ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	meiotic chromosome segregation (GO:0045132)	6.00489688
2	sister chromatid segregation (GO:0000819)	5.94111651
3	mitotic sister chromatid segregation (GO:0000070)	5.87687978
4	kinetochore organization (GO:0051383)	5.31214489
5	mitotic chromosome condensation (GO:0007076)	5.10967433
6	microtubule depolymerization (GO:0007019)	5.00129743
7	nuclear pore complex assembly (GO:0051292)	4.87445180
8	mitotic sister chromatid cohesion (GO:0007064)	4.84763029
9	replication fork processing (GO:0031297)	4.58208867
10	regulation of centriole replication (GO:0046599)	4.58195723
11	DNA topological change (GO:0006265)	4.57709417
12	nuclear pore organization (GO:0006999)	4.45799899
13	DNA double-strand break processing (GO:0000729)	4.35252010
14	kinetochore assembly (GO:0051382)	4.33047646
15	regulation of DNA endoreduplication (GO:0032875)	4.30476003
16	centriole replication (GO:0007099)	4.26750917
17	protein localization to chromosome, centromeric region (GO:0071459)	4.24780355
18	protein localization to kinetochore (GO:0034501)	4.24334928
19	DNA replication checkpoint (GO:0000076)	4.14195234
20	regulation of centrosome cycle (GO:0046605)	4.13989242
21	mitotic metaphase plate congression (GO:0007080)	4.12659746
22	DNA unwinding involved in DNA replication (GO:0006268)	4.10575713
23	chromosome condensation (GO:0030261)	4.08927011
24	chromatin remodeling at centromere (GO:0031055)	4.08791230
25	CENP-A containing nucleosome assembly (GO:0034080)	4.08629638
26	DNA strand elongation involved in DNA replication (GO:0006271)	4.02876123
27	DNA replication initiation (GO:0006270)	4.01922322
28	monoubiquitinated protein deubiquitination (GO:0035520)	3.95045704
29	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.93653086
30	regulation of centrosome duplication (GO:0010824)	3.91788440
31	telomere maintenance via semi-conservative replication (GO:0032201)	3.91470293
32	DNA ligation (GO:0006266)	3.91281021
33	metaphase plate congression (GO:0051310)	3.90802588
34	DNA strand elongation (GO:0022616)	3.90733345
35	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.89528845
36	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.89528845
37	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.89528845
38	double-strand break repair via homologous recombination (GO:0000724)	3.88718870
39	recombinational repair (GO:0000725)	3.88054102
40	microtubule polymerization or depolymerization (GO:0031109)	3.87022421
41	histone exchange (GO:0043486)	3.85355831
42	pore complex assembly (GO:0046931)	3.80262471
43	mitotic recombination (GO:0006312)	3.79441699
44	attachment of spindle microtubules to kinetochore (GO:0008608)	3.79035341
45	chromosome segregation (GO:0007059)	3.78730584
46	DNA packaging (GO:0006323)	3.72441607
47	telomere maintenance via recombination (GO:0000722)	3.66823292
48	mitotic nuclear envelope disassembly (GO:0007077)	3.65481215
49	centrosome organization (GO:0051297)	3.65189814
50	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.61209189
51	DNA conformation change (GO:0071103)	3.48842591
52	sister chromatid cohesion (GO:0007062)	3.46364854
53	spindle checkpoint (GO:0031577)	3.45810686
54	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.43681341
55	microtubule organizing center organization (GO:0031023)	3.43278882
56	DNA synthesis involved in DNA repair (GO:0000731)	3.41641774
57	DNA geometric change (GO:0032392)	3.41417147
58	protein K6-linked ubiquitination (GO:0085020)	3.40907927
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.38884068
60	negative regulation of chromosome segregation (GO:0051985)	3.38299656
61	DNA duplex unwinding (GO:0032508)	3.37291703
62	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.36075947
63	nuclear envelope disassembly (GO:0051081)	3.34937903
64	membrane disassembly (GO:0030397)	3.34937903
65	regulation of mitotic sister chromatid separation (GO:0010965)	3.34780194
66	regulation of mitotic sister chromatid segregation (GO:0033047)	3.34780194
67	regulation of sister chromatid segregation (GO:0033045)	3.34780194
68	centriole assembly (GO:0098534)	3.34693615
69	double-strand break repair via nonhomologous end joining (GO:0006303)	3.34399377
70	non-recombinational repair (GO:0000726)	3.34399377
71	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.33561118
72	regulation of spindle organization (GO:0090224)	3.32523822
73	regulation of chromosome segregation (GO:0051983)	3.31370728
74	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.31241960
75	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.31241960
76	DNA replication-dependent nucleosome assembly (GO:0006335)	3.30241857
77	DNA replication-dependent nucleosome organization (GO:0034723)	3.30241857
78	positive regulation of chromosome segregation (GO:0051984)	3.29473939
79	histone-serine phosphorylation (GO:0035404)	3.26096232
80	mitotic spindle checkpoint (GO:0071174)	3.23651674
81	centrosome duplication (GO:0051298)	3.23346776
82	protein localization to chromosome (GO:0034502)	3.23254322
83	establishment of chromosome localization (GO:0051303)	3.21492897
84	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.18892559
85	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.18892559
86	negative regulation of sister chromatid segregation (GO:0033046)	3.18892559
87	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.18892559
88	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.18892559
89	double-strand break repair (GO:0006302)	3.18615457
90	regulation of mitotic spindle organization (GO:0060236)	3.18615078
91	DNA replication-independent nucleosome organization (GO:0034724)	3.16686085
92	DNA replication-independent nucleosome assembly (GO:0006336)	3.16686085
93	translesion synthesis (GO:0019985)	3.14703460
94	regulation of sister chromatid cohesion (GO:0007063)	3.13145656
95	mitotic spindle assembly checkpoint (GO:0007094)	3.12999431
96	V(D)J recombination (GO:0033151)	3.12213128
97	regulation of histone H3-K9 methylation (GO:0051570)	3.11949064
98	spindle assembly checkpoint (GO:0071173)	3.11740428
99	spindle assembly (GO:0051225)	3.11459866
100	DNA recombination (GO:0006310)	3.07272917

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.95126367
2	* FOXM1_23109430_ChIP-Seq_U2OS_Human	6.76853873
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	5.24102681
4	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.12923290
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.48436643
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.06928811
7	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.69541454
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.68513514
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55499955
10	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.47180954
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.07228496
12	EWS_26573619_Chip-Seq_HEK293_Human	2.03293830
13	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99254804
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.99041627
15	AR_21909140_ChIP-Seq_LNCAP_Human	1.94614164
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92845879
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.89747864
18	FUS_26573619_Chip-Seq_HEK293_Human	1.75535494
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73287302
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.70307709
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68601062
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66967371
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.65720143
24	VDR_22108803_ChIP-Seq_LS180_Human	1.64819477
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64277432
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.60535640
27	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.58067025
28	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.56092706
29	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.55630627
30	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.55122102
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.54623447
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53896086
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.50416334
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.50268161
35	GATA1_22025678_ChIP-Seq_K562_Human	1.48519501
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46014376
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.44822766
38	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.43632074
39	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.42998372
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36153143
41	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35285679
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.33533927
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32998286
44	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31828229
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31576396
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.28696408
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23415974
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22847763
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.21703437
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.21238125
51	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.18276878
52	SCL_19346495_ChIP-Seq_HPC-7_Human	1.17482098
53	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.16395754
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16156412
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.13302696
56	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12522941
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.12223977
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.08827439
59	* STAT3_23295773_ChIP-Seq_U87_Human	1.06884426
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06361058
61	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.03069713
62	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02756090
63	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.99861642
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99749344
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99010694
66	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96550506
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92737996
68	GABP_19822575_ChIP-Seq_HepG2_Human	0.92621730
69	P300_19829295_ChIP-Seq_ESCs_Human	0.90681338
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.89881476
71	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89725019
72	TCF4_23295773_ChIP-Seq_U87_Human	0.88110028
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.87334237
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.87152076
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86687268
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85383942
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.85383942
78	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.85220293
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84992450
80	CBP_20019798_ChIP-Seq_JUKART_Human	0.84992450
81	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.81633896
82	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.80887253
83	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.80073614
84	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.80008756
85	SOX9_26525672_Chip-Seq_HEART_Mouse	0.79741558
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.79419416
87	AR_21572438_ChIP-Seq_LNCaP_Human	0.76693785
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.76124847
89	* MYB_26560356_Chip-Seq_TH2_Human	0.75741208
90	TP53_22573176_ChIP-Seq_HFKS_Human	0.75536417
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.73569868
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.72959336
93	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.71647194
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.71601405
95	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.70733244
96	XRN2_22483619_ChIP-Seq_HELA_Human	0.69538192
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.68284108
98	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.64823208
99	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.64781690
100	GATA3_26560356_Chip-Seq_TH1_Human	0.64065942

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	6.07693816
2	MP0010094_abnormal_chromosome_stability	5.69262781
3	MP0003111_abnormal_nucleus_morphology	4.25359159
4	MP0003693_abnormal_embryo_hatching	4.15004417
5	MP0008058_abnormal_DNA_repair	3.71618314
6	MP0003077_abnormal_cell_cycle	3.55276434
7	MP0000569_abnormal_digit_pigmentation	3.45234902
8	MP0004957_abnormal_blastocyst_morpholog	2.87199286
9	MP0009697_abnormal_copulation	2.76669875
10	MP0008007_abnormal_cellular_replicative	2.17725319
11	MP0008932_abnormal_embryonic_tissue	2.13733700
12	MP0003718_maternal_effect	2.12457332
13	MP0006292_abnormal_olfactory_placode	2.07663705
14	MP0002396_abnormal_hematopoietic_system	2.06867942
15	MP0010307_abnormal_tumor_latency	1.94798601
16	MP0002009_preneoplasia	1.81585663
17	MP0003786_premature_aging	1.74038208
18	MP0008877_abnormal_DNA_methylation	1.72549989
19	MP0001929_abnormal_gametogenesis	1.62672685
20	MP0000015_abnormal_ear_pigmentation	1.61599007
21	MP0004147_increased_porphyrin_level	1.61021035
22	MP0004808_abnormal_hematopoietic_stem	1.53799701
23	MP0005174_abnormal_tail_pigmentation	1.53676575
24	MP0002210_abnormal_sex_determination	1.45039821
25	MP0003950_abnormal_plasma_membrane	1.43018263
26	MP0000350_abnormal_cell_proliferation	1.39489633
27	MP0000372_irregular_coat_pigmentation	1.37057488
28	MP0003698_abnormal_male_reproductive	1.33927605
29	MP0000427_abnormal_hair_cycle	1.32766322
30	MP0002095_abnormal_skin_pigmentation	1.28745689
31	MP0001697_abnormal_embryo_size	1.28519325
32	MP0008995_early_reproductive_senescence	1.24281678
33	MP0001145_abnormal_male_reproductive	1.23086052
34	MP0003937_abnormal_limbs/digits/tail_de	1.20370610
35	MP0001672_abnormal_embryogenesis/_devel	1.18254367
36	MP0005380_embryogenesis_phenotype	1.18254367
37	MP0000653_abnormal_sex_gland	1.17624773
38	MP0000313_abnormal_cell_death	1.14811917
39	MP0003943_abnormal_hepatobiliary_system	1.14292499
40	MP0008961_abnormal_basal_metabolism	1.14095092
41	MP0000383_abnormal_hair_follicle	1.13848506
42	MP0004197_abnormal_fetal_growth/weight/	1.13548062
43	MP0002938_white_spotting	1.13398507
44	MP0005076_abnormal_cell_differentiation	1.12179525
45	MP0002019_abnormal_tumor_incidence	1.10784096
46	MP0003984_embryonic_growth_retardation	1.09263578
47	MP0002088_abnormal_embryonic_growth/wei	1.06984674
48	MP0005410_abnormal_fertilization	1.06942259
49	MP0005083_abnormal_biliary_tract	1.05796617
50	MP0003890_abnormal_embryonic-extraembry	1.02837219
51	MP0002102_abnormal_ear_morphology	1.01023658
52	MP0001730_embryonic_growth_arrest	1.00542677
53	MP0005253_abnormal_eye_physiology	0.99249300
54	MP0003763_abnormal_thymus_physiology	0.96991903
55	MP0002080_prenatal_lethality	0.96742652
56	MP0005645_abnormal_hypothalamus_physiol	0.96471741
57	MP0001119_abnormal_female_reproductive	0.94204467
58	MP0005395_other_phenotype	0.92500062
59	MP0002084_abnormal_developmental_patter	0.91846258
60	MP0000631_abnormal_neuroendocrine_gland	0.91052959
61	MP0001661_extended_life_span	0.89671663
62	MP0002160_abnormal_reproductive_system	0.88450902
63	MP0003656_abnormal_erythrocyte_physiolo	0.87917525
64	MP0002085_abnormal_embryonic_tissue	0.87834485
65	MP0006072_abnormal_retinal_apoptosis	0.86347694
66	MP0002234_abnormal_pharynx_morphology	0.86239891
67	MP0000703_abnormal_thymus_morphology	0.85070379
68	MP0005551_abnormal_eye_electrophysiolog	0.84998561
69	MP0008872_abnormal_physiological_respon	0.84985916
70	MP0000371_diluted_coat_color	0.84899589
71	MP0005171_absent_coat_pigmentation	0.84136957
72	MP0001529_abnormal_vocalization	0.83473192
73	MP0001293_anophthalmia	0.79442192
74	MP0006035_abnormal_mitochondrial_morpho	0.79222760
75	MP0002086_abnormal_extraembryonic_tissu	0.79148396
76	MP0003699_abnormal_female_reproductive	0.78962385
77	MP0003136_yellow_coat_color	0.76731403
78	MP0009046_muscle_twitch	0.76205795
79	MP0005266_abnormal_metabolism	0.74328456
80	MP0002161_abnormal_fertility/fecundity	0.74306664
81	MP0000358_abnormal_cell_content/	0.72999040
82	MP0005075_abnormal_melanosome_morpholog	0.72378905
83	MP0008770_decreased_survivor_rate	0.72262271
84	MP0009703_decreased_birth_body	0.71945591
85	MP0003646_muscle_fatigue	0.71652381
86	MP0000428_abnormal_craniofacial_morphol	0.71532013
87	MP0005397_hematopoietic_system_phenotyp	0.71388267
88	MP0001545_abnormal_hematopoietic_system	0.71388267
89	MP0005389_reproductive_system_phenotype	0.71307802
90	MP0002398_abnormal_bone_marrow	0.71170702
91	MP0002928_abnormal_bile_duct	0.71115404
92	MP0001764_abnormal_homeostasis	0.70363056
93	MP0002166_altered_tumor_susceptibility	0.68298908
94	MP0002970_abnormal_white_adipose	0.66329534
95	MP0000689_abnormal_spleen_morphology	0.66041227
96	MP0003567_abnormal_fetal_cardiomyocyte	0.65746912
97	MP0005647_abnormal_sex_gland	0.65341374
98	MP0005391_vision/eye_phenotype	0.65119745
99	MP0002006_tumorigenesis	0.63967783
100	MP0002075_abnormal_coat/hair_pigmentati	0.61304422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	6.72760383
2	Chromsome breakage (HP:0040012)	6.49203279
3	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.41075571
4	Abnormality of chromosome stability (HP:0003220)	4.40293765
5	Meckel diverticulum (HP:0002245)	4.02020660
6	Abnormality of the ileum (HP:0001549)	4.00597541
7	Volvulus (HP:0002580)	3.78279540
8	Ectopic kidney (HP:0000086)	3.77327794
9	Abnormality of the preputium (HP:0100587)	3.76801441
10	Clubbing of toes (HP:0100760)	3.63955307
11	Sloping forehead (HP:0000340)	3.46218609
12	Small intestinal stenosis (HP:0012848)	3.45719384
13	Duodenal stenosis (HP:0100867)	3.45719384
14	Birth length less than 3rd percentile (HP:0003561)	3.32814421
15	Duplicated collecting system (HP:0000081)	3.32338988
16	Abnormality of the carotid arteries (HP:0005344)	3.11539937
17	Myelodysplasia (HP:0002863)	3.03362404
18	Abnormality of the duodenum (HP:0002246)	2.99569681
19	Abnormality of DNA repair (HP:0003254)	2.99458603
20	Abnormality of the renal collecting system (HP:0004742)	2.95156514
21	Pancreatic cysts (HP:0001737)	2.83987306
22	Prominent nose (HP:0000448)	2.66615709
23	Absent radius (HP:0003974)	2.61794384
24	Patellar aplasia (HP:0006443)	2.60423610
25	Small hand (HP:0200055)	2.52609016
26	Nephroblastoma (Wilms tumor) (HP:0002667)	2.49884324
27	Aplasia involving forearm bones (HP:0009822)	2.43123402
28	Absent forearm bone (HP:0003953)	2.43123402
29	Pancreatic fibrosis (HP:0100732)	2.42039424
30	Aplasia/Hypoplasia of the patella (HP:0006498)	2.37899970
31	Embryonal renal neoplasm (HP:0011794)	2.35592106
32	Absent thumb (HP:0009777)	2.32932931
33	Acute lymphatic leukemia (HP:0006721)	2.32138068
34	Cerebellar dysplasia (HP:0007033)	2.31821707
35	Short thumb (HP:0009778)	2.31517440
36	Sandal gap (HP:0001852)	2.28064163
37	Squamous cell carcinoma (HP:0002860)	2.25583241
38	Cafe-au-lait spot (HP:0000957)	2.23358872
39	Gaze-evoked nystagmus (HP:0000640)	2.22835828
40	Triphalangeal thumb (HP:0001199)	2.22053018
41	Protruding tongue (HP:0010808)	2.20478060
42	True hermaphroditism (HP:0010459)	2.17057321
43	Molar tooth sign on MRI (HP:0002419)	2.13175359
44	Abnormality of midbrain morphology (HP:0002418)	2.13175359
45	Nephronophthisis (HP:0000090)	2.08695682
46	Long clavicles (HP:0000890)	2.06412663
47	Poikiloderma (HP:0001029)	2.06175560
48	Fair hair (HP:0002286)	2.04795781
49	Attenuation of retinal blood vessels (HP:0007843)	2.04569499
50	Genetic anticipation (HP:0003743)	2.02146147
51	Increased nuchal translucency (HP:0010880)	2.01815139
52	Astigmatism (HP:0000483)	2.01688078
53	Abnormal lung lobation (HP:0002101)	2.00279834
54	Arteriovenous malformation (HP:0100026)	1.99625307
55	Glioma (HP:0009733)	1.98996698
56	Abnormality of chromosome segregation (HP:0002916)	1.98383489
57	Abnormality of the renal medulla (HP:0100957)	1.97384417
58	Bone marrow hypocellularity (HP:0005528)	1.94888854
59	Acute myeloid leukemia (HP:0004808)	1.94741740
60	Abnormality of the renal cortex (HP:0011035)	1.92920967
61	Hypoplasia of the pons (HP:0012110)	1.92549971
62	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.89797022
63	Abnormality of the pons (HP:0007361)	1.87852843
64	Facial hemangioma (HP:0000329)	1.87118218
65	High pitched voice (HP:0001620)	1.84554078
66	Highly arched eyebrow (HP:0002553)	1.83736009
67	Impulsivity (HP:0100710)	1.83073596
68	Chronic hepatic failure (HP:0100626)	1.82861233
69	Microtia (HP:0008551)	1.82395949
70	Intestinal atresia (HP:0011100)	1.81924792
71	Oligohydramnios (HP:0001562)	1.81015397
72	Hypoplastic iliac wings (HP:0002866)	1.80965476
73	Preaxial hand polydactyly (HP:0001177)	1.78408363
74	Poikilocytosis (HP:0004447)	1.77967755
75	Central scotoma (HP:0000603)	1.76104334
76	Abnormality of cochlea (HP:0000375)	1.75028512
77	Dyschromatopsia (HP:0007641)	1.74989745
78	Panhypogammaglobulinemia (HP:0003139)	1.72550907
79	Astrocytoma (HP:0009592)	1.72424168
80	Abnormality of the astrocytes (HP:0100707)	1.72424168
81	Tented upper lip vermilion (HP:0010804)	1.70722457
82	Breast hypoplasia (HP:0003187)	1.70624608
83	Cystic liver disease (HP:0006706)	1.69973479
84	Rhabdomyosarcoma (HP:0002859)	1.68951241
85	Clumsiness (HP:0002312)	1.68851048
86	Acanthocytosis (HP:0001927)	1.67751656
87	Horseshoe kidney (HP:0000085)	1.67691148
88	Congenital stationary night blindness (HP:0007642)	1.65716559
89	Abnormality of pyrimidine metabolism (HP:0004353)	1.65601276
90	Dandy-Walker malformation (HP:0001305)	1.65430811
91	Urethral obstruction (HP:0000796)	1.64849408
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.62285587
93	High anterior hairline (HP:0009890)	1.61945031
94	Partial agenesis of the corpus callosum (HP:0001338)	1.61780242
95	Postaxial foot polydactyly (HP:0001830)	1.59961872
96	Hyperventilation (HP:0002883)	1.59530677
97	Generalized hypopigmentation of hair (HP:0011358)	1.58931205
98	Choanal atresia (HP:0000453)	1.58843536
99	Medulloblastoma (HP:0002885)	1.58823582
100	Truncal obesity (HP:0001956)	1.58268553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.73426186
2	ZAK	3.81633643
3	CDC7	3.61630552
4	BUB1	3.37810110
5	PLK4	3.02658725
6	WEE1	2.93687711
7	BRSK2	2.92091457
8	NEK2	2.71906284
9	BMPR1B	2.60349695
10	CDK12	2.57559185
11	TTK	2.52704056
12	NEK1	2.23038607
13	MKNK2	2.14775879
14	TLK1	2.00888482
15	NUAK1	1.89137728
16	CHEK2	1.86813900
17	SRPK1	1.83320137
18	PBK	1.82916363
19	BRD4	1.80910073
20	ATR	1.73160791
21	ACVR1B	1.69900355
22	PLK1	1.67505884
23	MKNK1	1.65395702
24	CCNB1	1.57968907
25	LATS1	1.54364605
26	PLK3	1.46394048
27	VRK1	1.39690044
28	MAP4K2	1.34356572
29	AURKB	1.28805495
30	STK3	1.27226907
31	CDK8	1.24025370
32	EIF2AK1	1.20843349
33	ATM	1.16618436
34	CDK4	1.15211417
35	CHEK1	1.13251010
36	EIF2AK3	1.09974361
37	BRSK1	1.09318775
38	MST4	1.08119648
39	MARK3	1.05796413
40	CAMK1G	1.04785937
41	INSRR	1.02227280
42	TNIK	1.01996364
43	MELK	1.00339419
44	TAOK3	0.97178420
45	ADRBK2	0.91689886
46	STK4	0.91426822
47	CDK7	0.85550612
48	CAMK1D	0.83581253
49	CLK1	0.81157094
50	CDK1	0.79017886
51	AKT3	0.75065006
52	CDK3	0.73473225
53	PNCK	0.72608251
54	TEC	0.72105889
55	MAPK11	0.71100398
56	EIF2AK2	0.70191452
57	GRK1	0.65233069
58	CDK2	0.65116917
59	RPS6KB2	0.64577091
60	AURKA	0.64000761
61	MAP3K8	0.63269448
62	MAP3K10	0.63169676
63	STK16	0.62810776
64	TAF1	0.62744607
65	SIK2	0.62309313
66	RPS6KA5	0.60591412
67	RPS6KA4	0.57627266
68	WNK4	0.57287491
69	STK38L	0.54442596
70	MAPK13	0.52317911
71	TGFBR1	0.51484199
72	DYRK3	0.50473336
73	FLT3	0.49388934
74	PDK2	0.48696329
75	FGFR2	0.47141482
76	PLK2	0.45005387
77	MAP3K4	0.44931139
78	TRPM7	0.44312762
79	CDK6	0.41495121
80	STK39	0.40981119
81	STK10	0.40141531
82	GSK3B	0.37575053
83	CSNK1A1L	0.37295651
84	MAPK14	0.35738794
85	MAP3K7	0.35484889
86	MTOR	0.35096341
87	NLK	0.34920750
88	MST1R	0.34547247
89	PRKDC	0.34425452
90	WNK1	0.33257735
91	CSNK1D	0.31633184
92	AKT1	0.31467691
93	PIM1	0.29430584
94	CSNK1G1	0.27272321
95	TRIM28	0.25881888
96	PRKAA1	0.25822016
97	ERBB3	0.25356420
98	MAPK1	0.23781266
99	MET	0.23609543
100	WNK3	0.23273159

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.72312573
2	Fanconi anemia pathway_Homo sapiens_hsa03460	4.53374601
3	DNA replication_Homo sapiens_hsa03030	4.50357031
4	Non-homologous end-joining_Homo sapiens_hsa03450	4.05374252
5	Mismatch repair_Homo sapiens_hsa03430	3.64054867
6	Cell cycle_Homo sapiens_hsa04110	3.18068697
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.03811274
8	One carbon pool by folate_Homo sapiens_hsa00670	2.70093167
9	Base excision repair_Homo sapiens_hsa03410	2.63921416
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.46121858
11	RNA transport_Homo sapiens_hsa03013	2.36873004
12	Basal transcription factors_Homo sapiens_hsa03022	2.34788907
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.14370423
14	RNA polymerase_Homo sapiens_hsa03020	2.09265456
15	Selenocompound metabolism_Homo sapiens_hsa00450	2.08293881
16	Spliceosome_Homo sapiens_hsa03040	2.01372946
17	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.01149099
18	Lysine degradation_Homo sapiens_hsa00310	1.81428337
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.76700163
20	RNA degradation_Homo sapiens_hsa03018	1.75179912
21	mRNA surveillance pathway_Homo sapiens_hsa03015	1.69586630
22	p53 signaling pathway_Homo sapiens_hsa04115	1.50766252
23	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.48149504
24	Alcoholism_Homo sapiens_hsa05034	1.43191137
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.32223888
26	Oocyte meiosis_Homo sapiens_hsa04114	1.29970070
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20193528
28	Purine metabolism_Homo sapiens_hsa00230	1.19326415
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.13293375
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.12191770
31	Phototransduction_Homo sapiens_hsa04744	1.10278254
32	Viral carcinogenesis_Homo sapiens_hsa05203	1.05386527
33	Butanoate metabolism_Homo sapiens_hsa00650	1.03474602
34	Olfactory transduction_Homo sapiens_hsa04740	1.00485809
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99233859
36	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.97042869
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94863406
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91061291
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85655429
40	MicroRNAs in cancer_Homo sapiens_hsa05206	0.85177867
41	ABC transporters_Homo sapiens_hsa02010	0.77052715
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72040358
43	Taste transduction_Homo sapiens_hsa04742	0.69889377
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68109628
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65871581
46	Herpes simplex infection_Homo sapiens_hsa05168	0.62645630
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60756495
48	Propanoate metabolism_Homo sapiens_hsa00640	0.51120348
49	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.48919955
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.48500517
51	Small cell lung cancer_Homo sapiens_hsa05222	0.48301663
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45948899
53	Prostate cancer_Homo sapiens_hsa05215	0.45153544
54	HTLV-I infection_Homo sapiens_hsa05166	0.44557075
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44366134
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43668436
57	Proteasome_Homo sapiens_hsa03050	0.43540691
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43310957
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41183743
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38331074
61	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.35239069
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.34687876
63	Melanoma_Homo sapiens_hsa05218	0.33481884
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.31864949
65	FoxO signaling pathway_Homo sapiens_hsa04068	0.31705799
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31483147
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.30012372
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28419819
69	Hepatitis B_Homo sapiens_hsa05161	0.26926638
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25453203
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.25261451
72	Asthma_Homo sapiens_hsa05310	0.25101643
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24150754
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24031981
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.24026801
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23829032
77	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.23641106
78	Platelet activation_Homo sapiens_hsa04611	0.23207065
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22770297
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.22628091
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22328007
82	Non-small cell lung cancer_Homo sapiens_hsa05223	0.22186583
83	Pancreatic cancer_Homo sapiens_hsa05212	0.21765777
84	mTOR signaling pathway_Homo sapiens_hsa04150	0.21397409
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19370052
86	Metabolic pathways_Homo sapiens_hsa01100	0.18990897
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.18076594
88	Nicotine addiction_Homo sapiens_hsa05033	0.17168184
89	Measles_Homo sapiens_hsa05162	0.16763022
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.16599895
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.16420374
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.15989628
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.15080200
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.11775156
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.11469441
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.11215336
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.11178503
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.10775917
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.10595451
100	Colorectal cancer_Homo sapiens_hsa05210	0.10372898

ARHGAP11B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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