ARFGEF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.79567777
2embryonic process involved in female pregnancy (GO:0060136)4.29106443
3alpha-linolenic acid metabolic process (GO:0036109)4.24131021
4COPII vesicle coating (GO:0048208)4.19907704
5urea metabolic process (GO:0019627)4.00235153
6urea cycle (GO:0000050)4.00235153
7desmosome organization (GO:0002934)3.96214742
8nuclear pore organization (GO:0006999)3.86513675
9regulation of cholesterol homeostasis (GO:2000188)3.83480410
10L-phenylalanine catabolic process (GO:0006559)3.83232962
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.83232962
12macroautophagy (GO:0016236)3.73240998
13lysine metabolic process (GO:0006553)3.68238141
14lysine catabolic process (GO:0006554)3.68238141
15dicarboxylic acid biosynthetic process (GO:0043650)3.63326152
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.62433114
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60369566
18L-phenylalanine metabolic process (GO:0006558)3.60369566
19cysteine metabolic process (GO:0006534)3.53556847
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53323821
21nitrogen cycle metabolic process (GO:0071941)3.52968551
22regulation of RNA export from nucleus (GO:0046831)3.52289763
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.50987987
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48585545
25regulation of fatty acid beta-oxidation (GO:0031998)3.43686769
26fatty acid transmembrane transport (GO:1902001)3.39451751
27pore complex assembly (GO:0046931)3.38473360
28carnitine shuttle (GO:0006853)3.34634970
29regulation of nucleobase-containing compound transport (GO:0032239)3.32813362
30phospholipid homeostasis (GO:0055091)3.32013166
31protein-lipid complex assembly (GO:0065005)3.27368190
32protein carboxylation (GO:0018214)3.23227225
33peptidyl-glutamic acid carboxylation (GO:0017187)3.23227225
34low-density lipoprotein particle clearance (GO:0034383)3.22220234
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21485951
362-oxoglutarate metabolic process (GO:0006103)3.20898297
37positive regulation of lipid catabolic process (GO:0050996)3.20370995
38negative regulation of fatty acid transport (GO:2000192)3.17646459
39vesicle coating (GO:0006901)3.17272509
40plasma lipoprotein particle assembly (GO:0034377)3.16462815
41sulfur amino acid catabolic process (GO:0000098)3.16217535
42negative regulation of fibrinolysis (GO:0051918)3.14095192
43cell adhesion mediated by integrin (GO:0033627)3.11344354
44retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08516103
45glutamate metabolic process (GO:0006536)3.07301816
46valine metabolic process (GO:0006573)3.07049338
47aromatic amino acid family catabolic process (GO:0009074)3.05632477
48acetyl-CoA metabolic process (GO:0006084)3.03750286
49hypotonic response (GO:0006971)3.02166017
50ethanol oxidation (GO:0006069)3.01936835
51positive regulation of histone deacetylation (GO:0031065)3.01829692
52regulation of histone H3-K27 methylation (GO:0061085)3.01151071
53regulation of triglyceride catabolic process (GO:0010896)2.97436946
54plasma lipoprotein particle clearance (GO:0034381)2.97415851
55cell-substrate junction assembly (GO:0007044)2.96276649
56kynurenine metabolic process (GO:0070189)2.96250662
57iron ion import (GO:0097286)2.94878106
58positive regulation of fatty acid oxidation (GO:0046321)2.93509885
59protein localization to endosome (GO:0036010)2.93337958
60cell-substrate adherens junction assembly (GO:0007045)2.91973269
61focal adhesion assembly (GO:0048041)2.91973269
62regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.91824164
63high-density lipoprotein particle remodeling (GO:0034375)2.90328719
64phospholipid efflux (GO:0033700)2.90210386
65complement activation, alternative pathway (GO:0006957)2.90194898
66pinocytosis (GO:0006907)2.89188056
67cholesterol efflux (GO:0033344)2.87281761
68L-alpha-amino acid transmembrane transport (GO:1902475)2.86996718
69homocysteine metabolic process (GO:0050667)2.86854768
70fatty acid homeostasis (GO:0055089)2.86521071
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86095245
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.86061256
73regulation of protein activation cascade (GO:2000257)2.85102170
74skin morphogenesis (GO:0043589)2.84858390
75sodium ion export (GO:0071436)2.84224613
76bile acid biosynthetic process (GO:0006699)2.82810912
77amino-acid betaine metabolic process (GO:0006577)2.82191078
78negative regulation of sterol transport (GO:0032372)2.82176386
79negative regulation of cholesterol transport (GO:0032375)2.82176386
80very-low-density lipoprotein particle assembly (GO:0034379)2.80197229
81positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.79004860
82short-chain fatty acid metabolic process (GO:0046459)2.77314631
83negative regulation of protein localization to plasma membrane (GO:1903077)2.77066833
84negative regulation of organelle assembly (GO:1902116)2.76345307
85response to methylmercury (GO:0051597)2.76116525
86adherens junction assembly (GO:0034333)2.76085610
87glyoxylate metabolic process (GO:0046487)2.74898724
88negative regulation of lipid transport (GO:0032369)2.74272817
89fatty acid beta-oxidation (GO:0006635)2.74095189
90aspartate family amino acid catabolic process (GO:0009068)2.73797462
91cellular response to ethanol (GO:0071361)2.73371208
92regulation of fatty acid oxidation (GO:0046320)2.72113094
93intracellular lipid transport (GO:0032365)2.71096811
94tricarboxylic acid metabolic process (GO:0072350)2.70842273
95regulation of apoptotic cell clearance (GO:2000425)2.70505682
96regulation of cholesterol storage (GO:0010885)2.70086301
97reverse cholesterol transport (GO:0043691)2.69999317
98negative regulation of DNA repair (GO:0045738)2.69598556
99regulation of complement activation (GO:0030449)2.69251842
100fatty acid oxidation (GO:0019395)2.69174798
101carnitine transmembrane transport (GO:1902603)2.69028396
102intestinal cholesterol absorption (GO:0030299)2.67349778
103branching involved in mammary gland duct morphogenesis (GO:0060444)2.67072876
104positive regulation of nuclease activity (GO:0032075)2.66299627
105epithelial cell-cell adhesion (GO:0090136)2.64931075
106negative regulation of fatty acid biosynthetic process (GO:0045717)2.64488556
107regulation of fibrinolysis (GO:0051917)2.64436081
108cellular modified amino acid catabolic process (GO:0042219)2.64356131
109receptor catabolic process (GO:0032801)2.64238460
110hemidesmosome assembly (GO:0031581)2.63879366
111serine family amino acid catabolic process (GO:0009071)2.63615364
112amino-acid betaine transport (GO:0015838)2.63516833
113carnitine transport (GO:0015879)2.63516833
114lipid oxidation (GO:0034440)2.63362520
115acylglycerol homeostasis (GO:0055090)2.61944457
116triglyceride homeostasis (GO:0070328)2.61944457
117bile acid metabolic process (GO:0008206)2.61829448
118histone H3-K36 demethylation (GO:0070544)2.61569213
119regulation of glucose import in response to insulin stimulus (GO:2001273)2.61334036
120regulation of early endosome to late endosome transport (GO:2000641)2.60684057
121positive regulation of triglyceride metabolic process (GO:0090208)2.60367588
122Golgi organization (GO:0007030)2.59690902
123regulation of transforming growth factor beta1 production (GO:0032908)2.59370450
124import into cell (GO:0098657)2.57540250
125activation of Rac GTPase activity (GO:0032863)2.57135262
126mitotic sister chromatid cohesion (GO:0007064)2.56248156
127regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.55332025
128embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55280797
129fatty acid catabolic process (GO:0009062)2.53817873
130Golgi transport vesicle coating (GO:0048200)2.53562205
131COPI coating of Golgi vesicle (GO:0048205)2.53562205
132regulation of steroid hormone biosynthetic process (GO:0090030)2.53294635
133regulation of lipid catabolic process (GO:0050994)2.53187120
134sterol homeostasis (GO:0055092)2.52911735
135protein-lipid complex subunit organization (GO:0071825)2.52056809
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50828637
137cholesterol homeostasis (GO:0042632)2.50402176
1384-hydroxyproline metabolic process (GO:0019471)2.50231866
139regulation of fatty acid biosynthetic process (GO:0042304)2.50113177
140positive regulation of extracellular matrix organization (GO:1903055)2.49946058
141positive regulation of triglyceride biosynthetic process (GO:0010867)2.47955140
142endoplasmic reticulum unfolded protein response (GO:0030968)2.46882258
143ER-nucleus signaling pathway (GO:0006984)2.46879650
144protein targeting to Golgi (GO:0000042)2.46726319
145regulation of protein polyubiquitination (GO:1902914)2.45773496
146embryonic camera-type eye morphogenesis (GO:0048596)2.45286115
147positive regulation of hormone metabolic process (GO:0032352)2.44929818
148positive regulation of cellular response to insulin stimulus (GO:1900078)2.44645713
149positive regulation of hormone biosynthetic process (GO:0046886)2.43462948
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.41200513
151negative regulation of anoikis (GO:2000811)2.38780204
152mammary gland epithelial cell proliferation (GO:0033598)2.37840253
153lipid translocation (GO:0034204)2.37749726
154phospholipid translocation (GO:0045332)2.37749726
155regulation of cholesterol biosynthetic process (GO:0045540)2.35650293
156cytoplasmic mRNA processing body assembly (GO:0033962)2.35342004
157peptidyl-threonine modification (GO:0018210)2.35020372
158regulation of transforming growth factor beta2 production (GO:0032909)2.34442356
159positive regulation of keratinocyte differentiation (GO:0045618)2.33234300
160cellular response to epidermal growth factor stimulus (GO:0071364)2.33079203
161phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.31502517
162response to epidermal growth factor (GO:0070849)2.31009985
163maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30122290
164intestinal absorption (GO:0050892)2.28593869
165mannose metabolic process (GO:0006013)2.26576949
166regulation of water loss via skin (GO:0033561)2.25784008
167basement membrane organization (GO:0071711)2.25767971
168peptidyl-lysine dimethylation (GO:0018027)2.25657032
169regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.25535796
170response to laminar fluid shear stress (GO:0034616)2.25190155
171embryonic eye morphogenesis (GO:0048048)2.24097664
172histone H3-K9 demethylation (GO:0033169)2.23525958
173negative regulation of protein activation cascade (GO:2000258)2.23404922
174peptidyl-threonine phosphorylation (GO:0018107)2.23249139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.61162545
2GATA1_22025678_ChIP-Seq_K562_Human4.76016198
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.32992504
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92436873
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.76716766
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.64128068
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18941804
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.80323250
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69068252
10E2F7_22180533_ChIP-Seq_HELA_Human2.57691869
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47758446
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44047364
13GATA1_19941826_ChIP-Seq_K562_Human2.43849992
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38468529
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20266949
16AR_21909140_ChIP-Seq_LNCAP_Human2.17665902
17ZNF263_19887448_ChIP-Seq_K562_Human1.99952980
18CLOCK_20551151_ChIP-Seq_293T_Human1.96523897
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94646214
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90865007
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82514270
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82514270
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79956584
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.74757343
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.74625140
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.74398285
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73563682
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71280965
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61723193
30GATA2_19941826_ChIP-Seq_K562_Human1.60259793
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.59477634
32AHR_22903824_ChIP-Seq_MCF-7_Human1.56653204
33KDM2B_26808549_Chip-Seq_DND41_Human1.50082481
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49879998
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49836813
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48480980
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.47137032
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45219879
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43883535
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43423712
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43287466
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43072634
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42855663
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.42762936
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42431591
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41196508
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39616231
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38310836
49TCF7_22412390_ChIP-Seq_EML_Mouse1.36700656
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.35236359
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34764744
52KDM2B_26808549_Chip-Seq_K562_Human1.34507289
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32683950
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27062342
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25946672
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.24852900
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.24852900
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23965720
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23335558
60RACK7_27058665_Chip-Seq_MCF-7_Human1.22907584
61GATA3_24758297_ChIP-Seq_MCF-7_Human1.22691864
62SOX2_20726797_ChIP-Seq_SW620_Human1.22647784
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20947240
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20413017
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19702152
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18947982
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18844054
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18526710
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18056471
70* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17423666
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.17363493
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16406114
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.16366447
74* GATA2_21666600_ChIP-Seq_HMVEC_Human1.16132257
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13344241
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.13164772
77ATF3_27146783_Chip-Seq_COLON_Human1.12696723
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12407056
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.12307738
80CREB1_26743006_Chip-Seq_LNCaP_Human1.11759611
81* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11510215
82* GATA6_25053715_ChIP-Seq_YYC3_Human1.11455843
83* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10797380
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10307837
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09913903
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09728820
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09437119
88CHD1_26751641_Chip-Seq_LNCaP_Human1.09081598
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08768084
90LXR_22292898_ChIP-Seq_THP-1_Human1.08614985
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.07491989
92* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07318634
93* TFEB_21752829_ChIP-Seq_HELA_Human1.07030859
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06901869
95MYC_22102868_ChIP-Seq_BL_Human1.06353777
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06260813
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06248812
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06074493
99* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05926987
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05912599
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.05364557
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04498833
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.04210769
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04123613
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03736102
106BRD4_25478319_ChIP-Seq_HGPS_Human1.02791241
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.02110519
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01903530
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01343937
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01293336
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.00610984
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00362264
113NCOR1_26117541_ChIP-Seq_K562_Human1.00332017
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00225126
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.99698899
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98874672
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97898359
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96336777
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96191243
120SPI1_23127762_ChIP-Seq_K562_Human0.95346084
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95209860
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.95125720
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94094585
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93939318
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92771060
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91993215
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87726405
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85984829
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85913758
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85278105
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84357751
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84214742
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.83360845
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83008257
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82953306
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.81861234
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80602788
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78542221
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78542221
140MAF_26560356_Chip-Seq_TH1_Human0.78296851
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78268618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.74497664
2MP0005360_urolithiasis4.60054311
3MP0005365_abnormal_bile_salt3.64476342
4MP0005085_abnormal_gallbladder_physiolo3.56266794
5MP0005083_abnormal_biliary_tract3.19564360
6MP0003705_abnormal_hypodermis_morpholog3.09265301
7MP0005451_abnormal_body_composition2.94074689
8MP0003252_abnormal_bile_duct2.76604822
9MP0010329_abnormal_lipoprotein_level2.74607890
10MP0009840_abnormal_foam_cell2.66455818
11MP0005409_darkened_coat_color2.65791840
12MP0008057_abnormal_DNA_replication2.53994188
13MP0003300_gastrointestinal_ulcer2.52683453
14MP0003656_abnormal_erythrocyte_physiolo2.50705460
15MP0008875_abnormal_xenobiotic_pharmacok2.48713172
16MP0004130_abnormal_muscle_cell2.36957529
17MP0002009_preneoplasia2.28570969
18MP0002877_abnormal_melanocyte_morpholog2.22216814
19MP0005408_hypopigmentation2.06051466
20MP0003806_abnormal_nucleotide_metabolis2.04760324
21MP0004185_abnormal_adipocyte_glucose2.03323477
22MP0010234_abnormal_vibrissa_follicle2.02132523
23MP0003172_abnormal_lysosome_physiology2.01102821
24MP0002118_abnormal_lipid_homeostasis1.94099389
25MP0000609_abnormal_liver_physiology1.92305155
26MP0005058_abnormal_lysosome_morphology1.88949650
27MP0003950_abnormal_plasma_membrane1.87159086
28MP0003195_calcinosis1.86585004
29MP0002837_dystrophic_cardiac_calcinosis1.85799779
30MP0003191_abnormal_cellular_cholesterol1.85568194
31MP0001666_abnormal_nutrient_absorption1.84530043
32MP0005670_abnormal_white_adipose1.79512812
33MP0004233_abnormal_muscle_weight1.76150605
34MP0009780_abnormal_chondrocyte_physiolo1.75821155
35MP0005666_abnormal_adipose_tissue1.72658891
36MP0002166_altered_tumor_susceptibility1.70372290
37MP0008961_abnormal_basal_metabolism1.63256937
38MP0010678_abnormal_skin_adnexa1.61668130
39MP0002796_impaired_skin_barrier1.58330056
40MP0005332_abnormal_amino_acid1.56258535
41MP0005257_abnormal_intraocular_pressure1.54194118
42MP0005375_adipose_tissue_phenotype1.47735456
43MP0002396_abnormal_hematopoietic_system1.45664720
44MP0002909_abnormal_adrenal_gland1.42445536
45MP0004510_myositis1.41202406
46MP0003566_abnormal_cell_adhesion1.38565429
47MP0004272_abnormal_basement_membrane1.34703677
48MP0000569_abnormal_digit_pigmentation1.34654770
49MP0000003_abnormal_adipose_tissue1.32805306
50MP0000604_amyloidosis1.31345297
51MP0002971_abnormal_brown_adipose1.31338736
52MP0002254_reproductive_system_inflammat1.30856091
53MP0001915_intracranial_hemorrhage1.30014490
54MP0002078_abnormal_glucose_homeostasis1.29983142
55MP0005319_abnormal_enzyme/_coenzyme1.27806147
56MP0003045_fibrosis1.27442374
57MP0002060_abnormal_skin_morphology1.27341700
58MP0008004_abnormal_stomach_pH1.26530797
59MP0003941_abnormal_skin_development1.25560429
60MP0005076_abnormal_cell_differentiation1.24127619
61MP0004084_abnormal_cardiac_muscle1.22768784
62MP0010352_gastrointestinal_tract_polyps1.22352714
63MP0003329_amyloid_beta_deposits1.18046125
64MP0004264_abnormal_extraembryonic_tissu1.17567754
65MP0002086_abnormal_extraembryonic_tissu1.15619914
66MP0005621_abnormal_cell_physiology1.14644238
67MP0003868_abnormal_feces_composition1.13951347
68MP0002269_muscular_atrophy1.13278175
69MP0002006_tumorigenesis1.11728417
70MP0009643_abnormal_urine_homeostasis1.11697548
71MP0005584_abnormal_enzyme/coenzyme_acti1.09315218
72MP0000627_abnormal_mammary_gland1.09166708
73MP0005334_abnormal_fat_pad1.07561078
74MP0008775_abnormal_heart_ventricle1.07288711
75MP0004808_abnormal_hematopoietic_stem1.07084778
76MP0000371_diluted_coat_color1.06387665
77MP0001730_embryonic_growth_arrest1.06131625
78MP0000747_muscle_weakness1.04163962
79MP0001216_abnormal_epidermal_layer1.03267982
80MP0000598_abnormal_liver_morphology1.02893369
81MP0000013_abnormal_adipose_tissue1.00130915
82MP0003984_embryonic_growth_retardation0.99619430
83MP0003690_abnormal_glial_cell0.98440066
84MP0004036_abnormal_muscle_relaxation0.98365751
85MP0008260_abnormal_autophagy0.97854627
86MP0008438_abnormal_cutaneous_collagen0.97732497
87MP0004087_abnormal_muscle_fiber0.97429842
88MP0005448_abnormal_energy_balance0.96845375
89MP0010368_abnormal_lymphatic_system0.96648215
90MP0003303_peritoneal_inflammation0.96333524
91MP0010307_abnormal_tumor_latency0.96293733
92MP0005464_abnormal_platelet_physiology0.96045136
93MP0002088_abnormal_embryonic_growth/wei0.95684865
94MP0005501_abnormal_skin_physiology0.95286900
95MP0001849_ear_inflammation0.95128230
96MP0002970_abnormal_white_adipose0.94260884
97MP0002098_abnormal_vibrissa_morphology0.94025789
98MP0000383_abnormal_hair_follicle0.93497053
99MP0000377_abnormal_hair_follicle0.93140390
100MP0004043_abnormal_pH_regulation0.92991645
101MP0005535_abnormal_body_temperature0.90455631
102MP0006138_congestive_heart_failure0.90131880
103MP0005310_abnormal_salivary_gland0.89830460
104MP0001672_abnormal_embryogenesis/_devel0.85946191
105MP0005380_embryogenesis_phenotype0.85946191
106MP0000733_abnormal_muscle_development0.85406221
107MP0000751_myopathy0.84446801
108MP0004947_skin_inflammation0.84217418
109MP0002138_abnormal_hepatobiliary_system0.81705806
110MP0001851_eye_inflammation0.81578684
111MP0003828_pulmonary_edema0.79854765
112MP0003453_abnormal_keratinocyte_physiol0.79846298
113MP0002089_abnormal_postnatal_growth/wei0.79486267
114MP0000767_abnormal_smooth_muscle0.78289391
115MP0002998_abnormal_bone_remodeling0.77028164
116MP0010630_abnormal_cardiac_muscle0.76280485
117MP0004019_abnormal_vitamin_homeostasis0.76228756
118MP0005384_cellular_phenotype0.75999676
119MP0009115_abnormal_fat_cell0.75669660
120MP0002168_other_aberrant_phenotype0.74953408
121MP0003091_abnormal_cell_migration0.74780121
122MP0005023_abnormal_wound_healing0.74408873
123MP0004859_abnormal_synaptic_plasticity0.74091337
124MP0004782_abnormal_surfactant_physiolog0.73676642
125MP0001756_abnormal_urination0.72481136
126MP0003183_abnormal_peptide_metabolism0.71732338
127MP0001661_extended_life_span0.71608684
128MP0005330_cardiomyopathy0.71424100
129MP0001348_abnormal_lacrimal_gland0.70583890
130MP0006054_spinal_hemorrhage0.68871410
131MP0003221_abnormal_cardiomyocyte_apopto0.68479387
132MP0009672_abnormal_birth_weight0.67384128
133MP0000350_abnormal_cell_proliferation0.66017628
134MP0004147_increased_porphyrin_level0.65084267
135MP0003763_abnormal_thymus_physiology0.64780552
136MP0000462_abnormal_digestive_system0.64762609
137MP0003943_abnormal_hepatobiliary_system0.64551736
138MP0000858_altered_metastatic_potential0.64496147
139MP0001944_abnormal_pancreas_morphology0.64228142
140MP0003646_muscle_fatigue0.63708239
141MP0003633_abnormal_nervous_system0.63604360
142MP0009642_abnormal_blood_homeostasis0.63483671
143MP0005167_abnormal_blood-brain_barrier0.62226518
144MP0002090_abnormal_vision0.62132414
145MP0005275_abnormal_skin_tensile0.62047822
146MP0004858_abnormal_nervous_system0.61862594
147MP0002693_abnormal_pancreas_physiology0.61396121
148MP0003283_abnormal_digestive_organ0.61170150
149MP0005636_abnormal_mineral_homeostasis0.59586754
150MP0002896_abnormal_bone_mineralization0.59197468
151MP0009763_increased_sensitivity_to0.58212725
152MP0001765_abnormal_ion_homeostasis0.58174437

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.09078650
2Xanthomatosis (HP:0000991)3.93774831
3Poikilocytosis (HP:0004447)3.79146250
4Intrahepatic cholestasis (HP:0001406)3.68999427
5Bilateral sensorineural hearing impairment (HP:0008619)3.68009419
6Flat acetabular roof (HP:0003180)3.62509572
7Acanthocytosis (HP:0001927)3.37339777
8Status epilepticus (HP:0002133)3.26280204
9Global brain atrophy (HP:0002283)3.19400682
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.14044854
11Hyperlipoproteinemia (HP:0010980)2.95777739
12Hypoglycemic coma (HP:0001325)2.92035814
13Abnormality of aromatic amino acid family metabolism (HP:0004338)2.87749270
14Reticulocytosis (HP:0001923)2.87206991
15Ketosis (HP:0001946)2.86460067
16Hypoalphalipoproteinemia (HP:0003233)2.81833961
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.79072076
18Osteolytic defects of the hand bones (HP:0009699)2.79072076
19Asymmetry of the thorax (HP:0001555)2.76870694
20Ankyloglossia (HP:0010296)2.70003457
21Epidermoid cyst (HP:0200040)2.67428820
22Resting tremor (HP:0002322)2.66804858
23Complement deficiency (HP:0004431)2.64885769
24Myocardial infarction (HP:0001658)2.62714913
25Papillary thyroid carcinoma (HP:0002895)2.61705365
26Abnormality of the common coagulation pathway (HP:0010990)2.61178566
27Cholelithiasis (HP:0001081)2.58796838
28Arterial tortuosity (HP:0005116)2.58723852
29Ketoacidosis (HP:0001993)2.56624109
30Hyporeflexia of lower limbs (HP:0002600)2.55119003
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54970862
32Abnormal gallbladder morphology (HP:0012437)2.53987218
33Hyperbilirubinemia (HP:0002904)2.53470305
34Skin nodule (HP:0200036)2.51566824
35Hyperammonemia (HP:0001987)2.50366965
36Hypolipoproteinemia (HP:0010981)2.49601992
37Hypobetalipoproteinemia (HP:0003563)2.44496821
38Macroorchidism (HP:0000053)2.44403002
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.40056266
40Subacute progressive viral hepatitis (HP:0006572)2.39655347
41Vertebral compression fractures (HP:0002953)2.35420907
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34061792
43Protrusio acetabuli (HP:0003179)2.32427113
44Abnormality of the intrinsic pathway (HP:0010989)2.32187282
45Polycythemia (HP:0001901)2.32013485
46Cerebral inclusion bodies (HP:0100314)2.31995711
47Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.30465301
48Increased CSF protein (HP:0002922)2.29876908
49Sparse lateral eyebrow (HP:0005338)2.28517548
50Abnormality of oral frenula (HP:0000190)2.24240508
51Upper limb amyotrophy (HP:0009129)2.23747122
52Distal upper limb amyotrophy (HP:0007149)2.23747122
53Abnormal foot bone ossification (HP:0010675)2.20835337
54Cerebral aneurysm (HP:0004944)2.20348893
55Dysmetric saccades (HP:0000641)2.19904371
56Hypercholesterolemia (HP:0003124)2.19666872
57Hyperinsulinemic hypoglycemia (HP:0000825)2.19601792
58Vascular tortuosity (HP:0004948)2.17776360
59Coarse hair (HP:0002208)2.17359301
60Hyperglycinuria (HP:0003108)2.17117085
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16498759
62Broad face (HP:0000283)2.15696263
63Abnormality of carpal bone ossification (HP:0006257)2.13088138
64Myoglobinuria (HP:0002913)2.12678971
65Hyperglycemia (HP:0003074)2.12446011
66Increased cerebral lipofuscin (HP:0011813)2.12245740
67Sensorimotor neuropathy (HP:0007141)2.12116882
68Deep philtrum (HP:0002002)2.11127494
69Advanced eruption of teeth (HP:0006288)2.09149158
70Cardiovascular calcification (HP:0011915)2.08514481
71Abnormality of the fingertips (HP:0001211)2.07970284
72Hand muscle atrophy (HP:0009130)2.07235313
73Vascular calcification (HP:0004934)2.06287461
74Back pain (HP:0003418)2.06262759
75Prolonged partial thromboplastin time (HP:0003645)2.05485184
76Abnormality of serine family amino acid metabolism (HP:0010894)2.03363912
77Abnormality of glycine metabolism (HP:0010895)2.03363912
78Abnormality of complement system (HP:0005339)2.02767093
79Mitral stenosis (HP:0001718)2.01530663
80Abnormality of the Achilles tendon (HP:0005109)2.01506478
81Hepatocellular carcinoma (HP:0001402)2.01187674
82Menorrhagia (HP:0000132)1.99952055
83Focal seizures (HP:0007359)1.98204584
84Aneurysm (HP:0002617)1.97565072
85Gout (HP:0001997)1.97170955
86Spinal cord lesions (HP:0100561)1.96910565
87Syringomyelia (HP:0003396)1.96910565
88Short nail (HP:0001799)1.95921075
89Abnormal ossification of hand bones (HP:0005921)1.95784692
90Distal lower limb amyotrophy (HP:0008944)1.94937743
91Hypoglycemic seizures (HP:0002173)1.94859703
92Hemorrhage of the eye (HP:0011885)1.94355598
93Relative macrocephaly (HP:0004482)1.94134788
94Hemiparesis (HP:0001269)1.94082076
95Abnormal tarsal ossification (HP:0008369)1.93863131
96Increased mean platelet volume (HP:0011877)1.93646093
97Abnormality of proline metabolism (HP:0010907)1.92531070
98Hydroxyprolinuria (HP:0003080)1.92531070
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.92332493
100Difficulty running (HP:0009046)1.92214370
101Right ventricular cardiomyopathy (HP:0011663)1.91038230
102Turricephaly (HP:0000262)1.90921131
103Neurofibrillary tangles (HP:0002185)1.90880350
104Conjugated hyperbilirubinemia (HP:0002908)1.90529256
105Hyperglycinemia (HP:0002154)1.90484336
106Hypercortisolism (HP:0001578)1.88670503
107Abnormality of purine metabolism (HP:0004352)1.88646835
108Severe Myopia (HP:0011003)1.85957099
109Supranuclear gaze palsy (HP:0000605)1.85644387
110Thin bony cortex (HP:0002753)1.85425408
111Hyperacusis (HP:0010780)1.85372842
112Abnormality of fatty-acid metabolism (HP:0004359)1.84853606
113Postural instability (HP:0002172)1.83109338
114Abnormal cartilage morphology (HP:0002763)1.83001559
115Esophageal varix (HP:0002040)1.82984927
116Abnormality of the gallbladder (HP:0005264)1.82842065
117Asymmetric septal hypertrophy (HP:0001670)1.82425585
118Abnormality of the acetabulum (HP:0003170)1.82033003
119Dislocated radial head (HP:0003083)1.81690601
120Curly hair (HP:0002212)1.80703645
121Bundle branch block (HP:0011710)1.80061681
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78461091
123Mitral valve prolapse (HP:0001634)1.77081034
124Long toe (HP:0010511)1.76833802
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76357828
126Abnormality of vision evoked potentials (HP:0000649)1.76145496
127Abnormality of the lower motor neuron (HP:0002366)1.76095537
128Aortic aneurysm (HP:0004942)1.75911019
129Increased connective tissue (HP:0009025)1.75335263
130Testicular atrophy (HP:0000029)1.74607344
131Termporal pattern (HP:0011008)1.73820029
132Insidious onset (HP:0003587)1.73820029
133Abnormal gallbladder physiology (HP:0012438)1.73780133
134Cholecystitis (HP:0001082)1.73780133
135Aortic dissection (HP:0002647)1.73683961
136Urinary glycosaminoglycan excretion (HP:0003541)1.73476996
137Mucopolysacchariduria (HP:0008155)1.73476996
138Premature rupture of membranes (HP:0001788)1.73309189
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72989142
140Fat malabsorption (HP:0002630)1.72776518
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72244701
142Achilles tendon contracture (HP:0001771)1.71868823
143Abnormal hand bone ossification (HP:0010660)1.71813585
144Lymphangioma (HP:0100764)1.71547283
145Abnormality of the nasal septum (HP:0000419)1.71245319
146Colitis (HP:0002583)1.68915103
147Narrow palate (HP:0000189)1.65745791
148Missing ribs (HP:0000921)1.65660318
149Micronodular cirrhosis (HP:0001413)1.65362686
150Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64339428
151Wormian bones (HP:0002645)1.63365625
152Abnormality of the radial head (HP:0003995)1.61863641
153Menstrual irregularities (HP:0000858)1.61353134
154* Heterotopia (HP:0002282)1.61190180
155Abnormality of the gastric mucosa (HP:0004295)1.61015177
156Germ cell neoplasia (HP:0100728)1.60921562
157Testicular neoplasm (HP:0010788)1.59898064
158Gingival bleeding (HP:0000225)1.59412014
159Bone pain (HP:0002653)1.59392621
160Neonatal death (HP:0003811)1.57316115
161Leiomyosarcoma (HP:0100243)1.56637192
162Uterine leiomyosarcoma (HP:0002891)1.56637192
163Cervical subluxation (HP:0003308)1.55432306
164Cubitus valgus (HP:0002967)1.55169301
165Hypopigmentation of the fundus (HP:0007894)1.54889979
166Thyroid carcinoma (HP:0002890)1.54218953
167Natal tooth (HP:0000695)1.53289218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.60873082
2TAOK33.09294697
3MST1R3.07939549
4PKN22.43848368
5ERN12.40186169
6SIK12.35111218
7AKT32.18209336
8SCYL22.05942487
9PRPF4B2.04936296
10EPHA21.99412712
11RIPK11.93841886
12CAMK1D1.85221139
13CAMK1G1.80604974
14EEF2K1.75703800
15MAP3K21.74921394
16CDK121.73073009
17PTK61.71941433
18TTN1.66031664
19PDGFRA1.64912482
20IRAK31.60955144
21MAP3K101.58950773
22PTK21.57706926
23LATS11.55481827
24TRPM71.53047599
25FGFR41.51256886
26KSR21.50288288
27SMG11.43417968
28BCKDK1.42196468
29BRD41.40862876
30ICK1.39347737
31RET1.39294030
32MAP3K91.31898182
33TAOK11.30116154
34EPHB11.29945156
35NEK61.28432811
36PDK31.27558709
37PDK41.27558709
38NTRK11.27401438
39MAP3K71.27388914
40DYRK1B1.22659313
41SGK31.21869032
42FRK1.18155888
43PRKD31.17489894
44STK381.15600726
45BMX1.15407089
46JAK21.14226088
47MELK1.12963991
48STK391.11918431
49MAP3K141.10793391
50JAK11.10324735
51PDGFRB1.08654736
52ALK1.06594703
53INSRR1.06447316
54MTOR1.05986318
55CDK61.04303290
56PDPK11.00715632
57RPS6KB21.00084192
58RIPK40.99877127
59WNK10.99768598
60LMTK20.98735473
61EIF2AK30.96894128
62PRKCH0.95053964
63ERBB40.94701759
64PRKAA10.94461875
65PDK10.94381228
66CAMKK10.93055987
67FGFR30.92517424
68STK240.90824655
69PBK0.89366201
70EIF2AK10.88750676
71FLT30.86672164
72MAP3K30.85622608
73PRKAA20.84178685
74LRRK20.82775609
75FGFR20.81147468
76MAP2K40.80225944
77DAPK20.79975169
78MAP3K10.79666046
79PIK3CA0.78447645
80MET0.76290923
81DMPK0.75288574
82STK30.73817789
83RPS6KA20.71808874
84SGK20.69963464
85PAK60.68673099
86PAK40.68272438
87BMPR20.66380640
88DDR20.66286270
89CDC42BPA0.65844147
90PAK30.65232980
91RPS6KB10.64915252
92PRKD10.64905856
93STK38L0.62681336
94LATS20.62270975
95HIPK20.62113609
96YES10.61959722
97TYRO30.61651833
98STK100.61423359
99PAK20.60417129
100MAP2K30.59229456
101MAP3K60.57461340
102CDK70.57393082
103STK110.56397429
104MARK20.54965394
105TYK20.54282832
106TGFBR20.54273579
107TBK10.54205019
108MAP2K10.54172441
109GRK60.52200538
110FGFR10.51449004
111CDK40.50698578
112STK40.50589366
113SGK2230.48986312
114SGK4940.48986312
115TSSK60.48910688
116MAP3K40.48628325
117WNK40.48554002
118FER0.48246149
119EPHA30.46880177
120NEK10.46488970
121NEK90.46002298
122PDK20.45881853
123SGK10.45165848
124EGFR0.44605138
125MAP3K130.43649296
126MAPK110.43623926
127MAPK100.43313642
128PRKD20.42772897
129PIK3CG0.42758063
130PRKACG0.42746302
131PTK2B0.39532155
132PRKCZ0.38807844
133KSR10.38758525
134HCK0.38697248
135* RPS6KA30.38648023
136CHUK0.36292127
137ZAP700.36051837
138MAP3K80.34205127
139NLK0.31919520
140ERBB20.30891695
141CHEK10.29030922
142AKT20.28919361
143RAF10.27828448

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.93282600
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23667829
3Arginine biosynthesis_Homo sapiens_hsa002202.52726035
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.51443298
5Fatty acid degradation_Homo sapiens_hsa000712.29880963
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04015724
7Other glycan degradation_Homo sapiens_hsa005111.94151789
8Tryptophan metabolism_Homo sapiens_hsa003801.89013012
9Thyroid cancer_Homo sapiens_hsa052161.87730945
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85032415
11Propanoate metabolism_Homo sapiens_hsa006401.84715672
12PPAR signaling pathway_Homo sapiens_hsa033201.83811776
13Fatty acid metabolism_Homo sapiens_hsa012121.78874081
14ABC transporters_Homo sapiens_hsa020101.78049219
15Bile secretion_Homo sapiens_hsa049761.75637797
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74682696
17Adherens junction_Homo sapiens_hsa045201.72882996
18Pancreatic cancer_Homo sapiens_hsa052121.66648470
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66550282
20Complement and coagulation cascades_Homo sapiens_hsa046101.54559453
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53014656
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52548971
23Butanoate metabolism_Homo sapiens_hsa006501.51838353
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50126713
25Renal cell carcinoma_Homo sapiens_hsa052111.47201691
26Caffeine metabolism_Homo sapiens_hsa002321.43090021
27Small cell lung cancer_Homo sapiens_hsa052221.39991562
28Lysine degradation_Homo sapiens_hsa003101.38736927
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37664079
30Fatty acid biosynthesis_Homo sapiens_hsa000611.32804907
31Acute myeloid leukemia_Homo sapiens_hsa052211.30933955
32Prostate cancer_Homo sapiens_hsa052151.30018788
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28158951
34Bladder cancer_Homo sapiens_hsa052191.24642397
35Insulin resistance_Homo sapiens_hsa049311.23570164
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.22223288
37ECM-receptor interaction_Homo sapiens_hsa045121.20800719
38Type II diabetes mellitus_Homo sapiens_hsa049301.18091777
39Pyruvate metabolism_Homo sapiens_hsa006201.17936200
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.17415135
41ErbB signaling pathway_Homo sapiens_hsa040121.17295610
42Vitamin B6 metabolism_Homo sapiens_hsa007501.13412758
43Glycerolipid metabolism_Homo sapiens_hsa005611.12405719
44Selenocompound metabolism_Homo sapiens_hsa004501.10609727
45MicroRNAs in cancer_Homo sapiens_hsa052061.09409810
46Fat digestion and absorption_Homo sapiens_hsa049751.07886277
47Carbon metabolism_Homo sapiens_hsa012001.06652149
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.05820228
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05061881
50Starch and sucrose metabolism_Homo sapiens_hsa005001.02210019
51Sphingolipid metabolism_Homo sapiens_hsa006001.00504055
52Peroxisome_Homo sapiens_hsa041460.99194124
53mTOR signaling pathway_Homo sapiens_hsa041500.96362757
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96152123
55HIF-1 signaling pathway_Homo sapiens_hsa040660.95182659
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93967717
57Choline metabolism in cancer_Homo sapiens_hsa052310.93029110
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.91625898
59GnRH signaling pathway_Homo sapiens_hsa049120.90541616
60AMPK signaling pathway_Homo sapiens_hsa041520.89676964
61beta-Alanine metabolism_Homo sapiens_hsa004100.87867646
62Platelet activation_Homo sapiens_hsa046110.86942893
63Long-term potentiation_Homo sapiens_hsa047200.86512130
64Glucagon signaling pathway_Homo sapiens_hsa049220.86474686
65Hepatitis C_Homo sapiens_hsa051600.86373526
66FoxO signaling pathway_Homo sapiens_hsa040680.86261700
67Insulin signaling pathway_Homo sapiens_hsa049100.82831166
68Biosynthesis of amino acids_Homo sapiens_hsa012300.82556876
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81664345
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81550743
71Staphylococcus aureus infection_Homo sapiens_hsa051500.77928218
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75871532
73Dorso-ventral axis formation_Homo sapiens_hsa043200.75437964
74Colorectal cancer_Homo sapiens_hsa052100.75375627
75Renin-angiotensin system_Homo sapiens_hsa046140.75190313
76Hepatitis B_Homo sapiens_hsa051610.75147270
77N-Glycan biosynthesis_Homo sapiens_hsa005100.75067196
78Histidine metabolism_Homo sapiens_hsa003400.74026355
79Sulfur metabolism_Homo sapiens_hsa009200.73801522
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73313319
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.71733478
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71729769
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69642491
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69383216
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68350562
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66862513
87Pentose phosphate pathway_Homo sapiens_hsa000300.66788310
88Phenylalanine metabolism_Homo sapiens_hsa003600.66746910
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65692926
90Viral carcinogenesis_Homo sapiens_hsa052030.65339682
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64770652
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63837491
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61260460
94Lysosome_Homo sapiens_hsa041420.59961648
95Toxoplasmosis_Homo sapiens_hsa051450.59584634
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.59030525
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58236595
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57618709
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57350376
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57159409
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57040214
102Circadian rhythm_Homo sapiens_hsa047100.56428513
103Chemical carcinogenesis_Homo sapiens_hsa052040.55641846
104TNF signaling pathway_Homo sapiens_hsa046680.55184891
105Vibrio cholerae infection_Homo sapiens_hsa051100.53411924
106Tight junction_Homo sapiens_hsa045300.52755866
107Influenza A_Homo sapiens_hsa051640.52511887
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.50286851
109Insulin secretion_Homo sapiens_hsa049110.48657299
110Salivary secretion_Homo sapiens_hsa049700.48314164
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48224120
112* Endocytosis_Homo sapiens_hsa041440.48178854
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47931211
114Apoptosis_Homo sapiens_hsa042100.47315355
115Thyroid hormone synthesis_Homo sapiens_hsa049180.46951592
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46174501
117Inositol phosphate metabolism_Homo sapiens_hsa005620.45847957
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44479824
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.44186809
120Chronic myeloid leukemia_Homo sapiens_hsa052200.43138499
121Pancreatic secretion_Homo sapiens_hsa049720.42244571
122Non-small cell lung cancer_Homo sapiens_hsa052230.42099159
123Estrogen signaling pathway_Homo sapiens_hsa049150.41246187
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.40768032
125Tyrosine metabolism_Homo sapiens_hsa003500.40701552
126Amoebiasis_Homo sapiens_hsa051460.40511125
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39383241
128Gastric acid secretion_Homo sapiens_hsa049710.38851827
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.38439720
130Glioma_Homo sapiens_hsa052140.38175396
131Prion diseases_Homo sapiens_hsa050200.38095482
132Dilated cardiomyopathy_Homo sapiens_hsa054140.35165134
133Proteoglycans in cancer_Homo sapiens_hsa052050.34956251
134B cell receptor signaling pathway_Homo sapiens_hsa046620.33607843
135Focal adhesion_Homo sapiens_hsa045100.33601073
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33476346
137Vitamin digestion and absorption_Homo sapiens_hsa049770.33394739
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.32768145
139Endometrial cancer_Homo sapiens_hsa052130.32658063
140Retinol metabolism_Homo sapiens_hsa008300.30765992
141Fructose and mannose metabolism_Homo sapiens_hsa000510.30513694
142VEGF signaling pathway_Homo sapiens_hsa043700.30385753
143Prolactin signaling pathway_Homo sapiens_hsa049170.30338934
144Galactose metabolism_Homo sapiens_hsa000520.29369927
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.28955950

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