ARFGAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.18956372
2COPI coating of Golgi vesicle (GO:0048205)8.18956372
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.33300142
4protein retention in ER lumen (GO:0006621)6.82564689
5intestinal cholesterol absorption (GO:0030299)5.86531096
6COPII vesicle coating (GO:0048208)5.73653677
7signal peptide processing (GO:0006465)5.45569726
8exocrine pancreas development (GO:0031017)5.43019904
9proline biosynthetic process (GO:0006561)5.33697190
10protein maturation by protein folding (GO:0022417)5.07942914
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.81704779
12GDP-mannose metabolic process (GO:0019673)4.73615673
13ER overload response (GO:0006983)4.71544868
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.70696163
15endocrine pancreas development (GO:0031018)4.53968311
16regulation of vitamin D biosynthetic process (GO:0060556)4.50280385
17positive regulation of nuclease activity (GO:0032075)4.49842837
18ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.46025413
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.44864407
20peptide hormone processing (GO:0016486)4.11331463
21endoplasmic reticulum unfolded protein response (GO:0030968)4.11302319
22regulation of vitamin metabolic process (GO:0030656)4.08360961
23regulation of nuclease activity (GO:0032069)4.03220842
24regulation of cytokine secretion involved in immune response (GO:0002739)4.01634965
25cellular response to unfolded protein (GO:0034620)4.01247724
26intestinal absorption (GO:0050892)3.92548287
27cellular response to ATP (GO:0071318)3.86317246
28vesicle coating (GO:0006901)3.86169223
29cellular response to topologically incorrect protein (GO:0035967)3.83008435
30positive regulation of heat generation (GO:0031652)3.82424224
31nucleotide-sugar biosynthetic process (GO:0009226)3.81901021
32sequestering of metal ion (GO:0051238)3.77717250
33ER-nucleus signaling pathway (GO:0006984)3.77592430
34response to endoplasmic reticulum stress (GO:0034976)3.77113889
35regulation of fever generation (GO:0031620)3.76249854
36proline metabolic process (GO:0006560)3.67238503
37glandular epithelial cell differentiation (GO:0002067)3.64395969
38peptidyl-proline hydroxylation (GO:0019511)3.57179473
39intestinal epithelial cell development (GO:0060576)3.53218782
40protein N-linked glycosylation via asparagine (GO:0018279)3.52029564
41peptidyl-asparagine modification (GO:0018196)3.48465626
42digestion (GO:0007586)3.41703545
43regulation of type B pancreatic cell apoptotic process (GO:2000674)3.40358101
44regulation of mononuclear cell migration (GO:0071675)3.36712479
45columnar/cuboidal epithelial cell development (GO:0002066)3.26484670
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.23822119
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.23247255
48protein N-linked glycosylation (GO:0006487)3.23058585
49response to unfolded protein (GO:0006986)3.19527390
50positive regulation of chemokine biosynthetic process (GO:0045080)3.19018271
51negative regulation of interleukin-12 production (GO:0032695)3.17737488
52ER to Golgi vesicle-mediated transport (GO:0006888)3.15400236
53regulation of heat generation (GO:0031650)3.13177734
544-hydroxyproline metabolic process (GO:0019471)3.12416803
55glandular epithelial cell development (GO:0002068)3.12136902
56zinc ion transport (GO:0006829)3.11500950
57piRNA metabolic process (GO:0034587)3.09196274
58response to topologically incorrect protein (GO:0035966)3.04641981
59eosinophil chemotaxis (GO:0048245)3.04269017
60regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03434139
61cell adhesion mediated by integrin (GO:0033627)2.98093628
62cell redox homeostasis (GO:0045454)2.95734683
63transcytosis (GO:0045056)2.92026240
64regulation of podosome assembly (GO:0071801)2.89133478
65cellular response to vitamin D (GO:0071305)2.88529512
66membrane lipid catabolic process (GO:0046466)2.88012290
67macroautophagy (GO:0016236)2.87791211
68cellular zinc ion homeostasis (GO:0006882)2.87317010
69regulation of immunoglobulin secretion (GO:0051023)2.86425323
70UDP-N-acetylglucosamine metabolic process (GO:0006047)2.86394627
71glycolipid catabolic process (GO:0019377)2.85791927
72toxin metabolic process (GO:0009404)2.85751930
73interleukin-6-mediated signaling pathway (GO:0070102)2.85066422
74nucleotide-sugar metabolic process (GO:0009225)2.82037938
75intra-Golgi vesicle-mediated transport (GO:0006891)2.77959153
76virion attachment to host cell (GO:0019062)2.76758484
77adhesion of symbiont to host cell (GO:0044650)2.76758484
78negative regulation of glycogen biosynthetic process (GO:0045719)2.76206548
79fucose metabolic process (GO:0006004)2.74474512
80cellular response to antibiotic (GO:0071236)2.74363973
81glycosphingolipid catabolic process (GO:0046479)2.73629255
82establishment of apical/basal cell polarity (GO:0035089)2.73267472
83regulation of chemokine biosynthetic process (GO:0045073)2.70310544
84Golgi organization (GO:0007030)2.70016023
85oligosaccharide catabolic process (GO:0009313)2.66420445
86protein localization to endosome (GO:0036010)2.65757289
87eosinophil migration (GO:0072677)2.64342729
88sphingolipid catabolic process (GO:0030149)2.63985086
89positive regulation of calcium ion import (GO:0090280)2.62979854
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62353359
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.61969056
92positive regulation of NF-kappaB import into nucleus (GO:0042346)2.60084148
93protein hydroxylation (GO:0018126)2.57913999
94ceramide catabolic process (GO:0046514)2.56676844
95type B pancreatic cell development (GO:0003323)2.56030102
963-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55969847
97purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55969847
98negative regulation of lipid storage (GO:0010888)2.55844074
99response to peptidoglycan (GO:0032494)2.55198208
100regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.55052478
101negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53636201
102response to hyperoxia (GO:0055093)2.52184866
103response to increased oxygen levels (GO:0036296)2.52184866
104negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51996807
105keratan sulfate catabolic process (GO:0042340)2.51834991
106T-helper 1 type immune response (GO:0042088)2.50432405
107N-glycan processing (GO:0006491)2.49577058
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49516990
109nucleotide transmembrane transport (GO:1901679)2.49473585
110maintenance of protein localization in organelle (GO:0072595)2.47068080
111positive regulation of nitric oxide biosynthetic process (GO:0045429)2.46378116
112mitotic cell cycle arrest (GO:0071850)2.45714079
113detection of molecule of bacterial origin (GO:0032490)2.44819033
114fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.44455363
115establishment of monopolar cell polarity (GO:0061162)2.43839404
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.43839404
117positive regulation of insulin secretion (GO:0032024)2.43423905
118neutrophil mediated immunity (GO:0002446)2.43037597
119regulation of nitric oxide biosynthetic process (GO:0045428)2.42887190
120cellular response to vitamin (GO:0071295)2.42034421
121chondrocyte development (GO:0002063)2.41534959
122regulation of chronic inflammatory response (GO:0002676)2.41366836
123regulation of T-helper 1 cell differentiation (GO:0045625)2.40935335
124protein localization to Golgi apparatus (GO:0034067)2.39399418
125monocyte chemotaxis (GO:0002548)2.39104702
126regulation of heterotypic cell-cell adhesion (GO:0034114)2.35602882
127sphingosine metabolic process (GO:0006670)2.35288395
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35020323
129regulation of NF-kappaB import into nucleus (GO:0042345)2.34867604
130sperm capacitation (GO:0048240)2.34514185
131Golgi vesicle transport (GO:0048193)2.34297007
132negative regulation of nitric oxide biosynthetic process (GO:0045019)2.34116288
133adhesion of symbiont to host (GO:0044406)2.32903772
134cellular response to lipopolysaccharide (GO:0071222)2.32734259
135angiotensin maturation (GO:0002003)2.32122210
136regulation of interleukin-8 biosynthetic process (GO:0045414)2.31896369
137pyrimidine-containing compound transmembrane transport (GO:0072531)2.31436896
138astrocyte differentiation (GO:0048708)2.31018597
139positive regulation of interleukin-6 production (GO:0032755)2.30717372
140mitochondrial calcium ion transport (GO:0006851)2.30581620
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30005001
142peptide secretion (GO:0002790)2.29717775
143regulation of metalloenzyme activity (GO:0048552)2.29527581
144insulin secretion (GO:0030073)2.28529593
145positive regulation of acute inflammatory response (GO:0002675)2.28492123
146zinc ion transmembrane transport (GO:0071577)2.25984033
147cellular response to type I interferon (GO:0071357)2.25836896
148type I interferon signaling pathway (GO:0060337)2.25836896
149positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.25278472
150membrane protein ectodomain proteolysis (GO:0006509)2.24325248
151neuron fate specification (GO:0048665)2.23902687
152regulation of vascular endothelial growth factor production (GO:0010574)2.23357123
153asymmetric protein localization (GO:0008105)2.23351878
154cellular response to ethanol (GO:0071361)2.23274665
155peptide hormone secretion (GO:0030072)2.22822515
156negative regulation of insulin secretion (GO:0046676)2.22644498
157cellular response to molecule of bacterial origin (GO:0071219)2.22204453
158alkaloid metabolic process (GO:0009820)2.21633086
159negative regulation of glycogen metabolic process (GO:0070874)2.21489368
160regulation of hydrogen peroxide-induced cell death (GO:1903205)2.20925848
161peptide metabolic process (GO:0006518)2.20441707
162vasodilation (GO:0042311)2.19886930
163acute-phase response (GO:0006953)2.19674155
164cellular response to toxic substance (GO:0097237)2.19416746
165branching involved in labyrinthine layer morphogenesis (GO:0060670)2.18861562
166response to type I interferon (GO:0034340)2.18695012
167regulation of insulin secretion (GO:0050796)2.17348216
168response to testosterone (GO:0033574)2.16772427
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.16725372
170regulation of integrin-mediated signaling pathway (GO:2001044)2.16625696
171vesicle targeting (GO:0006903)2.16448945
172sequestering of extracellular ligand from receptor (GO:0035581)2.16250929
173negative regulation of glucose import (GO:0046325)2.16121122
174NIK/NF-kappaB signaling (GO:0038061)2.14909339
175negative regulation of complement activation (GO:0045916)2.14480861
176germinal center formation (GO:0002467)2.13809134
177decidualization (GO:0046697)2.13545776
178response to lipoprotein particle (GO:0055094)2.10607122
179regulation of prostaglandin secretion (GO:0032306)2.10165796
180positive regulation vascular endothelial growth factor production (GO:0010575)2.09088915
181membrane protein intracellular domain proteolysis (GO:0031293)2.08515771
182diol metabolic process (GO:0034311)2.05658612
183peptide catabolic process (GO:0043171)2.04771276
184cell wall macromolecule catabolic process (GO:0016998)2.04631553
185negative regulation of protein activation cascade (GO:2000258)2.03790993
186sphingomyelin metabolic process (GO:0006684)2.03554466
187negative regulation of glucose transport (GO:0010829)2.03499228
188regulation of inflammatory response to antigenic stimulus (GO:0002861)2.02393501
189negative regulation of cytokine production involved in immune response (GO:0002719)2.02082818
190negative regulation of cytokine secretion (GO:0050710)2.01903269
191regulation of monocyte chemotaxis (GO:0090025)2.00505668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human4.05624216
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.38535094
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33744320
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.20133938
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.93477066
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76911712
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.64048345
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.39017933
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37467076
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27075576
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.21876244
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.13870874
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.11228265
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02594492
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02225468
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00940438
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.99278365
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97887343
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94630955
20SOX2_20726797_ChIP-Seq_SW620_Human1.93279048
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87400149
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87400149
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87400149
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.86500631
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84280111
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81867435
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.81525254
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70298176
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66759921
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.66674668
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62800630
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57197892
33VDR_22108803_ChIP-Seq_LS180_Human1.55631989
34TP53_18474530_ChIP-ChIP_U2OS_Human1.51573834
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51220851
36VDR_24787735_ChIP-Seq_THP-1_Human1.50957999
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.50915968
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48107038
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47967816
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47442921
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46849754
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44118817
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.43286509
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43160798
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42617409
46* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42238214
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41614486
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41097242
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.41096258
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39754175
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.39668491
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38988470
53CLOCK_20551151_ChIP-Seq_293T_Human1.38736928
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38676770
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37796300
56* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34704519
57* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34704519
58BRD4_25478319_ChIP-Seq_HGPS_Human1.34485782
59GATA4_25053715_ChIP-Seq_YYC3_Human1.32997266
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.32270854
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31543630
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28792924
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28332758
64CJUN_26792858_Chip-Seq_BT549_Human1.27857451
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25187291
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.24985388
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23973155
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23136505
69CDX2_22108803_ChIP-Seq_LS180_Human1.21838786
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21378122
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.19813806
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18553462
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18544948
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.17861818
75GBX2_23144817_ChIP-Seq_PC3_Human1.17061491
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16987868
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15850547
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.14902849
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14819615
80GATA6_25053715_ChIP-Seq_YYC3_Human1.13955830
81IGF1R_20145208_ChIP-Seq_DFB_Human1.13440876
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12733495
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.12146427
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10883052
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.10875508
86* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10318550
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09177471
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07653143
89ZNF274_21170338_ChIP-Seq_K562_Hela1.07602341
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07066711
91KLF5_25053715_ChIP-Seq_YYC3_Human1.06562920
92RACK7_27058665_Chip-Seq_MCF-7_Human1.05336305
93TP53_16413492_ChIP-PET_HCT116_Human1.05136823
94RUNX_20019798_ChIP-Seq_JUKART_Human1.04663276
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03219737
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03097460
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.03015717
98* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02853732
99* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02853732
100BCAT_22108803_ChIP-Seq_LS180_Human1.02631512
101LXR_22292898_ChIP-Seq_THP-1_Human1.02435978
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02307238
103CBP_20019798_ChIP-Seq_JUKART_Human1.02307238
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02235657
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.02028552
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01521949
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01233246
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01123754
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00877435
110GATA3_26560356_Chip-Seq_TH2_Human1.00759085
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.00507531
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99407873
113P53_22387025_ChIP-Seq_ESCs_Mouse0.99120156
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.98618036
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.98381420
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98272404
117AHR_22903824_ChIP-Seq_MCF-7_Human0.98217322
118SMAD4_21799915_ChIP-Seq_A2780_Human0.95663079
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95212792
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94821442
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94787219
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94225957
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93953037
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93858989
125TAF15_26573619_Chip-Seq_HEK293_Human0.93681171
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92997140
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.92963787
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.91216280
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90391737
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90068997
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.89850004
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89770699
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87184578
134* TP63_23658742_ChIP-Seq_EP156T_Human0.86823651
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86176547
136SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85802739
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84373267
138* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84351824
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84236993
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82873930
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82789313
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81679131
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.80828615
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80010008
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.79786092
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79358251
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79043235
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78342707
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76450102
150CREB1_26743006_Chip-Seq_LNCaP_Human0.76041275
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.75523494
152ZNF263_19887448_ChIP-Seq_K562_Human0.75065841
153* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74735597
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.74456825
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.73431092
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.73431092
157KDM2B_26808549_Chip-Seq_K562_Human0.73242602
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73191175
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72694998
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72515733
161CTCF_27219007_Chip-Seq_Bcells_Human0.71951594
162KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71949742
163* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71938055
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70670296
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70466588
166ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69427212
167WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67945476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.14134343
2MP0008438_abnormal_cutaneous_collagen3.48857773
3MP0003303_peritoneal_inflammation3.44007238
4MP0002877_abnormal_melanocyte_morpholog3.38005084
5MP0003724_increased_susceptibility_to3.24505337
6MP0002139_abnormal_hepatobiliary_system3.19389268
7MP0005220_abnormal_exocrine_pancreas3.18863824
8MP0010386_abnormal_urinary_bladder3.13819876
9MP0004264_abnormal_extraembryonic_tissu3.08614943
10MP0003183_abnormal_peptide_metabolism3.05510586
11MP0004043_abnormal_pH_regulation3.03743511
12MP0009840_abnormal_foam_cell3.00966358
13MP0001666_abnormal_nutrient_absorption2.85255001
14MP0006082_CNS_inflammation2.84911498
15MP0000013_abnormal_adipose_tissue2.81957751
16MP0005058_abnormal_lysosome_morphology2.77182383
17MP0000462_abnormal_digestive_system2.75635506
18MP0002693_abnormal_pancreas_physiology2.73555740
19MP0009780_abnormal_chondrocyte_physiolo2.64917506
20MP0003436_decreased_susceptibility_to2.58843473
21MP0009785_altered_susceptibility_to2.58477004
22MP0002148_abnormal_hypersensitivity_rea2.45602804
23MP0001944_abnormal_pancreas_morphology2.40756016
24MP0003950_abnormal_plasma_membrane2.19686839
25MP0005083_abnormal_biliary_tract2.19504922
26MP0000613_abnormal_salivary_gland2.10034143
27MP0005379_endocrine/exocrine_gland_phen2.04469609
28MP0009764_decreased_sensitivity_to2.02156149
29MP0005171_absent_coat_pigmentation1.95678426
30MP0005275_abnormal_skin_tensile1.95636420
31MP0005164_abnormal_response_to1.94338533
32MP0000604_amyloidosis1.84690309
33MP0000343_altered_response_to1.84662393
34MP0002909_abnormal_adrenal_gland1.84449061
35MP0004510_myositis1.84386856
36MP0001533_abnormal_skeleton_physiology1.81315022
37MP0003045_fibrosis1.80471762
38MP0002896_abnormal_bone_mineralization1.77992784
39MP0006054_spinal_hemorrhage1.76731838
40MP0003656_abnormal_erythrocyte_physiolo1.75031832
41MP0002009_preneoplasia1.73494392
42MP0005000_abnormal_immune_tolerance1.73023262
43MP0005503_abnormal_tendon_morphology1.71529595
44MP0003300_gastrointestinal_ulcer1.68905797
45MP0002419_abnormal_innate_immunity1.68683100
46MP0000003_abnormal_adipose_tissue1.66799367
47MP0006072_abnormal_retinal_apoptosis1.66548359
48MP0001835_abnormal_antigen_presentation1.64765001
49MP0004233_abnormal_muscle_weight1.64714983
50MP0003959_abnormal_lean_body1.64019538
51MP0005410_abnormal_fertilization1.57639348
52MP0001845_abnormal_inflammatory_respons1.53379099
53MP0001790_abnormal_immune_system1.52858732
54MP0005387_immune_system_phenotype1.52858732
55MP0003075_altered_response_to1.52635379
56MP0003191_abnormal_cellular_cholesterol1.52223820
57MP0003195_calcinosis1.51912019
58MP0008469_abnormal_protein_level1.49087962
59MP0001664_abnormal_digestion1.48051612
60MP0010155_abnormal_intestine_physiology1.46603161
61MP0000678_abnormal_parathyroid_gland1.45996569
62MP0002060_abnormal_skin_morphology1.43302188
63MP0000470_abnormal_stomach_morphology1.40610939
64MP0002295_abnormal_pulmonary_circulatio1.39821936
65MP0000538_abnormal_urinary_bladder1.39119209
66MP0002332_abnormal_exercise_endurance1.37995576
67MP0005645_abnormal_hypothalamus_physiol1.37799808
68MP0003091_abnormal_cell_migration1.35394242
69MP0005025_abnormal_response_to1.34153599
70MP0005310_abnormal_salivary_gland1.33719259
71MP0005166_decreased_susceptibility_to1.31838176
72MP0010234_abnormal_vibrissa_follicle1.28718779
73MP0003448_altered_tumor_morphology1.25161140
74MP0004883_abnormal_blood_vessel1.24442165
75MP0004272_abnormal_basement_membrane1.23996133
76MP0002254_reproductive_system_inflammat1.23994824
77MP0004947_skin_inflammation1.22886204
78MP0002163_abnormal_gland_morphology1.22586619
79MP0001765_abnormal_ion_homeostasis1.21671441
80MP0002723_abnormal_immune_serum1.21024657
81MP0004134_abnormal_chest_morphology1.20675467
82MP0002078_abnormal_glucose_homeostasis1.20453402
83MP0002998_abnormal_bone_remodeling1.18923002
84MP0002452_abnormal_antigen_presenting1.18174060
85MP0005023_abnormal_wound_healing1.15919926
86MP0003279_aneurysm1.15257821
87MP0004019_abnormal_vitamin_homeostasis1.15060794
88MP0001501_abnormal_sleep_pattern1.13709607
89MP0003252_abnormal_bile_duct1.12844862
90MP0000163_abnormal_cartilage_morphology1.09259215
91MP0005508_abnormal_skeleton_morphology1.08235934
92MP0000465_gastrointestinal_hemorrhage1.07891141
93MP0000685_abnormal_immune_system1.07554950
94MP0005167_abnormal_blood-brain_barrier1.07482318
95MP0003705_abnormal_hypodermis_morpholog1.07012441
96MP0003866_abnormal_defecation1.06422409
97MP0001958_emphysema1.05227720
98MP0005360_urolithiasis1.03729835
99MP0005085_abnormal_gallbladder_physiolo1.03244139
100MP0002405_respiratory_system_inflammati1.02946730
101MP0005381_digestive/alimentary_phenotyp1.02886434
102MP0000858_altered_metastatic_potential1.02427907
103MP0003453_abnormal_keratinocyte_physiol1.01624291
104MP0001800_abnormal_humoral_immune1.00921518
105MP0005671_abnormal_response_to1.00246002
106MP0001853_heart_inflammation0.99953048
107MP0002138_abnormal_hepatobiliary_system0.99658680
108MP0002653_abnormal_ependyma_morphology0.99462787
109MP0010030_abnormal_orbit_morphology0.99307925
110MP0000762_abnormal_tongue_morphology0.98545636
111MP0001346_abnormal_lacrimal_gland0.98445169
112MP0005448_abnormal_energy_balance0.95804184
113MP0003868_abnormal_feces_composition0.95743770
114MP0008004_abnormal_stomach_pH0.93800698
115MP0003172_abnormal_lysosome_physiology0.93766496
116MP0005451_abnormal_body_composition0.93615838
117MP0009763_increased_sensitivity_to0.93357673
118MP0005408_hypopigmentation0.92529147
119MP0005257_abnormal_intraocular_pressure0.91666257
120MP0001243_abnormal_dermal_layer0.91532883
121MP0009643_abnormal_urine_homeostasis0.91373309
122MP0005464_abnormal_platelet_physiology0.89628075
123MP0005084_abnormal_gallbladder_morpholo0.87472665
124MP0001764_abnormal_homeostasis0.84924749
125MP0005365_abnormal_bile_salt0.84810331
126MP0005375_adipose_tissue_phenotype0.84612148
127MP0002837_dystrophic_cardiac_calcinosis0.84259719
128MP0001299_abnormal_eye_distance/0.84063673
129MP0000639_abnormal_adrenal_gland0.82475557
130MP0002098_abnormal_vibrissa_morphology0.81790002
131MP0003329_amyloid_beta_deposits0.81432283
132MP0002277_abnormal_respiratory_mucosa0.80549378
133MP0003566_abnormal_cell_adhesion0.79217466
134MP0003795_abnormal_bone_structure0.79181016
135MP0008875_abnormal_xenobiotic_pharmacok0.79167220
136MP0001819_abnormal_immune_cell0.79027789
137MP0003634_abnormal_glial_cell0.78954660
138MP0002006_tumorigenesis0.78570016
139MP0003953_abnormal_hormone_level0.78561340
140MP0002420_abnormal_adaptive_immunity0.78276667
141MP0000249_abnormal_blood_vessel0.78211068
142MP0005376_homeostasis/metabolism_phenot0.76866329
143MP0002115_abnormal_skeleton_extremities0.76730947
144MP0010678_abnormal_skin_adnexa0.76482145
145MP0002168_other_aberrant_phenotype0.75985497
146MP0001756_abnormal_urination0.75632501
147MP0010329_abnormal_lipoprotein_level0.75464302
148MP0001270_distended_abdomen0.74736473
149MP0005636_abnormal_mineral_homeostasis0.74603969
150MP0002108_abnormal_muscle_morphology0.74544399
151MP0004185_abnormal_adipocyte_glucose0.74071852
152MP0005332_abnormal_amino_acid0.73528585
153MP0008260_abnormal_autophagy0.73143656
154MP0001542_abnormal_bone_strength0.73129991
155MP0005595_abnormal_vascular_smooth0.73115214
156MP0003119_abnormal_digestive_system0.72398328
157MP0000537_abnormal_urethra_morphology0.72083950
158MP0002938_white_spotting0.70615818
159MP0002234_abnormal_pharynx_morphology0.69473922
160MP0000579_abnormal_nail_morphology0.69328753
161MP0003890_abnormal_embryonic-extraembry0.68691078
162MP0001986_abnormal_taste_sensitivity0.68352094
163MP0009250_abnormal_appendicular_skeleto0.68193866
164MP0000383_abnormal_hair_follicle0.67544096
165MP0000681_abnormal_thyroid_gland0.67078113
166MP0005390_skeleton_phenotype0.65570310
167MP0001970_abnormal_pain_threshold0.64916637
168MP0010352_gastrointestinal_tract_polyps0.63475182
169MP0005623_abnormal_meninges_morphology0.61906031
170MP0000920_abnormal_myelination0.61714271
171MP0003942_abnormal_urinary_system0.61694477
172MP0002796_impaired_skin_barrier0.59703398

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.82658583
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.82658583
3Abnormality of glycolipid metabolism (HP:0010969)4.82658583
4Dysostosis multiplex (HP:0000943)4.21576442
5Urinary glycosaminoglycan excretion (HP:0003541)4.11140061
6Mucopolysacchariduria (HP:0008155)4.11140061
7Loss of speech (HP:0002371)4.09101148
8Abnormality of mucopolysaccharide metabolism (HP:0011020)3.74962141
9Abnormality of polysaccharide metabolism (HP:0011012)3.74962141
10Abnormality of glycosaminoglycan metabolism (HP:0004371)3.74962141
11Hyperinsulinemic hypoglycemia (HP:0000825)3.66982063
12Stomatitis (HP:0010280)3.56764068
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.48540448
14Large for gestational age (HP:0001520)3.36887615
15Exocrine pancreatic insufficiency (HP:0001738)3.35147165
16Orchitis (HP:0100796)3.25672603
17Abnormality of macrophages (HP:0004311)3.23043783
18Retrobulbar optic neuritis (HP:0100654)3.22531251
19Optic neuritis (HP:0100653)3.22531251
20Hypoglycemic seizures (HP:0002173)3.16929083
21Hyperparathyroidism (HP:0000843)3.16540555
22Symptomatic seizures (HP:0011145)3.12354326
23Vacuolated lymphocytes (HP:0001922)3.06151907
24Systemic lupus erythematosus (HP:0002725)3.05301583
25Hematochezia (HP:0002573)3.04080911
26Abnormality of the pancreatic islet cells (HP:0006476)3.01098935
27Abnormality of endocrine pancreas physiology (HP:0012093)3.01098935
28Thoracolumbar scoliosis (HP:0002944)2.99753859
29Disinhibition (HP:0000734)2.93801555
30Pancreatic islet-cell hyperplasia (HP:0004510)2.92643478
31Fragile skin (HP:0001030)2.92639589
32Fat malabsorption (HP:0002630)2.92609347
33Tetraparesis (HP:0002273)2.92298305
34Steatorrhea (HP:0002570)2.89675042
35Follicular hyperkeratosis (HP:0007502)2.89652503
36Malnutrition (HP:0004395)2.76734634
37Atrophic scars (HP:0001075)2.76433728
38Congenital glaucoma (HP:0001087)2.75430225
39Mitral stenosis (HP:0001718)2.74287812
40Insulin-resistant diabetes mellitus (HP:0000831)2.71495338
41Male infertility (HP:0003251)2.67243950
42Dysautonomia (HP:0002459)2.63877974
43Glomerulonephritis (HP:0000099)2.62412442
44Mutism (HP:0002300)2.61228379
45Alacrima (HP:0000522)2.59799697
46Myositis (HP:0100614)2.59388754
47Joint stiffness (HP:0001387)2.59126837
48Premature rupture of membranes (HP:0001788)2.56090495
49Turricephaly (HP:0000262)2.51623109
50Nuclear cataract (HP:0100018)2.50428951
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50112289
52Abdominal distention (HP:0003270)2.46485040
53Abnormal tarsal ossification (HP:0008369)2.45314307
54Flat acetabular roof (HP:0003180)2.42945261
55Spondylolisthesis (HP:0003302)2.42839724
56Epiphyseal dysplasia (HP:0002656)2.40495291
57Cardiovascular calcification (HP:0011915)2.37990477
58Hypoglycemic coma (HP:0001325)2.33326217
59Amyloidosis (HP:0011034)2.32510323
60Osteomalacia (HP:0002749)2.32285165
61Pulmonary infiltrates (HP:0002113)2.32243312
62Abnormality of calcium-phosphate metabolism (HP:0100530)2.32111498
63Aortic dissection (HP:0002647)2.31262420
64Eczematoid dermatitis (HP:0000976)2.30703802
65Peritonitis (HP:0002586)2.30325147
66Metaphyseal dysplasia (HP:0100255)2.26467481
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.25443692
68Vertebral hypoplasia (HP:0008417)2.25443692
69Hypokalemia (HP:0002900)2.24649483
70Abnormal hemoglobin (HP:0011902)2.23990543
71Ulnar bowing (HP:0003031)2.22044223
72Abnormal pancreas size (HP:0012094)2.21247824
73Intrahepatic cholestasis (HP:0001406)2.20788955
74Hypoplastic ischia (HP:0003175)2.20666066
75Hypoplasia of the odontoid process (HP:0003311)2.19730411
76Disproportionate short-trunk short stature (HP:0003521)2.18830281
77Azoospermia (HP:0000027)2.16660943
78Protuberant abdomen (HP:0001538)2.16195336
79Beaking of vertebral bodies (HP:0004568)2.15998099
80Vascular calcification (HP:0004934)2.15471098
81Popliteal pterygium (HP:0009756)2.15051148
82Conjugated hyperbilirubinemia (HP:0002908)2.14784878
83Papillary thyroid carcinoma (HP:0002895)2.14637571
84Ketoacidosis (HP:0001993)2.14586206
85Chronic bronchitis (HP:0004469)2.12966956
86Diaphragmatic weakness (HP:0009113)2.12603517
87Hypercortisolism (HP:0001578)2.12568817
88Abnormality of the ischium (HP:0003174)2.11303891
89Hyperglycemia (HP:0003074)2.11275659
90Segmental peripheral demyelination/remyelination (HP:0003481)2.09813070
91Abnormality of the intrinsic pathway (HP:0010989)2.09326370
92Cervical subluxation (HP:0003308)2.08855905
93Episodic fever (HP:0001954)2.06745146
94Aplasia of the musculature (HP:0100854)2.06712414
95Decreased circulating renin level (HP:0003351)2.05962041
96Abnormal foot bone ossification (HP:0010675)2.05255589
97Mildly elevated creatine phosphokinase (HP:0008180)2.04113368
98Pancreatitis (HP:0001733)2.03877043
99Recurrent bacterial skin infections (HP:0005406)2.02747668
100Progressive neurologic deterioration (HP:0002344)2.02674444
101Chronic diarrhea (HP:0002028)2.02417287
102Cupped ribs (HP:0000887)2.02076468
103Complement deficiency (HP:0004431)1.99975662
104Prolonged neonatal jaundice (HP:0006579)1.99624829
105Ovoid vertebral bodies (HP:0003300)1.99266817
106Sensorimotor neuropathy (HP:0007141)1.98558135
107Abnormality of dentin (HP:0010299)1.97179865
108Premature skin wrinkling (HP:0100678)1.96143543
109Irregular vertebral endplates (HP:0003301)1.95723976
110Joint swelling (HP:0001386)1.95395287
111Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94214110
112Platyspondyly (HP:0000926)1.93364411
113Increased CSF protein (HP:0002922)1.93297887
114Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91970190
115Keratoconjunctivitis (HP:0001096)1.91297542
116Hypotension (HP:0002615)1.91057097
117Autoimmune thrombocytopenia (HP:0001973)1.90711152
118Keratoconjunctivitis sicca (HP:0001097)1.88250078
119Hyperactive renin-angiotensin system (HP:0000841)1.87704115
120Xanthomatosis (HP:0000991)1.87502371
121Mediastinal lymphadenopathy (HP:0100721)1.87421276
122Polyneuropathy (HP:0001271)1.86580321
123Macroorchidism (HP:0000053)1.86561393
124Recurrent gram-negative bacterial infections (HP:0005420)1.86460796
125Gastrointestinal infarctions (HP:0005244)1.86209904
126Hemoptysis (HP:0002105)1.85937812
127Vascular tortuosity (HP:0004948)1.85912787
128Menstrual irregularities (HP:0000858)1.85847419
129Growth hormone excess (HP:0000845)1.85590081
130Anteriorly placed anus (HP:0001545)1.84933625
131Myocardial infarction (HP:0001658)1.84908617
132Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.84453615
133Retinal atrophy (HP:0001105)1.83083016
134Albinism (HP:0001022)1.82952643
135Pheochromocytoma (HP:0002666)1.81779347
136Recurrent abscess formation (HP:0002722)1.81594020
137Nausea (HP:0002018)1.81536193
138Thin bony cortex (HP:0002753)1.80790231
139Metaphyseal irregularity (HP:0003025)1.80575187
140Ileus (HP:0002595)1.80162161
141Decreased lacrimation (HP:0000633)1.79614918
142Progressive sensorineural hearing impairment (HP:0000408)1.79425896
143Right ventricular cardiomyopathy (HP:0011663)1.79414235
144Abnormality of the odontoid process (HP:0003310)1.79037091
145Neurofibrillary tangles (HP:0002185)1.78272833
146Gangrene (HP:0100758)1.78134279
147Hyperphosphatemia (HP:0002905)1.76822433
148Orthostatic hypotension (HP:0001278)1.76467274
149Coronal craniosynostosis (HP:0004440)1.75417269
150Alopecia of scalp (HP:0002293)1.75222108
151Decreased subcutaneous fat (HP:0001002)1.74846033
152Congenital sensorineural hearing impairment (HP:0008527)1.74266690
153Hypothermia (HP:0002045)1.73154850
154Vertebral compression fractures (HP:0002953)1.73058059
155Abnormality of the basal ganglia (HP:0002134)1.72599177
156Late onset (HP:0003584)1.72505942
157Enlarged epiphyses (HP:0010580)1.72343766
158Parakeratosis (HP:0001036)1.71591290
159Flattened epiphyses (HP:0003071)1.69677674
160Retinal dysplasia (HP:0007973)1.69341009
161Hydroxyprolinuria (HP:0003080)1.68688913
162Abnormality of proline metabolism (HP:0010907)1.68688913
163Nephrogenic diabetes insipidus (HP:0009806)1.67608606
164Abnormality of the vasculature of the conjunctiva (HP:0008054)1.65170154
165Delayed gross motor development (HP:0002194)1.64473205
166Abnormality of the common coagulation pathway (HP:0010990)1.61968897
167Hypokalemic alkalosis (HP:0001949)1.61541222
168Abnormal spermatogenesis (HP:0008669)1.61119312
169Dilatation of the ascending aorta (HP:0005111)1.60364936
170Keratitis (HP:0000491)1.60287410
171Gingival bleeding (HP:0000225)1.59385530
172Vasculitis (HP:0002633)1.58762034
173Elevated erythrocyte sedimentation rate (HP:0003565)1.56861629
174Epidermoid cyst (HP:0200040)1.56308410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.10806198
2DDR23.41091769
3INSRR3.18415144
4MAP4K23.11481218
5ERN12.84682926
6FRK2.76258400
7MAP3K142.73047550
8AKT32.53633251
9TAOK32.24897959
10GRK72.24708526
11ICK2.23319978
12MST42.19440422
13WNK42.15453720
14ACVR1B2.12307114
15MAP2K22.07418306
16STK392.06877253
17PDGFRA2.01187358
18HIPK22.00904851
19PASK1.99798637
20MET1.95459810
21STK241.93952127
22EPHB11.85322208
23TGFBR21.82779899
24TYK21.78392163
25TBK11.76426077
26MAP3K21.74634388
27NTRK11.66129632
28DYRK1B1.65117859
29UHMK11.64950142
30JAK11.64930545
31BMPR21.60354194
32MOS1.59223163
33PIM21.55260895
34MAP3K121.48361251
35IKBKE1.46625144
36EPHA31.43899157
37LATS11.43012503
38NEK91.42435002
39TRPM71.36226849
40IKBKB1.35334634
41LMTK21.34310946
42TRIM281.31666403
43MATK1.30635308
44PRKD31.28582684
45TESK11.27523237
46MAP3K51.24634338
47FER1.21160151
48TRIB31.20755600
49TAOK21.20588927
50MAP3K11.19373307
51SIK31.14908321
52CASK1.10596458
53TXK1.10564473
54BCKDK1.10419089
55FLT31.10067835
56FGR1.08656833
57PRKD21.07449454
58PRKG21.07146233
59PTK21.05400849
60FGFR31.02701692
61GSK3A1.01608597
62PDK21.01210343
63PIK3CG1.00729586
64PDGFRB1.00434169
65MAP3K61.00286906
66BMX1.00123634
67EPHA20.97811753
68CDC42BPA0.95930933
69ZAP700.93469585
70IRAK40.93118084
71BMPR1B0.93028273
72SCYL20.90098183
73BLK0.88343870
74PBK0.87265464
75CSK0.86806316
76PLK20.84937036
77PTK60.84899723
78STK160.84843666
79MAP3K30.83624457
80MAP3K110.83010052
81CAMK2D0.82085311
82RIPK10.81806174
83MAPKAPK30.80373875
84ERBB30.79350363
85PIK3CA0.78825962
86ARAF0.75131532
87CSF1R0.74357605
88PAK20.73018047
89JAK20.71670204
90YES10.71209241
91MAP2K10.69841142
92ABL20.69416891
93MST1R0.68108618
94TYRO30.66534000
95IRAK30.64171915
96PAK30.63441097
97MAPKAPK50.62122102
98CAMK2B0.61013787
99SIK10.60578727
100IRAK10.60300717
101JAK30.58567187
102PRKCE0.58098596
103KSR10.57520616
104CAMKK20.54947005
105PRKD10.54266580
106NUAK10.52893663
107PINK10.51563126
108LYN0.51265271
109PDK30.50187641
110PDK40.50187641
111ABL10.48703663
112EPHB20.47652982
113TAOK10.47018847
114STK100.46099129
115LIMK10.45429237
116CLK10.44403802
117KIT0.44295569
118DYRK20.44197732
119OXSR10.44146027
120MTOR0.44134034
121NLK0.44097554
122RET0.43649503
123STK30.42756961
124RPS6KC10.42591055
125RPS6KL10.42591055
126RPS6KA40.41891470
127WNK10.40602053
128PRKAA10.40583815
129EIF2AK30.39724544
130RPS6KA60.37874753
131CDK60.36391997
132ADRBK10.36070452
133BCR0.35897082
134EGFR0.35538978
135GRK10.34822396
136RPS6KA20.34717502
137* INSR0.34042022
138RPS6KB10.33476715
139MAPKAPK20.33417111
140MAP2K60.33310078
141STK38L0.32724880
142MYLK0.32111833
143PIM10.31204317
144NME10.30735390
145PRKCI0.30728866
146CHUK0.28984707
147IGF1R0.28718228
148MAP3K130.28515723
149ADRBK20.28248085
150CAMK2G0.27648724
151LCK0.26910661
152MAP3K40.24692078
153MAPK70.24393870

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.99327488
2Protein export_Homo sapiens_hsa030605.20601756
3Sulfur metabolism_Homo sapiens_hsa009204.01238666
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.43954036
5Vibrio cholerae infection_Homo sapiens_hsa051102.44561957
6Protein digestion and absorption_Homo sapiens_hsa049742.40092755
7Pancreatic secretion_Homo sapiens_hsa049722.31161172
8Pertussis_Homo sapiens_hsa051332.10964085
9TNF signaling pathway_Homo sapiens_hsa046682.07600055
10Fat digestion and absorption_Homo sapiens_hsa049751.97805672
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86347399
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.85782821
13Malaria_Homo sapiens_hsa051441.83510206
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81045853
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.79828685
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77871350
17Lysosome_Homo sapiens_hsa041421.72781198
18Staphylococcus aureus infection_Homo sapiens_hsa051501.71788798
19N-Glycan biosynthesis_Homo sapiens_hsa005101.67286053
20Osteoclast differentiation_Homo sapiens_hsa043801.67258666
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65993101
22Complement and coagulation cascades_Homo sapiens_hsa046101.64162124
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61044876
24Insulin secretion_Homo sapiens_hsa049111.57087184
25Leishmaniasis_Homo sapiens_hsa051401.53439858
26Graft-versus-host disease_Homo sapiens_hsa053321.48819282
27Mineral absorption_Homo sapiens_hsa049781.48398271
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.47701870
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45041525
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43497455
31Folate biosynthesis_Homo sapiens_hsa007901.38994354
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.38829855
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37743294
34Tuberculosis_Homo sapiens_hsa051521.36764108
35Renin-angiotensin system_Homo sapiens_hsa046141.33079926
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32795920
37Allograft rejection_Homo sapiens_hsa053301.31402586
38Other glycan degradation_Homo sapiens_hsa005111.30284857
39African trypanosomiasis_Homo sapiens_hsa051431.29124292
40Collecting duct acid secretion_Homo sapiens_hsa049661.28611261
41Steroid biosynthesis_Homo sapiens_hsa001001.25813259
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25726542
43Asthma_Homo sapiens_hsa053101.25661551
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22827093
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.20794554
46Fatty acid biosynthesis_Homo sapiens_hsa000611.16629520
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14165424
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11941223
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11363117
50Toxoplasmosis_Homo sapiens_hsa051451.09633999
51Shigellosis_Homo sapiens_hsa051311.07170836
52Influenza A_Homo sapiens_hsa051641.06334148
53Linoleic acid metabolism_Homo sapiens_hsa005911.05220042
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.05170500
55Phagosome_Homo sapiens_hsa041451.04252468
56Hematopoietic cell lineage_Homo sapiens_hsa046401.02892909
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00902624
58Sphingolipid metabolism_Homo sapiens_hsa006000.99718777
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99631663
60Type II diabetes mellitus_Homo sapiens_hsa049300.96950614
61Cocaine addiction_Homo sapiens_hsa050300.95806472
62ECM-receptor interaction_Homo sapiens_hsa045120.93936669
63Bladder cancer_Homo sapiens_hsa052190.93870376
64Arginine and proline metabolism_Homo sapiens_hsa003300.92269262
65Galactose metabolism_Homo sapiens_hsa000520.91256899
66Measles_Homo sapiens_hsa051620.89101688
67Autoimmune thyroid disease_Homo sapiens_hsa053200.88454296
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83898453
69Circadian rhythm_Homo sapiens_hsa047100.83567038
70Thyroid hormone synthesis_Homo sapiens_hsa049180.81345394
71Tryptophan metabolism_Homo sapiens_hsa003800.81046416
72Hepatitis C_Homo sapiens_hsa051600.79747965
73PPAR signaling pathway_Homo sapiens_hsa033200.79186011
74Fructose and mannose metabolism_Homo sapiens_hsa000510.78681910
75Type I diabetes mellitus_Homo sapiens_hsa049400.77824828
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76680278
77Chemokine signaling pathway_Homo sapiens_hsa040620.75067286
78Rheumatoid arthritis_Homo sapiens_hsa053230.74542165
79Legionellosis_Homo sapiens_hsa051340.74398600
80Caffeine metabolism_Homo sapiens_hsa002320.72601026
81Dorso-ventral axis formation_Homo sapiens_hsa043200.71247945
82Histidine metabolism_Homo sapiens_hsa003400.69629850
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69126155
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.68750357
85Ether lipid metabolism_Homo sapiens_hsa005650.68738376
86Chemical carcinogenesis_Homo sapiens_hsa052040.67684298
87Selenocompound metabolism_Homo sapiens_hsa004500.67055095
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67042712
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65792055
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64578160
91Hepatitis B_Homo sapiens_hsa051610.63984188
92Arachidonic acid metabolism_Homo sapiens_hsa005900.63440423
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62404059
94Herpes simplex infection_Homo sapiens_hsa051680.62396006
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62278612
96Focal adhesion_Homo sapiens_hsa045100.61948339
97Tight junction_Homo sapiens_hsa045300.60475275
98Peroxisome_Homo sapiens_hsa041460.58117552
99Prolactin signaling pathway_Homo sapiens_hsa049170.56785389
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56637152
101Adherens junction_Homo sapiens_hsa045200.56388525
102Oxidative phosphorylation_Homo sapiens_hsa001900.54940010
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.54870517
104ABC transporters_Homo sapiens_hsa020100.54492952
105Prostate cancer_Homo sapiens_hsa052150.54211262
106Vitamin digestion and absorption_Homo sapiens_hsa049770.53986876
107Glutathione metabolism_Homo sapiens_hsa004800.52439615
108Starch and sucrose metabolism_Homo sapiens_hsa005000.52202678
109Hedgehog signaling pathway_Homo sapiens_hsa043400.50963620
110mTOR signaling pathway_Homo sapiens_hsa041500.50673770
111Amoebiasis_Homo sapiens_hsa051460.50165625
112Antigen processing and presentation_Homo sapiens_hsa046120.50021991
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49656546
114Sulfur relay system_Homo sapiens_hsa041220.48503488
115Glycerolipid metabolism_Homo sapiens_hsa005610.48179120
116Regulation of autophagy_Homo sapiens_hsa041400.47480073
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46347035
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46011945
119Hippo signaling pathway_Homo sapiens_hsa043900.45945089
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45847730
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.43108838
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43062370
123Taste transduction_Homo sapiens_hsa047420.42903668
124Estrogen signaling pathway_Homo sapiens_hsa049150.40699462
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.39366000
126Fatty acid degradation_Homo sapiens_hsa000710.39343123
127Viral myocarditis_Homo sapiens_hsa054160.39154933
128Insulin resistance_Homo sapiens_hsa049310.38775096
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38747851
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38426571
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38324174
132Prion diseases_Homo sapiens_hsa050200.37823873
133TGF-beta signaling pathway_Homo sapiens_hsa043500.37578542
134Apoptosis_Homo sapiens_hsa042100.36622357
135Synaptic vesicle cycle_Homo sapiens_hsa047210.35300442
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34451002
137T cell receptor signaling pathway_Homo sapiens_hsa046600.32141428
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31110082
139Amphetamine addiction_Homo sapiens_hsa050310.30807716
140Alzheimers disease_Homo sapiens_hsa050100.30171317
141* Endocytosis_Homo sapiens_hsa041440.29721018
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29597997
143Notch signaling pathway_Homo sapiens_hsa043300.27753103
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27241506
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27006229
146Salmonella infection_Homo sapiens_hsa051320.26921026
147Proteoglycans in cancer_Homo sapiens_hsa052050.26849731
148AMPK signaling pathway_Homo sapiens_hsa041520.23942757
149Fatty acid elongation_Homo sapiens_hsa000620.22150147
150ErbB signaling pathway_Homo sapiens_hsa040120.20273955
151VEGF signaling pathway_Homo sapiens_hsa043700.18499784
152Wnt signaling pathway_Homo sapiens_hsa043100.17012427
153Renin secretion_Homo sapiens_hsa049240.16958433

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