ARG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.46004824
2positive regulation of Cdc42 GTPase activity (GO:0043089)7.22160256
3angiotensin maturation (GO:0002003)6.40139738
4intestinal cholesterol absorption (GO:0030299)6.12356582
5regulation of dendritic cell antigen processing and presentation (GO:0002604)5.06505272
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.90585260
7piRNA metabolic process (GO:0034587)4.71224184
8vitamin A metabolic process (GO:0006776)4.42105934
9virion attachment to host cell (GO:0019062)4.09347724
10adhesion of symbiont to host cell (GO:0044650)4.09347724
11positive regulation of interleukin-1 beta secretion (GO:0050718)4.08578965
12regulation of interleukin-1 beta secretion (GO:0050706)4.01213237
13positive regulation of antigen processing and presentation (GO:0002579)3.98572526
14regulation of transforming growth factor beta2 production (GO:0032909)3.96680502
15protein neddylation (GO:0045116)3.96467260
16dendritic cell chemotaxis (GO:0002407)3.94470955
17regulation of Cdc42 GTPase activity (GO:0043088)3.90707829
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84710738
19positive regulation of interleukin-1 secretion (GO:0050716)3.81770648
20regulation of T-helper 1 cell differentiation (GO:0045625)3.79682437
21peptide catabolic process (GO:0043171)3.78426550
22dendritic cell migration (GO:0036336)3.64941194
23regulation of RIG-I signaling pathway (GO:0039535)3.63879327
24cullin deneddylation (GO:0010388)3.63308977
25hydrogen peroxide catabolic process (GO:0042744)3.61232739
26regulation of interleukin-1 secretion (GO:0050704)3.56806173
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.53961515
28NIK/NF-kappaB signaling (GO:0038061)3.51573367
29thyroid hormone metabolic process (GO:0042403)3.50282559
30positive regulation of interleukin-1 beta production (GO:0032731)3.48180946
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47439962
32hydrogen peroxide biosynthetic process (GO:0050665)3.47213203
33sulfate transmembrane transport (GO:1902358)3.46877631
34activation of Rac GTPase activity (GO:0032863)3.40931909
35actin filament depolymerization (GO:0030042)3.39277166
36immunoglobulin mediated immune response (GO:0016064)3.38662177
37ATP synthesis coupled proton transport (GO:0015986)3.35885833
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35885833
39positive regulation of growth hormone secretion (GO:0060124)3.35683906
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32975151
41digestive system process (GO:0022600)3.29399913
42hydrogen peroxide metabolic process (GO:0042743)3.28747950
43protein deneddylation (GO:0000338)3.28117007
44proteasome assembly (GO:0043248)3.27920167
45response to hydroperoxide (GO:0033194)3.25061692
46regulation of antigen processing and presentation (GO:0002577)3.21917036
47sphingosine metabolic process (GO:0006670)3.21454061
48protein kinase C signaling (GO:0070528)3.21199095
49diol metabolic process (GO:0034311)3.21048665
50superoxide anion generation (GO:0042554)3.19935515
51pyrimidine nucleobase catabolic process (GO:0006208)3.18129788
52negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.18111604
53regulation of mitochondrial translation (GO:0070129)3.16022397
54regulation of integrin activation (GO:0033623)3.15563119
55positive regulation of interleukin-1 production (GO:0032732)3.15379868
56positive regulation of actin filament depolymerization (GO:0030836)3.15051950
57positive regulation of T-helper cell differentiation (GO:0045624)3.14700450
58chaperone-mediated protein transport (GO:0072321)3.14306750
59ventricular cardiac muscle cell development (GO:0055015)3.14141769
60regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.14026886
61regulation of female gonad development (GO:2000194)3.13296669
62protein complex biogenesis (GO:0070271)3.13009679
63chromatin remodeling at centromere (GO:0031055)3.10141289
64detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.09558728
65adhesion of symbiont to host (GO:0044406)3.08790331
66growth hormone secretion (GO:0030252)3.08719117
67UDP-N-acetylglucosamine metabolic process (GO:0006047)3.08708800
68respiratory electron transport chain (GO:0022904)3.06489690
69regulation of activation of Janus kinase activity (GO:0010533)3.04657721
70detection of other organism (GO:0098543)3.03754020
71negative regulation of interleukin-10 production (GO:0032693)3.03619020
72drug catabolic process (GO:0042737)3.02804797
73electron transport chain (GO:0022900)3.01500130
74positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.01354288
75mitochondrial respiratory chain complex assembly (GO:0033108)3.00991798
76DNA damage response, detection of DNA damage (GO:0042769)2.99968847
77response to peptidoglycan (GO:0032494)2.99497007
78detection of bacterium (GO:0016045)2.99353528
79CENP-A containing nucleosome assembly (GO:0034080)2.98266212
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97072821
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.97072821
82NADH dehydrogenase complex assembly (GO:0010257)2.97072821
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.94464981
84termination of RNA polymerase III transcription (GO:0006386)2.94464981
85protein-cofactor linkage (GO:0018065)2.93680795
86regulation of podosome assembly (GO:0071801)2.92835487
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91502081
88DNA double-strand break processing (GO:0000729)2.91403400
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90507753
90single strand break repair (GO:0000012)2.89775732
91pericardium development (GO:0060039)2.88951985
92nucleobase catabolic process (GO:0046113)2.88544878
93reactive oxygen species biosynthetic process (GO:1903409)2.87869869
94intestinal epithelial cell development (GO:0060576)2.86686968
95alkaloid metabolic process (GO:0009820)2.86319234
96regulation of triglyceride catabolic process (GO:0010896)2.85439500
97DNA methylation involved in gamete generation (GO:0043046)2.83818289
98respiratory burst (GO:0045730)2.82829322
99sulfate transport (GO:0008272)2.82617289
100phospholipid efflux (GO:0033700)2.82003582
101leukocyte mediated cytotoxicity (GO:0001909)2.81019503
102regulation of guanylate cyclase activity (GO:0031282)2.80690983
103positive regulation of T-helper 1 type immune response (GO:0002827)2.80662937
104modified amino acid transport (GO:0072337)2.79231582
105transepithelial transport (GO:0070633)2.75762702
106positive regulation of mitochondrial fission (GO:0090141)2.74933714
107DNA replication checkpoint (GO:0000076)2.73132038
108positive regulation of triglyceride lipase activity (GO:0061365)2.71471379
109positive regulation of lipoprotein lipase activity (GO:0051006)2.71471379
110gamma-aminobutyric acid transport (GO:0015812)2.69438267
111positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.68261758
112respiratory chain complex IV assembly (GO:0008535)2.66612222
113regulation of hypersensitivity (GO:0002883)2.66358571
114synapsis (GO:0007129)2.65224370
115chronic inflammatory response (GO:0002544)2.65115459
116positive regulation of interleukin-4 production (GO:0032753)2.64569605
117water-soluble vitamin biosynthetic process (GO:0042364)2.64447049
118glycerol metabolic process (GO:0006071)2.64202427
119cell killing (GO:0001906)2.62681154
120disruption of cells of other organism (GO:0044364)2.62239154
121killing of cells of other organism (GO:0031640)2.62239154
122striated muscle atrophy (GO:0014891)2.62052534
123modulation by symbiont of host defense response (GO:0052031)2.61770597
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61770597
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61770597
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.61770597
127modulation by symbiont of host immune response (GO:0052553)2.61770597
128positive regulation by symbiont of host defense response (GO:0052509)2.61770597
129histone exchange (GO:0043486)2.61457371
130L-serine metabolic process (GO:0006563)2.61297783
131neurofilament cytoskeleton organization (GO:0060052)2.61030184
132digestion (GO:0007586)2.60804167
133negative regulation of DNA recombination (GO:0045910)2.60447372
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60204744
135establishment of integrated proviral latency (GO:0075713)2.59495139
136positive regulation of p38MAPK cascade (GO:1900745)2.58596836
137positive regulation of granulocyte chemotaxis (GO:0071624)2.58471912
138regulation of meiosis I (GO:0060631)2.58308740
139positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58261780
140female gamete generation (GO:0007292)2.57417405
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56141972
142regulation of mitotic spindle checkpoint (GO:1903504)2.56141972
143microtubule depolymerization (GO:0007019)2.50049621
144DNA replication-independent nucleosome assembly (GO:0006336)2.46497123
145DNA replication-independent nucleosome organization (GO:0034724)2.46497123
146telomere maintenance via telomerase (GO:0007004)2.44143031
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43875591
148organelle disassembly (GO:1903008)2.42520004
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42440355
150ribonucleoprotein complex disassembly (GO:0032988)2.40606716
151protein localization to mitochondrion (GO:0070585)2.37872785
152protein targeting to mitochondrion (GO:0006626)2.35989253
153protein localization to synapse (GO:0035418)2.35775171
154protein K11-linked ubiquitination (GO:0070979)2.35660894
155behavioral response to nicotine (GO:0035095)2.34638992
156rRNA modification (GO:0000154)2.31963438
157DNA replication-dependent nucleosome organization (GO:0034723)2.31332451
158DNA replication-dependent nucleosome assembly (GO:0006335)2.31332451
159establishment of protein localization to mitochondrion (GO:0072655)2.30761953
160regulation of helicase activity (GO:0051095)2.30738050
161presynaptic membrane organization (GO:0097090)2.29970395
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.29162987
163presynaptic membrane assembly (GO:0097105)2.26341251
164cytochrome complex assembly (GO:0017004)2.25998361
165regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.25023207
166inner mitochondrial membrane organization (GO:0007007)2.24926931
167spliceosomal snRNP assembly (GO:0000387)2.23057218
168hydrogen ion transmembrane transport (GO:1902600)2.20380185
169regulation of acrosome reaction (GO:0060046)2.19771827
170regulation of hexokinase activity (GO:1903299)2.18657856
171regulation of glucokinase activity (GO:0033131)2.18657856
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.18418718
173histone H2A acetylation (GO:0043968)2.17429119
174purine nucleobase biosynthetic process (GO:0009113)2.16942260
175amino acid activation (GO:0043038)2.16916948
176tRNA aminoacylation (GO:0043039)2.16916948
177tRNA aminoacylation for protein translation (GO:0006418)2.16172444
178nonmotile primary cilium assembly (GO:0035058)2.15460613
179DNA catabolic process, exonucleolytic (GO:0000738)2.15356074
180somatic diversification of immune receptors via somatic mutation (GO:0002566)2.15291651
181somatic hypermutation of immunoglobulin genes (GO:0016446)2.15291651
182anterograde axon cargo transport (GO:0008089)2.13091162
183positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.11848985
184negative regulation of telomere maintenance (GO:0032205)2.11380305
185ubiquinone metabolic process (GO:0006743)2.09955037
186protein polyglutamylation (GO:0018095)2.09270060
187regulation of cofactor metabolic process (GO:0051193)2.09150315
188regulation of coenzyme metabolic process (GO:0051196)2.09150315
1897-methylguanosine mRNA capping (GO:0006370)2.09035149
190rRNA methylation (GO:0031167)2.08823712
191positive regulation of histone H3-K4 methylation (GO:0051571)2.08811359
192anterograde synaptic vesicle transport (GO:0048490)2.06962903
193L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.06946242
194maturation of 5.8S rRNA (GO:0000460)2.06719599
195establishment of melanosome localization (GO:0032401)2.06694538
196lactate metabolic process (GO:0006089)2.05108969
197regulation of cellular amino acid metabolic process (GO:0006521)2.05100259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05189520
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.75207621
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.73385112
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.34180217
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.23619236
6* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.22963893
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17716694
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.13737061
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.11496295
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84464043
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.73508604
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70166394
13EZH2_22144423_ChIP-Seq_EOC_Human2.61565181
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61079780
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59106942
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46061269
17IGF1R_20145208_ChIP-Seq_DFB_Human2.39307001
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38056812
19ZNF274_21170338_ChIP-Seq_K562_Hela2.32884578
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.30467025
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26002917
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25418572
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21929755
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18610033
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16610130
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.16317540
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15404232
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10636857
29CDX2_20551321_ChIP-Seq_CACO-2_Human2.09032140
30VDR_22108803_ChIP-Seq_LS180_Human2.07627605
31FUS_26573619_Chip-Seq_HEK293_Human2.06701180
32* GATA4_25053715_ChIP-Seq_YYC3_Human2.05959756
33STAT1_17558387_ChIP-Seq_HELA_Human2.03168004
34CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01877193
35MYC_18555785_ChIP-Seq_MESCs_Mouse2.00763145
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97320741
37ELK1_19687146_ChIP-ChIP_HELA_Human1.97008192
38* SOX2_20726797_ChIP-Seq_SW620_Human1.90626568
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.90417353
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89773706
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.87262506
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86316831
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86187921
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84197400
45VDR_23849224_ChIP-Seq_CD4+_Human1.77231526
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76849400
47EWS_26573619_Chip-Seq_HEK293_Human1.73999599
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73412920
49TAF15_26573619_Chip-Seq_HEK293_Human1.67717612
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64680689
51E2F7_22180533_ChIP-Seq_HELA_Human1.63693279
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.63656582
53GBX2_23144817_ChIP-Seq_PC3_Human1.58449907
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.55344926
55GATA6_25053715_ChIP-Seq_YYC3_Human1.55198264
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55190834
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55083316
58FOXP3_21729870_ChIP-Seq_TREG_Human1.54547220
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.54066490
60MYC_18940864_ChIP-ChIP_HL60_Human1.53038747
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50806010
62DCP1A_22483619_ChIP-Seq_HELA_Human1.49544026
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47294071
64VDR_24787735_ChIP-Seq_THP-1_Human1.44505460
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43813989
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43674567
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.43048313
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42576651
69CDX2_22108803_ChIP-Seq_LS180_Human1.42234190
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41755619
71TTF2_22483619_ChIP-Seq_HELA_Human1.40813773
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40570080
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40546006
74IRF1_19129219_ChIP-ChIP_H3396_Human1.40512274
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.40475680
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40101911
77RXR_22108803_ChIP-Seq_LS180_Human1.39831781
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.38708289
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38230947
80P300_19829295_ChIP-Seq_ESCs_Human1.38129073
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36593371
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.34405369
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.34049284
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33483956
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33460822
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32713073
87RNF2_27304074_Chip-Seq_NSC_Mouse1.32332908
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32185331
89GABP_19822575_ChIP-Seq_HepG2_Human1.31905992
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.31723105
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31706719
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28813350
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28430031
94KLF5_25053715_ChIP-Seq_YYC3_Human1.25498877
95* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22056942
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22049866
97AR_21909140_ChIP-Seq_LNCAP_Human1.20677195
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19045101
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18377826
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17677623
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.17379584
102XRN2_22483619_ChIP-Seq_HELA_Human1.17123031
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16901169
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16717303
105* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16406635
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.14919942
107HTT_18923047_ChIP-ChIP_STHdh_Human1.14427116
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13799494
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13276935
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12738814
111TP53_22573176_ChIP-Seq_HFKS_Human1.12399483
112* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11672690
113TP63_23658742_ChIP-Seq_EP156T_Human1.11250070
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11228807
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09790860
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09453854
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09330361
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09048234
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.08885495
120REST_21632747_ChIP-Seq_MESCs_Mouse1.08140905
121MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07910777
122HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05239895
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04903640
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04370081
125* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03395937
126SMRT_27268052_Chip-Seq_Bcells_Human1.03375656
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03242098
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03030633
129CJUN_26792858_Chip-Seq_BT549_Human1.02319552
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00606267
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00227964
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99968442
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99729447
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99720153
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99056943
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98973530
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97967053
138MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97911115
139REST_18959480_ChIP-ChIP_MESCs_Mouse0.97766448
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.97710169
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97465864
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97213040
143KDM2B_26808549_Chip-Seq_REH_Human0.96860811
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96582039
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95810389
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.94224566
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.93653548
148* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92985697
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92523415
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92152004
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91681547
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91654300
153KDM5A_27292631_Chip-Seq_BREAST_Human0.91613134
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.90788819
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90189862
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90071775
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89956620
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89566832
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.89121415
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88914777
161CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88502786
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88343848
163SMAD4_21799915_ChIP-Seq_A2780_Human0.87944523
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.87888241
165* ERG_20517297_ChIP-Seq_VCAP_Human0.87786645
166MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87466761
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.87451972
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86628543
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.86097176
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85948786
171CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85486080
172RUNX1_27514584_Chip-Seq_MCF-7_Human0.85284460
173PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84986542
174AR_25329375_ChIP-Seq_VCAP_Human0.84260341
175IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84058459
176CBP_20019798_ChIP-Seq_JUKART_Human0.84058459
177CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83744354
178* PRDM14_20953172_ChIP-Seq_ESCs_Human0.83674228
179EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83370772
180BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82259809
181LXR_22158963_ChIP-Seq_LIVER_Mouse0.82001510
182ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81998918
183NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81950682
184NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81950682
185SOX2_18555785_Chip-Seq_ESCs_Mouse0.81593609
186NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80641829
187* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80214774
188RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79683911
189OCT4_18555785_Chip-Seq_ESCs_Mouse0.79026664
190CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78955255
191* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78561643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.08550228
2MP0002254_reproductive_system_inflammat4.52392817
3MP0003183_abnormal_peptide_metabolism4.47082224
4MP0001666_abnormal_nutrient_absorption3.42746598
5MP0008877_abnormal_DNA_methylation3.28284874
6MP0002822_catalepsy3.10133482
7MP0003718_maternal_effect3.03146066
8MP0002876_abnormal_thyroid_physiology2.89087595
9MP0001346_abnormal_lacrimal_gland2.88092345
10MP0001529_abnormal_vocalization2.82037082
11MP0005310_abnormal_salivary_gland2.81939747
12MP0005451_abnormal_body_composition2.70591429
13MP0003122_maternal_imprinting2.59087390
14MP0004264_abnormal_extraembryonic_tissu2.55123728
15MP0008058_abnormal_DNA_repair2.45297003
16MP0003121_genomic_imprinting2.36554539
17MP0010234_abnormal_vibrissa_follicle2.35358618
18MP0003787_abnormal_imprinting2.30364713
19MP0001835_abnormal_antigen_presentation2.22344324
20MP0009785_altered_susceptibility_to2.19046559
21MP0002148_abnormal_hypersensitivity_rea2.15108649
22MP0001188_hyperpigmentation2.14706112
23MP0001873_stomach_inflammation2.14207508
24MP0009840_abnormal_foam_cell2.11096107
25MP0001881_abnormal_mammary_gland2.11045074
26MP0004147_increased_porphyrin_level2.10557256
27MP0010352_gastrointestinal_tract_polyps2.08935133
28MP0000538_abnormal_urinary_bladder2.08041004
29MP0003436_decreased_susceptibility_to2.06273593
30MP0002277_abnormal_respiratory_mucosa1.99516767
31MP0005394_taste/olfaction_phenotype1.98574368
32MP0005499_abnormal_olfactory_system1.98574368
33MP0006292_abnormal_olfactory_placode1.96403141
34MP0008789_abnormal_olfactory_epithelium1.93587416
35MP0000462_abnormal_digestive_system1.89447404
36MP0003890_abnormal_embryonic-extraembry1.84370377
37MP0009764_decreased_sensitivity_to1.82068890
38MP0001984_abnormal_olfaction1.80367520
39MP0010155_abnormal_intestine_physiology1.78628410
40MP0003123_paternal_imprinting1.74577071
41MP0000685_abnormal_immune_system1.69715158
42MP0009046_muscle_twitch1.66940858
43MP0002736_abnormal_nociception_after1.65189892
44MP0003453_abnormal_keratinocyte_physiol1.59591485
45MP0003300_gastrointestinal_ulcer1.59306847
46MP0006276_abnormal_autonomic_nervous1.59102784
47MP0004019_abnormal_vitamin_homeostasis1.57490150
48MP0001663_abnormal_digestive_system1.55956228
49MP0003880_abnormal_central_pattern1.55883032
50MP0002419_abnormal_innate_immunity1.55322526
51MP0003567_abnormal_fetal_cardiomyocyte1.52319652
52MP0004859_abnormal_synaptic_plasticity1.51281783
53MP0006082_CNS_inflammation1.50482273
54MP0006035_abnormal_mitochondrial_morpho1.50420575
55MP0005025_abnormal_response_to1.45388432
56MP0003724_increased_susceptibility_to1.44265061
57MP0005381_digestive/alimentary_phenotyp1.44264607
58MP0004270_analgesia1.42895967
59MP0010386_abnormal_urinary_bladder1.41577397
60MP0004957_abnormal_blastocyst_morpholog1.41511589
61MP0001968_abnormal_touch/_nociception1.41477497
62MP0002735_abnormal_chemical_nociception1.40625011
63MP0008995_early_reproductive_senescence1.40191942
64MP0002272_abnormal_nervous_system1.40039949
65MP0005000_abnormal_immune_tolerance1.34062178
66MP0002837_dystrophic_cardiac_calcinosis1.33297338
67MP0004947_skin_inflammation1.30523661
68MP0001845_abnormal_inflammatory_respons1.30124806
69MP0010094_abnormal_chromosome_stability1.30021237
70MP0003866_abnormal_defecation1.29269272
71MP0002909_abnormal_adrenal_gland1.29250542
72MP0002938_white_spotting1.28057355
73MP0004782_abnormal_surfactant_physiolog1.27743625
74MP0006072_abnormal_retinal_apoptosis1.27169181
75MP0005646_abnormal_pituitary_gland1.26424758
76MP0002405_respiratory_system_inflammati1.25822895
77MP0003693_abnormal_embryo_hatching1.25224741
78MP0002234_abnormal_pharynx_morphology1.24864986
79MP0003119_abnormal_digestive_system1.23994512
80MP0009697_abnormal_copulation1.23320077
81MP0008932_abnormal_embryonic_tissue1.22207510
82MP0005647_abnormal_sex_gland1.21864787
83MP0005395_other_phenotype1.21729254
84MP0001293_anophthalmia1.20885201
85MP0000631_abnormal_neuroendocrine_gland1.20631827
86MP0009745_abnormal_behavioral_response1.20569824
87MP0002138_abnormal_hepatobiliary_system1.20325796
88MP0004510_myositis1.20277629
89MP0002139_abnormal_hepatobiliary_system1.20158585
90MP0002210_abnormal_sex_determination1.18576684
91MP0003252_abnormal_bile_duct1.17917473
92MP0003111_abnormal_nucleus_morphology1.17756560
93MP0004142_abnormal_muscle_tone1.16013777
94MP0004043_abnormal_pH_regulation1.15916553
95MP0002557_abnormal_social/conspecific_i1.14851375
96MP0003941_abnormal_skin_development1.14462516
97MP0002734_abnormal_mechanical_nocicepti1.11399999
98MP0001929_abnormal_gametogenesis1.11297459
99MP0001764_abnormal_homeostasis1.10389366
100MP0005551_abnormal_eye_electrophysiolog1.10181611
101MP0001905_abnormal_dopamine_level1.09863656
102MP0006036_abnormal_mitochondrial_physio1.07736944
103MP0003448_altered_tumor_morphology1.07177101
104MP0008875_abnormal_xenobiotic_pharmacok1.05796781
105MP0003635_abnormal_synaptic_transmissio1.05356210
106MP0001501_abnormal_sleep_pattern1.04889945
107MP0003705_abnormal_hypodermis_morpholog1.03969340
108MP0005448_abnormal_energy_balance1.03869031
109MP0002160_abnormal_reproductive_system1.03598585
110MP0003786_premature_aging1.03396422
111MP0002452_abnormal_antigen_presenting1.03203044
112MP0010329_abnormal_lipoprotein_level1.02685196
113MP0005187_abnormal_penis_morphology1.02568818
114MP0000778_abnormal_nervous_system1.02417928
115MP0002572_abnormal_emotion/affect_behav1.02053506
116MP0005167_abnormal_blood-brain_barrier1.01927646
117MP0003698_abnormal_male_reproductive1.01456625
118MP0004133_heterotaxia1.01224689
119MP0000566_synostosis1.00260959
120MP0005645_abnormal_hypothalamus_physiol1.00207332
121MP0003315_abnormal_perineum_morphology0.99967361
122MP0001533_abnormal_skeleton_physiology0.99459075
123MP0000653_abnormal_sex_gland0.99198650
124MP0005386_behavior/neurological_phenoty0.98119458
125MP0004924_abnormal_behavior0.98119458
126MP0000490_abnormal_crypts_of0.97331771
127MP0003646_muscle_fatigue0.97032743
128MP0009643_abnormal_urine_homeostasis0.96744600
129MP0001119_abnormal_female_reproductive0.95519577
130MP0005084_abnormal_gallbladder_morpholo0.95133805
131MP0002063_abnormal_learning/memory/cond0.94339597
132MP0008057_abnormal_DNA_replication0.93773142
133MP0002233_abnormal_nose_morphology0.93297936
134MP0003077_abnormal_cell_cycle0.92188178
135MP0003186_abnormal_redox_activity0.91533791
136MP0002751_abnormal_autonomic_nervous0.91531083
137MP0005253_abnormal_eye_physiology0.91391361
138MP0005166_decreased_susceptibility_to0.90795568
139MP0004811_abnormal_neuron_physiology0.90483282
140MP0001145_abnormal_male_reproductive0.90479127
141MP0003303_peritoneal_inflammation0.90425258
142MP0001486_abnormal_startle_reflex0.89980355
143MP0005083_abnormal_biliary_tract0.89686528
144MP0000569_abnormal_digit_pigmentation0.89405238
145MP0003937_abnormal_limbs/digits/tail_de0.89287207
146MP0000516_abnormal_urinary_system0.88939551
147MP0005367_renal/urinary_system_phenotyp0.88939551
148MP0000604_amyloidosis0.86452299
149MP0002067_abnormal_sensory_capabilities0.86322352
150MP0005410_abnormal_fertilization0.85704210
151MP0000343_altered_response_to0.85624063
152MP0008469_abnormal_protein_level0.85566687
153MP0003191_abnormal_cellular_cholesterol0.85293485
154MP0008004_abnormal_stomach_pH0.85285529
155MP0002723_abnormal_immune_serum0.85221548
156MP0002136_abnormal_kidney_physiology0.85208968
157MP0003075_altered_response_to0.84820487
158MP0002796_impaired_skin_barrier0.84235494
159MP0000627_abnormal_mammary_gland0.83974392
160MP0002064_seizures0.83878565
161MP0001819_abnormal_immune_cell0.83569314
162MP0005423_abnormal_somatic_nervous0.82823295
163MP0009765_abnormal_xenobiotic_induced0.82791576
164MP0005085_abnormal_gallbladder_physiolo0.82774004
165MP0004885_abnormal_endolymph0.82624818
166MP0000955_abnormal_spinal_cord0.82449513
167MP0002733_abnormal_thermal_nociception0.82242001
168MP0002184_abnormal_innervation0.80691985
169MP0001970_abnormal_pain_threshold0.80056004
170MP0003195_calcinosis0.80018389
171MP0002420_abnormal_adaptive_immunity0.78517029
172MP0003699_abnormal_female_reproductive0.78225818
173MP0000477_abnormal_intestine_morphology0.78038951
174MP0002161_abnormal_fertility/fecundity0.77905612
175MP0009333_abnormal_splenocyte_physiolog0.77322617
176MP0000049_abnormal_middle_ear0.76933053
177MP0002229_neurodegeneration0.76832403
178MP0002102_abnormal_ear_morphology0.75781481
179MP0001800_abnormal_humoral_immune0.75430662
180MP0005164_abnormal_response_to0.73872216
181MP0000579_abnormal_nail_morphology0.72799793
182MP0003638_abnormal_response/metabolism_0.72630303
183MP0001348_abnormal_lacrimal_gland0.70885496
184MP0003011_delayed_dark_adaptation0.70593973
185MP0005376_homeostasis/metabolism_phenot0.70558768
186MP0004883_abnormal_blood_vessel0.70385562
187MP0005636_abnormal_mineral_homeostasis0.69781951
188MP0010678_abnormal_skin_adnexa0.68889106
189MP0003656_abnormal_erythrocyte_physiolo0.68322056

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.96878307
2Autoimmune thrombocytopenia (HP:0001973)5.30120145
3Recurrent abscess formation (HP:0002722)4.78294073
4Abnormality of glutamine family amino acid metabolism (HP:0010902)4.70832468
5Recurrent bacterial skin infections (HP:0005406)4.70184579
6Ileus (HP:0002595)4.62689713
7Pigmentary retinal degeneration (HP:0001146)4.53841163
8Recurrent gram-negative bacterial infections (HP:0005420)4.30821572
9Abnormality of proline metabolism (HP:0010907)4.20952194
10Hydroxyprolinuria (HP:0003080)4.20952194
11Gingivitis (HP:0000230)4.16671933
12Stomatitis (HP:0010280)4.01881167
13Malnutrition (HP:0004395)3.84627649
14Male infertility (HP:0003251)3.74542023
15Interstitial pulmonary disease (HP:0006530)3.74237769
16Abnormality of the labia minora (HP:0012880)3.69809490
17Double outlet right ventricle (HP:0001719)3.68144403
18Congenital malformation of the right heart (HP:0011723)3.68144403
19Recurrent fungal infections (HP:0002841)3.64196340
20Increased IgE level (HP:0003212)3.64090472
21Abnormality of macrophages (HP:0004311)3.61853613
22Cortical dysplasia (HP:0002539)3.54663823
23Acute necrotizing encephalopathy (HP:0006965)3.52347112
24Optic neuritis (HP:0100653)3.52109055
25Retrobulbar optic neuritis (HP:0100654)3.52109055
26Orchitis (HP:0100796)3.44548670
27Congenital stationary night blindness (HP:0007642)3.39847135
28Acute encephalopathy (HP:0006846)3.26953489
29Keratoconjunctivitis (HP:0001096)3.17916590
30Recurrent cutaneous fungal infections (HP:0011370)3.13777751
31Chronic mucocutaneous candidiasis (HP:0002728)3.13777751
32Recurrent skin infections (HP:0001581)3.11968024
33Abnormal mitochondria in muscle tissue (HP:0008316)3.10814128
34Xerostomia (HP:0000217)3.01692601
35Right ventricular cardiomyopathy (HP:0011663)2.99443045
36Progressive macrocephaly (HP:0004481)2.96954957
37Myositis (HP:0100614)2.94108275
38Chronic diarrhea (HP:0002028)2.87965852
39Acanthocytosis (HP:0001927)2.85036609
40Facial shape deformation (HP:0011334)2.83866897
41Potter facies (HP:0002009)2.83866897
42Autoimmune hemolytic anemia (HP:0001890)2.81191980
43Abnormality of small intestinal villus morphology (HP:0011472)2.79227157
44Villous atrophy (HP:0011473)2.79227157
45Pustule (HP:0200039)2.78194640
46Mitochondrial inheritance (HP:0001427)2.75193790
47Mediastinal lymphadenopathy (HP:0100721)2.70521396
48Prostate neoplasm (HP:0100787)2.70066092
49Hypoglycemic coma (HP:0001325)2.69085956
50Myokymia (HP:0002411)2.65741745
51Combined immunodeficiency (HP:0005387)2.64500040
52Increased hepatocellular lipid droplets (HP:0006565)2.61526020
53Increased CSF lactate (HP:0002490)2.56957481
54Hypothermia (HP:0002045)2.54703977
55Widely patent fontanelles and sutures (HP:0004492)2.54427463
56Colon cancer (HP:0003003)2.51078394
57Hypobetalipoproteinemia (HP:0003563)2.50890576
58Hepatic necrosis (HP:0002605)2.48405649
59Renal Fanconi syndrome (HP:0001994)2.47452863
60Lipid accumulation in hepatocytes (HP:0006561)2.44505876
61Limb dystonia (HP:0002451)2.44118359
62Chronic obstructive pulmonary disease (HP:0006510)2.41766004
63Obstructive lung disease (HP:0006536)2.41766004
64Hyperglycinemia (HP:0002154)2.41665515
65Medial flaring of the eyebrow (HP:0010747)2.41280936
66Methylmalonic acidemia (HP:0002912)2.41239583
67Abnormality of purine metabolism (HP:0004352)2.37728131
68Dehydration (HP:0001944)2.37316974
69Pulmonary infiltrates (HP:0002113)2.33283593
70Urticaria (HP:0001025)2.32393592
71Abnormality of chloride homeostasis (HP:0011422)2.31837996
72Poor suck (HP:0002033)2.31322439
73Fat malabsorption (HP:0002630)2.30894970
74Cerebral edema (HP:0002181)2.27528310
75Gait imbalance (HP:0002141)2.27253976
76Thyroiditis (HP:0100646)2.26588444
77Cupped ribs (HP:0000887)2.25092093
78Hepatocellular necrosis (HP:0001404)2.23912522
79Hyperactive renin-angiotensin system (HP:0000841)2.23534461
80Failure to thrive in infancy (HP:0001531)2.21850498
81Hyperinsulinemic hypoglycemia (HP:0000825)2.20829768
82Polyphagia (HP:0002591)2.20101721
83Chorioretinal atrophy (HP:0000533)2.19623183
84Congenital primary aphakia (HP:0007707)2.16921417
85Severe combined immunodeficiency (HP:0004430)2.16324285
86Encephalitis (HP:0002383)2.14941679
87Nephrogenic diabetes insipidus (HP:0009806)2.13438143
88Congenital sensorineural hearing impairment (HP:0008527)2.13215240
89Abnormality of the gastric mucosa (HP:0004295)2.12070660
90Goiter (HP:0000853)2.10324465
913-Methylglutaconic aciduria (HP:0003535)2.09885382
92Methylmalonic aciduria (HP:0012120)2.09691076
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09165244
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09165244
95Papillary thyroid carcinoma (HP:0002895)2.08857481
96Pili torti (HP:0003777)2.08208203
97Degeneration of anterior horn cells (HP:0002398)2.06498487
98Abnormality of the anterior horn cell (HP:0006802)2.06498487
99Genital tract atresia (HP:0001827)2.03591967
100Tetany (HP:0001281)2.03440343
101Tetraparesis (HP:0002273)2.02808068
102Nausea (HP:0002018)2.00389047
103Keratoconjunctivitis sicca (HP:0001097)1.99741647
104Hyperglycinuria (HP:0003108)1.98899716
105Lissencephaly (HP:0001339)1.98853028
106Disinhibition (HP:0000734)1.98533615
107Abnormality of eosinophils (HP:0001879)1.97718428
108Hematochezia (HP:0002573)1.97174229
109Rectal prolapse (HP:0002035)1.95661923
110Labial hypoplasia (HP:0000066)1.94971361
111Pulmonary fibrosis (HP:0002206)1.94498907
112Recurrent pneumonia (HP:0006532)1.94091157
113Vaginal atresia (HP:0000148)1.94027327
114Hypsarrhythmia (HP:0002521)1.93754306
115Eosinophilia (HP:0001880)1.93678309
116Curly hair (HP:0002212)1.92099717
117Hypoplastic female external genitalia (HP:0012815)1.91053923
118Generalized aminoaciduria (HP:0002909)1.90671900
119Arterial tortuosity (HP:0005116)1.90131750
120Upper limb muscle weakness (HP:0003484)1.89892415
121Birth length less than 3rd percentile (HP:0003561)1.88839627
122Proximal tubulopathy (HP:0000114)1.88223561
123Leukocytosis (HP:0001974)1.87866611
124Abnormal hair whorl (HP:0010721)1.87509744
125Hypoglycemic seizures (HP:0002173)1.86546307
126Lactic acidosis (HP:0003128)1.86021144
127Abnormality of glycine metabolism (HP:0010895)1.85647312
128Abnormality of serine family amino acid metabolism (HP:0010894)1.85647312
129Gout (HP:0001997)1.85643459
130Ketoacidosis (HP:0001993)1.85247032
131Lip pit (HP:0100267)1.85015028
132EEG with generalized epileptiform discharges (HP:0011198)1.84557018
133Glycosuria (HP:0003076)1.83375876
134Abnormality of urine glucose concentration (HP:0011016)1.83375876
135Abnormality of homocysteine metabolism (HP:0010919)1.80650001
136Homocystinuria (HP:0002156)1.80650001
137Premature ovarian failure (HP:0008209)1.80649625
138Increased serum lactate (HP:0002151)1.80346609
139Epileptiform EEG discharges (HP:0011182)1.79968384
140Periodontitis (HP:0000704)1.77253826
141Conjugated hyperbilirubinemia (HP:0002908)1.77149029
142Abnormality of glycolysis (HP:0004366)1.76798629
143Vasculitis (HP:0002633)1.76096268
144Intestinal atresia (HP:0011100)1.74998796
145Pancreatic fibrosis (HP:0100732)1.74424910
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73941229
147Megaloblastic anemia (HP:0001889)1.72897836
148Optic nerve hypoplasia (HP:0000609)1.72196818
149Oligodactyly (hands) (HP:0001180)1.71568854
150Muscular hypotonia of the trunk (HP:0008936)1.71401853
151Molar tooth sign on MRI (HP:0002419)1.71387450
152Abnormality of midbrain morphology (HP:0002418)1.71387450
153Increased serum pyruvate (HP:0003542)1.71300683
154Progressive visual loss (HP:0000529)1.71064010
155Lethargy (HP:0001254)1.70939342
156Recurrent viral infections (HP:0004429)1.70937749
157Prominent metopic ridge (HP:0005487)1.69928512
158Poikilocytosis (HP:0004447)1.69808107
159Spastic tetraplegia (HP:0002510)1.69120309
160Septo-optic dysplasia (HP:0100842)1.68976385
161Increased purine levels (HP:0004368)1.68497186
162Hyperuricemia (HP:0002149)1.68497186
163Hypomagnesemia (HP:0002917)1.68200782
164Shawl scrotum (HP:0000049)1.68176208
165Abnormal glucose tolerance (HP:0001952)1.67634050
166Abnormality of serum amino acid levels (HP:0003112)1.67357121
167Pancreatic cysts (HP:0001737)1.67012029
168Abnormality of renal resorption (HP:0011038)1.66582775
169Breast hypoplasia (HP:0003187)1.66459146
170Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66268243
171Cheilitis (HP:0100825)1.66029770
172Hypoalbuminemia (HP:0003073)1.65137943
173Abnormal albumin level (HP:0012116)1.65137943
174Infertility (HP:0000789)1.65107052
175Abnormality of methionine metabolism (HP:0010901)1.65059400
176Poor coordination (HP:0002370)1.64998609
177Abnormality of the labia (HP:0000058)1.64683998
178Pancreatic islet-cell hyperplasia (HP:0004510)1.64661402
179X-linked dominant inheritance (HP:0001423)1.64191221
180Abnormality of sulfur amino acid metabolism (HP:0004339)1.64190235
181Renal cortical cysts (HP:0000803)1.64113421
182Broad-based gait (HP:0002136)1.63326522
183Pendular nystagmus (HP:0012043)1.60638474
184Thyroid carcinoma (HP:0002890)1.59437080
185Decreased testicular size (HP:0008734)1.58694367
186Scrotal hypoplasia (HP:0000046)1.58393033
187Abnormality of vitamin B metabolism (HP:0004340)1.58097049
188Meckel diverticulum (HP:0002245)1.57181419
189Abnormality of the metopic suture (HP:0005556)1.57033718
190Abnormality of alanine metabolism (HP:0010916)1.56671215
191Hyperalaninemia (HP:0003348)1.56671215
192Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56671215
193Cholecystitis (HP:0001082)1.56614047
194Abnormal gallbladder physiology (HP:0012438)1.56614047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.89278948
2MST43.58839370
3EPHA33.43413697
4MAP3K42.89153746
5LATS12.73035536
6BUB12.72862146
7TRIM282.62891354
8MAP3K142.60128402
9KSR22.55704452
10IRAK42.50200783
11EIF2AK12.44830314
12STK162.43300150
13SRPK12.37476691
14TAOK32.35716369
15MAP2K72.34845437
16TNIK2.24708840
17LMTK22.22174316
18MAP3K62.18234983
19PBK2.13748159
20ERBB42.12161005
21MAP3K92.08479155
22TSSK62.04894272
23ZAK2.03649571
24MAP4K21.96645054
25EPHB11.90826853
26PLK31.90020259
27STK101.82362118
28MST1R1.82243002
29CASK1.78709388
30BMPR21.78588731
31IRAK31.77378538
32NLK1.77269712
33MARK11.74849720
34RAF11.73603014
35BRAF1.70498469
36TBK11.70022079
37CDC71.69526430
38MELK1.67525584
39PRKCI1.65522501
40LATS21.65110091
41NUAK11.58788193
42CSNK1G31.57567385
43STK38L1.56840724
44MAP3K131.52698229
45CSNK1G11.52340069
46ARAF1.50949794
47CSNK1G21.50571629
48AKT31.49471755
49RIPK41.44064241
50BMPR1B1.41543474
51MAP3K121.41515951
52KSR11.41506059
53PRKG21.40919529
54PINK11.38560292
55VRK11.32750182
56TAOK11.32168541
57CSNK1A1L1.28005895
58TTK1.27627236
59IKBKE1.27097812
60EIF2AK31.25405723
61VRK21.22515400
62TYK21.22228956
63NME11.21835100
64MKNK21.21794904
65RPS6KA41.19820891
66MAP2K21.18502856
67MINK11.17513013
68DYRK21.15933556
69MKNK11.15021511
70ERN11.13703194
71TAF11.13197432
72PNCK1.12846578
73PLK21.08692056
74PTK61.05535818
75NTRK31.05493833
76ACVR1B1.04524562
77GRK61.03470359
78NEK11.00682245
79PRKCG0.97848398
80FGR0.95790454
81JAK30.95286783
82PRKAA20.94075477
83PASK0.91982074
84BCKDK0.91633168
85CDK190.91253585
86BCR0.90287128
87MOS0.88980494
88LRRK20.88943700
89ERBB30.88582992
90CHUK0.88397009
91MAP3K20.85559599
92BLK0.83659927
93CSNK1E0.81213050
94EPHA20.80927806
95TLK10.80220382
96STK30.80103299
97PHKG20.79915492
98PHKG10.79915492
99MAP2K40.79495442
100BRSK20.78024181
101EEF2K0.76807233
102WNK40.75819608
103ADRBK20.74071366
104PAK30.72436028
105UHMK10.72341645
106CCNB10.71933312
107OXSR10.69717586
108CAMK1G0.69155606
109AURKA0.67694090
110IKBKB0.67570534
111CDK30.64833262
112CDK90.64784833
113RPS6KA50.62105622
114ATM0.61402430
115JAK20.59943484
116DYRK30.59513083
117MAP3K10.58469613
118TESK10.57253409
119INSRR0.57139911
120PRKCE0.56627914
121TRPM70.56437389
122MAP3K80.56137182
123CAMK1D0.56062447
124MAP3K110.55563846
125CDK140.55278217
126DYRK1A0.54995771
127PRKAA10.54853073
128ABL20.54827564
129ATR0.54101535
130MUSK0.54052255
131PAK60.53993378
132BRSK10.53941583
133PTK20.53248651
134PIM20.51306725
135MAPKAPK30.50342979
136MATK0.50042678
137CSNK1A10.49180662
138SGK2230.49027467
139SGK4940.49027467
140CSNK2A20.48744310
141WNK30.48621307
142CDK50.47531353
143PLK10.46875920
144EPHB20.46464131
145AURKB0.45718031
146CDK180.45633987
147PDK20.45626923
148PRKCD0.45359497
149DAPK20.44506477
150CSNK2A10.44470540
151WEE10.44238597
152CAMK2A0.44193697
153MAP3K50.42791564
154TIE10.41615329
155GRK10.39158443
156CHEK20.37970468
157PLK40.36627729
158STK240.34653468
159MAPK130.32983133
160MET0.32301115
161MARK30.31725184
162SCYL20.31468829
163STK110.31185472
164PRKCZ0.31081434
165TEC0.30028187
166RIPK10.28979219
167PIM10.26367294
168ERBB20.26054863
169CDK80.25619655
170MAP2K10.25469364

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.33258230
2Mineral absorption_Homo sapiens_hsa049783.93480027
3Vitamin digestion and absorption_Homo sapiens_hsa049773.91296945
4Renin-angiotensin system_Homo sapiens_hsa046143.15094136
5Oxidative phosphorylation_Homo sapiens_hsa001903.15064195
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.94321519
7Parkinsons disease_Homo sapiens_hsa050122.71527081
8Caffeine metabolism_Homo sapiens_hsa002322.56919947
9Protein export_Homo sapiens_hsa030602.48989984
10Proteasome_Homo sapiens_hsa030502.30625661
11Mismatch repair_Homo sapiens_hsa034302.22328612
12RNA polymerase_Homo sapiens_hsa030202.12995291
13Leishmaniasis_Homo sapiens_hsa051402.12774674
14Galactose metabolism_Homo sapiens_hsa000522.04580853
15Basal transcription factors_Homo sapiens_hsa030222.02860348
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99595120
17Huntingtons disease_Homo sapiens_hsa050161.97407816
18Asthma_Homo sapiens_hsa053101.94167337
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88862255
20Phototransduction_Homo sapiens_hsa047441.88689648
21Histidine metabolism_Homo sapiens_hsa003401.86276010
22Steroid biosynthesis_Homo sapiens_hsa001001.85426678
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82438364
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.78939600
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77286863
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71973185
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70601489
28Sphingolipid metabolism_Homo sapiens_hsa006001.70003610
29Nicotine addiction_Homo sapiens_hsa050331.67367184
30Alzheimers disease_Homo sapiens_hsa050101.66648538
31Homologous recombination_Homo sapiens_hsa034401.61594968
32Protein digestion and absorption_Homo sapiens_hsa049741.55028892
33Propanoate metabolism_Homo sapiens_hsa006401.54696281
34Fatty acid elongation_Homo sapiens_hsa000621.53767607
35Rheumatoid arthritis_Homo sapiens_hsa053231.53000826
36Non-homologous end-joining_Homo sapiens_hsa034501.52654192
37Butanoate metabolism_Homo sapiens_hsa006501.50496495
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50317452
39Legionellosis_Homo sapiens_hsa051341.49974795
40Starch and sucrose metabolism_Homo sapiens_hsa005001.49974473
41Graft-versus-host disease_Homo sapiens_hsa053321.49727395
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49346581
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.49288255
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.48435147
45Ribosome_Homo sapiens_hsa030101.47966313
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45180197
47RNA transport_Homo sapiens_hsa030131.45057270
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42102586
49Folate biosynthesis_Homo sapiens_hsa007901.40139313
50Pyruvate metabolism_Homo sapiens_hsa006201.38190211
51RNA degradation_Homo sapiens_hsa030181.37913007
52DNA replication_Homo sapiens_hsa030301.36924157
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36833227
54Cardiac muscle contraction_Homo sapiens_hsa042601.34103125
55Fanconi anemia pathway_Homo sapiens_hsa034601.32626810
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31946911
57Tuberculosis_Homo sapiens_hsa051521.29027363
58One carbon pool by folate_Homo sapiens_hsa006701.27904296
59Selenocompound metabolism_Homo sapiens_hsa004501.23582508
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22770010
61Dorso-ventral axis formation_Homo sapiens_hsa043201.22605905
62TNF signaling pathway_Homo sapiens_hsa046681.20990465
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20420358
64Base excision repair_Homo sapiens_hsa034101.19573706
65Allograft rejection_Homo sapiens_hsa053301.17791798
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17728340
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17209258
68Nucleotide excision repair_Homo sapiens_hsa034201.16228054
69Synaptic vesicle cycle_Homo sapiens_hsa047211.12306330
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12219826
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10366012
72Spliceosome_Homo sapiens_hsa030401.08475238
73Salmonella infection_Homo sapiens_hsa051321.08032205
74Pancreatic cancer_Homo sapiens_hsa052121.08020448
75Pertussis_Homo sapiens_hsa051331.07604108
76Oocyte meiosis_Homo sapiens_hsa041141.06691704
77Staphylococcus aureus infection_Homo sapiens_hsa051501.06434729
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06230396
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.05562156
80African trypanosomiasis_Homo sapiens_hsa051431.04327281
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02828543
82Purine metabolism_Homo sapiens_hsa002301.02326035
83GABAergic synapse_Homo sapiens_hsa047271.00587614
84Vitamin B6 metabolism_Homo sapiens_hsa007500.98773227
85Osteoclast differentiation_Homo sapiens_hsa043800.97730044
86Influenza A_Homo sapiens_hsa051640.93677814
87Pyrimidine metabolism_Homo sapiens_hsa002400.93602887
88Cell cycle_Homo sapiens_hsa041100.92086990
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92053857
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89084896
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88525001
92Glutathione metabolism_Homo sapiens_hsa004800.88437491
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86603780
94Ether lipid metabolism_Homo sapiens_hsa005650.86423014
95Bile secretion_Homo sapiens_hsa049760.86252715
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85871320
97mRNA surveillance pathway_Homo sapiens_hsa030150.84748336
98Chemokine signaling pathway_Homo sapiens_hsa040620.83929874
99Prolactin signaling pathway_Homo sapiens_hsa049170.82914451
100Taste transduction_Homo sapiens_hsa047420.82476192
101Sulfur metabolism_Homo sapiens_hsa009200.81793205
102* Metabolic pathways_Homo sapiens_hsa011000.81697393
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.81475434
104Glycerolipid metabolism_Homo sapiens_hsa005610.80915223
105Regulation of autophagy_Homo sapiens_hsa041400.80631896
106Autoimmune thyroid disease_Homo sapiens_hsa053200.80555104
107Toxoplasmosis_Homo sapiens_hsa051450.80490376
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78516357
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78228794
110Type I diabetes mellitus_Homo sapiens_hsa049400.78068855
111Linoleic acid metabolism_Homo sapiens_hsa005910.77761977
112Fatty acid biosynthesis_Homo sapiens_hsa000610.76965641
113Fructose and mannose metabolism_Homo sapiens_hsa000510.76784897
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75076857
115Hematopoietic cell lineage_Homo sapiens_hsa046400.75060982
116Pentose phosphate pathway_Homo sapiens_hsa000300.74592895
117Collecting duct acid secretion_Homo sapiens_hsa049660.73858272
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.72777100
119Peroxisome_Homo sapiens_hsa041460.72740166
120Apoptosis_Homo sapiens_hsa042100.72063655
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72011088
122Dopaminergic synapse_Homo sapiens_hsa047280.71853990
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.71722084
124Malaria_Homo sapiens_hsa051440.71554506
125Ovarian steroidogenesis_Homo sapiens_hsa049130.70913979
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70036537
127* Arginine and proline metabolism_Homo sapiens_hsa003300.68995456
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68970675
129Arachidonic acid metabolism_Homo sapiens_hsa005900.68865921
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68460399
131beta-Alanine metabolism_Homo sapiens_hsa004100.68369831
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67972776
133Hepatitis C_Homo sapiens_hsa051600.67862473
134Other glycan degradation_Homo sapiens_hsa005110.67558011
135Phagosome_Homo sapiens_hsa041450.67537536
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67468085
137* Biosynthesis of amino acids_Homo sapiens_hsa012300.67121349
138Serotonergic synapse_Homo sapiens_hsa047260.65349041
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65144364
140Vibrio cholerae infection_Homo sapiens_hsa051100.64868813
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64838767
142Carbon metabolism_Homo sapiens_hsa012000.64074197
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63771292
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62538210
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.62483125
146Fatty acid metabolism_Homo sapiens_hsa012120.61892784
147Morphine addiction_Homo sapiens_hsa050320.60731513
148Tryptophan metabolism_Homo sapiens_hsa003800.60269100
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59167854
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58237051
151Insulin secretion_Homo sapiens_hsa049110.57742921
152Hepatitis B_Homo sapiens_hsa051610.57001978
153Olfactory transduction_Homo sapiens_hsa047400.56390503
154Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54537360
155Bladder cancer_Homo sapiens_hsa052190.54470011
156Cocaine addiction_Homo sapiens_hsa050300.53790074
157Shigellosis_Homo sapiens_hsa051310.52670723
158Glutamatergic synapse_Homo sapiens_hsa047240.51753035
159Sulfur relay system_Homo sapiens_hsa041220.51595740
160PPAR signaling pathway_Homo sapiens_hsa033200.51159941
161Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49003512
162Long-term depression_Homo sapiens_hsa047300.47814944
163p53 signaling pathway_Homo sapiens_hsa041150.47741941
164TGF-beta signaling pathway_Homo sapiens_hsa043500.47408503
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47345001
166Amphetamine addiction_Homo sapiens_hsa050310.46631242
167Choline metabolism in cancer_Homo sapiens_hsa052310.46119292
168Circadian entrainment_Homo sapiens_hsa047130.45013740
169VEGF signaling pathway_Homo sapiens_hsa043700.44471929
170MicroRNAs in cancer_Homo sapiens_hsa052060.42732876
171Inositol phosphate metabolism_Homo sapiens_hsa005620.41771840
172Adherens junction_Homo sapiens_hsa045200.40807481
173* Amoebiasis_Homo sapiens_hsa051460.33910920
174Circadian rhythm_Homo sapiens_hsa047100.32687027
175ABC transporters_Homo sapiens_hsa020100.32582384
176Sphingolipid signaling pathway_Homo sapiens_hsa040710.30313746
177Retinol metabolism_Homo sapiens_hsa008300.29129359
178FoxO signaling pathway_Homo sapiens_hsa040680.28784971
179Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28617900
180Chronic myeloid leukemia_Homo sapiens_hsa052200.28207987
181GnRH signaling pathway_Homo sapiens_hsa049120.26234986
182Thyroid hormone synthesis_Homo sapiens_hsa049180.25734494

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