ARHGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04585301
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04585301
3regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.93724844
4regulation of extracellular matrix disassembly (GO:0010715)4.80818623
5positive regulation of tolerance induction (GO:0002645)4.80346920
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.65972323
7antigen processing and presentation of endogenous antigen (GO:0019883)4.65163765
8glomerular epithelial cell development (GO:0072310)4.52442952
9axon extension involved in axon guidance (GO:0048846)4.36988360
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.36988360
11glomerular basement membrane development (GO:0032836)4.33952680
12negative regulation of T cell differentiation in thymus (GO:0033085)4.31219439
13regulation of tolerance induction (GO:0002643)4.24247249
14COPI coating of Golgi vesicle (GO:0048205)4.02127301
15Golgi transport vesicle coating (GO:0048200)4.02127301
16negative regulation of execution phase of apoptosis (GO:1900118)4.00416442
17regulation of type B pancreatic cell apoptotic process (GO:2000674)3.96804542
18keratan sulfate catabolic process (GO:0042340)3.91188526
19tolerance induction (GO:0002507)3.66193600
20negative regulation of protein autophosphorylation (GO:0031953)3.61842213
21establishment of apical/basal cell polarity (GO:0035089)3.51235736
22regulation of execution phase of apoptosis (GO:1900117)3.43968329
23regulation of translation in response to stress (GO:0043555)3.19043433
24renal filtration (GO:0097205)3.16240733
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14528524
26peptide hormone processing (GO:0016486)3.12959962
27glomerular filtration (GO:0003094)3.12834606
28establishment of monopolar cell polarity (GO:0061162)3.11982513
29establishment or maintenance of monopolar cell polarity (GO:0061339)3.11982513
30cell proliferation involved in metanephros development (GO:0072203)3.08421844
31extracellular fibril organization (GO:0043206)3.07075987
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06802240
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03912240
34fibril organization (GO:0097435)3.02007651
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94049336
36positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.93508522
37lung epithelium development (GO:0060428)2.92863434
38regulation of autophagic vacuole assembly (GO:2000785)2.90756429
39regulation of transforming growth factor beta2 production (GO:0032909)2.89310079
40peptidyl-histidine modification (GO:0018202)2.87698670
41regulation of vacuole organization (GO:0044088)2.87035916
42negative regulation of complement activation (GO:0045916)2.86191565
43epithelial cell fate commitment (GO:0072148)2.82449544
44protein retention in ER lumen (GO:0006621)2.82105183
45protein heterotrimerization (GO:0070208)2.81373135
46histamine secretion (GO:0001821)2.80708115
47glycerophospholipid catabolic process (GO:0046475)2.76946015
48formation of translation preinitiation complex (GO:0001731)2.73362235
49positive regulation of epithelial to mesenchymal transition (GO:0010718)2.71728226
50desmosome organization (GO:0002934)2.67249521
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.66554321
52positive regulation of lamellipodium assembly (GO:0010592)2.64609613
53negative regulation of B cell mediated immunity (GO:0002713)2.63142803
54negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63142803
55sequestering of extracellular ligand from receptor (GO:0035581)2.61913548
56glomerular visceral epithelial cell development (GO:0072015)2.60882790
57regulation of integrin-mediated signaling pathway (GO:2001044)2.58982124
58mesenchyme morphogenesis (GO:0072132)2.57713030
59sphingosine metabolic process (GO:0006670)2.56885056
60heparin biosynthetic process (GO:0030210)2.56636056
61heparin metabolic process (GO:0030202)2.56636056
62protein maturation by protein folding (GO:0022417)2.56079874
63inositol phosphate catabolic process (GO:0071545)2.54836790
64insulin secretion (GO:0030073)2.52943879
65xenobiotic catabolic process (GO:0042178)2.52911244
66negative regulation of cAMP-mediated signaling (GO:0043951)2.52542615
67positive regulation of BMP signaling pathway (GO:0030513)2.52098027
68trabecula morphogenesis (GO:0061383)2.52074834
69positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.51933940
70response to gravity (GO:0009629)2.50078690
71type B pancreatic cell proliferation (GO:0044342)2.49313296
72Notch signaling involved in heart development (GO:0061314)2.48888507
73positive regulation of calcium ion import (GO:0090280)2.48439379
74membrane budding (GO:0006900)2.47174452
75negative regulation of protein activation cascade (GO:2000258)2.45393292
76chondrocyte proliferation (GO:0035988)2.44752421
77atrioventricular valve morphogenesis (GO:0003181)2.42777013
78cellular response to zinc ion (GO:0071294)2.42533580
79macroautophagy (GO:0016236)2.41496020
80fibroblast migration (GO:0010761)2.39976216
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39938227
82mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39938227
83positive regulation of keratinocyte differentiation (GO:0045618)2.39844235
84negative regulation of smooth muscle cell migration (GO:0014912)2.39808798
85negative regulation of humoral immune response (GO:0002921)2.39650077
86regulation of SMAD protein import into nucleus (GO:0060390)2.38867645
87cell proliferation involved in kidney development (GO:0072111)2.38600859
88negative thymic T cell selection (GO:0045060)2.37620431
89endothelial tube morphogenesis (GO:0061154)2.37284702
90morphogenesis of an endothelium (GO:0003159)2.37284702
91positive regulation of fibroblast migration (GO:0010763)2.36953858
92negative T cell selection (GO:0043383)2.36706932
93regulation of metalloenzyme activity (GO:0048552)2.36499264
94negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.35998289
95cellular response to vitamin (GO:0071295)2.33667621
96chondrocyte development (GO:0002063)2.33367143
97wound healing, spreading of epidermal cells (GO:0035313)2.32307295
98positive regulation of macroautophagy (GO:0016239)2.32269776
99positive regulation of actin filament depolymerization (GO:0030836)2.32221494
100negative regulation of phagocytosis (GO:0050765)2.31723677
101cellular response to vitamin D (GO:0071305)2.30662727
102histamine transport (GO:0051608)2.29634645
103chaperone mediated protein folding requiring cofactor (GO:0051085)2.29468823
104positive regulation of gluconeogenesis (GO:0045722)2.28479165
105cellular ketone body metabolic process (GO:0046950)2.28317506
106diol metabolic process (GO:0034311)2.27724678
107zinc ion homeostasis (GO:0055069)2.27529231
108ventricular trabecula myocardium morphogenesis (GO:0003222)2.27363636
109epithelial cell-cell adhesion (GO:0090136)2.27089643
110COPII vesicle coating (GO:0048208)2.26834432
111regulation of chemokine-mediated signaling pathway (GO:0070099)2.26774019
112positive regulation of insulin secretion (GO:0032024)2.26564993
113positive regulation of lamellipodium organization (GO:1902745)2.26466453
114leukocyte aggregation (GO:0070486)2.26058020
115barbed-end actin filament capping (GO:0051016)2.26018724
116regulation of T cell differentiation in thymus (GO:0033081)2.24297288
117endocrine pancreas development (GO:0031018)2.24217679
118NIK/NF-kappaB signaling (GO:0038061)2.23759782
119actin nucleation (GO:0045010)2.23408824
120negative regulation of leukocyte chemotaxis (GO:0002689)2.23232303
121lactate metabolic process (GO:0006089)2.23171869
122platelet aggregation (GO:0070527)2.23050588
123regulation of transforming growth factor beta1 production (GO:0032908)2.22693445
124IMP biosynthetic process (GO:0006188)2.22191423
125regulation of T cell tolerance induction (GO:0002664)2.21551598
126positive regulation of SMAD protein import into nucleus (GO:0060391)2.21155602
127phosphorylated carbohydrate dephosphorylation (GO:0046838)2.20874677
128inositol phosphate dephosphorylation (GO:0046855)2.20874677
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.20794331
130L-phenylalanine metabolic process (GO:0006558)2.20794331
131cytochrome complex assembly (GO:0017004)2.20546431
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.19791329
133response to pH (GO:0009268)2.19064404
134sphingoid metabolic process (GO:0046519)2.18594365
135antigen processing and presentation via MHC class Ib (GO:0002475)2.18200946
136peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.18098481
137embryonic foregut morphogenesis (GO:0048617)2.17441587
138adaptation of signaling pathway (GO:0023058)2.17305242
139white fat cell differentiation (GO:0050872)2.17270772
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.16947445
141positive regulation of transforming growth factor beta production (GO:0071636)2.16555306
142chondroitin sulfate catabolic process (GO:0030207)2.16298532
143DNA synthesis involved in DNA repair (GO:0000731)2.15759936
144myelin maintenance (GO:0043217)2.15175866
145nodal signaling pathway (GO:0038092)2.14979796
146endosome to pigment granule transport (GO:0043485)2.14903131
147endosome to melanosome transport (GO:0035646)2.14903131
148negative regulation of glycoprotein biosynthetic process (GO:0010561)2.14337287
149nitric oxide mediated signal transduction (GO:0007263)2.14245876
150platelet dense granule organization (GO:0060155)2.14091779
151L-phenylalanine catabolic process (GO:0006559)2.14075031
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.14075031
153alanine transport (GO:0032328)2.13789718
154respiratory chain complex IV assembly (GO:0008535)2.13548786
155negative chemotaxis (GO:0050919)2.13112172
156retinol metabolic process (GO:0042572)2.13013958
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.11686541
158positive regulation of histone deacetylation (GO:0031065)2.11426656
159negative regulation of cell size (GO:0045792)2.11063145
160interferon-gamma secretion (GO:0072643)2.09453979
161skin morphogenesis (GO:0043589)2.08682678
162antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.07780629
163nucleobase biosynthetic process (GO:0046112)2.07365278
164actin filament depolymerization (GO:0030042)2.07344309
165extracellular regulation of signal transduction (GO:1900115)2.06904857
166extracellular negative regulation of signal transduction (GO:1900116)2.06904857
167negative regulation of translational initiation (GO:0045947)2.05684940
168keratan sulfate metabolic process (GO:0042339)2.05505636
169sphingomyelin metabolic process (GO:0006684)2.04646727
170regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.04386397
171ketone body metabolic process (GO:1902224)2.04040968
172negative regulation of viral entry into host cell (GO:0046597)2.03568415
173smooth muscle tissue development (GO:0048745)2.03529192
174venous blood vessel morphogenesis (GO:0048845)2.03421571
175positive regulation of gamma-delta T cell activation (GO:0046645)2.02772613
176response to hepatocyte growth factor (GO:0035728)2.02429540
177cellular response to hepatocyte growth factor stimulus (GO:0035729)2.02429540
178regulation of mononuclear cell migration (GO:0071675)2.02300039
179regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.02123265
180wound healing, spreading of cells (GO:0044319)2.01708682
181collagen fibril organization (GO:0030199)2.00541075
182heart trabecula morphogenesis (GO:0061384)2.00538964
183cell migration involved in heart development (GO:0060973)2.00181211
184endocardial cushion morphogenesis (GO:0003203)1.99345156
185regulation of G0 to G1 transition (GO:0070316)1.99277658
186epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)1.98016027
187heterotypic cell-cell adhesion (GO:0034113)1.97657133
188regulation of cardioblast differentiation (GO:0051890)1.97260546
189cell adhesion mediated by integrin (GO:0033627)1.97146219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60595002
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.22975047
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76610371
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.63797123
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44749814
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76521037
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71776570
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.56385748
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.53096808
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.47046115
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42923345
12MYC_22102868_ChIP-Seq_BL_Human2.31009020
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18381283
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15325068
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12926597
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.11424809
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95116717
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.92867793
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85377324
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85314612
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83906690
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.83393171
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77042922
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74432361
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73666171
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73169504
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71830774
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70025837
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.67460989
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66354946
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62453959
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62417818
33VDR_21846776_ChIP-Seq_THP-1_Human1.59386240
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.58642998
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.58322599
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57643666
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56809726
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.54581686
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54199745
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53931067
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53408386
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51304574
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.47577581
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47184396
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45702155
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45450729
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45249764
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.43415583
49SOX2_20726797_ChIP-Seq_SW620_Human1.43326373
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43152256
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40897536
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39848825
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39617781
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37569357
55* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36729904
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34502505
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34415723
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34402352
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34109172
60* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33892463
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33821218
62XRN2_22483619_ChIP-Seq_HELA_Human1.33750391
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.33690983
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32505505
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32499724
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.32213519
67* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32092682
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32008342
69CIITA_25753668_ChIP-Seq_RAJI_Human1.31046589
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.30985282
71CJUN_26792858_Chip-Seq_BT549_Human1.30139140
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.30080308
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29491306
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29231188
75TFEB_21752829_ChIP-Seq_HELA_Human1.26535732
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.26087535
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25765114
78* GABP_19822575_ChIP-Seq_HepG2_Human1.25225115
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24450632
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23814771
81* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23438836
82MAF_26560356_Chip-Seq_TH1_Human1.23425216
83MYB_26560356_Chip-Seq_TH2_Human1.23011205
84CLOCK_20551151_ChIP-Seq_293T_Human1.22508130
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22254417
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22125384
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21538947
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20826768
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20231059
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19906970
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19012866
92AHR_22903824_ChIP-Seq_MCF-7_Human1.18888567
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.18879287
94ELK1_19687146_ChIP-ChIP_HELA_Human1.18777055
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18696315
96* SPI1_23547873_ChIP-Seq_NB4_Human1.17794206
97ATF3_27146783_Chip-Seq_COLON_Human1.17598080
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17088819
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.15857556
100AR_21909140_ChIP-Seq_LNCAP_Human1.15153921
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14500466
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14500466
103VDR_23849224_ChIP-Seq_CD4+_Human1.12161123
104GBX2_23144817_ChIP-Seq_PC3_Human1.12078710
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.11964234
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11745957
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.10788437
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10537599
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09368772
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08530513
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.08264639
112* E2F1_21310950_ChIP-Seq_MCF-7_Human1.08026486
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07682584
114VDR_24763502_ChIP-Seq_THP-1_Human1.07285523
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05188244
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05021726
117UTX_26944678_Chip-Seq_JUKART_Human1.04476308
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04252654
119TCF7_22412390_ChIP-Seq_EML_Mouse1.04100847
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02291195
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01920556
122BRD4_25478319_ChIP-Seq_HGPS_Human1.00029154
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99348218
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99248530
125SPI1_23127762_ChIP-Seq_K562_Human0.98535512
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98411038
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98334283
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97459259
129* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96560006
130* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96166049
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96159463
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96014617
133DCP1A_22483619_ChIP-Seq_HELA_Human0.95668292
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95617603
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94873059
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94230333
137ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93836347
138MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93523706
139HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93316589
140BCAT_22108803_ChIP-Seq_LS180_Human0.92754474
141* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91772258
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91741492
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91710502
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91133160
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90774826
146* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90532196
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90338859
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90332502
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89973202
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89074525
151RACK7_27058665_Chip-Seq_MCF-7_Human0.87810612
152MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87611113
153LXR_22292898_ChIP-Seq_THP-1_Human0.85174773
154* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85120025
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.84193195
156TBX20_22328084_ChIP-Seq_HEART_Mouse0.84193195
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.83696734
158EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82466472
159* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82239272
160GATA4_25053715_ChIP-Seq_YYC3_Human0.81165615
161* TP63_22573176_ChIP-Seq_HFKS_Human0.80955574
162FLI1_27457419_Chip-Seq_LIVER_Mouse0.80883591
163SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80648781
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79854640
165MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78252698
166NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78144605
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78144605
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76394432
169TP63_23658742_ChIP-Seq_EP156T_Human0.75692604
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75313125
171ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75218788
172IRF8_27001747_Chip-Seq_BMDM_Mouse0.75022175
173SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74408471
174GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74251295
175CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73563249
176SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73393944
177STAT1_20625510_ChIP-Seq_HELA_Human0.73037301
178SMC1_22415368_ChIP-Seq_MEFs_Mouse0.72757843
179GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72690041
180DROSHA_22980978_ChIP-Seq_HELA_Human0.72589588
181* TET1_21490601_ChIP-Seq_MESCs_Mouse0.72177992
182ELF1_20517297_ChIP-Seq_JURKAT_Human0.71438348
183FOXA1_25552417_ChIP-Seq_VCAP_Human0.70754734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.78577381
2MP0002254_reproductive_system_inflammat3.71697730
3MP0003195_calcinosis2.70959926
4MP0006054_spinal_hemorrhage2.65253414
5MP0000013_abnormal_adipose_tissue2.57671963
6MP0004084_abnormal_cardiac_muscle2.54386559
7MP0002837_dystrophic_cardiac_calcinosis2.50584545
8MP0008438_abnormal_cutaneous_collagen2.41465463
9MP0000537_abnormal_urethra_morphology2.34324324
10MP0010352_gastrointestinal_tract_polyps2.32066596
11MP0010386_abnormal_urinary_bladder2.28523255
12MP0010234_abnormal_vibrissa_follicle2.27731863
13MP0002876_abnormal_thyroid_physiology2.25889560
14MP0003566_abnormal_cell_adhesion2.23583771
15MP0003828_pulmonary_edema2.08397145
16MP0005076_abnormal_cell_differentiation2.03292103
17MP0005379_endocrine/exocrine_gland_phen1.98310333
18MP0003693_abnormal_embryo_hatching1.94060667
19MP0003122_maternal_imprinting1.92427808
20MP0004272_abnormal_basement_membrane1.88960775
21MP0002909_abnormal_adrenal_gland1.87019129
22MP0000685_abnormal_immune_system1.83598757
23MP0002693_abnormal_pancreas_physiology1.82998412
24MP0002295_abnormal_pulmonary_circulatio1.75862292
25MP0002877_abnormal_melanocyte_morpholog1.73611535
26MP0009384_cardiac_valve_regurgitation1.72225984
27MP0001756_abnormal_urination1.71899530
28MP0001944_abnormal_pancreas_morphology1.70678411
29MP0000003_abnormal_adipose_tissue1.70218651
30MP0003279_aneurysm1.67799278
31MP0003705_abnormal_hypodermis_morpholog1.64604700
32MP0005275_abnormal_skin_tensile1.59938900
33MP0003942_abnormal_urinary_system1.59418556
34MP0009840_abnormal_foam_cell1.57868876
35MP0008007_abnormal_cellular_replicative1.55224183
36MP0005503_abnormal_tendon_morphology1.54998693
37MP0001542_abnormal_bone_strength1.52888951
38MP0010030_abnormal_orbit_morphology1.52417187
39MP0003091_abnormal_cell_migration1.52071320
40MP0003763_abnormal_thymus_physiology1.50131378
41MP0001958_emphysema1.47185132
42MP0010329_abnormal_lipoprotein_level1.46748935
43MP0001835_abnormal_antigen_presentation1.44803542
44* MP0005023_abnormal_wound_healing1.44660709
45MP0000858_altered_metastatic_potential1.42300533
46MP0008057_abnormal_DNA_replication1.42141180
47MP0003283_abnormal_digestive_organ1.39899328
48MP0002060_abnormal_skin_morphology1.37897881
49MP0003045_fibrosis1.37749746
50MP0005220_abnormal_exocrine_pancreas1.36656158
51MP0005058_abnormal_lysosome_morphology1.33914288
52MP0005257_abnormal_intraocular_pressure1.33213705
53MP0003315_abnormal_perineum_morphology1.32402615
54MP0000490_abnormal_crypts_of1.32218434
55MP0003077_abnormal_cell_cycle1.31959843
56MP0002168_other_aberrant_phenotype1.31420140
57MP0000538_abnormal_urinary_bladder1.31072506
58MP0006082_CNS_inflammation1.28299143
59MP0000534_abnormal_ureter_morphology1.25639610
60MP0001879_abnormal_lymphatic_vessel1.25271662
61MP0005508_abnormal_skeleton_morphology1.24965519
62MP0004264_abnormal_extraembryonic_tissu1.24468309
63MP0009333_abnormal_splenocyte_physiolog1.23579720
64MP0004957_abnormal_blastocyst_morpholog1.20969556
65* MP0000350_abnormal_cell_proliferation1.20840580
66MP0003567_abnormal_fetal_cardiomyocyte1.20814772
67MP0005084_abnormal_gallbladder_morpholo1.19593876
68* MP0004808_abnormal_hematopoietic_stem1.19192510
69MP0003941_abnormal_skin_development1.18972259
70MP0002163_abnormal_gland_morphology1.17722119
71MP0003300_gastrointestinal_ulcer1.17518186
72MP0003075_altered_response_to1.16522732
73MP0000767_abnormal_smooth_muscle1.15645112
74MP0004019_abnormal_vitamin_homeostasis1.15272112
75MP0003724_increased_susceptibility_to1.14653923
76MP0000428_abnormal_craniofacial_morphol1.14279086
77MP0003191_abnormal_cellular_cholesterol1.13805150
78MP0009278_abnormal_bone_marrow1.11996658
79MP0005332_abnormal_amino_acid1.11239955
80MP0003950_abnormal_plasma_membrane1.09234018
81MP0003115_abnormal_respiratory_system1.08920449
82MP0001243_abnormal_dermal_layer1.07704748
83MP0003984_embryonic_growth_retardation1.07442828
84MP0002405_respiratory_system_inflammati1.06595178
85MP0003123_paternal_imprinting1.06130654
86MP0002078_abnormal_glucose_homeostasis1.05837483
87MP0001661_extended_life_span1.05692272
88MP0005397_hematopoietic_system_phenotyp1.04659072
89MP0001545_abnormal_hematopoietic_system1.04659072
90MP0005671_abnormal_response_to1.04643931
91MP0002088_abnormal_embryonic_growth/wei1.04050353
92MP0005621_abnormal_cell_physiology1.03495259
93MP0010368_abnormal_lymphatic_system1.03388530
94MP0003121_genomic_imprinting1.02918938
95MP0003172_abnormal_lysosome_physiology1.02373977
96MP0005390_skeleton_phenotype1.01983029
97MP0001348_abnormal_lacrimal_gland1.01404560
98MP0002933_joint_inflammation1.00392513
99MP0005646_abnormal_pituitary_gland1.00290047
100MP0001765_abnormal_ion_homeostasis0.99164623
101MP0000613_abnormal_salivary_gland0.98476279
102MP0002086_abnormal_extraembryonic_tissu0.98159558
103MP0002089_abnormal_postnatal_growth/wei0.98059885
104* MP0002396_abnormal_hematopoietic_system0.97406752
105MP0003448_altered_tumor_morphology0.97307795
106MP0003943_abnormal_hepatobiliary_system0.96851900
107* MP0003111_abnormal_nucleus_morphology0.96796732
108MP0000750_abnormal_muscle_regeneration0.96092117
109MP0004197_abnormal_fetal_growth/weight/0.95863435
110MP0001730_embryonic_growth_arrest0.95725950
111MP0000230_abnormal_systemic_arterial0.95607652
112MP0010307_abnormal_tumor_latency0.94494473
113MP0006138_congestive_heart_failure0.93985273
114MP0005385_cardiovascular_system_phenoty0.92739541
115MP0001544_abnormal_cardiovascular_syste0.92739541
116MP0008932_abnormal_embryonic_tissue0.92472449
117* MP0001697_abnormal_embryo_size0.92171412
118MP0000749_muscle_degeneration0.91929724
119MP0003436_decreased_susceptibility_to0.91681836
120MP0009643_abnormal_urine_homeostasis0.90125831
121MP0005595_abnormal_vascular_smooth0.89552463
122MP0001672_abnormal_embryogenesis/_devel0.89402033
123MP0005380_embryogenesis_phenotype0.89402033
124MP0004133_heterotaxia0.89159045
125MP0002925_abnormal_cardiovascular_devel0.89092475
126MP0005165_increased_susceptibility_to0.89049414
127MP0003183_abnormal_peptide_metabolism0.88644819
128MP0000015_abnormal_ear_pigmentation0.88187072
129MP0003011_delayed_dark_adaptation0.88116653
130MP0010630_abnormal_cardiac_muscle0.88055421
131* MP0000703_abnormal_thymus_morphology0.87340073
132MP0001533_abnormal_skeleton_physiology0.87295980
133MP0000427_abnormal_hair_cycle0.86099101
134MP0005448_abnormal_energy_balance0.85091892
135MP0004036_abnormal_muscle_relaxation0.84804562
136MP0005365_abnormal_bile_salt0.84567123
137MP0000343_altered_response_to0.84529415
138MP0010155_abnormal_intestine_physiology0.84373103
139* MP0005384_cellular_phenotype0.84283339
140MP0005083_abnormal_biliary_tract0.83739301
141MP0002166_altered_tumor_susceptibility0.83522235
142MP0008775_abnormal_heart_ventricle0.83486166
143MP0000516_abnormal_urinary_system0.83412037
144MP0005367_renal/urinary_system_phenotyp0.83412037
145MP0000733_abnormal_muscle_development0.82431798
146MP0005645_abnormal_hypothalamus_physiol0.82039779
147* MP0002398_abnormal_bone_marrow0.81813719
148MP0003252_abnormal_bile_duct0.81422822
149MP0004510_myositis0.81039446
150MP0002420_abnormal_adaptive_immunity0.80864942
151MP0005164_abnormal_response_to0.80861777
152MP0001819_abnormal_immune_cell0.80822556
153MP0000467_abnormal_esophagus_morphology0.80662733
154MP0001915_intracranial_hemorrhage0.80255890
155MP0001293_anophthalmia0.80014821
156MP0001664_abnormal_digestion0.80001415
157MP0002118_abnormal_lipid_homeostasis0.79898772
158MP0002452_abnormal_antigen_presenting0.79415950
159MP0002108_abnormal_muscle_morphology0.77350377
160MP0002896_abnormal_bone_mineralization0.76179345
161MP0004381_abnormal_hair_follicle0.73616137
162MP0005464_abnormal_platelet_physiology0.73202401
163MP0000639_abnormal_adrenal_gland0.72826080
164MP0005166_decreased_susceptibility_to0.72301661
165MP0009785_altered_susceptibility_to0.71436425
166MP0001501_abnormal_sleep_pattern0.71282981
167MP0003787_abnormal_imprinting0.71199455
168MP0000470_abnormal_stomach_morphology0.70283823
169MP0005636_abnormal_mineral_homeostasis0.69768607
170* MP0003795_abnormal_bone_structure0.69675990
171MP0004883_abnormal_blood_vessel0.69012435
172MP0005075_abnormal_melanosome_morpholog0.68695279
173MP0002136_abnormal_kidney_physiology0.67555276
174MP0002998_abnormal_bone_remodeling0.66859622
175MP0003953_abnormal_hormone_level0.66782975
176MP0004085_abnormal_heartbeat0.64125130

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of anterior horn cells (HP:0002398)4.60288284
2Abnormality of the anterior horn cell (HP:0006802)4.60288284
3Aortic aneurysm (HP:0004942)4.40473043
4Protrusio acetabuli (HP:0003179)3.96046650
5Abnormality of mucopolysaccharide metabolism (HP:0011020)3.86909799
6Abnormality of polysaccharide metabolism (HP:0011012)3.86909799
7Abnormality of glycosaminoglycan metabolism (HP:0004371)3.86909799
8Ankle contracture (HP:0006466)3.63728958
9Carpal bone hypoplasia (HP:0001498)3.46557224
10Spinal muscular atrophy (HP:0007269)3.46232941
11Aortic dissection (HP:0002647)3.32695288
12Increased CSF protein (HP:0002922)3.28905852
13Cardiovascular calcification (HP:0011915)3.26828081
14Mesangial abnormality (HP:0001966)3.23712586
15Abnormal pancreas size (HP:0012094)3.18579532
16Dysostosis multiplex (HP:0000943)3.18137331
17Vascular calcification (HP:0004934)3.14961251
18Cerebral aneurysm (HP:0004944)3.13943654
19Dilatation of the ascending aorta (HP:0005111)3.04401594
20Premature rupture of membranes (HP:0001788)2.94599994
21Hematochezia (HP:0002573)2.89175579
22Albinism (HP:0001022)2.84208152
23Hyperglycemia (HP:0003074)2.82347954
24Cervical subluxation (HP:0003308)2.80844445
25Diaphragmatic weakness (HP:0009113)2.80696358
26Abnormality of liposaccharide metabolism (HP:0010968)2.80475632
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.80475632
28Abnormality of glycolipid metabolism (HP:0010969)2.80475632
29Wrist flexion contracture (HP:0001239)2.78406930
30Hypoplasia of the fovea (HP:0007750)2.72795667
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.72795667
32Vertebral compression fractures (HP:0002953)2.67461394
33Atrophy/Degeneration involving motor neurons (HP:0007373)2.66981939
34Severe visual impairment (HP:0001141)2.62136839
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58181275
36Vascular tortuosity (HP:0004948)2.57732467
37Ketoacidosis (HP:0001993)2.57014108
38Lymphangioma (HP:0100764)2.57004272
39Asymmetry of the thorax (HP:0001555)2.54350125
40Mitral stenosis (HP:0001718)2.49118405
41Vacuolated lymphocytes (HP:0001922)2.48910682
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.47007356
43Arterial tortuosity (HP:0005116)2.46842223
44Progressive neurologic deterioration (HP:0002344)2.45585271
45Shallow orbits (HP:0000586)2.44701815
46Bicuspid aortic valve (HP:0001647)2.43679303
47Disproportionate short-trunk short stature (HP:0003521)2.43612597
48Hamartoma of the eye (HP:0010568)2.38577092
49Tongue fasciculations (HP:0001308)2.36807351
50Small epiphyses (HP:0010585)2.34333442
51Muscle fibrillation (HP:0010546)2.34287209
52Follicular hyperkeratosis (HP:0007502)2.31329409
53Hypokinesia (HP:0002375)2.29467319
54Abnormal rod and cone electroretinograms (HP:0008323)2.27659720
55Genu recurvatum (HP:0002816)2.27272511
56Abnormality of the fovea (HP:0000493)2.27244796
57Delayed closure of the anterior fontanelle (HP:0001476)2.26046576
58Episodic fever (HP:0001954)2.23002523
59Abnormal foot bone ossification (HP:0010675)2.22766489
60Insulin-resistant diabetes mellitus (HP:0000831)2.22673426
61Bone cyst (HP:0012062)2.21970410
62Long palpebral fissure (HP:0000637)2.21878420
63Hemiparesis (HP:0001269)2.20844867
64Congenital stationary night blindness (HP:0007642)2.20102419
65Prolonged neonatal jaundice (HP:0006579)2.16613667
66Flattened epiphyses (HP:0003071)2.16096051
67Stomatitis (HP:0010280)2.15099858
68Slender build (HP:0001533)2.13385372
69Hypothermia (HP:0002045)2.12384604
70Nuclear cataract (HP:0100018)2.11425811
71Congenital malformation of the right heart (HP:0011723)2.10304372
72Double outlet right ventricle (HP:0001719)2.10304372
73Delayed gross motor development (HP:0002194)2.09192867
74Hypoglycemic coma (HP:0001325)2.08568839
75Stridor (HP:0010307)2.04998386
76Metaphyseal dysplasia (HP:0100255)2.04915749
77Peritonitis (HP:0002586)2.03161894
78Hypoplasia of the odontoid process (HP:0003311)2.02890989
79Petechiae (HP:0000967)2.00908003
80Ovoid vertebral bodies (HP:0003300)2.00123163
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99910191
82Atrophic scars (HP:0001075)1.99216070
83Hypoplasia of the pons (HP:0012110)1.99091276
84Selective tooth agenesis (HP:0001592)1.98091939
85Large for gestational age (HP:0001520)1.97088423
86Patellar aplasia (HP:0006443)1.96232974
87Blue sclerae (HP:0000592)1.95605718
88Ketosis (HP:0001946)1.95435788
89Neonatal short-limb short stature (HP:0008921)1.95063134
90Aortic valve stenosis (HP:0001650)1.94017650
91Testicular neoplasm (HP:0010788)1.91961849
92Epiphyseal dysplasia (HP:0002656)1.91379945
93Bradycardia (HP:0001662)1.90422416
94Abnormal tarsal ossification (HP:0008369)1.90385139
95Aplasia/Hypoplasia of the macula (HP:0008059)1.90182875
96J-shaped sella turcica (HP:0002680)1.89469532
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89279740
98Short 4th metacarpal (HP:0010044)1.89279740
99Abnormality of the odontoid process (HP:0003310)1.88860666
100Mitral valve prolapse (HP:0001634)1.88624219
101Abnormality of calcium-phosphate metabolism (HP:0100530)1.87226924
102Hypoglycemic seizures (HP:0002173)1.86716542
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85356796
104Growth hormone excess (HP:0000845)1.85076831
105Abnormality of the distal phalanges of the toes (HP:0010182)1.84990871
106Synostosis of carpal bones (HP:0005048)1.84873449
107Fragile skin (HP:0001030)1.84112702
108Loss of speech (HP:0002371)1.82988087
109Glucose intolerance (HP:0000833)1.82500736
110Abnormality of proline metabolism (HP:0010907)1.82396452
111Hydroxyprolinuria (HP:0003080)1.82396452
112Aplasia/Hypoplasia of the patella (HP:0006498)1.81289404
113Malnutrition (HP:0004395)1.80484171
114Short nail (HP:0001799)1.80109670
115Xanthomatosis (HP:0000991)1.80024863
116Aneurysm (HP:0002617)1.79094837
117Birth length less than 3rd percentile (HP:0003561)1.78803897
118Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76685960
119Spondylolisthesis (HP:0003302)1.76661660
120Colon cancer (HP:0003003)1.76463625
121Ependymoma (HP:0002888)1.76332588
122Flared iliac wings (HP:0002869)1.76280954
123Abnormality of macrophages (HP:0004311)1.76123075
124Late onset (HP:0003584)1.75813871
125Congenital sensorineural hearing impairment (HP:0008527)1.75745991
126Abnormality of dentin (HP:0010299)1.74041945
127Hyperlipoproteinemia (HP:0010980)1.73490306
128Spinal canal stenosis (HP:0003416)1.73384218
129Optic nerve coloboma (HP:0000588)1.72616654
130Trismus (HP:0000211)1.71877095
131Broad face (HP:0000283)1.71859290
132Cardiomegaly (HP:0001640)1.71812178
133Ventricular arrhythmia (HP:0004308)1.71589696
134Eczematoid dermatitis (HP:0000976)1.71015845
135Natal tooth (HP:0000695)1.70947367
136Spinal cord lesions (HP:0100561)1.70273541
137Syringomyelia (HP:0003396)1.70273541
138Hypoproteinemia (HP:0003075)1.70016529
139Hypoventilation (HP:0002791)1.70003956
140Microretrognathia (HP:0000308)1.69796073
141Gastrointestinal dysmotility (HP:0002579)1.69384655
142Abnormality of the acetabulum (HP:0003170)1.68364896
143Soft skin (HP:0000977)1.68107048
144Abnormality of the labia minora (HP:0012880)1.67927090
145Biconcave vertebral bodies (HP:0004586)1.67518815
146Abnormal albumin level (HP:0012116)1.67290980
147Hypoalbuminemia (HP:0003073)1.67290980
148Hand muscle atrophy (HP:0009130)1.65119391
149Patent foramen ovale (HP:0001655)1.64316987
150Wormian bones (HP:0002645)1.64046233
151Interstitial pulmonary disease (HP:0006530)1.63494032
152Persistence of primary teeth (HP:0006335)1.60523607
153Carpal synostosis (HP:0009702)1.59223827
154Autoimmune thrombocytopenia (HP:0001973)1.58989266
155Myositis (HP:0100614)1.58975011
156Mild short stature (HP:0003502)1.58515172
157Long toe (HP:0010511)1.57600819
158Osteolytic defects of the hand bones (HP:0009699)1.57320389
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.57320389
160Joint stiffness (HP:0001387)1.55864177
161Abnormality of oral frenula (HP:0000190)1.54992812
162Right ventricular cardiomyopathy (HP:0011663)1.54667937
163Abnormality of the pons (HP:0007361)1.54105748
164Platyspondyly (HP:0000926)1.53293169
165Joint laxity (HP:0001388)1.51742435
166Pustule (HP:0200039)1.51033780
167Agnosia (HP:0010524)1.51006614
168Slender long bone (HP:0003100)1.50328996
169Camptodactyly of toe (HP:0001836)1.49679031
170Biliary tract neoplasm (HP:0100574)1.48240713
171Mucopolysacchariduria (HP:0008155)1.47967186
172Urinary glycosaminoglycan excretion (HP:0003541)1.47967186
173Mesomelia (HP:0003027)1.45121401
174Decreased skull ossification (HP:0004331)1.44605519
175Coxa valga (HP:0002673)1.42609154
176Irregular vertebral endplates (HP:0003301)1.41807722
177Preauricular pit (HP:0004467)1.41104399
178Periauricular skin pits (HP:0100277)1.41104399
179Enlarged penis (HP:0000040)1.40811785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.22287296
2FRK4.89021881
3EIF2AK34.12581830
4KSR13.43340129
5EPHB23.32314260
6NTRK13.14845761
7BCR2.85154383
8TESK12.65951246
9MAP4K22.36990877
10BUB12.29838798
11MYLK2.15664704
12MAP3K102.13529409
13GRK12.08535337
14PRKD22.00855937
15AKT31.96923924
16EPHB11.91827701
17FGFR21.91073806
18MAP2K61.84740988
19TNK21.77470006
20TRIB31.74442155
21PHKG21.71112671
22PHKG11.71112671
23TGFBR21.70518144
24HIPK21.70341389
25TRPM71.67196337
26PRKG21.61840784
27DAPK21.58895760
28LMTK21.56228854
29PTK2B1.55867241
30EPHA21.51780783
31CHUK1.45950491
32ERN11.42421489
33STK101.42326694
34CDC42BPA1.40039574
35ZAP701.37908791
36PIM21.36949326
37KDR1.31155021
38PAK41.30424390
39STK381.28049936
40EIF2AK11.27053403
41LIMK11.26352971
42MAP4K11.23685225
43TXK1.20911245
44SCYL21.17506813
45BRSK21.16320669
46JAK31.16171067
47TGFBR11.15534686
48MAPKAPK31.15361822
49FLT31.13386224
50PKN21.13079266
51PRKCE1.12935213
52TSSK61.12844310
53ADRBK21.12806514
54LRRK21.09538204
55WEE11.04421546
56TTN1.02606343
57ROCK10.99126975
58PASK0.98186021
59INSRR0.96803292
60MAP3K20.96584655
61MAP3K30.95316571
62RPS6KA40.93591049
63CAMK2D0.92179531
64BCKDK0.90762196
65PDGFRA0.85554802
66MAP3K140.85369137
67FGFR30.84834841
68PRKD10.84237282
69KIT0.83958839
70ROCK20.82750350
71EPHA30.81178239
72ZAK0.80375768
73IRAK40.78688199
74NUAK10.78635052
75IKBKB0.78249615
76MAPKAPK20.77142851
77SIK10.76649262
78RPS6KB20.76589514
79MAP2K10.76464911
80ILK0.76433131
81BTK0.75414685
82ADRBK10.74039252
83DAPK10.73830660
84GSK3A0.73232566
85MATK0.73180585
86STK240.71790063
87VRK20.71762156
88ERBB20.71371809
89PINK10.70067221
90PTK20.69956348
91BRSK10.68764446
92STK40.65859190
93NEK10.65634465
94PAK20.63732155
95IRAK30.63496893
96GRK60.62963840
97RPS6KA20.62019467
98DMPK0.61403559
99CSF1R0.61185237
100PIM10.60756510
101NTRK30.60616634
102PLK10.60328210
103TYK20.60323559
104NLK0.59521796
105STK38L0.59451608
106PIK3CG0.58841862
107DAPK30.57421721
108TAOK30.57217013
109EEF2K0.56689120
110NTRK20.55842000
111PTK60.55614393
112MAP3K10.53574109
113STK390.51805764
114OXSR10.51526340
115NME20.51032547
116MAP2K30.50397436
117PAK10.50071313
118EIF2AK20.50032770
119ERBB30.49572054
120PRKCI0.48546280
121ITK0.48050184
122MAPK70.47834736
123PAK60.47685354
124SMG10.47656859
125IKBKE0.46793617
126MTOR0.46720540
127NEK90.46476789
128PRKAA20.45682542
129MINK10.45126240
130MUSK0.44414969
131MST40.44139020
132PRKD30.43921289
133FGFR40.43667890
134PRKCH0.43565107
135MET0.43343991
136ACVR1B0.43305009
137WNK40.43283956
138PAK30.42298620
139ABL20.42250962
140FGFR10.42206242
141CDK80.41737503
142GRK50.41643315
143PRKCQ0.40807416
144TBK10.40555252
145AURKB0.40062139
146ATR0.38986177
147ABL10.38636182
148TIE10.38613769
149FER0.38127318
150TAOK10.37956713
151MAP3K120.36851290
152PLK30.36388621
153DDR20.36289360
154CCNB10.35806173
155NEK20.35540260
156OBSCN0.35242829
157CDK70.34476066
158JAK10.34359295
159STK30.33390059
160EGFR0.31693722

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.35985369
2Other glycan degradation_Homo sapiens_hsa005112.69372279
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.47822029
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.99336777
5Insulin secretion_Homo sapiens_hsa049111.96128757
6Sulfur metabolism_Homo sapiens_hsa009201.92933816
7Sphingolipid metabolism_Homo sapiens_hsa006001.89803002
8Proteasome_Homo sapiens_hsa030501.84791076
9Fatty acid elongation_Homo sapiens_hsa000621.82455059
10Type I diabetes mellitus_Homo sapiens_hsa049401.78089826
11Shigellosis_Homo sapiens_hsa051311.72654903
12Cell cycle_Homo sapiens_hsa041101.71513828
13Chronic myeloid leukemia_Homo sapiens_hsa052201.70525387
14DNA replication_Homo sapiens_hsa030301.69214112
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69168112
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68506683
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65258147
18Adherens junction_Homo sapiens_hsa045201.60597489
19Vitamin B6 metabolism_Homo sapiens_hsa007501.60252799
20Collecting duct acid secretion_Homo sapiens_hsa049661.56452100
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55363031
22Vibrio cholerae infection_Homo sapiens_hsa051101.50679989
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49382489
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40670703
25Focal adhesion_Homo sapiens_hsa045101.39311253
26Base excision repair_Homo sapiens_hsa034101.37033723
27Bladder cancer_Homo sapiens_hsa052191.36987462
28N-Glycan biosynthesis_Homo sapiens_hsa005101.36701999
29Hippo signaling pathway_Homo sapiens_hsa043901.35955419
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.34771793
31Antigen processing and presentation_Homo sapiens_hsa046121.34452174
32Protein export_Homo sapiens_hsa030601.29747448
33Small cell lung cancer_Homo sapiens_hsa052221.28467013
34Pancreatic cancer_Homo sapiens_hsa052121.28349502
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.28339514
36HTLV-I infection_Homo sapiens_hsa051661.26865359
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25456888
38Renin secretion_Homo sapiens_hsa049241.24801555
39Viral myocarditis_Homo sapiens_hsa054161.24302760
40Proteoglycans in cancer_Homo sapiens_hsa052051.24084612
41p53 signaling pathway_Homo sapiens_hsa041151.23078294
42Leishmaniasis_Homo sapiens_hsa051401.22926354
43Endometrial cancer_Homo sapiens_hsa052131.21315087
44RNA transport_Homo sapiens_hsa030131.21264215
45Mismatch repair_Homo sapiens_hsa034301.19688113
46Epstein-Barr virus infection_Homo sapiens_hsa051691.18153789
47MicroRNAs in cancer_Homo sapiens_hsa052061.17598837
48Butanoate metabolism_Homo sapiens_hsa006501.16871691
49Colorectal cancer_Homo sapiens_hsa052101.16248887
50Measles_Homo sapiens_hsa051621.15926596
51Folate biosynthesis_Homo sapiens_hsa007901.15893968
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15450130
53Legionellosis_Homo sapiens_hsa051341.14371260
54Hepatitis B_Homo sapiens_hsa051611.13960584
55Apoptosis_Homo sapiens_hsa042101.13324620
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13096513
57Primary immunodeficiency_Homo sapiens_hsa053401.11761487
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.10533886
59Notch signaling pathway_Homo sapiens_hsa043301.08619177
60Mineral absorption_Homo sapiens_hsa049781.08153120
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05859369
62Thyroid cancer_Homo sapiens_hsa052161.04938670
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03676055
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03383454
65Spliceosome_Homo sapiens_hsa030401.01816007
66Arachidonic acid metabolism_Homo sapiens_hsa005901.01295668
67Toxoplasmosis_Homo sapiens_hsa051451.00670749
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.99968465
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99785713
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99550690
71Regulation of autophagy_Homo sapiens_hsa041400.97804196
72Acute myeloid leukemia_Homo sapiens_hsa052210.97373827
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96724385
74Ether lipid metabolism_Homo sapiens_hsa005650.95333653
75Salivary secretion_Homo sapiens_hsa049700.93050099
76ECM-receptor interaction_Homo sapiens_hsa045120.93012742
77Glutathione metabolism_Homo sapiens_hsa004800.92269826
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92262385
79TGF-beta signaling pathway_Homo sapiens_hsa043500.92082270
80Basal cell carcinoma_Homo sapiens_hsa052170.91944043
81Viral carcinogenesis_Homo sapiens_hsa052030.91389418
82Herpes simplex infection_Homo sapiens_hsa051680.90999742
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.90624677
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.90209615
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89471432
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88659825
87Prolactin signaling pathway_Homo sapiens_hsa049170.88491925
88TNF signaling pathway_Homo sapiens_hsa046680.87630864
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87426215
90ABC transporters_Homo sapiens_hsa020100.85689990
91Lysosome_Homo sapiens_hsa041420.85503553
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85494457
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85352115
94Pathways in cancer_Homo sapiens_hsa052000.84770284
95T cell receptor signaling pathway_Homo sapiens_hsa046600.83954674
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83535231
97Non-small cell lung cancer_Homo sapiens_hsa052230.83016137
98HIF-1 signaling pathway_Homo sapiens_hsa040660.82271275
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81971636
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81950369
101Prostate cancer_Homo sapiens_hsa052150.81670392
102Influenza A_Homo sapiens_hsa051640.81411349
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80667853
104Peroxisome_Homo sapiens_hsa041460.80034241
105Nucleotide excision repair_Homo sapiens_hsa034200.79968265
106Glioma_Homo sapiens_hsa052140.79741776
107Salmonella infection_Homo sapiens_hsa051320.79118307
108Protein digestion and absorption_Homo sapiens_hsa049740.78625836
109Tryptophan metabolism_Homo sapiens_hsa003800.77894155
110Dilated cardiomyopathy_Homo sapiens_hsa054140.76150357
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75448939
112Circadian rhythm_Homo sapiens_hsa047100.75255414
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74866237
114Renal cell carcinoma_Homo sapiens_hsa052110.74699964
115Osteoclast differentiation_Homo sapiens_hsa043800.74461520
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74039193
117Glucagon signaling pathway_Homo sapiens_hsa049220.73955096
118Dorso-ventral axis formation_Homo sapiens_hsa043200.71084034
119RNA polymerase_Homo sapiens_hsa030200.71009015
120Pyrimidine metabolism_Homo sapiens_hsa002400.71005040
121Amoebiasis_Homo sapiens_hsa051460.70704670
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70392470
123Chemokine signaling pathway_Homo sapiens_hsa040620.70073864
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69925513
125Ovarian steroidogenesis_Homo sapiens_hsa049130.68697439
126Complement and coagulation cascades_Homo sapiens_hsa046100.68687494
127Circadian entrainment_Homo sapiens_hsa047130.68402968
128Pancreatic secretion_Homo sapiens_hsa049720.67878847
129Rheumatoid arthritis_Homo sapiens_hsa053230.67011080
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66699524
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.66201882
132Melanoma_Homo sapiens_hsa052180.65992748
133Hematopoietic cell lineage_Homo sapiens_hsa046400.64894670
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.64608264
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64183867
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64011975
137beta-Alanine metabolism_Homo sapiens_hsa004100.63460645
138Endocytosis_Homo sapiens_hsa041440.63024476
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62735264
140Tight junction_Homo sapiens_hsa045300.62096107
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.61728392
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61587216
143Platelet activation_Homo sapiens_hsa046110.60697152
144FoxO signaling pathway_Homo sapiens_hsa040680.60070012
145Insulin resistance_Homo sapiens_hsa049310.59007476
146Galactose metabolism_Homo sapiens_hsa000520.58956377
147Allograft rejection_Homo sapiens_hsa053300.58245727
148Rap1 signaling pathway_Homo sapiens_hsa040150.57781622
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57548846
150Linoleic acid metabolism_Homo sapiens_hsa005910.56564281
151Thyroid hormone synthesis_Homo sapiens_hsa049180.56390566
152Hedgehog signaling pathway_Homo sapiens_hsa043400.55913432
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55888343
154Phagosome_Homo sapiens_hsa041450.55116998
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.52758004
156Gastric acid secretion_Homo sapiens_hsa049710.52727841
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52668171
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52375645
159cAMP signaling pathway_Homo sapiens_hsa040240.50428145
160Synaptic vesicle cycle_Homo sapiens_hsa047210.50026597
161Malaria_Homo sapiens_hsa051440.49202081
162Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49132176
163Pertussis_Homo sapiens_hsa051330.47251213
164Histidine metabolism_Homo sapiens_hsa003400.46436827
165Selenocompound metabolism_Homo sapiens_hsa004500.44941146
166Serotonergic synapse_Homo sapiens_hsa047260.44447371
167Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43685153
168Cyanoamino acid metabolism_Homo sapiens_hsa004600.43557390
169Amphetamine addiction_Homo sapiens_hsa050310.41361513
170Inositol phosphate metabolism_Homo sapiens_hsa005620.41283862
171Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41244193
172Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40330074
173Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39775207
174Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38034790
175Calcium signaling pathway_Homo sapiens_hsa040200.37341625
176Phototransduction_Homo sapiens_hsa047440.37219850
177Type II diabetes mellitus_Homo sapiens_hsa049300.36910049

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