ARFRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)6.37481896
2ribosomal small subunit assembly (GO:0000028)6.04051959
3DNA deamination (GO:0045006)5.89216998
4viral transcription (GO:0019083)5.83074123
5translational termination (GO:0006415)5.64172999
6translational elongation (GO:0006414)4.97391580
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.86365810
8ribosomal small subunit biogenesis (GO:0042274)4.83029752
9cotranslational protein targeting to membrane (GO:0006613)4.74312460
10protein targeting to ER (GO:0045047)4.71140295
11translational initiation (GO:0006413)4.61721797
12ribosomal large subunit biogenesis (GO:0042273)4.57697014
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.50569231
14GDP-mannose metabolic process (GO:0019673)4.50365515
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.45090514
16protein localization to endoplasmic reticulum (GO:0070972)4.42686249
17viral life cycle (GO:0019058)4.37218262
18cellular protein complex disassembly (GO:0043624)4.31062268
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.27469833
20mannose metabolic process (GO:0006013)4.23552675
21regulation of mitochondrial translation (GO:0070129)4.13658775
22CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.08710886
23formation of translation preinitiation complex (GO:0001731)3.85619660
24NIK/NF-kappaB signaling (GO:0038061)3.85605901
25protein complex disassembly (GO:0043241)3.82751973
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.79407690
27ribonucleoprotein complex biogenesis (GO:0022613)3.75013029
28translation (GO:0006412)3.70324133
29macromolecular complex disassembly (GO:0032984)3.66146446
30rRNA modification (GO:0000154)3.65530764
31rRNA processing (GO:0006364)3.60695337
32pseudouridine synthesis (GO:0001522)3.56940496
33positive regulation of gamma-delta T cell activation (GO:0046645)3.56468900
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.54044682
35mature B cell differentiation involved in immune response (GO:0002313)3.48407122
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47873974
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47873974
38response to peptidoglycan (GO:0032494)3.47225485
39rRNA metabolic process (GO:0016072)3.46475105
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42539791
41termination of RNA polymerase III transcription (GO:0006386)3.39472006
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.39472006
43cellular response to virus (GO:0098586)3.35606943
44mRNA catabolic process (GO:0006402)3.34526519
45regulation of type I interferon-mediated signaling pathway (GO:0060338)3.33393382
46amino sugar catabolic process (GO:0046348)3.33318033
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32515061
48cellular component biogenesis (GO:0044085)3.28853916
49response to protozoan (GO:0001562)3.24927959
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23116206
51response to type I interferon (GO:0034340)3.22360603
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18889285
53negative regulation of cell killing (GO:0031342)3.18889285
54RNA catabolic process (GO:0006401)3.17153676
55modulation by symbiont of host cellular process (GO:0044068)3.15217957
56intra-S DNA damage checkpoint (GO:0031573)3.14572813
57response to muramyl dipeptide (GO:0032495)3.14274484
58spliceosomal snRNP assembly (GO:0000387)3.12597070
59regulation of gamma-delta T cell differentiation (GO:0045586)3.12416394
60defense response to protozoan (GO:0042832)3.11903518
61protein targeting to membrane (GO:0006612)3.11344185
62antigen processing and presentation of endogenous antigen (GO:0019883)3.11249134
63type I interferon signaling pathway (GO:0060337)3.11156785
64cellular response to type I interferon (GO:0071357)3.11156785
65telomere maintenance via semi-conservative replication (GO:0032201)3.11026788
66N-acetylneuraminate metabolic process (GO:0006054)3.10327688
67rRNA methylation (GO:0031167)3.09775465
68protein complex biogenesis (GO:0070271)3.09664106
69germinal center formation (GO:0002467)3.09051046
70proteasome assembly (GO:0043248)3.08099555
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07259437
72ribosome biogenesis (GO:0042254)3.05536344
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04276540
74modulation by virus of host process (GO:0019054)3.03575896
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03480481
76DNA strand elongation involved in DNA replication (GO:0006271)3.03151418
77tRNA methylation (GO:0030488)3.02665552
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02217937
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00652764
80negative regulation of ligase activity (GO:0051352)3.00652764
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99905392
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99399367
83negative regulation of RNA splicing (GO:0033119)2.98944940
84mitochondrial respiratory chain complex assembly (GO:0033108)2.98563904
85mature B cell differentiation (GO:0002335)2.98540694
86cellular response to exogenous dsRNA (GO:0071360)2.97867794
87negative regulation of tumor necrosis factor production (GO:0032720)2.95543940
88cytochrome complex assembly (GO:0017004)2.95434311
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92223505
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92084013
91pyrimidine nucleoside salvage (GO:0043097)2.91657710
92pyrimidine-containing compound salvage (GO:0008655)2.91657710
93DNA strand elongation (GO:0022616)2.89726964
94nucleobase biosynthetic process (GO:0046112)2.89660969
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89124393
96UV protection (GO:0009650)2.88487584
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88295114
98metallo-sulfur cluster assembly (GO:0031163)2.88030397
99iron-sulfur cluster assembly (GO:0016226)2.88030397
100ATP synthesis coupled proton transport (GO:0015986)2.87843398
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87843398
102negative regulation of erythrocyte differentiation (GO:0045647)2.87404226
103phosphatidylglycerol biosynthetic process (GO:0006655)2.86905393
104myeloid dendritic cell differentiation (GO:0043011)2.86269053
105negative regulation of viral release from host cell (GO:1902187)2.84272892
106activation of MAPKKK activity (GO:0000185)2.83880088
107positive regulation of Cdc42 GTPase activity (GO:0043089)2.83836272
108negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.83217586
109negative regulation of interleukin-12 production (GO:0032695)2.82474991
110mitochondrial respiratory chain complex I assembly (GO:0032981)2.82068418
111NADH dehydrogenase complex assembly (GO:0010257)2.82068418
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82068418
113ncRNA processing (GO:0034470)2.81013896
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80848382
115macrophage activation involved in immune response (GO:0002281)2.79764367
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78828112
117positive regulation of histone deacetylation (GO:0031065)2.77578848
118ncRNA 3-end processing (GO:0043628)2.77190082
119negative regulation of innate immune response (GO:0045824)2.76901206
120protein targeting to mitochondrion (GO:0006626)2.76304291
121regulation of cellular amino acid metabolic process (GO:0006521)2.75972224
122positive regulation of protein kinase C signaling (GO:0090037)2.75736649
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75139270
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75139270
125autophagic vacuole fusion (GO:0000046)2.75012828
126telomere maintenance via recombination (GO:0000722)2.74985958
127cellular response to interferon-beta (GO:0035458)2.72609805
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71966687
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71966687
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71966687
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70730334
132purine nucleobase biosynthetic process (GO:0009113)2.70173977
133DNA replication checkpoint (GO:0000076)2.69652280
134RNA methylation (GO:0001510)2.69337661
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.68974755
136regulation of vitamin D biosynthetic process (GO:0060556)2.68188002
137regulation of gamma-delta T cell activation (GO:0046643)2.68172227
138adenosine receptor signaling pathway (GO:0001973)2.67501239
139purine deoxyribonucleotide catabolic process (GO:0009155)2.66928918
140positive thymic T cell selection (GO:0045059)2.66846001
141peptidyl-histidine modification (GO:0018202)2.65964533
142positive regulation of natural killer cell differentiation (GO:0032825)2.65742360
143positive regulation of defense response to virus by host (GO:0002230)2.65482693
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65419834
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.65419834
146histone mRNA metabolic process (GO:0008334)2.64886815
147oxidative phosphorylation (GO:0006119)2.64689981
148respiratory chain complex IV assembly (GO:0008535)2.64262647
149low-density lipoprotein particle clearance (GO:0034383)2.63785350
150positive regulation of B cell differentiation (GO:0045579)2.63368364
151positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63229614
152regulation of interferon-beta biosynthetic process (GO:0045357)2.60641539
153regulation of chemokine biosynthetic process (GO:0045073)2.60314097
154negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59759731
155T cell lineage commitment (GO:0002360)2.56661719
156nucleotide salvage (GO:0043173)2.55689791
157pinocytosis (GO:0006907)2.55432398
158immunoglobulin mediated immune response (GO:0016064)2.54635127
159positive regulation of lymphocyte apoptotic process (GO:0070230)2.54486260
160positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54482483
161regulation of necrotic cell death (GO:0010939)2.53671200
162interferon-gamma-mediated signaling pathway (GO:0060333)2.52577964
163regulation of T-helper 1 cell differentiation (GO:0045625)2.52348062
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52023516
165regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.50424622
166glycosphingolipid catabolic process (GO:0046479)2.49592705
167regulation of tumor necrosis factor production (GO:0032680)2.48613700
168myeloid dendritic cell activation (GO:0001773)2.48356799
169negative regulation of cytokine production involved in immune response (GO:0002719)2.48221063
170endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.47369505
171regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46504195
172positive regulation of protein deacetylation (GO:0090312)2.45963306
173antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45879240
174regulation of viral release from host cell (GO:1902186)2.45618653
175regulation of defense response to virus by host (GO:0050691)2.43860630
176regulation of necroptotic process (GO:0060544)2.42786255
177positive regulation of chemokine biosynthetic process (GO:0045080)2.42203333
178modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41509396
179positive regulation by organism of defense response of other organism involved in symbiotic interact2.41509396
180modulation by symbiont of host immune response (GO:0052553)2.41509396
181positive regulation by symbiont of host defense response (GO:0052509)2.41509396
182modulation by symbiont of host defense response (GO:0052031)2.41509396
183modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41509396
184regulation of hydrogen peroxide metabolic process (GO:0010310)2.40931848
185negative regulation of myeloid cell apoptotic process (GO:0033033)2.37087475
186regulation of interferon-alpha production (GO:0032647)2.36821993
187barbed-end actin filament capping (GO:0051016)2.34283128
188protein localization to endosome (GO:0036010)2.33477440
189positive regulation of antigen processing and presentation (GO:0002579)2.32937938
190purinergic receptor signaling pathway (GO:0035587)2.32791387
191regulation of antigen processing and presentation (GO:0002577)2.32467155
192regulation of mast cell degranulation (GO:0043304)2.32308950
193negative regulation of DNA-templated transcription, elongation (GO:0032785)2.31989047
194negative regulation of cell size (GO:0045792)2.31292307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.23649373
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.15974644
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.85494567
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.56112541
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40043599
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.20237672
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19737070
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14552394
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.07080885
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03812176
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92933438
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92845892
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84072831
14LXR_22292898_ChIP-Seq_THP-1_Human2.80568331
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.79990180
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70473905
17VDR_23849224_ChIP-Seq_CD4+_Human2.65185812
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54489038
19XRN2_22483619_ChIP-Seq_HELA_Human2.54350104
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52798079
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46681957
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33282227
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.32455473
24CIITA_25753668_ChIP-Seq_RAJI_Human2.28932009
25FOXP3_21729870_ChIP-Seq_TREG_Human2.25838318
26MYC_22102868_ChIP-Seq_BL_Human2.25729655
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25189509
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22995572
29KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17827062
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17621583
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14009580
32GABP_19822575_ChIP-Seq_HepG2_Human2.08394476
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06329186
34E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06043214
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04677243
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02813417
37P68_20966046_ChIP-Seq_HELA_Human2.01566677
38* DCP1A_22483619_ChIP-Seq_HELA_Human1.98517460
39RACK7_27058665_Chip-Seq_MCF-7_Human1.97325986
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.96942412
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.96828763
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96291289
43BCL6_27268052_Chip-Seq_Bcells_Human1.95981236
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94719842
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94330729
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94221132
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92933132
48VDR_21846776_ChIP-Seq_THP-1_Human1.89648170
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87905481
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.87833023
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85619936
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84714020
53BCOR_27268052_Chip-Seq_Bcells_Human1.84657430
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.84647984
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82862637
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82597723
57TTF2_22483619_ChIP-Seq_HELA_Human1.79635704
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79234326
59KDM2B_26808549_Chip-Seq_DND41_Human1.75777385
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70179358
61TCF7_22412390_ChIP-Seq_EML_Mouse1.67578236
62SMC4_20622854_ChIP-Seq_HELA_Human1.66529629
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.66376612
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65374277
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.62204076
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58612436
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.56967893
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56702972
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56220945
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55229927
71* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54984412
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54597623
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54265827
74SPI1_23547873_ChIP-Seq_NB4_Human1.53175101
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52146006
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51756436
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.49562715
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45095041
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43106851
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.41622305
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41527387
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41419723
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41346901
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39584817
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.39219401
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.39150131
87KDM5A_27292631_Chip-Seq_BREAST_Human1.38515338
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.38471711
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37982888
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36775452
91E2F1_20622854_ChIP-Seq_HELA_Human1.36377682
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35059659
93ELK1_19687146_ChIP-ChIP_HELA_Human1.33947338
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33733060
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33638029
96PHF8_20622854_ChIP-Seq_HELA_Human1.33109545
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32997740
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32417602
99MAF_26560356_Chip-Seq_TH1_Human1.31978299
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.31941067
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31635133
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30467597
103ZNF263_19887448_ChIP-Seq_K562_Human1.30326970
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30168144
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.30008225
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.29858680
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29609252
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29310371
109NCOR1_26117541_ChIP-Seq_K562_Human1.28960962
110MYB_26560356_Chip-Seq_TH2_Human1.28935727
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.27913585
112UTX_26944678_Chip-Seq_JUKART_Human1.27181412
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26182271
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24483882
115CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24183508
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23259403
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.23006258
118TP53_22127205_ChIP-Seq_IMR90_Human1.22805462
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22003647
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21834746
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21703117
122SA1_27219007_Chip-Seq_Bcells_Human1.19511593
123* CTCF_21964334_Chip-Seq_Bcells_Human1.18854357
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18235040
125CREB1_26743006_Chip-Seq_LNCaP_Human1.18049444
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16327875
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16185566
128MAF_26560356_Chip-Seq_TH2_Human1.15437029
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14606267
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13916154
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13710335
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13699349
133PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13561888
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13408075
135MYB_26560356_Chip-Seq_TH1_Human1.13158258
136ATF3_27146783_Chip-Seq_COLON_Human1.13121262
137* SPI1_23127762_ChIP-Seq_K562_Human1.12803433
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12676557
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11968083
140TP63_22573176_ChIP-Seq_HFKS_Human1.11908992
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11792715
142RARA_24833708_ChIP-Seq_LIVER_Mouse1.11485720
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11332214
144CTCF_20526341_ChIP-Seq_ESCs_Human1.10013196
145KDM2B_26808549_Chip-Seq_K562_Human1.09665549
146* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09384453
147ELK1_22589737_ChIP-Seq_MCF10A_Human1.08937298
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07694162
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07348904
150* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07325823
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06551209
152MYC_18940864_ChIP-ChIP_HL60_Human1.06496619
153STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06438770
154ETS1_21867929_ChIP-Seq_TH2_Mouse1.06254068
155CTCF_27219007_Chip-Seq_Bcells_Human1.05584031
156NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05461420
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05258146
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05248330
159VDR_24763502_ChIP-Seq_THP-1_Human1.04523974
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03249878
161CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02642104
162GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01933497
163TFEB_21752829_ChIP-Seq_HELA_Human0.99993232
164SCL_19346495_ChIP-Seq_HPC-7_Human0.97487038
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97481905
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96132713
167YY1_22570637_ChIP-Seq_MALME-3M_Human0.94880655
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93991910
169RUNX1_22412390_ChIP-Seq_EML_Mouse0.93090775
170E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92634917
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91816995
172PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90173491
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90066126
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89612569

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.93152118
2MP0003763_abnormal_thymus_physiology3.57304492
3MP0003693_abnormal_embryo_hatching3.41372273
4MP0005671_abnormal_response_to3.40050223
5MP0002396_abnormal_hematopoietic_system3.37705450
6MP0005451_abnormal_body_composition3.07378998
7MP0000685_abnormal_immune_system2.98193443
8MP0009840_abnormal_foam_cell2.92995264
9MP0008058_abnormal_DNA_repair2.62183961
10MP0001835_abnormal_antigen_presentation2.47179367
11MP0002398_abnormal_bone_marrow2.43604767
12MP0009333_abnormal_splenocyte_physiolog2.41894850
13MP0001800_abnormal_humoral_immune2.39685827
14MP0004957_abnormal_blastocyst_morpholog2.36058512
15MP0008007_abnormal_cellular_replicative2.32279864
16MP0010094_abnormal_chromosome_stability2.27953119
17MP0003077_abnormal_cell_cycle2.23078614
18MP0006082_CNS_inflammation2.21420704
19MP0002420_abnormal_adaptive_immunity2.12983083
20MP0002132_abnormal_respiratory_system2.12517976
21MP0009278_abnormal_bone_marrow2.12510200
22MP0003172_abnormal_lysosome_physiology2.08726806
23MP0001819_abnormal_immune_cell2.08546854
24MP0005083_abnormal_biliary_tract2.07182225
25MP0001853_heart_inflammation2.06678876
26MP0000703_abnormal_thymus_morphology2.05388706
27MP0005000_abnormal_immune_tolerance2.04866230
28MP0003436_decreased_susceptibility_to2.02671214
29MP0006036_abnormal_mitochondrial_physio2.01961424
30MP0002723_abnormal_immune_serum2.00820129
31MP0003111_abnormal_nucleus_morphology1.99485265
32MP0003646_muscle_fatigue1.99391029
33MP0000716_abnormal_immune_system1.97376323
34MP0002722_abnormal_immune_system1.97349363
35MP0002452_abnormal_antigen_presenting1.95235660
36MP0009785_altered_susceptibility_to1.95191418
37MP0000689_abnormal_spleen_morphology1.89618582
38MP0003453_abnormal_keratinocyte_physiol1.87025709
39MP0004808_abnormal_hematopoietic_stem1.85977150
40MP0005174_abnormal_tail_pigmentation1.84943806
41MP0005025_abnormal_response_to1.84188445
42MP0002429_abnormal_blood_cell1.83447415
43MP0005387_immune_system_phenotype1.79223758
44MP0001790_abnormal_immune_system1.79223758
45MP0003806_abnormal_nucleotide_metabolis1.78846303
46MP0005075_abnormal_melanosome_morpholog1.78673920
47MP0008057_abnormal_DNA_replication1.72279474
48MP0003866_abnormal_defecation1.64441532
49MP0000490_abnormal_crypts_of1.62187184
50MP0009764_decreased_sensitivity_to1.62166676
51MP0006035_abnormal_mitochondrial_morpho1.58566906
52MP0004084_abnormal_cardiac_muscle1.51982984
53MP0003724_increased_susceptibility_to1.50951945
54MP0003191_abnormal_cellular_cholesterol1.40099100
55MP0002405_respiratory_system_inflammati1.37711425
56MP0002019_abnormal_tumor_incidence1.36460670
57MP0002148_abnormal_hypersensitivity_rea1.36283971
58MP0001873_stomach_inflammation1.35586257
59MP0005310_abnormal_salivary_gland1.34285634
60MP0009379_abnormal_foot_pigmentation1.34008290
61MP0000003_abnormal_adipose_tissue1.29851115
62MP0000858_altered_metastatic_potential1.29638416
63MP0003705_abnormal_hypodermis_morpholog1.29607273
64MP0005167_abnormal_blood-brain_barrier1.28437631
65MP0000015_abnormal_ear_pigmentation1.28180223
66MP0003329_amyloid_beta_deposits1.27656962
67MP0000604_amyloidosis1.26829669
68MP0002166_altered_tumor_susceptibility1.26498332
69MP0005076_abnormal_cell_differentiation1.24063948
70MP0003075_altered_response_to1.23539141
71MP0000343_altered_response_to1.23176657
72MP0000678_abnormal_parathyroid_gland1.22117368
73MP0002419_abnormal_innate_immunity1.19401649
74MP0002837_dystrophic_cardiac_calcinosis1.18063855
75MP0004043_abnormal_pH_regulation1.18057767
76MP0010155_abnormal_intestine_physiology1.17821968
77MP0000750_abnormal_muscle_regeneration1.17186991
78MP0000313_abnormal_cell_death1.17136685
79MP0005360_urolithiasis1.14752068
80MP0008932_abnormal_embryonic_tissue1.13768540
81MP0001545_abnormal_hematopoietic_system1.13342207
82MP0005397_hematopoietic_system_phenotyp1.13342207
83MP0002163_abnormal_gland_morphology1.13193804
84MP0004215_abnormal_myocardial_fiber1.12907427
85MP0002095_abnormal_skin_pigmentation1.11306706
86MP0001849_ear_inflammation1.10566596
87MP0002332_abnormal_exercise_endurance1.10326285
88MP0003300_gastrointestinal_ulcer1.10193100
89MP0002638_abnormal_pupillary_reflex1.10030679
90MP0004036_abnormal_muscle_relaxation1.09834031
91MP0000465_gastrointestinal_hemorrhage1.08125972
92MP0003303_peritoneal_inflammation1.07440772
93MP0005375_adipose_tissue_phenotype1.04703807
94MP0001845_abnormal_inflammatory_respons1.04166651
95MP0006292_abnormal_olfactory_placode1.03824774
96MP0002998_abnormal_bone_remodeling1.02586427
97MP0005464_abnormal_platelet_physiology1.02419207
98MP0002254_reproductive_system_inflammat1.02209555
99MP0000749_muscle_degeneration1.01849859
100MP0003786_premature_aging1.00275599
101MP0000358_abnormal_cell_content/0.99284355
102MP0002006_tumorigenesis0.99023701
103MP0004147_increased_porphyrin_level0.98769772
104MP0005166_decreased_susceptibility_to0.97712314
105MP0000013_abnormal_adipose_tissue0.96624090
106MP0005379_endocrine/exocrine_gland_phen0.96307191
107MP0005584_abnormal_enzyme/coenzyme_acti0.96169259
108MP0000350_abnormal_cell_proliferation0.95996765
109MP0005365_abnormal_bile_salt0.95112776
110MP0004130_abnormal_muscle_cell0.91668148
111MP0002933_joint_inflammation0.91424950
112MP0004858_abnormal_nervous_system0.89949608
113MP0004185_abnormal_adipocyte_glucose0.87668525
114MP0003656_abnormal_erythrocyte_physiolo0.87666617
115MP0008469_abnormal_protein_level0.86628307
116MP0005666_abnormal_adipose_tissue0.86020781
117MP0000751_myopathy0.85720778
118MP0004381_abnormal_hair_follicle0.84803464
119MP0005023_abnormal_wound_healing0.84413739
120MP0003183_abnormal_peptide_metabolism0.84144361
121MP0000747_muscle_weakness0.84048817
122MP0003279_aneurysm0.83780963
123MP0008874_decreased_physiological_sensi0.83514305
124MP0003091_abnormal_cell_migration0.81952954
125MP0001958_emphysema0.81573221
126MP0002139_abnormal_hepatobiliary_system0.80148132
127MP0001986_abnormal_taste_sensitivity0.79184879
128* MP0002080_prenatal_lethality0.78252095
129MP0005319_abnormal_enzyme/_coenzyme0.78114516
130MP0005390_skeleton_phenotype0.77743518
131MP0001730_embryonic_growth_arrest0.74547488
132MP0000609_abnormal_liver_physiology0.74464588
133MP0004510_myositis0.73998918
134MP0002877_abnormal_melanocyte_morpholog0.72880731
135MP0002089_abnormal_postnatal_growth/wei0.71452601
136MP0005330_cardiomyopathy0.71230198
137MP0003567_abnormal_fetal_cardiomyocyte0.70339292
138MP0003221_abnormal_cardiomyocyte_apopto0.67845112
139MP0002693_abnormal_pancreas_physiology0.66846863
140MP0002277_abnormal_respiratory_mucosa0.66699071
141MP0003123_paternal_imprinting0.66482603
142MP0001697_abnormal_embryo_size0.65531851
143MP0004947_skin_inflammation0.65046410
144MP0008260_abnormal_autophagy0.62685259
145MP0003315_abnormal_perineum_morphology0.61441320
146MP0005670_abnormal_white_adipose0.61351271
147MP0002106_abnormal_muscle_physiology0.60772258
148MP0001533_abnormal_skeleton_physiology0.59775331
149MP0001663_abnormal_digestive_system0.57868393
150MP0003828_pulmonary_edema0.57318041

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.05963858
2Abnormal number of erythroid precursors (HP:0012131)4.93362759
3Abnormality of glycolipid metabolism (HP:0010969)4.84040267
4Abnormality of liposaccharide metabolism (HP:0010968)4.84040267
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.84040267
6Aplastic anemia (HP:0001915)4.37175313
7Elevated erythrocyte sedimentation rate (HP:0003565)4.22418800
8Hepatocellular necrosis (HP:0001404)4.18902914
9Reticulocytopenia (HP:0001896)3.91351982
10Mitochondrial inheritance (HP:0001427)3.88558550
11Acute necrotizing encephalopathy (HP:0006965)3.86450922
12Dysostosis multiplex (HP:0000943)3.84645294
13Hepatic necrosis (HP:0002605)3.80936698
14Abnormal mitochondria in muscle tissue (HP:0008316)3.71460416
15Increased cerebral lipofuscin (HP:0011813)3.68559270
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.67626980
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.67626980
18IgM deficiency (HP:0002850)3.65769104
19Increased CSF lactate (HP:0002490)3.64233491
20Macrocytic anemia (HP:0001972)3.57777171
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.47421093
22Thrombocytosis (HP:0001894)3.46520788
23Pallor (HP:0000980)3.42466395
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.41792201
25Abnormality of polysaccharide metabolism (HP:0011012)3.41792201
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.41792201
27Abnormality of alanine metabolism (HP:0010916)3.17588362
28Hyperalaninemia (HP:0003348)3.17588362
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17588362
30Acute encephalopathy (HP:0006846)3.13521990
31Increased serum lactate (HP:0002151)3.12878211
323-Methylglutaconic aciduria (HP:0003535)3.11390131
33Hemorrhage of the eye (HP:0011885)3.10498318
34Increased serum ferritin (HP:0003281)3.08235003
35Mucopolysacchariduria (HP:0008155)3.05997987
36Urinary glycosaminoglycan excretion (HP:0003541)3.05997987
37Abnormality of B cell number (HP:0010975)3.03954515
38B lymphocytopenia (HP:0010976)3.03954515
39Abnormality of macrophages (HP:0004311)3.01086595
40Recurrent bronchitis (HP:0002837)2.97522141
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.95114300
42Lactic acidosis (HP:0003128)2.94476704
43Thin bony cortex (HP:0002753)2.92214164
44Progressive macrocephaly (HP:0004481)2.90329659
45Type I transferrin isoform profile (HP:0003642)2.90066384
46IgG deficiency (HP:0004315)2.87208785
47Colitis (HP:0002583)2.86347612
48Oral leukoplakia (HP:0002745)2.85444482
49Progressive muscle weakness (HP:0003323)2.83952112
50Loss of speech (HP:0002371)2.82654717
51Respiratory difficulties (HP:0002880)2.82537140
52Microvesicular hepatic steatosis (HP:0001414)2.81529972
53Increased hepatocellular lipid droplets (HP:0006565)2.78411918
54Panhypogammaglobulinemia (HP:0003139)2.73881468
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71313814
56Eczematoid dermatitis (HP:0000976)2.68591542
57Colon cancer (HP:0003003)2.68013452
58Systemic lupus erythematosus (HP:0002725)2.64796188
59Lipid accumulation in hepatocytes (HP:0006561)2.64511364
60Increased intramyocellular lipid droplets (HP:0012240)2.61700910
61Pustule (HP:0200039)2.59806852
62Chronic otitis media (HP:0000389)2.59253679
63Pancytopenia (HP:0001876)2.58150260
64Exertional dyspnea (HP:0002875)2.58143285
65Recurrent bacterial skin infections (HP:0005406)2.57571998
66Recurrent abscess formation (HP:0002722)2.53206743
67Abnormality of T cells (HP:0002843)2.53126992
68Respiratory failure (HP:0002878)2.51034190
69Orchitis (HP:0100796)2.48667928
70Ragged-red muscle fibers (HP:0003200)2.47632663
71Agammaglobulinemia (HP:0004432)2.46444025
72Exercise intolerance (HP:0003546)2.46418178
73Multiple enchondromatosis (HP:0005701)2.45350868
74Increased muscle lipid content (HP:0009058)2.45340043
75Abnormal protein N-linked glycosylation (HP:0012347)2.43534418
76Abnormal protein glycosylation (HP:0012346)2.43534418
77Abnormal glycosylation (HP:0012345)2.43534418
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43534418
79Distal upper limb amyotrophy (HP:0007149)2.41571848
80Upper limb amyotrophy (HP:0009129)2.41571848
81Malnutrition (HP:0004395)2.41163108
82Purpura (HP:0000979)2.40468787
83Abnormality of T cell physiology (HP:0011840)2.39342064
84Emotional lability (HP:0000712)2.39235289
85Vacuolated lymphocytes (HP:0001922)2.39079739
86Prolonged neonatal jaundice (HP:0006579)2.38186554
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.37084464
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36368283
89Gastrointestinal stroma tumor (HP:0100723)2.35392312
90Reduced antithrombin III activity (HP:0001976)2.33676772
91J-shaped sella turcica (HP:0002680)2.31522699
92Cerebral hypomyelination (HP:0006808)2.29490964
93Interstitial pulmonary disease (HP:0006530)2.28382318
94Lymphoma (HP:0002665)2.27956737
95Testicular atrophy (HP:0000029)2.27282169
96Abnormality of iron homeostasis (HP:0011031)2.23623238
97Muscle fiber atrophy (HP:0100295)2.22301260
98Axonal loss (HP:0003447)2.21226189
99Achilles tendon contracture (HP:0001771)2.20515205
100Myositis (HP:0100614)2.19735971
101Rough bone trabeculation (HP:0100670)2.19610792
102Vertebral compression fractures (HP:0002953)2.19091813
103Distal lower limb amyotrophy (HP:0008944)2.18395702
104Nasal polyposis (HP:0100582)2.18066693
105Hypertriglyceridemia (HP:0002155)2.17832284
106Hypertensive crisis (HP:0100735)2.13725109
107Inflammation of the large intestine (HP:0002037)2.13717775
108Lymphopenia (HP:0001888)2.13507683
109Nuclear cataract (HP:0100018)2.12599682
110T lymphocytopenia (HP:0005403)2.12476979
111Cellulitis (HP:0100658)2.12037645
112Poikiloderma (HP:0001029)2.11458800
113Abnormality of the nasal mucosa (HP:0000433)2.10073496
114Stridor (HP:0010307)2.09979519
115Abnormality of cells of the lymphoid lineage (HP:0012140)2.09776431
116Gastrointestinal infarctions (HP:0005244)2.09587275
117Severe visual impairment (HP:0001141)2.09321901
118Autoimmune thrombocytopenia (HP:0001973)2.08272799
119Obstructive lung disease (HP:0006536)2.08259236
120Chronic obstructive pulmonary disease (HP:0006510)2.08259236
121Abnormality of glycolysis (HP:0004366)2.07243970
122Increased serum pyruvate (HP:0003542)2.07243970
123Mesangial abnormality (HP:0001966)2.06414792
124Retrobulbar optic neuritis (HP:0100654)2.05366590
125Optic neuritis (HP:0100653)2.05366590
126Joint stiffness (HP:0001387)2.05338530
127Recurrent viral infections (HP:0004429)2.04037866
128Squamous cell carcinoma (HP:0002860)2.03458793
129Increased connective tissue (HP:0009025)2.03414566
130Difficulty climbing stairs (HP:0003551)2.02106521
131Abnormal delayed hypersensitivity skin test (HP:0002963)2.01080385
132Myopathic facies (HP:0002058)2.00778000
133Neuronal loss in central nervous system (HP:0002529)2.00268878
134CNS demyelination (HP:0007305)1.99861023
135Abnormality of T cell number (HP:0011839)1.96264331
136Stomatitis (HP:0010280)1.96249129
137Amaurosis fugax (HP:0100576)1.95287048
138Type 2 muscle fiber atrophy (HP:0003554)1.95156032
139Abnormality of the Achilles tendon (HP:0005109)1.95086900
140Severe combined immunodeficiency (HP:0004430)1.94828877
141Chronic mucocutaneous candidiasis (HP:0002728)1.94195484
142Recurrent cutaneous fungal infections (HP:0011370)1.94195484
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93950587
144Premature graying of hair (HP:0002216)1.92304587
145Cerebral edema (HP:0002181)1.92237272
146Emphysema (HP:0002097)1.91905572
147Gastrointestinal dysmotility (HP:0002579)1.91106008
148Neutropenia (HP:0001875)1.90493716
149Ulnar bowing (HP:0003031)1.90128140
150Meningitis (HP:0001287)1.88252482
151Progressive neurologic deterioration (HP:0002344)1.87243594
152Recurrent skin infections (HP:0001581)1.86959933
153Prolonged bleeding time (HP:0003010)1.86938992
154Hypoplasia of the thymus (HP:0000778)1.86218152
155Recurrent fungal infections (HP:0002841)1.84337203
156Asymmetric septal hypertrophy (HP:0001670)1.82892220
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.82528772
158Renal Fanconi syndrome (HP:0001994)1.82423021
159Amyloidosis (HP:0011034)1.82142071
160Neurofibrillary tangles (HP:0002185)1.81750842
161Mediastinal lymphadenopathy (HP:0100721)1.80502166
162Optic disc pallor (HP:0000543)1.79726662
163Abnormality of transition element cation homeostasis (HP:0011030)1.79201760
164Hyperacusis (HP:0010780)1.79139904
165Microretrognathia (HP:0000308)1.78268824
166Petechiae (HP:0000967)1.78112194
167Birth length less than 3rd percentile (HP:0003561)1.77347531
168Abnormality of eosinophils (HP:0001879)1.77249517
169Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75701953
170Gastrointestinal inflammation (HP:0004386)1.75236608
171Cheilitis (HP:0100825)1.75117144
172Increased IgE level (HP:0003212)1.75078667
173Epistaxis (HP:0000421)1.74610002
174Broad face (HP:0000283)1.74397654
175IgA deficiency (HP:0002720)1.72644907
176Opisthotonus (HP:0002179)1.72474787
177Encephalitis (HP:0002383)1.72178472
178Progressive microcephaly (HP:0000253)1.72083559
179Flat occiput (HP:0005469)1.71346095
180Visual hallucinations (HP:0002367)1.69818542
181Hepatosplenomegaly (HP:0001433)1.69362015
182Supranuclear gaze palsy (HP:0000605)1.67759980
183Distal lower limb muscle weakness (HP:0009053)1.67421709
184Thoracic kyphosis (HP:0002942)1.67406828
185Akinesia (HP:0002304)1.66437818
186Xanthomatosis (HP:0000991)1.65295387
187Cerebral inclusion bodies (HP:0100314)1.64477958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.77613961
2TLK13.53396487
3TRIB33.52356815
4NME23.49527719
5MAP4K13.10963759
6BUB13.05722618
7STK162.89103751
8DYRK32.76838596
9WEE12.58231814
10ACVR1B2.54179646
11PIM22.15522363
12KDR2.14445351
13TAOK21.97057608
14TESK21.95695683
15SIK11.95219248
16BCKDK1.94714123
17MAP3K101.92249387
18EPHA21.90302607
19ZAP701.85790153
20PRPF4B1.83017129
21SMG11.71435394
22ICK1.70212955
23TXK1.64325843
24MST1R1.63330691
25NME11.61359213
26SRPK11.57953832
27RPS6KA41.51757778
28NLK1.51306972
29MAP3K31.49593243
30TSSK61.46050779
31MAP2K61.40064088
32BTK1.39808763
33SIK21.39442963
34IRAK31.36265776
35LRRK21.35500294
36JAK31.34232472
37MAPK111.33936620
38IRAK41.31566500
39VRK11.31366466
40NEK21.31130043
41TBK11.30851087
42CCNB11.29701824
43CDC42BPA1.28751557
44TYK21.28224099
45PRKD21.27953351
46EIF2AK11.27910035
47TGFBR11.24438924
48TEC1.20431624
49KIT1.15850536
50MAP3K141.13454444
51SYK1.12621565
52ERN11.12402807
53RIPK41.09851907
54BRSK21.08408782
55EPHB11.06052291
56TAOK11.05248426
57ABL21.00445653
58TESK11.00245694
59BMX0.99881906
60TNK20.99542605
61CDC70.98345803
62GRK60.97592034
63MKNK20.96885813
64PASK0.96865785
65FLT30.96645267
66PDK30.96167434
67PDK40.96167434
68PDPK10.93459324
69MAP2K30.93256121
70MUSK0.93160000
71IKBKE0.91840133
72IRAK10.90717762
73RIPK10.90153715
74MAP3K10.88830527
75MAP3K110.88829875
76MST40.88745567
77MAPKAPK30.88237269
78SIK30.87141246
79ILK0.85659216
80MARK20.85057322
81LCK0.82471044
82MKNK10.80671608
83HIPK20.79633842
84BRSK10.79608240
85IKBKB0.79544185
86STK100.76827040
87PTK60.76421164
88CSK0.72380328
89CDK70.71746373
90ITK0.71254673
91SCYL20.70272637
92FES0.70012071
93PLK40.69306939
94DDR20.68549328
95PKN20.68228816
96MATK0.68060424
97CSF1R0.67700554
98BRAF0.67549331
99RPS6KB20.63320236
100CDK40.63314137
101PLK10.62858051
102ARAF0.62194609
103WNK40.59248033
104EIF2AK30.59243553
105AURKB0.59212236
106DYRK20.58942229
107MYLK0.57242326
108DAPK10.56628371
109MAP2K20.56339015
110RPS6KC10.54665134
111RPS6KL10.54665134
112RPS6KA20.54534503
113CAMKK10.54246450
114LYN0.54054322
115PIM10.52959964
116HCK0.52624875
117DAPK20.52467777
118ATR0.52332132
119MTOR0.52270883
120RPS6KA60.52183486
121IRAK20.51197556
122CSNK2A20.49094556
123PDK10.47736548
124MET0.47557854
125TGFBR20.46393427
126TTN0.46335855
127RAF10.45127889
128FGR0.43626414
129CSNK2A10.42408140
130MAP3K70.39832471
131TNIK0.39603080
132FGFR40.39488737
133PRKD10.38946254
134MAPKAPK20.38360077
135MAP3K60.38172002
136PTK20.37962229
137STK380.37507791
138MAP3K80.36706223
139CHUK0.36681112
140GRK70.36669582
141PTK2B0.36429918
142EEF2K0.35923717
143MAP3K130.35185056
144MAPK120.35061612
145MAP3K120.34736562
146PRKCI0.33582142
147LMTK20.33146974
148OBSCN0.32321665
149CAMKK20.31527471
150BLK0.31399519
151PAK40.31385054
152NEK10.31274312
153BRD40.30472285
154CAMK2G0.30156094
155DAPK30.29478394

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.31400312
2Other glycan degradation_Homo sapiens_hsa005114.03246904
3Proteasome_Homo sapiens_hsa030503.75929015
4RNA polymerase_Homo sapiens_hsa030203.38020795
5DNA replication_Homo sapiens_hsa030303.35892649
6Spliceosome_Homo sapiens_hsa030402.99993761
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.94976695
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91186689
9Mismatch repair_Homo sapiens_hsa034302.86079968
10Primary immunodeficiency_Homo sapiens_hsa053402.54471423
11Homologous recombination_Homo sapiens_hsa034402.46576047
12Base excision repair_Homo sapiens_hsa034102.42936447
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.42209844
14Pyrimidine metabolism_Homo sapiens_hsa002402.41957925
15Lysosome_Homo sapiens_hsa041422.31073065
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20714374
17Parkinsons disease_Homo sapiens_hsa050122.19865447
18Oxidative phosphorylation_Homo sapiens_hsa001902.10807235
19RNA transport_Homo sapiens_hsa030132.07218177
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.95777535
21Nucleotide excision repair_Homo sapiens_hsa034201.90499841
22TNF signaling pathway_Homo sapiens_hsa046681.76534971
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73819568
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71228282
25Sulfur relay system_Homo sapiens_hsa041221.67304500
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65583580
27RNA degradation_Homo sapiens_hsa030181.64570715
28Staphylococcus aureus infection_Homo sapiens_hsa051501.50531201
29Huntingtons disease_Homo sapiens_hsa050161.44799777
30Toxoplasmosis_Homo sapiens_hsa051451.43492219
31Asthma_Homo sapiens_hsa053101.42117332
32Autoimmune thyroid disease_Homo sapiens_hsa053201.39998954
33Bladder cancer_Homo sapiens_hsa052191.39888397
34Pertussis_Homo sapiens_hsa051331.37750211
35Basal transcription factors_Homo sapiens_hsa030221.37517587
36Antigen processing and presentation_Homo sapiens_hsa046121.36801196
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35425546
38Herpes simplex infection_Homo sapiens_hsa051681.35378749
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34989495
40Purine metabolism_Homo sapiens_hsa002301.33805133
41Alzheimers disease_Homo sapiens_hsa050101.32910636
42Protein export_Homo sapiens_hsa030601.32755591
43VEGF signaling pathway_Homo sapiens_hsa043701.29814479
44Hepatitis C_Homo sapiens_hsa051601.23616379
45Epstein-Barr virus infection_Homo sapiens_hsa051691.22512358
46Galactose metabolism_Homo sapiens_hsa000521.20251781
47Fanconi anemia pathway_Homo sapiens_hsa034601.16279925
48Rheumatoid arthritis_Homo sapiens_hsa053231.16231989
49T cell receptor signaling pathway_Homo sapiens_hsa046601.12423349
50Cell cycle_Homo sapiens_hsa041101.12404481
51One carbon pool by folate_Homo sapiens_hsa006701.11497726
52Caffeine metabolism_Homo sapiens_hsa002321.05155231
53Measles_Homo sapiens_hsa051621.05029050
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.04592527
55Non-homologous end-joining_Homo sapiens_hsa034501.02052368
56Notch signaling pathway_Homo sapiens_hsa043301.01920566
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99627956
58Legionellosis_Homo sapiens_hsa051340.94858948
59B cell receptor signaling pathway_Homo sapiens_hsa046620.93293395
60Sphingolipid metabolism_Homo sapiens_hsa006000.93060390
61Systemic lupus erythematosus_Homo sapiens_hsa053220.93046901
62Hematopoietic cell lineage_Homo sapiens_hsa046400.91909257
63Folate biosynthesis_Homo sapiens_hsa007900.91761867
64Pentose phosphate pathway_Homo sapiens_hsa000300.91318111
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89116053
66Cardiac muscle contraction_Homo sapiens_hsa042600.88093095
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87750907
68Malaria_Homo sapiens_hsa051440.85371323
69Insulin resistance_Homo sapiens_hsa049310.82931577
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82674542
71Endocytosis_Homo sapiens_hsa041440.81339289
72Allograft rejection_Homo sapiens_hsa053300.81259878
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.80271001
74Chronic myeloid leukemia_Homo sapiens_hsa052200.79842459
75mRNA surveillance pathway_Homo sapiens_hsa030150.76804793
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76658913
77p53 signaling pathway_Homo sapiens_hsa041150.75404403
78Shigellosis_Homo sapiens_hsa051310.73629932
79Pancreatic cancer_Homo sapiens_hsa052120.71829125
80Acute myeloid leukemia_Homo sapiens_hsa052210.70797408
81Leishmaniasis_Homo sapiens_hsa051400.70612720
82Thyroid cancer_Homo sapiens_hsa052160.68611615
83mTOR signaling pathway_Homo sapiens_hsa041500.68058013
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65966408
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64949347
86Graft-versus-host disease_Homo sapiens_hsa053320.64539609
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64181413
88Regulation of autophagy_Homo sapiens_hsa041400.64028639
89HTLV-I infection_Homo sapiens_hsa051660.63614764
90Phagosome_Homo sapiens_hsa041450.62672282
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61996342
92Prion diseases_Homo sapiens_hsa050200.61623587
93Non-small cell lung cancer_Homo sapiens_hsa052230.61338245
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56639273
95Viral myocarditis_Homo sapiens_hsa054160.56546464
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.55479355
97Influenza A_Homo sapiens_hsa051640.54929694
98Apoptosis_Homo sapiens_hsa042100.52925946
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52025007
100Carbon metabolism_Homo sapiens_hsa012000.50757529
101Chemokine signaling pathway_Homo sapiens_hsa040620.49823599
102N-Glycan biosynthesis_Homo sapiens_hsa005100.49225163
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48048477
104Vibrio cholerae infection_Homo sapiens_hsa051100.47837314
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46516013
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45667987
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.45347226
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.44725693
109Type I diabetes mellitus_Homo sapiens_hsa049400.43411901
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.42707127
111Sulfur metabolism_Homo sapiens_hsa009200.42402673
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41716628
113Fructose and mannose metabolism_Homo sapiens_hsa000510.41655089
114Hepatitis B_Homo sapiens_hsa051610.41639298
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41341654
116Prolactin signaling pathway_Homo sapiens_hsa049170.41178417
117Small cell lung cancer_Homo sapiens_hsa052220.40781372
118Biosynthesis of amino acids_Homo sapiens_hsa012300.40212989
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39721189
120ABC transporters_Homo sapiens_hsa020100.38387566
121Insulin signaling pathway_Homo sapiens_hsa049100.37117894
122Platelet activation_Homo sapiens_hsa046110.36846180
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.36759513
124Viral carcinogenesis_Homo sapiens_hsa052030.33062487
125Circadian rhythm_Homo sapiens_hsa047100.32552938
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.32205392
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31927377
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31863491
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30807694
130Osteoclast differentiation_Homo sapiens_hsa043800.30709160
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30251865
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29213832
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29074152
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28640677
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.26819251
136Metabolic pathways_Homo sapiens_hsa011000.26565007
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26329482
138Colorectal cancer_Homo sapiens_hsa052100.25888222
139Oocyte meiosis_Homo sapiens_hsa041140.25386848
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25146123
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24822828
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23534294
143African trypanosomiasis_Homo sapiens_hsa051430.20679526
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.20307593
145Salmonella infection_Homo sapiens_hsa051320.19106408
146Tuberculosis_Homo sapiens_hsa051520.18243997

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