ARHGAP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)5.23734362
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.40656049
3glutamate receptor signaling pathway (GO:0007215)4.28165725
4relaxation of cardiac muscle (GO:0055119)4.24301844
5negative regulation of sodium ion transport (GO:0010766)4.23899291
6rRNA modification (GO:0000154)4.05671526
7axonal fasciculation (GO:0007413)3.75008964
8vocalization behavior (GO:0071625)3.74669270
9neuron cell-cell adhesion (GO:0007158)3.74138199
10presynaptic membrane assembly (GO:0097105)3.73204377
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66389808
12positive regulation of muscle hypertrophy (GO:0014742)3.64063126
13positive regulation of cardiac muscle hypertrophy (GO:0010613)3.64063126
14neuron recognition (GO:0008038)3.58005559
15negative regulation of hormone biosynthetic process (GO:0032353)3.55728123
16negative regulation of hormone metabolic process (GO:0032351)3.55728123
17gamma-aminobutyric acid signaling pathway (GO:0007214)3.55194495
18synaptic vesicle endocytosis (GO:0048488)3.52757008
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48666040
20embryonic retina morphogenesis in camera-type eye (GO:0060059)3.36416081
21inner ear receptor cell development (GO:0060119)3.34842477
22synaptic transmission, glutamatergic (GO:0035249)3.32878609
23innervation (GO:0060384)3.32798227
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31910092
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31329369
26startle response (GO:0001964)3.29821061
27regulation of glutamate receptor signaling pathway (GO:1900449)3.29422424
28presynaptic membrane organization (GO:0097090)3.27012762
29postsynaptic membrane organization (GO:0001941)3.26408554
30lens fiber cell differentiation (GO:0070306)3.24466035
31dendritic spine morphogenesis (GO:0060997)3.24440439
32neuron-neuron synaptic transmission (GO:0007270)3.21261600
33righting reflex (GO:0060013)3.12639283
34paraxial mesoderm development (GO:0048339)3.07526462
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07340907
36cochlea development (GO:0090102)3.05726262
37histone H3-K36 demethylation (GO:0070544)3.04941732
38regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.98787754
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.96443949
40dorsal/ventral axis specification (GO:0009950)2.94166192
41serotonin receptor signaling pathway (GO:0007210)2.93115581
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89398383
43behavioral defense response (GO:0002209)2.88916312
44behavioral fear response (GO:0001662)2.88916312
45long-term synaptic potentiation (GO:0060291)2.88532651
46microglial cell activation (GO:0001774)2.87753425
47fear response (GO:0042596)2.84618231
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84326045
49proline transport (GO:0015824)2.81807388
50response to histamine (GO:0034776)2.81034379
51dendritic spine organization (GO:0097061)2.76529480
52apical protein localization (GO:0045176)2.76409270
53mitotic sister chromatid cohesion (GO:0007064)2.74673538
54relaxation of muscle (GO:0090075)2.73972853
55asymmetric protein localization (GO:0008105)2.73971316
56neurotransmitter-gated ion channel clustering (GO:0072578)2.72380533
57regulation of cell communication by electrical coupling (GO:0010649)2.72075541
58positive regulation of cardiac muscle cell differentiation (GO:2000727)2.71443971
59embryonic foregut morphogenesis (GO:0048617)2.69845668
60glycerophospholipid catabolic process (GO:0046475)2.66404950
61central nervous system projection neuron axonogenesis (GO:0021952)2.66172669
62regulation of Rac protein signal transduction (GO:0035020)2.64236189
63dentate gyrus development (GO:0021542)2.62790509
64regulation of synaptic transmission, glutamatergic (GO:0051966)2.62589236
65nuclear pore complex assembly (GO:0051292)2.61654034
66regulation of centriole replication (GO:0046599)2.58795610
67C4-dicarboxylate transport (GO:0015740)2.58308103
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57867795
69eosinophil chemotaxis (GO:0048245)2.57475769
70regulation of bile acid biosynthetic process (GO:0070857)2.57184188
71regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54893439
72limb bud formation (GO:0060174)2.53938755
73negative regulation of keratinocyte proliferation (GO:0010839)2.53519057
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.53257022
75negative regulation of dendrite development (GO:2000171)2.51577600
76vesicle transport along microtubule (GO:0047496)2.51545640
77regulation of Rac GTPase activity (GO:0032314)2.51378617
78genitalia morphogenesis (GO:0035112)2.51376472
79establishment of nucleus localization (GO:0040023)2.51356529
80regulation of postsynaptic membrane potential (GO:0060078)2.49883435
81gastrulation with mouth forming second (GO:0001702)2.49878216
82cerebellar Purkinje cell differentiation (GO:0021702)2.49733372
83regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47851632
84striatum development (GO:0021756)2.47831499
85nuclear pore organization (GO:0006999)2.47019854
86social behavior (GO:0035176)2.46411886
87intraspecies interaction between organisms (GO:0051703)2.46411886
88dendrite development (GO:0016358)2.45720213
89protein localization to synapse (GO:0035418)2.45606507
90regulation of cardiac muscle hypertrophy (GO:0010611)2.45012008
91calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44543100
92cartilage morphogenesis (GO:0060536)2.44360638
93female mating behavior (GO:0060180)2.44141884
94regulation of dendritic spine morphogenesis (GO:0061001)2.43315438
95regulation of muscle adaptation (GO:0043502)2.43283473
96anterior/posterior axis specification, embryo (GO:0008595)2.43143242
97positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.41588057
98synapse assembly (GO:0007416)2.41147974
99exploration behavior (GO:0035640)2.40274428
100transmission of nerve impulse (GO:0019226)2.40095594
101glycosphingolipid biosynthetic process (GO:0006688)2.39994636
102negative regulation of systemic arterial blood pressure (GO:0003085)2.39332611
103multicellular organismal reproductive behavior (GO:0033057)2.39225600
104regulation of centrosome duplication (GO:0010824)2.36805533
105multicellular organismal signaling (GO:0035637)2.35638948
106negative regulation of histone acetylation (GO:0035067)2.35553799
107regulation of inositol phosphate biosynthetic process (GO:0010919)2.35184099
108histone H3-K9 demethylation (GO:0033169)2.35084076
109prostate gland growth (GO:0060736)2.34631173
110regulation of transforming growth factor beta2 production (GO:0032909)2.34239013
111regulation of muscle hypertrophy (GO:0014743)2.34203571
112central nervous system neuron axonogenesis (GO:0021955)2.33550910
113eye photoreceptor cell differentiation (GO:0001754)2.33062543
114photoreceptor cell differentiation (GO:0046530)2.33062543
115serotonin metabolic process (GO:0042428)2.32126999
116regulation of female receptivity (GO:0045924)2.31922176
117nucleus localization (GO:0051647)2.31600549
118positive regulation of response to oxidative stress (GO:1902884)2.30055141
119positive regulation of cellular response to oxidative stress (GO:1900409)2.30055141
120base-excision repair, AP site formation (GO:0006285)2.29191163
121positive regulation of vesicle fusion (GO:0031340)2.29132655
122vascular smooth muscle contraction (GO:0014829)2.26030217
123intraciliary transport (GO:0042073)2.25710188
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24894404
125hippo signaling (GO:0035329)2.20139396
126positive regulation of glycoprotein biosynthetic process (GO:0010560)2.16989015
127establishment of protein localization to Golgi (GO:0072600)2.15438905
128protein targeting to Golgi (GO:0000042)2.15172766
129retina vasculature morphogenesis in camera-type eye (GO:0061299)2.14245755
130positive regulation of male gonad development (GO:2000020)2.10472616
131regulation of sulfur metabolic process (GO:0042762)2.09412206
132COPII vesicle coating (GO:0048208)2.09382547
133neural tube formation (GO:0001841)2.08686324
134negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.07669839
135ephrin receptor signaling pathway (GO:0048013)2.07402041
136notochord development (GO:0030903)2.07014556
137regulation of keratinocyte proliferation (GO:0010837)2.06172743
138olfactory bulb development (GO:0021772)2.05940365
139short-term memory (GO:0007614)2.05794523
140mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.03423324
141ectodermal placode formation (GO:0060788)2.00535346
142gap junction assembly (GO:0016264)2.00341036
143retina layer formation (GO:0010842)1.99600909
144phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.99247571
145membrane budding (GO:0006900)1.97934587
146cerebral cortex cell migration (GO:0021795)1.97085097
147regulation of centrosome cycle (GO:0046605)1.96539868
148positive regulation of glycoprotein metabolic process (GO:1903020)1.96078618
149glial cell proliferation (GO:0014009)1.95944004
150regulation of nephron tubule epithelial cell differentiation (GO:0072182)1.95855924
151NLS-bearing protein import into nucleus (GO:0006607)1.94703347
152regulation of acyl-CoA biosynthetic process (GO:0050812)1.94199392
153cytoplasmic mRNA processing body assembly (GO:0033962)1.93941068
154labyrinthine layer development (GO:0060711)1.93502397
155Leydig cell differentiation (GO:0033327)1.93345726
156membrane assembly (GO:0071709)1.92897567
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.91060051
158nonmotile primary cilium assembly (GO:0035058)1.90719838
159retrograde transport, vesicle recycling within Golgi (GO:0000301)1.90602750
160desmosome organization (GO:0002934)1.90506325
161endoplasmic reticulum organization (GO:0007029)1.89963747
162myelin assembly (GO:0032288)1.88064501
163fibroblast migration (GO:0010761)1.87297316
164organelle transport along microtubule (GO:0072384)1.87101052
165regulation of coenzyme metabolic process (GO:0051196)1.87004869
166regulation of cofactor metabolic process (GO:0051193)1.87004869
167regulation of growth hormone secretion (GO:0060123)1.85793947
168G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.84674248
169cellular sodium ion homeostasis (GO:0006883)1.84215707
170regulation of cAMP-dependent protein kinase activity (GO:2000479)1.83562761
171dendrite morphogenesis (GO:0048813)1.82816645
172protein heterotetramerization (GO:0051290)1.81728537
173anterior/posterior axis specification (GO:0009948)1.81659750
174Golgi to plasma membrane protein transport (GO:0043001)1.81076414
175negative regulation of DNA recombination (GO:0045910)1.81005325
176peptidyl-lysine dimethylation (GO:0018027)1.80702151
177Golgi to endosome transport (GO:0006895)1.79970311
178regulation of axon extension involved in axon guidance (GO:0048841)1.79884412
179cellular response to sterol (GO:0036315)1.79759449
180UDP-N-acetylglucosamine metabolic process (GO:0006047)1.79440322
181retinal ganglion cell axon guidance (GO:0031290)1.78563682
182bundle of His cell to Purkinje myocyte communication (GO:0086069)1.78355075
183regulation of myelination (GO:0031641)1.78131349
184negative regulation of JUN kinase activity (GO:0043508)1.77835893
185regulation of protein glycosylation (GO:0060049)1.77601760
186cell adhesion mediated by integrin (GO:0033627)1.76857568
187regulation of axon guidance (GO:1902667)1.76763990
188protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)1.76553657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74920907
2GBX2_23144817_ChIP-Seq_PC3_Human3.70294929
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76551752
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37308711
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34298203
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.32915654
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.24376851
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23831179
9TAF15_26573619_Chip-Seq_HEK293_Human2.18734733
10SMAD4_21799915_ChIP-Seq_A2780_Human2.17160030
11PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07973787
12* P300_19829295_ChIP-Seq_ESCs_Human2.04073357
13FUS_26573619_Chip-Seq_HEK293_Human2.00836547
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.97167596
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96143834
16TP53_16413492_ChIP-PET_HCT116_Human1.92678916
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.92150483
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87619144
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86887964
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83517879
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82127670
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81979954
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81622433
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80794532
25IGF1R_20145208_ChIP-Seq_DFB_Human1.79301095
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.79062836
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78947939
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78441654
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.77528246
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76033476
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.73408955
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73183165
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.72769034
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72651780
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.69552524
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67289687
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64918751
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63768906
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63510895
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63510895
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62386623
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.61545075
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59335538
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56439145
45STAT3_23295773_ChIP-Seq_U87_Human1.56383626
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56328919
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.56266556
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55196342
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52887460
50AR_25329375_ChIP-Seq_VCAP_Human1.52697498
51EWS_26573619_Chip-Seq_HEK293_Human1.50750604
52AR_21572438_ChIP-Seq_LNCaP_Human1.50744377
53BCAT_22108803_ChIP-Seq_LS180_Human1.50084609
54ZNF274_21170338_ChIP-Seq_K562_Hela1.49584191
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.49504344
56RNF2_27304074_Chip-Seq_NSC_Mouse1.48658080
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47793330
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.46327030
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.46258597
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46096929
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43928612
62P53_22387025_ChIP-Seq_ESCs_Mouse1.43338946
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43336722
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43336722
65VDR_22108803_ChIP-Seq_LS180_Human1.42092981
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40608308
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.40221730
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39865719
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39659488
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.39434754
71* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38948787
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38663851
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36275937
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36245078
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.34961491
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34735031
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34425340
78REST_21632747_ChIP-Seq_MESCs_Mouse1.33839152
79* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33669786
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33505331
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33406047
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32867271
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30593192
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30581904
85P300_18555785_Chip-Seq_ESCs_Mouse1.30423676
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30373963
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.30151150
88TCF4_23295773_ChIP-Seq_U87_Human1.29441698
89* CJUN_26792858_Chip-Seq_BT549_Human1.29271653
90AR_21909140_ChIP-Seq_LNCAP_Human1.28767563
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.28442755
92RUNX2_22187159_ChIP-Seq_PCA_Human1.27839071
93AHR_22903824_ChIP-Seq_MCF-7_Human1.27746468
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27564451
95* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27002722
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.26633971
97TP53_18474530_ChIP-ChIP_U2OS_Human1.25283715
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25155028
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.24013867
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.23924532
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23833669
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23704046
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21583538
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.21156235
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20283650
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20200578
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.17872825
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17386734
109TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17313985
110TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17133463
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16377102
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16377102
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16134534
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15861982
115TCF4_22108803_ChIP-Seq_LS180_Human1.15620035
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15210775
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14786162
118ER_23166858_ChIP-Seq_MCF-7_Human1.14745010
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.14425177
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.14114747
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12347977
122* BRD4_25478319_ChIP-Seq_HGPS_Human1.12276977
123* CDX2_22108803_ChIP-Seq_LS180_Human1.11705631
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11377869
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11239560
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10465544
127* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10389643
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10039256
129CBP_20019798_ChIP-Seq_JUKART_Human1.10039256
130* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09981216
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09793406
132RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08517221
133SOX9_26525672_Chip-Seq_HEART_Mouse1.07754295
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07454311
135* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07148842
136TAL1_26923725_Chip-Seq_HPCs_Mouse1.06904589
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03803289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.32312752
2MP0004859_abnormal_synaptic_plasticity3.84244478
3MP0003787_abnormal_imprinting3.13133669
4MP0010234_abnormal_vibrissa_follicle3.03432734
5MP0003635_abnormal_synaptic_transmissio2.82191371
6MP0006292_abnormal_olfactory_placode2.76909358
7MP0002063_abnormal_learning/memory/cond2.65733887
8MP0001188_hyperpigmentation2.61416008
9MP0002736_abnormal_nociception_after2.47053455
10MP0009745_abnormal_behavioral_response2.41457512
11MP0001968_abnormal_touch/_nociception2.40922967
12MP0002572_abnormal_emotion/affect_behav2.40091001
13MP0000778_abnormal_nervous_system2.37535335
14MP0002254_reproductive_system_inflammat2.34426846
15MP0004270_analgesia2.29526978
16MP0001501_abnormal_sleep_pattern2.25341820
17MP0002102_abnormal_ear_morphology2.14319437
18MP0003136_yellow_coat_color2.12448340
19MP0005646_abnormal_pituitary_gland2.12177309
20MP0001486_abnormal_startle_reflex2.05147388
21MP0000566_synostosis2.01522366
22MP0006276_abnormal_autonomic_nervous1.93712400
23MP0002064_seizures1.93516631
24MP0000569_abnormal_digit_pigmentation1.86099740
25MP0001440_abnormal_grooming_behavior1.84694939
26MP0001299_abnormal_eye_distance/1.84604397
27MP0010352_gastrointestinal_tract_polyps1.80197641
28MP0001984_abnormal_olfaction1.75213552
29MP0002638_abnormal_pupillary_reflex1.70786311
30MP0002067_abnormal_sensory_capabilities1.69817410
31MP0004272_abnormal_basement_membrane1.68407736
32MP0009780_abnormal_chondrocyte_physiolo1.64653953
33MP0002734_abnormal_mechanical_nocicepti1.61257169
34MP0002233_abnormal_nose_morphology1.58833259
35MP0010386_abnormal_urinary_bladder1.58532963
36MP0000538_abnormal_urinary_bladder1.57118737
37MP0009697_abnormal_copulation1.55687490
38MP0000647_abnormal_sebaceous_gland1.53218687
39MP0002557_abnormal_social/conspecific_i1.51813195
40MP0002876_abnormal_thyroid_physiology1.50711985
41MP0001502_abnormal_circadian_rhythm1.49468634
42MP0010678_abnormal_skin_adnexa1.47831663
43MP0005171_absent_coat_pigmentation1.46826485
44MP0001293_anophthalmia1.45852872
45MP0003868_abnormal_feces_composition1.44212285
46MP0003941_abnormal_skin_development1.43534876
47MP0001529_abnormal_vocalization1.43382424
48MP0005386_behavior/neurological_phenoty1.43100997
49MP0004924_abnormal_behavior1.43100997
50MP0002272_abnormal_nervous_system1.42450892
51MP0002184_abnormal_innervation1.42063054
52MP0004484_altered_response_of1.41576682
53MP0003121_genomic_imprinting1.41128122
54MP0002697_abnormal_eye_size1.35030364
55MP0002277_abnormal_respiratory_mucosa1.32030940
56MP0005379_endocrine/exocrine_gland_phen1.30685416
57MP0003950_abnormal_plasma_membrane1.30038226
58MP0003890_abnormal_embryonic-extraembry1.29838663
59MP0003567_abnormal_fetal_cardiomyocyte1.28313787
60MP0002735_abnormal_chemical_nociception1.28154468
61MP0009046_muscle_twitch1.20681831
62MP0008057_abnormal_DNA_replication1.20375849
63MP0004885_abnormal_endolymph1.19068472
64MP0001286_abnormal_eye_development1.18542365
65MP0002877_abnormal_melanocyte_morpholog1.17947483
66MP0005367_renal/urinary_system_phenotyp1.16873235
67MP0000516_abnormal_urinary_system1.16873235
68MP0002084_abnormal_developmental_patter1.15406005
69MP0006072_abnormal_retinal_apoptosis1.14418421
70MP0002909_abnormal_adrenal_gland1.13398775
71MP0004883_abnormal_blood_vessel1.12711367
72MP0000631_abnormal_neuroendocrine_gland1.12083873
73MP0003755_abnormal_palate_morphology1.11994278
74MP0008877_abnormal_DNA_methylation1.11465419
75MP0008007_abnormal_cellular_replicative1.10879898
76MP0000383_abnormal_hair_follicle1.08719384
77MP0001177_atelectasis1.08618851
78MP0005623_abnormal_meninges_morphology1.08406221
79MP0006054_spinal_hemorrhage1.06282902
80MP0002163_abnormal_gland_morphology1.05757729
81MP0001666_abnormal_nutrient_absorption1.04790293
82MP0009703_decreased_birth_body1.04660897
83MP0002733_abnormal_thermal_nociception1.04457159
84MP0004215_abnormal_myocardial_fiber1.04099626
85MP0000428_abnormal_craniofacial_morphol1.01451877
86MP0003119_abnormal_digestive_system1.01306905
87MP0002092_abnormal_eye_morphology0.99608352
88MP0002882_abnormal_neuron_morphology0.97329208
89MP0001963_abnormal_hearing_physiology0.97237697
90MP0002249_abnormal_larynx_morphology0.96885983
91MP0005085_abnormal_gallbladder_physiolo0.95746375
92MP0004197_abnormal_fetal_growth/weight/0.95706602
93MP0005551_abnormal_eye_electrophysiolog0.95684632
94MP0003935_abnormal_craniofacial_develop0.94416115
95MP0005248_abnormal_Harderian_gland0.94007971
96MP0002090_abnormal_vision0.93911813
97MP0000462_abnormal_digestive_system0.93901850
98MP0001919_abnormal_reproductive_system0.92530737
99MP0000026_abnormal_inner_ear0.92234259
100MP0003632_abnormal_nervous_system0.92011848
101MP0001905_abnormal_dopamine_level0.91742180
102MP0002152_abnormal_brain_morphology0.91529882
103MP0000762_abnormal_tongue_morphology0.91407902
104MP0001346_abnormal_lacrimal_gland0.90884802
105MP0000432_abnormal_head_morphology0.90702233
106MP0002837_dystrophic_cardiac_calcinosis0.90291160
107MP0003252_abnormal_bile_duct0.89948213
108MP0005275_abnormal_skin_tensile0.89947022
109MP0010368_abnormal_lymphatic_system0.89267085
110MP0003221_abnormal_cardiomyocyte_apopto0.88595372
111MP0005253_abnormal_eye_physiology0.88551772
112MP0008875_abnormal_xenobiotic_pharmacok0.86884732
113MP0005391_vision/eye_phenotype0.86554774
114MP0005423_abnormal_somatic_nervous0.86043013
115MP0005408_hypopigmentation0.85770529
116MP0001970_abnormal_pain_threshold0.85078343
117MP0005187_abnormal_penis_morphology0.84358173
118MP0005645_abnormal_hypothalamus_physiol0.84267261
119MP0003195_calcinosis0.83481159
120MP0000955_abnormal_spinal_cord0.83283233
121MP0002751_abnormal_autonomic_nervous0.82484872
122MP0000534_abnormal_ureter_morphology0.82292147
123MP0008438_abnormal_cutaneous_collagen0.82046486
124MP0005257_abnormal_intraocular_pressure0.81912739
125MP0003943_abnormal_hepatobiliary_system0.80326891
126MP0000427_abnormal_hair_cycle0.80242509
127MP0009384_cardiac_valve_regurgitation0.80081554
128MP0004858_abnormal_nervous_system0.79676107
129MP0004264_abnormal_extraembryonic_tissu0.79551093
130MP0003937_abnormal_limbs/digits/tail_de0.79507634
131MP0003718_maternal_effect0.79357725
132MP0005310_abnormal_salivary_gland0.79325746
133MP0003115_abnormal_respiratory_system0.78905315
134MP0002822_catalepsy0.78671895
135MP0002234_abnormal_pharynx_morphology0.78054705
136MP0001485_abnormal_pinna_reflex0.77986745
137MP0003631_nervous_system_phenotype0.77750162
138MP0002066_abnormal_motor_capabilities/c0.77672729
139MP0005197_abnormal_uvea_morphology0.77610486
140MP0003385_abnormal_body_wall0.74808078
141MP0002896_abnormal_bone_mineralization0.74145382
142MP0002085_abnormal_embryonic_tissue0.72742160
143MP0002177_abnormal_outer_ear0.72626305
144MP0001324_abnormal_eye_pigmentation0.72467309
145MP0003122_maternal_imprinting0.72342083
146MP0003942_abnormal_urinary_system0.71643411
147MP0003633_abnormal_nervous_system0.71401629
148MP0002009_preneoplasia0.71282736
149MP0005365_abnormal_bile_salt0.70271943
150MP0001340_abnormal_eyelid_morphology0.70149585
151MP0004742_abnormal_vestibular_system0.69321518
152MP0000681_abnormal_thyroid_gland0.68998821
153MP0003861_abnormal_nervous_system0.68624840
154MP0002168_other_aberrant_phenotype0.68559846
155MP0002111_abnormal_tail_morphology0.67783778
156MP0001915_intracranial_hemorrhage0.67782893
157MP0002127_abnormal_cardiovascular_syste0.67688886
158MP0002938_white_spotting0.66301207
159MP0002269_muscular_atrophy0.64920321
160MP0000639_abnormal_adrenal_gland0.63408818

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.95086136
2Febrile seizures (HP:0002373)4.54881785
3Atonic seizures (HP:0010819)3.70894554
4Oligodactyly (hands) (HP:0001180)3.49750472
5Generalized hypopigmentation of hair (HP:0011358)3.40093988
6Abnormality of the labia minora (HP:0012880)3.29163971
7Focal seizures (HP:0007359)3.25546701
8Papillary thyroid carcinoma (HP:0002895)3.15944309
9Epileptic encephalopathy (HP:0200134)3.13171280
10Absent frontal sinuses (HP:0002688)3.11429355
11Protruding tongue (HP:0010808)3.10603196
12Fair hair (HP:0002286)3.07006092
13Excessive salivation (HP:0003781)3.05124763
14Drooling (HP:0002307)3.05124763
15Absent speech (HP:0001344)2.93557422
16Asymmetry of the thorax (HP:0001555)2.87665857
17Thyroid carcinoma (HP:0002890)2.83537448
18Tubulointerstitial nephritis (HP:0001970)2.83361667
19Arterial tortuosity (HP:0005116)2.78436839
20Hyperventilation (HP:0002883)2.77562614
21Hepatoblastoma (HP:0002884)2.69913939
22Generalized tonic-clonic seizures (HP:0002069)2.68743885
23Chronic hepatic failure (HP:0100626)2.66412843
24Absence seizures (HP:0002121)2.63469669
25Aplasia involving bones of the extremities (HP:0009825)2.62687683
26Aplasia involving bones of the upper limbs (HP:0009823)2.62687683
27Aplasia of the phalanges of the hand (HP:0009802)2.62687683
28Progressive cerebellar ataxia (HP:0002073)2.58547851
29Vertebral arch anomaly (HP:0008438)2.43176814
30Broad-based gait (HP:0002136)2.42973097
31Blue irides (HP:0000635)2.41759162
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39840140
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.39840140
34Urethral obstruction (HP:0000796)2.39733843
35Bifid tongue (HP:0010297)2.35099506
36Fibular aplasia (HP:0002990)2.31826325
37Exotropia (HP:0000577)2.31318640
38Inappropriate behavior (HP:0000719)2.26837224
39Spondylolisthesis (HP:0003302)2.26769064
40Aqueductal stenosis (HP:0002410)2.25549511
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24643682
42Abnormality of the corticospinal tract (HP:0002492)2.23524403
43Renal cortical cysts (HP:0000803)2.22305147
44Dialeptic seizures (HP:0011146)2.21439926
45Progressive sensorineural hearing impairment (HP:0000408)2.21290070
46Agnosia (HP:0010524)2.20201074
47Vascular tortuosity (HP:0004948)2.19881720
48Neoplasm of the tracheobronchial system (HP:0100552)2.17797120
49Abnormality of the axillary hair (HP:0100134)2.15861204
50Abnormality of secondary sexual hair (HP:0009888)2.15861204
51Genital tract atresia (HP:0001827)2.15757411
52Abnormality of salivation (HP:0100755)2.15414853
53Glomerulonephritis (HP:0000099)2.14735276
54Chin dimple (HP:0010751)2.13997105
55Retinal atrophy (HP:0001105)2.13977889
56Upper motor neuron abnormality (HP:0002127)2.13019766
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.12838490
58Vaginal atresia (HP:0000148)2.12007600
59Amblyopia (HP:0000646)2.11230149
60Action tremor (HP:0002345)2.10285244
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10156355
62Abnormality of the labia (HP:0000058)2.09985948
63Syringomyelia (HP:0003396)2.08409560
64Spinal cord lesions (HP:0100561)2.08409560
65Prostate neoplasm (HP:0100787)2.06300885
66Insidious onset (HP:0003587)2.04490499
67Termporal pattern (HP:0011008)2.04490499
68Facial hemangioma (HP:0000329)2.03731600
69Heterochromia iridis (HP:0001100)2.02784140
70Scanning speech (HP:0002168)2.02151483
71Intestinal atresia (HP:0011100)2.02053043
72Widely spaced teeth (HP:0000687)2.01346630
73Gait imbalance (HP:0002141)2.01318078
74Abnormality of the antihelix (HP:0009738)2.00761203
75Complete atrioventricular canal defect (HP:0001674)2.00739046
76Abnormality of the frontal sinuses (HP:0002687)2.00245162
77Labial hypoplasia (HP:0000066)1.99435434
78Biliary tract neoplasm (HP:0100574)1.99424100
79Alveolar cell carcinoma (HP:0006519)1.99399954
80Hypoplastic labia majora (HP:0000059)1.98498619
81Congenital primary aphakia (HP:0007707)1.95890048
82Pulmonic stenosis (HP:0001642)1.95386261
83Intellectual disability, progressive (HP:0006887)1.93102062
84Oligodactyly (HP:0012165)1.92159340
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.90375571
86Abnormal biliary tract morphology (HP:0012440)1.89230050
87Volvulus (HP:0002580)1.89067947
88Urinary urgency (HP:0000012)1.87677819
89Transitional cell carcinoma of the bladder (HP:0006740)1.87599184
90True hermaphroditism (HP:0010459)1.84825353
91Hypothermia (HP:0002045)1.84348124
92Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83595637
93Systemic lupus erythematosus (HP:0002725)1.81819703
94Broad alveolar ridges (HP:0000187)1.81312037
95Inability to walk (HP:0002540)1.80312839
96Adrenal hypoplasia (HP:0000835)1.80126104
97Astrocytoma (HP:0009592)1.79845485
98Abnormality of the astrocytes (HP:0100707)1.79845485
99Impaired vibration sensation in the lower limbs (HP:0002166)1.79499090
100Poor coordination (HP:0002370)1.79135337
101Pheochromocytoma (HP:0002666)1.79024388
102Heterotopia (HP:0002282)1.78586101
103Occipital encephalocele (HP:0002085)1.77951791
104Decreased lacrimation (HP:0000633)1.77643899
105Spontaneous abortion (HP:0005268)1.77500329
106Nephrogenic diabetes insipidus (HP:0009806)1.77109052
107Submucous cleft hard palate (HP:0000176)1.76223889
108Abnormality of the labia majora (HP:0012881)1.75406349
109Hyperkalemia (HP:0002153)1.75345338
110Malignant gastrointestinal tract tumors (HP:0006749)1.75334870
111Gastrointestinal carcinoma (HP:0002672)1.75334870
112Intrahepatic cholestasis (HP:0001406)1.75284337
113Deeply set eye (HP:0000490)1.75143544
114Chronic diarrhea (HP:0002028)1.73477807
115Cerebral inclusion bodies (HP:0100314)1.73292138
116Polyphagia (HP:0002591)1.73235776
117Medial flaring of the eyebrow (HP:0010747)1.72201445
118Microglossia (HP:0000171)1.72109773
119Medulloblastoma (HP:0002885)1.71983488
120Fetal akinesia sequence (HP:0001989)1.71460248
121Bladder carcinoma (HP:0002862)1.70960883
122Bladder neoplasm (HP:0009725)1.70960883
123Nephroblastoma (Wilms tumor) (HP:0002667)1.70573950
124Abnormality of the lower motor neuron (HP:0002366)1.70420322
125Absent eyebrow (HP:0002223)1.70245415
126Congenital sensorineural hearing impairment (HP:0008527)1.69827714
127Curly hair (HP:0002212)1.69580334
128Visual hallucinations (HP:0002367)1.69229002
129Abnormality of binocular vision (HP:0011514)1.68913324
130Diplopia (HP:0000651)1.68913324
131Atrioventricular canal defect (HP:0006695)1.68740163
132Cutaneous finger syndactyly (HP:0010554)1.68526649
133Autism (HP:0000717)1.68430151
134Neonatal hypoglycemia (HP:0001998)1.68280802
135Aplasia cutis congenita (HP:0001057)1.67570826
136Hypoplastic nipples (HP:0002557)1.66679750
137Embryonal renal neoplasm (HP:0011794)1.66052564
138Hypoplastic female external genitalia (HP:0012815)1.65932699
139Anterior segment dysgenesis (HP:0007700)1.65891605
140Cortical dysplasia (HP:0002539)1.65402901
141Bifid scrotum (HP:0000048)1.65349775
142Rhabdomyosarcoma (HP:0002859)1.63747657
143Hypoglycemic seizures (HP:0002173)1.63614451
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.62772775
145Shawl scrotum (HP:0000049)1.62253126
146Conjugated hyperbilirubinemia (HP:0002908)1.61991571
147Neoplasm of the small intestine (HP:0100833)1.61150945
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60728652
149Renal hypoplasia (HP:0000089)1.60443570
150Cutaneous syndactyly (HP:0012725)1.60297657
151Tetraparesis (HP:0002273)1.59596064
152Hyperglycinemia (HP:0002154)1.58144728
153Alacrima (HP:0000522)1.56271953
154Supernumerary spleens (HP:0009799)1.55018951
155Short tibia (HP:0005736)1.54366057
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.54045870
157Glioma (HP:0009733)1.53005001
158Anophthalmia (HP:0000528)1.52851327
159Broad foot (HP:0001769)1.52343049
160Cubitus valgus (HP:0002967)1.52282333
161Abnormality of the nasal septum (HP:0000419)1.50297987
162Micropenis (HP:0000054)1.49738579
163Median cleft lip (HP:0000161)1.48868767
164Double outlet right ventricle (HP:0001719)1.47143998
165Congenital malformation of the right heart (HP:0011723)1.47143998
166Proximal tubulopathy (HP:0000114)1.46669582
167Myelomeningocele (HP:0002475)1.45804465
168Midline defect of the nose (HP:0004122)1.44379615
169Postaxial hand polydactyly (HP:0001162)1.43538247
170Chorioretinal atrophy (HP:0000533)1.43477726
171Abnormal sex determination (HP:0012244)1.43339809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD48.15617634
2MAP3K133.65123293
3EPHA43.26935110
4TNIK3.04487597
5NTRK32.95875023
6RIPK42.77589448
7FRK2.70727982
8MAP3K42.63828971
9TRIM282.52951266
10STK392.38403618
11MKNK22.37687624
12BMPR22.36585516
13EIF2AK32.27394863
14MET2.22377193
15CASK2.04030620
16PBK2.03074823
17STK38L2.00029724
18MAP2K71.82638964
19GRK71.78748562
20MAP3K121.76753862
21ACVR1B1.73602575
22LATS11.71604416
23MST1R1.70921460
24BRSK21.68751551
25SGK21.57820498
26CDK91.57438400
27MAPK131.54095542
28MAP2K41.52818950
29MAP3K141.45043111
30NEK91.42351155
31EPHA21.38194850
32NTRK21.32626760
33PLK21.29992975
34TSSK61.29310189
35FGFR11.28339100
36AKT31.28240416
37MAP3K91.24888813
38PDGFRA1.24324863
39CSNK1G21.23317673
40CDK81.20999098
41CSNK1G11.14016931
42KSR11.12209258
43MKNK11.09218457
44CSNK1A1L1.07862779
45ERBB41.06665413
46MINK11.04348013
47LATS21.02268958
48STK381.01763575
49MARK11.00645742
50TAOK30.98152401
51SGK30.97009959
52SGK4940.95782691
53SGK2230.95782691
54NEK10.94182377
55MAP3K60.94140270
56MOS0.92251382
57SRPK10.89925095
58CDK30.89351460
59GRK50.84854037
60CSNK1G30.83685971
61NEK60.83496613
62EPHA30.81612759
63CAMK2A0.79575858
64FGR0.79526247
65BMPR1B0.79349852
66WNK40.78617276
67YES10.77610739
68MAP3K20.77153370
69SCYL20.76966378
70CAMK1G0.76614460
71ERBB30.75753812
72BCR0.74663714
73NUAK10.73770347
74FGFR20.72906848
75SGK10.72505240
76NLK0.70381550
77MELK0.70247116
78SIK30.69562409
79PLK30.69498997
80TIE10.68713679
81TGFBR20.66768934
82FER0.64691001
83DYRK1A0.63912998
84WEE10.62057031
85PINK10.60904127
86PTK20.59874496
87PLK40.58985805
88OXSR10.58975947
89SIK20.58326656
90PRKCE0.58168223
91EPHB20.56494978
92LMTK20.56456610
93EIF2AK20.54825223
94PTK2B0.53931225
95PRKD30.53794777
96MST40.52078793
97PRKCQ0.50893798
98WNK10.50682598
99ROCK20.47479727
100PRKCG0.47383808
101PKN10.47151239
102WNK30.46930761
103ROCK10.45143975
104PAK30.44988602
105CSNK1D0.44981884
106PDK20.44836813
107PRKAA20.42940842
108PIK3CA0.42629562
109DYRK30.42508165
110PHKG20.42354097
111PHKG10.42354097
112BRSK10.42015953
113CSNK1E0.40815669
114FGFR30.40104534
115EGFR0.39831852
116ATM0.38551776
117CDK50.38490156
118RPS6KB10.38398660
119ERBB20.38142113
120PNCK0.37664136
121CAMK1D0.37556584
122CDK60.36783429
123ADRBK10.36760913
124PLK10.36741322
125RPS6KA40.36494648
126PRKAA10.36453715
127IGF1R0.35857162
128CDK120.35488534
129CAMK2B0.34415808
130KSR20.33650708
131PRPF4B0.33605269
132INSRR0.33105588
133STK240.32845692
134TTK0.32811772
135MUSK0.30647663
136MAPK120.30479918
137MAP3K70.30096025
138NTRK10.29809390
139PRKCZ0.28983964
140CAMK2D0.28441405
141CHEK20.28163526
142PAK60.28053721
143ZAK0.27446094
144CHUK0.26246576
145MARK20.24505710
146PDGFRB0.24375108
147RET0.24282782
148ADRBK20.24230232
149* MAPK100.24090762
150STK30.20638363

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.11158357
2Nicotine addiction_Homo sapiens_hsa050334.26748292
3Long-term potentiation_Homo sapiens_hsa047202.74596019
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48415512
5Amphetamine addiction_Homo sapiens_hsa050312.36636073
6Olfactory transduction_Homo sapiens_hsa047402.32433836
7Glutamatergic synapse_Homo sapiens_hsa047242.22556314
8Circadian entrainment_Homo sapiens_hsa047132.18293437
9Propanoate metabolism_Homo sapiens_hsa006401.96788034
10Steroid biosynthesis_Homo sapiens_hsa001001.89930905
11GABAergic synapse_Homo sapiens_hsa047271.89222730
12Taste transduction_Homo sapiens_hsa047421.86200905
13Morphine addiction_Homo sapiens_hsa050321.85600230
14Salivary secretion_Homo sapiens_hsa049701.85214549
15Renin secretion_Homo sapiens_hsa049241.81533483
16Long-term depression_Homo sapiens_hsa047301.80743899
17Serotonergic synapse_Homo sapiens_hsa047261.79682553
18Dopaminergic synapse_Homo sapiens_hsa047281.75289246
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75127393
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70976806
21GnRH signaling pathway_Homo sapiens_hsa049121.66693444
22Calcium signaling pathway_Homo sapiens_hsa040201.64107220
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60966014
24Gastric acid secretion_Homo sapiens_hsa049711.57452235
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56242131
26Hippo signaling pathway_Homo sapiens_hsa043901.55635145
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51885620
28Insulin secretion_Homo sapiens_hsa049111.45735769
29Tight junction_Homo sapiens_hsa045301.44471570
30Oxytocin signaling pathway_Homo sapiens_hsa049211.44372132
31Collecting duct acid secretion_Homo sapiens_hsa049661.41587093
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40225393
33Circadian rhythm_Homo sapiens_hsa047101.32933605
34Cholinergic synapse_Homo sapiens_hsa047251.29259585
35Synaptic vesicle cycle_Homo sapiens_hsa047211.25644374
36Basal transcription factors_Homo sapiens_hsa030221.24715250
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24339247
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23986812
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21999541
40cAMP signaling pathway_Homo sapiens_hsa040241.18848361
41Vitamin B6 metabolism_Homo sapiens_hsa007501.18813094
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17484038
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16772770
44Glioma_Homo sapiens_hsa052141.16683485
45Non-homologous end-joining_Homo sapiens_hsa034501.15150353
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14603806
47Hedgehog signaling pathway_Homo sapiens_hsa043401.13949671
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13537036
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12323221
50Dorso-ventral axis formation_Homo sapiens_hsa043201.08595891
51Melanogenesis_Homo sapiens_hsa049161.08039414
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06768097
53Fatty acid metabolism_Homo sapiens_hsa012121.06299107
54Histidine metabolism_Homo sapiens_hsa003401.04660186
55Protein export_Homo sapiens_hsa030601.01361594
56Selenocompound metabolism_Homo sapiens_hsa004501.00210092
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98566040
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97778285
59Starch and sucrose metabolism_Homo sapiens_hsa005000.97666343
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.97163207
61Basal cell carcinoma_Homo sapiens_hsa052170.97107941
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95008491
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94321914
64Axon guidance_Homo sapiens_hsa043600.91822602
65ErbB signaling pathway_Homo sapiens_hsa040120.91241234
66Type II diabetes mellitus_Homo sapiens_hsa049300.90865695
67Butanoate metabolism_Homo sapiens_hsa006500.89555505
68Cocaine addiction_Homo sapiens_hsa050300.89491655
69Nitrogen metabolism_Homo sapiens_hsa009100.88472762
70Glucagon signaling pathway_Homo sapiens_hsa049220.88418065
71Protein digestion and absorption_Homo sapiens_hsa049740.86407810
72Pancreatic secretion_Homo sapiens_hsa049720.85923852
73Choline metabolism in cancer_Homo sapiens_hsa052310.85857724
74Pyruvate metabolism_Homo sapiens_hsa006200.85251510
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.84793583
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84637438
77Fatty acid degradation_Homo sapiens_hsa000710.84563856
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84518003
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83144335
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82464292
81Gap junction_Homo sapiens_hsa045400.78576875
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78392297
83Retinol metabolism_Homo sapiens_hsa008300.78173995
84Oocyte meiosis_Homo sapiens_hsa041140.77534785
85Fatty acid elongation_Homo sapiens_hsa000620.77452060
86African trypanosomiasis_Homo sapiens_hsa051430.76461074
87Arginine and proline metabolism_Homo sapiens_hsa003300.75471102
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75174301
89Lysine degradation_Homo sapiens_hsa003100.75084714
90Staphylococcus aureus infection_Homo sapiens_hsa051500.73801002
91ECM-receptor interaction_Homo sapiens_hsa045120.73410414
92Wnt signaling pathway_Homo sapiens_hsa043100.72748448
93beta-Alanine metabolism_Homo sapiens_hsa004100.71684530
94MicroRNAs in cancer_Homo sapiens_hsa052060.71648727
95Fat digestion and absorption_Homo sapiens_hsa049750.71503883
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71345939
97Ovarian steroidogenesis_Homo sapiens_hsa049130.70650826
98Phototransduction_Homo sapiens_hsa047440.69904094
99Estrogen signaling pathway_Homo sapiens_hsa049150.69174909
100Proteoglycans in cancer_Homo sapiens_hsa052050.67288073
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.67269363
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65536478
103Mineral absorption_Homo sapiens_hsa049780.65402048
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63878380
105Rheumatoid arthritis_Homo sapiens_hsa053230.63622784
106Ras signaling pathway_Homo sapiens_hsa040140.63619477
107Cell cycle_Homo sapiens_hsa041100.63590858
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63565155
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61737831
110MAPK signaling pathway_Homo sapiens_hsa040100.61530524
111Vitamin digestion and absorption_Homo sapiens_hsa049770.60308834
112Thyroid cancer_Homo sapiens_hsa052160.60251971
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.59774512
114mTOR signaling pathway_Homo sapiens_hsa041500.58441062
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58413642
116PPAR signaling pathway_Homo sapiens_hsa033200.58375771
117FoxO signaling pathway_Homo sapiens_hsa040680.57449154
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56523669
119Alcoholism_Homo sapiens_hsa050340.55463498
120Thyroid hormone synthesis_Homo sapiens_hsa049180.55433056
121ABC transporters_Homo sapiens_hsa020100.55099877
122Focal adhesion_Homo sapiens_hsa045100.54653273
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54064448
124mRNA surveillance pathway_Homo sapiens_hsa030150.53954008
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53938012
126Arginine biosynthesis_Homo sapiens_hsa002200.53015760
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52487120
128Vibrio cholerae infection_Homo sapiens_hsa051100.52285232
129Peroxisome_Homo sapiens_hsa041460.51927016
130Sphingolipid metabolism_Homo sapiens_hsa006000.51818509
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49224317
132Pancreatic cancer_Homo sapiens_hsa052120.48925598
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48674412
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46467143
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44580127
136Ether lipid metabolism_Homo sapiens_hsa005650.42973038
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.40231062
138Rap1 signaling pathway_Homo sapiens_hsa040150.39527849
139Inositol phosphate metabolism_Homo sapiens_hsa005620.39237497
140Adherens junction_Homo sapiens_hsa045200.39159894
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38308852
142Fatty acid biosynthesis_Homo sapiens_hsa000610.37575061
143Prion diseases_Homo sapiens_hsa050200.36720867
144TGF-beta signaling pathway_Homo sapiens_hsa043500.36192235
145Dilated cardiomyopathy_Homo sapiens_hsa054140.35818792
146Chemical carcinogenesis_Homo sapiens_hsa052040.35652488
147Melanoma_Homo sapiens_hsa052180.34867277
148Bile secretion_Homo sapiens_hsa049760.33364267
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32470551
150Tuberculosis_Homo sapiens_hsa051520.31147451
151Endometrial cancer_Homo sapiens_hsa052130.29068914
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27903611
153Colorectal cancer_Homo sapiens_hsa052100.27530423
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27458233
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27276487
156Other glycan degradation_Homo sapiens_hsa005110.25810783
157Chemokine signaling pathway_Homo sapiens_hsa040620.25293536
158Complement and coagulation cascades_Homo sapiens_hsa046100.25107738
159Prolactin signaling pathway_Homo sapiens_hsa049170.24184804
160Phagosome_Homo sapiens_hsa041450.23357289

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