol1.83767848
25MP0002822_catalepsy1.83423675
26MP0003183_abnormal_peptide_metabolism1.81617582
27MP0003329_amyloid_beta_deposits1.79805320
28MP0003045_fibrosis1.79129993
29MP0000003_abnormal_adipose_tissue1.77275827
30MP0002877_abnormal_melanocyte_morpholog1.71503622
31MP0010386_abnormal_urinary_bladder1.71372729
32MP0005360_urolithiasis1.71145686
33MP0001348_abnormal_lacrimal_gland1.70735775
34MP0004233_abnormal_muscle_weight1.69942431
35MP0002249_abnormal_larynx_morphology1.69347343
36MP0009745_abnormal_behavioral_response1.65859831
37MP0009384_cardiac_valve_regurgitation1.64191434
38MP0002064_seizures1.62466777
39MP0000751_myopathy1.61171828
40MP0003436_decreased_susceptibility_to1.61149985
41MP0003191_abnormal_cellular_cholesterol1.59296116
42MP0001944_abnormal_pancreas_morphology1.56993725
43MP0009278_abnormal_bone_marrow1.52782860
44MP0000858_altered_metastatic_potential1.49578671
45MP0003279_aneurysm1.48432588
46MP0004145_abnormal_muscle_electrophysio1.47214464
47MP0004811_abnormal_neuron_physiology1.46832451
48MP0003300_gastrointestinal_ulcer1.46410664
49MP0005023_abnormal_wound_healing1.45097375
50MP0002572_abnormal_emotion/affect_behav1.44150757
51MP0005623_abnormal_meninges_morphology1.43388449
52MP0002896_abnormal_bone_mineralization1.41195846
53MP0002060_abnormal_skin_morphology1.41101345
54MP0002693_abnormal_pancreas_physiology1.40533848
55MP0000767_abnormal_smooth_muscle1.39157320
56MP0003880_abnormal_central_pattern1.38988484
57MP0004185_abnormal_adipocyte_glucose1.38012867
58MP0008569_lethality_at_weaning1.33796935
59MP0003172_abnormal_lysosome_physiology1.33318214
60MP0010030_abnormal_orbit_morphology1.32847754
61MP0003303_peritoneal_inflammation1.29151982
62MP0005220_abnormal_exocrine_pancreas1.29077318
63MP0001299_abnormal_eye_distance/1.28641298
64MP0004381_abnormal_hair_follicle1.28626570
65MP0004264_abnormal_extraembryonic_tissu1.26871923
66MP0005257_abnormal_intraocular_pressure1.25944112
67MP0003879_abnormal_hair_cell1.23057793
68MP0004947_skin_inflammation1.22379004
69MP0006054_spinal_hemorrhage1.22150965
70MP0002933_joint_inflammation1.20421563
71MP0000955_abnormal_spinal_cord1.18298321
72MP0003091_abnormal_cell_migration1.18096502
73MP0004272_abnormal_basement_membrane1.17939609
74MP0002998_abnormal_bone_remodeling1.17009687
75MP0000733_abnormal_muscle_development1.14311018
76MP0005666_abnormal_adipose_tissue1.14006493
77MP0002734_abnormal_mechanical_nocicepti1.12787838
78MP0001958_emphysema1.12715272
79MP0002184_abnormal_innervation1.10756526
80MP0009046_muscle_twitch1.10088158
81MP0002089_abnormal_postnatal_growth/wei1.09275506
82MP0001501_abnormal_sleep_pattern1.06896363
83MP0001915_intracranial_hemorrhage1.06876842
84MP0001968_abnormal_touch/_nociception1.04712771
85MP0004043_abnormal_pH_regulation1.04208533
86MP0000566_synostosis1.04030440
87MP0002272_abnormal_nervous_system1.01959949
88MP0002796_impaired_skin_barrier1.01873015
89MP0002269_muscular_atrophy1.01709137
90MP0002733_abnormal_thermal_nociception1.01130340
91MP0002078_abnormal_glucose_homeostasis1.00841645
92MP0005076_abnormal_cell_differentiation0.99441884
93MP0003566_abnormal_cell_adhesion0.97914024
94MP0000537_abnormal_urethra_morphology0.97536119
95MP0005621_abnormal_cell_physiology0.96308778
96MP0002234_abnormal_pharynx_morphology0.95851093
97MP0001440_abnormal_grooming_behavior0.95030934
98MP0003119_abnormal_digestive_system0.94935350
99MP0000467_abnormal_esophagus_morphology0.94423190
100MP0005508_abnormal_skeleton_morphology0.92760958
101MP0000747_muscle_weakness0.92603866
102MP0003787_abnormal_imprinting0.89338174
103MP0001970_abnormal_pain_threshold0.88472059
104MP0002557_abnormal_social/conspecific_i0.87541238
105MP0003942_abnormal_urinary_system0.87256565
106MP0002254_reproductive_system_inflammat0.87182787
107MP0005501_abnormal_skin_physiology0.86607914
108MP0003634_abnormal_glial_cell0.86593762
109MP0000759_abnormal_skeletal_muscle0.86306786
110MP0010234_abnormal_vibrissa_follicle0.85668105
111MP0002108_abnormal_muscle_morphology0.85015051
112MP0001243_abnormal_dermal_layer0.84444445
113MP0005375_adipose_tissue_phenotype0.83895605
114MP0001177_atelectasis0.81318837
115MP0003633_abnormal_nervous_system0.79752580
116MP0000534_abnormal_ureter_morphology0.79212482
117MP0009672_abnormal_birth_weight0.78421775
118MP0000604_amyloidosis0.78023431
119MP0005448_abnormal_energy_balance0.77666084
120MP0001730_embryonic_growth_arrest0.77653891
121MP0003123_paternal_imprinting0.77469024
122MP0001486_abnormal_startle_reflex0.76725311
123MP0001533_abnormal_skeleton_physiology0.76651427
124MP0000371_diluted_coat_color0.76601226
125MP0002066_abnormal_motor_capabilities/c0.76420963
126MP0000428_abnormal_craniofacial_morphol0.76278772
127MP0002168_other_aberrant_phenotype0.75551045
128MP0004130_abnormal_muscle_cell0.75121310
129MP0010630_abnormal_cardiac_muscle0.74567550
130MP0009931_abnormal_skin_appearance0.73944903
131MP0003115_abnormal_respiratory_system0.73589258
132MP0003385_abnormal_body_wall0.73518705
133MP0003959_abnormal_lean_body0.72891296
134MP0002069_abnormal_eating/drinking_beha0.72511628
135MP0005390_skeleton_phenotype0.72103592
136MP0002882_abnormal_neuron_morphology0.72027964
137MP0002736_abnormal_nociception_after0.72020565
138MP0001614_abnormal_blood_vessel0.71831408
139MP0006138_congestive_heart_failure0.71777596
140MP0002396_abnormal_hematopoietic_system0.71404313
141MP0000678_abnormal_parathyroid_gland0.71369843
142MP0000681_abnormal_thyroid_gland0.71067021
143MP0002067_abnormal_sensory_capabilities0.70870381
144MP0010368_abnormal_lymphatic_system0.70502279
145MP0002932_abnormal_joint_morphology0.70400849
146MP0005670_abnormal_white_adipose0.70003661
147MP0002925_abnormal_cardiovascular_devel0.70001478
148MP0001270_distended_abdomen0.69662803
149MP0000462_abnormal_digestive_system0.69608873
150MP0009333_abnormal_splenocyte_physiolog0.69461384
151MP0004924_abnormal_behavior0.69395061
152MP0005386_behavior/neurological_phenoty0.69395061
153MP0002152_abnormal_brain_morphology0.69387451
154MP0004087_abnormal_muscle_fiber0.69150159
155MP0004510_myositis0.68073554
156MP0000778_abnormal_nervous_system0.67556718
157MP0002113_abnormal_skeleton_development0.67493512
158MP0003795_abnormal_bone_structure0.66097264
159MP0001216_abnormal_epidermal_layer0.65095984
160MP0002086_abnormal_extraembryonic_tissu0.65025205
161MP0003075_altered_response_to0.63046369
162MP0010352_gastrointestinal_tract_polyps0.62719774
163MP0002075_abnormal_coat/hair_pigmentati0.60229378

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.68439713
2Cerebral aneurysm (HP:0004944)3.80995599
3Premature rupture of membranes (HP:0001788)3.75781309
4Broad face (HP:0000283)3.30902103
5J-shaped sella turcica (HP:0002680)3.02125355
6Shallow orbits (HP:0000586)2.98383027
7Deep venous thrombosis (HP:0002625)2.94915214
8Distal upper limb amyotrophy (HP:0007149)2.94175312
9Upper limb amyotrophy (HP:0009129)2.94175312
10Dilatation of the ascending aorta (HP:0005111)2.91558132
11Visual hallucinations (HP:0002367)2.91100870
12Biconcave vertebral bodies (HP:0004586)2.90475267
13Ulnar bowing (HP:0003031)2.89742721
14Focal seizures (HP:0007359)2.88768356
15Neoplasm of the heart (HP:0100544)2.87304807
16Hand muscle atrophy (HP:0009130)2.86840866
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.86073767
18Obstructive sleep apnea (HP:0002870)2.80826759
19Bladder diverticulum (HP:0000015)2.79388659
20Focal motor seizures (HP:0011153)2.72839792
21Flat acetabular roof (HP:0003180)2.67116795
22Bowel diverticulosis (HP:0005222)2.62453305
23Aneurysm (HP:0002617)2.61506180
24Nuclear cataract (HP:0100018)2.61193311
25Distal lower limb amyotrophy (HP:0008944)2.59535517
26Hyperinsulinemic hypoglycemia (HP:0000825)2.55435264
27Aortic dissection (HP:0002647)2.49718418
28Hemorrhage of the eye (HP:0011885)2.49712036
29Stridor (HP:0010307)2.49191275
30Genu recurvatum (HP:0002816)2.48011386
31Abnormality of the lower motor neuron (HP:0002366)2.45801815
32Ankle contracture (HP:0006466)2.45232378
33Myokymia (HP:0002411)2.45096096
34Atrophic scars (HP:0001075)2.39633315
35Increased connective tissue (HP:0009025)2.36385109
36Turricephaly (HP:0000262)2.35937108
37Mitral valve prolapse (HP:0001634)2.35922237
38Mitral regurgitation (HP:0001653)2.35817477
39Disproportionate tall stature (HP:0001519)2.34751446
40Dysostosis multiplex (HP:0000943)2.34389730
41Broad metatarsal (HP:0001783)2.34022532
42Long toe (HP:0010511)2.32141071
43Congenital glaucoma (HP:0001087)2.31337338
44Thin bony cortex (HP:0002753)2.30617140
45Mildly elevated creatine phosphokinase (HP:0008180)2.29301631
46Pointed chin (HP:0000307)2.28810884
47Aortic aneurysm (HP:0004942)2.26277073
48Abnormality of the Achilles tendon (HP:0005109)2.25050831
49Atonic seizures (HP:0010819)2.24093363
50Type 1 muscle fiber predominance (HP:0003803)2.21980173
51Hypoglycemic seizures (HP:0002173)2.20693161
52Hyperglycemia (HP:0003074)2.20318741
53Resting tremor (HP:0002322)2.19746629
54Hypoventilation (HP:0002791)2.18472181
55Cervical subluxation (HP:0003308)2.18084856
56Depression (HP:0000716)2.15609166
57Increased variability in muscle fiber diameter (HP:0003557)2.15082844
58Deep palmar crease (HP:0006191)2.13774704
59Abnormality of dentin (HP:0010299)2.13381271
60Neurofibrillary tangles (HP:0002185)2.13336812
61Spinal rigidity (HP:0003306)2.13291442
62Urinary glycosaminoglycan excretion (HP:0003541)2.12313842
63Mucopolysacchariduria (HP:0008155)2.12313842
64Fragile skin (HP:0001030)2.10809536
65Asymmetry of the thorax (HP:0001555)2.10711824
66EEG with generalized epileptiform discharges (HP:0011198)2.10684501
67Macroorchidism (HP:0000053)2.10047040
68Insomnia (HP:0100785)2.10026274
69Hemiplegia (HP:0002301)2.09765112
70Striae distensae (HP:0001065)2.09267057
71Epileptiform EEG discharges (HP:0011182)2.08867632
72Hyperacusis (HP:0010780)2.08707084
73Hypsarrhythmia (HP:0002521)2.06748826
74Spinal muscular atrophy (HP:0007269)2.06309629
75Ventricular fibrillation (HP:0001663)2.03249917
76Abnormality of polysaccharide metabolism (HP:0011012)2.02610216
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02610216
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02610216
79Bundle branch block (HP:0011710)2.01292695
80Impaired social interactions (HP:0000735)1.99935785
81Abnormal social behavior (HP:0012433)1.99935785
82Bronchomalacia (HP:0002780)1.98663060
83Joint stiffness (HP:0001387)1.98084750
84Distal lower limb muscle weakness (HP:0009053)1.97327535
85Cerebral inclusion bodies (HP:0100314)1.97129081
86Epileptic encephalopathy (HP:0200134)1.96612118
87Supranuclear gaze palsy (HP:0000605)1.96368075
88Torticollis (HP:0000473)1.95506884
89Metaphyseal cupping (HP:0003021)1.94735346
90Poor eye contact (HP:0000817)1.94266681
91Lymphangioma (HP:0100764)1.93895310
92Hypercortisolism (HP:0001578)1.92376703
93Insulin-resistant diabetes mellitus (HP:0000831)1.91981499
94Thin ribs (HP:0000883)1.90601921
95Abnormality of the thoracic spine (HP:0100711)1.90452984
96Global brain atrophy (HP:0002283)1.89400964
97Soft skin (HP:0000977)1.89214619
98Hyperextensible skin (HP:0000974)1.87044209
99Vascular tortuosity (HP:0004948)1.84416200
100Slender build (HP:0001533)1.83833663
101Abnormality of oral frenula (HP:0000190)1.83706930
102Buphthalmos (HP:0000557)1.83123244
103Truncal ataxia (HP:0002078)1.83089565
104Arterial tortuosity (HP:0005116)1.82908224
105Spinal canal stenosis (HP:0003416)1.82857279
106Broad ribs (HP:0000885)1.82818805
107Achilles tendon contracture (HP:0001771)1.82029216
108Overgrowth (HP:0001548)1.81479903
109Abnormality of the acetabulum (HP:0003170)1.81174257
110Difficulty climbing stairs (HP:0003551)1.80903880
111Neonatal short-limb short stature (HP:0008921)1.80405676
112Absence seizures (HP:0002121)1.80340753
113Premature skin wrinkling (HP:0100678)1.80045662
114Long palpebral fissure (HP:0000637)1.79372618
115Peritonitis (HP:0002586)1.78754558
116Coxa vara (HP:0002812)1.78417896
117Deformed sella turcica (HP:0002681)1.77225603
118Lower limb amyotrophy (HP:0007210)1.77123540
119Impaired smooth pursuit (HP:0007772)1.77057769
120Ankle clonus (HP:0011448)1.76869363
121Renal duplication (HP:0000075)1.76607907
122Cupped ribs (HP:0000887)1.76415427
123Abnormality of skeletal muscle fiber size (HP:0012084)1.75406447
124Broad palm (HP:0001169)1.75092127
125Vertebral compression fractures (HP:0002953)1.74215827
126Short nail (HP:0001799)1.73946075
127Aortic regurgitation (HP:0001659)1.73723427
128Blue sclerae (HP:0000592)1.73530895
129Megalencephaly (HP:0001355)1.73127448
130Symptomatic seizures (HP:0011145)1.71580279
131Easy fatigability (HP:0003388)1.71012182
132Generalized hyperpigmentation (HP:0007440)1.70910652
133Focal dystonia (HP:0004373)1.70910563
134Impaired vibration sensation in the lower limbs (HP:0002166)1.70670142
135Wormian bones (HP:0002645)1.70629292
136Elbow flexion contracture (HP:0002987)1.70194246
137Abnormal ossification of hand bones (HP:0005921)1.70086187
138Ankyloglossia (HP:0010296)1.69840758
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.69833390
140Joint laxity (HP:0001388)1.69384866
141Advanced eruption of teeth (HP:0006288)1.69373741
142Dislocated radial head (HP:0003083)1.67511284
143Nonimmune hydrops fetalis (HP:0001790)1.67054819
144Spinal cord lesions (HP:0100561)1.66566348
145Syringomyelia (HP:0003396)1.66566348
146Abnormality of endocrine pancreas physiology (HP:0012093)1.66520806
147Abnormality of the pancreatic islet cells (HP:0006476)1.66520806
148Reticulocytosis (HP:0001923)1.66432185
149Retinal atrophy (HP:0001105)1.66416885
150Agitation (HP:0000713)1.66219530
151Action tremor (HP:0002345)1.66182345
152Cholecystitis (HP:0001082)1.65897389
153Abnormal gallbladder physiology (HP:0012438)1.65897389
154Abnormality of carpal bone ossification (HP:0006257)1.65644817
155Myopathic facies (HP:0002058)1.65206168
156Enlarged penis (HP:0000040)1.64415115
157Natal tooth (HP:0000695)1.62830208
158Platyspondyly (HP:0000926)1.61773022
159Atelectasis (HP:0100750)1.60699010
160Flattened epiphyses (HP:0003071)1.60531022
161Axonal loss (HP:0003447)1.58157098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.53226192
2NTRK33.00872328
3EPHA43.00395546
4PRKD32.95558775
5MAP3K92.79585100
6SMG12.77628927
7PDGFRA2.52723113
8INSRR2.49754835
9DDR22.44163161
10PKN22.31724953
11RIPK12.30270204
12ERN12.25401970
13IRAK32.20146248
14MAP3K42.11932932
15EPHA22.07861683
16DAPK22.00824515
17CDK121.99767201
18NTRK11.92617811
19NME21.88210960
20CAMKK11.87977121
21KSR21.87815928
22PAK61.86878110
23SCYL21.86687785
24MINK11.59069888
25MST1R1.58412001
26SIK21.55368903
27MAP2K31.52809199
28PTK21.51199474
29TTN1.50530746
30KSR11.49942307
31SIK11.46827143
32RET1.46790071
33TAOK11.44877318
34PRKCH1.44728104
35CAMKK21.44455456
36PAK31.41384951
37PTK61.40431788
38LMTK21.39479804
39MAP3K21.31188633
40MAP2K41.30646169
41PAK41.28992927
42CDC42BPA1.27652768
43DAPK11.26957109
44MAP3K61.21353012
45MAP3K11.13239135
46MARK21.12702476
47FER1.11029189
48MAP3K31.10982842
49ALK1.09887728
50LATS21.08170735
51DMPK1.07420913
52CDK51.07411597
53EEF2K1.07122977
54MAP3K111.03429732
55EPHB11.02985226
56TYRO31.02077473
57HIPK21.00168028
58STK380.99508725
59CAMK1G0.97917845
60MAP3K130.95308083
61UHMK10.94113353
62MET0.93911152
63MARK10.92924353
64MAP2K70.91449566
65ICK0.91340450
66FGFR30.90409279
67PAK20.87775301
68PTK2B0.85995829
69PDGFRB0.80526271
70TBK10.80244923
71ZAP700.77038177
72NTRK20.76973957
73FRK0.76923294
74RPS6KL10.76900565
75RPS6KC10.76900565
76DAPK30.76810539
77CAMK1D0.76285795
78MAP3K100.76040507
79TAOK20.75028212
80RIPK40.74816696
81PASK0.74623163
82MTOR0.73683980
83CAMK10.73562710
84TYK20.71341962
85MAP2K10.70807519
86PRKG20.70547876
87MAP2K60.69456493
88MAP4K10.66631611
89MAP3K70.65174883
90TNK20.63801909
91SIK30.63385828
92MAPK110.60295600
93KDR0.59426090
94JAK10.59026549
95PRKCG0.57490250
96MAP3K140.55308413
97TESK10.55075354
98FLT30.54438435
99FES0.53086776
100RPS6KA60.52989782
101CDK70.52964199
102SGK30.52315591
103PDPK10.51247839
104MAP2K20.51144123
105PRPF4B0.51071132
106MAP3K80.50947872
107AKT30.50730699
108TESK20.50507758
109FGFR40.50068939
110PLK20.49291155
111CDK180.48138344
112CDK150.47410032
113CAMK40.47296516
114RPS6KB20.46149482
115PDK10.45236395
116TAOK30.44658228
117IRAK20.44124889
118BCKDK0.43775539
119PRKD10.43734895
120CDK40.43078142
121CDK140.42546796
122FYN0.42496872
123FGR0.42286958
124FGFR10.42207345
125RPS6KA20.41728471
126ROCK10.40899970
127RAF10.40151798
128CDK11A0.40042706
129LATS10.39881496
130JAK30.38736247
131SRC0.38476062
132PRKD20.38364347
133MAPKAPK30.37787793
134BMX0.37699997
135ARAF0.37249328
136SGK10.37000727
137CHUK0.35664551
138MATK0.35611890
139DYRK1B0.35349526
140GRK60.34258860
141BRAF0.34001334
142MAPKAPK20.33750204
143ERBB20.33587461
144LRRK20.33192608
145EPHB20.32584277
146PIM20.32546691
147NME10.32476755
148MAPK120.31697141
149FGFR20.30392226
150MAPK100.28380387
151MAPK80.28018178

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.82370397
2Insulin secretion_Homo sapiens_hsa049112.39115316
3Synaptic vesicle cycle_Homo sapiens_hsa047212.37073468
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.32955174
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.21463452
6Notch signaling pathway_Homo sapiens_hsa043302.19225967
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16232504
8Type II diabetes mellitus_Homo sapiens_hsa049302.06127639
9Long-term potentiation_Homo sapiens_hsa047202.03470589
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01676174
11Circadian entrainment_Homo sapiens_hsa047131.90431233
12Amphetamine addiction_Homo sapiens_hsa050311.86458640
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.77933481
14Acute myeloid leukemia_Homo sapiens_hsa052211.73039079
15Fructose and mannose metabolism_Homo sapiens_hsa000511.72951738
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67110317
17Olfactory transduction_Homo sapiens_hsa047401.65573551
18Dopaminergic synapse_Homo sapiens_hsa047281.63966147
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62059591
20GABAergic synapse_Homo sapiens_hsa047271.58532908
21Nicotine addiction_Homo sapiens_hsa050331.57764901
22Cocaine addiction_Homo sapiens_hsa050301.56356841
23Cholinergic synapse_Homo sapiens_hsa047251.52296501
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51872466
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50398862
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48827971
27Morphine addiction_Homo sapiens_hsa050321.48813033
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46622553
29Glutamatergic synapse_Homo sapiens_hsa047241.44113965
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43462241
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40388011
32Gastric acid secretion_Homo sapiens_hsa049711.35574960
33GnRH signaling pathway_Homo sapiens_hsa049121.34141668
34Glioma_Homo sapiens_hsa052141.33651806
35mTOR signaling pathway_Homo sapiens_hsa041501.33362803
36Vibrio cholerae infection_Homo sapiens_hsa051101.31487381
37Galactose metabolism_Homo sapiens_hsa000521.30980240
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.30136407
39Estrogen signaling pathway_Homo sapiens_hsa049151.29995252
40Oxytocin signaling pathway_Homo sapiens_hsa049211.28601140
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26708203
42Salivary secretion_Homo sapiens_hsa049701.25521595
43Pancreatic secretion_Homo sapiens_hsa049721.25084899
44Small cell lung cancer_Homo sapiens_hsa052221.22321314
45Pancreatic cancer_Homo sapiens_hsa052121.22285374
46Pentose phosphate pathway_Homo sapiens_hsa000301.16203379
47Protein digestion and absorption_Homo sapiens_hsa049741.12436433
48Gap junction_Homo sapiens_hsa045401.10494651
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.10436943
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09819678
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09746880
52Dilated cardiomyopathy_Homo sapiens_hsa054141.09202015
53cAMP signaling pathway_Homo sapiens_hsa040241.05418808
54Taste transduction_Homo sapiens_hsa047421.04218794
55Thyroid cancer_Homo sapiens_hsa052161.03944549
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03840379
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03694575
58Focal adhesion_Homo sapiens_hsa045101.01864808
59Calcium signaling pathway_Homo sapiens_hsa040200.99151249
60Sulfur relay system_Homo sapiens_hsa041220.98187013
61ErbB signaling pathway_Homo sapiens_hsa040120.97998205
62Renin secretion_Homo sapiens_hsa049240.97661910
63VEGF signaling pathway_Homo sapiens_hsa043700.96586369
64Thyroid hormone synthesis_Homo sapiens_hsa049180.95371168
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95172374
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.92964824
67Insulin signaling pathway_Homo sapiens_hsa049100.92781396
68Glucagon signaling pathway_Homo sapiens_hsa049220.90467240
69B cell receptor signaling pathway_Homo sapiens_hsa046620.90349163
70Biosynthesis of amino acids_Homo sapiens_hsa012300.89891209
71Long-term depression_Homo sapiens_hsa047300.89564817
72Vitamin B6 metabolism_Homo sapiens_hsa007500.87405973
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87354353
74TNF signaling pathway_Homo sapiens_hsa046680.86840071
75Bladder cancer_Homo sapiens_hsa052190.86523740
76Osteoclast differentiation_Homo sapiens_hsa043800.86232897
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.86132879
78Hepatitis C_Homo sapiens_hsa051600.86116565
79Melanogenesis_Homo sapiens_hsa049160.85801213
80Complement and coagulation cascades_Homo sapiens_hsa046100.85449966
81Insulin resistance_Homo sapiens_hsa049310.84567740
82MicroRNAs in cancer_Homo sapiens_hsa052060.84333294
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83860760
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82478037
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82227956
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81944742
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.81684812
88Endometrial cancer_Homo sapiens_hsa052130.81342166
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81274387
90Toxoplasmosis_Homo sapiens_hsa051450.78772994
91Proteoglycans in cancer_Homo sapiens_hsa052050.77748458
92Hepatitis B_Homo sapiens_hsa051610.77493065
93Adherens junction_Homo sapiens_hsa045200.77339318
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77262782
95N-Glycan biosynthesis_Homo sapiens_hsa005100.77201716
96Lysine degradation_Homo sapiens_hsa003100.76221978
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75977787
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75274096
99HIF-1 signaling pathway_Homo sapiens_hsa040660.74845216
100ECM-receptor interaction_Homo sapiens_hsa045120.74014214
101Prostate cancer_Homo sapiens_hsa052150.73917092
102Non-small cell lung cancer_Homo sapiens_hsa052230.73742602
103Serotonergic synapse_Homo sapiens_hsa047260.72492115
104Chronic myeloid leukemia_Homo sapiens_hsa052200.72282132
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72100589
106Axon guidance_Homo sapiens_hsa043600.71388161
107Prion diseases_Homo sapiens_hsa050200.70243767
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.69783522
109Salmonella infection_Homo sapiens_hsa051320.69597585
110Apoptosis_Homo sapiens_hsa042100.68813346
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67815889
112Shigellosis_Homo sapiens_hsa051310.67146168
113Type I diabetes mellitus_Homo sapiens_hsa049400.67003843
114Prolactin signaling pathway_Homo sapiens_hsa049170.66886194
115Lysosome_Homo sapiens_hsa041420.66649963
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.65922555
117Amoebiasis_Homo sapiens_hsa051460.64356082
118Choline metabolism in cancer_Homo sapiens_hsa052310.63974255
119Rap1 signaling pathway_Homo sapiens_hsa040150.63782020
120MAPK signaling pathway_Homo sapiens_hsa040100.63388128
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62624910
122Pertussis_Homo sapiens_hsa051330.62462513
123* Endocytosis_Homo sapiens_hsa041440.62242962
124AMPK signaling pathway_Homo sapiens_hsa041520.61795080
125Viral carcinogenesis_Homo sapiens_hsa052030.60715850
126Renal cell carcinoma_Homo sapiens_hsa052110.59126007
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58900889
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57749281
129Influenza A_Homo sapiens_hsa051640.57578955
130HTLV-I infection_Homo sapiens_hsa051660.57036128
131Collecting duct acid secretion_Homo sapiens_hsa049660.56626517
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53982252
133Arginine biosynthesis_Homo sapiens_hsa002200.53181395
134Pathways in cancer_Homo sapiens_hsa052000.52329143
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.51826460
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51609097
137Circadian rhythm_Homo sapiens_hsa047100.51230705
138Oocyte meiosis_Homo sapiens_hsa041140.50875292
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.50434308
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50108794
141Colorectal cancer_Homo sapiens_hsa052100.49801515
142Inositol phosphate metabolism_Homo sapiens_hsa005620.48853809
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48601175
144Leishmaniasis_Homo sapiens_hsa051400.48265823
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.48245346
146Wnt signaling pathway_Homo sapiens_hsa043100.47995785
147Sphingolipid metabolism_Homo sapiens_hsa006000.47918100
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47712392
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47059855

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