ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to kinetochore (GO:0034501)	5.77542918
2	mitotic chromosome condensation (GO:0007076)	5.59128991
3	mitotic sister chromatid segregation (GO:0000070)	5.26889669
4	sister chromatid segregation (GO:0000819)	5.25022147
5	mitotic sister chromatid cohesion (GO:0007064)	5.21430280
6	protein localization to chromosome, centromeric region (GO:0071459)	5.19130512
7	nuclear pore complex assembly (GO:0051292)	5.13388047
8	nuclear pore organization (GO:0006999)	4.96100735
9	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.95983129
10	DNA unwinding involved in DNA replication (GO:0006268)	4.92605524
11	mitotic metaphase plate congression (GO:0007080)	4.71044373
12	kinetochore organization (GO:0051383)	4.50621441
13	regulation of spindle organization (GO:0090224)	4.46176630
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.38288714
15	mitotic nuclear envelope disassembly (GO:0007077)	4.36487120
16	establishment of integrated proviral latency (GO:0075713)	4.24376739
17	metaphase plate congression (GO:0051310)	4.17724987
18	membrane disassembly (GO:0030397)	4.09152099
19	nuclear envelope disassembly (GO:0051081)	4.09152099
20	DNA ligation (GO:0006266)	4.03906545
21	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.02386384
22	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.02386384
23	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.02386384
24	regulation of mitotic spindle organization (GO:0060236)	4.02198033
25	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.99464711
26	pore complex assembly (GO:0046931)	3.99096149
27	positive regulation of chromosome segregation (GO:0051984)	3.98045788
28	regulation of sister chromatid cohesion (GO:0007063)	3.88674363
29	attachment of spindle microtubules to kinetochore (GO:0008608)	3.85325757
30	establishment of chromosome localization (GO:0051303)	3.85010050
31	protein localization to chromosome (GO:0034502)	3.83689738
32	meiotic chromosome segregation (GO:0045132)	3.79447006
33	chromosome condensation (GO:0030261)	3.71188104
34	DNA replication initiation (GO:0006270)	3.70472657
35	kinetochore assembly (GO:0051382)	3.70302984
36	DNA replication checkpoint (GO:0000076)	3.64437332
37	regulation of RNA export from nucleus (GO:0046831)	3.62521557
38	DNA replication-dependent nucleosome organization (GO:0034723)	3.60217092
39	DNA replication-dependent nucleosome assembly (GO:0006335)	3.60217092
40	chromosome segregation (GO:0007059)	3.59956003
41	DNA geometric change (GO:0032392)	3.58238996
42	DNA duplex unwinding (GO:0032508)	3.57390197
43	DNA strand elongation involved in DNA replication (GO:0006271)	3.54979095
44	regulation of chromosome segregation (GO:0051983)	3.54302112
45	heterochromatin organization (GO:0070828)	3.53849965
46	regulation of translational fidelity (GO:0006450)	3.52468926
47	chromatin assembly or disassembly (GO:0006333)	3.50441177
48	DNA replication-independent nucleosome assembly (GO:0006336)	3.46625354
49	DNA replication-independent nucleosome organization (GO:0034724)	3.46625354
50	protein complex localization (GO:0031503)	3.43810377
51	non-recombinational repair (GO:0000726)	3.42706604
52	double-strand break repair via nonhomologous end joining (GO:0006303)	3.42706604
53	negative regulation of histone methylation (GO:0031061)	3.41913948
54	formation of translation preinitiation complex (GO:0001731)	3.40063356
55	regulation of histone H3-K9 methylation (GO:0051570)	3.37462379
56	spindle checkpoint (GO:0031577)	3.36588996
57	DNA strand elongation (GO:0022616)	3.35767775
58	DNA topological change (GO:0006265)	3.35066030
59	CENP-A containing nucleosome assembly (GO:0034080)	3.34319396
60	chromatin remodeling at centromere (GO:0031055)	3.32440249
61	regulation of DNA endoreduplication (GO:0032875)	3.31614968
62	nuclear envelope organization (GO:0006998)	3.28462616
63	mitotic recombination (GO:0006312)	3.28408028
64	DNA packaging (GO:0006323)	3.27662822
65	regulation of centrosome duplication (GO:0010824)	3.27050596
66	DNA conformation change (GO:0071103)	3.26911068
67	regulation of centrosome cycle (GO:0046605)	3.26538844
68	ribosome assembly (GO:0042255)	3.23209879
69	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.22163815
70	dosage compensation (GO:0007549)	3.21936811
71	DNA synthesis involved in DNA repair (GO:0000731)	3.21299734
72	translesion synthesis (GO:0019985)	3.20980776
73	chromatin assembly (GO:0031497)	3.18200768
74	cellular protein complex localization (GO:0034629)	3.15985725
75	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.15654785
76	spindle assembly checkpoint (GO:0071173)	3.14933415
77	mRNA stabilization (GO:0048255)	3.14773692
78	RNA stabilization (GO:0043489)	3.14773692
79	monoubiquitinated protein deubiquitination (GO:0035520)	3.11941959
80	mitotic cytokinesis (GO:0000281)	3.10979131
81	negative regulation of chromosome segregation (GO:0051985)	3.10657285
82	telomere maintenance via semi-conservative replication (GO:0032201)	3.10078499
83	mitotic cell cycle (GO:0000278)	3.09609965
84	pre-miRNA processing (GO:0031054)	3.07921643
85	establishment of viral latency (GO:0019043)	3.07721851
86	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.07622579
87	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.07289905
88	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.05719211
89	telomere maintenance via recombination (GO:0000722)	3.05236176
90	telomere maintenance via telomere lengthening (GO:0010833)	3.03812900
91	regulation of mitotic sister chromatid segregation (GO:0033047)	3.03431277
92	regulation of sister chromatid segregation (GO:0033045)	3.03431277
93	regulation of mitotic sister chromatid separation (GO:0010965)	3.03431277
94	mitotic spindle organization (GO:0007052)	3.02467998
95	histone exchange (GO:0043486)	3.01775422
96	mitotic spindle assembly checkpoint (GO:0007094)	3.01456073
97	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.00897873
98	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.00897873
99	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.00897873
100	negative regulation of sister chromatid segregation (GO:0033046)	3.00897873
101	ATP-dependent chromatin remodeling (GO:0043044)	2.99836960
102	spindle organization (GO:0007051)	2.99792685
103	histone-serine phosphorylation (GO:0035404)	2.99479504
104	folic acid-containing compound biosynthetic process (GO:0009396)	2.99348029
105	mitotic spindle checkpoint (GO:0071174)	2.99045537
106	microtubule depolymerization (GO:0007019)	2.95439508
107	chromosome organization (GO:0051276)	2.94126137
108	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.93099891
109	sister chromatid cohesion (GO:0007062)	2.92759247
110	negative regulation of RNA splicing (GO:0033119)	2.87177485
111	regulation of centriole replication (GO:0046599)	2.84665420
112	mitotic DNA integrity checkpoint (GO:0044774)	2.81970569
113	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.81070098
114	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.79292468
115	regulation of nucleobase-containing compound transport (GO:0032239)	2.79229171
116	spindle assembly involved in mitosis (GO:0090307)	2.78395656
117	protein K6-linked ubiquitination (GO:0085020)	2.78102171
118	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.75141578
119	mitotic G2/M transition checkpoint (GO:0044818)	2.72692146

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* FOXM1_23109430_ChIP-Seq_U2OS_Human	7.26190436
2	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.49604375
3	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.11301422
4	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.56516045
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.97436904
6	AR_21909140_ChIP-Seq_LNCAP_Human	2.82725393
7	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.53845874
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.52705026
9	MYC_22102868_ChIP-Seq_BL_Human	2.51134039
10	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.46781165
11	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.20818070
12	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.07473042
13	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.04665276
14	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.03219407
15	E2F7_22180533_ChIP-Seq_HELA_Human	10.9188159
16	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.92716399
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.91303170
18	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.70810030
19	XRN2_22483619_ChIP-Seq_HELA_Human	1.69544945
20	VDR_21846776_ChIP-Seq_THP-1_Human	1.66025456
21	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.65555830
22	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.64725747
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.64173755
24	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.61773308
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.55852246
26	KDM5A_27292631_Chip-Seq_BREAST_Human	1.55368566
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50429749
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43687588
29	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.41825406
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.38865272
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.38257117
32	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.34236835
33	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.32226095
34	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31781946
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31404780
36	* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29388984
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.28642269
38	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.28050121
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26790784
40	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.25846521
41	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.24628696
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.23801944
43	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.22462596
44	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.20946009
45	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.20522517
46	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20085487
47	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.18792601
48	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18780667
49	TFEB_21752829_ChIP-Seq_HELA_Human	1.16003626
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.15658362
51	TCF7_22412390_ChIP-Seq_EML_Mouse	1.14852434
52	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.14632003
53	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12929437
54	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10854213
55	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.10331890
56	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.09839248
57	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09122947
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08686642
59	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.08264519
60	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07319450
61	UTX_26944678_Chip-Seq_JUKART_Human	1.05586489
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04976092
63	ZNF263_19887448_ChIP-Seq_K562_Human	1.04578932
64	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.04039606
65	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.02697741
66	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.02412210
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00540807
68	* SOX17_20123909_ChIP-Seq_XEN_Mouse	0.99886754
69	SPI1_23547873_ChIP-Seq_NB4_Human	0.99341444
70	* MYB_26560356_Chip-Seq_TH1_Human	0.98895362
71	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98778739
72	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98373798
73	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.98369196
74	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.98291841
75	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.97703671
76	MAF_26560356_Chip-Seq_TH1_Human	0.97387686
77	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.97321451
78	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.96755759
79	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.96548281
80	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96545901
81	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.96167622
82	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.95932137
83	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.95253071
84	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.94678311
85	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.94245841
86	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94201838
87	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93103642
88	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92832786
89	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.91953056
90	* MYB_26560356_Chip-Seq_TH2_Human	0.91110394
91	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.91065599
92	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90952989
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.89808948
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.89708819
95	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.88507335
96	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.88411988
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88252682
98	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87178093
99	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.87031823
100	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.86667381
101	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.84573096
102	VDR_24763502_ChIP-Seq_THP-1_Human	0.84158751
103	ATF3_27146783_Chip-Seq_COLON_Human	0.84007170
104	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.83728650
105	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.83498735
106	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.83003127
107	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.82117817
108	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.82070535
109	NCOR1_26117541_ChIP-Seq_K562_Human	0.82049375
110	KDM2B_26808549_Chip-Seq_DND41_Human	0.80415674
111	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.80140204
112	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.79953938
113	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.79808694
114	* NANOG_16153702_ChIP-ChIP_HESCs_Human	0.79338080
115	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.79065241
116	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.78967811
117	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.76503216
118	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.76131809
119	* SOX2_16153702_ChIP-ChIP_HESCs_Human	0.73689620
120	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.72626568
121	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.72561705
122	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.71140207
123	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.69385392
124	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.68143219

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.26500391
2	MP0003111_abnormal_nucleus_morphology	4.10596210
3	MP0010094_abnormal_chromosome_stability	4.00839999
4	MP0003077_abnormal_cell_cycle	3.63592394
5	MP0008057_abnormal_DNA_replication	3.41803770
6	MP0004957_abnormal_blastocyst_morpholog	3.24805111
7	MP0010307_abnormal_tumor_latency	2.69985014
8	MP0010352_gastrointestinal_tract_polyps	2.67568380
9	MP0005076_abnormal_cell_differentiation	2.44156660
10	MP0002396_abnormal_hematopoietic_system	2.42581020
11	MP0008007_abnormal_cellular_replicative	2.41178041
12	MP0001730_embryonic_growth_arrest	2.31085678
13	MP0000350_abnormal_cell_proliferation	2.28859915
14	MP0003705_abnormal_hypodermis_morpholog	2.20786782
15	MP0009697_abnormal_copulation	2.10441508
16	MP0003123_paternal_imprinting	2.02767141
17	MP0008058_abnormal_DNA_repair	1.99907046
18	MP0004808_abnormal_hematopoietic_stem	1.92998301
19	MP0001672_abnormal_embryogenesis/_devel	1.90381342
20	MP0005380_embryogenesis_phenotype	1.90381342
21	MP0008932_abnormal_embryonic_tissue	1.88403998
22	MP0003984_embryonic_growth_retardation	1.77917663
23	MP0001697_abnormal_embryo_size	1.75597440
24	MP0002088_abnormal_embryonic_growth/wei	1.74437158
25	MP0000569_abnormal_digit_pigmentation	1.72362487
26	MP0009278_abnormal_bone_marrow	1.72249832
27	MP0002084_abnormal_developmental_patter	1.67882463
28	MP0002085_abnormal_embryonic_tissue	1.64497991
29	MP0002009_preneoplasia	1.63345012
30	MP0000490_abnormal_crypts_of	1.63275245
31	MP0002086_abnormal_extraembryonic_tissu	1.61250021
32	MP0003121_genomic_imprinting	1.60490041
33	MP0004197_abnormal_fetal_growth/weight/	1.60243018
34	MP0003941_abnormal_skin_development	1.56522159
35	MP0002080_prenatal_lethality	1.50155115
36	MP0005397_hematopoietic_system_phenotyp	1.49390719
37	MP0001545_abnormal_hematopoietic_system	1.49390719
38	MP0008877_abnormal_DNA_methylation	1.48280205
39	MP0003567_abnormal_fetal_cardiomyocyte	1.42778192
40	MP0002019_abnormal_tumor_incidence	1.34237812
41	MP0003890_abnormal_embryonic-extraembry	1.33493784
42	MP0002877_abnormal_melanocyte_morpholog	1.28716571
43	MP0000313_abnormal_cell_death	1.28355134
44	MP0009053_abnormal_anal_canal	1.26588075
45	MP0001849_ear_inflammation	1.25716388
46	MP0000733_abnormal_muscle_development	1.23991894
47	MP0010030_abnormal_orbit_morphology	1.19313128
48	MP0004233_abnormal_muscle_weight	1.17648695
49	MP0003566_abnormal_cell_adhesion	1.17273973
50	MP0000703_abnormal_thymus_morphology	1.14080228
51	MP0002398_abnormal_bone_marrow	1.10456526
52	MP0003937_abnormal_limbs/digits/tail_de	1.09862220
53	MP0003950_abnormal_plasma_membrane	1.08918217
54	MP0009333_abnormal_splenocyte_physiolog	1.07028478
55	MP0001915_intracranial_hemorrhage	1.06884132
56	MP0006292_abnormal_olfactory_placode	1.06096085
57	MP0003303_peritoneal_inflammation	1.05106583
58	MP0009672_abnormal_birth_weight	1.02568509
59	MP0004185_abnormal_adipocyte_glucose	1.02393369
60	MP0005501_abnormal_skin_physiology	1.02377285
61	MP0000358_abnormal_cell_content/	1.00706217
62	MP0003300_gastrointestinal_ulcer	1.00501625
63	MP0009703_decreased_birth_body	0.99688373
64	MP0000537_abnormal_urethra_morphology	0.99233296
65	MP0001661_extended_life_span	0.98325933
66	MP0000428_abnormal_craniofacial_morphol	0.98132668
67	MP0003786_premature_aging	0.97763525
68	MP0002722_abnormal_immune_system	0.97023277
69	MP0005023_abnormal_wound_healing	0.96616503
70	MP0005621_abnormal_cell_physiology	0.93418728
71	MP0001293_anophthalmia	0.92939384
72	MP0006054_spinal_hemorrhage	0.92727488
73	MP0004264_abnormal_extraembryonic_tissu	0.91955836
74	MP0000689_abnormal_spleen_morphology	0.90790979
75	MP0003787_abnormal_imprinting	0.90682162
76	MP0003315_abnormal_perineum_morphology	0.87917647
77	MP0000432_abnormal_head_morphology	0.87617296
78	MP0003385_abnormal_body_wall	0.87393162
79	MP0002925_abnormal_cardiovascular_devel	0.86846298
80	MP0003935_abnormal_craniofacial_develop	0.85973361
81	MP0005623_abnormal_meninges_morphology	0.85585372
82	MP0000858_altered_metastatic_potential	0.85423156
83	MP0003763_abnormal_thymus_physiology	0.84273053
84	MP0005257_abnormal_intraocular_pressure	0.84151512
85	MP0001929_abnormal_gametogenesis	0.83729871
86	MP0002092_abnormal_eye_morphology	0.83316932
87	MP0002796_impaired_skin_barrier	0.82999122
88	MP0003448_altered_tumor_morphology	0.82933983
89	MP0003115_abnormal_respiratory_system	0.82577578
90	MP0002210_abnormal_sex_determination	0.81218163
91	MP0005384_cellular_phenotype	0.80349197
92	MP0003943_abnormal_hepatobiliary_system	0.78974959
93	MP0002166_altered_tumor_susceptibility	0.77448556
94	MP0002697_abnormal_eye_size	0.77241799
95	MP0006035_abnormal_mitochondrial_morpho	0.76245543
96	MP0002429_abnormal_blood_cell	0.75988181
97	MP0003861_abnormal_nervous_system	0.75922974
98	MP0003221_abnormal_cardiomyocyte_apopto	0.73085159
99	MP0002060_abnormal_skin_morphology	0.72262788
100	MP0002006_tumorigenesis	0.71765144
101	MP0000716_abnormal_immune_system	0.70923473
102	MP0001800_abnormal_humoral_immune	0.70401723
103	MP0001145_abnormal_male_reproductive	0.70128411
104	MP0000762_abnormal_tongue_morphology	0.69893597
105	MP0003755_abnormal_palate_morphology	0.68906942
106	MP0002111_abnormal_tail_morphology	0.68834791
107	MP0000477_abnormal_intestine_morphology	0.68647347
108	MP0003091_abnormal_cell_migration	0.67669590
109	MP0001119_abnormal_female_reproductive	0.65818208
110	MP0002233_abnormal_nose_morphology	0.65805404
111	MP0003699_abnormal_female_reproductive	0.65643455
112	MP0003119_abnormal_digestive_system	0.65113161
113	MP0003718_maternal_effect	0.64873457
114	MP0001346_abnormal_lacrimal_gland	0.64408302
115	MP0000383_abnormal_hair_follicle	0.64062618
116	MP0001286_abnormal_eye_development	0.63882025
117	MP0010234_abnormal_vibrissa_follicle	0.63427179
118	MP0008770_decreased_survivor_rate	0.63295922
119	MP0000653_abnormal_sex_gland	0.63149884
120	MP0001727_abnormal_embryo_implantation	0.63029420
121	MP0000627_abnormal_mammary_gland	0.62663899
122	MP0002452_abnormal_antigen_presenting	0.62176024
123	MP0005187_abnormal_penis_morphology	0.62054097
124	MP0000266_abnormal_heart_morphology	0.60964310
125	MP0002234_abnormal_pharynx_morphology	0.59567553
126	MP0001299_abnormal_eye_distance/	0.59278008
127	MP0004272_abnormal_basement_membrane	0.59195126
128	MP0002114_abnormal_axial_skeleton	0.58603160
129	MP0001881_abnormal_mammary_gland	0.58292690
130	MP0003942_abnormal_urinary_system	0.57795911
131	MP0002081_perinatal_lethality	0.57128632
132	MP0001216_abnormal_epidermal_layer	0.56619448
133	MP0002177_abnormal_outer_ear	0.56181843
134	MP0002938_white_spotting	0.55795742

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.80445859
2	Volvulus (HP:0002580)	3.67502547
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.50304015
4	Cortical dysplasia (HP:0002539)	3.44104740
5	Embryonal renal neoplasm (HP:0011794)	3.30082300
6	Abnormality of chromosome stability (HP:0003220)	3.09425455
7	Increased nuchal translucency (HP:0010880)	3.07961412
8	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.06941709
9	Short 4th metacarpal (HP:0010044)	3.06941709
10	Ectopic kidney (HP:0000086)	3.03196946
11	Abnormal lung lobation (HP:0002101)	2.95499616
12	Abnormality of the fingertips (HP:0001211)	2.90217122
13	Ependymoma (HP:0002888)	2.79608657
14	Deviation of the thumb (HP:0009603)	2.73233508
15	Impulsivity (HP:0100710)	2.71162920
16	Proximal placement of thumb (HP:0009623)	2.70079391
17	Meckel diverticulum (HP:0002245)	2.62719598
18	Patellar aplasia (HP:0006443)	2.62622997
19	Birth length less than 3rd percentile (HP:0003561)	2.60438961
20	Medulloblastoma (HP:0002885)	2.59461063
21	Prominent nose (HP:0000448)	2.57985460
22	Facial hemangioma (HP:0000329)	2.55935733
23	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.53284052
24	Long eyelashes (HP:0000527)	2.51321669
25	Myelodysplasia (HP:0002863)	2.51110560
26	Abnormality of the ileum (HP:0001549)	2.46587307
27	Abnormality of the preputium (HP:0100587)	2.44629256
28	Missing ribs (HP:0000921)	2.43295033
29	Aplasia/Hypoplasia of the patella (HP:0006498)	2.42819356
30	Selective tooth agenesis (HP:0001592)	2.33953602
31	Astrocytoma (HP:0009592)	2.32688842
32	Abnormality of the astrocytes (HP:0100707)	2.32688842
33	Small intestinal stenosis (HP:0012848)	2.31086551
34	Duodenal stenosis (HP:0100867)	2.31086551
35	Multiple enchondromatosis (HP:0005701)	2.26593970
36	Colon cancer (HP:0003003)	2.25609871
37	Abnormality of the carotid arteries (HP:0005344)	2.22679556
38	Cafe-au-lait spot (HP:0000957)	2.22082331
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.21806730
40	Rhabdomyosarcoma (HP:0002859)	2.18617064
41	High pitched voice (HP:0001620)	2.17801671
42	Microvesicular hepatic steatosis (HP:0001414)	2.17790695
43	Ankyloglossia (HP:0010296)	2.17041858
44	Embryonal neoplasm (HP:0002898)	2.10852021
45	Abnormality of the 4th metacarpal (HP:0010012)	2.10581680
46	Abnormality of the labia minora (HP:0012880)	2.10490628
47	Progressive external ophthalmoplegia (HP:0000590)	2.09563337
48	Choanal atresia (HP:0000453)	2.08422468
49	Agnosia (HP:0010524)	2.08101408
50	Gastrointestinal carcinoma (HP:0002672)	2.07610016
51	Malignant gastrointestinal tract tumors (HP:0006749)	2.07610016
52	Progressive muscle weakness (HP:0003323)	2.07605259
53	High anterior hairline (HP:0009890)	2.06776476
54	Breast hypoplasia (HP:0003187)	2.06329484
55	Neoplasm of the colon (HP:0100273)	2.04565870
56	Horseshoe kidney (HP:0000085)	2.02088652
57	Insomnia (HP:0100785)	2.01828283
58	Hyperacusis (HP:0010780)	2.01106660
59	Acute myeloid leukemia (HP:0004808)	2.01009698
60	Duplication of thumb phalanx (HP:0009942)	2.00451166
61	Atresia of the external auditory canal (HP:0000413)	1.99551266
62	Sparse lateral eyebrow (HP:0005338)	1.98981511
63	Heterotopia (HP:0002282)	1.97142205
64	Glioma (HP:0009733)	1.96742236
65	Termporal pattern (HP:0011008)	1.95966603
66	Insidious onset (HP:0003587)	1.95966603
67	Sloping forehead (HP:0000340)	1.95916563
68	Poikiloderma (HP:0001029)	1.93577732
69	Syringomyelia (HP:0003396)	1.92556281
70	Spinal cord lesions (HP:0100561)	1.92556281
71	Overlapping toe (HP:0001845)	1.91892775
72	Reticulocytopenia (HP:0001896)	1.91622179
73	Basal cell carcinoma (HP:0002671)	1.90837658
74	Abnormality of the duodenum (HP:0002246)	1.89837400
75	Neoplasm of the oral cavity (HP:0100649)	1.88748490
76	Abnormality of the fetal cardiovascular system (HP:0010948)	1.86956993
77	Abnormal umbilical cord blood vessels (HP:0011403)	1.86956993
78	Single umbilical artery (HP:0001195)	1.86956993
79	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.86871632
80	Abnormality of chromosome segregation (HP:0002916)	1.86434049
81	Cutis marmorata (HP:0000965)	1.85396365
82	Abnormality of the umbilical cord (HP:0010881)	1.85215339
83	Ulnar bowing (HP:0003031)	1.84776335
84	Triphalangeal thumb (HP:0001199)	1.84211413
85	Blepharitis (HP:0000498)	1.84160868
86	Abnormality of oral frenula (HP:0000190)	1.82307015
87	Broad thumb (HP:0011304)	1.82185064
88	11 pairs of ribs (HP:0000878)	1.82045336
89	Duplicated collecting system (HP:0000081)	1.81950138
90	Absent radius (HP:0003974)	1.81602395
91	Neoplasm of striated muscle (HP:0009728)	1.80289836
92	Tracheoesophageal fistula (HP:0002575)	1.79044114
93	Microglossia (HP:0000171)	1.79037277
94	Clubbing of toes (HP:0100760)	1.78471321
95	Deep philtrum (HP:0002002)	1.77777618
96	Squamous cell carcinoma (HP:0002860)	1.76559616
97	Sandal gap (HP:0001852)	1.76068808
98	Abnormal number of incisors (HP:0011064)	1.75946344
99	Orthostatic hypotension (HP:0001278)	1.75232990
100	Renal duplication (HP:0000075)	1.74733890
101	Cutaneous melanoma (HP:0012056)	1.73941858
102	Short thumb (HP:0009778)	1.73574704
103	Abnormality of DNA repair (HP:0003254)	1.73067861
104	Increased density of long bones (HP:0006392)	1.72224985
105	Trigonocephaly (HP:0000243)	1.70513940
106	Leiomyosarcoma (HP:0100243)	1.69513987
107	Uterine leiomyosarcoma (HP:0002891)	1.69513987
108	Urethral obstruction (HP:0000796)	1.69458919
109	Microtia (HP:0008551)	1.69272732
110	Absent thumb (HP:0009777)	1.68180801
111	Cellulitis (HP:0100658)	1.68071471
112	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.67671869
113	Osteolytic defects of the hand bones (HP:0009699)	1.67671869
114	Absent forearm bone (HP:0003953)	1.66329091
115	Aplasia involving forearm bones (HP:0009822)	1.66329091
116	Transitional cell carcinoma of the bladder (HP:0006740)	1.66194641
117	Arteriovenous malformation (HP:0100026)	1.66052401
118	Papillary thyroid carcinoma (HP:0002895)	1.65997663
119	Entropion (HP:0000621)	1.65707226
120	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.65183464
121	Lip pit (HP:0100267)	1.64996842
122	Bone marrow hypocellularity (HP:0005528)	1.64856079
123	Truncal obesity (HP:0001956)	1.64436267
124	Thrombocytosis (HP:0001894)	1.64346557
125	Skin tags (HP:0010609)	1.64049258
126	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.63770710
127	Neoplasm of the pancreas (HP:0002894)	1.63478244
128	Broad palm (HP:0001169)	1.62918758
129	Abnormality of glycolysis (HP:0004366)	1.62010232
130	Obsessive-compulsive behavior (HP:0000722)	1.61857314
131	Nephroblastoma (Wilms tumor) (HP:0002667)	1.61755051
132	Biliary tract neoplasm (HP:0100574)	1.61623850
133	Asymmetry of the thorax (HP:0001555)	1.61613298
134	Low anterior hairline (HP:0000294)	1.61293367
135	Overriding aorta (HP:0002623)	1.60522999
136	Broad phalanges of the hand (HP:0009768)	1.59893530
137	Capillary hemangiomas (HP:0005306)	1.59661518
138	Abnormality of cochlea (HP:0000375)	1.57431110
139	Abnormality of the calcaneus (HP:0008364)	1.55732074
140	Hypoplastic pelvis (HP:0008839)	1.54460701
141	Elfin facies (HP:0004428)	1.54369424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.76079695
2	CDK12	3.93599847
3	NEK2	3.63343526
4	LATS1	3.38339869
5	PBK	2.88653002
6	WEE1	2.66109214
7	EEF2K	2.59414489
8	BUB1	2.58963749
9	TTK	2.37619796
10	STK10	2.16260888
11	STK3	2.05385264
12	PKN2	1.99827747
13	MAP3K10	1.91367844
14	LATS2	1.89721025
15	NEK1	1.84076558
16	CDK4	1.80925292
17	AURKB	1.75369512
18	BRSK2	1.75096677
19	CHEK2	1.74324347
20	PLK1	1.69975183
21	TRIB3	1.66916637
22	PLK4	1.62080752
23	SRPK1	1.61739353
24	CDK6	1.59952577
25	SMG1	1.55294851
26	CDK7	1.54414951
27	ATR	1.50847099
28	TAF1	1.49266953
29	STK38L	1.49081751
30	MST1R	1.47198337
31	RPS6KB2	1.45340676
32	RPS6KA4	1.43732105
33	CHEK1	1.41492045
34	MAP3K8	1.39248480
35	STK4	1.33113817
36	ZAK	1.32579962
37	BRD4	1.28404619
38	PLK3	1.25395131
39	BRSK1	1.22769383
40	MKNK1	1.22305437
41	MELK	1.20923798
42	TESK2	1.19334923
43	VRK2	1.13961142
44	MST4	1.13473254
45	ERBB4	1.12197750
46	ATM	1.11489730
47	BRAF	1.11042074
48	PASK	1.08324766
49	EIF2AK1	1.06288824
50	PNCK	1.06251285
51	ICK	1.04790456
52	SCYL2	1.04686746
53	CAMK1D	1.02166687
54	ACVR1B	1.01804301
55	PAK4	1.01613729
56	MET	0.96950738
57	PIM1	0.96483409
58	MAP4K1	0.96215573
59	CDK8	0.96076887
60	CDK2	0.95566851
61	NME2	0.95417414
62	MTOR	0.95298403
63	ALK	0.94471420
64	EIF2AK2	0.93456881
65	LRRK2	0.89611561
66	MKNK2	0.87272022
67	DYRK3	0.85259710
68	TTN	0.84388770
69	AURKA	0.78077299
70	CDK1	0.76685479
71	IRAK3	0.72369348
72	TSSK6	0.71253429
73	TAOK1	0.64937295
74	PAK2	0.64001130
75	CDK9	0.62582193
76	CCNB1	0.61205478
77	PTK6	0.57577388
78	TGFBR1	0.55985161
79	PDGFRB	0.55243776
80	TRIM28	0.54243673
81	PDGFRA	0.51979185
82	EPHA2	0.51568289
83	CSF1R	0.50309475
84	TRPM7	0.50011405
85	MARK3	0.49215806
86	BMX	0.48706508
87	TLK1	0.47079919
88	CLK1	0.46911932
89	CAMK1G	0.46502230
90	PAK1	0.46330044
91	DMPK	0.45152562
92	MAPK14	0.44607859
93	JAK3	0.44563357
94	AKT2	0.44298180
95	CSNK1D	0.44172662
96	MAP3K9	0.43937214
97	CDK18	0.42967419
98	CDK15	0.42134144
99	CDK11A	0.41685621
100	FLT3	0.40945785
101	PRKDC	0.40252803
102	MAPK11	0.39646245
103	VRK1	0.38602310
104	PTK2	0.38060991
105	NEK9	0.37843014
106	GRK6	0.37113584
107	MAP2K3	0.36898203
108	NUAK1	0.36704876
109	AKT1	0.35473946
110	PRKCI	0.35059298
111	CDK14	0.34572730
112	SIK2	0.32697438
113	CSNK2A1	0.32318774
114	PRPF4B	0.31376070
115	MAP3K6	0.31215629
116	CSNK2A2	0.30364847
117	CHUK	0.30110559
118	MAPKAPK2	0.30106938
119	CSNK1E	0.29791348
120	TESK1	0.29142333
121	FGFR1	0.29092479
122	EIF2AK3	0.29038706
123	MAPK1	0.28822080
124	KSR1	0.27733966
125	RAF1	0.26980347
126	GSK3B	0.26553845
127	YES1	0.21816731

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.92009476
2	Cell cycle_Homo sapiens_hsa04110	3.37473895
3	Mismatch repair_Homo sapiens_hsa03430	3.21503996
4	RNA transport_Homo sapiens_hsa03013	2.81164537
5	Spliceosome_Homo sapiens_hsa03040	2.62496056
6	Homologous recombination_Homo sapiens_hsa03440	2.51444888
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.50778354
8	Base excision repair_Homo sapiens_hsa03410	2.39409880
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.28091106
10	p53 signaling pathway_Homo sapiens_hsa04115	2.11528403
11	One carbon pool by folate_Homo sapiens_hsa00670	2.06007189
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.03294927
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.96770666
14	mRNA surveillance pathway_Homo sapiens_hsa03015	1.96588905
15	MicroRNAs in cancer_Homo sapiens_hsa05206	1.67813901
16	RNA degradation_Homo sapiens_hsa03018	1.64175281
17	Proteasome_Homo sapiens_hsa03050	1.62783213
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.53562397
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.50386362
20	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.48504592
21	Small cell lung cancer_Homo sapiens_hsa05222	1.48128756
22	Viral carcinogenesis_Homo sapiens_hsa05203	1.47286197
23	Basal transcription factors_Homo sapiens_hsa03022	1.46975648
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38558745
25	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.36721127
26	Herpes simplex infection_Homo sapiens_hsa05168	1.30660329
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.23854449
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23040226
29	RNA polymerase_Homo sapiens_hsa03020	1.22329633
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.21539195
31	HTLV-I infection_Homo sapiens_hsa05166	1.21091232
32	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.17137088
33	Pancreatic cancer_Homo sapiens_hsa05212	1.16231266
34	Colorectal cancer_Homo sapiens_hsa05210	1.15434465
35	Oocyte meiosis_Homo sapiens_hsa04114	1.15154009
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12839499
37	Lysine degradation_Homo sapiens_hsa00310	1.11144169
38	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.09928990
39	Hepatitis B_Homo sapiens_hsa05161	1.06054015
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.05834082
41	Non-small cell lung cancer_Homo sapiens_hsa05223	1.03551205
42	mTOR signaling pathway_Homo sapiens_hsa04150	1.02514597
43	Viral myocarditis_Homo sapiens_hsa05416	1.01125728
44	Thyroid cancer_Homo sapiens_hsa05216	0.99964608
45	Adherens junction_Homo sapiens_hsa04520	0.99649396
46	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.97266880
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95003095
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.92933835
49	Carbon metabolism_Homo sapiens_hsa01200	0.92750556
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.92726628
51	Apoptosis_Homo sapiens_hsa04210	0.92610436
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.92447860
53	Prostate cancer_Homo sapiens_hsa05215	0.92386392
54	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.92005770
55	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.91903601
56	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.90556241
57	Ribosome_Homo sapiens_hsa03010	0.88442935
58	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.87024477
59	Bladder cancer_Homo sapiens_hsa05219	0.86503563
60	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84349401
61	Notch signaling pathway_Homo sapiens_hsa04330	0.84119428
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.81344550
63	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81278850
64	Shigellosis_Homo sapiens_hsa05131	0.80924196
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.80459832
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.80438099
67	Proteoglycans in cancer_Homo sapiens_hsa05205	0.80314187
68	Measles_Homo sapiens_hsa05162	0.76846029
69	Endometrial cancer_Homo sapiens_hsa05213	0.76753591
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.75572944
71	Acute myeloid leukemia_Homo sapiens_hsa05221	0.74738243
72	Leishmaniasis_Homo sapiens_hsa05140	0.73537488
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.72591168
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72056648
75	FoxO signaling pathway_Homo sapiens_hsa04068	0.70609409
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.69301205
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.67893202
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.66643084
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.66285150
80	Pathways in cancer_Homo sapiens_hsa05200	0.65863558
81	Influenza A_Homo sapiens_hsa05164	0.65415146
82	Folate biosynthesis_Homo sapiens_hsa00790	0.65396218
83	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.64908166
84	Protein export_Homo sapiens_hsa03060	0.62902713
85	Glioma_Homo sapiens_hsa05214	0.62646133
86	Legionellosis_Homo sapiens_hsa05134	0.61859636
87	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.61458693
88	Renal cell carcinoma_Homo sapiens_hsa05211	0.60745443
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.60681523
90	Toxoplasmosis_Homo sapiens_hsa05145	0.59576890
91	Melanoma_Homo sapiens_hsa05218	0.59561128
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58350077
93	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57774920
94	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.57308528
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.56963571
96	Osteoclast differentiation_Homo sapiens_hsa04380	0.55497546
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.55364742
98	VEGF signaling pathway_Homo sapiens_hsa04370	0.54635942
99	Focal adhesion_Homo sapiens_hsa04510	0.53050921
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52326834
101	Prolactin signaling pathway_Homo sapiens_hsa04917	0.50169653
102	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.47682071
103	Platelet activation_Homo sapiens_hsa04611	0.46559784
104	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.46381516
105	TNF signaling pathway_Homo sapiens_hsa04668	0.43724517
106	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.43211146
107	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42842879
108	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41883904
109	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40656231
110	Purine metabolism_Homo sapiens_hsa00230	0.39844429
111	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38353004
112	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38214466
113	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.38162936
114	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.37931061
115	Tuberculosis_Homo sapiens_hsa05152	0.37852549
116	Alcoholism_Homo sapiens_hsa05034	0.37008972
117	Selenocompound metabolism_Homo sapiens_hsa00450	0.36784636
118	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36490447
119	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.36064866
120	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.35794483
121	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.35718312
122	Sulfur relay system_Homo sapiens_hsa04122	0.32507447
123	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.31723479
124	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30454339
125	ErbB signaling pathway_Homo sapiens_hsa04012	0.28783259
126	Tight junction_Homo sapiens_hsa04530	0.27701948
127	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.26655795
128	Glutathione metabolism_Homo sapiens_hsa00480	0.25921267
129	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.25704086
130	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24423885
131	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.24388874
132	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24357996
133	Galactose metabolism_Homo sapiens_hsa00052	0.20730772
134	AMPK signaling pathway_Homo sapiens_hsa04152	0.19852897

ARHGAP11A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »