ARG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.98437904
2epoxygenase P450 pathway (GO:0019373)8.03118426
3omega-hydroxylase P450 pathway (GO:0097267)7.89733078
4L-phenylalanine catabolic process (GO:0006559)7.45044172
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45044172
6L-phenylalanine metabolic process (GO:0006558)7.11939256
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11939256
8aromatic amino acid family catabolic process (GO:0009074)6.70955459
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.48427605
10tryptophan catabolic process (GO:0006569)6.04789328
11indole-containing compound catabolic process (GO:0042436)6.04789328
12indolalkylamine catabolic process (GO:0046218)6.04789328
13kynurenine metabolic process (GO:0070189)5.92007253
14drug metabolic process (GO:0017144)5.90440091
15bile acid biosynthetic process (GO:0006699)5.82914919
16oxidative demethylation (GO:0070989)5.82375164
17negative regulation of fibrinolysis (GO:0051918)5.72241765
18tryptophan metabolic process (GO:0006568)5.70213104
19peptidyl-glutamic acid carboxylation (GO:0017187)5.65805171
20protein carboxylation (GO:0018214)5.65805171
21* urea metabolic process (GO:0019627)5.65227581
22* urea cycle (GO:0000050)5.65227581
23glyoxylate metabolic process (GO:0046487)5.62277994
24complement activation, alternative pathway (GO:0006957)5.55739735
25high-density lipoprotein particle remodeling (GO:0034375)5.54139136
26alpha-linolenic acid metabolic process (GO:0036109)5.50142074
27regulation of fibrinolysis (GO:0051917)5.43607275
28regulation of protein activation cascade (GO:2000257)5.37899953
29sulfur amino acid catabolic process (GO:0000098)5.22693651
30phenylpropanoid metabolic process (GO:0009698)5.20918149
31cysteine metabolic process (GO:0006534)5.16702960
32* nitrogen cycle metabolic process (GO:0071941)5.14392482
33regulation of complement activation (GO:0030449)5.04165991
34regulation of plasminogen activation (GO:0010755)4.99652138
35serine family amino acid catabolic process (GO:0009071)4.97534744
36bile acid metabolic process (GO:0008206)4.97452467
37regulation of cholesterol esterification (GO:0010872)4.96777889
38negative regulation of protein activation cascade (GO:2000258)4.94549856
39regulation of humoral immune response (GO:0002920)4.94012657
40reverse cholesterol transport (GO:0043691)4.88785160
41aromatic amino acid family metabolic process (GO:0009072)4.87431865
42negative regulation of hemostasis (GO:1900047)4.86732658
43negative regulation of blood coagulation (GO:0030195)4.86732658
44regulation of triglyceride catabolic process (GO:0010896)4.86650782
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84360114
46killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.84151385
47disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.84151385
48plasma lipoprotein particle remodeling (GO:0034369)4.83399693
49protein-lipid complex remodeling (GO:0034368)4.83399693
50macromolecular complex remodeling (GO:0034367)4.83399693
51tyrosine metabolic process (GO:0006570)4.77378018
52phospholipid efflux (GO:0033700)4.76907911
53homocysteine metabolic process (GO:0050667)4.66115959
54negative regulation of sterol transport (GO:0032372)4.57385083
55negative regulation of cholesterol transport (GO:0032375)4.57385083
56amino-acid betaine metabolic process (GO:0006577)4.56066516
57plasma lipoprotein particle clearance (GO:0034381)4.54471516
58triglyceride homeostasis (GO:0070328)4.54106069
59acylglycerol homeostasis (GO:0055090)4.54106069
60* alpha-amino acid catabolic process (GO:1901606)4.48524039
61alkaloid metabolic process (GO:0009820)4.44514777
62ethanol metabolic process (GO:0006067)4.43277416
63lysine catabolic process (GO:0006554)4.42050991
64lysine metabolic process (GO:0006553)4.42050991
65positive regulation of hemostasis (GO:1900048)4.40467099
66positive regulation of blood coagulation (GO:0030194)4.40467099
67negative regulation of coagulation (GO:0050819)4.39223864
68negative regulation of wound healing (GO:0061045)4.38075277
69S-adenosylmethionine metabolic process (GO:0046500)4.32093016
70cholesterol efflux (GO:0033344)4.29569702
71indolalkylamine metabolic process (GO:0006586)4.28711699
72hormone catabolic process (GO:0042447)4.27410251
73bile acid and bile salt transport (GO:0015721)4.25355536
74coenzyme catabolic process (GO:0009109)4.24379168
75cellular glucuronidation (GO:0052695)4.24288714
76cytolysis (GO:0019835)4.23074507
77cellular ketone body metabolic process (GO:0046950)4.22861232
78imidazole-containing compound metabolic process (GO:0052803)4.21439967
79glycine metabolic process (GO:0006544)4.20695425
80cellular biogenic amine catabolic process (GO:0042402)4.19954223
81amine catabolic process (GO:0009310)4.19954223
82negative regulation of complement activation (GO:0045916)4.14717626
83fibrinolysis (GO:0042730)4.13617340
84* cellular amino acid catabolic process (GO:0009063)4.10964467
85glutamate metabolic process (GO:0006536)4.08938369
86benzene-containing compound metabolic process (GO:0042537)4.07069368
87positive regulation of coagulation (GO:0050820)4.06150952
88plasma lipoprotein particle assembly (GO:0034377)4.05476440
89low-density lipoprotein particle remodeling (GO:0034374)4.04286885
90aldehyde catabolic process (GO:0046185)4.00688603
91ethanol oxidation (GO:0006069)3.98499356
92serine family amino acid metabolic process (GO:0009069)3.98226445
93positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.97090503
94dicarboxylic acid biosynthetic process (GO:0043650)3.92734232
95cellular modified amino acid catabolic process (GO:0042219)3.89858595
96complement activation (GO:0006956)3.85070320
97complement activation, classical pathway (GO:0006958)3.82316557
98protein activation cascade (GO:0072376)3.81947204
99positive regulation of lipoprotein lipase activity (GO:0051006)3.81411223
100positive regulation of triglyceride lipase activity (GO:0061365)3.81411223
101drug catabolic process (GO:0042737)3.80728034
102cofactor catabolic process (GO:0051187)3.80038064
103negative regulation of lipase activity (GO:0060192)3.80034681
104blood coagulation, intrinsic pathway (GO:0007597)3.79096838
105* arginine metabolic process (GO:0006525)3.78702133
106positive regulation of lipid catabolic process (GO:0050996)3.78435564
107acute inflammatory response (GO:0002526)3.78151359
108very-low-density lipoprotein particle assembly (GO:0034379)3.77174980
109glucuronate metabolic process (GO:0019585)3.76897896
110uronic acid metabolic process (GO:0006063)3.76897896
111serine family amino acid biosynthetic process (GO:0009070)3.75406615
112phospholipid homeostasis (GO:0055091)3.74086706
113cholesterol homeostasis (GO:0042632)3.70749908
114plasma lipoprotein particle organization (GO:0071827)3.69596014
115sterol homeostasis (GO:0055092)3.65690019
116ketone body metabolic process (GO:1902224)3.64927215
117protein-lipid complex assembly (GO:0065005)3.64875995
118* organic acid catabolic process (GO:0016054)3.61186213
119* carboxylic acid catabolic process (GO:0046395)3.61186213
120opsonization (GO:0008228)3.59676326
121acute-phase response (GO:0006953)3.59466248
122regulation of bile acid biosynthetic process (GO:0070857)3.56660590
123response to mercury ion (GO:0046689)3.55041823
124regulation of acute inflammatory response (GO:0002673)3.53413548
125short-chain fatty acid metabolic process (GO:0046459)3.52323453
126flavonoid metabolic process (GO:0009812)3.52158179
127acetyl-CoA metabolic process (GO:0006084)3.52084743
128heme transport (GO:0015886)3.50356447
129lipoprotein metabolic process (GO:0042157)3.50180857
130regulation of lipoprotein particle clearance (GO:0010984)3.48802447
131positive regulation of fatty acid biosynthetic process (GO:0045723)3.41162584
132intestinal cholesterol absorption (GO:0030299)3.39393839
133xenobiotic metabolic process (GO:0006805)3.38831554
134negative regulation of humoral immune response (GO:0002921)3.38424695
135steroid catabolic process (GO:0006706)3.38201211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.22065029
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03620263
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83292859
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.36813363
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16565088
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00118261
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80614302
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92090039
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90790949
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00933630
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6945876
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95125478
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91387299
14CLOCK_20551151_ChIP-Seq_293T_Human1.66015499
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55289749
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.55138300
17HTT_18923047_ChIP-ChIP_STHdh_Human1.46075771
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34516271
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.34133738
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30403492
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29609646
22GATA1_22025678_ChIP-Seq_K562_Human1.20249539
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15742132
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14726442
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14257962
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.13331502
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12427488
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10307865
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06286583
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06223391
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03749838
32* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00136484
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00129689
34* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99780185
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92601141
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91638946
37HNFA_21074721_ChIP-Seq_CACO-2_Human0.91108615
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90124156
39NFE2_27457419_Chip-Seq_LIVER_Mouse0.89023623
40GATA6_21074721_ChIP-Seq_CACO-2_Human0.88607498
41GATA4_25053715_ChIP-Seq_YYC3_Human0.87781761
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85926038
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84178293
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83593827
45BP1_19119308_ChIP-ChIP_Hs578T_Human0.79276283
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78507263
47SPI1_20517297_ChIP-Seq_HL60_Human0.76116924
48SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76081996
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.75470312
50AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75080567
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74551216
52NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74551216
53PHF8_20622853_ChIP-Seq_HELA_Human0.73967682
54EGR1_19032775_ChIP-ChIP_M12_Human0.72575125
55KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71279238
56* EZH2_27294783_Chip-Seq_NPCs_Mouse0.70671650
57NFYA_21822215_ChIP-Seq_K562_Human0.70297967
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69879836
59RARA_24833708_ChIP-Seq_LIVER_Mouse0.69362742
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68730069
61* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67274028
62* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66623076
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66451633
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66273352
65TP63_17297297_ChIP-ChIP_HaCaT_Human0.66162448
66SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66106035
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65883212
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65547445
69CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64902616
70TCF4_18268006_ChIP-ChIP_LS174T_Human0.64400855
71* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63731163
72LXR_22292898_ChIP-Seq_THP-1_Human0.63122573
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.62339745
74ZNF263_19887448_ChIP-Seq_K562_Human0.61729891
75* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61679499
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.61395779
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.61382807
78* IRF8_27001747_Chip-Seq_BMDM_Mouse0.61072066
79ETV2_25802403_ChIP-Seq_MESCs_Mouse0.60965636
80PIAS1_25552417_ChIP-Seq_VCAP_Human0.60883214
81MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60838876
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59948234
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59828561
84IRF1_19129219_ChIP-ChIP_H3396_Human0.59826298
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.59519087
86ER_23166858_ChIP-Seq_MCF-7_Human0.59434237
87SOX2_21211035_ChIP-Seq_LN229_Human0.59371392
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.59225425
89CEBPB_22108803_ChIP-Seq_LS180_Human0.58871799
90P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58585830
91* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58226808
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58072359
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58050970
94ETV1_20927104_ChIP-Seq_GIST48_Human0.57628752
95ERG_20517297_ChIP-Seq_VCAP_Human0.57552256
96TP63_23658742_ChIP-Seq_EP156T_Human0.56658689
97VDR_24787735_ChIP-Seq_THP-1_Human0.56420977
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.56251139
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.55996873
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.55755010
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.55400649
102TP53_18474530_ChIP-ChIP_U2OS_Human0.55330504
103* FOXA1_25552417_ChIP-Seq_VCAP_Human0.55155753
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54946251
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.53841223
106RAC3_21632823_ChIP-Seq_H3396_Human0.53764033
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53011602
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52870946
109* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52512317
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52357676
111BRD4_27068464_Chip-Seq_AML-cells_Mouse0.51779474
112AR_20517297_ChIP-Seq_VCAP_Human0.51585644
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50764435
114GATA6_25053715_ChIP-Seq_YYC3_Human0.50268120
115SOX2_20726797_ChIP-Seq_SW620_Human0.49828079
116GATA1_19941826_ChIP-Seq_K562_Human0.48596699
117GATA2_19941826_ChIP-Seq_K562_Human0.47750405
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47650978
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.46157440
120* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45972483
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.45521768
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45453745
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.45057058
124* ESET_19884257_ChIP-Seq_ESCs_Mouse0.43994988
125P53_21459846_ChIP-Seq_SAOS-2_Human0.43563257
126TAF2_19829295_ChIP-Seq_ESCs_Human0.43302713
127STAT1_17558387_ChIP-Seq_HELA_Human0.42953704
128* MYC_19915707_ChIP-ChIP_AK7_Human0.42818192
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.42176174
130CBP_21632823_ChIP-Seq_H3396_Human0.41642437
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40001842
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.39496501
133BCAT_22108803_ChIP-Seq_LS180_Human0.39391148
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.39032990
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.38440442
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.38161490
137CDX2_22108803_ChIP-Seq_LS180_Human0.37381470
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.37229730
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.36087489
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.36051704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.09224895
2MP0005360_urolithiasis7.28459907
3MP0005085_abnormal_gallbladder_physiolo6.28909106
4MP0005365_abnormal_bile_salt6.08660797
5MP0008875_abnormal_xenobiotic_pharmacok4.97980353
6MP0003806_abnormal_nucleotide_metabolis4.16033141
7MP0003252_abnormal_bile_duct3.82807373
8MP0010329_abnormal_lipoprotein_level3.56189602
9MP0009840_abnormal_foam_cell3.49946795
10MP0005083_abnormal_biliary_tract3.00537424
11MP0003195_calcinosis2.82036376
12* MP0005332_abnormal_amino_acid2.67154653
13MP0001666_abnormal_nutrient_absorption2.52732999
14MP0003191_abnormal_cellular_cholesterol2.38670866
15MP0000609_abnormal_liver_physiology2.19567207
16MP0004019_abnormal_vitamin_homeostasis2.14245358
17MP0002118_abnormal_lipid_homeostasis2.09065585
18MP0005319_abnormal_enzyme/_coenzyme1.85670206
19MP0003868_abnormal_feces_composition1.83091131
20MP0009697_abnormal_copulation1.67950431
21MP0005584_abnormal_enzyme/coenzyme_acti1.58866855
22MP0003011_delayed_dark_adaptation1.52492550
23MP0005451_abnormal_body_composition1.52446941
24* MP0001764_abnormal_homeostasis1.48520440
25MP0003705_abnormal_hypodermis_morpholog1.34895454
26MP0003186_abnormal_redox_activity1.34188654
27MP0000604_amyloidosis1.29832974
28MP0003656_abnormal_erythrocyte_physiolo1.27041526
29MP0009643_abnormal_urine_homeostasis1.26558230
30* MP0000598_abnormal_liver_morphology1.15702499
31MP0009764_decreased_sensitivity_to1.15566699
32MP0002254_reproductive_system_inflammat1.10386938
33MP0009763_increased_sensitivity_to1.07670748
34MP0009785_altered_susceptibility_to1.06877924
35MP0005647_abnormal_sex_gland1.04573469
36* MP0002138_abnormal_hepatobiliary_system1.03921152
37MP0008469_abnormal_protein_level1.00627909
38MP0001915_intracranial_hemorrhage0.95647283
39MP0005408_hypopigmentation0.94358312
40MP0003436_decreased_susceptibility_to0.93454540
41MP0005636_abnormal_mineral_homeostasis0.91039203
42* MP0009642_abnormal_blood_homeostasis0.89563380
43MP0010368_abnormal_lymphatic_system0.89043735
44MP0003690_abnormal_glial_cell0.85592169
45MP0005464_abnormal_platelet_physiology0.79300235
46MP0002078_abnormal_glucose_homeostasis0.77402801
47MP0005084_abnormal_gallbladder_morpholo0.77025412
48MP0009053_abnormal_anal_canal0.75802702
49* MP0005376_homeostasis/metabolism_phenot0.75400371
50MP0009765_abnormal_xenobiotic_induced0.74983543
51MP0005670_abnormal_white_adipose0.72788045
52MP0006036_abnormal_mitochondrial_physio0.72476752
53MP0005334_abnormal_fat_pad0.71808730
54MP0005187_abnormal_penis_morphology0.70804377
55MP0002971_abnormal_brown_adipose0.69709158
56MP0003303_peritoneal_inflammation0.69182709
57MP0001851_eye_inflammation0.67432013
58MP0003724_increased_susceptibility_to0.67297418
59MP0004130_abnormal_muscle_cell0.67261458
60MP0005220_abnormal_exocrine_pancreas0.66964002
61MP0003075_altered_response_to0.66477807
62MP0005535_abnormal_body_temperature0.64783161
63MP0001756_abnormal_urination0.64368490
64MP0003329_amyloid_beta_deposits0.63679205
65MP0005023_abnormal_wound_healing0.62295998
66MP0005058_abnormal_lysosome_morphology0.61392306
67MP0000639_abnormal_adrenal_gland0.60042176
68MP0002876_abnormal_thyroid_physiology0.59856013
69MP0005248_abnormal_Harderian_gland0.59554644
70MP0001545_abnormal_hematopoietic_system0.56596287
71MP0005397_hematopoietic_system_phenotyp0.56596287
72MP0005266_abnormal_metabolism0.55639894
73MP0001661_extended_life_span0.55260734
74* MP0005025_abnormal_response_to0.55228475
75MP0002282_abnormal_trachea_morphology0.54353806
76MP0010234_abnormal_vibrissa_follicle0.53842187
77MP0004782_abnormal_surfactant_physiolog0.53763187
78MP0003638_abnormal_response/metabolism_0.52741061
79MP0005395_other_phenotype0.52282520
80MP0003879_abnormal_hair_cell0.51909142
81MP0002136_abnormal_kidney_physiology0.51411559
82MP0005448_abnormal_energy_balance0.51335345
83MP0005166_decreased_susceptibility_to0.51298856
84MP0006082_CNS_inflammation0.50434830
85MP0000685_abnormal_immune_system0.49455645
86MP0002796_impaired_skin_barrier0.49443520
87MP0001845_abnormal_inflammatory_respons0.48818781
88MP0008873_increased_physiological_sensi0.48571359
89MP0003878_abnormal_ear_physiology0.46975342
90MP0005377_hearing/vestibular/ear_phenot0.46975342
91MP0005501_abnormal_skin_physiology0.46052126
92MP0003718_maternal_effect0.45174489
93MP0002928_abnormal_bile_duct0.45112450
94MP0008874_decreased_physiological_sensi0.43061993
95MP0000249_abnormal_blood_vessel0.42949408
96MP0001881_abnormal_mammary_gland0.42032718
97MP0004381_abnormal_hair_follicle0.41730237
98MP0002822_catalepsy0.40783753
99MP0006035_abnormal_mitochondrial_morpho0.40521144
100MP0003953_abnormal_hormone_level0.39955385
101* MP0002419_abnormal_innate_immunity0.38574324
102MP0000579_abnormal_nail_morphology0.38280920
103MP0002168_other_aberrant_phenotype0.37832370
104MP0004883_abnormal_blood_vessel0.37305266
105MP0000467_abnormal_esophagus_morphology0.36620375
106MP0003453_abnormal_keratinocyte_physiol0.36612995
107MP0005164_abnormal_response_to0.36027371
108MP0005666_abnormal_adipose_tissue0.36021898
109MP0008872_abnormal_physiological_respon0.34899094
110MP0004947_skin_inflammation0.34613178
111MP0002132_abnormal_respiratory_system0.34233606
112MP0001853_heart_inflammation0.33358889
113MP0001533_abnormal_skeleton_physiology0.33262023
114MP0009115_abnormal_fat_cell0.32935175
115MP0001243_abnormal_dermal_layer0.32588089
116MP0000230_abnormal_systemic_arterial0.32293533
117MP0000858_altered_metastatic_potential0.30788611
118MP0003172_abnormal_lysosome_physiology0.30074306
119MP0002332_abnormal_exercise_endurance0.29804162
120MP0001800_abnormal_humoral_immune0.28839695
121MP0009931_abnormal_skin_appearance0.28311503
122MP0002249_abnormal_larynx_morphology0.27593089
123MP0010155_abnormal_intestine_physiology0.27237556

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.53507532
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.25529141
3Intrahepatic cholestasis (HP:0001406)7.02265385
4* Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57948216
5Prolonged partial thromboplastin time (HP:0003645)6.56260318
6Xanthomatosis (HP:0000991)6.28856710
7Hypobetalipoproteinemia (HP:0003563)6.24078980
8Complement deficiency (HP:0004431)5.68725419
9Hyperlipoproteinemia (HP:0010980)5.55524292
10Joint hemorrhage (HP:0005261)5.16930182
11Hypolipoproteinemia (HP:0010981)4.70442755
12Abnormality of the common coagulation pathway (HP:0010990)4.63933933
13Epidermoid cyst (HP:0200040)4.49067573
14Abnormality of complement system (HP:0005339)4.38653425
15* Hyperammonemia (HP:0001987)4.35846212
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35812953
17Abnormality of methionine metabolism (HP:0010901)4.18487110
18Hyperglycinemia (HP:0002154)4.17175067
19Hypoalphalipoproteinemia (HP:0003233)4.16346731
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.12823263
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09336615
22Ketosis (HP:0001946)4.07214657
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98731141
24Fat malabsorption (HP:0002630)3.97050408
25Systemic lupus erythematosus (HP:0002725)3.83283012
26Hypoglycemic coma (HP:0001325)3.74553708
27Abnormality of the intrinsic pathway (HP:0010989)3.69963604
28Hyperglycinuria (HP:0003108)3.67497465
29Abnormality of glycine metabolism (HP:0010895)3.65162705
30Abnormality of serine family amino acid metabolism (HP:0010894)3.65162705
31Hypercholesterolemia (HP:0003124)3.63569111
32Conjugated hyperbilirubinemia (HP:0002908)3.54925835
33* Abnormality of pyrimidine metabolism (HP:0004353)3.45682451
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27818638
35Hyperbilirubinemia (HP:0002904)3.24979217
36Abnormality of fatty-acid metabolism (HP:0004359)3.20956731
37Myocardial infarction (HP:0001658)3.20363940
38Osteomalacia (HP:0002749)3.12753097
39Glomerulonephritis (HP:0000099)3.01594840
40Steatorrhea (HP:0002570)3.00943237
41Recurrent gram-negative bacterial infections (HP:0005420)2.98355946
42Abnormality of serum amino acid levels (HP:0003112)2.94558705
43Hepatocellular carcinoma (HP:0001402)2.93735750
44Spontaneous abortion (HP:0005268)2.91839825
45Ketoacidosis (HP:0001993)2.89289866
46* Abnormality of nucleobase metabolism (HP:0010932)2.88686887
47Skin nodule (HP:0200036)2.86279654
48Delayed CNS myelination (HP:0002188)2.84366042
49Gangrene (HP:0100758)2.84139020
50Purpura (HP:0000979)2.81450144
51Hypochromic microcytic anemia (HP:0004840)2.73964557
52Vascular calcification (HP:0004934)2.65478398
53Abnormality of purine metabolism (HP:0004352)2.62779813
54Metabolic acidosis (HP:0001942)2.61503636
55Mitral stenosis (HP:0001718)2.49803648
56Lethargy (HP:0001254)2.47325047
57Fair hair (HP:0002286)2.47036523
58Amyloidosis (HP:0011034)2.45587976
59Gingival bleeding (HP:0000225)2.44675833
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43411239
61Dicarboxylic aciduria (HP:0003215)2.43411239
62Hypoglycemic seizures (HP:0002173)2.40280122
63Spastic diplegia (HP:0001264)2.39812965
64Abnormal gallbladder morphology (HP:0012437)2.38079933
65Menorrhagia (HP:0000132)2.37596615
66Acanthocytosis (HP:0001927)2.36672024
67Gout (HP:0001997)2.35793783
68Epistaxis (HP:0000421)2.34798991
69Cardiovascular calcification (HP:0011915)2.34274427
70Cholelithiasis (HP:0001081)2.31979211
71Reduced antithrombin III activity (HP:0001976)2.30782719
72Neonatal onset (HP:0003623)2.28801560
73Neonatal hypoglycemia (HP:0001998)2.28346271
74Cerebral edema (HP:0002181)2.28248935
75Abnormal gallbladder physiology (HP:0012438)2.26119754
76Cholecystitis (HP:0001082)2.26119754
77Esophageal varix (HP:0002040)2.23048670
78* Irritability (HP:0000737)2.22897459
79Thrombophlebitis (HP:0004418)2.19428814
80Increased serum ferritin (HP:0003281)2.18813367
81Pancreatitis (HP:0001733)2.16834139
82Elevated alkaline phosphatase (HP:0003155)2.14017555
83Malnutrition (HP:0004395)2.12467347
84Nephritis (HP:0000123)2.11243804
85Late onset (HP:0003584)2.10975892
86Sensorimotor neuropathy (HP:0007141)2.08356192
87Brushfield spots (HP:0001088)2.07851055
88Arthropathy (HP:0003040)2.07747306
89Joint swelling (HP:0001386)2.07233725
90Abnormality of iron homeostasis (HP:0011031)2.02529776
91Hemorrhage of the eye (HP:0011885)2.01996526
92Generalized aminoaciduria (HP:0002909)1.97688798
93Abnormality of transition element cation homeostasis (HP:0011030)1.95880077
94Abnormality of alkaline phosphatase activity (HP:0004379)1.95525256
95Opisthotonus (HP:0002179)1.94722749
96Increased mean platelet volume (HP:0011877)1.94337196
97Hyperinsulinemic hypoglycemia (HP:0000825)1.93137782
98Enlarged kidneys (HP:0000105)1.93040483
99Abnormality of the gallbladder (HP:0005264)1.91700139
100* Vomiting (HP:0002013)1.91415880
101Abnormal platelet volume (HP:0011876)1.88873810
102Rickets (HP:0002748)1.88598726
103Pulmonary embolism (HP:0002204)1.88046478
104Hypochromic anemia (HP:0001931)1.87500268
105Poikilocytosis (HP:0004447)1.86472082
106Generalized hypopigmentation of hair (HP:0011358)1.85796445
107Abnormality of the Achilles tendon (HP:0005109)1.85171781
108Hydroxyprolinuria (HP:0003080)1.81023791
109Abnormality of proline metabolism (HP:0010907)1.81023791
110Alkalosis (HP:0001948)1.80582727
111Hyperphosphaturia (HP:0003109)1.78933173
112Hypophosphatemic rickets (HP:0004912)1.78709691
113Abnormal cartilage morphology (HP:0002763)1.78634313
114Abnormal enzyme/coenzyme activity (HP:0012379)1.77834653
115Elevated hepatic transaminases (HP:0002910)1.74257992
116Hyperglycemia (HP:0003074)1.73838016
117Renal cortical cysts (HP:0000803)1.70994661
118Abnormal platelet function (HP:0011869)1.69392335
119Impaired platelet aggregation (HP:0003540)1.69392335
120Abnormal biliary tract physiology (HP:0012439)1.66196556
121Bile duct proliferation (HP:0001408)1.66196556
122Status epilepticus (HP:0002133)1.66090658
123Abnormality of vitamin metabolism (HP:0100508)1.65050764
124Periodontitis (HP:0000704)1.64180337
125Pruritus (HP:0000989)1.64087939
126Reticulocytosis (HP:0001923)1.63918761
127Polycythemia (HP:0001901)1.63345201
128Abnormality of urine glucose concentration (HP:0011016)1.61912560
129Glycosuria (HP:0003076)1.61912560
130Increased IgE level (HP:0003212)1.61058115
131Atrioventricular block (HP:0001678)1.58616841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.19730366
2ERN14.26292749
3FGFR44.20411579
4SIK13.91177385
5TAOK33.37881950
6PKN22.68848258
7INSRR2.59505878
8MST1R2.58749097
9PRPF4B2.58137926
10ERBB42.51160232
11MAP3K62.18762277
12FLT32.10128673
13TYK21.99402586
14MAP2K41.96489872
15PIK3CG1.93695595
16TRIB31.89706754
17PIK3CA1.89337041
18ABL21.79987227
19BLK1.78473532
20MAPK111.69808444
21MAP3K21.69274770
22TNK21.62637701
23PTK61.61588274
24DAPK21.49504820
25MAP3K141.48095170
26FRK1.46253924
27EPHB11.45905544
28NEK91.43357012
29RIPK41.42251584
30GRK61.33949956
31TBK11.30908381
32JAK21.28901738
33IRAK31.27826817
34LATS11.26907494
35IRAK41.17400328
36TAOK21.15852458
37ERBB21.15563764
38NLK1.13276519
39JAK11.12912868
40KDR1.11137070
41KSR21.09861448
42TAOK11.09579242
43EPHA21.06368382
44RIPK11.05810008
45PINK11.05206291
46MAP3K71.05052806
47CSK1.04148879
48FGFR21.04063278
49MET1.02548513
50MAPK40.97782052
51EPHA30.97594721
52CDK60.96921318
53MAP2K30.95854454
54CSF1R0.92587783
55SYK0.90900105
56PRKAA20.90135268
57FES0.88651091
58MAPK150.88632111
59MAP3K30.84073754
60TEC0.81971003
61PTK20.79625418
62SGK20.79498143
63MAP3K130.77422594
64MAP3K100.76107627
65HCK0.75966836
66CAMK1D0.75521503
67PRKACG0.75409246
68TRPM70.74214416
69FER0.74198567
70CDK120.74110858
71BMX0.73586492
72PRKCZ0.73122029
73CAMKK20.72889041
74IKBKE0.70647459
75FGFR30.70237382
76DYRK1B0.69321384
77GSK3A0.67896717
78MAP3K110.67542084
79CAMK2G0.67447088
80ARAF0.66129621
81MAPK120.65101501
82NTRK30.64569270
83SGK4940.64333849
84SGK2230.64333849
85YES10.62024591
86PBK0.60735417
87IGF1R0.59647638
88SGK10.58111858
89ZAP700.56223722
90PRKG10.55665340
91TGFBR20.54874379
92TXK0.54621514
93SGK30.53006986
94PRKCG0.52820216
95MAP4K10.52256663
96EGFR0.50470553
97MAP2K60.49845914
98PDPK10.48978067
99PRKCQ0.48314823
100LCK0.48289607
101PRKAA10.45501068
102RAF10.44390161
103AKT30.44241306
104EPHB20.42693806
105PRKACA0.41718522
106STK38L0.41460595
107STK30.41338535
108EIF2AK10.40410704
109MAPK70.40369997
110MAP2K10.38860629
111TIE10.38408330
112MARK20.38096963
113ABL10.37724686
114KIT0.36108320
115PRKCB0.35400442
116CSNK1D0.34779470
117BTK0.33270492
118CSNK1G10.33226503
119IKBKB0.31440140
120MAP3K10.31138341
121PKN10.30796918
122RET0.30784811
123PDK10.30581250
124LYN0.29338560
125GRK10.28261426
126CDK40.27853641
127JAK30.25650350
128FGFR10.25276481
129PRKD10.24917146
130CAMK1G0.24327157
131CHUK0.23599428
132PRKCA0.22872155
133MAP2K20.22556282
134ITK0.22526245
135MAP3K50.22494105
136IRAK10.20990543

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51601123
2Nitrogen metabolism_Homo sapiens_hsa009103.56006384
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43234095
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34750497
5* Arginine biosynthesis_Homo sapiens_hsa002203.04240951
6Complement and coagulation cascades_Homo sapiens_hsa046102.99526117
7Tryptophan metabolism_Homo sapiens_hsa003802.65494444
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62357207
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53035316
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49570012
11Fatty acid degradation_Homo sapiens_hsa000712.43136261
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30839693
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29492712
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20673119
15Staphylococcus aureus infection_Homo sapiens_hsa051502.19825227
16Peroxisome_Homo sapiens_hsa041462.06344229
17Butanoate metabolism_Homo sapiens_hsa006502.02487796
18Chemical carcinogenesis_Homo sapiens_hsa052042.01324884
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00132873
20Histidine metabolism_Homo sapiens_hsa003401.97087188
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91192913
22Caffeine metabolism_Homo sapiens_hsa002321.89959620
23PPAR signaling pathway_Homo sapiens_hsa033201.86260415
24Propanoate metabolism_Homo sapiens_hsa006401.83991381
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.79725861
26Fatty acid metabolism_Homo sapiens_hsa012121.74562330
27beta-Alanine metabolism_Homo sapiens_hsa004101.71321362
28Retinol metabolism_Homo sapiens_hsa008301.71109355
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71100455
30Phenylalanine metabolism_Homo sapiens_hsa003601.66263926
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58124147
32Selenocompound metabolism_Homo sapiens_hsa004501.49412641
33Tyrosine metabolism_Homo sapiens_hsa003501.46224881
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45967054
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45336400
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45090605
37Bile secretion_Homo sapiens_hsa049761.44242606
38Starch and sucrose metabolism_Homo sapiens_hsa005001.34628956
39Sulfur metabolism_Homo sapiens_hsa009201.30605828
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.28827026
41Pyruvate metabolism_Homo sapiens_hsa006201.28538267
42Fatty acid elongation_Homo sapiens_hsa000621.26886965
43Folate biosynthesis_Homo sapiens_hsa007901.22267471
44ABC transporters_Homo sapiens_hsa020101.17069050
45* Biosynthesis of amino acids_Homo sapiens_hsa012301.15072732
46Fat digestion and absorption_Homo sapiens_hsa049751.14283239
47Steroid biosynthesis_Homo sapiens_hsa001001.12659126
48Carbon metabolism_Homo sapiens_hsa012001.09721722
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.02751075
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00516939
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95958799
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91544082
53Sulfur relay system_Homo sapiens_hsa041220.87826539
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.87523614
55* Arginine and proline metabolism_Homo sapiens_hsa003300.85134850
56Vitamin B6 metabolism_Homo sapiens_hsa007500.84345395
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84107633
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76371008
59Lysine degradation_Homo sapiens_hsa003100.75036246
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71009396
61One carbon pool by folate_Homo sapiens_hsa006700.68790722
62Glutathione metabolism_Homo sapiens_hsa004800.68560208
63Pentose phosphate pathway_Homo sapiens_hsa000300.64976235
64Glycerolipid metabolism_Homo sapiens_hsa005610.63760432
65Fatty acid biosynthesis_Homo sapiens_hsa000610.49414779
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47340215
67* Metabolic pathways_Homo sapiens_hsa011000.43213310
68Prion diseases_Homo sapiens_hsa050200.42881662
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38988047
70Galactose metabolism_Homo sapiens_hsa000520.32524904
71Linoleic acid metabolism_Homo sapiens_hsa005910.30829121
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22376965
73Fructose and mannose metabolism_Homo sapiens_hsa000510.21577183
74Insulin resistance_Homo sapiens_hsa049310.21148860
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.20883379
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.11308151
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09915783
78Glucagon signaling pathway_Homo sapiens_hsa049220.08832091
79Serotonergic synapse_Homo sapiens_hsa047260.07361175
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.06242639
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06074203
82Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2129121
83* Amoebiasis_Homo sapiens_hsa05146-0.2108293
84Other glycan degradation_Homo sapiens_hsa00511-0.1885377
85Renin-angiotensin system_Homo sapiens_hsa04614-0.1812760
86African trypanosomiasis_Homo sapiens_hsa05143-0.1740312
87Leishmaniasis_Homo sapiens_hsa05140-0.1708239
88Malaria_Homo sapiens_hsa05144-0.1690652
89Ether lipid metabolism_Homo sapiens_hsa00565-0.1681333
90Hepatitis C_Homo sapiens_hsa05160-0.1640382
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1577855
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1554070
93Platelet activation_Homo sapiens_hsa04611-0.1505614
94Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1487125
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1483224
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1386603
97Mineral absorption_Homo sapiens_hsa04978-0.1313983
98Insulin signaling pathway_Homo sapiens_hsa04910-0.1222081
99Regulation of autophagy_Homo sapiens_hsa04140-0.1178985
100Legionellosis_Homo sapiens_hsa05134-0.1150224
101Sphingolipid metabolism_Homo sapiens_hsa00600-0.1099721
102Type II diabetes mellitus_Homo sapiens_hsa04930-0.0901838
103Lysosome_Homo sapiens_hsa04142-0.0849820
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0747167
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0738551
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0528395
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0340127
108Pertussis_Homo sapiens_hsa05133-0.0322760
109AMPK signaling pathway_Homo sapiens_hsa04152-0.0292854

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