ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of prostaglandin secretion (GO:0032308)	9.06840936
2	regulation of prostaglandin secretion (GO:0032306)	7.96694059
3	replicative senescence (GO:0090399)	7.43262614
4	negative regulation of catenin import into nucleus (GO:0035414)	6.75579295
5	regulation of endothelial cell differentiation (GO:0045601)	6.07276529
6	hematopoietic stem cell proliferation (GO:0071425)	5.74470835
7	DNA replication-dependent nucleosome assembly (GO:0006335)	5.69555205
8	DNA replication-dependent nucleosome organization (GO:0034723)	5.69555205
9	regulation of somitogenesis (GO:0014807)	5.67821317
10	positive regulation of icosanoid secretion (GO:0032305)	5.67266959
11	positive regulation of digestive system process (GO:0060456)	5.59974928
12	positive regulation of fatty acid transport (GO:2000193)	5.57259739
13	regulation of cardiac muscle cell contraction (GO:0086004)	5.47712097
14	detection of calcium ion (GO:0005513)	5.22470466
15	epithelial cell differentiation involved in kidney development (GO:0035850)	5.20704483
16	tryptophan metabolic process (GO:0006568)	5.17882700
17	positive regulation of cAMP-mediated signaling (GO:0043950)	5.11861331
18	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	5.01288357
19	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.68427932
20	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.64604958
21	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.64604958
22	pyrimidine nucleobase catabolic process (GO:0006208)	4.62128013
23	positive regulation of cardiac muscle cell differentiation (GO:2000727)	4.61799937
24	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	4.49319524
25	positive regulation of fatty acid biosynthetic process (GO:0045723)	4.44882100
26	release of cytochrome c from mitochondria (GO:0001836)	4.43411584
27	negative regulation of systemic arterial blood pressure (GO:0003085)	4.33601273
28	negative regulation of multicellular organism growth (GO:0040015)	4.27082207
29	primary amino compound metabolic process (GO:1901160)	4.23222533
30	neuronal action potential (GO:0019228)	4.21629363
31	indolalkylamine metabolic process (GO:0006586)	4.18059821
32	regulation of icosanoid secretion (GO:0032303)	4.17770731
33	regulation of actin filament-based movement (GO:1903115)	4.08731799
34	adrenergic receptor signaling pathway (GO:0071875)	4.07404484
35	serotonin metabolic process (GO:0042428)	3.93552390
36	cellular response to cholesterol (GO:0071397)	3.78362165
37	nucleobase catabolic process (GO:0046113)	3.76071381
38	negative regulation of peptidyl-lysine acetylation (GO:2000757)	3.73848167
39	acrosome reaction (GO:0007340)	3.68938052
40	positive regulation of organic acid transport (GO:0032892)	3.51825055
41	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.51200094
42	cellular response to sterol (GO:0036315)	3.41018857
43	DNA integration (GO:0015074)	3.40756887
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.39899074
45	NADH dehydrogenase complex assembly (GO:0010257)	3.39899074
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.39899074
47	axonal fasciculation (GO:0007413)	3.32727326
48	indole-containing compound catabolic process (GO:0042436)	3.28038376
49	indolalkylamine catabolic process (GO:0046218)	3.28038376
50	tryptophan catabolic process (GO:0006569)	3.28038376
51	negative regulation of mast cell activation (GO:0033004)	3.26007770
52	positive regulation of muscle hypertrophy (GO:0014742)	3.24478215
53	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.24478215
54	presynaptic membrane organization (GO:0097090)	3.17759434
55	tyrosine metabolic process (GO:0006570)	3.16754706
56	heparin metabolic process (GO:0030202)	3.13569434
57	heparin biosynthetic process (GO:0030210)	3.13569434
58	glycoprotein biosynthetic process (GO:0009101)	3.13543219
59	cardiac muscle adaptation (GO:0014887)	3.12594713
60	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.12594713
61	muscle hypertrophy in response to stress (GO:0003299)	3.12594713
62	indole-containing compound metabolic process (GO:0042430)	3.11761157
63	negative regulation of protein acetylation (GO:1901984)	3.10463769
64	presynaptic membrane assembly (GO:0097105)	3.10375284
65	postsynaptic membrane organization (GO:0001941)	3.01239119
66	positive regulation of heart rate (GO:0010460)	3.00570855
67	positive regulation of mitochondrial fission (GO:0090141)	2.93253436
68	C4-dicarboxylate transport (GO:0015740)	2.92630604
69	kynurenine metabolic process (GO:0070189)	2.91439054
70	response to auditory stimulus (GO:0010996)	2.89482998
71	regulation of cAMP-mediated signaling (GO:0043949)	2.88242421
72	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)	2.87114621
73	regulation of fatty acid transport (GO:2000191)	2.79616559
74	histone H2A monoubiquitination (GO:0035518)	2.78206956
75	behavioral response to nicotine (GO:0035095)	2.76492164
76	cytidine metabolic process (GO:0046087)	2.72686785
77	cytidine catabolic process (GO:0006216)	2.72686785
78	cytidine deamination (GO:0009972)	2.72686785
79	negative regulation of smooth muscle contraction (GO:0045986)	2.71138998
80	positive regulation of systemic arterial blood pressure (GO:0003084)	2.69922837
81	protein complex biogenesis (GO:0070271)	2.69137997
82	neuron recognition (GO:0008038)	2.68686438
83	auditory behavior (GO:0031223)	2.68141416
84	positive regulation of fatty acid metabolic process (GO:0045923)	2.66835691
85	negative regulation of gene silencing (GO:0060969)	2.62822171
86	molting cycle (GO:0042303)	2.62456984
87	hair cycle (GO:0042633)	2.62456984
88	cerebellar Purkinje cell differentiation (GO:0021702)	2.60721005
89	fear response (GO:0042596)	2.58774123
90	post-anal tail morphogenesis (GO:0036342)	2.58702586
91	positive regulation of cation channel activity (GO:2001259)	2.57413302
92	cell differentiation involved in kidney development (GO:0061005)	2.57292288
93	regulation of metalloenzyme activity (GO:0048552)	2.55485711
94	dendritic spine morphogenesis (GO:0060997)	2.52579345
95	neuron cell-cell adhesion (GO:0007158)	2.51413884
96	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.51091959
97	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.51039445
98	regulation of cardiac muscle cell differentiation (GO:2000725)	2.50530426
99	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.49722378
100	sensory perception of pain (GO:0019233)	2.48162855

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	6.22410721
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.27548134
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.05297554
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60771104
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55548800
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.52180161
7	TP53_16413492_ChIP-PET_HCT116_Human	2.29674052
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.21830342
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08078966
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.05100846
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	13.2379618
12	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.77072996
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76992095
14	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72591673
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68930115
16	AR_21572438_ChIP-Seq_LNCaP_Human	1.67000799
17	VDR_22108803_ChIP-Seq_LS180_Human	1.65159060
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.65077336
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64132870
20	FUS_26573619_Chip-Seq_HEK293_Human	1.55530796
21	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54465847
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53426385
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42311992
24	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36025387
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35668791
26	P300_19829295_ChIP-Seq_ESCs_Human	1.33140017
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.27914745
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27240294
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.26819425
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26676391
31	STAT3_23295773_ChIP-Seq_U87_Human	1.26194893
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26024142
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25720369
34	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.24374305
35	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22285977
36	AR_25329375_ChIP-Seq_VCAP_Human	1.18512504
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.18189482
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.17441145
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16264749
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16090201
41	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14038789
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12523960
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.09100482
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07202432
45	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07177543
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03414049
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.02573007
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02473442
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01875086
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01222872
51	EWS_26573619_Chip-Seq_HEK293_Human	1.01103841
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.00431494
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00283443
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99140557
55	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.98199601
56	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97347526
57	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97347526
58	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96743714
59	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96668201
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93066506
61	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.92763376
62	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.92669747
63	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.92017142
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.91810076
65	TP53_18474530_ChIP-ChIP_U2OS_Human	0.90657080
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90576057
67	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.89519513
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89288141
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88937084
70	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.88747152
71	RNF2_27304074_Chip-Seq_NSC_Mouse	0.88719931
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86489509
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.83523491
74	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83237589
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81316496
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.80237631
77	TCF4_23295773_ChIP-Seq_U87_Human	0.79512564
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.77936371
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77709550
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.77709550
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.77622950
82	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.76743208
83	ELK1_19687146_ChIP-ChIP_HELA_Human	0.76245244
84	SOX9_26525672_Chip-Seq_HEART_Mouse	0.74233943
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.73625353
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.72316308
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.72316308
88	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.71217065
89	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.71207768
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.70378689
91	MYC_18940864_ChIP-ChIP_HL60_Human	0.69958476
92	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.69666492
93	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.68072546
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.67972404
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.67496272
96	KDM2B_26808549_Chip-Seq_REH_Human	0.67323259
97	JUN_21703547_ChIP-Seq_K562_Human	0.66824218
98	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.66616283
99	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.65721157
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.65642747

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	4.77043913
2	MP0008872_abnormal_physiological_respon	4.48372507
3	MP0009764_decreased_sensitivity_to	3.28971767
4	MP0000372_irregular_coat_pigmentation	3.13822413
5	MP0005083_abnormal_biliary_tract	2.91679618
6	MP0002102_abnormal_ear_morphology	2.75265769
7	MP0009697_abnormal_copulation	2.50112971
8	MP0005503_abnormal_tendon_morphology	2.22656864
9	MP0003122_maternal_imprinting	2.21226355
10	MP0001984_abnormal_olfaction	2.20382165
11	MP0004859_abnormal_synaptic_plasticity	2.17501066
12	MP0002736_abnormal_nociception_after	2.09633029
13	MP0000778_abnormal_nervous_system	2.03684614
14	MP0000749_muscle_degeneration	2.03096600
15	MP0003221_abnormal_cardiomyocyte_apopto	1.99831260
16	MP0004270_analgesia	1.92654288
17	MP0006276_abnormal_autonomic_nervous	1.86441977
18	MP0003787_abnormal_imprinting	1.84578785
19	MP0002064_seizures	1.79303725
20	MP0005253_abnormal_eye_physiology	1.77313693
21	MP0003635_abnormal_synaptic_transmissio	1.76631440
22	MP0001968_abnormal_touch/_nociception	1.75405552
23	MP0002272_abnormal_nervous_system	1.74625212
24	MP0001529_abnormal_vocalization	1.73432256
25	MP0002735_abnormal_chemical_nociception	1.69624531
26	MP0003121_genomic_imprinting	1.67608754
27	MP0000569_abnormal_digit_pigmentation	1.63290863
28	MP0001502_abnormal_circadian_rhythm	1.62372170
29	MP0003880_abnormal_central_pattern	1.61567537
30	MP0005275_abnormal_skin_tensile	1.58041515
31	MP0002822_catalepsy	1.53530564
32	MP0004133_heterotaxia	1.52843121
33	MP0002733_abnormal_thermal_nociception	1.52482258
34	MP0005410_abnormal_fertilization	1.51694104
35	MP0006292_abnormal_olfactory_placode	1.50083352
36	MP0002734_abnormal_mechanical_nocicepti	1.47833240
37	MP0002876_abnormal_thyroid_physiology	1.46330875
38	MP0002638_abnormal_pupillary_reflex	1.43759314
39	MP0009745_abnormal_behavioral_response	1.40431489
40	MP0005084_abnormal_gallbladder_morpholo	1.39795401
41	MP0001970_abnormal_pain_threshold	1.39173379
42	MP0003195_calcinosis	1.38628370
43	MP0000747_muscle_weakness	1.35200391
44	MP0000631_abnormal_neuroendocrine_gland	1.34026379
45	MP0002163_abnormal_gland_morphology	1.33767450
46	MP0004811_abnormal_neuron_physiology	1.33342883
47	MP0009046_muscle_twitch	1.32273812
48	MP0005551_abnormal_eye_electrophysiolog	1.30189459
49	MP0003283_abnormal_digestive_organ	1.28824039
50	MP0004924_abnormal_behavior	1.28451062
51	MP0005386_behavior/neurological_phenoty	1.28451062
52	MP0006072_abnormal_retinal_apoptosis	1.27545242
53	MP0005423_abnormal_somatic_nervous	1.24871535
54	MP0002063_abnormal_learning/memory/cond	1.24346597
55	MP0002139_abnormal_hepatobiliary_system	1.23396348
56	MP0002653_abnormal_ependyma_morphology	1.21240311
57	MP0008770_decreased_survivor_rate	1.20401032
58	MP0008875_abnormal_xenobiotic_pharmacok	1.19513302
59	MP0010386_abnormal_urinary_bladder	1.13364753
60	MP0002909_abnormal_adrenal_gland	1.11154412
61	MP0002067_abnormal_sensory_capabilities	1.11129748
62	MP0002572_abnormal_emotion/affect_behav	1.10806378
63	MP0003011_delayed_dark_adaptation	1.10759675
64	MP0002837_dystrophic_cardiac_calcinosis	1.09619924
65	MP0003329_amyloid_beta_deposits	1.08558177
66	MP0004134_abnormal_chest_morphology	1.07340503
67	MP0002557_abnormal_social/conspecific_i	1.06982486
68	MP0009384_cardiac_valve_regurgitation	1.05961792
69	MP0002928_abnormal_bile_duct	1.05422329
70	MP0000371_diluted_coat_color	1.02529068
71	MP0002295_abnormal_pulmonary_circulatio	1.00357955
72	MP0001986_abnormal_taste_sensitivity	1.00340677
73	MP0002184_abnormal_innervation	0.99512245
74	MP0002882_abnormal_neuron_morphology	0.99495839
75	MP0000013_abnormal_adipose_tissue	0.98301459
76	MP0005379_endocrine/exocrine_gland_phen	0.97859475
77	MP0002269_muscular_atrophy	0.96642309
78	MP0001486_abnormal_startle_reflex	0.95638242
79	MP0002152_abnormal_brain_morphology	0.94428159
80	MP0000604_amyloidosis	0.93920699
81	MP0005645_abnormal_hypothalamus_physiol	0.93890240
82	MP0005195_abnormal_posterior_eye	0.92721008
83	MP0005584_abnormal_enzyme/coenzyme_acti	0.89793351
84	MP0003252_abnormal_bile_duct	0.89558814
85	MP0001905_abnormal_dopamine_level	0.86753728
86	MP0000955_abnormal_spinal_cord	0.86364850
87	MP0002752_abnormal_somatic_nervous	0.81654365
88	MP0000427_abnormal_hair_cycle	0.81207961
89	MP0003634_abnormal_glial_cell	0.78988245
90	MP0001764_abnormal_homeostasis	0.78594717
91	MP0005085_abnormal_gallbladder_physiolo	0.75245396
92	MP0003633_abnormal_nervous_system	0.73852974
93	MP0003186_abnormal_redox_activity	0.73306207
94	MP0004142_abnormal_muscle_tone	0.72593734
95	MP0008877_abnormal_DNA_methylation	0.70739619
96	MP0003861_abnormal_nervous_system	0.67106671
97	MP0002229_neurodegeneration	0.64738499
98	MP0003183_abnormal_peptide_metabolism	0.64164326
99	MP0008438_abnormal_cutaneous_collagen	0.63641448
100	MP0010770_preweaning_lethality	0.63542281

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oral leukoplakia (HP:0002745)	7.99368575
2	Cerebellar dysplasia (HP:0007033)	6.85135606
3	Type II lissencephaly (HP:0007260)	6.62529422
4	Calf muscle hypertrophy (HP:0008981)	5.88431683
5	Anomalous pulmonary venous return (HP:0010772)	5.69796085
6	Hemiplegia (HP:0002301)	5.43658200
7	Abnormality of the pulmonary veins (HP:0011718)	5.21716606
8	Muscle hypertrophy of the lower extremities (HP:0008968)	5.08557438
9	Hypoplasia of the pons (HP:0012110)	4.89647191
10	Abnormality of the pons (HP:0007361)	4.61631692
11	Hypothermia (HP:0002045)	4.28510994
12	Shoulder girdle muscle weakness (HP:0003547)	3.94172564
13	Limb-girdle muscle atrophy (HP:0003797)	3.91951301
14	Pelvic girdle muscle weakness (HP:0003749)	3.85479526
15	Abnormality of the musculature of the pelvis (HP:0001469)	3.77508596
16	Abnormality of the hip-girdle musculature (HP:0001445)	3.77508596
17	Frequent falls (HP:0002359)	3.66642158
18	Delayed gross motor development (HP:0002194)	3.54131694
19	Vertebral fusion (HP:0002948)	3.53608376
20	Death in childhood (HP:0003819)	3.42941048
21	Short femoral neck (HP:0100864)	3.28816522
22	Lissencephaly (HP:0001339)	3.22347427
23	Achilles tendon contracture (HP:0001771)	3.15236140
24	Drooling (HP:0002307)	3.09562281
25	Hemivertebrae (HP:0002937)	3.07034517
26	Severe muscular hypotonia (HP:0006829)	3.06381071
27	Abnormality of the Achilles tendon (HP:0005109)	3.03829549
28	Meningocele (HP:0002435)	3.02888157
29	Lipid accumulation in hepatocytes (HP:0006561)	3.00611737
30	Neoplasm of the heart (HP:0100544)	2.95708829
31	Difficulty climbing stairs (HP:0003551)	2.95559311
32	Short 4th metacarpal (HP:0010044)	2.92216570
33	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.92216570
34	Rough bone trabeculation (HP:0100670)	2.85413036
35	Morphological abnormality of the pyramidal tract (HP:0002062)	2.83986365
36	Spinal muscular atrophy (HP:0007269)	2.82269480
37	Excessive salivation (HP:0003781)	2.81902708
38	Hypoplasia of the brainstem (HP:0002365)	2.79968542
39	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.79968542
40	Pachygyria (HP:0001302)	2.77644220
41	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.75415683
42	Hyperventilation (HP:0002883)	2.65667249
43	Leukodystrophy (HP:0002415)	2.61506349
44	Increased hepatocellular lipid droplets (HP:0006565)	2.54608465
45	Upper motor neuron abnormality (HP:0002127)	2.54228220
46	Amelogenesis imperfecta (HP:0000705)	2.53654789
47	Premature graying of hair (HP:0002216)	2.47421314
48	Focal motor seizures (HP:0011153)	2.47318816
49	Hypoventilation (HP:0002791)	2.40947694
50	Abnormality of the odontoid process (HP:0003310)	2.40325752
51	Broad ribs (HP:0000885)	2.34197809
52	Abnormality of the intervertebral disk (HP:0005108)	2.33762515
53	Deformed sella turcica (HP:0002681)	2.26137973
54	Abnormality of the calf musculature (HP:0001430)	2.23154744
55	Hepatocellular necrosis (HP:0001404)	2.22271732
56	Myoglobinuria (HP:0002913)	2.20285594
57	Pathologic fracture (HP:0002756)	2.19707718
58	Redundant skin (HP:0001582)	2.13052670
59	Abnormality of the 4th metacarpal (HP:0010012)	2.12596204
60	Mitochondrial inheritance (HP:0001427)	2.09964495
61	Macroglossia (HP:0000158)	2.08958676
62	Medulloblastoma (HP:0002885)	2.07882245
63	Postural tremor (HP:0002174)	2.06741640
64	Aplasia/hypoplasia of the femur (HP:0005613)	2.06535785
65	Arterial tortuosity (HP:0005116)	2.05734299
66	Abnormal trabecular bone morphology (HP:0100671)	2.03920339
67	Myelomeningocele (HP:0002475)	2.03630100
68	Pancreatic cysts (HP:0001737)	2.00254895
69	Proximal amyotrophy (HP:0007126)	1.97409858
70	Down-sloping shoulders (HP:0200021)	1.96680153
71	Increased CSF lactate (HP:0002490)	1.96238964
72	CNS hypomyelination (HP:0003429)	1.95208850
73	Abnormality of the renal cortex (HP:0011035)	1.94706296
74	Cellular immunodeficiency (HP:0005374)	1.94375381
75	Neoplasm of the oral cavity (HP:0100649)	1.93101333
76	Renal Fanconi syndrome (HP:0001994)	1.92275718
77	Nephronophthisis (HP:0000090)	1.90808697
78	Vascular tortuosity (HP:0004948)	1.87910549
79	Hepatic necrosis (HP:0002605)	1.87560219
80	Hyperglycinemia (HP:0002154)	1.87158586
81	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.86471614
82	Posterior subcapsular cataract (HP:0007787)	1.85470232
83	Pendular nystagmus (HP:0012043)	1.84919110
84	Abnormality of the vitreous humor (HP:0004327)	1.81087098
85	Late onset (HP:0003584)	1.79891003
86	Agitation (HP:0000713)	1.79737584
87	Intellectual disability, profound (HP:0002187)	1.79466042
88	Glycosuria (HP:0003076)	1.78904648
89	Abnormality of urine glucose concentration (HP:0011016)	1.78904648
90	Abnormality of midbrain morphology (HP:0002418)	1.73487278
91	Molar tooth sign on MRI (HP:0002419)	1.73487278
92	Vertebral arch anomaly (HP:0008438)	1.67114480
93	Limb-girdle muscle weakness (HP:0003325)	1.66912717
94	Broad-based gait (HP:0002136)	1.66656497
95	Carpal bone hypoplasia (HP:0001498)	1.62410035
96	Prominent occiput (HP:0000269)	1.60426180
97	Focal seizures (HP:0007359)	1.59083631
98	Oligodontia (HP:0000677)	1.59042789
99	Abnormality of salivation (HP:0100755)	1.58543154
100	Increased corneal curvature (HP:0100692)	1.58018227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	8.34167630
2	MAP2K7	8.04057261
3	MAP2K4	4.97246992
4	ZAK	4.42430817
5	TLK1	3.77698638
6	EPHA3	2.50510691
7	CASK	2.49457054
8	BLK	2.12508097
9	VRK1	2.11378295
10	MARK1	1.79709647
11	MAP4K2	1.71121865
12	RET	1.62924807
13	ADRBK2	1.58479939
14	FRK	1.48865204
15	MAPK13	1.38895382
16	PDK2	1.09181241
17	PKN1	1.07809215
18	CSNK1G2	1.07573939
19	LATS1	1.06261360
20	PRKCI	1.03854924
21	EEF2K	0.92346845
22	NTRK3	0.92160444
23	CSNK1G3	0.90734794
24	ERBB3	0.90734574
25	NUAK1	0.89918956
26	CSNK1A1L	0.89481100
27	CSNK1G1	0.89130395
28	TNIK	0.87281618
29	RPS6KA5	0.87074358
30	NTRK2	0.83994492
31	MAPKAPK3	0.81100766
32	GRK1	0.76542986
33	PTK2B	0.75546681
34	PRKCH	0.70378825
35	DYRK2	0.69917010
36	EIF2AK3	0.66706176
37	TAF1	0.64455707
38	WNK3	0.63755395
39	PRKCG	0.63437830
40	BMPR1B	0.61552651
41	DAPK3	0.61431610
42	STK4	0.60155861
43	PRKAA1	0.59035991
44	MAP2K6	0.57009059
45	TRIM28	0.56886669
46	PLK2	0.56594222
47	AURKA	0.54009316
48	PAK3	0.53106935
49	PRKCE	0.52017086
50	CAMKK2	0.51801751
51	PINK1	0.50819675
52	TAOK3	0.48871940
53	BRSK2	0.47451474
54	PAK6	0.47224468
55	BCR	0.46145651
56	SIK2	0.45989477
57	PHKG2	0.43687482
58	PHKG1	0.43687482
59	DAPK2	0.43077565
60	LMTK2	0.38569871
61	PIM1	0.34783068
62	PRKCQ	0.34243972
63	CCNB1	0.31064500
64	BRSK1	0.30822897
65	ADRBK1	0.30797295
66	MAPK11	0.29277691
67	MAPKAPK5	0.27745306
68	PRKCZ	0.27477968
69	GRK5	0.25857682
70	ACVR1B	0.23049272
71	SGK2	0.21566551
72	LATS2	0.20676400
73	STK39	0.19690242
74	CAMK4	0.18933332
75	SGK494	0.17860469
76	SGK223	0.17860469
77	NEK6	0.17455989
78	NTRK1	0.17409044
79	CHEK2	0.16966613
80	MKNK2	0.16525657
81	FER	0.16342661
82	WNK4	0.14599124
83	MAP2K3	0.14533801
84	HIPK2	0.14138738
85	ROCK1	0.13366179
86	CAMK2A	0.13239790
87	DYRK1A	0.12332583
88	CDK5	0.11479004
89	TRPM7	0.10995217
90	STK38L	0.10974507
91	CAMK1D	0.10226442
92	PRKACA	0.10017295
93	CSNK1A1	0.09659715
94	CSNK1D	0.09438162
95	BUB1	0.09188969
96	MAPK12	0.09014477
97	ATR	0.08297409
98	PRKCA	0.07354533
99	MAPK9	0.07296782
100	PLK1	0.06648653

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	6.33894589
2	Alcoholism_Homo sapiens_hsa05034	4.99715886
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.13308031
4	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.38437286
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.23885461
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98476612
7	Tryptophan metabolism_Homo sapiens_hsa00380	1.96858433
8	Insulin secretion_Homo sapiens_hsa04911	1.87728626
9	Sulfur metabolism_Homo sapiens_hsa00920	1.79216444
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74831162
11	Butanoate metabolism_Homo sapiens_hsa00650	1.72572295
12	Nicotine addiction_Homo sapiens_hsa05033	1.70386886
13	Dopaminergic synapse_Homo sapiens_hsa04728	1.58370165
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56018198
15	Morphine addiction_Homo sapiens_hsa05032	1.49733697
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49684096
17	Viral carcinogenesis_Homo sapiens_hsa05203	1.44104671
18	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.42058059
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38225944
20	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.37134931
21	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.29146890
22	RNA polymerase_Homo sapiens_hsa03020	1.27267375
23	Phototransduction_Homo sapiens_hsa04744	1.23208215
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22761871
25	Type II diabetes mellitus_Homo sapiens_hsa04930	1.22049451
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.21874867
27	Circadian entrainment_Homo sapiens_hsa04713	1.20445592
28	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.15349921
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.12440073
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.10090589
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.08383440
32	GABAergic synapse_Homo sapiens_hsa04727	1.06950342
33	Salivary secretion_Homo sapiens_hsa04970	1.06288541
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.02547561
35	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.01635638
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98680350
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96486054
38	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.94555947
39	Colorectal cancer_Homo sapiens_hsa05210	0.93055264
40	Olfactory transduction_Homo sapiens_hsa04740	0.89457562
41	cAMP signaling pathway_Homo sapiens_hsa04024	0.87139579
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85087747
43	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.82910008
44	Histidine metabolism_Homo sapiens_hsa00340	0.81376604
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81169772
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.79767563
47	Prolactin signaling pathway_Homo sapiens_hsa04917	0.79525783
48	Glutathione metabolism_Homo sapiens_hsa00480	0.79350736
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78955207
50	Renin secretion_Homo sapiens_hsa04924	0.78716477
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.75881823
52	Gap junction_Homo sapiens_hsa04540	0.75282147
53	Parkinsons disease_Homo sapiens_hsa05012	0.75236705
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74396626
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73399997
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73167175
57	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.72329021
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.71200810
59	ErbB signaling pathway_Homo sapiens_hsa04012	0.69200173
60	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.68146623
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.67065188
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64532516
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.64480632
64	Cholinergic synapse_Homo sapiens_hsa04725	0.64214874
65	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.63873736
66	Regulation of autophagy_Homo sapiens_hsa04140	0.62805518
67	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.60977148
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.60023580
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59572152
70	Peroxisome_Homo sapiens_hsa04146	0.57029481
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.56116571
72	Cocaine addiction_Homo sapiens_hsa05030	0.55027633
73	ABC transporters_Homo sapiens_hsa02010	0.54995623
74	Axon guidance_Homo sapiens_hsa04360	0.54728440
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.54504221
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54405634
77	Alzheimers disease_Homo sapiens_hsa05010	0.53241342
78	GnRH signaling pathway_Homo sapiens_hsa04912	0.52279353
79	Homologous recombination_Homo sapiens_hsa03440	0.51927201
80	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51595402
81	Oocyte meiosis_Homo sapiens_hsa04114	0.50751751
82	Lysosome_Homo sapiens_hsa04142	0.49343192
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47703979
84	Pancreatic secretion_Homo sapiens_hsa04972	0.46932345
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.46293152
86	Huntingtons disease_Homo sapiens_hsa05016	0.44700011
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.43859428
88	FoxO signaling pathway_Homo sapiens_hsa04068	0.41250639
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41115235
90	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.41058786
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40492106
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40426345
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40387021
94	Gastric acid secretion_Homo sapiens_hsa04971	0.40268128
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38917454
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37284671
97	Basal transcription factors_Homo sapiens_hsa03022	0.31834003
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31629232
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.31508313
100	Taste transduction_Homo sapiens_hsa04742	0.29915117

ARGFXP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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