ARFGAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.56993449
2L-phenylalanine catabolic process (GO:0006559)6.56993449
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.29978227
4L-phenylalanine metabolic process (GO:0006558)6.29978227
5alpha-linolenic acid metabolic process (GO:0036109)5.83448526
6aromatic amino acid family catabolic process (GO:0009074)5.77827903
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.60280435
8negative regulation of erythrocyte differentiation (GO:0045647)5.46684199
9kynurenine metabolic process (GO:0070189)5.34794743
10glyoxylate metabolic process (GO:0046487)5.28066775
11bile acid biosynthetic process (GO:0006699)5.25862207
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.23441947
13negative regulation of fibrinolysis (GO:0051918)5.14246225
14lysine catabolic process (GO:0006554)5.14175398
15lysine metabolic process (GO:0006553)5.14175398
16tryptophan catabolic process (GO:0006569)5.08800209
17indole-containing compound catabolic process (GO:0042436)5.08800209
18indolalkylamine catabolic process (GO:0046218)5.08800209
19urea cycle (GO:0000050)5.02735445
20urea metabolic process (GO:0019627)5.02735445
21high-density lipoprotein particle remodeling (GO:0034375)4.95557730
22sulfur amino acid catabolic process (GO:0000098)4.89702422
23protein carboxylation (GO:0018214)4.89388657
24peptidyl-glutamic acid carboxylation (GO:0017187)4.89388657
25complement activation, alternative pathway (GO:0006957)4.87031127
26cysteine metabolic process (GO:0006534)4.79482832
27tryptophan metabolic process (GO:0006568)4.78342177
28regulation of protein activation cascade (GO:2000257)4.76275894
29regulation of fibrinolysis (GO:0051917)4.66818427
30regulation of triglyceride catabolic process (GO:0010896)4.60216494
31ethanol oxidation (GO:0006069)4.54006950
32nitrogen cycle metabolic process (GO:0071941)4.53221450
33amino-acid betaine metabolic process (GO:0006577)4.49217310
34regulation of complement activation (GO:0030449)4.45380586
35bile acid metabolic process (GO:0008206)4.40437081
36serine family amino acid catabolic process (GO:0009071)4.38262141
37homocysteine metabolic process (GO:0050667)4.36033092
38mannose metabolic process (GO:0006013)4.34515776
39GDP-mannose metabolic process (GO:0019673)4.34196827
40reverse cholesterol transport (GO:0043691)4.33971026
41plasma lipoprotein particle remodeling (GO:0034369)4.25879891
42protein-lipid complex remodeling (GO:0034368)4.25879891
43macromolecular complex remodeling (GO:0034367)4.25879891
44alpha-amino acid catabolic process (GO:1901606)4.22740609
45plasma lipoprotein particle clearance (GO:0034381)4.22194718
46regulation of cholesterol esterification (GO:0010872)4.17179998
47negative regulation of cholesterol transport (GO:0032375)4.15738685
48negative regulation of sterol transport (GO:0032372)4.15738685
49glycine metabolic process (GO:0006544)4.13522118
50valine metabolic process (GO:0006573)4.12816948
51serine family amino acid biosynthetic process (GO:0009070)4.11790967
52acylglycerol homeostasis (GO:0055090)4.08434051
53triglyceride homeostasis (GO:0070328)4.08434051
54aromatic amino acid family metabolic process (GO:0009072)4.07570362
55phospholipid efflux (GO:0033700)4.06415313
56positive regulation of gamma-delta T cell activation (GO:0046645)4.05342884
572-oxoglutarate metabolic process (GO:0006103)4.01754966
58tyrosine metabolic process (GO:0006570)4.00610587
59aspartate family amino acid catabolic process (GO:0009068)3.99271902
60adenosine receptor signaling pathway (GO:0001973)3.91090740
61cellular amino acid catabolic process (GO:0009063)3.87691633
62dicarboxylic acid biosynthetic process (GO:0043650)3.87471727
63serine family amino acid metabolic process (GO:0009069)3.86110538
64cellular ketone body metabolic process (GO:0046950)3.85691499
65acetyl-CoA metabolic process (GO:0006084)3.75200832
66regulation of cholesterol homeostasis (GO:2000188)3.72279437
67L-serine metabolic process (GO:0006563)3.69285195
68plasma lipoprotein particle assembly (GO:0034377)3.68643200
69cholesterol efflux (GO:0033344)3.68505302
70phospholipid homeostasis (GO:0055091)3.66772290
71coenzyme catabolic process (GO:0009109)3.66437465
72glutamate metabolic process (GO:0006536)3.64551903
73imidazole-containing compound metabolic process (GO:0052803)3.64357623
74cellular modified amino acid catabolic process (GO:0042219)3.62350553
75ethanol metabolic process (GO:0006067)3.59745705
76positive regulation of lipoprotein lipase activity (GO:0051006)3.59360844
77positive regulation of triglyceride lipase activity (GO:0061365)3.59360844
78fatty acid beta-oxidation (GO:0006635)3.58856324
79positive regulation of lipid catabolic process (GO:0050996)3.56157634
80fatty acid oxidation (GO:0019395)3.52373152
81low-density lipoprotein particle remodeling (GO:0034374)3.49844574
82carboxylic acid catabolic process (GO:0046395)3.48023329
83organic acid catabolic process (GO:0016054)3.48023329
84protein-lipid complex assembly (GO:0065005)3.47232137
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.47121346
86response to peptidoglycan (GO:0032494)3.45992785
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.45683038
88lipid oxidation (GO:0034440)3.44517002
89indolalkylamine metabolic process (GO:0006586)3.44509452
90cholesterol homeostasis (GO:0042632)3.44481308
91bile acid and bile salt transport (GO:0015721)3.44465938
92arginine metabolic process (GO:0006525)3.44127032
93G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.42573935
94response to muramyl dipeptide (GO:0032495)3.40351897
95benzene-containing compound metabolic process (GO:0042537)3.40223485
96complement activation (GO:0006956)3.39829182
97complement activation, classical pathway (GO:0006958)3.39722271
98fibrinolysis (GO:0042730)3.39423697
99fatty acid catabolic process (GO:0009062)3.39204034
100monocarboxylic acid catabolic process (GO:0072329)3.38093454
101sterol homeostasis (GO:0055092)3.37270940
102regulation of skeletal muscle contraction (GO:0014819)3.36432598
103plasma lipoprotein particle organization (GO:0071827)3.34441879
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34365013
105cellular biogenic amine catabolic process (GO:0042402)3.34228889
106amine catabolic process (GO:0009310)3.34228889
107carnitine metabolic process (GO:0009437)3.33238375
108primary alcohol catabolic process (GO:0034310)3.33141187
109negative regulation of cell killing (GO:0031342)3.33029024
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33029024
111purinergic nucleotide receptor signaling pathway (GO:0035590)3.32254438
112oxaloacetate metabolic process (GO:0006107)3.30487694
113negative regulation of lipase activity (GO:0060192)3.30230759
114ketone body metabolic process (GO:1902224)3.29563996
115UV protection (GO:0009650)3.28282456
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.28047239
117detection of bacterium (GO:0016045)3.26717279
118proline biosynthetic process (GO:0006561)3.18778332
119regulation of synapse structural plasticity (GO:0051823)3.17395138
120protein insertion into membrane (GO:0051205)3.09941772
121detection of other organism (GO:0098543)3.06504277
122positive thymic T cell selection (GO:0045059)3.04113565
123purinergic receptor signaling pathway (GO:0035587)3.02072572
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01726026
125antigen processing and presentation of endogenous antigen (GO:0019883)2.99164666
126negative regulation of cell size (GO:0045792)2.98948025
127granulocyte differentiation (GO:0030851)2.98843655
128positive regulation of B cell differentiation (GO:0045579)2.96668766
129regulation of cytokine production involved in inflammatory response (GO:1900015)2.96203988
1303-UTR-mediated mRNA stabilization (GO:0070935)2.94312919
131purine deoxyribonucleotide catabolic process (GO:0009155)2.93626722
132G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.93431325
133tricarboxylic acid metabolic process (GO:0072350)2.90681689
134regulation of mast cell degranulation (GO:0043304)2.90240633
135negative regulation of innate immune response (GO:0045824)2.88660561
136regulation of gamma-delta T cell activation (GO:0046643)2.87630197
137modulation by virus of host process (GO:0019054)2.86852034
138regulation of gamma-delta T cell differentiation (GO:0045586)2.84432659
139thymic T cell selection (GO:0045061)2.82982939
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76391714
141germinal center formation (GO:0002467)2.73898586
142regulation of leukocyte degranulation (GO:0043300)2.73839483
143regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71979722
144phosphatidylglycerol biosynthetic process (GO:0006655)2.71933399
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71132405
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.71132405
147modulation by symbiont of host immune response (GO:0052553)2.71132405
148positive regulation by symbiont of host defense response (GO:0052509)2.71132405
149modulation by symbiont of host defense response (GO:0052031)2.71132405
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71132405
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70305693
152regulation of cholesterol metabolic process (GO:0090181)2.70076447
153B cell receptor signaling pathway (GO:0050853)2.68107881
154negative regulation of interleukin-8 production (GO:0032717)2.65494603
155NIK/NF-kappaB signaling (GO:0038061)2.65450768
156intracellular estrogen receptor signaling pathway (GO:0030520)2.65259219
157amyloid precursor protein catabolic process (GO:0042987)2.65177817
158antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61980157
159adenine nucleotide transport (GO:0051503)2.61861125
160glycosphingolipid catabolic process (GO:0046479)2.61822321
161base-excision repair, AP site formation (GO:0006285)2.61649545
162N-acetylneuraminate metabolic process (GO:0006054)2.59964272
163amino sugar catabolic process (GO:0046348)2.58023445
164macrophage activation involved in immune response (GO:0002281)2.56725921
165regulation of interferon-beta biosynthetic process (GO:0045357)2.56512561
166chaperone mediated protein folding requiring cofactor (GO:0051085)2.56266791
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55571208
168iron-sulfur cluster assembly (GO:0016226)2.55491659
169metallo-sulfur cluster assembly (GO:0031163)2.55491659
170regulation of mast cell activation involved in immune response (GO:0033006)2.53392547
171regulation of regulated secretory pathway (GO:1903305)2.51631196
172spliceosomal tri-snRNP complex assembly (GO:0000244)2.49866884
173modulation by symbiont of host cellular process (GO:0044068)2.49212130
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48337140
175Golgi transport vesicle coating (GO:0048200)2.47899051
176COPI coating of Golgi vesicle (GO:0048205)2.47899051
177detection of external biotic stimulus (GO:0098581)2.47465986
178positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47277052
179mucosal-associated lymphoid tissue development (GO:0048537)2.47094430
180Peyers patch development (GO:0048541)2.47094430
181retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46986945
182dosage compensation (GO:0007549)2.43164346
183regulation of cholesterol biosynthetic process (GO:0045540)2.41944838
184deoxyribonucleotide catabolic process (GO:0009264)2.41019935
185neutrophil activation involved in immune response (GO:0002283)2.40889766
186cellular response to interleukin-4 (GO:0071353)2.40208547
187pentose-phosphate shunt (GO:0006098)2.38882566
188T cell selection (GO:0045058)2.38797866
189cardiolipin metabolic process (GO:0032048)2.38407350
190purine deoxyribonucleotide metabolic process (GO:0009151)2.38263648
191peptidyl-arginine omega-N-methylation (GO:0035247)2.37172378
192creatine metabolic process (GO:0006600)2.36750413
193negative regulation of leukocyte mediated immunity (GO:0002704)2.34432245
194response to misfolded protein (GO:0051788)2.34044812
195positive regulation of protein homooligomerization (GO:0032464)2.33927126
196poly(A)+ mRNA export from nucleus (GO:0016973)2.33024723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.55479950
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.51888087
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.93824523
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.07508462
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.92706715
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.74120349
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18041581
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.00557613
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.40032335
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.02868690
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45951554
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15813418
13VDR_24763502_ChIP-Seq_THP-1_Human2.15003004
14CLOCK_20551151_ChIP-Seq_293T_Human2.05022975
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96989666
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89672599
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83533305
18GATA1_22025678_ChIP-Seq_K562_Human1.79234400
19TET1_21451524_ChIP-Seq_MESCs_Mouse1.77767933
20SA1_27219007_Chip-Seq_ERYTHROID_Human1.72499986
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71952536
22CIITA_25753668_ChIP-Seq_RAJI_Human1.70641835
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.69725264
24XRN2_22483619_ChIP-Seq_HELA_Human1.68355909
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66976355
26* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65856886
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61706163
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59170844
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58825693
30* SMC4_20622854_ChIP-Seq_HELA_Human1.57655707
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54371887
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52666124
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51935390
34E2F1_20622854_ChIP-Seq_HELA_Human1.47747215
35PHF8_20622854_ChIP-Seq_HELA_Human1.47313434
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44562328
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41698102
38* MYC_22102868_ChIP-Seq_BL_Human1.40087437
39PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38978147
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38449977
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38365234
42PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37487018
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37195705
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36900767
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36725224
46* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36068755
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35563952
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.34115278
49* LXR_22292898_ChIP-Seq_THP-1_Human1.33447597
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33444645
51CREB1_26743006_Chip-Seq_LNCaP_Human1.32955600
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30990761
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30280361
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28103816
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.27301912
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27177265
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26625279
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25144515
59* CTCF_21964334_Chip-Seq_Bcells_Human1.24136363
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.24063469
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22247329
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20917244
63FOXP1_21924763_ChIP-Seq_HESCs_Human1.20808413
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20804185
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20471202
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20270408
67* SA1_27219007_Chip-Seq_Bcells_Human1.19538039
68* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18266601
69* CTCF_27219007_Chip-Seq_Bcells_Human1.18186289
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17005009
71SPI1_23547873_ChIP-Seq_NB4_Human1.16305570
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15515005
73ZNF263_19887448_ChIP-Seq_K562_Human1.14017984
74ETS1_21867929_ChIP-Seq_TH2_Mouse1.12651037
75GABP_19822575_ChIP-Seq_HepG2_Human1.12360679
76RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12128804
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12015900
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11102092
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11014708
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10785451
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08924419
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08357690
83HNF4A_19822575_ChIP-Seq_HepG2_Human1.08004651
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07722422
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.07202890
86VDR_21846776_ChIP-Seq_THP-1_Human1.07035893
87SCL_19346495_ChIP-Seq_HPC-7_Human1.06806172
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05806125
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05663330
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05532032
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05340126
92KDM2B_26808549_Chip-Seq_K562_Human1.04810843
93MAF_26560356_Chip-Seq_TH1_Human1.01247228
94GATA1_19941826_ChIP-Seq_K562_Human1.00619480
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00112872
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99256895
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98819893
98* BCL6_27268052_Chip-Seq_Bcells_Human0.97028311
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.95826586
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95167399
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91389433
102TCF7_22412390_ChIP-Seq_EML_Mouse0.90667094
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89846320
104* P68_20966046_ChIP-Seq_HELA_Human0.88432722
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87598270
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85699059
107* BCOR_27268052_Chip-Seq_Bcells_Human0.85695116
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.85064714
109UTX_26944678_Chip-Seq_JUKART_Human0.84963827
110* RARB_24833708_ChIP-Seq_LIVER_Mouse0.84713752
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.84289036
112RACK7_27058665_Chip-Seq_MCF-7_Human0.83887102
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82603721
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81769887
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81537810
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81512565
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80800417
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80730279
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80194060
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78991075
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78240349
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.78050820
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.78050820
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78017081
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77889470
126GATA4_25053715_ChIP-Seq_YYC3_Human0.77370539
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77362886
128GATA2_19941826_ChIP-Seq_K562_Human0.76897791
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76203558
130* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74165262
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73949518
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73050808
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72599552
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72368132
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.71800708
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71358069
137MYB_26560356_Chip-Seq_TH1_Human0.70496548
138MAF_26560356_Chip-Seq_TH2_Human0.70323519
139* P300_27268052_Chip-Seq_Bcells_Human0.69477034
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69337861
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.69304762
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69277533
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69132425
144CTCF_26484167_Chip-Seq_Bcells_Mouse0.67971083
145KDM2B_26808549_Chip-Seq_DND41_Human0.67786571
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67782233
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.67599508
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67463128
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.67424536
150* NCOR1_26117541_ChIP-Seq_K562_Human0.67420706
151ATF3_27146783_Chip-Seq_COLON_Human0.67405740
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67202515
153IRF8_27001747_Chip-Seq_BMDM_Mouse0.66437219
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66315522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.91655352
2MP0005360_urolithiasis6.20677431
3MP0005365_abnormal_bile_salt5.44858818
4MP0005085_abnormal_gallbladder_physiolo5.26868064
5MP0008875_abnormal_xenobiotic_pharmacok4.23171156
6MP0003806_abnormal_nucleotide_metabolis3.89503762
7MP0009840_abnormal_foam_cell3.69866017
8MP0010329_abnormal_lipoprotein_level3.35079270
9MP0001986_abnormal_taste_sensitivity3.21028436
10MP0003252_abnormal_bile_duct3.20621235
11MP0009278_abnormal_bone_marrow3.15437760
12MP0005423_abnormal_somatic_nervous3.02944516
13MP0005083_abnormal_biliary_tract2.97116227
14MP0003191_abnormal_cellular_cholesterol2.85050242
15MP0001666_abnormal_nutrient_absorption2.46250933
16MP0005332_abnormal_amino_acid2.34388062
17MP0003195_calcinosis2.28580654
18MP0000609_abnormal_liver_physiology2.23051406
19MP0008260_abnormal_autophagy2.19286655
20MP0001545_abnormal_hematopoietic_system2.17837849
21MP0005397_hematopoietic_system_phenotyp2.17837849
22MP0000751_myopathy2.08804935
23MP0002118_abnormal_lipid_homeostasis2.04931341
24MP0003656_abnormal_erythrocyte_physiolo2.03532162
25MP0004381_abnormal_hair_follicle1.92507808
26MP0005171_absent_coat_pigmentation1.84936379
27MP0005319_abnormal_enzyme/_coenzyme1.83277302
28MP0003763_abnormal_thymus_physiology1.83001236
29MP0003705_abnormal_hypodermis_morpholog1.78657974
30MP0005174_abnormal_tail_pigmentation1.78619233
31MP0004019_abnormal_vitamin_homeostasis1.76052433
32MP0004130_abnormal_muscle_cell1.65294712
33MP0005584_abnormal_enzyme/coenzyme_acti1.58951070
34MP0001764_abnormal_homeostasis1.58221364
35MP0005000_abnormal_immune_tolerance1.55621143
36MP0003724_increased_susceptibility_to1.54777163
37MP0003183_abnormal_peptide_metabolism1.49496733
38MP0002723_abnormal_immune_serum1.46346704
39MP0002420_abnormal_adaptive_immunity1.45375243
40MP0001819_abnormal_immune_cell1.44310425
41MP0005670_abnormal_white_adipose1.41321456
42MP0002138_abnormal_hepatobiliary_system1.41056693
43MP0003453_abnormal_keratinocyte_physiol1.37824299
44MP0001790_abnormal_immune_system1.37174341
45MP0005387_immune_system_phenotype1.37174341
46MP0000015_abnormal_ear_pigmentation1.36911735
47MP0002398_abnormal_bone_marrow1.36724338
48MP0002452_abnormal_antigen_presenting1.36386365
49MP0000598_abnormal_liver_morphology1.32881392
50MP0000750_abnormal_muscle_regeneration1.31728007
51MP0002148_abnormal_hypersensitivity_rea1.29400530
52MP0009333_abnormal_splenocyte_physiolog1.29336074
53MP0003868_abnormal_feces_composition1.28913604
54MP0008874_decreased_physiological_sensi1.27406872
55MP0009643_abnormal_urine_homeostasis1.26495189
56MP0003011_delayed_dark_adaptation1.22083306
57MP0000716_abnormal_immune_system1.21717641
58MP0006036_abnormal_mitochondrial_physio1.19492428
59MP0005451_abnormal_body_composition1.18110334
60MP0002822_catalepsy1.17605251
61MP0002722_abnormal_immune_system1.17567810
62MP0005058_abnormal_lysosome_morphology1.16587967
63MP0000604_amyloidosis1.15523520
64MP0002429_abnormal_blood_cell1.15265230
65MP0002132_abnormal_respiratory_system1.13956273
66MP0010155_abnormal_intestine_physiology1.13153917
67MP0000465_gastrointestinal_hemorrhage1.11204283
68MP0001968_abnormal_touch/_nociception1.10450815
69MP0004859_abnormal_synaptic_plasticity1.08858421
70MP0008469_abnormal_protein_level1.08000726
71MP0005464_abnormal_platelet_physiology1.07912957
72MP0003186_abnormal_redox_activity1.07874782
73MP0002971_abnormal_brown_adipose1.07404167
74MP0005310_abnormal_salivary_gland1.03155006
75MP0009763_increased_sensitivity_to1.02594826
76MP0002396_abnormal_hematopoietic_system1.02492211
77MP0001502_abnormal_circadian_rhythm1.02379885
78MP0001873_stomach_inflammation0.99280011
79MP0003111_abnormal_nucleus_morphology0.98506780
80MP0000703_abnormal_thymus_morphology0.97761688
81MP0005666_abnormal_adipose_tissue0.96685364
82MP0002269_muscular_atrophy0.93981473
83MP0009764_decreased_sensitivity_to0.93238987
84MP0002405_respiratory_system_inflammati0.93031678
85MP0000747_muscle_weakness0.92397767
86MP0005501_abnormal_skin_physiology0.90133230
87MP0009642_abnormal_blood_homeostasis0.89805964
88MP0001533_abnormal_skeleton_physiology0.88252557
89MP0000358_abnormal_cell_content/0.87876950
90MP0002078_abnormal_glucose_homeostasis0.87370779
91MP0005076_abnormal_cell_differentiation0.86003292
92MP0003436_decreased_susceptibility_to0.85177637
93MP0004808_abnormal_hematopoietic_stem0.84019164
94MP0004947_skin_inflammation0.83448775
95MP0002019_abnormal_tumor_incidence0.82362854
96MP0009931_abnormal_skin_appearance0.82074932
97MP0005636_abnormal_mineral_homeostasis0.81432347
98MP0005647_abnormal_sex_gland0.79731549
99MP0002638_abnormal_pupillary_reflex0.79057386
100MP0005075_abnormal_melanosome_morpholog0.76570280
101MP0005266_abnormal_metabolism0.74196836
102MP0003300_gastrointestinal_ulcer0.74138213
103MP0001346_abnormal_lacrimal_gland0.73317270
104MP0005334_abnormal_fat_pad0.73234432
105MP0006035_abnormal_mitochondrial_morpho0.72909430
106MP0010368_abnormal_lymphatic_system0.72433085
107MP0000858_altered_metastatic_potential0.72118248
108MP0005376_homeostasis/metabolism_phenot0.72015654
109MP0000685_abnormal_immune_system0.71670719
110MP0002837_dystrophic_cardiac_calcinosis0.71090220
111MP0005671_abnormal_response_to0.70724243
112MP0004185_abnormal_adipocyte_glucose0.70246415
113MP0006082_CNS_inflammation0.69764650
114MP0004036_abnormal_muscle_relaxation0.69636477
115MP0009765_abnormal_xenobiotic_induced0.68647197
116MP0008961_abnormal_basal_metabolism0.68572524
117MP0003690_abnormal_glial_cell0.67080392
118MP0005220_abnormal_exocrine_pancreas0.66768177
119MP0002254_reproductive_system_inflammat0.66705444
120MP0001845_abnormal_inflammatory_respons0.66370570
121MP0003329_amyloid_beta_deposits0.64819536
122MP0003172_abnormal_lysosome_physiology0.64036516
123MP0009697_abnormal_copulation0.63922265
124MP0001853_heart_inflammation0.63572913
125MP0002166_altered_tumor_susceptibility0.63311547
126MP0000749_muscle_degeneration0.62975590
127MP0001661_extended_life_span0.61358738
128MP0005375_adipose_tissue_phenotype0.60689008
129MP0001756_abnormal_urination0.59067411
130MP0005330_cardiomyopathy0.58584540
131MP0005535_abnormal_body_temperature0.58571140
132MP0001835_abnormal_antigen_presentation0.58319566
133MP0004147_increased_porphyrin_level0.58074125
134MP0004087_abnormal_muscle_fiber0.57836213
135MP0001243_abnormal_dermal_layer0.57600521
136MP0005025_abnormal_response_to0.57314732
137MP0002970_abnormal_white_adipose0.57166725
138MP0009115_abnormal_fat_cell0.55667879
139MP0002136_abnormal_kidney_physiology0.55188777
140MP0005448_abnormal_energy_balance0.55034937
141MP0001800_abnormal_humoral_immune0.54888156
142MP0008873_increased_physiological_sensi0.54873127
143MP0009785_altered_susceptibility_to0.54100515
144MP0002876_abnormal_thyroid_physiology0.52587846
145MP0009672_abnormal_birth_weight0.51097180
146MP0002419_abnormal_innate_immunity0.49742819
147MP0001849_ear_inflammation0.49613350
148MP0005408_hypopigmentation0.47348070
149MP0000249_abnormal_blood_vessel0.44928168
150MP0003646_muscle_fatigue0.44275772
151MP0003303_peritoneal_inflammation0.43719958
152MP0000689_abnormal_spleen_morphology0.43482774
153MP0003075_altered_response_to0.41394256
154MP0003221_abnormal_cardiomyocyte_apopto0.41371531
155MP0005166_decreased_susceptibility_to0.41368604

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.39110589
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.96891983
3Intrahepatic cholestasis (HP:0001406)5.66727378
4Hypobetalipoproteinemia (HP:0003563)5.42144486
5Xanthomatosis (HP:0000991)5.36432188
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.34010719
7Prolonged partial thromboplastin time (HP:0003645)4.91863130
8Hyperlipoproteinemia (HP:0010980)4.68821930
9Complement deficiency (HP:0004431)4.59405581
10Hypolipoproteinemia (HP:0010981)4.17580910
11Ketosis (HP:0001946)4.07060990
12Hyperammonemia (HP:0001987)4.06275630
13Ragged-red muscle fibers (HP:0003200)3.93309316
14Testicular atrophy (HP:0000029)3.93304846
15Abnormality of the common coagulation pathway (HP:0010990)3.85244419
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.82315218
17Joint hemorrhage (HP:0005261)3.70148817
18Hypoalphalipoproteinemia (HP:0003233)3.69976705
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.69201806
20Hypoglycemic coma (HP:0001325)3.66773719
21Abnormality of fatty-acid metabolism (HP:0004359)3.54729965
22Epidermoid cyst (HP:0200040)3.53510911
23Thin bony cortex (HP:0002753)3.43378178
24Abnormality of methionine metabolism (HP:0010901)3.37289498
25Annular pancreas (HP:0001734)3.36848316
26Abnormality of complement system (HP:0005339)3.36824636
27Myopathic facies (HP:0002058)3.36170968
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34751005
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28908674
30Abnormality of the intrinsic pathway (HP:0010989)3.28730462
31Hypercholesterolemia (HP:0003124)3.25779011
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25203586
33Abnormality of serine family amino acid metabolism (HP:0010894)3.21259028
34Abnormality of glycine metabolism (HP:0010895)3.21259028
35Ketoacidosis (HP:0001993)3.19706422
36Fat malabsorption (HP:0002630)3.18872164
37Hyperglycinuria (HP:0003108)3.13228382
38Eczematoid dermatitis (HP:0000976)3.08646064
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06343582
40Akinesia (HP:0002304)3.05809980
41Fetal akinesia sequence (HP:0001989)3.02412034
42Hyperglycinemia (HP:0002154)3.00215702
43Dyschromatopsia (HP:0007641)2.96813577
44Abnormality of pyrimidine metabolism (HP:0004353)2.94457052
45Hyperbilirubinemia (HP:0002904)2.91608385
46Poikiloderma (HP:0001029)2.90967173
47Mesangial abnormality (HP:0001966)2.85260752
48Myoglobinuria (HP:0002913)2.84328185
49Myocardial infarction (HP:0001658)2.81435391
50Cholelithiasis (HP:0001081)2.80150601
51Dysostosis multiplex (HP:0000943)2.79362911
52Ankle clonus (HP:0011448)2.77312731
53Abnormal gallbladder morphology (HP:0012437)2.71616404
54Recurrent abscess formation (HP:0002722)2.71360373
55Increased cerebral lipofuscin (HP:0011813)2.70264357
56Abnormality of polysaccharide metabolism (HP:0011012)2.68665111
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68665111
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68665111
59Abnormality of nucleobase metabolism (HP:0010932)2.66386682
60Increased muscle lipid content (HP:0009058)2.66123633
61Gout (HP:0001997)2.65725763
62Mucopolysacchariduria (HP:0008155)2.63201515
63Urinary glycosaminoglycan excretion (HP:0003541)2.63201515
64Hepatocellular carcinoma (HP:0001402)2.59532693
65Obstructive lung disease (HP:0006536)2.59193192
66Chronic obstructive pulmonary disease (HP:0006510)2.59193192
67Anteriorly placed anus (HP:0001545)2.58244416
68Exercise-induced myalgia (HP:0003738)2.56470918
69Systemic lupus erythematosus (HP:0002725)2.55877947
70Cholecystitis (HP:0001082)2.54293160
71Abnormal gallbladder physiology (HP:0012438)2.54293160
72Mitral stenosis (HP:0001718)2.53470931
73Petechiae (HP:0000967)2.53300181
74Facial diplegia (HP:0001349)2.53013616
75Abnormality of purine metabolism (HP:0004352)2.52351497
76Exercise-induced muscle cramps (HP:0003710)2.50787505
77Dicarboxylic aciduria (HP:0003215)2.50765224
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50765224
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50526917
80Easy fatigability (HP:0003388)2.49077146
81Abnormality of glycolipid metabolism (HP:0010969)2.45939224
82Abnormality of liposaccharide metabolism (HP:0010968)2.45939224
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.45939224
84Steatorrhea (HP:0002570)2.45231166
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.44773134
86Increased intramyocellular lipid droplets (HP:0012240)2.44352776
87Conjugated hyperbilirubinemia (HP:0002908)2.44150912
88Rhabdomyolysis (HP:0003201)2.44042456
89Skin nodule (HP:0200036)2.40971829
90Recurrent bacterial skin infections (HP:0005406)2.40605413
91Metabolic acidosis (HP:0001942)2.40411683
92Facial hemangioma (HP:0000329)2.39667277
93Spastic diplegia (HP:0001264)2.39653004
94Squamous cell carcinoma (HP:0002860)2.38400945
95Colitis (HP:0002583)2.38331426
96Late onset (HP:0003584)2.36447884
97Cellulitis (HP:0100658)2.35699042
98Hypertensive crisis (HP:0100735)2.32946247
99Acanthocytosis (HP:0001927)2.29648348
100Ulnar bowing (HP:0003031)2.29206897
101Rib fusion (HP:0000902)2.28719121
102Agammaglobulinemia (HP:0004432)2.27273390
103Neuronal loss in central nervous system (HP:0002529)2.24890733
104Vascular calcification (HP:0004934)2.24162486
105Turricephaly (HP:0000262)2.23983207
106Gingival bleeding (HP:0000225)2.22403683
107Abnormality of serum amino acid levels (HP:0003112)2.21849202
108Basal cell carcinoma (HP:0002671)2.21612329
109Joint stiffness (HP:0001387)2.20888480
110Microvesicular hepatic steatosis (HP:0001414)2.20194198
111Spontaneous abortion (HP:0005268)2.19495065
112Elevated erythrocyte sedimentation rate (HP:0003565)2.17535656
113Abnormality of macrophages (HP:0004311)2.15598660
114Abnormality of the gallbladder (HP:0005264)2.14704404
115Recurrent gram-negative bacterial infections (HP:0005420)2.14434225
116Panhypogammaglobulinemia (HP:0003139)2.12802648
117Neonatal onset (HP:0003623)2.12140951
118Nonimmune hydrops fetalis (HP:0001790)2.10905537
119Thrombophlebitis (HP:0004418)2.10235603
120Progressive muscle weakness (HP:0003323)2.09496042
121Hypoglycemic seizures (HP:0002173)2.09482416
122Stridor (HP:0010307)2.09354548
123Poikilocytosis (HP:0004447)2.08234089
124Recurrent fungal infections (HP:0002841)2.08013475
125Hemorrhage of the eye (HP:0011885)2.07376398
126Centrally nucleated skeletal muscle fibers (HP:0003687)2.07151879
127Abnormality of iron homeostasis (HP:0011031)2.06421884
128Increased IgE level (HP:0003212)2.05821757
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05545314
130Chronic mucocutaneous candidiasis (HP:0002728)2.05011270
131Recurrent cutaneous fungal infections (HP:0011370)2.05011270
132Lethargy (HP:0001254)2.04556686
133Progressive external ophthalmoplegia (HP:0000590)2.03973478
134Mediastinal lymphadenopathy (HP:0100721)2.03692938
135Upper motor neuron abnormality (HP:0002127)2.03285085
136Meningitis (HP:0001287)2.02880275
137Seborrheic dermatitis (HP:0001051)2.01415185
138Popliteal pterygium (HP:0009756)2.01029474
139Reticulocytosis (HP:0001923)2.00981767
140Cardiovascular calcification (HP:0011915)2.00515576
141Myositis (HP:0100614)2.00355859
142Brushfield spots (HP:0001088)1.98131430
143Delayed CNS myelination (HP:0002188)1.97195574
144Abnormality of the heme biosynthetic pathway (HP:0010472)1.96419832
145Abnormality of transition element cation homeostasis (HP:0011030)1.96017171
146Pustule (HP:0200039)1.95672581
147Vaginal fistula (HP:0004320)1.95073707
148Amyloidosis (HP:0011034)1.94330783
149Upper limb amyotrophy (HP:0009129)1.93669238
150Distal upper limb amyotrophy (HP:0007149)1.93669238
151Asymmetric septal hypertrophy (HP:0001670)1.92335002
152Epistaxis (HP:0000421)1.91655963
153Rapidly progressive (HP:0003678)1.91545457
154Generalized aminoaciduria (HP:0002909)1.91499245
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91440591
156Esophageal varix (HP:0002040)1.91162670
157Hyporeflexia of lower limbs (HP:0002600)1.90572248
158Respiratory difficulties (HP:0002880)1.90038835
159Hand muscle atrophy (HP:0009130)1.89824395
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89674105
161Muscle fiber inclusion bodies (HP:0100299)1.89013761
162Pancreatitis (HP:0001733)1.88720790
163Progressive microcephaly (HP:0000253)1.88197418
164Irritability (HP:0000737)1.87529612
165Gastrointestinal inflammation (HP:0004386)1.87322603
166Widely patent fontanelles and sutures (HP:0004492)1.87114535
167Recurrent skin infections (HP:0001581)1.86840138
168Increased serum ferritin (HP:0003281)1.85620200
169Polycythemia (HP:0001901)1.84395911
170Gastrointestinal dysmotility (HP:0002579)1.83717501
171Delayed epiphyseal ossification (HP:0002663)1.83294813
172Diminished movement (HP:0002374)1.82880668
173Sensorimotor neuropathy (HP:0007141)1.82734563
174Hypertriglyceridemia (HP:0002155)1.82307535
175Abnormal cartilage morphology (HP:0002763)1.80785272
176Stroke (HP:0001297)1.80188911
177Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80056934
178Purpura (HP:0000979)1.79678784
179Glomerulonephritis (HP:0000099)1.78376143
180Abnormality of the pancreatic islet cells (HP:0006476)1.78248498
181Abnormality of endocrine pancreas physiology (HP:0012093)1.78248498
182Opisthotonus (HP:0002179)1.77803334
183Increased purine levels (HP:0004368)1.76573871
184Hyperuricemia (HP:0002149)1.76573871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.09385996
2ERN14.31982610
3TRIB34.25654180
4PRPF4B3.91157850
5SIK13.69338828
6FGFR43.48705688
7PKN23.12952721
8MAPK152.67746151
9MAP4K12.42094730
10RIPK42.40756415
11TAOK32.33216405
12EEF2K2.29929795
13TTN2.27196283
14SMG12.12620086
15MAP3K102.03217081
16TYK22.02011962
17TNK21.93676406
18EPHA31.86550674
19MAP2K31.85886336
20FES1.66032225
21PDK31.61198501
22PDK41.61198501
23PTK61.60076782
24ZAP701.59652583
25MAP3K71.56475014
26NME21.48944823
27PIK3CG1.46347937
28MUSK1.45793795
29TBK11.45074745
30EPHB11.42673939
31MARK21.37646023
32MAPK111.36961382
33BLK1.32835160
34OBSCN1.31957959
35TAOK21.29195883
36LRRK21.27463672
37FLT31.25545241
38KDR1.22657061
39JAK11.16636844
40NEK11.16251145
41STK101.13404343
42IRAK41.08439270
43PIM21.07271335
44JAK21.05156418
45PRKD21.03695318
46GRK61.02754150
47PRKD31.01503063
48TGFBR21.00652800
49INSRR0.97407215
50KIT0.96652943
51BRD40.94754850
52FGFR20.93477247
53RIPK10.93281017
54TESK20.93250736
55IRAK20.91940826
56CSF1R0.91137566
57MAP3K30.89116931
58KSR20.86081544
59ICK0.84555920
60STK160.84396683
61NEK90.83341040
62MAP2K20.83340221
63CAMKK10.82472207
64MAPK120.81182154
65MAP3K10.80303184
66IKBKB0.79683735
67ITK0.78981425
68PAK60.77588064
69BTK0.77509667
70PDK20.75994124
71RPS6KA20.73737893
72TIE10.73258272
73PRKAA20.72092913
74DAPK20.70381373
75ERBB40.68610692
76RPS6KC10.65964941
77RPS6KL10.65964941
78IKBKE0.65585554
79JAK30.65539583
80TXK0.64737217
81DAPK10.64616122
82SIK20.64325345
83MAP3K110.64094394
84SGK30.62582812
85CDK40.61613149
86MTOR0.58590130
87SYK0.57325101
88NEK60.57122753
89FGFR30.56900642
90CSK0.56561792
91MAP2K60.56424250
92DYRK1B0.53758890
93CDK190.53535329
94MARK30.53428624
95MAP3K60.52525154
96CAMK1D0.52064593
97PRKCH0.51647502
98RET0.51568536
99PRKAA10.50717120
100HCK0.50496585
101GRK10.50101378
102HIPK20.49822969
103ERBB20.49726262
104PRKD10.49628880
105PDGFRA0.49161017
106MATK0.48444612
107* LYN0.48177732
108CDK60.48065633
109BMX0.47137851
110RPS6KA60.46590045
111MAPK70.46319124
112RAF10.45796288
113MST1R0.45685640
114MAPKAPK50.44825723
115PASK0.44215264
116SIK30.43441034
117LCK0.43370291
118PAK40.43221509
119MAPK40.43198730
120PHKG20.42656832
121PHKG10.42656832
122MAP3K140.42293627
123PDK10.41577111
124MAP3K130.41557391
125RPS6KA40.41244956
126RPS6KA10.40495118
127AURKA0.39778102
128ILK0.38928458
129TAOK10.38740864
130MAP2K40.38285438
131RPS6KA50.38134422
132FGFR10.37894579
133PDPK10.37123729
134TESK10.36075236
135CCNB10.35331478
136MAP3K80.35188817
137MAPKAPK30.34600814
138PINK10.34503261
139RPS6KB20.33807964
140PRKACG0.32527819
141PAK20.31434890
142MAP2K10.29449732
143SCYL20.26891202
144IRAK30.26716882

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14392568
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.70621640
3Nitrogen metabolism_Homo sapiens_hsa009103.28638865
4Arginine biosynthesis_Homo sapiens_hsa002202.88646743
5Fatty acid degradation_Homo sapiens_hsa000712.83436207
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78206487
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72250694
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71251854
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54433727
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50635269
11Tryptophan metabolism_Homo sapiens_hsa003802.47926161
12Complement and coagulation cascades_Homo sapiens_hsa046102.46420105
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35877553
14Propanoate metabolism_Homo sapiens_hsa006402.27792795
15Fatty acid metabolism_Homo sapiens_hsa012122.11090385
16Caffeine metabolism_Homo sapiens_hsa002321.96259655
17PPAR signaling pathway_Homo sapiens_hsa033201.94925317
18Peroxisome_Homo sapiens_hsa041461.91290772
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89588724
20Butanoate metabolism_Homo sapiens_hsa006501.84408164
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.82350331
22Staphylococcus aureus infection_Homo sapiens_hsa051501.74652300
23Biosynthesis of amino acids_Homo sapiens_hsa012301.73970010
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72664469
25Pyruvate metabolism_Homo sapiens_hsa006201.72316690
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71504063
27Carbon metabolism_Homo sapiens_hsa012001.71419873
28Base excision repair_Homo sapiens_hsa034101.68997581
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68666231
30Selenocompound metabolism_Homo sapiens_hsa004501.67725101
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66692998
32Histidine metabolism_Homo sapiens_hsa003401.66331003
33beta-Alanine metabolism_Homo sapiens_hsa004101.62432940
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.61070132
35Chemical carcinogenesis_Homo sapiens_hsa052041.57446064
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56443706
37Phenylalanine metabolism_Homo sapiens_hsa003601.53177389
38Fatty acid elongation_Homo sapiens_hsa000621.51644840
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51483227
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47386392
41VEGF signaling pathway_Homo sapiens_hsa043701.47111601
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.45064416
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40384852
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.39545151
45Osteoclast differentiation_Homo sapiens_hsa043801.39489598
46Retinol metabolism_Homo sapiens_hsa008301.33651319
47Leishmaniasis_Homo sapiens_hsa051401.30993888
48Tyrosine metabolism_Homo sapiens_hsa003501.30807841
49mTOR signaling pathway_Homo sapiens_hsa041501.25283436
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25215561
51Tuberculosis_Homo sapiens_hsa051521.24453238
52Fat digestion and absorption_Homo sapiens_hsa049751.21962839
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20533249
54Bile secretion_Homo sapiens_hsa049761.19571524
55ABC transporters_Homo sapiens_hsa020101.17751292
56Non-small cell lung cancer_Homo sapiens_hsa052231.16371512
57Starch and sucrose metabolism_Homo sapiens_hsa005001.15801151
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15013759
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14423494
60Folate biosynthesis_Homo sapiens_hsa007901.12604272
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.12154502
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11846187
63Pentose phosphate pathway_Homo sapiens_hsa000301.11189341
64Sphingolipid metabolism_Homo sapiens_hsa006001.09503567
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.01949091
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01682393
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98232563
68Vitamin B6 metabolism_Homo sapiens_hsa007500.98172117
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97870988
70Sulfur relay system_Homo sapiens_hsa041220.95248633
71Sulfur metabolism_Homo sapiens_hsa009200.93948134
72Lysine degradation_Homo sapiens_hsa003100.91492103
73Steroid biosynthesis_Homo sapiens_hsa001000.86708216
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85947543
75Glycerolipid metabolism_Homo sapiens_hsa005610.85933895
76Chronic myeloid leukemia_Homo sapiens_hsa052200.85926959
77Arginine and proline metabolism_Homo sapiens_hsa003300.83744764
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82594294
79Hepatitis B_Homo sapiens_hsa051610.81901994
80Synaptic vesicle cycle_Homo sapiens_hsa047210.78271274
81Inositol phosphate metabolism_Homo sapiens_hsa005620.77578464
82One carbon pool by folate_Homo sapiens_hsa006700.76603248
83Apoptosis_Homo sapiens_hsa042100.76451350
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76276659
85Herpes simplex infection_Homo sapiens_hsa051680.75348915
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75152587
87Vitamin digestion and absorption_Homo sapiens_hsa049770.71754349
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71043966
89* Endocytosis_Homo sapiens_hsa041440.70637940
90Influenza A_Homo sapiens_hsa051640.69381270
91Notch signaling pathway_Homo sapiens_hsa043300.68915623
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.68638536
93GnRH signaling pathway_Homo sapiens_hsa049120.65719781
94Insulin resistance_Homo sapiens_hsa049310.62656368
95Allograft rejection_Homo sapiens_hsa053300.61837115
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.61157111
97Bladder cancer_Homo sapiens_hsa052190.59901968
98Shigellosis_Homo sapiens_hsa051310.59524275
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.59264250
100Fatty acid biosynthesis_Homo sapiens_hsa000610.59168159
101Pertussis_Homo sapiens_hsa051330.59067457
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58854148
103Chemokine signaling pathway_Homo sapiens_hsa040620.56103262
104Endometrial cancer_Homo sapiens_hsa052130.54970417
105Fructose and mannose metabolism_Homo sapiens_hsa000510.54398137
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.54337201
107Choline metabolism in cancer_Homo sapiens_hsa052310.53175043
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.53111476
109Pancreatic cancer_Homo sapiens_hsa052120.51865635
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51585651
111T cell receptor signaling pathway_Homo sapiens_hsa046600.50742865
112Viral carcinogenesis_Homo sapiens_hsa052030.50630697
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49651381
114Phagosome_Homo sapiens_hsa041450.47362688
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47331069
116Toxoplasmosis_Homo sapiens_hsa051450.47101081
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45901304
118Glutathione metabolism_Homo sapiens_hsa004800.43583325
119Salmonella infection_Homo sapiens_hsa051320.42390495
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.42289076
121Prolactin signaling pathway_Homo sapiens_hsa049170.42020620
122Autoimmune thyroid disease_Homo sapiens_hsa053200.41629614
123Epstein-Barr virus infection_Homo sapiens_hsa051690.41240354
124Viral myocarditis_Homo sapiens_hsa054160.38403712
125ErbB signaling pathway_Homo sapiens_hsa040120.38381253
126Metabolic pathways_Homo sapiens_hsa011000.38044534
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37897783
128Galactose metabolism_Homo sapiens_hsa000520.36748129
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.35832652
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34780313
131Glucagon signaling pathway_Homo sapiens_hsa049220.32530900
132AMPK signaling pathway_Homo sapiens_hsa041520.31284942
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.21324560
134Prion diseases_Homo sapiens_hsa050200.19868329
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19197589
136Insulin signaling pathway_Homo sapiens_hsa049100.15173892
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13483828
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.13251733
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12518269
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10801884
141Primary immunodeficiency_Homo sapiens_hsa053400.08786881
142Legionellosis_Homo sapiens_hsa051340.08415362
143Other glycan degradation_Homo sapiens_hsa005110.05662110
144Linoleic acid metabolism_Homo sapiens_hsa005910.04998226
145Lysosome_Homo sapiens_hsa041420.04460623
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.00521929
147Amoebiasis_Homo sapiens_hsa05146-0.1525502
148Regulation of autophagy_Homo sapiens_hsa04140-0.1519742
149B cell receptor signaling pathway_Homo sapiens_hsa04662-0.1362958
150Acute myeloid leukemia_Homo sapiens_hsa05221-0.1150486
151Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1112606
152Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1109617
153Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0736661
154Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0684823
155Hepatitis C_Homo sapiens_hsa05160-0.0548248
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0494859
157Antigen processing and presentation_Homo sapiens_hsa04612-0.0422821
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0017313

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »