ARFGEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.84624245
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.18719632
3pre-miRNA processing (GO:0031054)4.88040812
4pore complex assembly (GO:0046931)4.45916882
5protein targeting to Golgi (GO:0000042)4.44546780
6cytoplasmic mRNA processing body assembly (GO:0033962)4.35628904
7interkinetic nuclear migration (GO:0022027)4.33939481
8establishment of protein localization to Golgi (GO:0072600)4.16897516
9regulation of posttranscriptional gene silencing (GO:0060147)4.11772079
10regulation of gene silencing by miRNA (GO:0060964)4.11772079
11regulation of gene silencing by RNA (GO:0060966)4.11772079
12retrograde transport, vesicle recycling within Golgi (GO:0000301)4.07107482
13negative regulation of DNA repair (GO:0045738)3.95996184
14regulation of histone H3-K9 methylation (GO:0051570)3.94644280
15growth hormone receptor signaling pathway (GO:0060396)3.83188598
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.77502697
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.77502697
18regulation of translation, ncRNA-mediated (GO:0045974)3.77502697
19positive regulation of catenin import into nucleus (GO:0035413)3.49454475
20regulation of chromatin silencing (GO:0031935)3.37964531
21protein localization to endosome (GO:0036010)3.36762281
22histone demethylation (GO:0016577)3.26670512
23cellular response to growth hormone stimulus (GO:0071378)3.25847531
24determination of adult lifespan (GO:0008340)3.21829508
25negative regulation of fibroblast apoptotic process (GO:2000270)3.18410706
26sister chromatid cohesion (GO:0007062)3.17596362
27bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16693383
28macroautophagy (GO:0016236)3.15655191
29regulation of clathrin-mediated endocytosis (GO:2000369)3.12290352
30negative regulation of histone methylation (GO:0031061)3.10022846
31embryonic process involved in female pregnancy (GO:0060136)3.05868445
32nucleus localization (GO:0051647)3.05865495
33histone H3-K4 trimethylation (GO:0080182)3.03325764
34histone mRNA catabolic process (GO:0071044)3.02722723
35protein K48-linked deubiquitination (GO:0071108)3.01341344
36regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01132670
37peptidyl-lysine trimethylation (GO:0018023)2.99373187
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.99252713
39regulation of gene silencing (GO:0060968)2.98887328
40regulation of histone H3-K27 methylation (GO:0061085)2.97761785
41regulation of centriole replication (GO:0046599)2.93079016
42positive regulation of SMAD protein import into nucleus (GO:0060391)2.91723869
43regulation of fibroblast apoptotic process (GO:2000269)2.89301127
44positive regulation of histone deacetylation (GO:0031065)2.89202984
45nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.88932801
46phospholipid translocation (GO:0045332)2.88217991
47lipid translocation (GO:0034204)2.88217991
48Golgi transport vesicle coating (GO:0048200)2.85201215
49COPI coating of Golgi vesicle (GO:0048205)2.85201215
50histone H3-K9 demethylation (GO:0033169)2.84652323
51regulation of meiosis I (GO:0060631)2.83233145
52intestinal absorption (GO:0050892)2.79511874
53gene silencing by RNA (GO:0031047)2.78699697
54iron ion import (GO:0097286)2.76855476
55corticosteroid receptor signaling pathway (GO:0031958)2.74753289
56cellular response to ethanol (GO:0071361)2.74404541
57protein dealkylation (GO:0008214)2.72913902
58protein demethylation (GO:0006482)2.72913902
59nerve growth factor signaling pathway (GO:0038180)2.72840115
60regulation of cholesterol homeostasis (GO:2000188)2.70085668
61regulation of DNA endoreduplication (GO:0032875)2.68576614
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.66176036
63oocyte development (GO:0048599)2.65804419
64histone H3-K4 methylation (GO:0051568)2.64800802
65desmosome organization (GO:0002934)2.64191616
66histone H3-K36 demethylation (GO:0070544)2.63270340
67COPII vesicle coating (GO:0048208)2.63148186
68paraxial mesoderm development (GO:0048339)2.58858761
69genitalia morphogenesis (GO:0035112)2.56148835
70endoplasmic reticulum organization (GO:0007029)2.55169714
71positive regulation of protein import into nucleus, translocation (GO:0033160)2.50524971
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50423680
73negative regulation of cell killing (GO:0031342)2.50423680
74glomerular visceral epithelial cell development (GO:0072015)2.49930638
75regulation of transforming growth factor beta2 production (GO:0032909)2.49689933
76mitotic sister chromatid cohesion (GO:0007064)2.48264955
77negative regulation of keratinocyte proliferation (GO:0010839)2.46686107
78positive regulation of glycolytic process (GO:0045821)2.46269411
79histone H3-K9 methylation (GO:0051567)2.46022073
80N-terminal protein amino acid acetylation (GO:0006474)2.43505158
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43452915
82labyrinthine layer development (GO:0060711)2.43422174
83* regulation of establishment of cell polarity (GO:2000114)2.43123040
84regulation of Rac protein signal transduction (GO:0035020)2.42917260
85regulation of histone methylation (GO:0031060)2.41979197
86protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.40911543
87nucleus organization (GO:0006997)2.39604737
88regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39389698
89peptidyl-lysine methylation (GO:0018022)2.39233600
90glucocorticoid receptor signaling pathway (GO:0042921)2.38548445
91phospholipid homeostasis (GO:0055091)2.38006668
92regulation of hippo signaling (GO:0035330)2.36632258
93activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36222681
94intestinal cholesterol absorption (GO:0030299)2.35745523
95protein K11-linked deubiquitination (GO:0035871)2.35678457
96DNA geometric change (GO:0032392)2.35310363
97negative regulation of hormone metabolic process (GO:0032351)2.35280845
98negative regulation of hormone biosynthetic process (GO:0032353)2.35280845
99positive regulation of macroautophagy (GO:0016239)2.35280070
100intracellular lipid transport (GO:0032365)2.35200132
101regulation of gamma-delta T cell differentiation (GO:0045586)2.34363846
102centrosome localization (GO:0051642)2.33822840
103DNA duplex unwinding (GO:0032508)2.33553766
104UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32656871
105peptidyl-threonine modification (GO:0018210)2.31770030
106sequestering of metal ion (GO:0051238)2.31591407
107histone lysine methylation (GO:0034968)2.30543094
108positive regulation of DNA-templated transcription, initiation (GO:2000144)2.30399210
109protein localization to Golgi apparatus (GO:0034067)2.28415031
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.27939863
111monoubiquitinated protein deubiquitination (GO:0035520)2.27217689
112positive regulation of hormone biosynthetic process (GO:0046886)2.26372212
113drug transmembrane transport (GO:0006855)2.25339391
114phospholipid dephosphorylation (GO:0046839)2.24370190
115vesicle coating (GO:0006901)2.23646476
116phosphatidylinositol dephosphorylation (GO:0046856)2.22471429
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.22405880
118peptidyl-threonine phosphorylation (GO:0018107)2.21928951
119ER overload response (GO:0006983)2.21753341
120regulation of protein polyubiquitination (GO:1902914)2.21710244
121hepatocyte apoptotic process (GO:0097284)2.21592699
122positive regulation of nuclease activity (GO:0032075)2.18728225
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.17450365
124early endosome to late endosome transport (GO:0045022)2.16929059
125regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.16783903
126relaxation of cardiac muscle (GO:0055119)2.16517668
127intestinal epithelial cell development (GO:0060576)2.16003629
128type B pancreatic cell development (GO:0003323)2.12227391
129Golgi to endosome transport (GO:0006895)2.11357244
130regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.10094008
131positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.10094008
132hypotonic response (GO:0006971)2.09370673
133NLS-bearing protein import into nucleus (GO:0006607)2.09244989
134positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.08070866
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.08070866
136phosphatidylinositol phosphorylation (GO:0046854)2.07610396
137histone lysine demethylation (GO:0070076)2.06764119
138dicarboxylic acid biosynthetic process (GO:0043650)2.04484961
139* Golgi organization (GO:0007030)2.03762878
140drug catabolic process (GO:0042737)2.03601499
141stress granule assembly (GO:0034063)2.03240763
142intra-Golgi vesicle-mediated transport (GO:0006891)2.01711184
143endoplasmic reticulum unfolded protein response (GO:0030968)2.01296737
144regulation of nucleobase-containing compound transport (GO:0032239)2.01141726
145regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.00476600
146ER-nucleus signaling pathway (GO:0006984)2.00384370
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.99317432
148regulation of membrane protein ectodomain proteolysis (GO:0051043)1.99099798
149urea metabolic process (GO:0019627)1.98822613
150urea cycle (GO:0000050)1.98822613
151cytoskeletal anchoring at plasma membrane (GO:0007016)1.98742688
152regulation of hormone biosynthetic process (GO:0046885)1.97994559
153regulation of RNA export from nucleus (GO:0046831)1.97399663
154regulation of nuclease activity (GO:0032069)1.96603114
155regulation of bile acid biosynthetic process (GO:0070857)1.95703135
156regulation of mRNA catabolic process (GO:0061013)1.94476268
157response to growth hormone (GO:0060416)1.94384244
158antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.92998102
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.92998102
160cysteine metabolic process (GO:0006534)1.92648747
161cellular response to unfolded protein (GO:0034620)1.92623178
162negative regulation of lipid transport (GO:0032369)1.92324044
163nuclear pore complex assembly (GO:0051292)1.91969451
164coronary vasculature morphogenesis (GO:0060977)1.91463171
165inner ear receptor cell development (GO:0060119)1.91439614
166transcytosis (GO:0045056)1.91141795
167bile acid and bile salt transport (GO:0015721)1.90559599
168endocrine pancreas development (GO:0031018)1.90205106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human2.88003536
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48844218
3KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29046519
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20038051
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08307518
6ZNF217_24962896_ChIP-Seq_MCF-7_Human2.07327110
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05274778
8GATA1_22025678_ChIP-Seq_K562_Human2.03811230
9LXR_22158963_ChIP-Seq_LIVER_Mouse1.95042952
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94809907
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92876371
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84501230
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.82981151
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74197336
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73519141
16RXR_22158963_ChIP-Seq_LIVER_Mouse1.72601119
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66285066
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65964421
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65378136
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.64453737
21* FLI1_27457419_Chip-Seq_LIVER_Mouse1.63771335
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.63633153
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57837010
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53260091
25* ESR1_20079471_ChIP-ChIP_T-47D_Human1.49961857
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47224953
27TP53_16413492_ChIP-PET_HCT116_Human1.45783082
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40350340
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40350340
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40350340
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40249767
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39661520
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38762685
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.38751804
35FUS_26573619_Chip-Seq_HEK293_Human1.38501045
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38487352
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36806238
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35591225
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35172425
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.34247247
41AHR_22903824_ChIP-Seq_MCF-7_Human1.33120192
42ER_23166858_ChIP-Seq_MCF-7_Human1.32193661
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.31882514
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30475595
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.30454443
46* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29766922
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28889978
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28449309
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.28313571
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26646427
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25986080
52AR_21572438_ChIP-Seq_LNCaP_Human1.25950562
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.25755684
54STAT3_23295773_ChIP-Seq_U87_Human1.25022469
55* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23249025
56* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23049648
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22659781
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22400195
59P300_19829295_ChIP-Seq_ESCs_Human1.22217703
60SMAD4_21799915_ChIP-Seq_A2780_Human1.20978451
61* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20542438
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19441866
63BRD4_25478319_ChIP-Seq_HGPS_Human1.19143655
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18748658
65* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18711156
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18167596
67BCAT_22108803_ChIP-Seq_LS180_Human1.18078007
68* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16685629
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16555796
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15831095
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.15227104
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15209983
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.14505248
74EWS_26573619_Chip-Seq_HEK293_Human1.14283305
75* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12927723
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12507678
77* TP63_23658742_ChIP-Seq_EP156T_Human1.12013840
78RUNX_20019798_ChIP-Seq_JUKART_Human1.11991699
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11448593
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11040266
81RXR_22108803_ChIP-Seq_LS180_Human1.10129708
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09998185
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09860195
84IGF1R_20145208_ChIP-Seq_DFB_Human1.09811404
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09690843
86* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08889406
87* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07560413
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07203903
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06556874
90FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05571438
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05491478
92* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04739897
93* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04661753
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04656662
95GATA6_25053715_ChIP-Seq_YYC3_Human1.04203218
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03684544
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03684544
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.03571574
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02986871
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02986871
101TCF4_23295773_ChIP-Seq_U87_Human1.02677680
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02649978
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02649978
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02217674
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.02191580
106CDX2_22108803_ChIP-Seq_LS180_Human1.02137340
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02096406
108* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01996689
109* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00980892
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00933464
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.00476234
112DROSHA_22980978_ChIP-Seq_HELA_Human1.00045848
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00002808
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.99281032
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99058173
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98708954
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97208643
118TAF15_26573619_Chip-Seq_HEK293_Human0.96257590
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96051747
120AR_19668381_ChIP-Seq_PC3_Human0.95942989
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95234354
122VDR_24787735_ChIP-Seq_THP-1_Human0.95080999
123CJUN_26792858_Chip-Seq_BT549_Human0.94822709
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94796612
125CLOCK_20551151_ChIP-Seq_293T_Human0.93141705
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92588765
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92335480
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.91587992
129GATA4_25053715_ChIP-Seq_YYC3_Human0.91554329
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90980376
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.90794289
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.90348374
133GBX2_23144817_ChIP-Seq_PC3_Human0.90310682
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.90271706
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90093741
136PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89933746
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88175107
138KDM2B_26808549_Chip-Seq_K562_Human0.87717177
139* SOX2_20726797_ChIP-Seq_SW620_Human0.87483011
140AR_25329375_ChIP-Seq_VCAP_Human0.86985573
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86592576
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86592144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.96456643
2MP0008057_abnormal_DNA_replication5.36631868
3MP0003300_gastrointestinal_ulcer4.03591591
4MP0002877_abnormal_melanocyte_morpholog3.21760993
5MP0005360_urolithiasis3.16770116
6MP0002139_abnormal_hepatobiliary_system3.14773212
7MP0003252_abnormal_bile_duct3.05299171
8MP0005365_abnormal_bile_salt2.93909526
9MP0009780_abnormal_chondrocyte_physiolo2.85503109
10MP0010352_gastrointestinal_tract_polyps2.75411051
11MP0008877_abnormal_DNA_methylation2.69243307
12MP0004264_abnormal_extraembryonic_tissu2.68225868
13MP0003941_abnormal_skin_development2.62152593
14MP0000569_abnormal_digit_pigmentation2.61714255
15MP0005085_abnormal_gallbladder_physiolo2.55249997
16MP0002796_impaired_skin_barrier2.33907873
17MP0001666_abnormal_nutrient_absorption2.20698617
18MP0003868_abnormal_feces_composition2.18922857
19MP0008961_abnormal_basal_metabolism2.17543155
20MP0002166_altered_tumor_susceptibility2.10653012
21MP0003303_peritoneal_inflammation2.09044957
22MP0003045_fibrosis2.07551203
23MP0005076_abnormal_cell_differentiation2.03625702
24MP0003183_abnormal_peptide_metabolism2.01739590
25MP0010678_abnormal_skin_adnexa1.97314892
26MP0005187_abnormal_penis_morphology1.90040644
27MP0003705_abnormal_hypodermis_morpholog1.86576465
28MP0002909_abnormal_adrenal_gland1.82418606
29MP0004185_abnormal_adipocyte_glucose1.79879343
30MP0004957_abnormal_blastocyst_morpholog1.79136382
31MP0005310_abnormal_salivary_gland1.78976878
32MP0002928_abnormal_bile_duct1.78192496
33MP0002396_abnormal_hematopoietic_system1.76285452
34MP0008875_abnormal_xenobiotic_pharmacok1.68632384
35MP0002138_abnormal_hepatobiliary_system1.56208847
36MP0002693_abnormal_pancreas_physiology1.55698182
37MP0004043_abnormal_pH_regulation1.54389678
38MP0003763_abnormal_thymus_physiology1.51892330
39MP0004130_abnormal_muscle_cell1.46230721
40MP0003950_abnormal_plasma_membrane1.43604237
41MP0002006_tumorigenesis1.42273001
42MP0003984_embryonic_growth_retardation1.39426802
43MP0002088_abnormal_embryonic_growth/wei1.38929972
44MP0005409_darkened_coat_color1.38925450
45MP0002837_dystrophic_cardiac_calcinosis1.38768280
46MP0001944_abnormal_pancreas_morphology1.38719982
47MP0009703_decreased_birth_body1.37343753
48MP0001765_abnormal_ion_homeostasis1.36486653
49MP0005174_abnormal_tail_pigmentation1.34459295
50MP0010329_abnormal_lipoprotein_level1.33941203
51MP0002086_abnormal_extraembryonic_tissu1.33674813
52MP0000377_abnormal_hair_follicle1.32163756
53MP0002009_preneoplasia1.31784411
54MP0009672_abnormal_birth_weight1.31522430
55MP0005248_abnormal_Harderian_gland1.31237603
56MP0001672_abnormal_embryogenesis/_devel1.27746902
57MP0005380_embryogenesis_phenotype1.27746902
58MP0006054_spinal_hemorrhage1.22888736
59MP0005220_abnormal_exocrine_pancreas1.21473353
60MP0000609_abnormal_liver_physiology1.20696123
61MP0004808_abnormal_hematopoietic_stem1.20174718
62MP0002078_abnormal_glucose_homeostasis1.17564208
63MP0004197_abnormal_fetal_growth/weight/1.16615097
64MP0003828_pulmonary_edema1.14890623
65MP0001730_embryonic_growth_arrest1.13359650
66MP0004947_skin_inflammation1.11594784
67MP0004233_abnormal_muscle_weight1.11469764
68MP0003195_calcinosis1.09974156
69MP0010307_abnormal_tumor_latency1.07453862
70MP0005075_abnormal_melanosome_morpholog1.06440837
71MP0002084_abnormal_developmental_patter1.06109102
72MP0004510_myositis1.05206128
73MP0000427_abnormal_hair_cycle1.03095726
74MP0003787_abnormal_imprinting1.02869187
75MP0002118_abnormal_lipid_homeostasis1.02433016
76MP0005666_abnormal_adipose_tissue1.02249391
77MP0005501_abnormal_skin_physiology0.99319099
78MP0003890_abnormal_embryonic-extraembry0.96408398
79MP0003077_abnormal_cell_cycle0.96051787
80MP0003191_abnormal_cellular_cholesterol0.95023053
81MP0003866_abnormal_defecation0.94578820
82MP0000428_abnormal_craniofacial_morphol0.94007455
83MP0000647_abnormal_sebaceous_gland0.93522453
84MP0010094_abnormal_chromosome_stability0.92485374
85MP0010386_abnormal_urinary_bladder0.90993036
86MP0004381_abnormal_hair_follicle0.89690410
87MP0002060_abnormal_skin_morphology0.89602747
88MP0005621_abnormal_cell_physiology0.89583324
89MP0001915_intracranial_hemorrhage0.89176487
90MP0003221_abnormal_cardiomyocyte_apopto0.88684830
91MP0002896_abnormal_bone_mineralization0.88416219
92MP0001697_abnormal_embryo_size0.87750588
93MP0001851_eye_inflammation0.86425232
94MP0000350_abnormal_cell_proliferation0.85933645
95MP0002168_other_aberrant_phenotype0.85446455
96MP0002085_abnormal_embryonic_tissue0.82101107
97MP0002925_abnormal_cardiovascular_devel0.81763749
98MP0000371_diluted_coat_color0.81602257
99MP0003943_abnormal_hepatobiliary_system0.81419303
100MP0005375_adipose_tissue_phenotype0.80394407
101MP0003566_abnormal_cell_adhesion0.80333690
102MP0009643_abnormal_urine_homeostasis0.80303552
103MP0003937_abnormal_limbs/digits/tail_de0.80195394
104MP0001881_abnormal_mammary_gland0.79910453
105MP0001191_abnormal_skin_condition0.79767953
106MP0000003_abnormal_adipose_tissue0.79677523
107MP0001873_stomach_inflammation0.79207511
108MP0000383_abnormal_hair_follicle0.78851159
109MP0005334_abnormal_fat_pad0.78764036
110MP0000432_abnormal_head_morphology0.78412786
111MP0000604_amyloidosis0.78360693
112MP0000537_abnormal_urethra_morphology0.77630017
113MP0002254_reproductive_system_inflammat0.77471314
114MP0002234_abnormal_pharynx_morphology0.77452352
115MP0003111_abnormal_nucleus_morphology0.76605837
116MP0002971_abnormal_brown_adipose0.75859770
117MP0005535_abnormal_body_temperature0.75552198
118MP0000538_abnormal_urinary_bladder0.75031851
119MP0003091_abnormal_cell_migration0.74803814
120MP0001784_abnormal_fluid_regulation0.73687890
121MP0002080_prenatal_lethality0.73529236
122MP0001177_atelectasis0.73352288
123MP0004883_abnormal_blood_vessel0.72654224
124MP0000015_abnormal_ear_pigmentation0.72420948
125MP0002098_abnormal_vibrissa_morphology0.71756067
126MP0003936_abnormal_reproductive_system0.69646084
127MP0005395_other_phenotype0.69635266
128MP0003453_abnormal_keratinocyte_physiol0.69615638
129MP0005451_abnormal_body_composition0.69156048
130MP0003121_genomic_imprinting0.69146236
131MP0004782_abnormal_surfactant_physiolog0.68992004
132MP0003693_abnormal_embryo_hatching0.67971803
133MP0005083_abnormal_biliary_tract0.67654785
134MP0003656_abnormal_erythrocyte_physiolo0.66999585
135MP0001299_abnormal_eye_distance/0.66996142
136MP0010368_abnormal_lymphatic_system0.66490721
137MP0004270_analgesia0.66299570
138MP0010155_abnormal_intestine_physiology0.65963763
139MP0000703_abnormal_thymus_morphology0.65426925
140MP0005384_cellular_phenotype0.65065666
141MP0001919_abnormal_reproductive_system0.64273175
142MP0000470_abnormal_stomach_morphology0.64269337
143MP0010630_abnormal_cardiac_muscle0.63653609
144MP0001756_abnormal_urination0.62984608
145MP0004036_abnormal_muscle_relaxation0.61542970
146MP0005166_decreased_susceptibility_to0.61424155
147MP0005647_abnormal_sex_gland0.61146027
148MP0001661_extended_life_span0.60188450
149MP0000462_abnormal_digestive_system0.59272874
150MP0001790_abnormal_immune_system0.57344254
151MP0005387_immune_system_phenotype0.57344254
152MP0005448_abnormal_energy_balance0.55976531
153MP0005367_renal/urinary_system_phenotyp0.55948503
154MP0000516_abnormal_urinary_system0.55948503
155MP0001879_abnormal_lymphatic_vessel0.55529160
156MP0004087_abnormal_muscle_fiber0.55524882
157MP0005464_abnormal_platelet_physiology0.55420235
158MP0001216_abnormal_epidermal_layer0.54946373
159MP0000613_abnormal_salivary_gland0.54866648
160MP0002136_abnormal_kidney_physiology0.53481478
161MP0005408_hypopigmentation0.52391828
162MP0000627_abnormal_mammary_gland0.52028436
163MP0005551_abnormal_eye_electrophysiolog0.51530947

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.85371249
2Abnormality of the fingertips (HP:0001211)3.63223976
3Subacute progressive viral hepatitis (HP:0006572)3.59852267
4Curly hair (HP:0002212)3.25701413
5Papillary thyroid carcinoma (HP:0002895)3.09839278
6Neonatal hypoglycemia (HP:0001998)3.07511485
7Hematochezia (HP:0002573)3.05423772
8Rhabdomyosarcoma (HP:0002859)2.86262583
9T lymphocytopenia (HP:0005403)2.83636036
10Hyperglycemia (HP:0003074)2.78013768
11Volvulus (HP:0002580)2.70783434
12Flat acetabular roof (HP:0003180)2.65419745
13Intrahepatic cholestasis (HP:0001406)2.64185627
14Nephroblastoma (Wilms tumor) (HP:0002667)2.63966649
15Abnormality of the common coagulation pathway (HP:0010990)2.59600475
16Myocardial infarction (HP:0001658)2.48482282
17Malignant gastrointestinal tract tumors (HP:0006749)2.47729110
18Gastrointestinal carcinoma (HP:0002672)2.47729110
19Abnormality of T cell number (HP:0011839)2.47515748
20Embryonal renal neoplasm (HP:0011794)2.46370816
21Enlarged penis (HP:0000040)2.45729487
22Epidermoid cyst (HP:0200040)2.44549339
23Deep philtrum (HP:0002002)2.42192152
24Medulloblastoma (HP:0002885)2.35492179
25Acanthocytosis (HP:0001927)2.35447029
26Hyperkalemia (HP:0002153)2.35078032
27Rectal prolapse (HP:0002035)2.34131679
28Thyroid carcinoma (HP:0002890)2.33357063
29Central scotoma (HP:0000603)2.33283749
30Hyperinsulinemic hypoglycemia (HP:0000825)2.30773695
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.30366720
32Papilledema (HP:0001085)2.30363274
33Hypoplastic labia majora (HP:0000059)2.30005374
34Pigmentary retinal degeneration (HP:0001146)2.29709616
35Abnormality of the nasal septum (HP:0000419)2.28868218
36Protruding tongue (HP:0010808)2.28449193
37Germ cell neoplasia (HP:0100728)2.23979719
38Hepatoblastoma (HP:0002884)2.22490151
39Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.21041963
40Deep venous thrombosis (HP:0002625)2.18902496
41Overgrowth (HP:0001548)2.17950218
42Insidious onset (HP:0003587)2.16569864
43Termporal pattern (HP:0011008)2.16569864
44Hypoglycemic coma (HP:0001325)2.15393107
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14158896
46Dysmetric saccades (HP:0000641)2.13609446
47Insulin-resistant diabetes mellitus (HP:0000831)2.12125102
48Lip pit (HP:0100267)2.11211263
49Viral hepatitis (HP:0006562)2.10194561
50Hypoglycemic seizures (HP:0002173)2.10063781
51Neoplasm of striated muscle (HP:0009728)2.09444675
52Heterotopia (HP:0002282)2.08682937
53Right ventricular cardiomyopathy (HP:0011663)2.08019664
54Low anterior hairline (HP:0000294)2.07704244
55Sandal gap (HP:0001852)2.07611161
56Transitional cell carcinoma of the bladder (HP:0006740)2.06805289
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05546663
58Conjugated hyperbilirubinemia (HP:0002908)2.05398071
59Thickened calvaria (HP:0002684)2.04969578
60Fair hair (HP:0002286)2.04825061
61Abnormal pancreas size (HP:0012094)2.04769991
62Abnormality of the labia majora (HP:0012881)2.04174036
63Micronodular cirrhosis (HP:0001413)2.03478701
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.03428707
65Neoplasm of the small intestine (HP:0100833)2.02730607
66Arterial thrombosis (HP:0004420)2.01527045
67Chromsome breakage (HP:0040012)2.00828789
68Subaortic stenosis (HP:0001682)2.00017653
69Abnormality of the left ventricular outflow tract (HP:0011103)2.00017653
70Aneurysm (HP:0002617)1.98679386
71Abnormality of chloride homeostasis (HP:0011422)1.97873297
72Esophageal varix (HP:0002040)1.97584944
73Depressed nasal tip (HP:0000437)1.97274792
74Neoplasm of the adrenal cortex (HP:0100641)1.95722729
75Bladder neoplasm (HP:0009725)1.95588914
76Bladder carcinoma (HP:0002862)1.95588914
77Prominent nose (HP:0000448)1.95483375
78Breast carcinoma (HP:0003002)1.94830377
79Autoimmune thrombocytopenia (HP:0001973)1.92401531
80Basal cell carcinoma (HP:0002671)1.91226715
81Ketoacidosis (HP:0001993)1.90466883
82Glioma (HP:0009733)1.90443638
83Abnormality of the intrinsic pathway (HP:0010989)1.90278519
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89757453
85Ependymoma (HP:0002888)1.88516887
86Sensorimotor neuropathy (HP:0007141)1.88125888
87Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87861425
88Hypochromic microcytic anemia (HP:0004840)1.87533887
89Vertebral arch anomaly (HP:0008438)1.86539057
90Biliary tract neoplasm (HP:0100574)1.85230627
91Periodontitis (HP:0000704)1.83940983
92Sparse lateral eyebrow (HP:0005338)1.83509397
93Hyporeflexia of lower limbs (HP:0002600)1.83145535
94Cystic hygroma (HP:0000476)1.82784100
95Abnormality of the frontal sinuses (HP:0002687)1.82445388
96Abnormality of the astrocytes (HP:0100707)1.80052279
97Astrocytoma (HP:0009592)1.80052279
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79744479
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.79327702
100Osteolytic defects of the hand bones (HP:0009699)1.79327702
101Hepatocellular carcinoma (HP:0001402)1.76836794
102Exostoses (HP:0100777)1.76815932
103Interstitial pulmonary disease (HP:0006530)1.76539075
104Aortic aneurysm (HP:0004942)1.76473105
105Xanthomatosis (HP:0000991)1.76178931
106Abnormality of purine metabolism (HP:0004352)1.76026977
107Ankyloglossia (HP:0010296)1.75189734
108Uterine neoplasm (HP:0010784)1.74528464
109Truncal obesity (HP:0001956)1.74226147
110Retinal atrophy (HP:0001105)1.73902428
111Inappropriate behavior (HP:0000719)1.73884736
112Long toe (HP:0010511)1.73841080
113Relative macrocephaly (HP:0004482)1.73058624
114Abnormality of the epiphyses of the hand (HP:0005924)1.72762106
115Resting tremor (HP:0002322)1.72652470
116Abnormal hair whorl (HP:0010721)1.70569138
117Abnormal glucose tolerance (HP:0001952)1.70436324
118Cubitus valgus (HP:0002967)1.70408081
119Abnormality of the ischium (HP:0003174)1.70275229
120Abnormal biliary tract morphology (HP:0012440)1.70188882
121Global brain atrophy (HP:0002283)1.69989828
122Lymphangioma (HP:0100764)1.69301165
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.69203597
124Hypoplastic ischia (HP:0003175)1.69009806
125Increased CSF protein (HP:0002922)1.68775966
126Uterine leiomyosarcoma (HP:0002891)1.68723347
127Leiomyosarcoma (HP:0100243)1.68723347
128Coarse hair (HP:0002208)1.68214585
129Symptomatic seizures (HP:0011145)1.67581873
130Clitoromegaly (HP:0000057)1.66544337
131Abnormality of chromosome segregation (HP:0002916)1.66282706
132Chorioretinal atrophy (HP:0000533)1.66137915
133Tapered finger (HP:0001182)1.65925056
134Abnormality of the gastric mucosa (HP:0004295)1.65852121
135Generalized hypopigmentation of hair (HP:0011358)1.65698715
136Asymmetry of the thorax (HP:0001555)1.65509902
137Narrow palate (HP:0000189)1.65404646
138Gonadotropin excess (HP:0000837)1.64973758
139Abnormality of the axillary hair (HP:0100134)1.64350181
140Abnormality of secondary sexual hair (HP:0009888)1.64350181
141Obsessive-compulsive behavior (HP:0000722)1.64233628
142Ketosis (HP:0001946)1.64107890
143Focal segmental glomerulosclerosis (HP:0000097)1.62979981
144Chronic diarrhea (HP:0002028)1.62676593
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.62635734
146Urinary bladder sphincter dysfunction (HP:0002839)1.62629213
147Gastrointestinal infarctions (HP:0005244)1.62282172
148Genetic anticipation (HP:0003743)1.61608553
149Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.61568425
150Male infertility (HP:0003251)1.61191871
151Urethral obstruction (HP:0000796)1.59937289
152Acute lymphatic leukemia (HP:0006721)1.59880978
153Neoplasm of the thyroid gland (HP:0100031)1.59766119
154Tubulointerstitial nephritis (HP:0001970)1.59629487
155Skin nodule (HP:0200036)1.59621935
156Disinhibition (HP:0000734)1.59137635
157Fat malabsorption (HP:0002630)1.59074395
158Subcapsular cataract (HP:0000523)1.58418461
159Absent frontal sinuses (HP:0002688)1.57785468
160Abnormality of monocarboxylic acid metabolism (HP:0010996)1.57405059
161Cone-rod dystrophy (HP:0000548)1.56976750
162Arterial tortuosity (HP:0005116)1.56213032
163Thoracolumbar scoliosis (HP:0002944)1.53788190
164Acute myeloid leukemia (HP:0004808)1.53465699
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53402269
166Buphthalmos (HP:0000557)1.52816488
167Polycythemia (HP:0001901)1.52663506
168Eczematoid dermatitis (HP:0000976)1.52139681
169Cerebral inclusion bodies (HP:0100314)1.51527478
170Chest pain (HP:0100749)1.51321460
171Excessive salivation (HP:0003781)1.50795096
172Drooling (HP:0002307)1.50795096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.31757714
2LATS13.89466320
3ACVR1B3.34619579
4TAOK33.27892902
5AKT32.27427114
6INSRR2.21601704
7FGFR32.20314101
8CAMK1G2.14775995
9MAP3K22.08713672
10NLK2.03832217
11FGFR21.99360362
12MKNK21.86504735
13CDK121.81044512
14YES11.71608595
15TRIB31.68913734
16PKN21.67649483
17CAMK1D1.67445869
18RIPK11.64454167
19PTK61.62171845
20STK31.54942353
21KSR21.50721897
22JAK11.49787732
23MAP3K91.36475891
24RET1.36144132
25CDK191.35778421
26BRSK21.33185054
27JAK31.30870465
28TEC1.30208462
29SCYL21.29728576
30MAP3K41.27498458
31PDGFRA1.26723975
32SGK31.24640808
33MKNK11.21751374
34DMPK1.19280597
35PRKD31.19066283
36FGFR41.18488000
37TNIK1.18428878
38TTK1.18292267
39TTN1.15244156
40NUAK11.14604769
41RIPK41.13330115
42PDGFRB1.10503377
43WNK11.09208941
44SIK11.08816680
45CASK1.08546082
46EEF2K1.06208745
47PRKCH1.05604492
48HIPK21.05495942
49TSSK61.03950795
50MET1.01464287
51MAP3K130.98920568
52PIK3CG0.98379523
53MAP3K70.97726586
54JAK20.97110880
55MAP3K10.95127657
56MAP2K40.95009235
57OXSR10.94713565
58RPS6KB20.91260608
59SGK20.89106724
60LMTK20.88744426
61CDK60.88199738
62STK38L0.86745503
63EPHB10.86145821
64STK380.85887864
65NEK60.85525961
66FGFR10.85463198
67PDK10.79369206
68MST1R0.77381353
69PRKAA20.76455588
70PASK0.74988959
71LATS20.74488799
72PRKAA10.74368164
73MAP3K100.73294383
74ERN10.73039165
75ERBB20.72698710
76PDPK10.70978079
77BTK0.69438102
78WNK40.69016474
79CSK0.68881876
80SIK20.68752081
81PTK20.68005149
82ATM0.67579646
83MAP3K60.67345092
84TAOK10.67182096
85MELK0.66770686
86TRPM70.65962133
87MTOR0.64207853
88MAP3K140.63467656
89PAK30.63425427
90CDK90.63170032
91FER0.62606365
92FGR0.61696644
93PIK3CA0.61436591
94STK390.61233785
95TYK20.61063660
96STK110.60537887
97STK240.59799270
98RPS6KB10.59633037
99ERBB40.59500803
100STK100.59094734
101ALK0.59093971
102SGK10.58433823
103CDC42BPA0.55159254
104CDK40.55066478
105ITK0.52318789
106MST40.51703110
107NTRK30.51547685
108EPHA30.51541333
109PRKCQ0.51387939
110CAMKK10.51006263
111STK40.50764909
112PLK40.50369873
113SGK2230.49320692
114SGK4940.49320692
115PNCK0.47656751
116EGFR0.47541163
117MARK20.46599652
118BMPR20.46350877
119CHEK10.46121579
120LRRK20.46015993
121PRKD10.45245987
122DYRK30.43074980
123RPS6KA40.42382938
124MAPK100.42373550
125MAP4K10.41869537
126EIF2AK30.41859508
127NEK90.40884405
128IRAK10.40730409
129ERBB30.40504096
130CSNK1A1L0.40047522
131CSNK1G20.39941297
132BRD40.39442056
133ABL10.39186227
134PIM10.38799226
135CSNK1D0.37017290
136CAMK40.36060009
137HCK0.35892281
138ICK0.35076591
139KSR10.33619162
140PTK2B0.32878969
141CHUK0.32368440

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.24027080
2Thyroid cancer_Homo sapiens_hsa052161.98735310
3Nitrogen metabolism_Homo sapiens_hsa009101.96859235
4Type II diabetes mellitus_Homo sapiens_hsa049301.73863426
5Dorso-ventral axis formation_Homo sapiens_hsa043201.71432576
6Non-homologous end-joining_Homo sapiens_hsa034501.68672924
7Acute myeloid leukemia_Homo sapiens_hsa052211.55316317
8Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52122326
9Colorectal cancer_Homo sapiens_hsa052101.49024221
10Lysine degradation_Homo sapiens_hsa003101.45787871
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38137673
12Insulin resistance_Homo sapiens_hsa049311.36963825
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35196162
14Sulfur metabolism_Homo sapiens_hsa009201.28434971
15Bile secretion_Homo sapiens_hsa049761.28030610
16Arginine biosynthesis_Homo sapiens_hsa002201.20528933
17mTOR signaling pathway_Homo sapiens_hsa041501.20201761
18Insulin secretion_Homo sapiens_hsa049111.20178444
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16439847
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15071457
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15023225
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13693457
23ABC transporters_Homo sapiens_hsa020101.12460021
24mRNA surveillance pathway_Homo sapiens_hsa030151.11155780
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11152726
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08314408
27Prolactin signaling pathway_Homo sapiens_hsa049171.03679011
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03270394
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.02384553
30Pancreatic cancer_Homo sapiens_hsa052121.02262394
31Long-term potentiation_Homo sapiens_hsa047201.01899122
32Endometrial cancer_Homo sapiens_hsa052131.00987491
33Tight junction_Homo sapiens_hsa045301.00009655
34Thyroid hormone synthesis_Homo sapiens_hsa049180.99392947
35Pancreatic secretion_Homo sapiens_hsa049720.98779836
36Jak-STAT signaling pathway_Homo sapiens_hsa046300.97361581
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97029400
38Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96861678
39Renin secretion_Homo sapiens_hsa049240.94332787
40Inositol phosphate metabolism_Homo sapiens_hsa005620.93841285
41Adherens junction_Homo sapiens_hsa045200.93097178
42Glioma_Homo sapiens_hsa052140.92639276
43Estrogen signaling pathway_Homo sapiens_hsa049150.92425893
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91110959
45Glucagon signaling pathway_Homo sapiens_hsa049220.90994534
46Gastric acid secretion_Homo sapiens_hsa049710.90616174
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89734430
48Measles_Homo sapiens_hsa051620.86858153
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86856761
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86589132
51Phototransduction_Homo sapiens_hsa047440.86249579
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84518567
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82292040
54Non-small cell lung cancer_Homo sapiens_hsa052230.82118261
55Fat digestion and absorption_Homo sapiens_hsa049750.81870203
56Starch and sucrose metabolism_Homo sapiens_hsa005000.81661076
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.81493625
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.80555885
59Hepatitis B_Homo sapiens_hsa051610.80229337
60Melanoma_Homo sapiens_hsa052180.80142081
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79639530
62Tryptophan metabolism_Homo sapiens_hsa003800.77954034
63Toxoplasmosis_Homo sapiens_hsa051450.77577693
64Cell cycle_Homo sapiens_hsa041100.77518599
65Viral carcinogenesis_Homo sapiens_hsa052030.77257201
66TGF-beta signaling pathway_Homo sapiens_hsa043500.77039277
67Chronic myeloid leukemia_Homo sapiens_hsa052200.76896260
68Prostate cancer_Homo sapiens_hsa052150.76510171
69GnRH signaling pathway_Homo sapiens_hsa049120.76128959
70Pathways in cancer_Homo sapiens_hsa052000.75990523
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.75798244
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75378860
73VEGF signaling pathway_Homo sapiens_hsa043700.74882592
74Salivary secretion_Homo sapiens_hsa049700.74463316
75B cell receptor signaling pathway_Homo sapiens_hsa046620.74111761
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74031460
77Cholinergic synapse_Homo sapiens_hsa047250.73528831
78Osteoclast differentiation_Homo sapiens_hsa043800.73061836
79Fatty acid degradation_Homo sapiens_hsa000710.72817303
80FoxO signaling pathway_Homo sapiens_hsa040680.72090033
81Renal cell carcinoma_Homo sapiens_hsa052110.71984023
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71977494
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71827478
84Insulin signaling pathway_Homo sapiens_hsa049100.71629139
85Renin-angiotensin system_Homo sapiens_hsa046140.71460714
86Caffeine metabolism_Homo sapiens_hsa002320.70791941
87Platelet activation_Homo sapiens_hsa046110.69711984
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68403953
89Long-term depression_Homo sapiens_hsa047300.67336256
90AMPK signaling pathway_Homo sapiens_hsa041520.66673829
91Choline metabolism in cancer_Homo sapiens_hsa052310.65485768
92Chemokine signaling pathway_Homo sapiens_hsa040620.64999441
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64840925
94p53 signaling pathway_Homo sapiens_hsa041150.64299850
95TNF signaling pathway_Homo sapiens_hsa046680.64209559
96Wnt signaling pathway_Homo sapiens_hsa043100.63888403
97cAMP signaling pathway_Homo sapiens_hsa040240.63560317
98Amoebiasis_Homo sapiens_hsa051460.63399233
99Dopaminergic synapse_Homo sapiens_hsa047280.63351035
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63268788
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63253194
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62515632
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.62260483
104RNA transport_Homo sapiens_hsa030130.62090297
105Focal adhesion_Homo sapiens_hsa045100.62003527
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.61148887
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61132328
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60830742
109Complement and coagulation cascades_Homo sapiens_hsa046100.60069628
110Circadian rhythm_Homo sapiens_hsa047100.59943735
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.59884196
112PPAR signaling pathway_Homo sapiens_hsa033200.59718555
113Rap1 signaling pathway_Homo sapiens_hsa040150.59685739
114ErbB signaling pathway_Homo sapiens_hsa040120.59257616
115Mineral absorption_Homo sapiens_hsa049780.58230973
116Ras signaling pathway_Homo sapiens_hsa040140.58142166
117Amphetamine addiction_Homo sapiens_hsa050310.57758288
118Proteoglycans in cancer_Homo sapiens_hsa052050.57298803
119Circadian entrainment_Homo sapiens_hsa047130.56887222
120Influenza A_Homo sapiens_hsa051640.56344987
121Cocaine addiction_Homo sapiens_hsa050300.55862049
122Oxytocin signaling pathway_Homo sapiens_hsa049210.55090387
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54705291
124HIF-1 signaling pathway_Homo sapiens_hsa040660.54397234
125Basal transcription factors_Homo sapiens_hsa030220.53699044
126Fatty acid biosynthesis_Homo sapiens_hsa000610.53594907
127Selenocompound metabolism_Homo sapiens_hsa004500.53297085
128Butanoate metabolism_Homo sapiens_hsa006500.52810316
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51555308
130Notch signaling pathway_Homo sapiens_hsa043300.51535894
131Hepatitis C_Homo sapiens_hsa051600.50485862
132Small cell lung cancer_Homo sapiens_hsa052220.50266600
133Leishmaniasis_Homo sapiens_hsa051400.50207961
134ECM-receptor interaction_Homo sapiens_hsa045120.50066874
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.49919328
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49470189
137Hippo signaling pathway_Homo sapiens_hsa043900.48320358
138Type I diabetes mellitus_Homo sapiens_hsa049400.48306766
139Glycerolipid metabolism_Homo sapiens_hsa005610.48143921
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47886063
141T cell receptor signaling pathway_Homo sapiens_hsa046600.47808583
142MicroRNAs in cancer_Homo sapiens_hsa052060.47718792
143Histidine metabolism_Homo sapiens_hsa003400.47099810
144MAPK signaling pathway_Homo sapiens_hsa040100.46871437
145Sphingolipid metabolism_Homo sapiens_hsa006000.45502798

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