ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	platelet dense granule organization (GO:0060155)	4.29910960
2	DNA deamination (GO:0045006)	4.13132507
3	preassembly of GPI anchor in ER membrane (GO:0016254)	3.91980244
4	response to pheromone (GO:0019236)	3.85780860
5	fucose catabolic process (GO:0019317)	3.77912313
6	L-fucose metabolic process (GO:0042354)	3.77912313
7	L-fucose catabolic process (GO:0042355)	3.77912313
8	mannosylation (GO:0097502)	3.63842214
9	indolalkylamine metabolic process (GO:0006586)	3.63377373
10	tryptophan metabolic process (GO:0006568)	3.61074294
11	behavioral response to nicotine (GO:0035095)	3.60285553
12	kynurenine metabolic process (GO:0070189)	3.52723357
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.49033676
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.49033676
15	indole-containing compound catabolic process (GO:0042436)	3.32983500
16	indolalkylamine catabolic process (GO:0046218)	3.32983500
17	tryptophan catabolic process (GO:0006569)	3.32983500
18	photoreceptor cell maintenance (GO:0045494)	3.21034164
19	protein K11-linked deubiquitination (GO:0035871)	3.16183415
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13966249
21	GPI anchor metabolic process (GO:0006505)	3.11060036
22	cell wall macromolecule metabolic process (GO:0044036)	3.07874604
23	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07399079
24	DNA double-strand break processing (GO:0000729)	3.07323997
25	replication fork processing (GO:0031297)	3.04663889
26	protein-cofactor linkage (GO:0018065)	3.02721428
27	cytochrome complex assembly (GO:0017004)	3.00103364
28	metallo-sulfur cluster assembly (GO:0031163)	2.97421966
29	iron-sulfur cluster assembly (GO:0016226)	2.97421966
30	axoneme assembly (GO:0035082)	2.96548057
31	piRNA metabolic process (GO:0034587)	2.96204052
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91793607
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88749423
34	GPI anchor biosynthetic process (GO:0006506)	2.85920435
35	S-adenosylmethionine metabolic process (GO:0046500)	2.84986246
36	ubiquinone biosynthetic process (GO:0006744)	2.83404824
37	peptidyl-histidine modification (GO:0018202)	2.80239884
38	recombinational repair (GO:0000725)	2.77809127
39	proteasome assembly (GO:0043248)	2.77401414
40	double-strand break repair via homologous recombination (GO:0000724)	2.76931630
41	water-soluble vitamin biosynthetic process (GO:0042364)	2.76848462
42	rRNA catabolic process (GO:0016075)	2.76397805
43	aggressive behavior (GO:0002118)	2.76323774
44	pyrimidine dimer repair (GO:0006290)	2.75990754
45	protein polyglutamylation (GO:0018095)	2.75519922
46	reciprocal meiotic recombination (GO:0007131)	2.74474565
47	reciprocal DNA recombination (GO:0035825)	2.74474565
48	detection of light stimulus involved in visual perception (GO:0050908)	2.74253030
49	detection of light stimulus involved in sensory perception (GO:0050962)	2.74253030
50	neural tube formation (GO:0001841)	2.74230699
51	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72535460
52	respiratory chain complex IV assembly (GO:0008535)	2.72158377
53	C-terminal protein lipidation (GO:0006501)	2.71997731
54	L-methionine salvage (GO:0071267)	2.69595719
55	L-methionine biosynthetic process (GO:0071265)	2.69595719
56	amino acid salvage (GO:0043102)	2.69595719
57	retinal cone cell development (GO:0046549)	2.69477493
58	negative regulation of telomere maintenance (GO:0032205)	2.69007707
59	dopamine transport (GO:0015872)	2.68130288
60	inositol phosphate catabolic process (GO:0071545)	2.67450228
61	regulation of glucokinase activity (GO:0033131)	2.65414420
62	regulation of hexokinase activity (GO:1903299)	2.65414420
63	adenosine metabolic process (GO:0046085)	2.64064288
64	cytidine metabolic process (GO:0046087)	2.64035580
65	cytidine catabolic process (GO:0006216)	2.64035580
66	cytidine deamination (GO:0009972)	2.64035580
67	behavioral response to ethanol (GO:0048149)	2.62960746
68	cellular ketone body metabolic process (GO:0046950)	2.62790789
69	glycolipid biosynthetic process (GO:0009247)	2.60679975
70	C-terminal protein amino acid modification (GO:0018410)	2.60631659
71	male meiosis I (GO:0007141)	2.58097814
72	ubiquinone metabolic process (GO:0006743)	2.57934311
73	cell wall macromolecule catabolic process (GO:0016998)	2.57563393
74	benzene-containing compound metabolic process (GO:0042537)	2.56638074
75	pseudouridine synthesis (GO:0001522)	2.56268560
76	indole-containing compound metabolic process (GO:0042430)	2.55270663
77	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.55040970
78	cellular biogenic amine catabolic process (GO:0042402)	2.54458674
79	amine catabolic process (GO:0009310)	2.54458674
80	regulation of mitotic spindle checkpoint (GO:1903504)	2.52327086
81	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.52327086
82	establishment of protein localization to Golgi (GO:0072600)	2.50961337
83	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.50551192
84	inositol phosphate dephosphorylation (GO:0046855)	2.50551192
85	cilium morphogenesis (GO:0060271)	2.50422597
86	DNA methylation involved in gamete generation (GO:0043046)	2.48341170
87	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.46386732
88	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.46386732
89	isotype switching (GO:0045190)	2.46386732
90	regulation of transmission of nerve impulse (GO:0051969)	2.46256879
91	DNA demethylation (GO:0080111)	2.46233112
92	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.45528026
93	synapsis (GO:0007129)	2.45280981
94	photoreceptor cell development (GO:0042461)	2.44250070
95	negative regulation of mast cell activation (GO:0033004)	2.42769763
96	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.42259921
97	multicellular organism reproduction (GO:0032504)	2.40964312
98	positive regulation of fatty acid transport (GO:2000193)	2.39847736
99	nucleotide transmembrane transport (GO:1901679)	2.38521502
100	cornea development in camera-type eye (GO:0061303)	2.37520470

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92432420
2	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87066822
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.67937537
4	VDR_22108803_ChIP-Seq_LS180_Human	2.67118712
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.48168827
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.47470165
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44974907
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26219651
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.20488230
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.19629263
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18300485
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.17541016
13	EWS_26573619_Chip-Seq_HEK293_Human	2.09378048
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03966690
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03614949
16	P300_19829295_ChIP-Seq_ESCs_Human	2.01933624
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.97040649
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96826881
19	FUS_26573619_Chip-Seq_HEK293_Human	1.95724331
20	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90705073
21	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85302868
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82766482
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.77735476
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73558254
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71279620
26	* ER_23166858_ChIP-Seq_MCF-7_Human	1.71251407
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70815691
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.70815691
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69350574
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68938791
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68524941
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68326369
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.66861940
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.59674624
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.58551198
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56610184
37	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55342836
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.48927375
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42700236
40	GATA3_26560356_Chip-Seq_TH2_Human	1.42088235
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39321222
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.39028736
43	AR_20517297_ChIP-Seq_VCAP_Human	1.37758518
44	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.37171226
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35665846
46	STAT3_23295773_ChIP-Seq_U87_Human	1.35659311
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35373146
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35373146
49	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.35255884
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35190565
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35082843
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33223785
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32371906
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32267694
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31295173
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31295173
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31201794
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31123671
59	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.30971847
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30661358
61	AR_25329375_ChIP-Seq_VCAP_Human	1.30021172
62	TCF4_23295773_ChIP-Seq_U87_Human	1.29133904
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27459419
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25448625
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24785580
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24761946
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23492794
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.23185490
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22612266
70	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21004547
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18826483
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18607560
73	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18516829
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17111239
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17014732
76	FOXP3_21729870_ChIP-Seq_TREG_Human	1.15768477
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15311266
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15178954
79	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13565982
80	NCOR_22424771_ChIP-Seq_293T_Human	1.12949094
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10623242
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.10245568
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09959867
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09772233
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08672278
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05295089
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05140216
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03956985
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02068266
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01617904
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00897324
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00523828
93	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99763318
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99460099
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.99348547
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99044071
97	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98922858
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98922858
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98246377
100	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.98151563

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.20574020
2	MP0003195_calcinosis	3.28916266
3	MP0001986_abnormal_taste_sensitivity	2.90336682
4	MP0002102_abnormal_ear_morphology	2.82099907
5	MP0005645_abnormal_hypothalamus_physiol	2.73147633
6	MP0003787_abnormal_imprinting	2.71963199
7	MP0006072_abnormal_retinal_apoptosis	2.56274949
8	MP0002638_abnormal_pupillary_reflex	2.49468331
9	MP0000569_abnormal_digit_pigmentation	2.46638847
10	MP0005551_abnormal_eye_electrophysiolog	2.36498572
11	MP0005646_abnormal_pituitary_gland	2.12971765
12	MP0000372_irregular_coat_pigmentation	2.08857043
13	MP0005253_abnormal_eye_physiology	1.96878666
14	MP0001968_abnormal_touch/_nociception	1.87286150
15	MP0008058_abnormal_DNA_repair	1.79724351
16	MP0002138_abnormal_hepatobiliary_system	1.79333083
17	MP0008872_abnormal_physiological_respon	1.78124463
18	MP0004147_increased_porphyrin_level	1.73222518
19	MP0005075_abnormal_melanosome_morpholog	1.69341584
20	MP0005084_abnormal_gallbladder_morpholo	1.69093581
21	MP0003880_abnormal_central_pattern	1.68069083
22	MP0003011_delayed_dark_adaptation	1.66524938
23	MP0001764_abnormal_homeostasis	1.65381151
24	MP0005671_abnormal_response_to	1.59952344
25	MP0009046_muscle_twitch	1.59066045
26	MP0005174_abnormal_tail_pigmentation	1.53300473
27	MP0001984_abnormal_olfaction	1.49643369
28	MP0002928_abnormal_bile_duct	1.49254578
29	MP0003724_increased_susceptibility_to	1.47824924
30	MP0002837_dystrophic_cardiac_calcinosis	1.46716261
31	MP0004043_abnormal_pH_regulation	1.46044096
32	MP0005389_reproductive_system_phenotype	1.40810585
33	MP0002876_abnormal_thyroid_physiology	1.36498816
34	MP0001919_abnormal_reproductive_system	1.29865723
35	MP0009745_abnormal_behavioral_response	1.27477082
36	MP0006292_abnormal_olfactory_placode	1.26127847
37	MP0002736_abnormal_nociception_after	1.23988509
38	MP0008875_abnormal_xenobiotic_pharmacok	1.23041269
39	MP0006276_abnormal_autonomic_nervous	1.21228670
40	MP0001501_abnormal_sleep_pattern	1.20066834
41	MP0000427_abnormal_hair_cycle	1.17422088
42	MP0008789_abnormal_olfactory_epithelium	1.14983133
43	MP0003252_abnormal_bile_duct	1.14177641
44	MP0003786_premature_aging	1.13589429
45	MP0000015_abnormal_ear_pigmentation	1.11138179
46	MP0001529_abnormal_vocalization	1.10974777
47	MP0001486_abnormal_startle_reflex	1.09350040
48	MP0001800_abnormal_humoral_immune	1.05763804
49	MP0004142_abnormal_muscle_tone	1.05723718
50	MP0005085_abnormal_gallbladder_physiolo	1.04853738
51	MP0002095_abnormal_skin_pigmentation	1.04025144
52	MP0002272_abnormal_nervous_system	1.01556306
53	MP0003718_maternal_effect	1.00253117
54	MP0005386_behavior/neurological_phenoty	0.99270559
55	MP0004924_abnormal_behavior	0.99270559
56	MP0002160_abnormal_reproductive_system	0.98255942
57	MP0004145_abnormal_muscle_electrophysio	0.97940161
58	MP0005332_abnormal_amino_acid	0.97829968
59	MP0008995_early_reproductive_senescence	0.96330512
60	MP0004133_heterotaxia	0.96234958
61	MP0001835_abnormal_antigen_presentation	0.95322328
62	MP0008775_abnormal_heart_ventricle	0.94898877
63	MP0005410_abnormal_fertilization	0.94767530
64	MP0002148_abnormal_hypersensitivity_rea	0.94729562
65	MP0010386_abnormal_urinary_bladder	0.93698860
66	MP0006036_abnormal_mitochondrial_physio	0.93121232
67	MP0001929_abnormal_gametogenesis	0.91555273
68	MP0005171_absent_coat_pigmentation	0.90375988
69	MP0005367_renal/urinary_system_phenotyp	0.89880570
70	MP0000516_abnormal_urinary_system	0.89880570
71	MP0002653_abnormal_ependyma_morphology	0.88319991
72	MP0002557_abnormal_social/conspecific_i	0.87728840
73	MP0003646_muscle_fatigue	0.86411015
74	MP0005167_abnormal_blood-brain_barrier	0.85897321
75	MP0006035_abnormal_mitochondrial_morpho	0.85398249
76	MP0002733_abnormal_thermal_nociception	0.85111720
77	MP0009697_abnormal_copulation	0.84968628
78	MP0003121_genomic_imprinting	0.84857236
79	MP0001502_abnormal_circadian_rhythm	0.84519752
80	MP0002229_neurodegeneration	0.84361056
81	MP0000383_abnormal_hair_follicle	0.84091558
82	MP0002572_abnormal_emotion/affect_behav	0.82999992
83	MP0009764_decreased_sensitivity_to	0.82479353
84	MP0000631_abnormal_neuroendocrine_gland	0.81463656
85	MP0002735_abnormal_chemical_nociception	0.80947773
86	MP0001905_abnormal_dopamine_level	0.79945866
87	MP0002234_abnormal_pharynx_morphology	0.79923316
88	MP0005083_abnormal_biliary_tract	0.79681146
89	MP0000465_gastrointestinal_hemorrhage	0.78933835
90	MP0004215_abnormal_myocardial_fiber	0.78872740
91	MP0002723_abnormal_immune_serum	0.77966707
92	MP0008057_abnormal_DNA_replication	0.76511786
93	MP0000653_abnormal_sex_gland	0.76180103
94	MP0005220_abnormal_exocrine_pancreas	0.74041028
95	MP0000230_abnormal_systemic_arterial	0.73887592
96	MP0002938_white_spotting	0.73798986
97	MP0002693_abnormal_pancreas_physiology	0.73713212
98	MP0001970_abnormal_pain_threshold	0.73305453
99	MP0000689_abnormal_spleen_morphology	0.72380243
100	MP0003698_abnormal_male_reproductive	0.72300946

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.50169991
2	Pancreatic fibrosis (HP:0100732)	3.94315245
3	Nephronophthisis (HP:0000090)	3.69842489
4	Abnormality of the renal cortex (HP:0011035)	3.64605666
5	True hermaphroditism (HP:0010459)	3.58162071
6	Congenital stationary night blindness (HP:0007642)	3.54289916
7	Abnormality of midbrain morphology (HP:0002418)	3.53769324
8	Molar tooth sign on MRI (HP:0002419)	3.53769324
9	Stomach cancer (HP:0012126)	3.37163559
10	Abnormality of the renal medulla (HP:0100957)	3.30451061
11	Renal cortical cysts (HP:0000803)	3.17235874
12	Abolished electroretinogram (ERG) (HP:0000550)	3.15263616
13	Chronic hepatic failure (HP:0100626)	2.84023729
14	Bile duct proliferation (HP:0001408)	2.82294956
15	Abnormal biliary tract physiology (HP:0012439)	2.82294956
16	Type II lissencephaly (HP:0007260)	2.81480187
17	Thyroiditis (HP:0100646)	2.75718604
18	Medial flaring of the eyebrow (HP:0010747)	2.75677043
19	Attenuation of retinal blood vessels (HP:0007843)	2.72656343
20	Hypothermia (HP:0002045)	2.68145676
21	Abnormality of B cell number (HP:0010975)	2.67165168
22	Abnormal drinking behavior (HP:0030082)	2.60793307
23	Polydipsia (HP:0001959)	2.60793307
24	Stomatitis (HP:0010280)	2.59381473
25	Tubular atrophy (HP:0000092)	2.53385328
26	Cystic liver disease (HP:0006706)	2.53103627
27	Hyperventilation (HP:0002883)	2.38626882
28	IgG deficiency (HP:0004315)	2.33975266
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29358561
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28457970
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.27979257
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.27979257
33	Abnormal protein glycosylation (HP:0012346)	2.27979257
34	Abnormal glycosylation (HP:0012345)	2.27979257
35	Gaze-evoked nystagmus (HP:0000640)	2.26732368
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.24011503
37	Agammaglobulinemia (HP:0004432)	2.23953853
38	Progressive inability to walk (HP:0002505)	2.20909850
39	B lymphocytopenia (HP:0010976)	2.19537268
40	Asplenia (HP:0001746)	2.18532125
41	Sclerocornea (HP:0000647)	2.17626167
42	Ketoacidosis (HP:0001993)	2.12245920
43	Severe combined immunodeficiency (HP:0004430)	2.12086196
44	Panhypogammaglobulinemia (HP:0003139)	2.10186130
45	Congenital hepatic fibrosis (HP:0002612)	2.09537211
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.08655106
47	Type I transferrin isoform profile (HP:0003642)	2.06457540
48	Polyuria (HP:0000103)	2.04903791
49	3-Methylglutaconic aciduria (HP:0003535)	2.03594588
50	Inability to walk (HP:0002540)	2.00568471
51	Progressive microcephaly (HP:0000253)	2.00390668
52	Congenital primary aphakia (HP:0007707)	1.99591100
53	Abnormality of macular pigmentation (HP:0008002)	1.99138689
54	Cutaneous melanoma (HP:0012056)	1.96578531
55	Methylmalonic aciduria (HP:0012120)	1.96134713
56	Gait imbalance (HP:0002141)	1.94761891
57	Ketosis (HP:0001946)	1.94064683
58	Increased CSF lactate (HP:0002490)	1.94010405
59	Decreased central vision (HP:0007663)	1.91697904
60	Disproportionate short-trunk short stature (HP:0003521)	1.89970979
61	Mitochondrial inheritance (HP:0001427)	1.89937809
62	Febrile seizures (HP:0002373)	1.88497427
63	Abnormality of eosinophils (HP:0001879)	1.85576196
64	Nephrogenic diabetes insipidus (HP:0009806)	1.85411780
65	Clumsiness (HP:0002312)	1.85123629
66	Progressive macrocephaly (HP:0004481)	1.84803911
67	Retinal dysplasia (HP:0007973)	1.83617941
68	Hepatocellular necrosis (HP:0001404)	1.83272159
69	Hepatic necrosis (HP:0002605)	1.82973761
70	Acute necrotizing encephalopathy (HP:0006965)	1.80690310
71	Lissencephaly (HP:0001339)	1.79241628
72	Methylmalonic acidemia (HP:0002912)	1.77822886
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77552310
74	Pendular nystagmus (HP:0012043)	1.77416493
75	Postaxial foot polydactyly (HP:0001830)	1.76902643
76	Intestinal atresia (HP:0011100)	1.75856117
77	Prostate neoplasm (HP:0100787)	1.75399114
78	Eosinophilia (HP:0001880)	1.73679388
79	Furrowed tongue (HP:0000221)	1.73552331
80	Constricted visual fields (HP:0001133)	1.73479841
81	Increased corneal curvature (HP:0100692)	1.73014560
82	Keratoconus (HP:0000563)	1.73014560
83	Hyperglycinuria (HP:0003108)	1.72487136
84	Fair hair (HP:0002286)	1.72204875
85	Focal motor seizures (HP:0011153)	1.72195888
86	Tachypnea (HP:0002789)	1.71413916
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.71036339
88	Large for gestational age (HP:0001520)	1.70236840
89	Hemiparesis (HP:0001269)	1.69666119
90	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69018299
91	Increased serum lactate (HP:0002151)	1.67783901
92	Abnormal urine output (HP:0012590)	1.67051434
93	Broad-based gait (HP:0002136)	1.66999129
94	Anencephaly (HP:0002323)	1.65578551
95	Acute encephalopathy (HP:0006846)	1.64595014
96	Abnormality of the prostate (HP:0008775)	1.64574193
97	Dyskinesia (HP:0100660)	1.63960752
98	Thyroid-stimulating hormone excess (HP:0002925)	1.63513395
99	Chorioretinal atrophy (HP:0000533)	1.63273779
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.63073030

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.52306409
2	TAOK3	2.76201374
3	NUAK1	2.69796028
4	ADRBK2	2.67216886
5	ZAK	2.63759196
6	MAP4K2	2.62700189
7	BMPR1B	2.61424097
8	GRK1	2.22809414
9	WNK3	2.12335582
10	PINK1	2.07861102
11	BCKDK	1.94817457
12	MST4	1.93539308
13	MAPK13	1.92399885
14	TXK	1.86685926
15	EIF2AK3	1.63727888
16	ACVR1B	1.49157354
17	MUSK	1.48749786
18	PLK2	1.47658354
19	TEC	1.47556325
20	TRIM28	1.46606363
21	ERBB3	1.45759625
22	INSRR	1.29636188
23	MAP3K4	1.25638128
24	ITK	1.25578351
25	CDK8	1.24266960
26	PAK3	1.22048719
27	PLK4	1.19182635
28	IKBKB	1.18924063
29	KIT	1.18711301
30	MAPKAPK3	1.15824432
31	DAPK2	1.07081774
32	OXSR1	1.06907521
33	GRK6	1.03733101
34	PHKG2	1.03717677
35	PHKG1	1.03717677
36	BCR	1.03681393
37	BMPR2	0.98468348
38	PRKCE	0.97129820
39	BRSK2	0.96803732
40	TNIK	0.94405622
41	SYK	0.92960948
42	NTRK3	0.88236409
43	SRPK1	0.86127866
44	FER	0.86123930
45	FGFR2	0.85848085
46	STK38L	0.84660395
47	PTK2B	0.84508092
48	WNK4	0.82289520
49	STK39	0.81045998
50	FLT3	0.79158076
51	CASK	0.77770004
52	IKBKE	0.76679199
53	MAP2K7	0.76280665
54	ADRBK1	0.75492797
55	TGFBR1	0.74607053
56	TNK2	0.73309685
57	MAP4K1	0.72934110
58	PIK3CA	0.72538072
59	CSNK1G3	0.71876963
60	MKNK2	0.70165485
61	TLK1	0.67446730
62	PRKCQ	0.67011523
63	EPHA4	0.62193571
64	PKN1	0.62164127
65	CSNK1G1	0.61707252
66	VRK1	0.61268387
67	LYN	0.61263401
68	IRAK1	0.61124234
69	PLK3	0.60031701
70	KDR	0.59142146
71	CSNK1G2	0.58090433
72	PIK3CG	0.55778937
73	RPS6KA5	0.51992043
74	CHUK	0.48420615
75	ATR	0.48347494
76	IGF1R	0.47618533
77	MAP3K14	0.47095910
78	FES	0.46707485
79	CSNK1A1L	0.46665097
80	PIM2	0.46508553
81	TRPM7	0.44730439
82	CAMKK2	0.43869506
83	PRKCI	0.43673119
84	MAP2K1	0.42925621
85	ABL1	0.42264590
86	PLK1	0.42042301
87	CSNK1A1	0.41477219
88	LCK	0.41423058
89	BTK	0.40429665
90	ATM	0.39947014
91	PRKCG	0.39485003
92	PRKACA	0.38017057
93	CAMK1	0.37073958
94	MARK1	0.36785720
95	MARK3	0.35116029
96	GRK7	0.34945371
97	PRKCA	0.34858434
98	CAMK2A	0.34658946
99	EIF2AK2	0.33070062
100	PRKAA1	0.32521973

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.13530139
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42855678
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.38829304
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.37142362
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.36670493
6	Protein export_Homo sapiens_hsa03060	2.34395809
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28409023
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.24889302
9	Phototransduction_Homo sapiens_hsa04744	2.23033363
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.20282091
11	Butanoate metabolism_Homo sapiens_hsa00650	2.06442576
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03597093
13	Homologous recombination_Homo sapiens_hsa03440	2.03493518
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.03302231
15	Asthma_Homo sapiens_hsa05310	1.99762058
16	Basal transcription factors_Homo sapiens_hsa03022	1.89549099
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88188158
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.87373438
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82416757
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.71222128
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70715711
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.66650179
23	Allograft rejection_Homo sapiens_hsa05330	1.61096560
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.59571769
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57852883
26	Propanoate metabolism_Homo sapiens_hsa00640	1.57164118
27	Proteasome_Homo sapiens_hsa03050	1.53366539
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48388254
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.47539130
30	RNA polymerase_Homo sapiens_hsa03020	1.47527996
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46914001
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44364985
33	RNA degradation_Homo sapiens_hsa03018	1.41403555
34	Peroxisome_Homo sapiens_hsa04146	1.39787455
35	Oxidative phosphorylation_Homo sapiens_hsa00190	1.34229805
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.33412319
37	Caffeine metabolism_Homo sapiens_hsa00232	1.32625942
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.27022197
39	Regulation of autophagy_Homo sapiens_hsa04140	1.25288965
40	Olfactory transduction_Homo sapiens_hsa04740	1.24894620
41	Taste transduction_Homo sapiens_hsa04742	1.08790826
42	Parkinsons disease_Homo sapiens_hsa05012	1.03738192
43	Fatty acid elongation_Homo sapiens_hsa00062	1.02117423
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01815883
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00284337
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98829480
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98096071
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94807120
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.93192091
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92110816
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.91404356
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91222624
53	Mismatch repair_Homo sapiens_hsa03430	0.91133411
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90847148
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89671124
56	Retinol metabolism_Homo sapiens_hsa00830	0.88226435
57	ABC transporters_Homo sapiens_hsa02010	0.87468694
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87377036
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86649788
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83233191
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.75849571
62	Fatty acid degradation_Homo sapiens_hsa00071	0.75524980
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73456174
64	Nicotine addiction_Homo sapiens_hsa05033	0.72938495
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71126976
66	One carbon pool by folate_Homo sapiens_hsa00670	0.69378629
67	Sulfur metabolism_Homo sapiens_hsa00920	0.67843353
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66141127
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.63750530
70	Morphine addiction_Homo sapiens_hsa05032	0.59450173
71	Base excision repair_Homo sapiens_hsa03410	0.58078843
72	Purine metabolism_Homo sapiens_hsa00230	0.56705487
73	Metabolic pathways_Homo sapiens_hsa01100	0.55577635
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55279371
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.55031886
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54561965
77	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.53688141
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51961400
79	Huntingtons disease_Homo sapiens_hsa05016	0.51415684
80	Serotonergic synapse_Homo sapiens_hsa04726	0.50929496
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50242919
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49495587
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49226430
84	Lysine degradation_Homo sapiens_hsa00310	0.46844695
85	RNA transport_Homo sapiens_hsa03013	0.46190863
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44495087
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43329321
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42706907
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42421900
90	Alzheimers disease_Homo sapiens_hsa05010	0.41659394
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41372159
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40891520
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39961903
94	Salivary secretion_Homo sapiens_hsa04970	0.39024815
95	GABAergic synapse_Homo sapiens_hsa04727	0.38291522
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37381299
97	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35517978
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35368087
99	Glutathione metabolism_Homo sapiens_hsa00480	0.35244741
100	Circadian rhythm_Homo sapiens_hsa04710	0.33880526

ARGFXP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »